WO2019152415A3 - Magnesium based bioresorbable electrodes for recording, stimulation and drug delivery - Google Patents

Magnesium based bioresorbable electrodes for recording, stimulation and drug delivery Download PDF

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Publication number
WO2019152415A3
WO2019152415A3 PCT/US2019/015668 US2019015668W WO2019152415A3 WO 2019152415 A3 WO2019152415 A3 WO 2019152415A3 US 2019015668 W US2019015668 W US 2019015668W WO 2019152415 A3 WO2019152415 A3 WO 2019152415A3
Authority
WO
WIPO (PCT)
Prior art keywords
conductive polymer
recording
stimulation
electrode
electrodes
Prior art date
Application number
PCT/US2019/015668
Other languages
French (fr)
Other versions
WO2019152415A2 (en
Inventor
Huinan Liu
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Publication of WO2019152415A2 publication Critical patent/WO2019152415A2/en
Publication of WO2019152415A3 publication Critical patent/WO2019152415A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/263—Bioelectric electrodes therefor characterised by the electrode materials
    • A61B5/268—Bioelectric electrodes therefor characterised by the electrode materials containing conductive polymers, e.g. PEDOT:PSS polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A61B5/293—Invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/0436—Material of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36062—Spinal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36064—Epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36067—Movement disorders, e.g. tremor or Parkinson disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

A bioresorbable electrode including a magnesium microwire and a conductive polymer coating deposited on the Mg microwire; methods of manufacturing the electrode, methods of recording an electrical signal from a neuron with the electrode; methods of electrically stimulating a neuron with the electrode by applying an electrical stimulus to the neuron; and a method for delivering a drug, wherein the conductive polymer is loaded with the drug, and actuating the conductive polymer by applying an electrical stimulation to cause the conductive polymer to change a redox state of the polymer, wherein the drug is released from the conductive polymer.
PCT/US2019/015668 2018-01-31 2019-01-29 Magnesium based bioresorbable electrodes for recording, stimulation and drug delivery WO2019152415A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862624344P 2018-01-31 2018-01-31
US62/624,344 2018-01-31

Publications (2)

Publication Number Publication Date
WO2019152415A2 WO2019152415A2 (en) 2019-08-08
WO2019152415A3 true WO2019152415A3 (en) 2019-09-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/015668 WO2019152415A2 (en) 2018-01-31 2019-01-29 Magnesium based bioresorbable electrodes for recording, stimulation and drug delivery

Country Status (1)

Country Link
WO (1) WO2019152415A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110420447A (en) * 2019-08-28 2019-11-08 福州山路体育设施有限公司 Score contactor
US20210101016A1 (en) * 2019-10-08 2021-04-08 Northeastern University Magnetic Microwires for Energy-Transporting Biomedical Applications
CN112626583B (en) * 2020-12-10 2022-03-08 深圳先进技术研究院 Construction method of conductive matrix soft interface, microelectrode and application
CN113808780B (en) * 2021-08-06 2022-11-11 东华大学 Stretchable conductive elastomer with fold structure and preparation and application thereof
CN113796866B (en) * 2021-08-10 2023-06-20 中山大学 Electrode and preparation method and application thereof
US20230101016A1 (en) * 2021-09-27 2023-03-30 Medtronic, Inc. Intra-body electrode with a poly(3,4-ethylenedioxythiophene)-based coating
WO2024015444A1 (en) * 2022-07-12 2024-01-18 Case Western Reserve University Transient electrodes and associated systems and methods for neural modulation and recording

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090012446A1 (en) * 2007-07-03 2009-01-08 Xinyan Cui Devices, systems and methods for release of chemical agents
US20160294028A1 (en) * 2015-04-03 2016-10-06 Yan Ye Solid state battery cells and methods for making and using same
US9508491B2 (en) * 2010-10-01 2016-11-29 Heraeus Deutschland GmbH & Co. KG Method for improving electrical parameters in capacitors comprising PEDOT/PSS as a solid electrolyte through a polyalkylene glycol
US20170020402A1 (en) * 2015-05-04 2017-01-26 The Board Of Trustees Of The University Of Illinois Implantable and bioresorbable sensors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090012446A1 (en) * 2007-07-03 2009-01-08 Xinyan Cui Devices, systems and methods for release of chemical agents
US9508491B2 (en) * 2010-10-01 2016-11-29 Heraeus Deutschland GmbH & Co. KG Method for improving electrical parameters in capacitors comprising PEDOT/PSS as a solid electrolyte through a polyalkylene glycol
US20160294028A1 (en) * 2015-04-03 2016-10-06 Yan Ye Solid state battery cells and methods for making and using same
US20170020402A1 (en) * 2015-05-04 2017-01-26 The Board Of Trustees Of The University Of Illinois Implantable and bioresorbable sensors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FATTAHI, POURIA ET AL.: "A review of organic and inorganic biomaterials for neural interfaces", ADVANCED MATERIALS (DEERFIELD BEACH, FLA., vol. 26, no. 12, 2014, pages 1846 - 85, XP055551451, doi:10.1002/adma.201304496 *
HARRIS, ALEXANDER R ET AL.: "Conducting Polymer Coated Neural Recording Electrodes", JOURNAL OF NEURAL ENGINEERING, vol. 10, no. 1, 12 December 2012 (2012-12-12), XP020238278, doi:10.1088/1741-2560/10/1/016004 *
LORRAINE F. FRANCIS ET AL.: "Chapter 6 - Dispersion and Solution Processes", MATERIALS PROCESSING: A UNIFIED APPROACH TO PROCESSING OF METALS, CERAMICS AND POLYMERS *
MIN JI KIM ET AL.: "Biodegradable and Elastomeric Poly(glycerol sebacate) as a Coating Material for Nitinol Bare Stent", BIOMED RESEARCH INTERNATIONAL, vol. 2014 *

Also Published As

Publication number Publication date
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