WO2019122427A3 - Diagnosis of infection by detecting rna in an extracellular vesicle (ev) - Google Patents

Diagnosis of infection by detecting rna in an extracellular vesicle (ev) Download PDF

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Publication number
WO2019122427A3
WO2019122427A3 PCT/EP2018/086785 EP2018086785W WO2019122427A3 WO 2019122427 A3 WO2019122427 A3 WO 2019122427A3 EP 2018086785 W EP2018086785 W EP 2018086785W WO 2019122427 A3 WO2019122427 A3 WO 2019122427A3
Authority
WO
WIPO (PCT)
Prior art keywords
infection
diagnosis
extracellular vesicle
detecting rna
detecting
Prior art date
Application number
PCT/EP2018/086785
Other languages
French (fr)
Other versions
WO2019122427A2 (en
Inventor
Pierre-Yves MANTEL
Original Assignee
Universite De Fribourg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite De Fribourg filed Critical Universite De Fribourg
Publication of WO2019122427A2 publication Critical patent/WO2019122427A2/en
Publication of WO2019122427A3 publication Critical patent/WO2019122427A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56905—Protozoa
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to a method for identifying an infection agent and/or a method of a diagnosing the presence of an infectious agent, the method comprising the detecting of RNA originating from the infectious agent in the serum of an individual, detecting RNA contained in extracellular vesicles (EVs) released from cells of the individual, in particular from blood cells.
PCT/EP2018/086785 2017-12-21 2018-12-21 Diagnosis of infection by detecting rna in a sample WO2019122427A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17209859 2017-12-21
EP17209859.2 2017-12-21

Publications (2)

Publication Number Publication Date
WO2019122427A2 WO2019122427A2 (en) 2019-06-27
WO2019122427A3 true WO2019122427A3 (en) 2019-08-01

Family

ID=60954783

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2018/086785 WO2019122427A2 (en) 2017-12-21 2018-12-21 Diagnosis of infection by detecting rna in a sample

Country Status (1)

Country Link
WO (1) WO2019122427A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111944894B (en) * 2020-08-24 2023-01-17 中国医科大学附属盛京医院 Molecular marker for prenatal noninvasive diagnosis of cleft lip and palate, neural tube malformation and congenital heart disease and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170253916A1 (en) * 2016-03-04 2017-09-07 University Of Notre Dame Du Lac Exosomal biomarkers diagnostic of tuberculosis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150010903A1 (en) 2012-03-16 2015-01-08 Davos Diagnostics Ag Real Time Diagnostic Assays Using an Evanescence Biosensor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170253916A1 (en) * 2016-03-04 2017-09-07 University Of Notre Dame Du Lac Exosomal biomarkers diagnostic of tuberculosis

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CAMPOS FERNANDA MF ET AL: "Augmented plasma microparticles during acute Plasmodium vivax infection", MALARIA JOURNAL, BIOMED CENTRAL, LONDON, GB, vol. 9, no. 1, 16 November 2010 (2010-11-16), pages 327, XP021088241, ISSN: 1475-2875, DOI: 10.1186/1475-2875-9-327 *
DUANGDAO NANTAKOMOL ET AL: "Circulating Red Cell-derived Microparticles in Human Malaria", JOURNAL OF INFECTIOUS DISEASES. JID, vol. 203, no. 5, 1 March 2011 (2011-03-01), US, pages 700 - 706, XP055580403, ISSN: 0022-1899, DOI: 10.1093/infdis/jiq104 *
JOHAN ANKARKLEV ET AL: "Uncovering the Role of Erythrocyte-Derived Extracellular Vesicles in Malaria: From Immune Regulation to Cell Communication", JOURNAL OF CIRCULATING BIOMARKERS, vol. 3, 1 January 2014 (2014-01-01), pages 3, XP055580490, ISSN: 1849-4544, DOI: 10.5772/58596 *
KEHINDE ADEBAYO BABATUNDE ET AL: "Malaria infected red blood cells release small regulatory RNAs through extracellular vesicles", SCIENTIFIC REPORTS, vol. 8, no. 1, 17 January 2018 (2018-01-17), XP055580507, DOI: 10.1038/s41598-018-19149-9 *
MANTEL PIERRE-YVES ET AL: "Malaria-Infected Erythrocyte-Derived Microvesicles Mediate Cellular Communication within the Parasite Population and with the Host Immune System", CELL HOST & MICROBE, ELSEVIER, NL, vol. 13, no. 5, 15 May 2013 (2013-05-15), pages 521 - 534, XP028564660, ISSN: 1931-3128, DOI: 10.1016/J.CHOM.2013.04.009 *
ULRIKE LAMBERTZ ET AL: "Small RNAs derived from tRNAs and rRNAs are highly enriched in exosomes from both old and new world Leishmania providing evidence for conserved exosomal RNA Packaging", BMC GENOMICS, BIOMED CENTRAL, vol. 16, no. 1, 5 March 2015 (2015-03-05), pages 151, XP021213625, ISSN: 1471-2164, DOI: 10.1186/S12864-015-1260-7 *

Also Published As

Publication number Publication date
WO2019122427A2 (en) 2019-06-27

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