WO2019088772A3 - 허혈성 심혈관 질환의 치료용 또는 예방용 약학 조성물 - Google Patents

허혈성 심혈관 질환의 치료용 또는 예방용 약학 조성물 Download PDF

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Publication number
WO2019088772A3
WO2019088772A3 PCT/KR2018/013278 KR2018013278W WO2019088772A3 WO 2019088772 A3 WO2019088772 A3 WO 2019088772A3 KR 2018013278 W KR2018013278 W KR 2018013278W WO 2019088772 A3 WO2019088772 A3 WO 2019088772A3
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WIPO (PCT)
Prior art keywords
prevention
treatment
pharmaceutical composition
cardiovascular disease
ischemic cardiovascular
Prior art date
Application number
PCT/KR2018/013278
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English (en)
French (fr)
Other versions
WO2019088772A2 (ko
Inventor
윤영섭
이기범
조현열
츄엥사이통
Original Assignee
연세대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020180111077A external-priority patent/KR102101384B1/ko
Application filed by 연세대학교 산학협력단 filed Critical 연세대학교 산학협력단
Priority to US16/769,196 priority Critical patent/US20210369653A1/en
Publication of WO2019088772A2 publication Critical patent/WO2019088772A2/ko
Publication of WO2019088772A3 publication Critical patent/WO2019088772A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 명세서에서는 ETV2 유전자에 대한 DNA 결합 도메인 (DNA binding domain) 을 포함하는 폴리아마이드, 핵 위치신호 (nuclear localization signal) 펩타이드 및 나노 입자를 포함하는, ETV2 전사 인자가 제공된다.
PCT/KR2018/013278 2017-11-02 2018-11-02 허혈성 심혈관 질환의 치료용 또는 예방용 약학 조성물 WO2019088772A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US16/769,196 US20210369653A1 (en) 2017-11-02 2018-11-02 Pharmaceutical composition for treatment or prevention of ischemic cardiovascular disease

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2017-0145305 2017-11-02
KR20170145305 2017-11-02
KR1020180111077A KR102101384B1 (ko) 2017-11-02 2018-09-17 허혈성 심혈관 질환의 치료용 또는 예방용 약학 조성물
KR10-2018-0111077 2018-09-17

Publications (2)

Publication Number Publication Date
WO2019088772A2 WO2019088772A2 (ko) 2019-05-09
WO2019088772A3 true WO2019088772A3 (ko) 2019-07-04

Family

ID=66332916

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/013278 WO2019088772A2 (ko) 2017-11-02 2018-11-02 허혈성 심혈관 질환의 치료용 또는 예방용 약학 조성물

Country Status (1)

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WO (1) WO2019088772A2 (ko)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100316702A1 (en) * 2008-01-08 2010-12-16 The Regents Of The University Of California Compositions and methods for regulating erythropoeitin expression and ameliorating anemia and stimulating erythropoiesis
KR20150104049A (ko) * 2014-03-03 2015-09-14 국립대학법인 울산과학기술대학교 산학협력단 체세포로부터 혈관 전구 세포로의 직접교차분화 유도용 조성물 및 이의 용도
JP5897002B2 (ja) * 2010-07-07 2016-04-13 セルラー ダイナミクス インターナショナル， インコーポレイテッド プログラミングによる内皮細胞の産生

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100316702A1 (en) * 2008-01-08 2010-12-16 The Regents Of The University Of California Compositions and methods for regulating erythropoeitin expression and ameliorating anemia and stimulating erythropoiesis
JP5897002B2 (ja) * 2010-07-07 2016-04-13 セルラー ダイナミクス インターナショナル， インコーポレイテッド プログラミングによる内皮細胞の産生
KR20150104049A (ko) * 2014-03-03 2015-09-14 국립대학법인 울산과학기술대학교 산학협력단 체세포로부터 혈관 전구 세포로의 직접교차분화 유도용 조성물 및 이의 용도

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PANDIAN, G. N.: "A synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts", SCIENTIFIC REPORTS, 2012, XP055484116 *
PATEL, S.: "Nanoscript: A nanoparticle-based artificial transcription factor for effective gene regulation", ASC NANO, vol. 8, no. 9, 2014, pages 8959 - 8967, XP055337302, doi:10.1021/nn501589f *

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