WO2019088547A3 - Use of ellipticine for inducing differentiation of stem cell into chondrocyte - Google Patents

Use of ellipticine for inducing differentiation of stem cell into chondrocyte Download PDF

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Publication number
WO2019088547A3
WO2019088547A3 PCT/KR2018/012558 KR2018012558W WO2019088547A3 WO 2019088547 A3 WO2019088547 A3 WO 2019088547A3 KR 2018012558 W KR2018012558 W KR 2018012558W WO 2019088547 A3 WO2019088547 A3 WO 2019088547A3
Authority
WO
WIPO (PCT)
Prior art keywords
ellipticine
chondrocyte
stem cell
inducing differentiation
differentiation
Prior art date
Application number
PCT/KR2018/012558
Other languages
French (fr)
Korean (ko)
Other versions
WO2019088547A2 (en
Inventor
황기철
임소연
최정원
이지윤
Original Assignee
가톨릭관동대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 가톨릭관동대학교산학협력단 filed Critical 가톨릭관동대학교산학협력단
Publication of WO2019088547A2 publication Critical patent/WO2019088547A2/en
Publication of WO2019088547A3 publication Critical patent/WO2019088547A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a use of ellipticine for inducing the differentiation of a stem cell into a chondrocyte. More specifically, by proving that ellipticine has excellent capability for inducing the differentiation of a stem cell into a chondrocyte, and the chondrocyte obtained by the ellipticine-induced differentiation has an excellent therapeutic effect for osteoarthritis or the like, the present invention can provide a potential use as a cell therapy product for chondropathy.
PCT/KR2018/012558 2017-10-31 2018-10-23 Use of ellipticine for inducing differentiation of stem cell into chondrocyte WO2019088547A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170143627A KR101998633B1 (en) 2017-10-31 2017-10-31 Use of ellipticine for inducing differentiation of stem cells into chondrocytes
KR10-2017-0143627 2017-10-31

Publications (2)

Publication Number Publication Date
WO2019088547A2 WO2019088547A2 (en) 2019-05-09
WO2019088547A3 true WO2019088547A3 (en) 2019-06-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/012558 WO2019088547A2 (en) 2017-10-31 2018-10-23 Use of ellipticine for inducing differentiation of stem cell into chondrocyte

Country Status (2)

Country Link
KR (1) KR101998633B1 (en)
WO (1) WO2019088547A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100124335A (en) * 2008-03-17 2010-11-26 더 스크립스 리서치 인스티튜트 Combined chemical and genetic approaches for generation of induced pluripotent stem cells
KR20130019459A (en) * 2011-08-16 2013-02-27 의료법인 성광의료재단 Process for expanding amniotic fluid-derived mesenchymal stem cells and process for preparing grafting constructs comprising the same
WO2014097192A2 (en) * 2012-12-18 2014-06-26 Cnc - Centro De Neurociências E Biologia Molecular - Universidade De Coimbra Differentiated cell population of endothelial cells derived from human pluripotent stem cells, composition, system, kit and uses thereof
KR20160104612A (en) * 2013-07-26 2016-09-05 업데이트 파마 인코포레이트 Compositions to improve the therapeutic benefit of bisantrene

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100124335A (en) * 2008-03-17 2010-11-26 더 스크립스 리서치 인스티튜트 Combined chemical and genetic approaches for generation of induced pluripotent stem cells
KR20130019459A (en) * 2011-08-16 2013-02-27 의료법인 성광의료재단 Process for expanding amniotic fluid-derived mesenchymal stem cells and process for preparing grafting constructs comprising the same
WO2014097192A2 (en) * 2012-12-18 2014-06-26 Cnc - Centro De Neurociências E Biologia Molecular - Universidade De Coimbra Differentiated cell population of endothelial cells derived from human pluripotent stem cells, composition, system, kit and uses thereof
KR20160104612A (en) * 2013-07-26 2016-09-05 업데이트 파마 인코포레이트 Compositions to improve the therapeutic benefit of bisantrene

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LIU, J.: "Polymer-drug compatibility: A Guide to the development of delivery systems for the anticancer agent, ellipticine", JOURNAL OF PHARMACEUTICAL SCIENCES, 2004, pages 132 - 143, XP055018856, DOI: doi:10.1002/jps.10533 *

Also Published As

Publication number Publication date
KR101998633B1 (en) 2019-07-11
WO2019088547A2 (en) 2019-05-09
KR20190048560A (en) 2019-05-09

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