WO2019087158A3 - Formulation comprising oxazolidin-2-one-pyrimidine derivative - Google Patents

Formulation comprising oxazolidin-2-one-pyrimidine derivative Download PDF

Info

Publication number
WO2019087158A3
WO2019087158A3 PCT/IB2018/058677 IB2018058677W WO2019087158A3 WO 2019087158 A3 WO2019087158 A3 WO 2019087158A3 IB 2018058677 W IB2018058677 W IB 2018058677W WO 2019087158 A3 WO2019087158 A3 WO 2019087158A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxazolidin
formulation
pyrimidine derivative
compositions
formula
Prior art date
Application number
PCT/IB2018/058677
Other languages
French (fr)
Other versions
WO2019087158A2 (en
Inventor
Eric Aubin
Paolo DE MARCO
Rajesh A. KUMAR
Andreas Lerchner
Isabelle Rault
Bernd Ulrich Riebesehl
Frank Hans Seiler
Karin SVEDBERG
Henricus Lambertus Gerardus Maria Tiemessen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of WO2019087158A2 publication Critical patent/WO2019087158A2/en
Publication of WO2019087158A3 publication Critical patent/WO2019087158A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel topical pharmaceutical compositions comprising an oxazolidin-2-one-pyrimidine compound of formula (I), a method of manufacturing such compositions, as well as uses of such compositions. The present invention also relates to a novel crystalline form of the compound of formula (I).
PCT/IB2018/058677 2017-11-06 2018-11-05 Formulation comprising oxazolidin-2-one-pyrimidine derivative WO2019087158A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201711039501 2017-11-06
IN201711039501 2017-11-06

Publications (2)

Publication Number Publication Date
WO2019087158A2 WO2019087158A2 (en) 2019-05-09
WO2019087158A3 true WO2019087158A3 (en) 2019-06-20

Family

ID=64316605

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2018/058677 WO2019087158A2 (en) 2017-11-06 2018-11-05 Formulation comprising oxazolidin-2-one-pyrimidine derivative

Country Status (2)

Country Link
TW (1) TW201929861A (en)
WO (1) WO2019087158A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014072956A1 (en) * 2012-11-12 2014-05-15 Novartis Ag Oxazolidin-2-one-pyrimidine derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014072956A1 (en) * 2012-11-12 2014-05-15 Novartis Ag Oxazolidin-2-one-pyrimidine derivatives

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"butylparaben, methylparaben, propylparaben ED - Rowe Raymond C", 31 December 2006, HANDBOOK OF PHARMACEUTICAL EXCIPIENTS, PHARMACEUTICAL PRESS, LONDON, PAGE(S) 83 - 85,466, ISBN: 0-85369-618-7, XP002706362 *
"Handbook of Pharmaceutical Excipients, 3rd edition", 2000, AMERICAN PHARMACEUTICAL ASSOCIATION, Washington, D.C., article P J WELLER: "Phenoxyethanol", pages: 370 - 371, XP055546212 *
"Handbook of Pharmaceutical Excipients, 3rd edition", 2000, AMERICAN PHARMACEUTICAL ASSOCIATION, Washington, D.C., article P J WELLER: "Phenylethyl Alcohol", pages: 372 - 373, XP055546213 *
KIBBE A H: "BENZYL ALCOHOL", 2000, HANDBOOK OF PHARMACEUTICAL EXCIPIENTS, ED.3, AMERICAN PHARMACEUTICAL ASSOCIATION ET AL, USA, PAGE(S) 41,191 - 220,,372,442, XP002533446 *

Also Published As

Publication number Publication date
WO2019087158A2 (en) 2019-05-09
TW201929861A (en) 2019-08-01

Similar Documents

Publication Publication Date Title
PH12018501099A1 (en) Novel biphenyl compound or salt thereof
TN2018000395A1 (en) New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
EP4248968A3 (en) Tlr7/8 antagonists and uses thereof
MX2018002986A (en) Heteroaryl compounds as irak inhibitors and uses thereof.
NZ739676A (en) Heteroaryl compounds as irak inhibitors and uses thereof
PH12015500491A1 (en) C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof
WO2012125488A8 (en) C4-monomethyl triterpenoid derivatives and methods of use thereof
NZ716840A (en) Combination formulation of two antiviral compounds
MX2017014035A (en) Solid forms.
AU2020317609A8 (en) Novel heteroaryl-triazole compounds as pesticides
PH12015502802A1 (en) Formulation comprising a hypolipidemic agent
MX2020009234A (en) Heteroaryl compounds as type ii irak inhibitors and uses hereof.
PH12018501644A1 (en) Tlr7 agonist maleate salt, crystalline forms c, d and e thereof, preparation methods and uses of maleate salt and crystalline forms
CA2891755C (en) Substituted pyrido-piperazinone derivatives as gamma secretase modulators
PH12014502752A1 (en) Novel cyclic depsipeptide derivative and pest control agent compromising same
EP4327880A3 (en) Solid state form of ribociclib succinate
MX2019013979A (en) Methods for the preparation of 1,3-benzodioxole heterocyclic compounds.
WO2017064627A3 (en) Process for preparation of eribulin and intermediates thereof
PH12017502319A1 (en) Injectable pharmaceutical formulations of lefamulin
MX2021001904A (en) Solid forms of substituted benzoxaborole and compositions thereof.
PH12017501404A1 (en) Diaza-benzofluoranthrene compounds
MX2017008074A (en) IMIDAZOPYRIDAZINE DERIVATIVES AS PI3Kß INHIBITORS.
EP4282973A3 (en) Processes for the preparation of pyrimidinylcyclopentane compounds
WO2020139971A3 (en) Methods for making dimeric naphthalimides and solid state forms of the same
MX2017008076A (en) Heterocyclyl linked imidazopyridazine derivatives as pi3kbeta inhibitors.

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18803787

Country of ref document: EP

Kind code of ref document: A2