WO2019078676A2 - Procédé et dispositif de transfert d'une monocouche de nanoparticules au moyen d'un tube capillaire - Google Patents

Procédé et dispositif de transfert d'une monocouche de nanoparticules au moyen d'un tube capillaire Download PDF

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WO2019078676A2
WO2019078676A2 PCT/KR2018/012422 KR2018012422W WO2019078676A2 WO 2019078676 A2 WO2019078676 A2 WO 2019078676A2 KR 2018012422 W KR2018012422 W KR 2018012422W WO 2019078676 A2 WO2019078676 A2 WO 2019078676A2
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nanoparticles
capillary
substrate
single layer
monolayer
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PCT/KR2018/012422
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Korean (ko)
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WO2019078676A3 (fr
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강태욱
장지한
이재경
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서강대학교산학협력단
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Priority claimed from KR1020180116757A external-priority patent/KR102086740B1/ko
Application filed by 서강대학교산학협력단 filed Critical 서강대학교산학협력단
Priority to US16/757,369 priority Critical patent/US11499893B2/en
Publication of WO2019078676A2 publication Critical patent/WO2019078676A2/fr
Publication of WO2019078676A3 publication Critical patent/WO2019078676A3/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units

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  • the present disclosure relates to a method and apparatus for nanoparticle monolayer transfer using a capillary.
  • a single-layer structure of nanoparticles utilizing self-assembly at the interface between water and organic solvent can be applied to various fields such as high-efficiency electrodes, molecular detection, and energy harvesting due to their unique mechanical, optical, Has attracted attention as a next-generation material capable of solving the problems of existing technologies.
  • a single layer of nanoparticles present at the interface is generally transferred to a solid substrate and applied to real life applications.
  • the most widely used method for transferring a single layer of interfacial nanoparticles to a solid substrate is Langmuir film deposition [Lu, Y., Liu, GL & Lee, LP High-density silver nanoparticle film with temperature- controllable interparticle spacing for a tunable surface enhanced Raman scattering substrate. Nano Lett. 5, 5-9 (2005)].
  • the Langmuir-film deposition method is simply performed by bringing the substrate into contact with a single layer of nanoparticles at the interface.
  • LB Langmuir-Blodgett
  • LS Langmuir-Schaefer
  • the Langmuir film deposition method has a merit that it is possible to fabricate a large-sized substrate with a relatively simple process and to control the density of the nanoparticles. However, since the substrate and the interface must be in uniform contact, there was.
  • the existing Langmuir film deposition method was limited to glass substrates and silicon flat substrates, and it was difficult to apply them to solid surfaces having various structures and surface properties.
  • the Langmuir film deposition method has a disadvantage in that it is difficult to precisely control the transition area and shape of the single layer of nanoparticles as well as the position to be transferred.
  • ⁇ CP microcontact printing
  • the ⁇ CP technique solves some of the disadvantages of Langmuir film deposition, such as substrate dependence and low operability.
  • the polymer stamp used as a medium deformed by shrinkage and swelling during the transfer process,
  • nanoparticle loss occurs when the attractive force with the polymer stamp is larger.
  • the nanoparticle structure deposited on a solid substrate using the above-described technique can be applied to various fields such as electronic devices, catalysts, and energy harvesting as mentioned above. Especially, it is expected to be very promising in the field of optical molecule detection such as microfluidic system, inspection of food surface stability, inspection of illegal drugs such as drugs, and discrimination of counterfeit bills.
  • nanoparticles were introduced into microfluidic channels, food, and banknote surfaces to attempt optical molecular detection [Osberg, KD, Rycenga, M., Bourret, GR, Brown, KA, & Mirkin, Raman Scattering Nanosheets. Adv. Mater. 24, 6065-6070 (2012); Li, J. F. et al. Shell-isolated nanoparticle-enhanced Raman spectroscopy. Nature 464, 392 (2010)], presently this technique remains at the level of evaporating the solvent of the nanoparticle solution from the solid surface or immersing the solid into the nanoparticle solution for a period of time.
  • the reproducibility of the deposition depends on the random attachment of the nanoparticles, and the sensitivity of the detection is also low because the nanoparticle structure can not be formed at a high density.
  • Exemplary embodiments of the present invention in one aspect, provide a capillary nanoparticle single layer transfer method and apparatus capable of transferring uniform nanoparticle monolayers to a high reproducibility regardless of substrate structure and surface energy. .
  • a nanoparticle single layer transfer method and apparatus using a capillary capable of controlling the area of a single layer of nanoparticles to be transferred and the kind of nanoparticles.
  • a capillary-based nanoparticle capable of fabricating a microfluidic device coupled with an optical molecular detection system by introducing a single layer of nanoparticles into a small- To provide a single layer transfer method and apparatus.
  • Exemplary embodiments of the present invention provide a nanoparticle single layer transfer method using a capillary wherein a monolayer of nanoparticles is separated using a capillary and transferred to a substrate.
  • the method comprises: forming a single layer nanoparticle monolayer at the interface between the liquid gases; Contacting the capillary to an interface between the liquid gas to separate the monolayer of nanoparticles into a capillary; And transferring a single layer of nanoparticles in the capillary to the substrate.
  • a capillary nanoparticle single layer transfer device comprising a capillary that separates a single layer of nanoparticles and then transitions, as a nanoparticle single layer transfer device.
  • the apparatus is a nanoparticle single layer transfer device, comprising: a nanoparticle monolayer forming portion in which a monolayer of nanoparticles is formed at an interface between liquid gasses; And a capillary provided to the single layer forming unit.
  • a method of detecting a substance to be detected comprising: separating a single layer of nanoparticles using a capillary and transferring the substance to a substrate on which a substance to be detected is located; And detecting a substance to be detected on the substrate from the Raman signal of the single layer of the transferred nanoparticles.
  • an apparatus for detecting a substance to be detected includes: a capillary that separates a single layer of nanoparticles and then transitions; And a detector for irradiating a laser beam onto the single layer of the transferred nanoparticles and detecting a detection target material from the Raman signal of the nanoparticle single layer.
  • the detection method and apparatus may be to detect drugs or explosives on the garment surface or bill face, or to detect harmful substances on the food surface.
  • a method for discriminating whether or not a banknote is counterfeited includes separating a monolayer of nanoparticles using a capillary and transferring a monolayer of nanoparticles in the capillary to at least one banknote And discriminating whether the banknote is a genuine paper when the Raman signal of the single layer of the transferred nanoparticles is measured.
  • a method of manufacturing a microfluidic channel comprising the steps of separating a single layer of nanoparticles using a capillary and transitioning to a microfluidic channel.
  • the capillary having a small diameter since the capillary having a small diameter is used, it is less influenced by the curvature of the substrate. Therefore, the present invention can be applied to a solid substrate having various structures other than a flat surface.
  • the capillary can be easily manipulated as compared with Langmuir film deposition method, and thus it is possible to transfer to a desired position with high accuracy.
  • a single layer of nanoparticles when used as a probe of an optical sensor, since the diameter of the general laser irradiation area is on the order of micrometer, the efficiency of the number of nanoparticles relative to the laser irradiation area is low in the conventional large area transfer method, According to embodiments, a single layer of nanoparticles can be transferred with an area of, for example, less than 1 mm in diameter, which is close to the laser irradiation area. Therefore, the efficiency of the number of nanoparticles relative to the laser irradiation area can be greatly improved.
  • capillary nanoparticle single layer transfer method and apparatus of the exemplary embodiments of the present invention require only one commercially available glass capillary tube, so that it is not required to have special expertise of the special equipment or the tester, .
  • capillary nanoparticle single layer transfer method and apparatus of the exemplary embodiments of the present invention simultaneous multiple transfer of a single layer of nanoparticles through a plurality of capillary bundles is possible and complex patterning is also possible.
  • Figure 1 is a schematic diagram illustrating the concept of a nanoparticle monolayer transfer technique using capillaries in an exemplary embodiment of the invention.
  • FIG. 2 is a photograph of a single layer of a gold nanoparticle having a size of 50 nm located at a liquid-gas interface and a single layer of the single layer being transferred to a PDMS substrate having a length of 1 cm on one side using the conventional method in the comparative example of the present invention .
  • FIGS. 3A through 3D illustrate photographs in which a monolayer of a gold nanoparticle having a size of 50 nm is transferred to PDMS substrates at various sizes using a capillary transfer technique in an embodiment of the present invention.
  • FIG. 3A through 3D illustrate photographs in which a monolayer of a gold nanoparticle having a size of 50 nm is transferred to PDMS substrates at various sizes using a capillary transfer technique in an embodiment of the present invention.
  • FIGS. 4A and 4B are cross-sectional views of a photomicrograph (FIG. 4A) of a spherical gold nanoparticle single layer 50 nm in size using a plurality of capillary bundles (FIG. 4A) (Fig. 4B).
  • Figures 5A-5F are UV data for six different types of nanoparticles in an embodiment of the invention.
  • FIGS. 6A to 6F show results obtained by observing a single layer of various nanoparticles transferred onto a glass substrate using a capillary-based transferring technique with a scanning electron microscope in the embodiment of the present invention.
  • Spherical gold nanoparticles each having a size of 50 nm (FIG. 6A), spherical gold nanoparticles having a size of 17 nm (FIG. 6B), spherical gold nanoparticles having a size of 50 nm, and core- (FIG. 6C), gold nanorods (FIG. 6D), spherical silver nanoparticles of 45 nm in size (FIG. 6E) and spherical silver nanoparticles of 30 nm in size (FIG.
  • FIGS. 7A to 7D show photographs in which a single layer of gold nanoparticles having a size of 50 nm is transferred to a size of 1 mm in diameter on the surfaces (front and back sides) of two kinds of leaves having a smooth living body surface in the embodiment of the present invention.
  • Figure 8 shows that, in an embodiment of the present invention, Escherichia coli ) shows a scanning electron microscopic result of a single layer of gold nanoparticles having a size of 50 nm on the surface of a PDMS in which there is a high density.
  • 9A to 9G show that in the embodiment of the present invention, after forming various PDMS microfluidic channels having a width of 1 mm and a depth of 650 mu m, a monolayer of spherical gold nanoparticles having a size of 50 nm is transferred Represents one photograph.
  • FIG. 10 is a graph showing the results of detection of 1 mM rhodamine 6G in a microfluidic channel in which gold nanorod monolayers are transferred through a surface enhanced Raman scattering method in the embodiment of the present invention.
  • Figure 11 shows a photograph of a single layer of spherical gold nanoparticles of 50 nm in size transitioned to a diameter of 1 mm using a capillary in a fibrous fabric of the garment surface in an embodiment of the invention.
  • Fig. 12 shows the results of detection of benzocaine using a surface enhanced Raman scattering method in a monolayer of spherical gold nanoparticles transferred to the surface of a garment containing benzocain, which is a similar drug of cocaine, in the embodiment of the present invention.
  • FIG. 13 shows a photograph of a spherical gold nanoparticle single layer having a size of 50 nm transferred to a diameter of 1 mm by using a capillary on the surface of rice grains in an embodiment of the present invention.
  • FIG. 14 is a graph showing the results of detection of chlorpyrifos-methyl as a pesticide component by surface enhanced Raman scattering in a single layer of spherical gold nanoparticles transferred onto the surface of a rice grain containing commercially available agricultural chemicals Results are shown.
  • FIG. 15 shows a photograph of a spherical gold nanoparticle monolayer having a size of 50 nm transferred to a diameter of 1 mm using a capillary on the surface of an orange shell in an embodiment of the present invention.
  • FIG. 16 is a graph showing the results of detection of chlorpyrifos-methyl as a pesticide component using a surface enhanced Raman scattering method in a single layer of spherical gold nanoparticles transferred onto the surface of an orange skin containing commercial pesticide components .
  • Figure 17 shows various points of a US $ 100 bill to insert a chemical code for counterfeit bill protection in an embodiment of the present invention.
  • Figures 18A-18J are Raman signal results showing that strong peaks near 250 cm < -1 > are common in all gold nanoparticle monolayer locations transferred to a $ 100 bill in an embodiment of the present invention.
  • nano means 1000 nm or less.
  • the term " two-dimensional " means that there is no difference of more than one order between the horizontal size and the vertical size of the structure, but has a difference of at least one order of magnitude between the horizontal size and the thickness or the vertical size and thickness .
  • the plate shape is a two-dimensional shape.
  • harmful substances are organophosphorus insecticides such as chlorpyrifos, chlorpyrifos-methyl, parathion, methyl parathion, carbophenothion and penitrothion, organic chlorine based, mercury based, carbamate based insecticides And other pesticides and other substances known to be harmful to human body.
  • organophosphorus insecticides such as chlorpyrifos, chlorpyrifos-methyl, parathion, methyl parathion, carbophenothion and penitrothion, organic chlorine based, mercury based, carbamate based insecticides And other pesticides and other substances known to be harmful to human body.
  • drugs include illegal drugs such as phylloxes, cocaine, cannabis, and other drugs, etc., which are restricted or prohibited by law.
  • the present inventors Using the capillary phenomenon of surface elevation in a thin tube due to surface tension, the present inventors have found that a single layer of a single layer of nanoparticles existing at a liquid and gas interface, more specifically, for example, an aqueous solution and an air interface, And a single layer of single-layer nanoparticles separated by inverting the capillary is transferred to the substrate.
  • a nanoparticle monolayer transfer method there is provided a monolayer nanoparticle transfer method using a capillary, wherein a monolayer of nanoparticles is separated using a capillary and transferred to a substrate.
  • the method comprises forming a monolayer nanoparticle monolayer at the interfacial surface of the liquid gas, contacting the capillary at the liquid gas interfacial surface to receive the nanoparticle monolayer locally and selectively into the capillary, And inverting the capillary and contacting the substrate with the capillary to transfer the monolayer of nanoparticles in the capillary to the substrate.
  • a nanoparticle single layer transfer device comprising: a nanoparticle single layer transfer device using a capillary, comprising a capillary for separating a monolayer of nanoparticles and then transferring a single layer of the nanoparticle; Lt; / RTI >
  • the apparatus is a nanoparticle single layer transfer apparatus comprising: a nanoparticle single layer forming unit in which a single layer of nanoparticles is formed at an interface between liquid gasses; And a capillary-based nanoparticle single layer transfer device including the capillary provided in the single-layer forming portion.
  • FIG. 1 is a schematic diagram illustrating the transition of a single layer of nanoparticles, which is self-assembled at the air interface with the nanoparticle aqueous solution, using a capillary to an exemplary solid substrate in an exemplary embodiment of the present invention.
  • nanoparticles dispersed in water can self-assemble into a monolayer at the interface between water and air by controlling inter-particle interaction using an organic solvent.
  • the liquid-gas interface is formed by first forming a liquid-liquid interface and then evaporating the liquid at the top to form an interface, or directly forming a liquid- Can be formed.
  • a single layer of nanoparticles present at the liquid-liquid interface it is usually possible to evaporate the liquid phase present in the upper layer and then transfer a single layer present at the liquid-air interface.
  • a single layer of nanoparticles is first formed on the water-nucleic acid interface, the nucleic acid is evaporated, and transferred to the substrate.
  • the organic solvent used in the liquid phase to form the interface with water may be an organic solvent such as benzene, toluene, chloroform, nucleic acid, fatty acid series such as oleic acid, .
  • alcohol may be added in a liquid-liquid phase.
  • an organic solvent such as benzene, toluene, nucleic acid or chloroform may be used as the lower liquid phase.
  • the gaseous phase can be air.
  • the capillary is brought into contact with the interface where the nanoparticle monolayer is present, and a single layer of the nanoparticle is accommodated in the capillary together with the liquid by capillary action.
  • a capillary tube having a cross-sectional diameter of 2 mm or less for example 0.1 to 2 mm, or 0.1 to 1.5 mm, or 0.1 to 1 mm, can be vertically contacted at the water-air interface at which the nanoparticle monolayer is present .
  • the capillary force due to the surface tension of the water causes a sudden rise in the water surface inside the capillary.
  • the single layer of nanoparticles inside the capillary keeps its structure at the interface and rises with the water.
  • the capillary tube is turned upside down so that the capillary tube is in contact with the surface of the water.
  • gravity causes the solution in the capillary tube to come down in the opposite direction and expose the nanoparticle single layer structure to the capillary tube.
  • the single layer of nanoparticles transferred by the capillary transfer method becomes relatively more uniform.
  • the single layer of nanoparticles existing at the interface is irregularly present such as where the nanoparticles are present and absent from the naked eye.
  • the single layer of nanoparticles separated and transferred by the capillaries may range in diameter from about 0.1 to 2 mm, area from about 0.01 to 4 mm 2 .
  • the size of the nanoparticles to be transferred may be between 5 and 200 nm in diameter.
  • the nanoparticles to be transferred are not particularly limited, but may be one or more selected from inorganic materials such as metals, metal oxides, and organic materials.
  • the metal may be Au, Ag, Pd, Pt, Al, Cu, Co, Cr, Mn, Ni
  • the inorganic material may be silica, quantum dot, lanthanide, iron oxide, and the like.
  • the organic material may be polystyrene, polyethylene glycol, or the like.
  • the shape of the nanoparticles to be transferred is not particularly limited, and may be one or more selected from the group consisting of, for example, spheres, rods, ellipsoids, dendrimers, tetrahedrons, hexahedrons, octahedrons,
  • the nanoparticles may also be in the form of a core-shell.
  • the substrate to be transferred is not limited as long as it can receive a single layer of nanoparticles from the capillary, for example, a hydrophilic or hydrophobic substrate, more specifically a hydrophilic or hydrophobic solid substrate.
  • the substrate can be one or more substrates selected from polymers, glass, ITO, silicon, metal, paper, cells,
  • the polymer-based substrate may be one or more selected from PDMS, PMMA, hydrogel, and the like.
  • the metal may be at least one selected from Au, Ag, Pd, Pt, Al, Cu, Co, Cr, Mn, Ni and Fe.
  • the substrate to be transferred may be a flat substrate, a substrate having a large surface roughness, a curved substrate having a large curvature, and the like, which may include a fibrous substrate, a porous substrate, and the like.
  • the substrate may be at least one selected from the group consisting of rice, vegetable, fruit, meat, seafood, paper of various foods, clothes, banknotes, porous filters, cells of living organisms, microorganisms,
  • the living body may be a skin layer cell of, for example, animal or plant.
  • the microorganism may be, for example, E. coli coated on a substrate.
  • the substrate to be transferred may be a microfluidic channel.
  • the method and apparatus of the present invention allows for the simultaneous transfer of multiple single-layer nanoparticles of small area to the same substrate using a plurality of capillaries, and the complex shape of the patterning is also possible by controlling the transfer position Do.
  • the shape, area, or area of the capillary can be varied to control the shape or area of the transferred nanoparticle assembly.
  • a method of detecting a substance to be detected comprising: separating a single layer of nanoparticles using a capillary and transferring the single layer to a substrate; And detecting a substance to be detected on the substrate from the Raman signal of the single layer of the transferred nanoparticles.
  • the transferring step includes the steps of forming a monolayer of nanoparticles at the interface between the liquid gas, contacting the capillary at the interface between the liquid gas to separate the monolayer of nanoparticles into a capillary, And transferring the nanoparticle monolayer to the substrate.
  • a capillary nanoparticle single layer transfer device comprising a capillary that separates a single layer of nanoparticles and then transfers to a substrate, as a nanoparticle single layer transfer device.
  • the apparatus comprises: a nanoparticle monolayer forming portion in which a monolayer of nanoparticles is formed at an interface between liquid gasses; And the capillary provided in the single-layer forming portion.
  • the method and apparatus can be usefully used to detect drugs or explosives on a garment surface or a bill surface, or to detect hazardous materials on a food surface.
  • a method of discriminating whether or not a banknote is counterfeited comprising: separating a single layer of nanoparticles using a capillary, and transferring a single layer of nanoparticles in the capillary to the original bill more than once; And discriminates that the banknote is genuine when the Raman signal of the single layer of the transferred nanoparticles is measured.
  • a method of manufacturing a microfluidic (microfluidic, microfluidic) channel comprising: using a capillary to separate a monolayer of nanoparticles and transition to a microfluidic channel, Channel fabrication method.
  • the exemplary embodiments of the present invention use capillary phenomenon to selectively separate a single layer of a single layer of nanoparticles into a small area. According to this, a reproducible transition of a single layer of uniform nanoparticles is possible regardless of the surface properties and structure of the solid substrate. In addition, it uses only commercially available glass capillary tubes without the need for highly specialized or specialized equipment, so the cost is low, the transition speed is very fast, and the accessibility is simple.
  • the method and apparatus of the present invention allow a single layer of nanoparticles to be transferred to the surface of paper such as fibrous clothes, various foods such as rice grains and oranges, paper money, etc., and high-speed field inspections of illegal drugs, explosives, , Counterfeit banknote prevention technology, and the like.
  • the nucleic acid was added to form an interface with the aqueous solution.
  • Metal nanoparticles are stable at the interface due to the energy due to the surface tension, but when only the nucleic acid is added, the electrostatic repulsion between the nanoparticles is stronger, so that the self-assembly phenomenon does not occur. Since ethanol weakens the charge of molecules surrounding the nanoparticle surface, it can induce self-assembly by reducing electrostatic repulsion.
  • a PDMS substrate having a length of 1 cm on one side was horizontally brought into contact with the interface where a single layer of nanoparticles existed, and then peeled off.
  • FIG. 2 is a photograph of a single layer of a spherical gold nanoparticle having a size of 50 nm existing at a water-air interface and a single layer thereof transferred to a PDMS substrate having a length of 1 cm on one side in the comparative example of the present invention.
  • the solid substrate having affinity with the nanoparticles was brought into contact with the interface horizontally and then peeled off.
  • a capillary of 12.5 cm in length and 10, 50, 100, and 200 ⁇ L in volume was vertically contacted with a monolayer of nanoparticles formed at the interface between the aqueous solution and the air interface, and the capillary was withdrawn after allowing the aqueous solution to rise above a certain amount into the capillary.
  • the withdrawn capillary was reversed and the solution in the capillary was forced down to the opposite direction inlet by gravity.
  • the capillary in this state was vertically brought into contact with the position where the PDMS and the glass substrate were to be transferred, and then peeled off.
  • FIGS. 3A through 3D illustrate photographs in which a monolayer of a gold nanoparticle having a size of 50 nm is transferred to PDMS substrates at various sizes using a capillary transfer technique in an embodiment of the present invention.
  • FIG. 3A through 3D illustrate photographs in which a monolayer of a gold nanoparticle having a size of 50 nm is transferred to PDMS substrates at various sizes using a capillary transfer technique in an embodiment of the present invention.
  • FIGS. 3A to 3D it can be seen that the area of the transition when the capillary having different diameters of the inlet is varied is different from that of the comparative example in which the capillary is not used, The layer was transferred.
  • Figures 4a and 4b show photographs of multiple nanoparticle monolayer simultaneous multiple transitions using a plurality of capillary packs. As shown in FIGS. 4A and 4B, it is possible to perform fine patterning such as 'NRG' because it is possible to precisely control the transition position through a capillary as well as a simple pattern.
  • Figures 5A-5F are UV data for six different types of nanoparticles in an embodiment of the invention.
  • FIGS. 6A to 6F show results obtained by transferring a monolayer of nanoparticles of various shapes and compositions to a glass substrate using a capillary tube, in an embodiment of the present invention, using a scanning electron microscope.
  • FIG. 6A to 6F show results obtained by transferring a monolayer of nanoparticles of various shapes and compositions to a glass substrate using a capillary tube, in an embodiment of the present invention, using a scanning electron microscope.
  • FIG. 6 it can be seen that a uniform single-layer structure in which particles are arranged at a high density is formed in all six types of nanoparticles.
  • FIGS. 7A to 7D show the results of transferring a single layer of nanoparticles to the surface of a leaf, which is a living body substrate having a soft surface, according to an embodiment of the present invention.
  • Figs. 7A and 7B are front and back surfaces of one leaf, respectively, and Figs. 7C and 7D are front and back surfaces of a different leaf, respectively.
  • FIG. 8 shows a scanning electron microscopic result of a gold nanoparticle monolayer transferred to a PDMS substrate coated with a high density of E. coli.
  • the PDMS precursor was poured and hardened in a preformed silicon mold through lithography, and a single layer of gold nanoparticles was transferred to a 1 mm diameter using a capillary tube inside the removed microfluidic channel.
  • Benzocaine solution to the clothing surface tinged with fibrous structures illegal drugs of cocaine and chemical structure is water similar substitutes (10 ⁇ M) to 30 ⁇ l of after dropping were completely dried, by using a capillary size 50nm spherical gold nanoparticles A single layer was transferred.
  • the surface curvature and pesticide (reldan) aqueous solution in which roughness is commercially available on a large grain of rice and orange peel surface 30 ⁇ l was then dropped completely dried, by using a capillary transfer a spherical gold nanoparticle monolayers, the size of 50nm.
  • the graph of the 14 pesticides in a grain of rice surface shows the selective appears only in Raman signal nanoparticle monolayer region (chlorpyrifos-methyl), the detection lower limit of the recommended use concentration of the pesticide by 10 ⁇ M 0.7 Much lower amounts of pesticides than 1.4mM are also detectable.
  • FIG. 15 shows a photograph of a single layer of nanoparticles transferred to the surface of a rough orange rind with a large curvature like rice grains.
  • a spherical gold nanoparticle monolayer having a size of 50 nm was transferred to a 1 mm diameter area at various positions on the surface of a US $ 100 bill, and then irradiated with a 785 nm laser for 3 seconds to obtain a surface enhanced Raman scattering signal Respectively.
  • Figures 18A-18J are Raman signal results showing that strong peaks near 250 cm < -1 > are common in all gold nanoparticle monolayer locations transferred to a $ 100 bill in an embodiment of the present invention.
  • Figures 18a through 18j illustrate the potential of counterfeit banknote prevention technology through the appearance of gold nanoparticle intrinsic optical signals in a single layer of spherical gold nanoparticles 50 nm in size transferred at various locations in a $ 100 bill.
  • This signal is a signal due to the Au-O bond of gold nanoparticles, suggesting the possibility of utilizing a single layer of nanoparticles transferred to a paper currency with a capillary as a small area code with a unique chemical signal that can not be counterfeited.
  • the single layer of nanoparticles can be transferred to an area of 1 mm or less in diameter, which is similar to the laser irradiation area, the efficiency of the number of nanoparticles can be greatly improved .
  • Transition is possible regardless of the composition and shape of the nanoparticles.
  • the nanoparticles For example, as shown in FIG. 6, not only gold nanoparticles having different shapes but also spherical gold nanoparticles of different sizes, core-shell structure nanoparticles having a silica shell on the surface, and silver nanoparticles having different compositions, Is possible.
  • transition can be made regardless of the composition and shape of the solid substrate to be transferred.
  • nanoparticles are efficiently transferred to glass and PDMS substrates, which are typical materials having hydrophilic property and hydrophobic surface property, Therefore, it was found that transition can be made to a rough or curved surface.
  • this technology transitions a single layer of nanoparticles by contact between the substrate surface and the liquid interface, allowing nondestructive transfer to substrates that are susceptible to destruction by pressure or to substrates that require delicate manipulation There are advantages.
  • transition process is simple, without requiring special equipment or high expertise of the tester compared with existing nanometer-level lithography, electrochemical deposition, or Langmuir-BlowJet techniques.
  • nanoparticle single layer transfer technology using the present capillary can transfer a single layer of nanoparticles to various solid surfaces such as paper, such as fiber clothes, various foods, cells, paper money, etc., It can be confirmed that this method can be used not only for the inspection and the high speed inspection of the illegal drug field but also for the counterfeiting prevention technology. This is expected to greatly expand the accessibility of nanoparticles with precisely controlled structures in each field of society that requires fast and sensitive molecular detection.
  • a single layer of nanoparticles can be relatively uniformly transferred in a simple manner without professional equipment, regardless of the surface properties and structure of the solid substrate, and thus limited in the laboratory environment
  • Existing nanoparticle monolayer transfer technology can be greatly extended to field detection in various fields such as biomedicine, forensics, and pharmaceuticals.

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Abstract

L'invention concerne un procédé et un dispositif destinés à transférer une monocouche de nanoparticules à l'aide d'un tube capillaire, une monocouche de nanoparticules présentes dans une interface liquide-gaz étant localement et sélectivement séparée puis transférée sur un substrat à l'aide du tube capillaire. En conséquence, un transfert non destructif et reproductible peut être effectué indépendamment des propriétés et des structures superficielles du substrat vers lequel la monocouche doit être transférée. Par conséquent, le procédé et le dispositif permettent une inspection à grande vitesse in situ de matériaux nocifs, tels qu'un médicament illégal et un pesticide résiduel, sur des surfaces de divers solides tels que des vêtements en fibre, des aliments et des billets de banque, et peut être facilement couplé à un canal microfluidique de petite taille et de structure complexe. En outre, le procédé et le dispositif peuvent transférer une monocouche de nanoparticules selon un procédé simple et peu coûteux sans utiliser un équipement spécial et coûteux.
PCT/KR2018/012422 2017-10-20 2018-10-19 Procédé et dispositif de transfert d'une monocouche de nanoparticules au moyen d'un tube capillaire WO2019078676A2 (fr)

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KR10-2017-0136396 2017-10-20
KR20170136396 2017-10-20
KR1020180116757A KR102086740B1 (ko) 2017-10-20 2018-10-01 모세관을 이용한 나노입자 단일층의 전이 방법 및 장치
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CN113540353B (zh) * 2021-06-21 2022-10-11 复旦大学 一种取向化气液界面聚合物半导体薄膜及其构筑方法和应用

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