WO2019068296A1 - Dispositif de pierre ponce pour le psoriasis - Google Patents

Dispositif de pierre ponce pour le psoriasis Download PDF

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Publication number
WO2019068296A1
WO2019068296A1 PCT/DK2018/050242 DK2018050242W WO2019068296A1 WO 2019068296 A1 WO2019068296 A1 WO 2019068296A1 DK 2018050242 W DK2018050242 W DK 2018050242W WO 2019068296 A1 WO2019068296 A1 WO 2019068296A1
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WO
WIPO (PCT)
Prior art keywords
preferred
sponge
abrasive material
psoriasis
phenolic
Prior art date
Application number
PCT/DK2018/050242
Other languages
English (en)
Inventor
Flemming Licht
Original Assignee
Unigroup Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unigroup Aps filed Critical Unigroup Aps
Priority to EP18786214.9A priority Critical patent/EP3691753A1/fr
Publication of WO2019068296A1 publication Critical patent/WO2019068296A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2025/00—Use of polymers of vinyl-aromatic compounds or derivatives thereof as moulding material
    • B29K2025/04—Polymers of styrene
    • B29K2025/06—PS, i.e. polystyrene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2075/00—Use of PU, i.e. polyureas or polyurethanes or derivatives thereof, as moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/04—Condition, form or state of moulded material or of the material to be shaped cellular or porous
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor

Definitions

  • the present invention relates to a device for the alleviation of symptoms of psoriasis.
  • a device for the alleviation of symptoms of psoriasis concerns a soft material, such as a sponge, having a surface, wherein said sponge is at least partly covered with and/or comprises pumice, for the topical treatment of psoriasis.
  • the patent US 3,383,280 relates to a dermatological abradant stick-type applicator, which purportedly is useful in treating skin blemishes.
  • the applicator comprises a solid wax matrix containing an antibacterial and an abradant.
  • a device which may be used for abrading skin affected by psoriasis.
  • a device is provided which upon use surprisingly suppresses the production of psoriasis scales and itching associated with psoriasis.
  • it has been possible to provide a device which does not scar the skin.
  • a device which may be used without any additional pharmaceutical or cosmetical substances, i.e. a device of the present invention may be used as a stand-alone device, without the need of pharmaceutical or cosmetical substances.
  • a device of the invention surprisingly exhibits a negative Koebner effect in preliminary experiments. Psoriasis is not spread upon use of the device. Further, use of the device does not provoke bleeding. This is the case upon use of e.g. conventional sand paper.
  • the present invention may provide a device further comprising vitamins and/or minerals which help in the treatment, prophylaxis and/or amelioration of psoriasis or symptoms associated with psoriasis and/or dry skin.
  • the present invention may provide a device wherein said device only requires a small volume under storage and transport and then expands, e.g. upon soaking in water, right before use. This makes storage and transport of the device easier.
  • the invention concerns a device according to claim 1.
  • the invention concerns a use of the device for the treatment, prophylaxis and/or amelioration of psoriasis or symptoms associated with psoriasis and/or dry skin.
  • the invention concerns the embodiments presented in the claims.
  • the invention concerns a device for the treatment, prophylaxis and/or amelioration of psoriasis or symptoms associated with psoriasis; said device comprising a body having a surface, wherein at least part of said surface comprises, consists of and/or is covered with an abrasive material.
  • the invention concerns a device, said device comprising a body having a surface, wherein part of said surface is removable, resulting in the appearance of a new, fresh surface.
  • the outer part of the device comprising at least part of the surface may be removed during normal use due to wear and/or tear, or it may be removed deliberately between uses, in order to present a new, fresh surface to be used. This may provide a device which may be used for a longer period of time.
  • An abrasive material may contain particles, for example, quartz sand, almond bran, polyethylene, aluminium trioxide, ground fruit cores (walnut or apricot shells), salt crystals, jojoba leaves, ground sepia shells, pumice, zeolites, and silicon dioxide.
  • particles for example, quartz sand, almond bran, polyethylene, aluminium trioxide, ground fruit cores (walnut or apricot shells), salt crystals, jojoba leaves, ground sepia shells, pumice, zeolites, and silicon dioxide.
  • An abrasive material may contain abrasive fibres, such as natural or synthetic fibres which have abrasive properties as a result of the nature of their surface, such as hardness or structure, or as a result of their dimensions, such as, for example, hemp, sisal, and coconut fibres.
  • abrasive fibres such as natural or synthetic fibres which have abrasive properties as a result of the nature of their surface, such as hardness or structure, or as a result of their dimensions, such as, for example, hemp, sisal, and coconut fibres.
  • An abrasive material may contain a mixture of particles and fibres.
  • the invention concerns a device, wherein said abrasive material has a Mohs hardness of 4-8.5, preferably 4.5-8, more preferred 5-7.5, preferably 5.5-7, more preferred 6- 6.5.
  • the invention concerns a device, wherein said abrasive material has a melting point of 250-4000, preferably 500-3500, more preferred 750-3000, preferably 1000-2500, more preferred 1200-2000, preferably 1400-1800, more preferred 1500-1700, preferably about 1600 °C.
  • the invention concerns a device, wherein said abrasive material comprises or consists of an amorphous material.
  • the invention concerns a device, wherein said abrasive material comprises or consists of pumice.
  • pumice While pumice is preferred other abrasive materials may be used. Particularly preferred are abrasive materials with abrasive properties similar or identical to the pumice used in the present application.
  • the invention concerns a device, wherein the fraction of said abrasive material which passes through a 300 micron sieve is 0-100, preferably 5-95, more preferred 10-90, preferably 15-85, more preferred 20-80, preferably 25-75, more preferred 30-70, preferably 35-65, more preferred 40-60, preferably 45-55 more preferred about 50 % by weight of the total amount of abrasive material.
  • the invention concerns a device, wherein the fraction of said abrasive material which passes through a 400 micron sieve is 50-100, preferably 70-99.5, more preferred 80- 99, preferably 90-98.5 more preferred about 98 % by weight of the total amount of abrasive material.
  • the invention concerns a device, wherein the fraction of said abrasive material which passes through a 200 micron sieve is 0-50, preferably 0.5-30, more preferred 1-20, preferably 1.5-10 more preferred about 2 % by weight of the total amount of abrasive material.
  • the invention concerns a device, wherein said abrasive material comprises 10-100, preferably 20-98, more preferred 30-95, preferably 40-90, more preferred 50-86, preferably 60-83, more preferred 65-80, preferably 70-78, more preferred 72-76, preferably about 74 weight% Si0 2 .
  • the invention concerns a device, wherein said abrasive material comprises 0-100, preferably 2-80, more preferred 4-60, preferably 6-40, more preferred 8-30, preferably 10-20, more preferred about 12 weight% Al 2 0 3 .
  • the invention concerns a device, wherein said abrasive material comprises 0-50, preferably 1-30, more preferred 2-20, preferably 3-10, more preferred 3.5-5, preferably about 4 weight% K 2 0.
  • the invention concerns a device, wherein said abrasive material comprises 0-50, preferably 1-30, more preferred 2-20, preferably 3-10, more preferred 3.5-5, preferably about 4 weight% Na 2 0.
  • the invention concerns a device, wherein said abrasive material comprises 0-50, preferably 0.2-30, more preferred 0.4-20, preferably 0.6-10, more preferred 0.8-6, preferably 1-4, more preferred 1.2-2, preferably about 1 weight% Fe 2 0 3 .
  • the invention concerns a device, wherein said abrasive material has a loss on ignition of 0-50, preferably 1-30, more preferred 2-20, preferably 3-10, more preferred 3.5-5, preferably about 4 weight%.
  • the invention concerns a device, wherein said body comprises or consists of a soft material, allowing said body to adapt its shape to curves and crevices of the body of a patient.
  • Devices for the removal of skin may be sponges, woven or nonwoven textiles supplied with abrasive particles, textiles containing abrasive fibres or particles, such as wash gloves with or without coconut or hemp fibres, sea cucumber skeleton (luffa), konjac ⁇ Amorphophallus konjac) and coarsely woven textiles.
  • a member of the phylum Porifera being a multicellular parazoan organism that has a body full of pores and channels allowing water to circulate through them, consisting of jelly-like mesohyl sandwiched between two thin layers of cells.
  • An item consisting of a soft, porous material that may find use as a cleaning aid. Sponges are especially good at absorbing water and water-based solutions.
  • the term "sponge” refers to the second of these groups, namely an item consisting of a soft, porous material that may find use as a cleaning aid. Sponges are especially good at absorbing water and water-based solutions.
  • Natural sponge may in general refer to either of the two different groups defined below: 1. Any product made of the skeletons of sea sponges in the phylum Porifera. These products are made up of a material called spongin. Spongin is a collagen protein which creates a fibrous structure for the organism.
  • Any sponge made of a natural and/or naturally occurring material is any sponge made of a natural and/or naturally occurring material.
  • natural sponge refers to the second of these groups, namely any sponge made of a natural and/or naturally occurring material.
  • Sponges may be natural or artificial. Natural sponges are, for example, konjac sponges, coral sponges or pumice sponges. Artificial sponges are, for example, large-pored viscose sponges, velour sponges, polyester sponges or polyether sponges. They have a mostly irregular cell structure and pores of varying size. They are flexible and elastic.
  • a konjac sponge is a sponge manufactured of Amorphophallus konjac.
  • a konjac sponge is a sponge manufactured of Amorphophallus konjac and/or calcium hydroxide and/or oxide calcium.
  • textiles refer to, but is not necessarily limited to, wipes, nonwovens, felt, knits, wovens, pads, but also cords, strings, ropes and threads.
  • a foam is a substance that is formed by trapping pockets of gas in a liquid or solid. In most foams, the volume of gas is large, with thin films of liquid or solid separating the regions of gas. Foams are examples of dispersed media. The term “foam” may also refer to anything that is analogous to such a foam, such as quantum foam, polyurethane foam (foam rubber), XPS foam, Polystyrene, phenolic, or many other manufactured foams.
  • the invention concerns the device, wherein the body comprises or consists of a sponge or foam, preferably a sponge.
  • Sponges are commonly made from e.g. Amorphophallus konjac, cellulose wood fibers or foamed plastic polymers. Some natural sponges are still sold, but most are now used either as body or facial sponges (bath sponges) or as tools for sponge painting. Bath sponges help cleanse the skin by scraping away the dead skin and washing away dirt.
  • the invention concerns a device, wherein the sponge expands upon soaking in water.
  • the invention concerns a device, wherein the sponge expands with 1- 100, preferably 5-90, more preferred 10-80, preferably 15-75, more preferred 20-70, preferably 25- 65, more preferred 25-60, preferably 30-60, more preferred 40-60% upon soaking in water.
  • a polyether sponge has a low density and the tensile force is not strong. This type of sponge is generally used in packaging, toys, clothing and home furnishing.
  • a PVA Sponge also referred to as Polyvinyl Alcohol (formalized) Sponge
  • PVA Sponge is a high tech plastic sponge that has many of the same properties and qualities of a natural sea sponge.
  • Static-free and lint-free, PVA Sponge is hydrophilic with porosities from 55% to 95%.
  • the surfaces of each sponge can be engineered for specific applications - from very smooth pores to large open pores like sea sponges. All deliver an exceptionally high volume and speed of absorption, holding many times the volume of liquid compared to a natural sea sponge. Additionally the sponge is highly resistant against strong acid, strong alkaline, heat and hot water. Elasticity and tensile properties provide durability and help safe application without giving any harmful effects.
  • a PVA sponge consists interconnected hollow cells and 90% of its volume is air.
  • Polyester sponges are subdivided into a variety of types, some of which are reticulated (artificially broken-in) for ease of use.
  • One type, double-blown polyester has high water-retention ability approaching or equaling that of PVA sponges, but with visible pores and more diverse uses.
  • the invention concerns a device, wherein the sponge is an artificial sponge or a natural sponge.
  • the invention concerns a device, wherein the sponge is a natural sponge.
  • the invention concerns a device, wherein the sponge is an artificial sponge.
  • the invention concerns a device, wherein said sponge is selected among a konjac sponge, a cellulose wood fiber sponge, a foamed plastic polymer sponge, a low- density polyether sponge, a PVA sponge, a polyester sponge, or a mixture of any of these.
  • the invention concerns a device, wherein the sponge is made from a material selected among Amorphophallus konjac, konjac glucomannan, cellulose, melamine, animal, and loofa.
  • the invention concerns a device, further comprising calcium hydroxide and/or oxide calcium
  • the invention concerns a device, wherein the sponge comprises at least one material selected among Amorphophallus Konjac, calcium hydroxide and oxide calcium.
  • a PVA sponge with interconnected pores may be made by reacting polyvinyl alcohol and formaldehyde.
  • the procedure further includes providing an aqueous solution of formaldehyde, polyvinyl alcohol containing less than 10% residual hydrolyzable material in the molecule, an acid catalyst, in which the acid functional group is inorganic and have a dissociation constant of at least 10 "2 as well as a froth-stabilizing wetting agent, which is soluble in and substantially stable in the resulting solution.
  • the invention concerns a device, wherein said sponge is made by reacting polyvinyl alcohol, preferably in the form of a solution containing less than 10% residual hydrolyzable material in the molecule, with formaldehyde, preferably in an aqueous solution.
  • the invention concerns a device, wherein said sponge is a PVA sponge made by utilizing an acid catalyst, preferably comprising an inorganic acid functional group with a dissociation constant of at least 10 "2 .
  • the invention concerns a device, wherein said sponge is a PVA sponge made in a solution comprising a froth-stabilizing wetting agent, which preferably is soluble and substantially stable in the said solution.
  • the invention concerns a device, wherein said sponge is made from a material selected among cellulose, melamine, animal, and loofa.
  • Viscose is an alkaline solution of alkali cellulose xanthogenate which can be mixed with a pore- forming material and reinforcing fibers to produce cellulose sponges according to US 2,914,493.
  • the invention concerns a device, wherein said sponge is made from a mixture of viscose, a pore-forming material and reinforcing fibers.
  • Pore-forming materials are salt crystals such as sodium sulfate decahydrate or other substances which melt or dissolve easily.
  • the pore-forming substance may be selected as to size and shape so as to produce a texture very similar to natural sponges.
  • the sodium sulfate decahydrate crystals are present in the sponge-forming material in an amount about 50-90% by weight thereof, although the amount may vary considerably.
  • the invention concerns a device, wherein said sponge is from a mixture containing sulfate decahydrate as a pore-forming material, preferably in a concentration of 50-90% by weight.
  • the invention concerns a device, wherein said sponge is from a mixture containing reinforcing fibers such as jute, hackled flax or hemp, rayon, cotton, and polyester fibers.
  • reinforcing fibers such as jute, hackled flax or hemp, rayon, cotton, and polyester fibers.
  • the total fiber content may amount to 0.5-3.0% of the total sponge forming mixture. Larger contents of reinforcing fibers tend to make a stronger sponge at the expense of absorbent ability. Below 0.5% fiber content the strength of the sponge decreases.
  • the invention concerns a device, wherein said sponge is from a mixture with a fiber content of 0.5-3.0% of the total sponge forming mixture.
  • the invention concerns a device, wherein said sponge is from a mixture containing reinforcing fibers, wherein 5-30% of the reinforcing fibers consist of polyester fibers.
  • the invention concerns a device, wherein said device further comprises at least one mineral or vitamin.
  • the invention concerns a device, wherein said device further comprises at least one compound selected from the group consisting of sodium, potassium, magnesium, iron, phosphorus, copper, zinc, vitamin A, vitamin E, vitamin D, vitamin Bl, vitamin B2, vitamin B6, vitamin B12, vitamin C, pantothenate, niacin, fatty acids, folic acid, dietary fibers and amino acids.
  • the invention concerns a device, wherein said body has a
  • the invention concerns a device, wherein said body has a rounded upper part and a flat bottom part.
  • the invention concerns a device, wherein said body has a longest longitudinal length of 2-25, preferably 3-20, more preferred 5-15, preferably about 10 cm.
  • This embodiment provides a size which is easy to handle with one hand.
  • the invention concerns a device, wherein at least part of said device comprises, consists of and/or is covered with an abrasive material.
  • the invention concerns a device, wherein said abrasive material is adhered or bond to said body with an adhesive or where said abrasive material is incorporated in the sponge.
  • the invention concerns a device, wherein said abrasive material is adhered or bond to said body with an adhesive.
  • the invention concerns a device, wherein said abrasive material is incorporated in the sponge.
  • Adhesive is used in the literature about glue, cement, mucilage, or paste, and is any substance which may be applied to one surface, or both surfaces, of two separate items that binds them together and resists their separation.
  • the invention concerns a device, wherein said adhesive is a paste.
  • Paste is used here about a soft, smooth, and plastic material or preparation.
  • the paste preferably allows mixing with abrasive particles or fibers. After mixing, the paste mixture may be applied to the body of the device providing a cover of paste mixture of a few millimeters, such as 3 mm.
  • the invention concerns a device, wherein said adhesive is selected among thermosetting, thermoplastic, elastomeric and alloy adhesives.
  • the invention concerns a device, wherein said adhesive is selected among elastomeric and alloy adhesives.
  • the invention concerns a device, wherein said adhesive comprises or is selected among the group consisting of Cyanoacrylates, Epoxy, Polyester, Polyimide, Urea- formaldehyde, Polybenzimidazole, Melamine-formaldehyde, Acrylic, Resorcinol, Acrylic acid diester, Resorcinol-phenol-formaldehyde, Cellulose acetate, Polyvinyl acetals, Cellulose acetate butyrate, Polyvinyl alcohol, Cellulose nitrate, Polyamide, Polyvinyl acetate, Polyvinyl chloride, Phenoxy,
  • Polyvinylidene chloride Natural rubber, Styrene-butadiene rubber, Reclaimed rubber, Polyurethane, Butyl rubber, Polysulfide, Polyisobutylene, Silicone, Nitrile rubber, Neoprene, Epoxy-phenolic, Neoprene-phenolic, Epoxy-polysulfide, Vinyl-phenolic, Epoxy-nylon, Polyvinyl acetal-phenolic, and Nitrile-phenolic.
  • the invention concerns a device, wherein said adhesive comprises or is selected among the group consisting of Natural rubber, Styrene-butadiene rubber, Reclaimed rubber, Polyurethane, Butyl rubber, Polysulfide, Polyisobutylene, Silicone, Nitrile rubber, Neoprene, Epoxy- phenolic, Neoprene-phenolic, Epoxy-polysulfide, Vinyl-phenolic, Epoxy-nylon, Polyvinyl acetal- phenolic, and Nitrile-phenolic.
  • said adhesive comprises or is selected among the group consisting of Natural rubber, Styrene-butadiene rubber, Reclaimed rubber, Polyurethane, Butyl rubber, Polysulfide, Polyisobutylene, Silicone, Nitrile rubber, Neoprene, Epoxy- phenolic, Neoprene-phenolic, Epoxy-polysulfide, Vinyl-phenolic, Epoxy-nylon, Polyvinyl acetal- phenolic, and Nitrile-phenolic
  • Adhesives Technology Handbook (2nd Edition, Ed. Sina Ebnesajjad) adhesives may be classified from a number of points. Adhesives are either produced from a natural source such as starch glue or, as is the case with the majority of consumptions, they are synthesized from basic hydrocarbons.
  • the synthetic group consists of thermoplastic and thermosetting adhesives, both of which follow the definitions used in plastics for thermoplastic and thermosetting polymers.
  • Adhesives may inter alia be classified by chemical composition as thermosetting, thermoplastic, elastomeric, or combinations of these types (alloys).
  • the following adhesives are mentioned as examples of thermosetting adhesives: Cyanoacrylates, Epoxy, Polyester, Polyimide, Urea- formaldehyde, Polybenzimidazole, Melamine-formaldehyde, Acrylic, Resorcinol, Acrylic acid diester, and Resorcinol-phenol-formaldehyde.
  • thermoplastic adhesives Cellulose acetate, Polyvinyl acetals, Cellulose acetate butyrate, Polyvinyl alcohol, Cellulose nitrate, Polyamide, Polyvinyl acetate, Acrylic, Polyvinyl chloride, Phenoxy, and Polyvinylidene chloride.
  • elastomeric adhesives Natural rubber, Styrene-butadiene rubber, Reclaimed rubber, Polyurethane, Butyl rubber, Polysulfide, Polyisobutylene, Silicone, Nitrile rubber, and Neoprene.
  • alloy adhesives Epoxy-phenolic, Neoprene-phenolic, Epoxy-polysulfide, Vinyl-phenolic, Epoxy-nylon, Polyvinyl acetal-phenolic, and Nitrile-phenolic.
  • such adhesives may be used for the present invention.
  • elastomeric adhesives or adhesive alloys are preferred.
  • Adhesives can be subdivided by their form such as liquid, powder, film, or paste. Paste adhesives have high viscosities to allow application on vertical surfaces with little tendency to sag or drip. These bodied adhesives can serve as gap fillers and sealants.
  • the adhesive is a paste adhesive.
  • the invention concerns a device, wherein said adhesive has a natural or synthetic source of origin.
  • Adhesives may contain a number of components in addition to the adhesive materials.
  • a hardener is a substance added to an adhesive to promote the curing reaction by taking part through catalysis or cross-linking.
  • the invention concerns a device, wherein said adhesive comprises a hardener.
  • Solvents are sometimes used to reduce the viscosity of the adhesive to enhance its spreadability. Often a mixture of solvents is used to achieve the desired processability characteristics such as controlled solvent evaporation and removal. This can be accomplished by combining solvents with variable volatilities.
  • the invention concerns a device, wherein said adhesive comprises a solvent.
  • Diluents are liquid ingredients added to an adhesive to reduce the concentration of the binder component. Diluents are added principally to lower the viscosity and to modify the processing conditions of some adhesives. Reactive diluents do not evaporate, as would solvents. They react with the binder during the cure cycle and are incorporated in the cured adhesive.
  • the invention concerns a device, wherein said adhesive comprises a diluents.
  • Fillers are relatively neutral substances added to the adhesive to improve its working properties, strength, permanence, or other qualities. Fillers are also intended to reduce materials costs.
  • Fillers are used to modify adhesives to govern such properties as thermal expansion, electrical and thermal conductivity, shrinkage, and heat resistance.
  • the invention concerns a device, wherein said adhesive comprises a filler.
  • the invention concerns a device, wherein said adhesive comprises additives such as plasticizers, accelerators, inhibitors, retarders, tackifiers, thickeners, film formers, antioxidants, antifungal agents, and/or surfactants.
  • additives such as plasticizers, accelerators, inhibitors, retarders, tackifiers, thickeners, film formers, antioxidants, antifungal agents, and/or surfactants.
  • the invention concerns a device, wherein said adhesive and said abrasive material are intimately mixed, preferably before application to said body.
  • a device according to the present invention is obtainable by mixing an adhesive with abrasive material, and applying the mixture to a body.
  • the invention concerns a device, wherein said adhesive constitute a layer with a thickness of 0.1-50, preferably 0.2-30, more preferred 0.5-20, preferably 1-10, more preferred 1.5-5, preferably 2-4, more preferred about 3 mm.
  • the invention concerns a use of a device of the invention for the treatment, prophylaxis and/or amelioration of psoriasis or symptoms associated with psoriasis.
  • the invention concerns the use, wherein said use is topical use.
  • the invention concerns the use on a site selected among the group consisting of Armpits, Elbows, Feet, Groin, Hands, Knees, Lower back, Most of the body, Nails, Scalp, Skin folds around the genitals and buttocks, Thighs, Trunk, Under the breasts, behind and inside the ears, and Upper arms.
  • the invention concerns the use, wherein the psoriasis is selected among the group consisting of Erythrodermic Psoriasis, Guttate Psoriasis, Inverse Psoriasis, Nail Psoriasis, Plaque Psoriasis, Psoriatic Arthritis, and Pustular Psoriasis.
  • the psoriasis is selected among the group consisting of Erythrodermic Psoriasis, Guttate Psoriasis, Inverse Psoriasis, Nail Psoriasis, Plaque Psoriasis, Psoriatic Arthritis, and Pustular Psoriasis.
  • an abrasive material such as pumice, according to the invention, may be used incorporated in a foam, a creme, a shampoo, or a similar composition, for the treatment or prophylaxis of an indication mentioned in the present application, in particular psoriasis.
  • Fig. 1 shows a schematic representation of an embodiment of a device (10) according to the invention.
  • the device comprises a body (12), wherein a part (14) of the surface of the body is covered with pumice particles.
  • Fig. 2 shows a schematic representation of an embodiment of a device (10) according to the invention.
  • the device comprises a body (12) having a round upper part and a flat bottom part, wherein a part (14) of the surface of the body comprises pumice particles.
  • Fig. 3 shows a plot of the particle size distribution showing the cumulative percentage passing by weight versus micron.
  • Example 1 Unless otherwise mentioned, all percentages are in weight/weight. Unless otherwise mentioned, all measurements are conducted under standard conditions (ambient temperature and pressure). Example 1
  • a mixture was made of pumice and a paste of a polymer dispersion.
  • the paste is a ready-mixed waterproofing material based on polymer dispersion. It is usually used as a sealing membrane. In the present example it is used as an adhesive.
  • pumice had a Mohs hardness of 6-6.5, and a melting point of about 1600°C, and carries the trade name NMP-16 from Richard Baker Harrison ltd. According to the product description, pumice is a light weight natural alumina silicate of volcanic origin, light grey in colour. The pumice is further described as an inert, pozzalanic, foamed material exhibiting high mechanical strength and low density.
  • a plot of the particle size distribution showing the cumulative percentage passing by weight versus micron indicates that about 50% by weight would pass a sieve size of 300 microns.
  • An oblong sponge with a cylindrical cross section was covered, on one of the surfaces having a cylindrical shape, with a 3 mm thick layer of the mixture of pumice and paste.
  • the mixture of pumice and paste was allowed to cure.
  • the sponge was used efficaciously topically on spots of skin affected by psoriasis for the alleviation of the symptoms of psoriasis, without the application of additional pharmaceutical substances topically. Surprisingly, this use left no scars and removed scales without itching.
  • a mixture was made of pumice and konjac.
  • the mixture was poured into a mold and allowed to solidify into a hardened texture followed by alkali heat solidification to complete the hardening process.
  • the mixture was placed in a tank of water to slowly cool down. Afterwards, the mixture was subjected to repeated cycles of freeze drying and thawing yielding the konjac sponges.
  • the konjac sponges were washed and sterilized.
  • pumice had a Mohs hardness of 6-6.5, and a melting point of about 1600°C, and carries the trade name NMP-16 from Richard Baker Harrison ltd. According to the product description, pumice is a light weight natural alumina silicate of volcanic origin, light grey in colour. The pumice is further described as an inert, pozzalanic, foamed material exhibiting high mechanical strength and low density.
  • the obtained konjac sponges were suitable for topical use in the treatment of skin affected by psoriasis for the alleviation of the symptoms of psoriasis, without the application of additional pharmaceutical substances topically.

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Abstract

La présente invention concerne un dispositif de soulagement des symptomes du psoriasis. En particulier, elle concerne un matériau souple, tel qu'une éponge, ayant une surface au moins partiellement recouverte avec de la pierre ponce ou comprenant de la pierre ponce pour le traitement topique du psoriasis.
PCT/DK2018/050242 2017-10-03 2018-10-01 Dispositif de pierre ponce pour le psoriasis WO2019068296A1 (fr)

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DKPA201770750 2017-10-03

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3679916A4 (fr) * 2017-09-08 2021-06-02 Wuhan Bebevisa Biotech Co., Ltd Éponge de gommage et son procédé de préparation

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Publication number Priority date Publication date Assignee Title
US2609347A (en) 1948-05-27 1952-09-02 Wilson Christopher Lumley Method of making expanded polyvinyl alcohol-formaldehyde reaction product and product resulting therefrom
US2914493A (en) 1956-02-24 1959-11-24 American Enka Corp Cellulose sponge composition containing polyethylene terephthalate fiber and method of making
US3383280A (en) 1963-01-09 1968-05-14 Miles Lab Dermatological abradant stick-type applicator
US7060119B1 (en) * 2003-05-14 2006-06-13 Footzee, Inc. Therapeutic abrasive sponge
US7219387B1 (en) * 2004-02-17 2007-05-22 Toby Curtis Moore Foot cleansing device
KR20110052957A (ko) * 2009-11-13 2011-05-19 김정화 숯이 함유된 미용스폰지 제조방법
US20120323257A1 (en) * 2011-06-02 2012-12-20 Sutton Bernard S Soft-pedicare

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Publication number Priority date Publication date Assignee Title
US2609347A (en) 1948-05-27 1952-09-02 Wilson Christopher Lumley Method of making expanded polyvinyl alcohol-formaldehyde reaction product and product resulting therefrom
US2914493A (en) 1956-02-24 1959-11-24 American Enka Corp Cellulose sponge composition containing polyethylene terephthalate fiber and method of making
US3383280A (en) 1963-01-09 1968-05-14 Miles Lab Dermatological abradant stick-type applicator
US7060119B1 (en) * 2003-05-14 2006-06-13 Footzee, Inc. Therapeutic abrasive sponge
US7219387B1 (en) * 2004-02-17 2007-05-22 Toby Curtis Moore Foot cleansing device
KR20110052957A (ko) * 2009-11-13 2011-05-19 김정화 숯이 함유된 미용스폰지 제조방법
US20120323257A1 (en) * 2011-06-02 2012-12-20 Sutton Bernard S Soft-pedicare

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Title
"Adhesives Technology Handbook"
"Handbook of Adhesive Technology"
"Mohs' Hardness of Abrasives", INTERNET CITATION, 2006, pages 1 - 6, XP002738049, Retrieved from the Internet <URL:http://www.reade.com/Particle_Briefings/mohs_hardness_abrasive_grit.html> [retrieved on 20150401] *
"Particle Size - US Sieve Series and Tyler Mesh Size Equivalents", 15 May 2002 (2002-05-15), XP055177436, Retrieved from the Internet <URL:http://www.azom.com/article.aspx?ArticleID=1417> [retrieved on 20150318] *
DATABASE WPI Week 201205, 2012 Derwent World Patents Index; AN 2011-G94356, XP002786682 *
EDWARD M. PETRIE: "Handbook of Adhesives and Sealants"

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3679916A4 (fr) * 2017-09-08 2021-06-02 Wuhan Bebevisa Biotech Co., Ltd Éponge de gommage et son procédé de préparation
US11529305B2 (en) 2017-09-08 2022-12-20 Wuhan Bebevisa Biotech Co., Ltd Scrub sponge and preparation method therefor

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