WO2019066421A3 - Dna 복제수 변이 기반의 암 종 예측 방법 - Google Patents

Dna 복제수 변이 기반의 암 종 예측 방법 Download PDF

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WO2019066421A3
WO2019066421A3 PCT/KR2018/011286 KR2018011286W WO2019066421A3 WO 2019066421 A3 WO2019066421 A3 WO 2019066421A3 KR 2018011286 W KR2018011286 W KR 2018011286W WO 2019066421 A3 WO2019066421 A3 WO 2019066421A3
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cancer
kinds
copy number
number variation
dna copy
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PCT/KR2018/011286
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WO2019066421A2 (ko
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김광현
이동환
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이화여자대학교 산학협력단
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Publication of WO2019066421A2 publication Critical patent/WO2019066421A2/ko
Publication of WO2019066421A3 publication Critical patent/WO2019066421A3/ko

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    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00—Machine learning
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

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  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
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  • Computer Vision & Pattern Recognition (AREA)
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  • Artificial Intelligence (AREA)
  • Genetics & Genomics (AREA)
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  • General Physics & Mathematics (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract

본 발명은 DNA 복제수 변이 기반의 암 종 예측 방법에 관한 것이다. 본 발명에 따른 DNA 복제수 변이 기반의 암 종 분류 모형, 암 종 예측 모형 및 이를 이용한 DNA 복제수 변이 기반의 암 종 예측 방법은 적절한 기계학습 알고리즘을 활용함으로써 통상적인 방법보다 비침습적이며 높은 민감도 및 특이도로 암 종을 예측 및 암을 진단할 수 있다. 특히, 본 발명은 하나의 예측 모형을 이용하여 다양한 암 종의 예측 및 암의 진단을 가능하게 하며, 이상적인 진단검체인 소변, 혈액 등을 이용한 액상 생검에 적용 가능하여 향후 암 진단 및 유전체 시장에서 유용하게 활용될 수 있다.
PCT/KR2018/011286 2017-09-27 2018-09-21 Dna 복제수 변이 기반의 암 종 예측 방법 WO2019066421A2 (ko)

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KR20170125441 2017-09-27
KR10-2017-0125441 2017-09-27

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WO2019066421A2 WO2019066421A2 (ko) 2019-04-04
WO2019066421A3 true WO2019066421A3 (ko) 2019-07-04

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CN110289047B (zh) * 2019-05-15 2021-06-01 西安电子科技大学 基于测序数据的肿瘤纯度及绝对拷贝数预测方法及系统
CN111145912B (zh) * 2019-12-23 2023-04-18 浙江大学 一种基于机器学习的个性化超促排卵方案的预测装置
CN111402951B (zh) * 2020-03-17 2022-07-12 至本医疗科技（上海）有限公司 拷贝数变异预测方法、装置、计算机设备和存储介质
KR102157613B1 (ko) * 2020-06-05 2020-09-18 현대엔지니어링(주) 기계학습을 이용한 자동화 철골구조물 설계 시스템 및 방법
US20220084631A1 (en) 2020-09-17 2022-03-17 Korea Advanced Institute Of Science And Technology Method and apparatus for machine learning based identification of structural variants in cancer genomes
KR102404947B1 (ko) 2020-09-17 2022-06-10 주식회사 지놈인사이트 기계학습 기반의 유전체 구조 변이 식별 방법 및 장치
KR20220074088A (ko) * 2020-11-27 2022-06-03 주식회사 지씨지놈 인공지능 기반 암 진단 및 암 종 예측방법
KR20220160806A (ko) * 2021-05-28 2022-12-06 주식회사 지씨지놈 세포유리 핵산단편 말단 서열 모티프 빈도 및 크기를 이용한 암 진단 및 암 종 예측방법
KR20220160807A (ko) * 2021-05-28 2022-12-06 주식회사 지씨지놈 세포유리 핵산과 이미지 분석기술 기반의 암 진단 및 암 종 예측 방법
CN113604544B (zh) * 2021-08-03 2023-03-10 北京大学口腔医学院 一种生物材料功能预测评价方法
CN113838533B (zh) * 2021-08-17 2024-03-12 福建和瑞基因科技有限公司 一种癌症检测模型及其构建方法和试剂盒
KR20230059423A (ko) * 2021-10-26 2023-05-03 주식회사 지씨지놈 메틸화된 무세포 핵산을 이용한 암 진단 및 암 종 예측방법
KR20230064172A (ko) * 2021-11-03 2023-05-10 주식회사 지씨지놈 세포유리 핵산단편 위치별 서열 빈도 및 크기를 이용한 암 진단 방법
WO2023102142A1 (en) * 2021-12-02 2023-06-08 AiOnco, Inc. Approaches to reducing dimensionality of genetic information used for machine learning and systems for implementing the same
KR102477860B1 (ko) * 2021-12-15 2022-12-14 가천대학교 산학협력단 대장암 예측을 위한 세부유전자정보 선택방법 및 시스템
KR20230114952A (ko) * 2022-01-26 2023-08-02 권창혁 암 판별 장치 및 암 판별 방법
KR20230135782A (ko) 2022-03-17 2023-09-26 한국전자통신연구원 유전자 데이터를 활용하여 종양을 분류하기 위한 기계학습 장치 및 방법
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KR20190036494A (ko) 2019-04-04
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