WO2019066325A3 - Composition for alleviating alopecia, comprising apigenin having improved solubility - Google Patents

Composition for alleviating alopecia, comprising apigenin having improved solubility Download PDF

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Publication number
WO2019066325A3
WO2019066325A3 PCT/KR2018/010747 KR2018010747W WO2019066325A3 WO 2019066325 A3 WO2019066325 A3 WO 2019066325A3 KR 2018010747 W KR2018010747 W KR 2018010747W WO 2019066325 A3 WO2019066325 A3 WO 2019066325A3
Authority
WO
WIPO (PCT)
Prior art keywords
apigenin
composition
improved solubility
alleviating alopecia
alopecia
Prior art date
Application number
PCT/KR2018/010747
Other languages
French (fr)
Korean (ko)
Other versions
WO2019066325A2 (en
Inventor
인병규
Original Assignee
(주)아모레퍼시픽
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by (주)아모레퍼시픽 filed Critical (주)아모레퍼시픽
Priority to JP2020507990A priority Critical patent/JP7146900B2/en
Priority to CN201880063434.2A priority patent/CN111194208B/en
Publication of WO2019066325A2 publication Critical patent/WO2019066325A2/en
Publication of WO2019066325A3 publication Critical patent/WO2019066325A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed is a composition for alleviating alopecia, comprising apigenin having improved solubility, in which the solubility of apigenin has been improved in order to increase the concentration of apigenin in the composition. The composition for alleviating alopecia, comprising apigenin having improved solubility, comprises, as active ingredients: apigenin; a polar oil; a polyol; and a monovalent alcohol, wherein the cLog P value of the polar oil is 1-5.
PCT/KR2018/010747 2017-09-28 2018-09-13 Composition for alleviating alopecia, comprising apigenin having improved solubility WO2019066325A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2020507990A JP7146900B2 (en) 2017-09-28 2018-09-13 Hair loss relief composition containing apigenin with improved solubility
CN201880063434.2A CN111194208B (en) 2017-09-28 2018-09-13 Composition for alleviating hair loss containing apigenin with improved solubility

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170125657A KR102417319B1 (en) 2017-09-28 2017-09-28 Alopecia relaxation composition including an apigenin with improved solubility
KR10-2017-0125657 2017-09-28

Publications (2)

Publication Number Publication Date
WO2019066325A2 WO2019066325A2 (en) 2019-04-04
WO2019066325A3 true WO2019066325A3 (en) 2019-05-23

Family

ID=65903372

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/010747 WO2019066325A2 (en) 2017-09-28 2018-09-13 Composition for alleviating alopecia, comprising apigenin having improved solubility

Country Status (5)

Country Link
JP (1) JP7146900B2 (en)
KR (1) KR102417319B1 (en)
CN (1) CN111194208B (en)
TW (1) TWI793178B (en)
WO (1) WO2019066325A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210142254A (en) 2020-05-18 2021-11-25 (주)아모레퍼시픽 Food composition with improved dissolution rate of apigenin

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060067905A1 (en) * 2005-04-01 2006-03-30 Sederma Sas Formulations and method for treating baldness
US20150335560A1 (en) * 2012-12-21 2015-11-26 L'oreal Cosmetic composition
KR101734424B1 (en) * 2010-10-22 2017-05-12 비쭈리 헬스 사이언스 엘엘씨 Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds
WO2017094905A1 (en) * 2015-12-02 2017-06-08 金印株式会社 Hair restoration/growth stimulating agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5089887B2 (en) 2006-01-23 2012-12-05 日本精化株式会社 Bioactive substance-containing complex
JP6343847B2 (en) 2013-12-24 2018-06-20 花王株式会社 Water absorbent resin and method for producing the same
JP6420969B2 (en) 2014-05-22 2018-11-07 株式会社 沖縄リサーチセンター Polymethoxyflavonoid-dissolving composition and method for producing the same
CN107158386A (en) * 2017-05-31 2017-09-15 段新方 Prevent and treat the medicine of alopecia

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060067905A1 (en) * 2005-04-01 2006-03-30 Sederma Sas Formulations and method for treating baldness
KR101734424B1 (en) * 2010-10-22 2017-05-12 비쭈리 헬스 사이언스 엘엘씨 Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds
US20150335560A1 (en) * 2012-12-21 2015-11-26 L'oreal Cosmetic composition
WO2017094905A1 (en) * 2015-12-02 2017-06-08 金印株式会社 Hair restoration/growth stimulating agent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHAKEEL, FAIYAZ: "Solubility and thermodynamic parameters of apigenin in different neat solvents at different temperatures", JOURNAL OF MOLECULAR LIQUIDS, vol. 234, no. 2017, 18 March 2017 (2017-03-18) - May 2017 (2017-05-01), pages 73 - 80, XP055613921 *

Also Published As

Publication number Publication date
KR102417319B1 (en) 2022-07-06
JP2020535115A (en) 2020-12-03
JP7146900B2 (en) 2022-10-04
TWI793178B (en) 2023-02-21
CN111194208A (en) 2020-05-22
CN111194208B (en) 2023-03-31
KR20190036592A (en) 2019-04-05
WO2019066325A2 (en) 2019-04-04
TW201919591A (en) 2019-06-01

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