WO2019050109A1

WO2019050109A1 - Microneedle patch having improved microneedle protection performance and microneedle patch applicator system including same microneedle patch and applicator

Info

Publication number: WO2019050109A1
Application number: PCT/KR2018/001888
Authority: WO
Inventors: 김홍기; 김정동; 이부용; 김태형; 정도현
Original assignee: 주식회사 라파스
Priority date: 2017-09-06
Filing date: 2018-02-13
Publication date: 2019-03-14
Also published as: KR20190027233A

Abstract

A microneedle patch (10) according to the present invention may comprise: a microneedle (11) formed on a lower portion thereof; a sheet (12) having an adhesive agent formed in at least the periphery of a region where the microneedle (11) is formed; an adhesive agent (13) formed on an upper portion of the sheet (12); a protective film (15) for protecting the adhesive agent (13) formed on the upper portion of the sheet (12); and a needle protective cap attached to a lower portion of the sheet (12) to protect the microneedle (11).

Description

A micro needle patch with improved micro needle protection and a micro needle patch applicator system consisting of such a micro needle patch and an applicator

The present invention relates to a micro needle patch with improved micro needle protection and a micro needle patch applicator system comprising such a micro needle patch and an applicator.

The skin covers the outside of the body and protects the muscles and organs inside the body. It is composed of three layers of outer skin, dermis and subcutaneous fat layer from outer side and functions as a barrier to body temperature control and external environment have. The epidermis is mostly keratinocytes, and melanocytes, Langerhans cells, amorphous cells and Merkel cells are also present. The stratum corneum is the first of the human body to perform barrier function (selective permeable membrane, physical shield, ultraviolet shield, harmful substance shield, microbial shield), moisturizing function, immune function, antioxidant function, anti-inflammatory function, antibacterial function, It is a shield.

There is a waterproof membrane on the lower part of the stratum corneum and the upper part of the management layer, and most of the active material does not pass through the waterproof membrane. To overcome this problem, it is necessary to 1) reduce the particle size of the active substance or add nano-carriers together, 2) pass waterproof membrane through physical, chemical and mechanical methods, or 3) formulate liposome, nano emulsion, So that it can pass through the stratum corneum. Products that maintain the intercellular lipid layer, which is most important for the barrier function and moisturizing function of the stratum corneum, and which penetrate the active material should be amphipathic (nano oil water type) itself, less than 100 nm in size, and less than 500 months in molecular weight. It can pass through the geological layer.

Thus, it is very difficult to deliver a desired substance unless the drug passes through the stratum corneum, which is the primary barrier, through the skin. Ointment and cream formulations designed to treat skin conditions are designed to allow the drug to pass through these stratum corneum and deliver the appropriate effects to the target site. However, as described above, even if the drug has a molecular weight of more than 500 daltons or its structure is difficult to pass through the stratum corneum, it is difficult to expect a desired purpose and efficacy even though it is limitedly designed.

Thus, microneedle technology has been commercialized to form an artificial channel in the stratum corneum of the skin to deliver the desired drug more efficiently.

1 shows a prior art applicator (hereinafter referred to as a " microneedle patch applicator ") for applying a patch with a microneedle formed thereon to the skin. The micro needle patch applicator shown in FIG. 1 is disclosed by US 2008/0009811 A1 of 3M Innovative Properties Company.

First, the microneedle patch is prepared as shown in the left side of FIG. As shown in the center view of FIG. 1, this circular patch is disposed in the column portion 34, and is inserted into the column portion 34 from left to right in the separated state of the column portion 34 separable from the applicator body. And is caught by the latching jaw 50 indicated by the reference numeral 50 in the right figure. When the post 34 is assembled to the applicator in this state, the micro needle patch applicator is ready for use.

1, the elastic force of the spring 44 pushes the piston 42 to the right, but the switch 36 connected to the piston 42 does not advance the piston 42 in the locking position It is blocking. At this time, when the user presses the switch 36 down to release the locking, the piston 42 is advanced by the elastic force of the spring 44, as shown in the right side of Fig. 1, (50) and presses it against the user's skin. The micro needles formed in the micro needle patch penetrate into the skin of the user due to the uniform pressing force by the elastic force of the spring 44 and the penetration state of the micro needle into the skin is controlled by the adhesive surface 24 formed on the patch, As shown in FIG.

However, the above-described prior art micro needle patch applicator has a problem that there is a high possibility that the micro needle is contaminated due to lack of proper protection means for the micro needle in the process of attaching the micro needle patch to the applicator. In addition, the adhesive surface 24 may be easily contaminated, and the adhesion to the skin may be lowered, so that the maintenance effect of the micro needle patch may be reduced. In addition, there is a high possibility that the micro needle is bent or broken during the process of attaching the micro needle patch to the applicator. If the micro needle is bent or broken, the number of microneedles that penetrate into the skin is reduced, thereby limiting the ability to penetrate the skin with the correct amount of drug.

In addition, since there is no appropriate protection means even when the microneedle patch is mounted on the applicator, there is a possibility that the microneedle is contaminated due to exposure to air or the microneedle is damaged due to premature manipulation of the user.

As another conventional technique, the inventor of the present invention refers to a technology filed by Korean Patent Application No. 10-2016-0118309 and registered as Korean Patent No. 10-1746048. The name of the invention is " micro needle patch applicator ". In this prior art, a micro needle patch applicator as shown in Fig. 2 is proposed.

The microneedle patch applicator 20 includes a main body 21, a band 30 attached to the main body 21 to connect the main body 21 to a user's body, (22) and a cylinder (23) for pushing the micro needle patch (10) inserted in the slot (22) downward. The microneedle patch 10 is inserted into the slot 22 while being attached to the insertion support 11 and is released from engagement with the insertion support 11 when it is pressed downward by the cylinder 23, Lt; / RTI > The pressurized state is maintained until there is a separate release operation.

In the case of the microneedle patch applicator of FIG. 2, the problems that may occur in the process of mounting the microneedle patch of the prior art described in FIG. 1 to the applicator are improved. 2, since the micro needle patch is inserted into the slot 22 of the applicator while being attached to the insertion support body 11, the possibility of contamination of the micro needle is reduced in the process of applying the micro needle patch to the applicator.

However, the prior art of Fig. 2 does not fundamentally eliminate the possibility of micro-needle contamination. There is a possibility of contamination or damage due to mis-collimation of the user in the process of inserting the micro needle patch into the slot 22. [ The user can grasp the inserted support 11 and relatively easily insert it into the slot 22 of the applicator (as compared to the prior art of FIG. 1), but if inserted incorrectly into the small, narrow slot 22, have. In the insertion process, the exposed micro needle may be touched by the user's hand or other object, thereby causing contamination or damage. Also, the sheet 12 of the microneedle patch is always exposed through the lower opening of the applicator until the microneedle patch is inserted into the applicator in an insertion manner and applied to the skin. It is not possible to exclude the possibility that the pollutant is adhered to the micro needle patch sheet 12 through the opening portion.

Disclosure of Invention Technical Problem [8] The present invention has been made to solve the problems of the prior art described above, and it is an object of the present invention to provide a micro needle dispenser which can prevent contamination and damage of a micro needle in a process of attaching a micro needle patch to an applicator, And a microneedle patch applicator system composed of such a microneedle patch and an applicator.

In order to accomplish the above object, a representative structure of the present invention is as follows.

The micro needle patch 10 according to the present invention comprises a sheet 12 formed with a micro needle 11 at a lower portion thereof and having a tacky material formed around at least a portion where the micro needle 11 is formed; A pressure sensitive adhesive (13) formed on the sheet (12); A protective film (15) for protecting the pressure sensitive adhesive (13) formed on the sheet (12); And a needle protection cap attached to the lower portion of the seat 12 to protect the micro needle 11.

Further, the outer periphery of the sheet 12 can be configured to be connected to the slot supporting portion 16 via the easy-to-break portion.

The needle protection cap 14 is formed so that the central portion thereof is convex downwardly, the micro needle 11 is accommodated in the central space thereof, and the flat portion for contacting the lower surface of the seat 12 is formed .

The microneedle patch applicator system according to the present invention comprises a microneedle patch 10 having the structure as described above and a microneedle patch applicator 20 for applying the microneedle patch 10 to the user's skin. Here, the microneedle patch applicator 20 includes a bar 30 accommodated in the main body 21 and movable up and down; And an insertion port into which the micro needle patch 10 formed in the main body 21 is inserted. The microneedle patch 10 is inserted into the insertion port and placed in a downwardly pressable state by the bar 30. The insertion port is a structure in which the micro needle patch 10 can be inserted while the needle protection cap 14 is mounted. The needle protection cap 14 is removed before the bar 30 presses the micro needle patch 10 downward.

The lower end of the bar 30 can contact the pressure sensitive adhesive 13 exposed on the upper surface of the sheet 12 of the microneedle patch 10.

A slot may be formed in the side surface of the main body 21 as an insertion port and the micro needle patch 10 may be inserted into the main body 21 through the slot.

Additional configurations may further be included in the microneedle patch and microneedle patch applicator system according to the present invention.

According to the present invention, the problems of the above-described conventional techniques can be solved. More particularly, the present invention relates to a micro needle patch capable of preventing contamination and damage of the micro needle in the process of mounting the micro needle patch to the applicator and before the micro needle patch is applied to the skin after being attached to the applicator, A micro needle patch applicator system comprising an applicator can be provided.

1 is a diagram showing a prior art micro needle patch applicator.

2 is a diagram of another prior art micro needle patch applicator.

3 is a view showing a micro needle patch according to an embodiment of the present invention.

4 is a view showing an applicator of a microneedle patch according to an embodiment of the present invention.

5 is a view showing a micro needle patch according to another embodiment of the present invention.

FIG. 6 is a cross-sectional view of a microneedle patch according to the embodiment of FIG. 5 mounted on an applicator through a slot formed in a side surface of the applicator.

7 is a view for explaining a method of using a microneedle patch applicator system according to an embodiment of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings, so that those skilled in the art can easily carry out the present invention.

In order to clearly illustrate the present invention, parts that are not related to the present invention are omitted, and the same components are denoted by the same reference numerals throughout the specification. In addition, since the sizes and the like of the respective components shown in the drawings are arbitrarily shown for convenience of explanation, the present invention is not necessarily limited thereto.

That is, the specific shapes, structures, and characteristics described in the specification can be implemented by changing from one embodiment to another embodiment without departing from the spirit and scope of the present invention. It is to be understood that changes may be made without departing from the scope. Therefore, the following detailed description is not to be taken in a limiting sense, and the scope of the present invention should be construed as encompassing the scope of the appended claims and all equivalents thereof.

3 is a perspective view of a microneedle patch 10 according to an embodiment of the present invention.

The micro needle 11 is disposed at the center of the lower portion of the sheet 12. A pressure sensitive adhesive for fixation of the sheet 12 when the sheet 12 is applied may be applied to a portion of the lower portion of the sheet 12 other than the central portion where the micro needle 11 is disposed.

The pressure-sensitive adhesive is composed of a pressure-sensitive pressure-sensitive adhesive which can be used medicinally, and aqueous or organic solvent materials can be used. Examples of the adhesive polymer material include acrylic resins such as acrylate polymers and vinyl acetate-acrylate copolymers, polyisobutylene, polystyrene copolymers, natural or synthetic rubbers, or mixtures thereof. The adhesive polymer may be used alone or in combination of two or more.

Also, the adhesive 13 may be applied to the upper surface of the sheet 12 as well. The adhesive 13 formed on the upper surface of the sheet 12 of the microneedle patch 10 may be temporarily bonded to the lower end of the bar 30 of the applicator 20 to press the microneedle patch 10 against the user's skin .

This adhesive 13 allows the bar 30 to accurately apply downward pressure to the micro needle patch 10 and unnecessary movement of the micro needle patch 10 when the bar 30 is moved downward . When the bar 30 is lowered by applying the pressure-sensitive adhesive 13, the microneedle patch 10 can be accurately positioned at a desired position when applying the user's skin while maintaining the connection with the bar 30.

A protective film 15 for protecting the sheet 12 upper surface adhesive 13 can be applied. The protective film 15 must be removed before the microneedle patch 10 is inserted into the applicator 20. The protective film 15 may extend to a position where a part of the protective film 15 is out of the outer boundary of the micro needle patch 10. [

The extension of this protective film 15 helps the user to easily remove the micro needle patch 10 before inserting it into the applicator 20.

One of the most characteristic features of the present invention is that the needle protection cap 14 is mounted below the seat 12 in order to protect the lower adhesive side of the micro needle 11 and the seat 12 from external contaminants and damage to be.

The needle protection cap 14 must be removed before the micro needle patch 10 is pressed against the user's skin. Without the removal of the needle protection cap 14, it is impossible for the micro needle patch 10 to be applied to the user's skin.

The needle protection cap 14 is inserted into the applicator until the micro needle 11 is bent or broken until the micro needle patch 10 is inserted into the applicator, .

The micro needle patch 10 can be stably protected for a desired period of time unless the needle protection cap 14 is removed even if the micro needle patch 10 is not immediately applied to the skin after inserting it into the applicator.

The outer periphery of the needle protection cap 14 may be provided so as to coincide with the outer periphery of the sheet 12 so as to cover the micro needle 11 and the adhesive surface of the lower portion of the sheet 12. [

The needle protection cap 14 may have a shape for adhering to the lower surface of the sheet 12. The adhesive surface area of the needle protection cap 14 with the sheet 12 is such that the needle protection cap 14 does not inadvertently disengage from the seat 12, Is selected such that it does not affect the seating condition within the applicator 20 of the sheet 12 upon attempted departure.

Although not shown in Fig. 3, a knob can be applied to the outer surface of the needle protection cap 14. Fig. This handle is advantageous for enhancing the convenience of the user by providing a suitable grip when the micro needle patch 10 is attached to the applicator and the needle protection cap 14 is removed before application of the skin.

The handle can be provided with a soft material such as silicone, and its shape is not limited. For example, the grip may be provided in the form of a non-slip groove so as not to slip when gripped by hand.

4 shows an embodiment of a microneedle patch applicator 20 according to the present invention in which the needle protection cap 14 is applied to the microneedle patch 10 with reference to FIG. Will be described.

4, a hole is provided in the lower portion of the applicator 20 so that the bar 30 is exposed to the outside. Thus, the micro needle patch 10 to which the needle protection cap 14 is applied can be mounted through the lower hole formed in the main body 21 of the applicator 20.

After the needle protection cap 14 is applied to the micro needle patch 10 and the knob which can be formed on the needle protection cap 14 is gripped and inserted from below to the top, attachment by the adhesive force of the adhesive 13 to the bar 30 .

The lower portion of the main body 21 is always open as shown in FIG. 4, so that the needle can be inserted from the bottom up with the needle protection cap 14 applied to the micro needle patch 10. This insertion is completed by the adhesive 13 formed on the upper surface of the sheet 12 of the microneedle patch 10 contacting the lower end of the bar 30 to form a tacky bond with each other.

Even when the micro needle patch 10 is inserted into the applicator 20, the needle protection cap 14 of the micro needle patch 10 can be maintained as it is. The microneedle patch 10 inserted into the applicator 20 can be protected and the microneedle patch 10 is inserted into the applicator 20, that is, Can be stored for a long time without being contaminated or damaged. Of course, the needle protection cap 14 has to be removed just prior to applying the micro needle patch 10 to the user's skin.

Removal of the needle protective cap 14 may be accomplished by pulling the needle protection cap 14 exposed downward by the open lower hole. In this case, the seat 12 should remain engaged with the lower end of the bar 30 even if the needle protection cap 14 is pulled down and the needle protection cap 14 is disengaged from the seat 12. To this end, the adhesive force between the lower end of the bar 30 and the upper surface of the sheet 12 must be sufficiently greater than the adhesive force between the lower portion of the seat 12 and the needle protective cap 14.

When the bar 30 is pressed downward with the microneedle patch 10 inserted into the applicator 20 and the needle protection cap 14 removed, the sheet 12 of the microneedle patch 10 is pressed against the user's skin As shown in FIG. When the bar 30 is lowered due to the operation of the applicator 20 and the microneedle patch 10 is placed on the skin of the user and then rises again, the lower end of the bar 30 and the microneedle patch 10 Should be easily released. The binding force between the lower end of the bar 30 and the adhesive 13 applied to the upper surface of the sheet 12 is greater than the binding force between the skin of the user and the adhesive 13 applied to the lower surface of the sheet 12, Is preferably selected to be sufficiently smaller than the sum of the binding force of the skin with the micro needle 11 when the skin 11 penetrates the skin.

5 is a view showing a micro needle patch 10 according to another embodiment of the present invention. In the microneedle patch 10 according to the embodiment of FIG. 5, the sheet 12 is easily detachably coupled to a slot supporting portion 16 that can be inserted and supported in a slot of the applicator 20. That is, when the micro needle patch 10 of the type shown in FIG. 5 is used, a slot on the side surface of the main body 21 is necessarily formed. For the concept of slots, reference is made to slot 22 in Fig. 2, which is a drawing of the prior art. 5, since the needle protection cap 14 is inserted together when the micro needle patch 10 is inserted into the slot formed on the side surface of the main body 21, the shape of the slot is also the same as that of the needle protection cap 14 Must be formed so that the micro needle patch 10 can be inserted.

The coupling portion is shown by the dotted line in Fig. This coupling portion is easily broken when the bar 30 is moved downward so that the sheet 12 and the micro needle patch 10 attached thereto are pressed toward the user's skin and the slot supporting portion 16 is directly fed to the applicator 20 ) And then removed from the slot. The micro needle patch 10 of the embodiment shown in Fig. 5 also includes the needle protection cap 14 as in the embodiment shown in Fig. 3, and the pressure sensitive adhesive 13 and the pressure sensitive adhesive 13 on the upper surface of the sheet 12 And a protection film 15 for protection.

Fig. 6 is a cross-sectional view of the microneedle patch 10 according to the embodiment of Fig. 5 mounted on the applicator 20. Fig. In the embodiment shown in FIG. 6, the bar 30 accommodated in the main body 21 of the applicator 20 is formed integrally with the button portion 31 formed on the upper portion thereof.

A spring 40 may be positioned between the button portion 31 of the bar 30 and the inner structure of the body 21 of the applicator 20. As will be described later, such a spring 40 is not an essential component of the present invention.

When the button portion 31 of the bar 30 is pressed, the bar 30 can be lowered to the maximum compression position of the spring 40. When the hand is released in this state, the bar 30 can return to its original position. According to the applicator 20, after the bar 30 presses the microneedle patch 10 applied to the applicator 20 downward toward the user's skin and the microneedle patch 10 is seated on the skin of the user, May not perform an immediate return to its original position.

In this type of applicator 20, the bar 30 is fixed in a downward position for a predetermined period of time and then returns to its original position by pressing a button or performing other operations. The bar 30 maintains the pressure on the user's skin of the microneedle patch 10 for a period of time during which the bar 30 is moved downward. This type of applicator 20 is particularly advantageous when the microneedle patch 10 comprises a microneedle 11 formed of an active ingredient for medical purposes and this active ingredient needs to be absorbed by the user's skin for the correct time, It can be useful.

The elevation of the bar 30 may be realized by a trigger structure that operates when the bar 30 maintains the falling state for a predetermined length of time and the timer indicates the passage of time.

In the applicator 20 which implements the downward pressure holding function by the bar 30, it is preferable to use a band 50 for fixing the main body of the applicator 20 to the user's body. An embodiment of an applicator 20 using a band 50 is shown in Fig.

According to the embodiment of Figure 6, a band 50 is connected to the side of the body 21 of the applicator 20. The band 50 is provided for fixing the applicator 20 to the user's body, and the length of the band 50 can be adjusted according to the position of the user's body. The length of the band 50 can be adjusted relatively short if the applicator 20 is applied to the user's arm and the length of the band 50 is adjusted relatively long if the applicator 20 is applied to the abdominal region of the user .

6 for holding the compressed state of the spring 40 in the main body 21 of the applicator 20 shown in Fig. 6 in order to maintain downward pressure by the bar 30 for a predetermined time, And a button for releasing the jam or an alternative technical means for performing the same function can be further applied, and these technical means are well known to those skilled in the art. Further, technical means capable of performing the action of raising the bar 30 when the downward pressing and the downward pressing by the bar 30 are not performed for a certain period of time or when the downward pressing is unnecessary without using the spring 40 is performed by the applicator 20, It is possible to apply it to any of them.

The mouth of the slot may be located on the side of the body 21 of the applicator 20 where the band is not connected and the micro needle patch 10 to which the needle protection cap 14 is applied is inserted through the slot . The protective film 15 on the adhesive 13 on the upper surface of the sheet 12 is removed in the inserted state to form a bond between the adhesive 13 of the sheet 12 and the lower end of the bar 30. [

7, the steps of using the microneedle patch applicator 20 according to an embodiment of the present invention are shown in order, assuming that the microneedle patch 10 as shown in the embodiment of FIG. 3 is used.

In the first step, the micro needle patch 10 is prepared. The micro needle patch 10 has the structure and function as described above.

In the second step, the protective film 15 is removed from the micro needle patch 10. The protective film 15 protects the adhesive 13 formed on the upper surface of the sheet 12 of the microneedle patch 10, that is, the surface opposite to the surface on which the microneedles 11 are disposed, 10 can be easily removed using the extension just before being applied to the microneedle patch applicator 20.

In the third step, the protective film 15 is removed and the micro needle patches 10, on which the adhesive 13 on the upper surface of the sheet 12 is exposed, are removed from the micro needle patch applicator 20 with the needle protection cap 14 applied. The lower end of the applicator bar 30 and the exposed adhesive 13 of the microneedle patch 10 may form a bond. At this stage, the needle protection cap 14 is gripped by the user's hand, and the grip portion described above can be applied to assist gripping.

In the fourth step, the needle protection cap 14 is removed. The function of the needle protection cap 14 is to prevent contamination or damage of the micro needle 11 and the adhesive surface of the sheet 12 to be applied to the skin until the micro needle patch 10 is applied to the user's skin, The protective cap 14 is preferably held until the user applies it to the skin.

Even if the microneedle patch 10 is not applied to the skin immediately after inserting the microneedle patch 10 into the applicator 20, if the needle protecting cap 14 is not removed, the microneedle patch 10 is kept for a long time It is possible.

In a fifth step, the user actuates the applicator 20 so that the bar 30 of the microneedle patch applicator 20 is lowered. 6, a mechanism in which the bar 30 integrally formed with the button portion 31 is lowered by the user pressing the button portion 31 downward has been described. However, the scope of the present invention is limited to such a mechanism It should not be interpreted. It should be understood that the present invention encompasses any mechanism that allows downward pushing of the micro needle patch 10 inserted in the applicator 20 by the bar 30 into the scope of the invention. As the bar 30 is pressed downward, the micro needle patches 10 are lowered and attached to the user's skin. The contact between the bar 30 and the microneedle patch 10 can be maintained satisfactorily due to the adhesive 13 on the upper surface of the sheet 12 of the microneedle patch 10. In this way, The contact of the micro needle patch 10 can be precisely formed at a desired position on the skin of the user without changing the posture or position of the micro needle patch 10.

In the sixth step, the bar 30 rises after the micro needle 11 of the micro needle patch 10 is well infiltrated into the user's skin. In the embodiment shown in Fig. 6, the upward movement of the bar 30 is explained by the restoring force of the spring 40, but the lift mechanism of the bar 30 is not limited thereto. It should be understood that the scope of the present invention encompasses any mechanism capable of returning the bar 30 to its original position immediately or after a certain time after the good attachment of the micro needle patch 10 to the user's skin.

Description of the Drawings:

10: Micro needle patch

11: Micro needle

12: Sheet

13: Adhesive

14: Needle protection cap

15: Protective film

16: Slot support

20: Micro needle patch applicator

21:

30: Bar

40: spring

50: Band

Claims

A sheet 12 in which a micro-needle 11 is formed at a lower portion and at least a portion where a micro-needle 11 is formed is formed with an adhesive,

A pressure sensitive adhesive (13) formed on the sheet (12)

A protective film 15 for protecting the pressure sensitive adhesive 13 formed on the sheet 12 and a needle protection cap attached to the lower portion of the sheet 12 to protect the micro needle 11, 10).
The microneedle patch (10) according to claim 1, wherein the outer periphery of the sheet (12) is connected to the slot supporting part (16) via an easy rupture part.
The needle protection cap according to claim 1 or 2, wherein the needle protection cap (14) is formed so as to be convex downward at its central portion, the microneedles (11) And a flat portion for contact with the surface is formed.
A microneedle patch applicator (20) comprising a microneedle patch (10) according to claim 1 or 2 and a microneedle patch applicator (20) for applying the microneedle patch (10)

A bar 30 accommodated in the main body 21 and movable up and down,

And an insertion port into which a micro needle patch (10) formed in the main body (21) is inserted,

The microneedle patch 10 is inserted into the insertion port and placed in a state of being downwardly pressable by the bar 30,

The insertion port has a structure in which the micro needle patch 10 can be inserted in a state where the needle protection cap 14 is mounted,

The needle protection cap 14 is removably secured to the bar 30 before the bar 30 is pressed downward against the micro needle patch 10. [

Micro needle patch applicator system.
5. The microneedle patch applicator system according to claim 4, wherein the lower end of the bar (30) contacts the pressure sensitive adhesive (13) exposed on the upper surface of the sheet (12) of the microneedle patch (10).
6. The microneedle patch applicator system according to claim 5, wherein a slot is formed in the side surface of the main body (21) as an insertion port, and a micro needle patch (10) is inserted into the main body (21) through the slot.