WO2019040022A2 - Immunotherapeutic cancer vaccine - Google Patents
Immunotherapeutic cancer vaccine Download PDFInfo
- Publication number
- WO2019040022A2 WO2019040022A2 PCT/TR2018/050154 TR2018050154W WO2019040022A2 WO 2019040022 A2 WO2019040022 A2 WO 2019040022A2 TR 2018050154 W TR2018050154 W TR 2018050154W WO 2019040022 A2 WO2019040022 A2 WO 2019040022A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cancer
- lactobacillus acidophilus
- vaccine
- strain
- strains
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0208—Specific bacteria not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1278—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Bacillus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/836—Intestine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
Definitions
- This invention is concerned with development of a vaccine from bacteriocin belong to 3 ⁇ 4 Lactobacillus acidophilus LA-S 2 strain known as lactic acid bacteria for use in the treatment of cancer, especially colon cancer.
- C olon cancer large bowel cancer
- colorectal cancer is cancerous growths seen in colon, rectum and appendix.
- Colon cancer is the third most frequent cancers in the western world and ranks second among cancers leading cause of death. This cancer mostly arises from
- 3 ⁇ 4 adenoma polyps occurring in the large intestine P olyps are tissue swelling seen in the cavities of digestive tract. Polyps are known benign tumours among the people but the adenoma polyps are tumours that cause cancer known as malignant tumours among the population. C olon cancer is treated with surgical methods: tumour forming cancer and an amount of healthy tissue around it is taken. According to the state of stage, chemotherapy
- chemotherapy means drug therapy, it is the term used for the treatment performed by using cancer drugs affecting cancer cells. Drugs used for its are also called "anti-cancer drugs ". It may not always be possible to provide the desired benefits of chemotherapy drugs. If cancer tumours can not be destroyed by treatment or it is delayed for treatment, cancer cells can spread throughout the body via blood vessels or lymph nodes. In this case the situation called metastasis (spread) would have occurred.
- the method called immunotherapy in cancer treatment is used as a treatment method which destroy cancer cells by strengthening the immune system of patient 3 ⁇ 4 when used in the early stages of cancer. Also, it is used as an adjuvant therapy to prevent recurrence of the disease after chemotherapy and surgical intervention.
- Immunotherapy is applied three different ways.
- the antibodies by the vaccine developed through molonoclonal antibody method is given to the patient and it is tried to treat by allowing the antibodies to fight with cancerous structures.
- the non-specific immunotherapy, on the other hands, is a treatment applied after chemotherapy or simultaneous with chemotherapy. It is seen some side effects.
- bacteriocins purified from producer bacteria cells had been determined with Tris- tricine S DS -PAG E method, which is a different form of sodium dodecyl sulfate polyacrylamide gel electrophoresis (S DS -PAG E ) and is applied to determine especially the proteins having the molecular weight between 1 -10 kDa, and also with Mass S pectrometry Analysis. Obtained bacteriocins had been characterized in terms of thermal resistance at different pH, pH sensitivity, stability and susceptibility to proteolythic, lipolythic and amylolithic enzymes.
- Lactobacillus acidophilus LA-S 2 strain and its bacteriocin given best results in terms of the properties such as viability, biological barrier resistance, adhesive effect, antimicrobial activity spectrum, etc ft, after the cell culture and bioprocess studies, had been selected to use in in vivo experiments.
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2017/06714 | 2017-05-08 | ||
TR2017/06714A TR201706714A2 (en) | 2017-05-08 | 2017-05-08 | IMMUNOTHERAPIC CANCER VACCINE |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2019040022A2 true WO2019040022A2 (en) | 2019-02-28 |
WO2019040022A3 WO2019040022A3 (en) | 2019-05-09 |
Family
ID=65439551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/TR2018/050154 WO2019040022A2 (en) | 2017-05-08 | 2018-04-09 | Immunotherapeutic cancer vaccine |
Country Status (2)
Country | Link |
---|---|
TR (1) | TR201706714A2 (en) |
WO (1) | WO2019040022A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023063918A1 (en) * | 2021-10-17 | 2023-04-20 | Essa Tekni̇k Ki̇mya İthalat İhracat Sanayi̇ Ve Ti̇caret Li̇mi̇ted Şi̇rketi̇ | Development and production of anticancer peptides of bacteriocin origin as biological and immunotherapeutic agents in cancer immunotherapy and as peptide antibiotics in infection immunotherapy |
WO2024010553A1 (en) * | 2022-07-02 | 2024-01-11 | Arslan Filiz | Immunotheraputic cancer vaccine |
-
2017
- 2017-05-08 TR TR2017/06714A patent/TR201706714A2/en unknown
-
2018
- 2018-04-09 WO PCT/TR2018/050154 patent/WO2019040022A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
TR201706714A2 (en) | 2017-09-21 |
WO2019040022A3 (en) | 2019-05-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Seo et al. | CD8+ T-cell density imaging with 64Cu-labeled cys-diabody informs immunotherapy protocols | |
BR112020004347A2 (en) | extracellular vesicles of prevotella | |
AU2013286335B2 (en) | DNA vaccine for use in pancreatic cancer patients | |
Zhi et al. | Oral pH sensitive GNS@ ab nanoprobes for targeted therapy of Helicobacter pylori without disturbance gut microbiome | |
Cany et al. | AFP-specific immunotherapy impairs growth of autochthonous hepatocellular carcinoma in mice | |
CN106572993A (en) | Combination therapies for the treatment of cancer | |
Mastrangelo et al. | Regression of pulmonary metastatic disease associated with intralesional BCG therapy of intracutaneous melanoma metastases | |
CN110462066A (en) | Nano vesicle and application thereof from greedy copper campylobacter bacteria | |
WO2019040022A2 (en) | Immunotherapeutic cancer vaccine | |
CN114452382A (en) | Application of bacteroides fragilis capsular polysaccharide A, PD-1 and PD-L1 antibodies in combined treatment of respiratory system tumors | |
CN114425080B (en) | Application of bacteroides fragilis and PD-1 or PD-L1 antibody combined medicament in treatment of genitourinary system cancer | |
Li et al. | Promising alternatives of CD47 monoclonal antibody: An injectable degradable hydrogel loaded with PQ912 for postoperative immunotherapy effectively blocks CD47-SIRPα signal | |
CN114469987A (en) | Application of bacteroides fragilis zwitter ion capsular polysaccharide and immune checkpoint inhibitor in combined drug treatment of genitourinary system tumor | |
Xu et al. | Targeted elimination of myeloid-derived suppressor cells via regulation of the STAT pathway alleviates tumor immunosuppression in neuroblastoma | |
CN113244273A (en) | Use of plasmodium in preparing anti-tumor preparation for combined radiotherapy | |
CN108178783A (en) | Tumor vessel and M1 type macrophage targeting peptides and application thereof | |
Lu et al. | Bifidobacterium animalis sup F1-7 Acts as an Effective Activator to Regulate Immune Response Via Casepase-3 and Bak of FAS/CD95 Pathway | |
US20110150934A1 (en) | Ovarian Tumor Tissue Cell Preparations/Vaccines for the Treatment/Inhibition of Ovarian Tumors and Ovarian Cancer | |
US11090357B2 (en) | Bioengineered lactobacillus probiotics and the uses thereof | |
WO2013188529A1 (en) | Use of isolated bacterial amyloids for treatment of inflammatory disorders or diseases of the epithelium | |
JP6616293B2 (en) | Immunogenic stress protein based therapeutic cancer vaccine | |
Whelan et al. | Oral tolerance to cancer can be abrogated by T regulatory cell inhibition | |
WO2024010553A1 (en) | Immunotheraputic cancer vaccine | |
TWI310686B (en) | ||
Zhou et al. | Low-dose docetaxel enhances the anti-tumour efficacy of a human umbilical vein endothelial cell vaccine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 18847870 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
32PN | Ep: public notification in the ep bulletin as address of the adressee cannot be established |
Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 12.03.2020) |
|
32PN | Ep: public notification in the ep bulletin as address of the adressee cannot be established |
Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 12.03.2020) |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 18847870 Country of ref document: EP Kind code of ref document: A2 |