WO2019037058A1 - Surface treatment process for trans-gingival portion of dental implant - Google Patents
Surface treatment process for trans-gingival portion of dental implant Download PDFInfo
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- WO2019037058A1 WO2019037058A1 PCT/CN2017/098921 CN2017098921W WO2019037058A1 WO 2019037058 A1 WO2019037058 A1 WO 2019037058A1 CN 2017098921 W CN2017098921 W CN 2017098921W WO 2019037058 A1 WO2019037058 A1 WO 2019037058A1
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- dental implant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
Definitions
- the invention relates to the technical field of a method for surface modification of a biomedical metal implant material.
- Oral implant systems typically include three parts: a body that is implanted in the alveolar bone with bone tissue, an artificial crown, and an oral implant abutment that connects between the body and the artificial crown.
- the surface roughness of the crotch portion of the existing oral implant abutment is the same as the surface roughness of the piercing portion.
- the sulcus and the perforation have different contact areas with the oral environment, and the sulcus and the sulcus should meet their functional requirements.
- the gingival fiber ring is tightly wrapped around the neck of the implant abutment, so the surface of the gingival part often has a certain degree of roughness, so as to facilitate the wrapping of the gingival cells and form a good soft tissue closure.
- the sulcus is directly exposed to the oral environment, and its surface roughness is the same as the surface roughness of the sulcus, so that the sulcus is easy to adhere to the plaque, and the incidence of inflammation around the implant is large.
- the invention provides a surface treatment process for the dental implant through the sputum, so that the micro-nano-graded structure is formed on the surface of the dental implant, the adhesion of the plaque at the sulcus at the surface roughness is reduced, and the inflammation around the implant is reduced. Probability; at the same time, it can also reduce the adhesion of soft tissue, form a natural sulcus, achieve better aesthetic effects, and better meet the functional requirements of the sulcus.
- a dental implant surface treatment process includes the following steps:
- the dental implant is implanted into the inner segment of the bone by conventional sandblasting-etching composite process.
- the abrasive is used in 40-80 mesh, the compressed air pressure is 4-8 bar, the spraying distance is 50-150 mm, and the spraying time is 2 ⁇ . 20 seconds
- the acid etching solution is prepared by mixing concentrated sulfuric acid, concentrated hydrochloric acid and deionized water with a volume ratio of 1 to 4:2 to 5:2 to 6, the etching temperature is 40-100 ° C, and the etching time is 5-25 min. ;
- the dental implants were sequentially ultrasonically washed in acetone, 75% ethanol and deionized water, and dried.
- the implanted bone inner segment of the dental implant is surface-treated by a sandblasting-etching process or micro-arc oxidation.
- step 3 is replaced by: 3') The piercing section of the dental implant after the blasting-etching treatment is subjected to electrochemical deposition or chemical deposition treatment.
- the roughness Ra of the surface of the dental implant through the crotch portion is 0.5 to 2 ⁇ m.
- the surface treatment method combining physical method and chemical method is applied to the field of oral implants, and the device is simple, convenient to operate, low in production cost, and suitable for industrial production.
- the dental implant surface is subjected to electrochemical anodization through the surface treatment of the dental implant surface to form a nanotube array on the surface.
- Structure further depositing nano-scale calcium phosphate-based substances (nano-needles, nanoparticles, etc.) in the nanotube array by electrochemical deposition surface treatment process, that is, "nanoparticle-mounted nanotube array composite structure".
- nano-scale calcium phosphate-based substances nano-needles, nanoparticles, etc.
- the tubular structure of the anodized nanotubes "filled” with nano-sized calcium phosphate can further induce the penetration of epithelial cells and fibroblast pseudopods and form tight interlocking interpenetration. Improve the firm binding of surrounding fibrous tissue or collagen fibers to the implant surface.
- the segmented surface microstructure design of the perforation prevents the descending of the epithelial tissue and improves the binding of the fibrous connective tissue to the implant, thereby enhancing the biological sealing of the implant through the sputum, reducing the adhesion of the plaque, and reducing the planting. The incidence of inflammation around the body.
- Figure 1 is a SEM picture of the dental implant sample after sandblasting-etching
- Figure 2 is a SEM picture of the dental implant sample after an anodizing treatment
- Figure 3 is a SEM image of a dental implant sample after electrochemical deposition of apatite particles.
- the reagents used in the present invention are all commercially available reagents.
- the measurement methods and the like used in the present invention are mostly conventional methods in the art, and will not be further described herein.
- the electrochemical surface treatment process is performed on the piercing place of the dental implant, and the dental implant is ultrasonically cleaned in acetone, 75% ethanol and deionized water, respectively, and then dried;
- the implanted bone inner segment of the dental implant is subjected to a sandblasting-etching process or a micro-arc oxidation process.
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- Oral & Maxillofacial Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
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Abstract
A surface treatment process for a trans-gingival portion of a dental implant, comprising the steps of: performing an electrochemical surface treatment process on a trans-gingival portion of a dental implant; treating the segment of the dental implant implanted in a bone by using a conventional sandblasting-acid etching composite process; and performing electrochemical anodic oxidation and electrochemical deposition on a trans-gingival segment of the dental implant subjected to the sandblasting-acid etching treatment. The construction method can apply a surface treatment method combining a physical method with a chemical method in the field of oral implants, and features simple equipment, ease of operation, low production costs, and applicability to industrial production. The method can further induce the penetration of epithelial cells and fibroblast pseudopods and form tight interlocking interpenetration, thereby improving the strength of binding of surrounding fibrous tissue or collagen fibers to the surface of the implant; surface microstructure design of the trans-gingival segment can avoid the descending of epithelial tissue and improve the binding of the fibrous connective tissue to the implant, thereby enhancing the biological sealing property of the trans-gingival portion of the implant, reducing the adhesion of plaque, and reducing the probability of occurrence of peri-implantitis.
Description
技术领域Technical field
本发明涉及一种生物医用金属植入材料表面改性的方法技术领域。The invention relates to the technical field of a method for surface modification of a biomedical metal implant material.
背景技术Background technique
口腔种植系统通常包括三部分：植入牙槽骨中与骨组织结合的体部、人工牙冠以及在体部与人工牙冠之间起连接作用的口腔种植体基台。Oral implant systems typically include three parts: a body that is implanted in the alveolar bone with bone tissue, an artificial crown, and an oral implant abutment that connects between the body and the artificial crown.
现有口腔种植体基台的龈沟部的表面粗糙度与穿龈部的表面粗糙度相同。在临床应用中，龈沟部和穿龈部与口腔环境有着不同的接触区域，龈沟部和穿龈部都应满足各自的功能要求。其中，牙龈纤维环形紧密缠绕种植体基台的颈部，故穿龈部表面常有一定的粗糙程度，以利于牙龈细胞的包绕、形成良好的软组织封闭。但龈沟部是直接暴露于口腔环境中的，其表面粗糙度与穿龈部的表面粗糙度相同，使得龈沟部易于菌斑粘附，种植体周围炎发生几率较大。The surface roughness of the crotch portion of the existing oral implant abutment is the same as the surface roughness of the piercing portion. In clinical applications, the sulcus and the perforation have different contact areas with the oral environment, and the sulcus and the sulcus should meet their functional requirements. Among them, the gingival fiber ring is tightly wrapped around the neck of the implant abutment, so the surface of the gingival part often has a certain degree of roughness, so as to facilitate the wrapping of the gingival cells and form a good soft tissue closure. However, the sulcus is directly exposed to the oral environment, and its surface roughness is the same as the surface roughness of the sulcus, so that the sulcus is easy to adhere to the plaque, and the incidence of inflammation around the implant is large.
发明内容Summary of the invention
本发明提供一种牙种植体穿龈处表面处理工艺，使牙种植体表面形成微米-纳米分级结构，减少表面粗糙度较小的龈沟部处菌斑的粘附，降低种植体周围炎发生几率；同时也可减少软组织的附着，形成天然龈沟，达到较好的美学效果，较好的满足了龈沟部的功能要求。The invention provides a surface treatment process for the dental implant through the sputum, so that the micro-nano-graded structure is formed on the surface of the dental implant, the adhesion of the plaque at the sulcus at the surface roughness is reduced, and the inflammation around the implant is reduced. Probability; at the same time, it can also reduce the adhesion of soft tissue, form a natural sulcus, achieve better aesthetic effects, and better meet the functional requirements of the sulcus.
一种牙种植体穿龈处表面处理工艺，包括以下步骤：A dental implant surface treatment process includes the following steps:
1）采用夹具物理遮蔽或涂层保护的加工方法，对牙种植体穿龈处进行电化学表面处理工艺； 1) using a processing method of physical shielding or coating protection of the fixture to perform an electrochemical surface treatment process on the piercing portion of the dental implant;
2）对牙种植体植入骨内段采用常规的喷砂-酸蚀复合工艺处理，采用40～80目的磨料，压缩空气压力为4～8bar，喷射距离为50～150mm，喷射时间为2～20秒，酸蚀液为体积比1～4:2～5:2～6的浓硫酸、浓盐酸和去离子水配制而成，酸蚀温度为40～100℃，酸蚀时间为5～25min；2) The dental implant is implanted into the inner segment of the bone by conventional sandblasting-etching composite process. The abrasive is used in 40-80 mesh, the compressed air pressure is 4-8 bar, the spraying distance is 50-150 mm, and the spraying time is 2~. 20 seconds, the acid etching solution is prepared by mixing concentrated sulfuric acid, concentrated hydrochloric acid and deionized water with a volume ratio of 1 to 4:2 to 5:2 to 6, the etching temperature is 40-100 ° C, and the etching time is 5-25 min. ;
3）将喷砂-酸蚀处理后的牙种植体的穿龈段置入阳极氧化池中，并加入0.1～0.8Wt%的氢氟酸电解液进行阳极氧化。阳极氧化过程中机械搅拌，通10～60V直流电于阴阳极之间10～50min，取出超声波清洗试样，烘干；3) Put the piercing section of the dental implant after the blasting-etching treatment into an anodizing bath, and add 0.1-0.8 Wt% hydrofluoric acid electrolyte for anodizing. Mechanical agitation during the anodization process, 10 to 60 V DC is applied between the anode and cathode for 10 to 50 minutes, and the ultrasonic cleaning sample is taken out and dried;
4）将牙种植体的穿龈段浸没于含有磷酸氢氨、硝酸钙体系电解液中，控制pH值在6.5～8.5，通直流电恒电压-1至1V进行电化学沉积，沉积过程中机械搅拌，电化学沉积时间1～5min。4) Immerse the piercing section of the dental implant in an electrolyte containing ammonia hydrogen phosphate and calcium nitrate system, control the pH value from 6.5 to 8.5, conduct electrochemical deposition through a direct current constant voltage of -1 to 1 V, and mechanically stir during the deposition process. The electrochemical deposition time is 1 to 5 min.
其中，每一步骤之后都将牙种植体依次置于丙酮、75%乙醇、去离子水中分别超声清洗，干燥。After each step, the dental implants were sequentially ultrasonically washed in acetone, 75% ethanol and deionized water, and dried.
进一步，所述牙种植体的植入骨内段采用喷砂-酸蚀工艺或微弧氧化的方式进行表面处理。Further, the implanted bone inner segment of the dental implant is surface-treated by a sandblasting-etching process or micro-arc oxidation.
另外，所述步骤3替换为：3’）将喷砂-酸蚀处理后的牙种植体的穿龈段采用电化学沉积或化学沉积处理。In addition, the step 3 is replaced by: 3') The piercing section of the dental implant after the blasting-etching treatment is subjected to electrochemical deposition or chemical deposition treatment.
进一步，所述牙种植体穿龈段表面的粗糙度Ra为0.5～2微米。Further, the roughness Ra of the surface of the dental implant through the crotch portion is 0.5 to 2 μm.
本发明公开的牙种植体穿龈处表面处理工艺具有如下有益效果：The surface treatment process of the dental implant through the present invention has the following beneficial effects:
（1）
将物理方法与化学方法结合的表面处理方法应用在口腔种植体领域，设备简单、操作方便、生产成本低和适用于工业生产。(1)
The surface treatment method combining physical method and chemical method is applied to the field of oral implants, and the device is simple, convenient to operate, low in production cost, and suitable for industrial production.
（2）
在传统牙种植体喷砂-酸蚀表面处理的基础上，通过对牙种植体表面进行分段表面处理技术，将牙种植体表穿龈段表面进行电化学阳极氧化，在表面形成纳米管阵列结构；进一步通过电化学沉积表面处理工艺，在纳米管阵列内沉积纳米级的磷酸钙系物质（纳米针、纳米颗粒等），即“纳米颗粒镶嵌纳米管阵列复合结构”。经纳米级磷酸钙“装填”的阳极氧化纳米管管状结构（与结缔组织胶原纤维的排列方向平行）能进一步的诱导上皮细胞和成纤维细胞伪足的伸入并形成紧密的联锁穿插，进而提高周围的纤维组织或胶原纤维的与种植体表面的牢固结合。(2)
On the basis of the traditional dental implant blasting-etching surface treatment, the dental implant surface is subjected to electrochemical anodization through the surface treatment of the dental implant surface to form a nanotube array on the surface. Structure; further depositing nano-scale calcium phosphate-based substances (nano-needles, nanoparticles, etc.) in the nanotube array by electrochemical deposition surface treatment process, that is, "nanoparticle-mounted nanotube array composite structure". The tubular structure of the anodized nanotubes "filled" with nano-sized calcium phosphate (parallel to the direction of the connective tissue collagen fibers) can further induce the penetration of epithelial cells and fibroblast pseudopods and form tight interlocking interpenetration. Improve the firm binding of surrounding fibrous tissue or collagen fibers to the implant surface.
（3）
穿龈处分段表面微结构设计可阻止上皮组织的下行和提高纤维结缔组织与植入体的结合性，进而增强植入体穿龈处的生物学密封性，减少菌斑的粘附，降低种植体周围炎发生几率。(3)
The segmented surface microstructure design of the perforation prevents the descending of the epithelial tissue and improves the binding of the fibrous connective tissue to the implant, thereby enhancing the biological sealing of the implant through the sputum, reducing the adhesion of the plaque, and reducing the planting. The incidence of inflammation around the body.
附图说明DRAWINGS
图1为牙种植体样件喷砂-酸蚀后的SEM图片；Figure 1 is a SEM picture of the dental implant sample after sandblasting-etching;
图2为牙种植体样件穿龈段阳极氧化处理后的SEM图片；Figure 2 is a SEM picture of the dental implant sample after an anodizing treatment;
图3为牙种植体样件经电化学沉积磷灰石颗粒后的SEM图片。Figure 3 is a SEM image of a dental implant sample after electrochemical deposition of apatite particles.
具体实施方式Detailed ways
为了更好的理解本发明，下面结合说明书附图和具体实施例对本发明做进一步说明。本发明中使用的试剂均为市售试剂。本发明中使用的测定方法等多为本领域的常规方法，在此不再一一赘述。For a better understanding of the invention, the invention will be further described in conjunction with the drawings and specific embodiments. The reagents used in the present invention are all commercially available reagents. The measurement methods and the like used in the present invention are mostly conventional methods in the art, and will not be further described herein.
实施例1：Example 1:
1）采用夹具物理遮蔽或涂层保护的加工方法，对牙种植体穿龈处进行电化学表面处理工艺，牙种植体依次置于丙酮、75%乙醇、去离子水中分别超声清洗，然后干燥；
1) Using the processing method of physical shielding or coating protection of the fixture, the electrochemical surface treatment process is performed on the piercing place of the dental implant, and the dental implant is ultrasonically cleaned in acetone, 75% ethanol and deionized water, respectively, and then dried;
2）喷砂-酸蚀处理，采用40～80目的磨料（氧化锆、白刚玉、二氧化钛等）牙种植体样件骨植入段进行表面喷砂处理；喷砂处理的工艺条件，压缩空气压力为2～6bar，喷射距离为20～100mm，喷射时间为5～60秒；酸蚀液为体积比1～4:2～5:2～6的浓硫酸、浓盐酸和去离子水配制而成，酸蚀温度为40～100℃，酸蚀时间为5～25min；将样件依次置于丙酮、75%乙醇、去离子水中分别超声清洗10min，干燥；2) Sand blasting-etching treatment, using 40-80 mesh abrasive (zirconia, white corundum, titanium dioxide, etc.) dental implant sample bone blasting surface for surface blasting; blasting process conditions, compressed air pressure It is 2~6bar, the spraying distance is 20~100mm, the spraying time is 5~60 seconds; the acid etching solution is prepared by concentrated sulfuric acid, concentrated hydrochloric acid and deionized water with a volume ratio of 1-4:2~5:2~6. The etching temperature is 40-100 ° C, and the etching time is 5-25 min; the sample is sequentially ultrasonically cleaned in acetone, 75% ethanol and deionized water for 10 min, and dried;
3）将喷砂-酸蚀处理后的牙种植体的穿龈段置入阳极氧化池中，并加入0.1～0.8Wt%的氢氟酸电解液，阳极氧化过程中机械搅拌，通10～60V直流电于阴阳极之间10～50min，取出牙种植体依次置于丙酮、75%乙醇、去离子水中分别超声清洗，然后干燥；3) Put the piercing section of the dental implant after sandblasting-etching treatment into the anodizing tank, and add 0.1-0.8Wt% hydrofluoric acid electrolyte, mechanically stir during anodizing, pass 10~60V The direct current is between 10 and 50 minutes between the anode and the cathode, and the dental implant is taken out in acetone, 75% ethanol and deionized water, respectively, and then ultrasonically cleaned, and then dried;
4）将牙种植体的穿龈段浸没于含有磷酸氢氨、硝酸钙体系电解液中，控制pH值在6.5～8.5，通直流电恒电压-1至1V，电化学沉积过程中机械搅拌，电化学沉积时间1～5min，使牙种植体穿龈段表面的粗糙度Ra为0.5～2微米，随后将牙种植体依次置于丙酮、75%乙醇、去离子水中分别超声清洗，然后干燥；4) Immerse the piercing section of the dental implant in an electrolyte containing ammonia hydrogen phosphate and calcium nitrate system, control the pH value from 6.5 to 8.5, pass the direct current constant voltage -1 to 1V, mechanically stir during the electrochemical deposition process, and electricity The chemical deposition time is 1-5 min, so that the roughness Ra of the surface of the dental implant through the iliac crest is 0.5-2 μm, and then the dental implants are sequentially ultrasonically washed in acetone, 75% ethanol and deionized water, and then dried;
5）所述牙种植体的植入骨内段采用喷砂-酸蚀工艺或微弧氧化处理。5) The implanted bone inner segment of the dental implant is subjected to a sandblasting-etching process or a micro-arc oxidation process.
以上对本发明的较佳实施方式进行了具体说明，但本发明创造并不限于所述实施例，熟悉本领域的技术人员在不违背本发明精神的前提下还可作出种种的等同变型或替换，这些等同的变型或替换均包含在本申请权利要求所限定的范围内。The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the embodiments, and various equivalent modifications or substitutions can be made by those skilled in the art without departing from the spirit of the invention. These equivalent variations or alternatives are intended to be included within the scope of the claims.
Claims (5)
- 一种牙种植体穿龈处表面处理工艺，其特征在于包括以下步骤： A dental implant surface treatment process characterized by comprising the following steps:1）采用夹具物理遮蔽或涂层保护的加工方法，对牙种植体穿龈处进行电化学表面处理工艺； 1) using a processing method of physical shielding or coating protection of the fixture to perform an electrochemical surface treatment process on the piercing portion of the dental implant;2）对牙种植体植入骨内段采用常规的喷砂-酸蚀复合工艺处理，采用40～80目的磨料，压缩空气压力为4～8bar，喷射距离为50～150mm，喷射时间为2～20秒，酸蚀液为体积比1～4:2～5:2～6的浓硫酸、浓盐酸和去离子水配制而成，酸蚀温度为40～100℃，酸蚀时间为5～25min；2) The dental implant is implanted into the inner segment of the bone by conventional sandblasting-etching composite process. The abrasive is used in 40-80 mesh, the compressed air pressure is 4-8 bar, the spraying distance is 50-150 mm, and the spraying time is 2~. 20 seconds, the acid etching solution is prepared by mixing concentrated sulfuric acid, concentrated hydrochloric acid and deionized water with a volume ratio of 1 to 4:2 to 5:2 to 6, the etching temperature is 40-100 ° C, and the etching time is 5-25 min. ;3）将喷砂-酸蚀处理后的牙种植体的穿龈段置入阳极氧化池中，并加入0.1～0.8Wt%的氢氟酸电解液进行阳极氧化，阳极氧化过程中机械搅拌，通10～60V直流电于阴阳极之间10～50min，取出超声波清洗试样，烘干；3) Put the piercing section of the dental implant after the blasting-etching treatment into the anodizing bath, and add 0.1-0.8 Wt% hydrofluoric acid electrolyte for anodizing, mechanical stirring during the anodizing process, 10 ~ 60V DC between 10 ~ 50min between the anode and cathode, take out the ultrasonic cleaning sample, and dry;4）将牙种植体的穿龈段浸没于含有磷酸盐和无机钙盐溶液的电解液中，控制pH值在6.5～8.5，通直流电恒电压-1至1V范围进行电化学沉积，电化学沉积过程中机械搅拌，电化学沉积时间1～5min。 4) Immerse the piercing section of the dental implant in an electrolyte containing a solution of phosphate and inorganic calcium salt, control the pH value from 6.5 to 8.5, conduct electrochemical deposition through a direct current constant voltage of -1 to 1 V, and electrochemically deposit Mechanical agitation during the process, electrochemical deposition time of 1 to 5 min.
- 根据权利要求1所述的牙种植体穿龈处表面处理工艺，其特征在于：每一步骤之后都将牙种植体依次置于丙酮、75%乙醇、去离子水中分别超声清洗，干燥。The surface treatment process for dental implants according to claim 1, characterized in that after each step, the dental implants are sequentially ultrasonically cleaned and dried in acetone, 75% ethanol and deionized water.
- 根据权利要求1所述的牙种植体穿龈处表面处理工艺，其特征在于：所述牙种植体的植入骨内段采用喷砂-酸蚀工艺或微弧氧化的方式进行表面处理。The surface treatment process for a dental implant through the dentition according to claim 1, wherein the implanted bone inner portion of the dental implant is surface-treated by a sandblasting-etching process or micro-arc oxidation.
- 根据权利要求1所述的牙种植体穿龈处表面处理工艺，其特征在于，所述步骤3替换为：3’）将喷砂-酸蚀处理后的牙种植体的穿龈段采用电化学沉积或化学沉积处理。The dental implant penetrating surface treatment process according to claim 1, wherein the step 3 is replaced by: 3') electrochemically passing the piercing section of the dental implant after the sandblasting-etching treatment Deposition or chemical deposition treatment.
- 根据权利要求1或4所述的牙种植体穿龈处表面处理工艺，其特征在于：所述牙种植体穿龈段表面的粗糙度Ra为0.5～2微米。The surface treatment process for a dental implant through the skin according to claim 1 or 4, wherein the surface roughness of the surface of the dental implant through the crotch portion is 0.5 to 2 μm.
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| PCT/CN2017/098921 WO2019037058A1 (en) | 2017-08-25 | 2017-08-25 | Surface treatment process for trans-gingival portion of dental implant |
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| PCT/CN2017/098921 WO2019037058A1 (en) | 2017-08-25 | 2017-08-25 | Surface treatment process for trans-gingival portion of dental implant |
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