WO2019035227A1

WO2019035227A1 - Gel-type cosmetic composition

Info

Publication number: WO2019035227A1
Application number: PCT/JP2018/006791
Authority: WO
Inventors: 瞬小林; 貴大鈴木; 雅哉金子
Original assignee: 味の素株式会社
Priority date: 2017-08-17
Filing date: 2018-02-23
Publication date: 2019-02-21

Abstract

The present invention provides a product using a thickener, which can be used instead of an anionic polymer and which has an excellent feeling of use. More specifically, the present invention provides a gel-type cosmetic composition comprising 2.0 wt% or more of a guanylic acid in a water-soluble medium and having a pH of 4.0-7.0.

Description

Gel-like cosmetic composition

The present invention relates to a gel cosmetic composition.

Thickeners are used in a wide variety of products, such as various industrial products and food products.

For example, in cosmetics, thickeners are used to enhance usability and stability and to prevent dripping. For example, an anionic water-soluble polymer such as carboxyvinyl polymer is very inexpensive, highly thick, has a small amount of gelation in addition to gelation in a small amount, is excellent in transparency, has a good feeling of use with little stickiness Since it exists, it is widely used for base thickening of a wide range of compositions such as skin care and hair care. However, since the thickening mechanism of the anionic water-soluble polymer is due to neutralization of the carboxyl group, the presence of an electrolyte such as a metal salt significantly reduces the viscosity due to the salting-out effect, making it difficult to obtain the desired viscosity (Non-Patent Document 1, Patent Document 1). When an anionic water-soluble polymer is blended in a large amount to compensate for such a decrease in viscosity, stickiness, nulliness and stickiness occur during coating, resulting in an essential drawback that the feeling in use is impaired (Patent Document 1) 2).

On the other hand, conventionally, various water-soluble active ingredients have been proposed for skin care and hair care cosmetics, and many of them are composed of electrolytes. For example, water-soluble active ingredients such as an amino acid which is a component of a natural moisturizing factor, sodium pyrrolidone carboxylate which is an amino acid derivative, lactic acid, a polyamino acid and the like have excellent water retention function and can moisturize the skin. In addition, ascorbic acid and its derivatives, and water-soluble active ingredients such as tranexamic acid are blended in many cosmetics as a skin-whitening ingredient.

Therefore, it is desirable to develop a thickener which can be used in place of an anionic polymer and which can improve the feeling of use of a cosmetic regardless of the presence of an electrolyte.

By the way, it has been reported that adenosine 5'-phosphate, which is a kind of nucleotide, can be used as an active ingredient (for example, a blood circulation promoting agent, a hair restorer) in cosmetics (Patent Documents 3 and 4). In addition, a whitening agent containing guanine has been reported (Patent Document 5). Furthermore, it has been reported that nucleotides can be used as thickeners (Non-patent Document 2).

JP-A-8-99855 JP, 2005-120056, A Patent No. 3798927 gazette Patent No. 3957690 Patent No. 583 7 497

An object of the present invention is to develop a product using a thickener which can be used instead of an anionic polymer and which is excellent in the feeling in use.

As a result of intensive investigations, the present inventors have found that a predetermined composition containing a high concentration of guanylate has desired viscosity characteristics, and moreover, when applied to a body surface such as skin, the feeling of use is excellent. Therefore, the composition is a favorite which is frequently used on a daily basis among various applications in a wide range of fields such as various industrial products and foods, and a cosmetic which has a high need for feeling in use Are considered particularly suitable for use as

Guanylate is considered to be a highly safe component for subjects such as humans, because it is a umami component that is consumed on a daily basis. Therefore, also from the viewpoint of safety, guanylate is suitable for use as a cosmetic.

As long as the present inventors understand, using guanilic acid for adjusting physical properties of cosmetics or improving the feeling of use, in particular, as a thickener capable of improving the feeling of using cosmetics regardless of the presence of an electrolyte It is not known to use guanylate.

That is, the present invention is as follows.
[1] containing 2.0% by weight or more of guanylate in a water-soluble medium,
Gel cosmetic composition having a pH of 4.0 to 7.0.
[2] The gel cosmetic composition of the above-mentioned [1], which further comprises a cationic substance.
[3] The gel cosmetic composition according to the above [1] or [2], wherein the cationic substance is a metal ion.
[4] The gel cosmetic composition according to any one of the above [1] to [3], wherein the concentration of guanylate is 2.0 to 4.0% by weight.
[5] The gel cosmetic composition according to any one of the above [1] to [4], which has a pH of 4.5 to 6.5.
[6] The gel cosmetic composition according to any one of the above [1] to [5], which further contains inosinic acid.
[7] The gel cosmetic composition of the above-mentioned [6], wherein the concentration of inosinic acid is 0.1% by weight or more.
[8] The gel cosmetic composition according to any one of the above [1] to [7], which further comprises a water-soluble active ingredient.
[9] The gel cosmetic composition according to any one of the above [1] to [8], further comprising a polyol.
[10] The gel-like cosmetic composition is (i) completely free of RNA macromolecules and / or RNA constituents other than guanylate, or (ii) RNA constituents other than guanylate The gel cosmetic composition according to any one of the above [1] to [9], which is not contained in the same amount as guanyl acid.
[11] The gel cosmetic composition according to any one of the above [1] to [10], wherein the gel cosmetic composition is a defined composition.
[12] The gel cosmetic composition according to any one of the above [1] to [11], wherein the gel cosmetic composition is a moisturizing agent.

The cosmetic composition of the present invention containing guanyl acid at a high concentration can exhibit the effects of having desired viscosity characteristics and being excellent in feeling in use.
Since guanylate is considered to be a highly safe component to subjects such as humans, it can be said that the cosmetic composition of the present invention is also excellent in terms of safety.

The present invention comprises greater than 2.0% by weight of guanylate in an aqueous medium. A gel cosmetic composition (hereinafter simply referred to as “composition”) having a pH of 4.0 to 7.0 is provided.

The composition of the present invention depends on various conditions such as the type and concentration of other components (eg, physiologically acceptable salt, water-soluble medium, water-soluble active ingredient, polyol) contained in the composition of the present invention. It also varies, but contains more than 2.0% by weight of guanylate in a water-soluble medium. By having a pH of 4.0 to 7.0, sufficient gelling of the aqueous medium can be achieved. 8. The composition of the present invention has a higher concentration (e.g., 4.0% by weight or more, 5.0% by weight or more, and 8.) from the viewpoint of achieving higher viscosity gelation and / or improving the feeling in use, etc. Guanylic acid can be included at 0 wt% or more, 10 wt% or more).

The composition of the present invention is also, for example, 50% by weight or less, preferably 30% by weight or less, more preferably 25% by weight or less, still more preferably 20% by weight or less, from the viewpoint of cost reduction due to reduction of use amount. It may contain guanylate, particularly preferably at a concentration of up to 15% by weight.

Alternatively, the concentration of guanylate may be determined focusing on a specific feeling of use. For example, when focusing on the thickness at the time of application and / or the non-stickiness after application, the concentration of guanylate may be preferably 2.0 to 4.0% by weight.

By the way, since guanylate (guanosine 5'-monophosphate) is a kind of guanine (RNA component), RNA macromolecules (in particular, RNA macromolecules from which a conventional composition (eg, buffer solution) is extracted, in particular, In the case where the conventional composition contains guanylate, it is assumed that the conventional composition contains guanylate as a result of the formation of guanylate by the degradation of the RNA polymer. However, according to the technical idea of the present invention, the composition of the present invention is an RNA polymer and an RNA component other than guanylate [eg, guanosine 5'-phosphate other than guanylate (guanosine 5'-diphosphate and guanosine It differs from conventional compositions containing RNA macromolecules because it does not need to contain substantially 5'-triphosphate), adenosine 5'-phosphate, cytidine 5'-phosphate, uridine 5'-phosphate). .
Thus, the composition of the present invention may be completely free of (i) RNA macromolecules and / or RNA components other than guanylate.
The composition of the present invention may also contain (ii) no RNA component other than guanylate in an equivalent amount to guanylate. When the conventional composition containing RNA macromolecule contains guanylate produced by degradation of RNA macromolecule, each of the RNA components other than guanylate similarly produced by degradation of RNA macromolecule (eg, other than guanylate It is assumed that guanosine 5'-phosphate, adenosine 5'-phosphate, cytidine 5'-phosphate, uridine 5'-phosphate) is also included in the same amount as guanylate. On the other hand, since the composition of the present invention does not need to substantially contain RNA macromolecules, it can be avoided to contain any RNA component other than guanylate in an amount equivalent to guanylate. Examples of any RNA component other than guanylate (eg, guanosine 5'-phosphate, adenosine 5'-phosphate) other than guanylate that do not contain RNA components other than guanylate in equivalent amounts to guanylate (Cytidine 5'-phosphate, uridine 5'-phosphate, preferably all of them) is, for example, 1/2 wt.% Or less, preferably 1/5 wt. Those contained in an amount of at most 10% by weight, still more preferably at most 1/20% by weight, particularly preferably at most 1/50% by weight are mentioned. The composition of the present invention may also contain adenines (e.g., adenine, adenosine, adenosine 5'-monophosphate, adenosine 5'-diphosphate, adenosine 5'-triphosphate, glucosyl adenosine) as RNA components other than guanylate. May not be included.

Any water-soluble solvent can be used as the water-soluble medium. The water-soluble medium includes, for example, an aqueous solution, and a mixed solvent of an aqueous solution and an organic solvent. The aqueous solution may or may not have a buffering capacity. As the aqueous solution, for example, water (eg, distilled water, sterile distilled water, purified water, physiological saline), phosphate buffer, Tris-hydrochloric acid buffer, TE (Tris-EDTA) buffer, carbonate buffer, borax Acid buffer, tartaric acid buffer, glycine buffer, citrate buffer, acetate buffer may be mentioned. As the organic solvent contained in the mixed solvent, a hydrophilic organic solvent (eg, alcohol, acetone) is preferable. In the mixed solvent, the volume of the aqueous solution is not particularly limited, but is preferably larger than the volume of the organic solvent. The volume of the aqueous solution in the mixed solvent is more preferably 1.5 times or more, still more preferably 2 times or more, particularly preferably 3 times or more, 4 times or more or 5 times the volume of the organic solvent It may be more than. The aqueous medium may preferably be an aqueous solution, more preferably water.

The compositions of the invention can also be defined in terms of water content. For example, the water content in the composition of the present invention is not particularly limited as it varies depending on the types and concentrations of other components contained in the composition of the present invention and various conditions such as pH, etc. From the viewpoint of achieving higher viscosity gelation with an acid and / or improving the feeling in use, it may be, for example, 50% by weight or more, preferably 60% by weight or more, and more preferably 70% by weight or more. The water content may also be, for example, 99.5 wt% or less, preferably 99 wt% or less, more preferably 98 wt% or less. More specifically, the water content may be, for example, 50 to 99.5% by weight, preferably 60 to 99% by weight, more preferably 70 to 98% by weight.

The pH of the composition of the present invention is 4.0 to 7.0. The composition of the present invention can sufficiently support the achievement of gelation by guanylate when the pH is in the range of 4.0 to 7.0. The pH is preferably in the range of 4.5 to 6.5 from the viewpoint of achieving higher viscosity gelation and / or improving the feeling in use.

The composition of the present invention may further contain a cationic substance. Examples of cationic substances include metal ions, arginine, lysine, histidine, ammonium ions, and quaternary amines (eg, tetraalkylamines). Cationic substances can support the formation of gels by guanylate. The composition of the present invention can contain one or more (e.g., two or three) cationic substances. As the cationic substance, metal ions are preferred. As metal ions, monovalent metal ions (eg, sodium ion, potassium ion), divalent metal ions (eg, calcium ion, magnesium ion, zinc ion), trivalent metal ions (eg, aluminum ion) Although it may be mentioned, from the viewpoint of solubility etc., monovalent metal ions are preferred. The concentration of the cationic substance may be, for example, 0.01 to 5.0, preferably 0.1 to 3.0, and more preferably 0.2 to 1.5.

The compositions of the invention may also further comprise inosinic acid. Inosinic acid can enhance the action of guanylate in combination with guanylate. For example, inosinic acid can enhance refreshing feeling. Since inosinic acid is an umami component that is consumed on a daily basis, it is considered to be a component that is highly safe for subjects such as humans. Therefore, from the viewpoint of safety as well, inosinic acid is considered to be suitable for use as a cosmetic.

The concentration of inosinic acid contained in the composition of the present invention is not particularly limited because it also varies depending on the types and concentrations of other components contained in the composition of the present invention and various conditions such as pH. From the viewpoint of exerting the desired action, it may be, for example, 0.05% by weight or more, preferably 0.1% by weight or more, and more preferably 0.2% by weight or more. The concentration of inosinic acid is also, for example, 10% by weight or less, preferably 5% by weight or less, more preferably 2% by weight or less, and still more preferably 1% by weight or less, from the viewpoint of cost reduction due to reduction of use amount. Particularly preferably, the concentration may be 0.5% by weight or less.

The composition of the present invention can also be specified by the relative amount of inosinic acid to guanylate in terms of exerting the desired action. For example, the weight ratio of inosine to guanylate (inosinic / guanylate) may be, for example, in the range of 1/100 to 1/1. The weight ratio may preferably be in the range of 1/50 to 1/2, more preferably 1/20 to 1/5.

The composition of the present invention may also further comprise a polyol. As the polyol, for example, a dihydric alcohol (eg, ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, 1,4-dioxane) Butanediol, 2-butene-1,4-diol, 1,5-pentanediol, 1,2-pentanediol, isoprene glycol, hexylene glycol, diethylene glycol, dipropylene glycol), trihydric alcohol (eg, glycerin, tri) Examples include methylolpropane), tetrahydric alcohols (eg, diglycerin, pentaerythritol, 1,2,6-hexanetriol), and higher value alcohols. Examples of higher valence alcohols include sugar alcohols (eg, monosaccharide alcohols such as sorbitol and mannitol, disaccharide alcohols such as trehalose, and polysaccharide alcohols such as hyaluronic acid), and di- to tetra-valent as described above. Polymers of alcohol (eg, polyglycol, polyglycerin) can be mentioned. The polyhydric alcohol is preferably a di- to tetra-hydric alcohol, more preferably a di- or tri-hydric alcohol. One or more types of polyhydric alcohols can be used in combination.

The concentration of the polyol contained in the composition of the present invention is not particularly limited as it varies depending on various conditions such as the type and concentration of the other components contained in the composition of the present invention. It may be 2% by weight or more, preferably 0.5% by weight or more, more preferably 1.0% by weight or more, still more preferably 2.0% by weight or more, and particularly preferably 5.0% by weight or more . The concentration of the polyol is also, for example, 30% by weight or less, preferably 25% by weight or less, more preferably 20% by weight or less, still more preferably 15% by weight or less, particularly from the viewpoint of cost reduction due to reduction of use amount. Preferably, the concentration may be 10% by weight or less.

The composition of the present invention may further contain one or more (for example, two, three or four) water-soluble active ingredients. The water-soluble active ingredient used in the present invention is an active ingredient other than the above-mentioned ingredients and has any action (eg, biological action or chemical action) useful as a cosmetic.

The water-soluble active ingredient used in the present invention may be an electrolyte. Thus, in the compositions of the present invention, the water soluble active ingredient may be present as an ionic substance. The ionic substance includes, for example, an anionic substance having an anionic moiety, a cationic substance having a cationic moiety, and a zwitterionic substance having both an anionic moiety and a cationic moiety. The anionic moiety includes, for example, a carboxylate group, a phosphate group, a sulfonate group, a sulfate group and a ditorate group. The cationic moiety includes an ammonium group, a phosphonium group, a guanidino group and an imidazoyl group. The hydrogen atom in the ammonium group and the phosphonium group may be substituted (eg, mono-substituted, di-substituted, tri-substituted) with a group such as a hydrocarbon group (eg, alkyl).

The water-soluble active ingredient used in the present invention may also be a low molecular weight compound. The term "low molecular weight compound" refers to a compound having a molecular weight of 1,500 or less. Low molecular weight compounds are natural compounds or synthetic compounds. The molecular weight of the low molecular weight compound may be 1200 or less, 1000 or less, 900 or less, 800 or less, 700 or less, 600 or less, 500 or less, 400 or less, or 300 or less. The molecular weight of the low molecular weight compound may also be 30 or more, 40 or more, or 50 or more. The low molecular weight compounds include, for example, amino acids, oligopeptides, vitamins, nucleosides, nucleotides, oligonucleotides, monosaccharides, oligosaccharides, lipids, fatty acids, and metabolites thereof.

The water soluble active ingredient used in the present invention may also be a moisturizer, a skin lightening agent, a hair restorer, or an anti-wrinkle agent. Preferably, the water soluble active ingredient may also be a moisturizer, a hair restorer, or an anti-wrinkle agent. A combination of two or more (for example, two or three) selected from the group consisting of a moisturizer, a whitening agent, a hair restorer, and an anti-wrinkle agent (preferably, a moisturizer, a hair restorer, and an anti-wrinkle agent) Can also be used.

Humectants include pyrrolidone carboxylic acid, ascorbic acid 2-glucoside, polyaspartic acid, 3-acetyl-2-ethoxycarbonyl-2-methyl-1,3-thiazolidine-4-carboxylic acid, amino acids (eg, glutamic acid, asparagine) Acid, arginine, lysine, histidine, ornithine, glycine, alanine, valine, leucine, isoleucine, serine, threonine, asparagine, glutamine, cysteine, cystine, methionine, phenylalanine, tyrosine, tryptophan, proline, hydroxyproline) and mixtures thereof Glycylglycine, alanyl glutamine, dipeptide-2 (valyl tryptophan), dipeptide-4 (cysteinylglycine), dipeptide-8 (alanyl hydroxyproline), dipepti -9 (Guru Tamil lysine), dipeptide 11 (system sulfonyl lysine), dipeptide -17 (glycyl proline), dipeptide -19 (isoleucyl glutamic acid), and salts thereof. One or more humectants can be used in combination.

The salts include, for example, inorganic salts and organic salts. As the inorganic salt, for example, salts of metals (eg, monovalent metals such as sodium and potassium and divalent metals such as calcium, magnesium and zinc), inorganic acids (eg, hydrogen chloride, hydrogen bromide) And salts of sulfuric acid and phosphoric acid, and salts of inorganic bases (eg, ammonia). Examples of the organic salt include salts of organic acids (eg, acetic acid, lactic acid, citric acid, tartaric acid, maleic acid, fumaric acid, monomethyl sulfuric acid, aspartic acid, and glutamic acid), and organic bases (eg, ethylene diamine, propylene diamine, Salts of ethanolamine, monoalkylethanolamine, dialkylethanolamine, diethanolamine, triethanolamine, lysine, arginine, histidine, ornithine) can be mentioned.

Examples of skin lightening agents include vitamin C, vitamin C derivatives (eg, vitamin C glycosides such as L-ascorbic acid 2-glycoside), cysteine, tranexamic acid, hydroquinone, arbutin, ceramide, kojic acid, ellagic acid, plants Extracts as well as their salts are included. One or more kinds of skin lightening agents can be used in combination.

As a hair growth agent, for example, pantothenic acid and derivatives thereof, allantoin, biotin, mononitroguaiacol, adenosine, pentadecanoic acid glyceride, dialkyl monoamine derivative, choleus extract, chlorophyll, photosensitizer, estradiol, ethynyl estradiol, pyridoxine hydrochloride, thioxolone hydrochloride, minoxidil And sulfur, organic sulfur substances, dipeptide-9 (glutamyl lysine), and salts thereof. One or two or more hair growth agents can be used in combination.

Anti-wrinkle agents include, for example, alpha hydroxy acids, ascorbyl palmitate, ascorbyl tetrahexyl decanoate, acetyl hexapeptide-8, and salts thereof. One or more anti-wrinkle agents can be used in combination.

The composition of the present invention may be a defined composition. The term "defined" for the composition of the invention means that the ingredients and amounts contained in the composition of the invention are specified. The preparation of such defined compositions can be carried out by using known ingredients in specific amounts. Therefore, the composition of the present invention may be a material whose component or amount thereof is unknown, or a material whose component or amount may vary [eg, natural products (eg, animals such as animals, plants, fish, microorganisms, etc., Or non-living materials such as minerals) (eg, extracts, processed products) may not be included.

The composition of the present invention can also be defined in terms of thickness (coating feeling) at the time of coating. The composition of the present invention can have the characteristic that the vibration stress at the intersection of the storage elastic modulus G 'and the loss elastic modulus G' 'is 10 Pa or more. If the vibration stress at the intersection of the storage elastic modulus G ′ and the loss elastic modulus G ′ ′ is 10 Pa or more, a sufficient thickness (application feeling) at the time of application can be expected. The vibration stress at such an intersection is preferably 15 Pa or more, more preferably 20 Pa or more, and still more preferably 25 Pa or more. Such determination of the vibrational stress at the point of intersection can be performed as follows. First, the components are mixed, and the pH-adjusted composition is uniformly stirred in a 60 ° C. water bath and gradually cooled to room temperature to obtain a test sample. Next, strain dependence measurement of dynamic viscoelasticity may be performed using a rheometer (AR-G2, TA Instruments) for a test sample (measuring jig: aluminum cone plate diameter 40 mm, cone Angle 2 °, measurement temperature: 35 ° C.).

The composition of the present invention also contains other components such as thickeners, stabilizers, pH adjusters, preservatives, UV inhibitors, perfumes, dyes, etc. other than the above-mentioned thickening components (eg, guanylate). It may be. The specific types and amounts of these components can be set as appropriate.

As thickeners other than the above-mentioned thickening component, for example, carrageenan, dextrin, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyacrylic acid, polymethacrylic acid, carboxyvinyl polymer (carbomer), ( And acrylic acid / alkyl acrylate (C10-30) copolymers, xanthan gum. When the composition of the present invention contains such a thickener in addition to the above-mentioned thickening component, the weight ratio of the thickening agent to the above-mentioned thickening component (eg, guanylate) (thickener / thickening property) The components) may for example be less than 1.0, preferably less than 0.8, more preferably less than 0.4, even more preferably less than 0.2, particularly preferably less than 0.1.

Examples of the stabilizer include ascorbic acid, sodium metabisulfite and EDTA.

Examples of pH adjusting agents include aqueous solutions (buffer solutions) as described above, acidic substances such as hydrochloric acid, and basic substances such as sodium hydroxide.

Examples of preservatives include ethyl parahydroxybenzoate, sodium benzoate, salicylic acid, sorbic acid, parabens (such as methyl paraben and propyl paraben), and sodium bisulfite.

Examples of UV inhibitors include UV absorbers (eg, t-butyl methoxydibenzoylmethane, ethylhexyl methoxycinnamate, oxybenzone-3), and UV scattering agents (eg, titanium oxide, zinc oxide).

As the flavor, for example, limonene, citral, menthol, rose oil, rose oil can be mentioned.

Examples of the pigment include organic pigments (eg, red pigment such as red No. 201, blue pigment such as blue No. 404, orange pigment such as orange No. 203, yellow pigment such as yellow No. 205, green pigment such as green No. 3) Organic lake pigments such as zirconium lake, natural pigments such as chlorophyll, and inorganic pigments (eg, white pigments such as titanium oxide, colored pigments such as iron oxide, extender pigments such as talc, pearl pigments such as mica) Be

The composition of the present invention is effective (e.g., 0.01 mg or more) at a desired site (e.g., skin, hair, body hair, scalp) of a subject (e.g., a mammal such as a human, animals such as birds, reptiles) It can be used by applying 100 g). When the subject is a human, a human (the same or different human) who can be a user or an applicator of the composition of the present invention can enjoy the effect of feeling of use. Even when the subject is an animal, since the composition of the present invention is usually used and applied to animals by humans, humans who can be users can enjoy the effect of feeling in use. Preferably, the subject is a human. The condition of the subject to which the composition of the present invention is applied may be that the above site has a healthy condition, or the above site may have an abnormal condition (eg, a disease) . Such abnormal conditions include, for example, rough skin, dryness of the skin, scale, turnover disorder, skin diseases (eg, dermatitis such as atopic dermatitis), hair loss, stains, wrinkles, freckles.

The composition of the present invention may further be a moisturizer, a skin-whitening agent, a hair restorer, or an anti-wrinkle agent (preferably a moisturizer, a hair-restorant, or an anti-wrinkle agent). In addition, the composition of the present invention is at least two selected from the group consisting of a moisturizer, a skin lightening agent, a hair restorer, and an anti-wrinkle agent (preferably a moisturizer, a hair restorer and an anti-wrinkle agent) (eg, It may be an agent having two or three functions. For preparation of such an agent, one or more water-soluble active ingredients are appropriately selected, and any method applicable to, for example, a desired site (eg, skin, hair, hair, scalp) according to a conventional method It can be carried out by preparing a formulation in the form of

Preferably, the composition of the present invention may be a humectant. In this case, the moisturizer of the present invention may preferably further contain a polyol as described above. The humectant of the present invention may further contain, as a water-soluble active ingredient, other humectants as described above, in addition to the polyol.

The composition of the present invention can be used, for example, as a cosmetic for a site such as skin, hair or scalp. The products for the skin include, for example, emulsions, lotions, creams, gels, essences and face masks. Products for hair include, for example, hair emulsions, hair treatments, hair conditioners, shampoos, hair lotions. The product for the scalp includes, for example, a hair restorer. Preferred cosmetics include, for example, creams, gels, hair conditioners and hair treatments.

EXAMPLES The present invention will next be described in more detail by way of examples, which should not be construed as limiting the invention thereto.

Preparation of Compositions of Examples 1 to 6 and Comparative Examples 1 to 7
The polyol was added to the component (A) or polymer which was previously stirred and dispersed in water. As the component (A), guanylate (guanosine 5'-monophosphate) and / or inosinic acid (inosine 5'-monophosphate) (both not salts) were used. Subsequently, the water-soluble active ingredient was added, well stirred at room temperature, and the pH of the obtained composition was adjusted as described in the table using a pH adjuster. Thereafter, the mixture was uniformly stirred in a 60 ° C. water bath and gradually cooled to room temperature to obtain a test sample.

<Visual confirmation of gel-like composition>
The test sample prepared as described above is filled into a 50 ml glass vial and allowed to stand overnight. The next day, the glass vial was turned upside down, observed visually, and evaluated according to the following criteria.
A: The gel does not fall.
B: The gel maintains its shape slowly falling by gravity.
C: The glass bottle drips as it is turned over. Do not maintain shape.

<Breaking stress of gel-like composition>
The test sample prepared as described above was filled in a 50 ml glass vial, and the breaking stress was measured at 25 ° C. using a FUDOH rheometer RTC-3010D-CW (manufactured by Leotec Co., Ltd.). The obtained measured values were evaluated according to the following criteria.
A: 5 g or more B: 0.5 g to 4.9 g C: 0.49 g or less

<Evaluation of thickness at the time of application>
The test sample prepared as described above was subjected to strain dependence measurement of dynamic viscoelasticity using a rheometer (AR-G2, Tea Instrument) (measuring jig: aluminum cone plate diameter 40 mm) , Cone angle 2 °, measurement temperature: 35 ° C). The thickness at the time of application was evaluated according to the following criteria by evaluating the vibrational stress at the intersection of the storage elastic modulus G ′ and the loss elastic modulus G ′ ′.
A: Vibrational stress at the intersection of storage elastic modulus G 'and loss elastic modulus G''is 25 Pa or more B: Vibrational stress at the intersection of storage elastic modulus G' and loss elastic modulus G '' is 10 to 25 Pa
C: Vibrational stress at the intersection of storage elastic modulus G ′ and loss elastic modulus G ′ ′ is less than 10 Pa D: Storage elastic modulus G ′ does not intersect loss elastic modulus G ′ ′

The storage modulus G 'is an indicator of the elastic properties of the material. The loss modulus G ′ ′ is an indicator of the viscous nature of the material. In general, a viscous cosmetic preparation exhibits a relationship of storage elastic modulus G '> loss elastic modulus G' 'in a range where vibrational stress is very small, and when the preparation is stressed, loss elastic modulus G' '> Storage elastic modulus G'. As the intersection point of the storage elastic modulus G 'and the loss elastic modulus G' 'is on the high stress side, it means that a large force is required to break the internal structure. Therefore, it indicates that the thickness at the time of application increases as the intersection point of the storage elastic modulus G ′ and the loss elastic modulus G ′ ′ becomes higher stress side. The thickness at the time of application is an objective index of the feeling of application (the comfort when the preparation is spread), and generally, when the thickness at application is increased, the improvement of the application feeling can be expected.

<Sensory evaluation test>
[Evaluation method]
The use test was conducted by 10 professional evaluation panels, and the application feeling, the refreshing feeling, the dry feeling, and the non-stickiness were evaluated in 5 steps according to the following evaluation criteria, and their average points were calculated.

[Evaluation criteria]
5 points: very good 4 points: good 3 points: normal 2 points: somewhat bad 1 point: bad

Judgment criteria
A: Average point of 4 points or more B: Average point of 3 points or more to less than 4 points C: Average point of 2 points or more to less than 3 points D: Average point of less than 2 points

As a result, the composition (pH 4.0 to 7.0) containing guanosine phosphate (2.0% by weight or more) in the water-soluble medium was able to gel sufficiently and was excellent in the feeling of use ( Tables 1 to 3).

Therefore, it was confirmed that a composition (pH 4.0 to 7.0) containing guanosine phosphoric acid (2.0% by weight or more) in a water-soluble medium is suitable for use as a cosmetic.

Claims

Containing at least 2.0% by weight of guanylate in an aqueous medium,
Gel cosmetic composition having a pH of 4.0 to 7.0.
The gel cosmetic composition according to claim 1, further comprising a cationic substance.
The gel-like cosmetic composition according to claim 1 or 2, wherein the cationic substance is a metal ion.
The gel cosmetic composition according to any one of claims 1 to 3, wherein the concentration of guanylate is 2.0 to 4.0% by weight.
The gel cosmetic composition according to any one of claims 1 to 4, which has a pH of 4.5 to 6.5.
The gel cosmetic composition according to any one of claims 1 to 5, further comprising inosinic acid.
The gel cosmetic composition according to claim 6, wherein the concentration of inosinic acid is 0.1% by weight or more.
The gel cosmetic composition according to any one of claims 1 to 7, further comprising a water-soluble active ingredient.
The gel cosmetic composition according to any one of claims 1 to 8, further comprising a polyol.
The gel cosmetic composition is (i) completely free of RNA macromolecules and / or RNA constituents other than guanylate, or (ii) RNA constituents other than guanylate with guanylate The gel cosmetic composition according to any one of claims 1 to 9, which is not contained in the same amount.
The gel cosmetic composition according to any of the preceding claims, wherein the gel cosmetic composition is a defined composition.
The gel cosmetic composition according to any one of claims 1 to 11, wherein the gel cosmetic composition is a moisturizing agent.