WO2019034207A3 - Method for producing a biocompatible layer on an implant surface - Google Patents

Method for producing a biocompatible layer on an implant surface Download PDF

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Publication number
WO2019034207A3
WO2019034207A3 PCT/DE2018/100708 DE2018100708W WO2019034207A3 WO 2019034207 A3 WO2019034207 A3 WO 2019034207A3 DE 2018100708 W DE2018100708 W DE 2018100708W WO 2019034207 A3 WO2019034207 A3 WO 2019034207A3
Authority
WO
WIPO (PCT)
Prior art keywords
implant
implant surface
layer
producing
hydroxyl groups
Prior art date
Application number
PCT/DE2018/100708
Other languages
German (de)
French (fr)
Other versions
WO2019034207A2 (en
Inventor
Albrecht Berg
Matthias Schnabelrauch
Jürgen Weisser
Andreas Pfuch
Oliver Beier
Original Assignee
Verein zur Förderung von Innovationen durch Forschung, Entwicklung und Technologietransfer e.V. (Verein INNOVENT e.V.)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verein zur Förderung von Innovationen durch Forschung, Entwicklung und Technologietransfer e.V. (Verein INNOVENT e.V.) filed Critical Verein zur Förderung von Innovationen durch Forschung, Entwicklung und Technologietransfer e.V. (Verein INNOVENT e.V.)
Publication of WO2019034207A2 publication Critical patent/WO2019034207A2/en
Publication of WO2019034207A3 publication Critical patent/WO2019034207A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/02—Methods for coating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/08—Coatings comprising two or more layers

Abstract

The invention relates to a method for producing a biocompatible layer on an implant surface of an implant consisting of polyetheretherketone. The aim of the invention is to specify a possibility, by which the positive properties of PEEK as an implant material can be improved with regard to growing-in behavior, biocompatibility and resorbability of the coating. According to the invention, said aim is achieved by a method for producing a biocompatible layer on an implant surface of an implant, consisting of polyetheretherketone, in which first the implant surface is provided with hydroxyl groups by the reduction of the keto group with hydroxyl groups or by applying a SiOx coating, then a coupling layer is applied by means of a coupling reagent selected from the substance class of mono-polyisocyanates, whereby a link to the hydroxyl groups of the implant surface is carried out via urethane bonds, and finally a biopolymer layer is applied by means of a modified biopolymer selected from the substance classes of polysaccharides and/or glycosaminoglycans, whereby a link to the coupling layer is carried out via urethane and/or urea bonds. Furthermore, the oligoester methacrylates and the oligoester urethane methacrylates can be cross-linked by means of photoinitiators on the substrate surface.
PCT/DE2018/100708 2017-08-14 2018-08-13 Method for producing a biocompatible layer on an implant surface WO2019034207A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017118508.9 2017-08-14
DE102017118508.9A DE102017118508B4 (en) 2017-08-14 2017-08-14 Process for the production of a biocompatible layer on an implant surface

Publications (2)

Publication Number Publication Date
WO2019034207A2 WO2019034207A2 (en) 2019-02-21
WO2019034207A3 true WO2019034207A3 (en) 2019-04-18

Family

ID=63371449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2018/100708 WO2019034207A2 (en) 2017-08-14 2018-08-13 Method for producing a biocompatible layer on an implant surface

Country Status (2)

Country Link
DE (1) DE102017118508B4 (en)
WO (1) WO2019034207A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113750290A (en) * 2020-06-03 2021-12-07 深圳先进技术研究院 Polyether-ether-ketone composite implant and preparation method and application thereof
CN112869897B (en) * 2021-01-14 2022-01-25 南京医科大学附属口腔医院 Zirconia implant surface treatment method
CN113398329B (en) * 2021-06-08 2023-03-14 广西民族大学 Surface modification method of polyether-ether-ketone artificial skeleton
CN114230843A (en) * 2022-01-11 2022-03-25 季华实验室 Polyether-ether-ketone surface modification method
CN114989475B (en) * 2022-05-30 2023-07-18 浙江大学 Preparation method and product application of biological functionalized surface modified polyether-ether-ketone material
CN115400267B (en) * 2022-10-10 2023-03-03 吉林大学 Preparation method and application of rosmarinic acid-loaded polyether-ether-ketone composite material

Citations (7)

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WO2002000271A1 (en) * 2000-06-24 2002-01-03 Victrex Manufacturing Limited Bio-compatible polymeric materials
DE102008036520A1 (en) * 2008-08-06 2010-02-18 Gabriel, Matthias, Dr. New hydrogel-forming polymer with an antimicrobial effect for binding on a surface, where the hydrogel-forming polymer has a quaternary ammonium group for destroying a cell membrane of a microorganism
WO2013050554A1 (en) * 2011-10-05 2013-04-11 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Carbohydrate functionalised surfaces
KR20130046283A (en) * 2011-10-27 2013-05-07 한국과학기술원 Hyaluronic acid catechol conjugate and use thereof
EP2631332A1 (en) * 2012-02-21 2013-08-28 Innovent e.V. Method for metalizing a substrate
WO2015103023A1 (en) * 2013-12-30 2015-07-09 Boston Scientific Scimed, Inc. Functionalized lubricious medical device coatings
WO2016134819A1 (en) * 2015-02-24 2016-09-01 Universität Konstanz Material for bone implants, and a method for producing same

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FR2915088B1 (en) 2007-04-18 2010-03-12 Cadorel Catherine COMPOSITE ENDO-BONE COMPOSITE IMPLANT WITH OPTIMIZED MECHANICAL ATTACHMENT AND METHOD FOR MANUFACTURING SUCH IMPLANT
JP5280664B2 (en) 2007-10-25 2013-09-04 株式会社 資生堂 Surface modification method and surface modification material
DE102007051782B4 (en) 2007-10-30 2017-02-02 Aesculap Ag Implant for replacing a facet joint surface
US20090276053A1 (en) 2008-04-22 2009-11-05 Timothy Brown Coated Implants
US20110143127A1 (en) 2009-12-11 2011-06-16 Biomet Manufacturing Corp. Methods for coating implants
CN102946912B (en) 2010-05-07 2017-09-08 扩散技术公司 With enhanced hydrophilic medical implant
PL218575B1 (en) 2011-02-28 2014-12-31 Fundacja Rozwoju Kardiochirurgii Im Prof Zbigniewa Religi Medical implant and method for preparing the surface layers on the medical implants
GB2496168C (en) 2011-11-03 2020-01-29 Biomet Uk Healthcare Ltd Prosthesis component
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Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000271A1 (en) * 2000-06-24 2002-01-03 Victrex Manufacturing Limited Bio-compatible polymeric materials
DE102008036520A1 (en) * 2008-08-06 2010-02-18 Gabriel, Matthias, Dr. New hydrogel-forming polymer with an antimicrobial effect for binding on a surface, where the hydrogel-forming polymer has a quaternary ammonium group for destroying a cell membrane of a microorganism
WO2013050554A1 (en) * 2011-10-05 2013-04-11 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Carbohydrate functionalised surfaces
KR20130046283A (en) * 2011-10-27 2013-05-07 한국과학기술원 Hyaluronic acid catechol conjugate and use thereof
EP2631332A1 (en) * 2012-02-21 2013-08-28 Innovent e.V. Method for metalizing a substrate
WO2015103023A1 (en) * 2013-12-30 2015-07-09 Boston Scientific Scimed, Inc. Functionalized lubricious medical device coatings
WO2016134819A1 (en) * 2015-02-24 2016-09-01 Universität Konstanz Material for bone implants, and a method for producing same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"PEEK Biomaterials Handbook", 1 January 2012, ELSEVIER, ISBN: 978-1-4377-4463-7, article ALEXANDRA H.C. POULSSON ET AL: "Surface Modification Techniques of Polyetheretherketone, Including Plasma Surface Treatment", pages: 145 - 161, XP055522059, DOI: 10.1016/B978-1-4377-4463-7.10010-7 *
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NOISET O ET AL: "ADHESION AND GROWTH OF CACO2 CELLS ON SURFACE-MODIFIED PEEK SUBSTRATA", JOURNAL OF BIOMATERIALS SCIENCE. POLYMER EDITION, VSP, UTRECHT, NL, vol. 11, no. 7, 1 January 2000 (2000-01-01), pages 767 - 786, XP001033578, ISSN: 0920-5063, DOI: 10.1163/156856200744002 *

Also Published As

Publication number Publication date
DE102017118508B4 (en) 2021-10-28
WO2019034207A2 (en) 2019-02-21
DE102017118508A1 (en) 2019-02-14

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