WO2019033361A1

WO2019033361A1 - Blood collection apparatus and control device thereof

Info

Publication number: WO2019033361A1
Application number: PCT/CN2017/097927
Authority: WO
Inventors: 李泉
Original assignee: 深圳华迈兴微医疗科技有限公司; 李泉
Priority date: 2017-08-17
Filing date: 2017-08-17
Publication date: 2019-02-21

Abstract

Provided are a blood collection apparatus and control device thereof, suitable for use in the field of medical instruments, said blood collection apparatus comprising: a microneedle assembly (1), said microneedle assembly (1) comprising a first microfluidic control channel (11) of a releasable anesthetic and a second microfluidic control channel (12) for collecting blood; a first motion assembly (2) which drived said microneedle assembly (1) to inject the anesthetic into the epidermis layer by means of the first microfluidic control channel (11); a second motion assembly (3) which drives the microneedle assembly (1) to collect blood from the skin by means of the second microfluidic control channel (12); a blood storage apparatus (4) in communication with the second microfluidic control channel (12) and used for storing collected blood. In the blood collection apparatus, a plurality of small-diameter microneedles are arranged in an orderly manner into a microneedle array (111, 121), the wound formed by the needle puncturing the skin being very small; furthermore, during the process of blood collection, the depth of penetration of the microneedle can be accurately controlled, releasing the anesthetic upon puncturing the epidermis layer of the skin, and when anesthesia is complete, penetrating the dermis layer and drawing blood; during the entire process, the patient does not experience pain and thus painless blood collection is achieved.

Description

Description: A blood stasis device and its control device

[0001] The invention belongs to the field of medical instruments, and in particular relates to a blood collection device and a control device thereof.

Background technique

[0002] Collecting blood to provide a test sample is one of the conventional detection means in clinical tests. In the prior art, the commonly used blood collection method is to puncture the vein and collect blood, or to acupuncture the tip of the finger, and then extrude the blood and collect it. This method is mostly used for the regular detection of blood sugar level in diabetic patients.

[0003] However, in the research and practice of the prior art, the applicant of the present application found that the prior art has the following defects: venous puncture blood collection is usually more painful, and generally requires professional medical personnel to carry out Reduce the damage; the way of acupuncture the tip of the finger is less bloody and more painful, and for children, because the child has a fear of acupuncture, and is not willing to take blood, this will undoubtedly increase the blood collection work. Difficulty, so the above blood collection methods can no longer meet the needs of modern medical care.

technical problem

Embodiments of the present invention provide a blood collection device and a control device thereof, which are directed to solving the problem that a blood collection method such as a vein puncture or a needle tip of a finger in the prior art still causes a pain in a person to be blood-sucked.

Problem solution

Technical solution

[0005] The embodiment of the present invention is achieved by a blood collection device, the blood collection device comprising: a microneedle assembly, the microneedle assembly comprising a first microfluidic channel capable of releasing an anesthetic, and a second blood collection device Microfluidic channel;

[0006] driving the microneedle assembly to inject a first motion component of an anesthetic into the epidermis layer through the first microfluidic channel;

[0007] driving a second movement component of the microneedle assembly to collect blood from the skin through the second microfluidic channel; [0008] communicating with the second microfluidic channel for storing the collected blood Blood storage device.

[0009] The embodiment of the present invention further provides another blood collection device, the blood collection device includes: a housing, the bottom plate of the housing is provided with an array of micro pinholes; [0010] The housing is placed with:

[0011] a microneedle assembly, the microneedle assembly comprising a first microfluidic channel capable of releasing an anesthetic, and a second microfluidic channel capable of collecting blood;

[0012] driving the microneedle assembly to inject a first motion component of the anesthetic into the epidermis layer through the first microfluidic channel;

[0013] driving the microneedle assembly to collect blood from the skin through the second microfluidic channel;

[0014] the upper portion of the housing has a cover enclosing the microneedle assembly, the first motion assembly, the second motion assembly, and the blood storage device into the housing;

[0015] the cover has:

[0016] a pressing hole corresponding to the first motion structure and the second motion structure;

[0017] in communication with the second microfluidic channel, a blood storage device for storing the collected blood.

[0018] An embodiment of the present invention further provides a blood collection control device, the device comprising: a control panel;

[0019] a power source connected to the control board;

[0020] coupled to the control panel, the first motion component that can drive the movement of the first motion structure;

[0021] coupled to the control panel, the second motion component that can drive the movement of the second motion structure;

[0022] a vacuum pump connected to the control panel;

[0023] The mounting position of the disposable blood collection device can be installed.

Advantageous effects of the invention

Beneficial effect

[0024] The blood collection device provided by the invention is arranged in an array of micro-needle arrays by a plurality of tiny micro-needle arrays. In the blood collection, the micro-needle invades the skin tissue of the blood-collected person, due to precise control of the micro-needle penetration depth. In the epidermis, without contact with the painful nerves, the drug such as anesthetic is quickly released at this depth, and the skin wound is small. When the anesthesia is completed, the micro-needle is again controlled to enter the capillaries of the dermis to draw blood, and the patient does not feel pain. Achieve painless blood collection.

Brief description of the drawing

DRAWINGS

1 is a schematic structural view of a blood collection device according to an embodiment of the present invention;

2 is a schematic structural diagram of an anesthetic storage device of a blood collection device according to an embodiment of the present invention; 3 is a schematic view showing a microneedle array arrangement of a blood collection device according to an embodiment of the present invention;

4 is a schematic structural diagram of a substrate of a blood collection device according to an embodiment of the present invention;

5 is a cross-sectional view of a C-C surface of a blood collection device according to an embodiment of the present invention;

6 is a schematic structural view of a deflector of a blood collection device according to an embodiment of the present invention;

7 is an assembled view of a cap and a blood storage device of a blood collection device according to an embodiment of the present invention;

8 is a schematic view showing a cover structure of a blood collection device according to an embodiment of the present invention;

[0033] FIG. 9 is an assembled view of the internal structure of a blood collection device according to an embodiment of the present invention;

10 is a schematic structural view of a bottom plate of a blood collection device according to an embodiment of the present invention;

11 is a schematic view showing the overall structure of another blood collection device according to an embodiment of the present invention;

12 is a schematic structural diagram of a blood collection control device according to an embodiment of the present invention.

Embodiments of the invention

The present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It is understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

[0038] The blood collection device provided by the embodiment of the invention includes a microneedle assembly, the microneedle assembly includes a first microfluidic channel capable of releasing an anesthetic, and a second microfluidic channel capable of collecting blood; Transmitting, by the first microfluidic channel, a first moving component of the anesthetic to the epidermal layer; driving the second moving component of the microneedle assembly to collect blood from the skin through the second microfluidic channel; and the second microfluidic control The channel is connected to a blood storage device for storing the collected blood. The microneedle in the blood collection device has a small diameter, which is up to the nanometer level, so that it invades the skin tissue of the blood collector, and the skin wound formed by the blood collection device is very small, so that the blood collector does not substantially feel the pain, and the blood collection device is in the blood collection device. An anesthetic storage/release device is also provided, which can control the depth of the anesthetic in the epidermis layer of the painless nerve during the blood collection process, and then inject into the dermis layer to draw blood, thereby further achieving painlessness. Blood collection.

[0039] The specific implementation of the present invention will be described in detail below with reference to specific embodiments.

1 to 12, in an embodiment of the present invention, the blood collection device includes: a microneedle assembly 1 including a first microfluidic channel 11 capable of releasing an anesthetic, and blood collectable a second microfluidic channel 12; a first motion component 2 that drives the microneedle assembly 1 to inject an anesthetic into the epidermal layer through the first microfluidic channel 11 a second motion component 3 that drives the microneedle assembly 1 to collect blood from the skin through the second microfluidic channel 12; a blood storage device 4 for storing the collected blood in communication with the second microfluidic channel 12 .

[0041] As an embodiment of the present invention, the first microfluidic channel 11 has a stepped channel having a diameter that is large and small, and a channel having a smaller diameter is adjacent to a tip end portion of the microneedle. The depth of the smaller diameter portion of the channel may be set according to the depth of the dermis layer of the skin tissue of the blood collector. For example, the thickness of the dermis layer of the general human body is about 1.0 mm, so that the depth of the microneedle channel of the smaller diameter portion is Can be set to about 1.0mm, so that it can release the anesthetic to the human epidermis, about 200um depth, but not reach the 200 _U m-1000um capillary-containing dermis, not to puncture the skin tissue Capillaries or venous blood vessels. The first microfluidic channel 11 having a stepped channel can control the flow rate of the anesthetic through the diameter of the step channel, that is, the flow rate of the anesthetic through the larger diameter end of the step channel is larger, and then flows into the The flow rate of the anesthetic at the end of the stepped channel having a smaller diameter is relatively small. Therefore, the flow rate of the anesthetic can be changed from large to small, and can be slowly injected into the skin tissue of the blood donor to make the local nerve of the blood donor. Temporarily loses the feeling, especially the pain, to achieve painless blood collection. In addition, since the microneedle has a very small pore size, it can be made into a nanometer scale, and when it invades the skin tissue of the blood-collected person, the wound formed by the skin tissue of the blood-collected person is very small, and the depth of invasion is generally not very high. Deep, so the blood collector will not feel the pain.

[0042] As a preferred embodiment of the present invention, the microneedles on the microneedle assembly 1 can be made of a degradable material having good toughness or good biocompatibility to improve the toughness of the microneedle having a small pore size. It is prevented from being broken during the pressure-collection process because the toughness of the micro-needle is not good, and remains in the body of the blood-collected person, causing damage to the body of the blood-collected person. Or even if it remains, it is biocompatible and can be quickly degraded to avoid damage to the body of the blood donor.

[0043] In an embodiment of the invention, the first microfluidic channel 11 comprises: a hollow first microneedle array 111, an anesthetic storage device 112, and a channel 113 for injecting an anesthetic into the first microneedle array. The anesthetic storage device 112 includes: an anesthetic storage chamber 1121; an anesthetic release device 1122 located on the anesthetic storage chamber 1121; and a sealing structure 1123 enclosing the anesthetic into the anesthetic storage chamber 1121.

[0044] As an embodiment of the present invention, the hollow first microneedle array 111 may be a microneedle array fixed on a substrate 114. For example, the microneedle array may be a 10*10 square array, that is, An array of infusion microneedle with 100 ports is formed. Each microneedle is arranged in an orderly manner at a preset distance for infusion. An adhesive liquid plate 115 is disposed on the back surface of the substrate 114 opposite to the first microneedle array 111, and an anesthetic flow guiding groove 1151 and a blood guiding groove 1152 are disposed on the joint surface of the liquid guiding plate 115 and the substrate 114. On the opposite side of the joint surface of the liquid-conducting plate 115 and the substrate 114, a sharp puncturing needle 1125 is provided.

[0045] wherein the piercing needle 1125 can be formed by injection molding, and the molding process is simple. However, the liquid guide plate 115 and the substrate 114 may be joined by various welding methods such as ultrasonic/hot-melt welding/plasma welding/healing. The substrate 114 can form an internal stepped channel in a MEMS process.

[0046] In an embodiment of the present invention, the anesthetic storage chamber 1121 may be composed of two mutually connected, identically configured reservoir chambers, wherein each reservoir chamber has a volume of about 5-150 uL, both of which are Used to store anesthesia. The volume of the two interconnected cavities is approximately 10-300 uL, allowing approximately 10-300 uL of anesthetic to be stored at one time. The dosage of the anesthetic stored in the anesthetic storage chamber 1121 is sufficient to meet the need for anesthesia before blood draw, which provides a prerequisite for painless blood collection. In addition, the two communicating cavities can make the two of them reach a relatively balanced state under the force of pressing down, so that the puncture needle 1125 can pierce the soft film 1124 at the same time, and the same can ensure micro. The needle invades the skin of the blood donor's skin and the depth is substantially synchronized.

[0047] In an embodiment of the invention, the anesthetic release device 1122 includes a soft membrane 1124 disposed at the bottom of the anesthetic storage chamber 1121 and a piercing needle 1125. When the blood is collected, the soft film 1124 is punctured by the puncturing needle 1125, and the anesthetic stored in the anaesthetic storage chamber 1121 can flow into the anesthetic guide groove 1151 through the hollow passage of the puncturing needle 1125, and pass through The anesthetic guide groove 1151 flows into the channel of the first microneedle array 111 corresponding thereto, and then is injected into the skin tissue of the blood donor by the channel of the first microneedle array 111.

[0048] As an embodiment of the present invention, after the blood collection device is manufactured, the anesthetic may be injected into the anesthetic storage cavity 1121 in advance, and then sealed by the sealing structure 1123 adapted thereto, so as to avoid The sealed anesthetic is contaminated or spilled by contaminants such as dust during transportation or storage.

[0049] As a preferred embodiment of the present invention, a mouth 1126 may be disposed in the center of the sealing structure 1123. After the anesthetic is injected into the anesthetic storage cavity 1121 and sealed, the mouth 1126 may be kept in place. a state in which the air pressure in the anesthetic storage chamber 1121 is relatively balanced with the air pressure of the outside to prevent the soft film 1124 from protruding downward and being stabbed due to the pressure difference between the inside and outside of the anesthetic storage chamber 1121 after the anesthetic is injected. The broken needle 1125 is punctured, so that the anesthetic in the anesthetic storage chamber 1121 is released in advance. Let it out, causing waste.

[0050] As another preferred embodiment of the present invention, the sealing structure 1123 may be disposed as a centrally extending convex boss structure, the mouth 1126 is located on the boss, and the mouth 1126 may be configured as a funnel. Shape, in order to facilitate the injection of anesthetic and observe whether it is overflowing. In addition, the edge of the boss structure is an annular groove 1127. During the production process, if the anesthetic is overfilled, it may first flow into the annular groove 1127, and the overflowing anesthetic may be blown off by a spray gun. The anesthetic that avoids spillage directly flows into the interior of the blood collection device, maintaining the overall hygienic state of the blood collection device.

[0051] As a further embodiment of the present invention, a soft space is provided between the soft film 1124 and the puncturing needle 1125, and an anesthetic agent 注入 is injected into the anesthetic storage chamber 1121, and the soft film 1124 is subjected to pressure. Protruding downward, the safety distance can prevent the puncture needle 1125 from directly piercing the soft film 1124, thereby causing leakage phenomenon, and keeping the blood collection device clean and safe.

[0052] In an embodiment of the present invention, the blood collection device may be provided with a sealing cover/seal plug/seal membrane (not shown) or the like on the mouthpiece 1126 to The 1126 is sealed to keep the anesthetic from spilling during storage, transportation, and use and to keep it clean and safe.

[0053] In the embodiment of the present invention, when it is required to release the anesthetic in the anesthetic storage chamber 1121 for anesthesia, the anesthetic storage chamber 1121 can be moved downward by manual operation or mechanical control (eg, motor drive). And the puncturing needle 1125 can pierce the soft membrane 1124 such that the anesthetic in the anesthetic storage chamber 1121 can flow through the passage in the anesthetic release device 1122 to the hollow first microneedle array 111 and through the first microneedle The channels of the array 111 are injected into the epidermal layer of the skin tissue of the human body to effect anesthesia.

[0054] In an embodiment of the invention, the second microfluidic channel 12 comprises: a hollow second microneedle array 121, which can transport the collected blood to the pipeline of the blood storage device 4 (not shown in the figure) ). The second microneedle array 121 can be fixedly disposed on the substrate 114, and the microneedles in each row of the second microneedle array 121 are disposed between each two rows of the first microneedle array 111. Further, each microneedle in the second microneedle array 121 is located at a central position of a square array surrounded by every four microneedles of the first microneedle array 111, that is, a five-child chess structure is formed. The microneedles in the second microneedle array 121 can form a 9*9 square microneedle array|J, that is, a microneedle array formed with 81 microneedles. When the blood collection operation is performed, the microneedle assembly 1 moves downward integrally, and drives the hollow first microneedle array 111 and the hollow second microneedle array 121 to be aligned Under exercise. Wherein, during the downward movement, the anesthetic stored in the anesthetic storage chamber 1121 may flow into the first microneedle array channel 113 through the hollow passage of the anesthetic release device 1122, and pass through the first microneedle array channel 113. The first microfluidic channel 11 in the corresponding first microneedle array 111 is injected into the skin tissue of the human body.

[0055] However, the second microfluidic channel 12 in the second microneedle array 121 can be inserted into the epidermal layer of the skin tissue of the human skin, and can continue to penetrate the human body as the external force increases. The dermis of the skin tissue pierces the capillaries or venous blood vessels, allowing it to bleed and draw blood.

[0056] It should be noted that the arrangement manner of the micro-needle in the first micro-needle array 111 and the second micro-needle array 121 may be other arrangement manners, for example, a ring-shaped array which may be arranged in a spaced relationship, It can be set according to actual needs, and there is no restriction here.

[0057] In the embodiment of the present invention, the second microneedle array 121 can extract about 7-8 uL, that is, the blood collection device can collect blood for about 600 uL at a time, but the blood collection volume can satisfy various common times. Blood biochemistry experiments.

[0058] In the embodiment of the present invention, the blood storage device 4 includes: a blood storage cavity 41; a blood injection channel 42 disposed on the blood storage cavity 41, and the blood injection channel 42 is provided with a first single guide a structure (not shown); a blood discharge passage 43 disposed on the blood storage chamber 41, the blood discharge passage 43 is provided with a second unidirectional structure (not shown); The permeable, water-impermeable portion 44 of the blood storage chamber 41.

[0059] wherein, the first unidirectional structure and the second unidirectional structure may be a one-way valve structure, so that blood can only be injected along the blood injection channel 42 and flow out through the blood discharge channel 43 without being reversed. Flow back to the human body and cause damage to the human body, and ensure the smooth progress of blood extraction. In addition, the permeable water-impermeable portion 44 disposed on the blood storage cavity 41 may be a gas permeable and water-impermeable film; in the blood sputum, air residing in the blood storage cavity 41 may be externally transmitted through the film. The connected device, such as the vacuum pump, extracts the air content inside the blood storage chamber 41, that is, lowers the air pressure, so that the air pressure of the blood storage chamber 41 forms a pressure difference with the blood pressure of the human body, and the blood flowing out of the human body can be inhaled. Into the blood storage chamber 41. However, the membrane is impervious to water to prevent the outside water from entering the blood storage chamber 41 to dilute/contaminate the blood sample during blood drawing/storing, thereby ensuring the reliability of the blood sample, and also the blood. The premise that the test results are true and reliable. [0060] In an embodiment of the invention, the first motion assembly 2 includes a housing 5 disposed in the blood collection device, and an elastic suspension bracket 21 for suspending the microneedle assembly 1. The elastic suspension bracket 21 includes: a frame body 211 composed of a press-deformable elastic arm; and a movement defining the micro-needle assembly 1 such that the first micro-needle array 111 is in a first motion structure (not shown) The limit structure 212 that enters the skin layer is driven.

[0061] In the embodiment of the present invention, the elastic suspension bracket 21 can clamp the four end angles of the microneedle assembly 1 through the clamping structure provided at the end thereof, respectively, to fix the microneedle assembly 1 . The clamping structure may be an inwardly bent structure extending from the two protruding ends of the frame body 211, or may be a buckle formed by the overlapping ends of the two elastic arms of the frame body 211 and the microneedle assembly 1 Structure, etc.

[0062] In a preferred embodiment of the present invention, the frame body 211 may be an obtuse angle structure composed of two elastic arms. When the first outer force is received at the obtuse apex of the frame body 211, elastic deformation and obtuse angle may occur. The angle becomes larger, and thus, the microneedle assembly 1 can be driven to move downward. When the microneedle assembly 1 moves downward, the first microfluidic channel 11 on the first microneedle array 111 can be driven into the epidermis layer of the human body, and the crucible is stopped from continuing to penetrate due to the resistance of the limiting structure 212. . In this case, the first external force can be set to allow the anesthetic to be injected into the epidermal layer of the human body through the first microfluidic channel 11 on the anesthetic release device 1122 and the first microneedle array 111, and The first external force is used to maintain the efficacy of anesthesia. Then, the second pressure can be continuously applied to the frame body 211 so that the stopper structure 212 is also elastically deformed. Thereafter, the second microfluidic channel 12 on the second microneedle array 121 in the microneedle assembly 1 can continue to penetrate the dermis layer of the human skin tissue and puncture the veins or capillaries of the human body to allow blood to flow out and carry out Draw blood. Since the anesthetic is injected before the blood collection and the diameter of the microneedle is small, the blood-collected person does not feel pain at all, so that painless blood collection can be achieved.

[0063] It should be noted that, in practical applications, the retention time and size of the first pressure/second pressure may be different according to the age of the blood collector, the location of the blood collection, and the sensitivity of the blood collection site to pain. To be flexible. For example, when the part where blood collection is required is not sensitive to pain, the first pressure and the second pressure may be set to be slightly larger, and the remaining time is shorter; the second pressure is slightly larger. For example, when the blood collector's age is small and the skin tissue is delicate, the force of the first pressure and the second pressure can be appropriately set to a small point, and the remaining time can be slightly shorter.

In the embodiment of the present invention, the first microneedle array 111 and the second microneedle array 121 may be composed of retractable microneedles, and the first microneedle array 111 and the second microneedle array 121 may be in an external force. Different under the influence of Invade skin tissue. That is, when the elastic suspension bracket 21 is subjected to the first pressure 吋, the microneedle assembly 1 moves downward, causing the first microfluidic channel 11 on the first microneedle array 111 to move downward and invade the skin tissue of the human body, and The second microfluidic channel 12 on the second microneedle array 121 contracts and does not invade the skin. When the elastic suspension bracket 21 is subjected to the second pressure 吋, the microneedle assembly 1 continues to move downward. Thereafter, the first microfluidic channel 11 on the first microneedle array 111 is retracted, and the second microneedle array 121 is retracted. The second microfluidic channel 12 extends and invades the dermal layer of the skin tissue. Of course, depending on the blood collection site and the like, the first microfluidic channel 11 on the first microneedle array 111 can be further advanced after receiving the second pressure ,, and the anesthetic release is further performed on the blood collection site. Achieve better painless blood collection.

In an embodiment of the invention, the second motion component 3 of the blood collection device includes a pressing assembly 31 that releases the limiting structure 212. The pressing component can be a pressing structure formed by the protrusion 2121 on the limiting structure 212 and the bottom plate 51 of the blood collecting device and the groove/hole 311 matching the protrusion 2121. When the blood collection device needs to be assembled, the limiting structure 212 can be fixed to the blood collection device by the protrusion 2121 and the groove/hole 311 on the bottom plate 51. After the blood collection is completed or the blood collection device needs to be disassembled, the protrusion 2121 can be pressed to separate the protrusion 2121 from the groove/hole 311, that is, the limiting structure 212 is released, and the microneedle assembly 1 can be separated.幵 Skin tissue.

An embodiment of the present invention further provides another blood collection device, comprising: a housing 5, the bottom plate 51 of the housing 5 is provided with a micro pinhole array 511; the housing 5 is provided with: a microneedle assembly 1 comprising a first microfluidic channel 11 for releasing an anesthetic, and a second microfluidic channel 12 for collecting blood; driving the microneedle assembly 1 through the first microfluidic channel a first motion component 2 for injecting an anesthetic into the epidermis; a second motion component 3 for driving the microneedle assembly 1 to collect blood from the skin through the second microfluidic channel 12; the upper portion of the housing 5 having the microneedle assembly 1 The first motion component 2, the second motion component 3, and the blood storage device 4 are encapsulated in the cover 7 of the housing 5; the cover 7 has: a pressing hole corresponding to the first motion structure 6 and the second motion structure 8 71; a blood storage device 4 for storing the collected blood in communication with the second microfluidic channel 12.

In the embodiment of the present invention, the cover 7 further has a positioning hole/positioning pin 72 so that it can be fixed on the housing 5 through the positioning hole/positioning pin 72 to avoid the cover 7 The casing 5 is slid off and dropped during transportation, storage, or sales, and the components inside the casing 5 are contaminated by external dust or the like.

[0068] In the embodiment of the present invention, the side of the bottom plate 51 of the casing 5 that is in contact with the skin is also attached with a protective film ( Not shown in the figure), it is possible to prevent dust and the like from adhering to the bottom plate 51 of the blood collection device, or the contaminants enter the inside of the blood collection device through the microneedle array hole 511 on the bottom plate 51, and in the blood collection, dust and the like The human body is in contact with the human body, so that the hygienic and safety of the blood collection device can be further ensured.

[0069] In the embodiment of the present invention, the blood storage device 4 includes: a blood storage cavity 41; disposed on one side of the blood storage cavity 41, through a catheter (not shown) and the second micro control a first pipe joint 45 and a second pipe joint 46 communicating with the flow passage 12; a first one-way structure (not shown) connected to the first pipe joint 45 and the second pipe joint 46, and a second single guide a structure (not shown); on the opposite side of the blood storage chamber 41, a position corresponding to the second unidirectional structure is provided with a reverse unidirectional structure (not shown); The opposite side of the cavity 41 is provided with a blood drawing hole 47 at a position corresponding to the first one-way structure, and the blood drawing hole 47 is provided with a gas permeable and impermeable portion 44; the gas permeable and water permeable portion 44 can be connected to a vacuum pump of an external device. 11 connected; at a position corresponding to the reverse unidirectional conduction structure on the opposite side of the blood storage cavity 41, a blood discharge hole 48 communicating with the reverse unidirectional conduction structure; a raft of the blood storage cavity 41 Flexible film seal at the mouth Wherein the outer flexible film attached thereto a thin rigid plate (not shown).

[0070] In an embodiment of the invention, the gas permeable, water impermeable portion 44 mounted on the blood draw hole 47 may allow gas to pass through without allowing moisture to pass through, and the external device vacuum pump 11 of the blood collection device may pass through the gas permeable, water impermeable portion 44. The air in the blood storage chamber 41 is extracted to be in a negative pressure/vacuum environment, and the blood of the human body flows to the blood storage chamber 41 due to the pressure difference, thereby achieving rapid blood collection, shortening the blood draw, and reducing the human body. Pain. The permeable, water-impermeable portion 44 blocks outside moisture from entering the blood storage chamber 41, diluting or contaminating the taken blood sample. The gas permeable, impermeable portion 44 can be a gas permeable, water impermeable film.

[0071] In an embodiment of the invention, a flexible film seal is applied to the mouth end of the blood storage cavity 41, and a rigid thin plate is attached to the outside of the flexible film. The rigid sheet can further prevent the blood sample inside the blood storage chamber 41 from splashing due to an external force impact during blood collection. The flexible film sealing between the rigid thin plate and the blood storage cavity 41 can separate the blood storage cavity 41 from the rigid thin plate, and can completely seal the mouth end of the blood storage cavity 41 to prevent pollutants. From the edge gap of the rigid sheet into the interior of the blood storage chamber 41, the collected blood can be further ensured The sample is not contaminated.

[0072] In the embodiment of the present invention, the cover 7 of the blood collection device is provided with a sliding slot 73 connected to the external device, so that the blood collection device can be slidingly pushed and pulled with the external device through the sliding slot 73, similarly The drawer type structure improves the convenience of use of the blood collection device.

[0073] An embodiment of the present invention further provides a blood collection control device, the device comprising: a control board 9; a power source 10 connected to the control board 9; and a control board 9 for driving the movement of the first motion structure 6 a first motion component 2; a second motion component 3 coupled to the control panel 9 to drive movement of the second motion structure 8; a vacuum pump 11 coupled to the control panel 9; a mounting location for the disposable blood collection device. The first motion component 2 and the second motion component 4 are respectively composed of a linear motor and an auxiliary mechanism capable of linear pressing motion.

[0074] Wherein, in the embodiment of the present invention, the linear motor can directly convert electrical energy into mechanical motion of linear motion without requiring other intermediate conversion mechanism transmission devices, and has high positioning accuracy, simple structure, and stable motion. , low noise, small friction of moving parts and so on.

[0075] In an embodiment of the invention, the device further comprises a display screen 12 connected to the control panel 9, by which the current blood collection process can be displayed, for example, the current anesthetic can be displayed on the display screen 12. Use the dose, the interval of injection of anesthesia, the volume of blood collection, the location of blood collection, the depth of acupuncture, etc., in order to remind the blood collection staff to adjust or end the blood collection, and improve the efficiency and accuracy of blood collection.

[0076] In an embodiment of the invention, the device further comprises a sound playing device 13 connected to the control panel 9, which can be used to play the process data of the blood collection during the blood collection, for example, the injection of the anesthetic injection, the injection of the anesthetic Dose, microneedle intrusion into the skin, blood flow and other sound data to prompt the blood collection worker to adjust and end the abnormal blood collection, or to instruct the non-professional blood collection worker to perform the correct blood collection procedure For example, the sugar friends can perform blood collection operations and detect blood sugar levels at home according to the blood collection operation steps played by the blood collection device. That is, the versatility and convenience of use of the blood collection device can be further improved.

[0077] In the embodiment of the present invention, the device further includes an activation switch 14 connected to the control panel 9. When the blood collection is required, the control panel 9 can control the opening and closing of the activation switch 14, and drive the blood collection device. Perform blood collection or stop blood collection. [0078] In the embodiment of the present invention, the mounting position of the device is provided with a positioning pin/positioning hole 72 corresponding to the positioning hole/positioning pin on the blood collection device, so that the blood collection device can be fixedly mounted on the mounting position. The blood collection device is avoided, and the blood collection device moves to pull the skin tissue of the blood collector to cause pain; or the blood collection device is not installed in place, and the normal blood collection operation cannot be performed.

[0079] In the embodiment of the present invention, the device further includes a blood collection device releasing the switch (not shown), and when the blood collection is finished or an abnormal situation occurs during the blood collection, the blood collection worker can press The release is closed, and the positioning pin/positioning hole is separated from the positioning hole/positioning pin of the blood collection device, so that the blood collection operation can be stopped, thereby ensuring the safety of blood collection and facilitating the abnormality of the blood collection worker during the blood collection process. Adjustment.

[0080] In an embodiment of the invention, the device further includes a fixed structure (not shown) that can secure the device to the arm. The fixing structure may be a structure such as a bandage, a Velcro, a buckle structure or the like. In the blood collection, the blood collection device can be fixed to the blood donor's arm through the fixed structure, and the blood collection device can be prevented from being displaced during the blood collection process and involved in the skin tissue of the blood-collected person, thereby increasing the pain. Further improving the convenience of use of the blood collection device.

[0081] In the embodiment of the present invention, the device can be configured as a watch type structure, and the device is small in size, and can be made into a U disk having a length X of 50×18, and the whole device is very compact and can be worn on the hand. It is very convenient to carry out blood collection. Moreover, the blood collection device of the watch type structure is used for blood collection, and the microneedle provided inside the device is not seen in the whole process, which can reduce the fear of the blood collection person (especially a child), so This can, to a certain extent, reduce the difficulty of the blood collection worker to increase blood collection because of the resistance of the blood collector. In addition, during the blood collection process, the blood collection device does not see blood during the blood drawing, which can be easily performed for some blood-sucking blood collectors.

[0082] In an embodiment of the invention, the device further comprises an attention transfer device 15 connected to the control panel 9, the attention transfer device 15 may be a video/music player, a picture display, a game machine, an aroma Release the device, in the blood collection, you can play some videos/music, pictures, games, etc. to attract the attention of the blood collector, so that the blood collector (especially the child) can watch videos, pictures or play games. In the process of easily completing the blood draw, without crying, reducing the trouble of blood collection workers to collect blood.

The blood collection device provided by the present invention comprises an array of microneedles composed of a plurality of micro-needle (nano-scale) micro-needle arrays, and the micro-needle invades the skin tissue of the blood-collected person, and the skin wound formed by the micro-needle is very small. Being picked The blood is basically not feeling pain; and there is also an anesthetic storage/release device, in which the anesthetic can be released into the epidermal layer of the skin tissue of the blood donor by the blood collection device, and then pumped after the anesthesia is completed. Blood, so it can further achieve painless blood collection. In addition, the blood collection device is a disposable detachable structure, which is convenient to install and use, and effectively ensures that blood is not cross-contaminated due to sharing of a blood collection needle, etc., and the collected blood is also ensured. The sample is not contaminated and affects the final test result judgment.

The above is only the preferred embodiment of the present invention, and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection of the present invention. Within the scope.

Claims

Claim

A blood collection device, characterized in that: the blood collection device comprises:

a microneedle assembly comprising a first microfluidic channel capable of releasing an anesthetic, and a second microfluidic channel capable of collecting blood;

Driving the microneedle assembly to inject a first motion component of the anesthetic into the epidermis layer through the first microfluidic channel;

a second moving component that drives the microneedle assembly to collect blood from the skin through the second microfluidic channel;

A blood storing device for storing the collected blood, the blood collecting device of claim 1, wherein the first microfluidic channel comprises:

a hollow first microneedle array;

Anesthetic storage device;

An anesthetic is injected into the channel of the first microneedle array.

The blood collection set according to claim 2, wherein said anesthetic storage device comprises:

Anesthetic storage chamber;

An anesthetic release device located on the storage cavity;

The anesthetic is enclosed in a sealed structure of the storage cavity.

The blood collection set according to claim 1, wherein said second microfluidic channel comprises:

a hollow second microneedle array;

The collected blood can be delivered to a conduit of the blood storage device.

A blood collection device according to claim 1, wherein said blood storage device comprises a blood storage chamber;

a blood injection channel disposed on the blood storage cavity, the blood injection channel is provided Provided with a first one-way structure;

a blood discharge passage disposed on the cavity, wherein the blood discharge passage is provided with a second one-way structure;

a gas permeable, watertight portion disposed on the cavity.

[Claim 6] The blood collection device according to claim 1, wherein the first motion assembly includes a resilient suspension bracket disposed on a housing of the blood collection device to suspend the microneedle assembly.

[Claim 7] The blood collection device according to claim 6, wherein the elastic suspension bracket comprises a frame body composed of a press-deformable elastic arm;

The movement of the microneedle assembly is defined such that the first microneedle array enters the constraining structure of the skin layer under the action of the first motion structure.

[Claim 8] The blood collection device according to claim 7, wherein the second motion component comprises:

a pressing assembly that releases the stop structure.

[Claim 9] A blood collection device, wherein the blood collection device comprises:

a housing, the bottom plate of the housing is provided with an array of micro pinholes;

The housing is placed with:

The upper portion of the housing has a cover enclosing the microneedle assembly, the first motion assembly, the second motion assembly, and the blood storage device into the housing;

The cover has:

a pressing hole corresponding to the first moving structure and the second moving structure; a blood storage device connected to the second microfluidic channel for storing the collected blood [Claim 10] The blood collection device according to claim 9, wherein the cover further has a positioning pin hole/positioning pin.

[Claim 11] The blood collection device according to claim 9, wherein a protective film is attached to a side of the bottom plate of the casing that is in contact with the skin.

[Claim 12] The blood collection device according to claim 9, wherein the blood storage device comprises

Blood storage chamber;

a first pipe joint and a second pipe joint which are disposed on one side of the blood storage cavity and communicate with the second micro control flow passage through a conduit;

a first one-way structure and a second one-way structure respectively connected to the first pipe joint and the second pipe joint;

On a side opposite to the blood storage cavity, a position corresponding to the second one-way structure is provided with a reverse unidirectional structure; on the opposite side of the blood storage cavity, with the first single guide The corresponding position of the through structure is provided with a blood drawing hole, and the blood drawing hole is provided with a gas permeable and impermeable portion; the gas permeable and water impermeable portion can be connected with a vacuum pump of an external device; on the opposite side of the blood storage cavity, a position corresponding to the reverse unidirectional conduction structure is provided with a blood discharge hole communicating with the reverse unidirectional conduction structure;

The mouth end of the blood storage cavity is sealed with a flexible film; the outer side of the flexible film is attached with a rigid thin plate.

[Claim 13] The blood collection device according to claim 9, wherein the cover is provided with a chute connected to the external device.

[Claim 14] A blood collection control device, wherein the device comprises:

Control panel

a power source connected to the control board;

a first motion component coupled to the control panel for driving movement of the first motion structure; a second motion component coupled to the control panel for driving movement of the second motion structure; a vacuum pump coupled to the control panel; A mounting position for a disposable blood collection device can be installed.

[Claim 15] The blood collection device according to claim 14, wherein the first motion component and the second motion component are respectively composed of a linear motor that can perform a linear pressing motion and an auxiliary mechanism.

[Claim 16] The blood collection set according to claim 14, wherein the apparatus further comprises a display screen connected to the control panel.

[Claim 17] The blood collection set according to claim 14, wherein the apparatus further comprises a sound playback device coupled to the control panel.

[Claim 18] The blood collection set of claim 14, wherein the apparatus further comprises an activation switch coupled to the control panel.

[Claim 19] The blood collection device according to claim 14, wherein the mounting position is provided with a positioning pin/positioning hole corresponding to the positioning hole/positioning pin on the blood collection device.

[Claim 20] The blood collection device according to claim 14, wherein the device further comprises a blood collection device release switch, the release pin is pressed, the positioning pin/positioning hole and the blood collection device The positioning hole/positioning pin is detached.

[Claim 21] The blood collection set according to claim 14, wherein the apparatus further includes a fixing structure that can fix the apparatus to the arm.

[Claim 22] The blood collection device according to claim 14, wherein the device is a watch type structure.

[Claim 23] The blood collection set according to claim 14, wherein the apparatus further comprises an attention transfer device coupled to the control panel.