WO2019032144A1 - Feed supplement bolus with active yeast - Google Patents

Feed supplement bolus with active yeast Download PDF

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Publication number
WO2019032144A1
WO2019032144A1 PCT/US2018/020351 US2018020351W WO2019032144A1 WO 2019032144 A1 WO2019032144 A1 WO 2019032144A1 US 2018020351 W US2018020351 W US 2018020351W WO 2019032144 A1 WO2019032144 A1 WO 2019032144A1
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WO
WIPO (PCT)
Prior art keywords
yeast
dietary supplement
bolus
ruminant
acid
Prior art date
Application number
PCT/US2018/020351
Other languages
French (fr)
Inventor
Peter H. Franz
Marty J. Nelson
Michael L. Nelson
Bradley Welding Kolstad
Nathan C. Upah
David J. Muysson
Dennis M. Mckilligan
Original Assignee
Techmix, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Techmix, Llc filed Critical Techmix, Llc
Priority to EP18845261.9A priority Critical patent/EP3570683A4/en
Publication of WO2019032144A1 publication Critical patent/WO2019032144A1/en

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves

Definitions

  • the present invention relates generally to a feed supplement preparation for administration to ruminant animals and, more particularly, to a solid tablet or bolus that provides an effervescent release of calcium and dried active yeast into the reticulum of large ruminants for the prevention or treatment of hypocalcemia and to provide a positive increase in additional dietary supplement materials.
  • hypocalcemia Prevention of low blood calcium, commonly referred to as hypocalcemia, is of great concern to the producer. Because of the calcium required for hypocalcemia, is of great concern to the producer. Because of the calcium required for hypocalcemia, is of great concern to the producer. Because of the calcium required for hypocalcemia, is of great concern to the producer. Because of the calcium required for hypocalcemia, is of great concern to the producer. Because of the calcium required for hypocalcemia, is of great concern to the producer. Because of the calcium required for hypocalcemia
  • the bolus may also contain acid and base ingredients which react to
  • a unique formulation for a bovine supplement for fresh cows that delivers calcium chloride, calcium carbonate, magnesium, potassium and other electrolytes in a stable pressed solid bolus form which also contains dried live active yeast.
  • the successful incorporation of dried stable active yeast in the formulation in which the yeast remains active in a shelf-stable compressed dry bolus dosage form greatly enhances the effectiveness of the supplement.
  • the formulation also includes sufficient amounts of acidic and basic components which react to generate a gas release in an aqueous medium to accomplish effervescent release of calcium and dried active yeast into the reticulum via a solid bolus dosage form.
  • the present invention provides a unique formulation for a bovine supplement to be administered to fresh cows that delivers calcium chloride, calcium carbonate, magnesium, potassium and other beneficial constituents in an anhydrous pressed solid bolus dosage form and which also contains dried live active yeast.
  • the successful incorporation of live active yeast which remains stable in a pressed bolus has greatly enhanced the effectiveness of the supplement.
  • the present invention further has successfully added dried stable active yeast to an anhydrous pressed solid bolus dosage form.
  • the supplement not only provides needed calcium, but it also produces a
  • the supplement treats the two biggest problems encountered by cows right after calving - low blood calcium and low feed intake and demonstrates direct economic benefit from treatment. It is believed that the yeast successfully enhances microbial action stimulating rumen fermentation.
  • the yeast is in the form of micro-granules of dehydrated yeast coated with a homogeneous hydrophobic substance such as a fat or fatty acid that stabilizes the yeast against physical and chemical stresses including heat and compression.
  • a homogeneous hydrophobic substance such as a fat or fatty acid that stabilizes the yeast against physical and chemical stresses including heat and compression.
  • the sugar alcohol is selected from sorbitol, maltitol, erythritol, mannitol, and combinations thereof.
  • the acid constituent, which reacts with the carbonate to provide an effervescence is selected from citric acid, sorbic acid, formic acid and combinations thereof.
  • One example of a successful product has about 2-3% live yeast, about 8% calcium carbonate and about 60% calcium chloride.
  • the formula may contain varying amounts of dried live active yeast between 1% and 5% with 2%-3% being typical.
  • a typical dose is 2-110g solid boluses. This invention has been described herein in

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
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  • Zoology (AREA)
  • Polymers & Plastics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Birds (AREA)
  • Fodder In General (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A ruminant dietary supplement in the form of a pressed shelf-stable solid pill or bolus that effervesces when administered into the reticulum of a ruminant and releases calcium and dried active yeast.

Description

FEED SUPPLEMENT BOLUS WITH ACTIVE YEAST
CROSS-REFERENCED TO RELATED APPLICATIONS
Not applicable
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
Not applicable
BACKGROUND OF THE INVENTION
I. Field of the Invention
The present invention relates generally to a feed supplement preparation for administration to ruminant animals and, more particularly, to a solid tablet or bolus that provides an effervescent release of calcium and dried active yeast into the reticulum of large ruminants for the prevention or treatment of hypocalcemia and to provide a positive increase in additional dietary supplement materials.
II. Related Art
It is known to administer several essential
nutrients required by lactating cows following
parturition. Prevention of low blood calcium, commonly referred to as hypocalcemia, is of great concern to the producer. Because of the calcium required for
colostrogenesis and subsequent lactogenesis, the
requirement for calcium increases greatly during the periparturient period. Clinical hypocalcemia is characterized by a blood calcium concentration drop below a critical threshold resulting in a potentially life threatening state of recumbency. Solid boluses
containing calcium chloride have been produced and administered to animals orally. The bolus may also contain acid and base ingredients which react to
effervesce in the reticulum of the animal. One such bolus is described in U.S. Patent Publication No.
2016/0058760 Al. Another acute problem associated with cows is that in the days leading up to parturition their dry matter intake decreases, in some cases profoundly. As selection for higher producing genetics continues to be emphasized the severity of this periparturient dry matter intake suppression becomes of greater consequence. Dry matter intake reduction of 20-25% in the first 24-48 hours after calving is common, independent of calcium status. Should the dry matter intake not increase in concert with milk production the fresh cow is at an increased risk for hypocalcemia (milk fever), displaced abomasum, ketosis, and poor lactational performance. Dry matter intake and nutrient absorption following calving are also influenced by. the transition of the rumen microflora to a diet greater in carbohydrate content, specifically rapidly fermentable starch, and lower in fiber than they were exposed to prepartum. To rapidly foster the growth and prefoliation of starch digesting bacteria in accordance with energetic demands there is a need for a dietary supplement that acts as food for these bacteria and ultimately enables the cow to maintain a higher level of dry matter feed intake and resulting in more available energy to support lactation in the immediate period after calving.
SUMMARY OF THE INVENTION
By means of the present invention, there is provided a unique formulation for a bovine supplement for fresh cows that delivers calcium chloride, calcium carbonate, magnesium, potassium and other electrolytes in a stable pressed solid bolus form which also contains dried live active yeast. The successful incorporation of dried stable active yeast in the formulation in which the yeast remains active in a shelf-stable compressed dry bolus dosage form greatly enhances the effectiveness of the supplement. The formulation also includes sufficient amounts of acidic and basic components which react to generate a gas release in an aqueous medium to accomplish effervescent release of calcium and dried active yeast into the reticulum via a solid bolus dosage form.
DETAILED DESCRIPTION
The present invention provides a unique formulation for a bovine supplement to be administered to fresh cows that delivers calcium chloride, calcium carbonate, magnesium, potassium and other beneficial constituents in an anhydrous pressed solid bolus dosage form and which also contains dried live active yeast. The successful incorporation of live active yeast which remains stable in a pressed bolus has greatly enhanced the effectiveness of the supplement.
It has been found that administering ruminant supplements containing large amounts of calcium is more successful if a stable pressed solid bolus is used so that the animal swallows the bolus whole into the fluid in the reticulum where it dissolves and reacts.
Effervescent release of calcium has also been found to be very effective.
The present invention further has successfully added dried stable active yeast to an anhydrous pressed solid bolus dosage form. Thus, the supplement not only provides needed calcium, but it also produces a
previously undocumented positive increase in dry matter feed intake and milk production. In this manner, the supplement treats the two biggest problems encountered by cows right after calving - low blood calcium and low feed intake and demonstrates direct economic benefit from treatment. It is believed that the yeast successfully enhances microbial action stimulating rumen fermentation.
The yeast is in the form of micro-granules of dehydrated yeast coated with a homogeneous hydrophobic substance such as a fat or fatty acid that stabilizes the yeast against physical and chemical stresses including heat and compression. Such a yeast form is available from Lallemand S. A. of Blagnac, France.
One successful combination had the following range of ingredients.
Product Ingredients (wt)
Figure imgf000005_0001
The sugar alcohol is selected from sorbitol, maltitol, erythritol, mannitol, and combinations thereof. The acid constituent, which reacts with the carbonate to provide an effervescence is selected from citric acid, sorbic acid, formic acid and combinations thereof.
One example of a successful product has about 2-3% live yeast, about 8% calcium carbonate and about 60% calcium chloride. The formula may contain varying amounts of dried live active yeast between 1% and 5% with 2%-3% being typical. A typical dose is 2-110g solid boluses. This invention has been described herein in
considerable detail in order to comply with the patent statutes and to provide those skilled in the art with the information needed to apply the novel principles and to construct and use embodiments of the example as required. However, it is to be understood that the invention can be carried out by specifically different devices and that various modifications can be accomplished without departing from the scope of the invention itself.
What is claimed is:

Claims

1. A ruminant dietary supplement in the form of a pressed shelf-stable solid pill or bolus that effervesces when administered into the reticulum of a ruminant and releases calcium and dried live active yeast.
2. A ruminant dietary supplement as in claim 1 wherein the amount of dried live active yeast is from 1% to 5% (wt) of the bolus.
3. Ά ruminant dietary supplement wherein the amount of dried live active yeast is 2-3% (wt) .
4. A ruminant dietary supplement as in claim 1 wherein the yeast is live yeast in the form of particles coated with a hydrophobic substance that, reduces
degradation of the yeast and enables it to remain stable when incorporated in a pressed solid bolus.
5. A ruminant dietary supplement as in claim 2 wherein the live yeast is in the form of particles coated with a hydrophobic substance that reduces degradation of the yeast and enables it to remain stable when
incorporated in a pressed solid bolus.
6. A ruminant dietary supplement as in claim 1 wherein the effervescence is produced by the reaction of an acid and a carbonate.
7. A ruminant dietary supplement as in clam 6 wherein the acid includes citric acid and the base is calcium carbonate.
8. A ruminant dietary supplement as in claim 1 comprising about 2-3% (wt) live yeast, about 8% calcium carbonate (wt), about 60% calcium chloride (wt) and about 5% of an acid constituent (wt) .
9. A ruminant dietary supplement as in claim 8 wherein the acid constituent is selected from citric acid, scorbic, formic acid and combinations thereof.
PCT/US2018/020351 2017-08-07 2018-03-01 Feed supplement bolus with active yeast WO2019032144A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP18845261.9A EP3570683A4 (en) 2017-08-07 2018-03-01 Feed supplement bolus with active yeast

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15/670,285 US11523625B2 (en) 2017-08-07 2017-08-07 Feed supplement bolus with active yeast
US15/670,285 2017-08-07

Publications (1)

Publication Number Publication Date
WO2019032144A1 true WO2019032144A1 (en) 2019-02-14

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EP (1) EP3570683A4 (en)
WO (1) WO2019032144A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11529310B2 (en) 2020-12-08 2022-12-20 Ruminant Biotech Corp Limited Devices and methods for delivery of substances to animals

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922342A (en) * 1990-10-01 1999-07-13 Pharmacia & Upjohn Company Lateral edge coated controlled release pharmaceutical compositions
US20100303778A1 (en) * 2007-12-26 2010-12-02 Jean-Luc Simon Composition for human and/or animal nutrition, uses thereof and yeasts
CN102114112A (en) * 2011-02-28 2011-07-06 辽宁盛生医药集团有限公司 Effervescent tablet for improving immunity and preparation method thereof
WO2012017363A1 (en) * 2010-08-02 2012-02-09 Vetalis Sarl Effervescent solid galenic forms for animals
US20130344005A1 (en) * 2012-06-22 2013-12-26 Laboratoires Aditec Bolus for treating hypocalcaemia in ruminants

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3843800A (en) 1968-11-08 1974-10-22 Arend Langejan Preparation of active dried baker's yeast
FR2806417B1 (en) 2000-03-16 2003-12-26 Lallemand Sa COATED PARTICLES CONTAINING LIVING MICROORGANISMS, PROCESS FOR THE PRODUCTION AND APPLICATION OF SAID PARTICLES IN PHARMACEUTICAL, DIETETIC OR FOOD COMPOSITIONS
US7597916B2 (en) 2005-09-22 2009-10-06 Castillo Alejandro R Livestock anti-acid composition
FR2909685B1 (en) 2006-12-08 2012-12-21 Lallemand Sas ACTIVE DRIED DRIED YEASTS AND FOODS CONTAINING THEM
DE202009002804U1 (en) 2009-02-27 2010-07-22 Almapharm Gmbh & Co. Kg Composition for buffering unphysiologically low pH values in the rumen
IT1393710B1 (en) 2009-04-29 2012-05-08 Graal Srl OROBUCCAL COMPOSITIONS CONTAINING A MIXTURE OF LUTEIN AND ZEAXANTHIN.
JP6421170B2 (en) 2013-03-14 2018-11-07 ライジェル ファーマシューティカルズ， インコーポレイテッド Protein kinase C inhibitor and use thereof
FR3025104B1 (en) 2014-08-29 2017-11-24 Hy-Nutrition IMMEDIATE RELEASE BOLUS

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922342A (en) * 1990-10-01 1999-07-13 Pharmacia & Upjohn Company Lateral edge coated controlled release pharmaceutical compositions
US20100303778A1 (en) * 2007-12-26 2010-12-02 Jean-Luc Simon Composition for human and/or animal nutrition, uses thereof and yeasts
WO2012017363A1 (en) * 2010-08-02 2012-02-09 Vetalis Sarl Effervescent solid galenic forms for animals
CN102114112A (en) * 2011-02-28 2011-07-06 辽宁盛生医药集团有限公司 Effervescent tablet for improving immunity and preparation method thereof
US20130344005A1 (en) * 2012-06-22 2013-12-26 Laboratoires Aditec Bolus for treating hypocalcaemia in ruminants

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3570683A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11529310B2 (en) 2020-12-08 2022-12-20 Ruminant Biotech Corp Limited Devices and methods for delivery of substances to animals

Also Published As

Publication number Publication date
EP3570683A1 (en) 2019-11-27
US20190037884A1 (en) 2019-02-07
EP3570683A4 (en) 2020-12-09
US11523625B2 (en) 2022-12-13

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