WO2019025857A3 - Additively manufactured functional dosage forms - Google Patents
Additively manufactured functional dosage forms Download PDFInfo
- Publication number
- WO2019025857A3 WO2019025857A3 PCT/IB2018/000974 IB2018000974W WO2019025857A3 WO 2019025857 A3 WO2019025857 A3 WO 2019025857A3 IB 2018000974 W IB2018000974 W IB 2018000974W WO 2019025857 A3 WO2019025857 A3 WO 2019025857A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dosage form
- printed
- outer shell
- dosage forms
- additively manufactured
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/10—Processes of additive manufacturing
- B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
- B29C64/118—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
- B33Y70/10—Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
- B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
- B29K2105/0035—Medical or pharmaceutical agents
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Ceramic Engineering (AREA)
- Civil Engineering (AREA)
- Composite Materials (AREA)
- Structural Engineering (AREA)
- Mechanical Engineering (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
Abstract
3D printed functional dosage forms, and methods for making thereof are disclosed. In one aspect of the disclosure, a dosage form is presented that includes an outer shell printed from a first material and at least one inner core containing an active pharmaceutical ingredient (API) disposed within the outer shell. The dosage form includes an opening structure extending from an outer surface of the outer shell to the at least one inner core. The dosage form may include a plurality of pH sensitive mucoadhesive projections printed from a third material and extending from the outer shell. The dosage form may include a plug printed from the second or third material within the opening structure and can include an outer cap printed over the plug from a fourth material. The dosage form also may include an internal hollow cavity such that the dosage form is buoyant in an aqueous solution.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762539303P | 2017-07-31 | 2017-07-31 | |
US62/539,303 | 2017-07-31 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2019025857A2 WO2019025857A2 (en) | 2019-02-07 |
WO2019025857A3 true WO2019025857A3 (en) | 2019-03-21 |
WO2019025857A8 WO2019025857A8 (en) | 2019-06-13 |
Family
ID=65233545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2018/000974 WO2019025857A2 (en) | 2017-07-31 | 2018-07-30 | Additively manufactured functional dosage forms |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2019025857A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201813186D0 (en) * | 2018-08-13 | 2018-09-26 | Univ Central Lancashire | Solid dosage from production |
WO2020201319A1 (en) * | 2019-04-01 | 2020-10-08 | Université Libre de Bruxelles | 3d printing compositions for modified-release pharmaceutical applications |
ES2828509B2 (en) * | 2019-11-26 | 2022-03-09 | Fund Idonial | COMPOSITION FOR 3D PRINTING OF SEMI-SOLID DRUGS |
CN113925837A (en) * | 2021-09-13 | 2022-01-14 | 四川轻化工大学 | Preparation method of ibuprofen by applying 3D printing technology |
EP4385710A1 (en) * | 2022-12-14 | 2024-06-19 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | An apparatus and a method for sealing an opening in a small tubular vessel |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5449724A (en) * | 1994-12-14 | 1995-09-12 | Xerox Corporation | Stable free radical polymerization process and thermoplastic materials produced therefrom |
WO2016019078A1 (en) * | 2014-07-30 | 2016-02-04 | Tufts University | Three dimensional printing of bio-ink compositions |
WO2016038356A1 (en) * | 2014-09-08 | 2016-03-17 | University Of Central Lancashire | Solid dosage form production |
US20160354315A1 (en) * | 2015-06-03 | 2016-12-08 | Triastek, Inc. | Dosage forms and use thereof |
WO2017158171A1 (en) * | 2016-03-18 | 2017-09-21 | Grünenthal GmbH | Floating pharmaceutical dosage form |
-
2018
- 2018-07-30 WO PCT/IB2018/000974 patent/WO2019025857A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5449724A (en) * | 1994-12-14 | 1995-09-12 | Xerox Corporation | Stable free radical polymerization process and thermoplastic materials produced therefrom |
WO2016019078A1 (en) * | 2014-07-30 | 2016-02-04 | Tufts University | Three dimensional printing of bio-ink compositions |
WO2016038356A1 (en) * | 2014-09-08 | 2016-03-17 | University Of Central Lancashire | Solid dosage form production |
US20160354315A1 (en) * | 2015-06-03 | 2016-12-08 | Triastek, Inc. | Dosage forms and use thereof |
WO2017158171A1 (en) * | 2016-03-18 | 2017-09-21 | Grünenthal GmbH | Floating pharmaceutical dosage form |
Also Published As
Publication number | Publication date |
---|---|
WO2019025857A8 (en) | 2019-06-13 |
WO2019025857A2 (en) | 2019-02-07 |
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