WO2019020807A1 - Anticorps ciblant cd9p-1 et utilisations associées - Google Patents

Anticorps ciblant cd9p-1 et utilisations associées Download PDF

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Publication number
WO2019020807A1
WO2019020807A1 PCT/EP2018/070469 EP2018070469W WO2019020807A1 WO 2019020807 A1 WO2019020807 A1 WO 2019020807A1 EP 2018070469 W EP2018070469 W EP 2018070469W WO 2019020807 A1 WO2019020807 A1 WO 2019020807A1
Authority
WO
WIPO (PCT)
Prior art keywords
cd9p
pathway
targeting antibody
inhibits
stabilin
Prior art date
Application number
PCT/EP2018/070469
Other languages
English (en)
Inventor
Sylvie Colin
Original Assignee
Gene Signal International Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gene Signal International Sa filed Critical Gene Signal International Sa
Priority to CN201880062968.3A priority Critical patent/CN111542538A/zh
Priority to EP18745623.1A priority patent/EP3676291A1/fr
Priority to JP2020526686A priority patent/JP2020528932A/ja
Priority to US16/634,407 priority patent/US20200172618A1/en
Publication of WO2019020807A1 publication Critical patent/WO2019020807A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne une protéine isolée inhibant la voie de CD9P-1, de préférence la voie de CD9P-1/stabiline-1 et/ou la voie de CD9P-1/TRAF-2, en particulier un anticorps isolé contre le CD9P-1 humain, ainsi que son utilisation dans des méthodes thérapeutiques ou diagnostiques.
PCT/EP2018/070469 2017-07-28 2018-07-27 Anticorps ciblant cd9p-1 et utilisations associées WO2019020807A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201880062968.3A CN111542538A (zh) 2017-07-28 2018-07-27 Cd9p-1-靶向抗体及其用途
EP18745623.1A EP3676291A1 (fr) 2017-07-28 2018-07-27 Anticorps ciblant cd9p-1 et utilisations associées
JP2020526686A JP2020528932A (ja) 2017-07-28 2018-07-27 Ｃｄ９ｐ−１標的化抗体およびその使用
US16/634,407 US20200172618A1 (en) 2017-07-28 2018-07-27 Cd9p-1-targeting antibody and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762538106P 2017-07-28 2017-07-28
EP17306017.9 2017-07-28
EP17306017 2017-07-28
US62/538,106 2017-07-28

Publications (1)

Publication Number Publication Date
WO2019020807A1 true WO2019020807A1 (fr) 2019-01-31

Family

ID=59761882

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2018/070469 WO2019020807A1 (fr) 2017-07-28 2018-07-27 Anticorps ciblant cd9p-1 et utilisations associées

Country Status (1)

Country Link
WO (1) WO2019020807A1 (fr)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0404097A2 (fr) 1989-06-22 1990-12-27 BEHRINGWERKE Aktiengesellschaft Récepteurs mono- et oligovalents, bispécifiques et oligospécifiques, ainsi que leur production et application
WO1993011161A1 (fr) 1991-11-25 1993-06-10 Enzon, Inc. Proteines multivalentes de fixation aux antigenes
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US6162963A (en) 1990-01-12 2000-12-19 Abgenix, Inc. Generation of Xenogenetic antibodies
WO2012120125A1 (fr) * 2011-03-09 2012-09-13 Antitope Ltd Anticorps anti-ctla4 humanisés
WO2015121428A1 (fr) 2014-02-14 2015-08-20 Gene Signal International Sa Fragments polypeptidiques de 168a-t2 et compositions les comportant pour utilisation dans le traitement du cancer
WO2017121771A1 (fr) 2016-01-11 2017-07-20 Blink Biomedical Sas Anticorps monoclonaux anti-cd47 humanisés, de souris ou chimériques

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
EP0404097A2 (fr) 1989-06-22 1990-12-27 BEHRINGWERKE Aktiengesellschaft Récepteurs mono- et oligovalents, bispécifiques et oligospécifiques, ainsi que leur production et application
US6162963A (en) 1990-01-12 2000-12-19 Abgenix, Inc. Generation of Xenogenetic antibodies
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
WO1993011161A1 (fr) 1991-11-25 1993-06-10 Enzon, Inc. Proteines multivalentes de fixation aux antigenes
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
WO2012120125A1 (fr) * 2011-03-09 2012-09-13 Antitope Ltd Anticorps anti-ctla4 humanisés
WO2015121428A1 (fr) 2014-02-14 2015-08-20 Gene Signal International Sa Fragments polypeptidiques de 168a-t2 et compositions les comportant pour utilisation dans le traitement du cancer
WO2017121771A1 (fr) 2016-01-11 2017-07-20 Blink Biomedical Sas Anticorps monoclonaux anti-cd47 humanisés, de souris ou chimériques

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* Cited by examiner, † Cited by third party
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