WO2019020511A3 - Procédés de culture améliorés - Google Patents

Procédés de culture améliorés Download PDF

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Publication number
WO2019020511A3
WO2019020511A3 PCT/EP2018/069746 EP2018069746W WO2019020511A3 WO 2019020511 A3 WO2019020511 A3 WO 2019020511A3 EP 2018069746 W EP2018069746 W EP 2018069746W WO 2019020511 A3 WO2019020511 A3 WO 2019020511A3
Authority
WO
WIPO (PCT)
Prior art keywords
culture methods
improved culture
likelihood
reducing
materials
Prior art date
Application number
PCT/EP2018/069746
Other languages
English (en)
Other versions
WO2019020511A2 (fr
Inventor
Alan H HANDYSIDE
Christian OTTOLINI
Michael Summers
Original Assignee
Handyside Alan H
Ottolini Christian
Michael Summers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Handyside Alan H, Ottolini Christian, Michael Summers filed Critical Handyside Alan H
Publication of WO2019020511A2 publication Critical patent/WO2019020511A2/fr
Publication of WO2019020511A3 publication Critical patent/WO2019020511A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0604—Whole embryos; Culture medium therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases (EC 2.)
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/10—Conditioning of cells for in vitro fecondation or nuclear transfer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des procédés et des matériaux de culture qui utilisent des réactifs dans le but de réduire la probabilité d'arrêt du développement d'un embryon humain de préimplantation, par exemple avant la formation des blastocystes.
PCT/EP2018/069746 2017-07-24 2018-07-20 Procédés de culture améliorés WO2019020511A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1711892.8 2017-07-24
GBGB1711892.8A GB201711892D0 (en) 2017-07-27 2017-07-27 Improved culture methods

Publications (2)

Publication Number Publication Date
WO2019020511A2 WO2019020511A2 (fr) 2019-01-31
WO2019020511A3 true WO2019020511A3 (fr) 2019-03-28

Family

ID=59771553

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2018/069746 WO2019020511A2 (fr) 2017-07-24 2018-07-20 Procédés de culture améliorés

Country Status (2)

Country Link
GB (1) GB201711892D0 (fr)
WO (1) WO2019020511A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070006332A1 (en) * 2003-08-20 2007-01-04 Northern Sydney Area Health Service Methods for enhancing embryo viability
US20160138105A1 (en) * 2014-11-14 2016-05-19 The Board Of Trustees Of The Leland Stanford Junior University System and methods for determining a woman's risk of aneuploid conception
WO2016166604A1 (fr) * 2015-04-17 2016-10-20 Ludwig Institute For Cancer Research Ltd Inhibiteurs de plk4

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070006332A1 (en) * 2003-08-20 2007-01-04 Northern Sydney Area Health Service Methods for enhancing embryo viability
US20160138105A1 (en) * 2014-11-14 2016-05-19 The Board Of Trustees Of The Leland Stanford Junior University System and methods for determining a woman's risk of aneuploid conception
WO2016166604A1 (fr) * 2015-04-17 2016-10-20 Ludwig Institute For Cancer Research Ltd Inhibiteurs de plk4

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
OLCHA M ET AL: "The PLK4 locus is not associated with human embryonic aneuploidy risk", FERTILITY AND STERILITY, vol. 104, no. 3, 20 October 2015 (2015-10-20), XP029273518, ISSN: 0015-0282, DOI: 10.1016/J.FERTNSTERT.2015.07.160 *
QIAN ZHANG ET AL: "Maternal common variant rs2305957 spanning PLK4 is associated with blastocyst formation and early recurrent miscarriage", FERTILITY AND STERILITY., vol. 107, no. 4, 1 April 2017 (2017-04-01), USA, pages 1034 - 1040.e5, XP055509030, ISSN: 0015-0282, DOI: 10.1016/j.fertnstert.2017.01.006 *
R. C. MCCOY ET AL: "Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos", SCIENCE, vol. 348, no. 6231, 9 April 2015 (2015-04-09), US, pages 235 - 238, XP055509118, ISSN: 0036-8075, DOI: 10.1126/science.aaa3337 *
RAJIV C MCCOY ET AL: "Tripolar chromosome segregation drives the association between maternal genotype at variants spanning PLK4 and aneuploidy in human preimplantation embryos", HUMAN MOLECULAR GENETICS, vol. 27, no. 14, 15 July 2018 (2018-07-15), gb, pages 2573 - 2585, XP055509020, ISSN: 0964-6906, DOI: 10.1093/hmg/ddy147 *

Also Published As

Publication number Publication date
WO2019020511A2 (fr) 2019-01-31
GB201711892D0 (en) 2017-09-06

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