WO2019003245A1 - Dispositif d'imagerie optique multispectrale et procédé d'imagerie fonctionnelle de la peau sans contact - Google Patents

Dispositif d'imagerie optique multispectrale et procédé d'imagerie fonctionnelle de la peau sans contact Download PDF

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Publication number
WO2019003245A1
WO2019003245A1 PCT/IN2018/050418 IN2018050418W WO2019003245A1 WO 2019003245 A1 WO2019003245 A1 WO 2019003245A1 IN 2018050418 W IN2018050418 W IN 2018050418W WO 2019003245 A1 WO2019003245 A1 WO 2019003245A1
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WO
WIPO (PCT)
Prior art keywords
user
multispectral
server
images
imaging
Prior art date
Application number
PCT/IN2018/050418
Other languages
English (en)
Inventor
Sheet DEBDOOT
Basak KAUSIK
Ojha TAMOGHNA
Karri Phani KRISHNA
Original Assignee
Skincurate Research Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Skincurate Research Private Limited filed Critical Skincurate Research Private Limited
Publication of WO2019003245A1 publication Critical patent/WO2019003245A1/fr

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6887—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices
    • A61B5/6898—Portable consumer electronic devices, e.g. music players, telephones, tablet computers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Definitions

  • the present invention relates to an optical imaging device and associated hardware- software co-designed technology.
  • the present invention aims at noninvasive, contactless, point-of-care and real-time functional imaging of skin conditions for screening, early diagnosis, monitoring and prognosis and a method for the same.
  • Dermatoscopy utilizes the use of dermatoscope for examining skin lesions and has a low diagnostic specificity of current screening. These are usually in the form of a handheld device or a smart phone attachment and assist in screening of skin lesions. Some generations of dermatoscope can only capture high resolution images with improved optics and illumination, thus limited to only doctors or clinicians for screening of skin lesions. Other generations come with an attachment to smart phones with hardware and software co-designed platform, thereby facilitating the transfer of the images to neighborhood doctors for screening and clinical inference.
  • Histopathology is the microscopic examination of biological tissue. It suffers from trauma associated with invasive biopsy and prolonged period of intervention. Often, it may lead to psychiatric disorders which hamper their healing process. It is a three stage process involving biopsy of the wound tissue, followed by its biochemical processing and histological depiction for standardized clinical reporting. Although it quantifies the tissue involvement in a wound from its surface to its depth, it lacks in the context of being an invasive, ex vivo and time consuming procedure.
  • constellation Another technique known as constellation which provides a cost-effective and fast scanning of skin moles for early detection of skin cancer.
  • the process involves digital imaging of moles and stitching of images, followed by transmission of images over cloud.
  • a graphical modelling based algorithm, working on the cloud, will analyze the changes of skin moles over time.
  • WO2014190091A1 relates to a system and method for imaging a patient user's body part is disclosed.
  • the method may include selecting an optical imaging device to image the patient user's body part, acquiring one or more data sets with the optical imaging device, the acquiring is performed with focus at multiple axial positions and exposure control or deliberate focus at specified image locations and exposure control, registering the acquired data sets, performing image processing on the acquired data sets and recombining good data from the image processed data sets into a single image of the patient user's body parts.
  • the main object of the present invention is to overcome the limitations of the prior art.
  • An object of the present invention is to provide a portable and hand-held multispectral optical imaging device and a method for noninvasive and real-time functional imaging of skin conditions with limited user expertise for screening, early diagnosis, monitoring and prognosis.
  • Another object of the present invention is to provide device that can be used as a hardware attachment over smart phone devices or used as a standalone device.
  • Another object of the present invention is to provide a device that employs physics of tissue photon interaction and advance machine learning techniques for analysis of captured multispectral images for precise screening.
  • Another object of the present invention is to provide a device that tracks the changes of the skin conditions along the timeline.
  • Yet another object of the present invention is to provide a device that delivers point-of-care diagnostics without the need of undertaking invasive biopsy.
  • Yet another object of the present invention is to provide a device that enables high-precision and high through-put screening results of different skin conditions and facilitates periodic monitoring and prognostic inference of different skin abnormalities.
  • the present invention is envisioned towards a portable and hand-held multispectral optical imaging device (as a smartphone attachment or a standalone device) for noninvasive and real-time functional imaging of skin conditions with limited user expertise for screening, early diagnosis and monitoring.
  • the optical imaging device comprises of at least one LED based structured multispectral illumination system; a driver circuit to trigger the LEDs at different spectrum of illumination; a user based platform/interface distributed over cloud to facilitate the communication between device and the user and a computational imaging server for processing images according to the user's requirement and transferring the inferences back to the user's device.
  • the method of operation of said device comprises the steps of; actuating the camera by the user platform/interface on a smartphone or the imaging sensor on the standalone device for image acquisition; transferring acquired multispectral images to a cloud based computational imaging server for processing of said images; and transferring back clinical inference to the device for clinical assistance and future references.
  • Figure 1 illustrates a schematic representation of the device along with the components, according to an exemplary embodiment of the present invention.
  • the device that can be used as a hardware attachment over smart-phone devices or used as standalone device.
  • the optical imaging device comprises of at least one LED based structured multispectral illumination system; a driver circuit to trigger the LEDs at different spectrum of illumination; a user based platform/interface distributed over cloud to facilitate the communication between device and the user and a computational imaging server for processing images according to the user's requirement and transferring the inferences back to the user's device.
  • Figure 1 illustrates the schematic representation of the product which is a combination of a Smartphone and Multispectral Structured Illumination(MSI) hardware to generate Multispectral Image Sequence Acquisition.
  • MSI Multispectral Structured Illumination
  • the method of operation of said device comprises the steps of; actuating the camera by the user platform/interface on a smart-phone or the imaging sensor on the standalone device for image acquisition; transferring acquired multispectral images to a cloud based computational imaging server for processing of said images; and transferring back clinical inference to the device for clinical assistance and future reference.
  • the present invention is basically a hardware-software co-designed system for low-cost, non-invasive, real-time and contactless multispectral imaging through machine learning techniques to enable patient comfort centric and in situ functional characterization of skin tissue.
  • a statistical learner is modeled based on the physics of tissue photon interaction in multiple wavelength regimes of the multi spectral images of skin.
  • the device is associated with computational software services distributed over cloud that provides a complete suite of image based diagnosis.
  • the computational imaging server also maintains record of the user's images and re-processes them over time for patient centric tractability and diagnosis.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Business, Economics & Management (AREA)
  • General Business, Economics & Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dermatology (AREA)
  • Multimedia (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

La présente invention concerne un dispositif d'imagerie optique multispectrale, comprenant : un système d'éclairage multispectral structuré à base de LED ; un circuit d'attaque qui déclenche une pluralité de LED à un spectre d'éclairage différent ; une plateforme/interface basée sur l'utilisateur distribuée sur un nuage qui facilite la communication entre ledit dispositif et l'utilisateur ; et un serveur d'imagerie informatique qui traite les images selon les besoins du serveur et retransfère les inférences au dispositif. Le procédé de fonctionnement comprend les étapes d'actionnement d'une caméra par la plateforme/interface utilisateur sur smartphone ou le capteur d'imagerie sur le dispositif autonome d'acquisition d'images ; de transfert des images multispectrales acquises à un serveur d'imagerie informatique en nuage pour le traitement des images ; et le retransfert des inférences cliniques vers le dispositif à des fins d'assistance clinique et de référence future.
PCT/IN2018/050418 2017-06-28 2018-06-26 Dispositif d'imagerie optique multispectrale et procédé d'imagerie fonctionnelle de la peau sans contact WO2019003245A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201731022695 2017-06-28
IN201731022695 2017-06-28

Publications (1)

Publication Number Publication Date
WO2019003245A1 true WO2019003245A1 (fr) 2019-01-03

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11883128B2 (en) 2016-08-24 2024-01-30 Mimosa Diagnostics Inc. Multispectral mobile tissue assessment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008111994A1 (fr) * 2006-07-19 2008-09-18 Lumidigm, Inc. Capteurs biométriques spectraux
WO2016069788A1 (fr) * 2014-10-29 2016-05-06 Spectral Md, Inc. Procédés d'imagerie optique multispectrale, à résolution temporelle, en mode réflectif et appareils de classification de tissus
WO2017074505A1 (fr) * 2015-10-28 2017-05-04 Spectral Md, Inc. Procédés d'imagerie optique multispectrale, à résolution temporelle, en mode réflectif et appareils de classification de tissus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008111994A1 (fr) * 2006-07-19 2008-09-18 Lumidigm, Inc. Capteurs biométriques spectraux
WO2016069788A1 (fr) * 2014-10-29 2016-05-06 Spectral Md, Inc. Procédés d'imagerie optique multispectrale, à résolution temporelle, en mode réflectif et appareils de classification de tissus
WO2017074505A1 (fr) * 2015-10-28 2017-05-04 Spectral Md, Inc. Procédés d'imagerie optique multispectrale, à résolution temporelle, en mode réflectif et appareils de classification de tissus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11883128B2 (en) 2016-08-24 2024-01-30 Mimosa Diagnostics Inc. Multispectral mobile tissue assessment

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