WO2019000847A1

WO2019000847A1 - Fixing key for chromatography column

Info

Publication number: WO2019000847A1
Application number: PCT/CN2017/114919
Authority: WO
Inventors: 王正涛; 严忠; 尤慧艳; 范大双; 居延娟; 李枝玲; 沈健增; 张大兵
Original assignee: 江苏汉邦科技有限公司
Priority date: 2017-06-27
Filing date: 2017-12-07
Publication date: 2019-01-03
Also published as: CN107116503A

Abstract

A fixing key for a chromatography column consists of a tensioning assembly (13) and a connection sleeve assembly (12). The tensioning assembly comprises a screw bolt (8), a tensioning sleeve (9), a tensioning pin (10), a milled flat member (15), and a slot (16). The connection sleeve assembly consists of a connection sleeve (6), a protruding member (7), and a handle (5). The protruding member is disposed at a lower end of the connection sleeve assembly and is inserted into a hole (11) at an upper end of the tensioning sleeve to form a special-purpose fixing key for a chromatography column. By using the above fixing key, no hole or recess needs to be formed at a surface of a frit ferrule (1), such that when in contact with a sample and a mobile phase, there are no dead angles, such that the surface of the frit ferrule can be cleaned easily. Moreover, the fixing key can be directly used above a frit without having to be positioned under an end cap of a chromatography column, thereby removing limitations on an overall height of the chromatography column, and reducing production costs.

Description

Wrench for chromatography column

Technical field

The invention relates to a special wrench for a chromatography column, belonging to the field of industrial preparative chromatography.

Background technique

The column is an important equipment for separating the desired target material from a complex liquid system. It consists of a cylinder, a piston, a filter plate, a distributor, an end cap, etc., wherein the filter plate and the distributor are important components. In the structural design and processing of the column, it is necessary to fix the two together. The existing fixing mainly has two structural forms: the first one is to have several small holes or small grooves on the upper surface of the sieve plate pressing ring. The special wrench is stuck in the small hole or small groove to lock the filter plate and the distributor (see Figure 1); the second is to use the pressure ring nut to press the sieve ring, the filter plate and the distributor lock from the lower part of the end cover Tight (see Figure 2). In the first structure, although the locking is convenient, the small holes or grooves on the surface of the pressure ring of the sieve plate are directly in contact with the sample or the mobile phase, and it is difficult to clean; the second structure is easy to clean, but the locking is very inconvenient, not only The relevant parts are removed and a large space is left under the end caps for easy access and the overall height of the column needs to be lengthened.

Summary of the invention

In order to solve the technical problem that the chromatographic sieve plate and the dispenser are inconvenient to lock and difficult to clean, the present invention provides a special wrench for a chromatography column, and the specific technical solutions are as follows:

A wrench for a chromatography column, comprising a tensioning assembly and a connecting sleeve assembly; the tensioning assembly comprises a screw, a tensioning sleeve, a tensioning pin, a milling flat, a groove; the lower end of the tensioning sleeve is an inner conical surface, on which There are several slots in the upper part, the upper end cylinder is set to be flattened, and the outer side of the milling flat is provided with a plurality of small holes. The tension pin is located at the lower end of the tension sleeve, and the upper part is provided with an outer conical surface, and the screw is passed through the tension sleeve to rise. The locking sleeve is composed of a connecting sleeve, a boss and a handle. The connecting sleeve is located above the boss, and the handle is inserted in the connecting sleeve; the lower end of the connecting sleeve assembly is inserted into the upper end of the tensioning sleeve to form a tom Special wrench for the column.

Preferably, the handle is movable left and right in the connecting sleeve.

The invention has the following advantages: (1) no punching or slotting on the surface of the screen ring, no dead angle when contacting the sample and the mobile phase, easy to clean; (2) the wrench is directly used above the sieve plate, without entering the column Operating under the end cap, the overall height of the column is not limited, saving production costs.

DRAWINGS

Figure 1 is a first type of sieve plate pressing structure of the prior art

2 is a second type of sieve plate pressing structure of the prior art

3 is a schematic structural view of a wrench of the present invention

4 is a schematic structural view of a connecting sleeve assembly of the present invention

Figure 5 is a schematic view showing the structure of the tensioning assembly of the present invention

Figure 6 is a perspective view of the tension sleeve in the tensioning assembly of the present invention

Figure 7 is a schematic view showing the structure of the tension sleeve assembly of the present invention inserted into the pressure ring of the sieve plate

Figure 8 is a schematic view showing the structure of the present invention in use.

The specific code in the figure is as follows: 1. sieve plate pressure ring 2. sieve plate 3. distributor 4. pressure ring nut 5. handle 6. connection sleeve 7. boss 8. screw 9. tension sleeve 10. tension pin 11 Small hole 12. Connecting sleeve assembly 13. Tensioning assembly 14. Sealing ring 15. Milling 16. Slot.

Detailed ways

The present invention will be further described in detail below with reference to FIGS. 3 to 8. The invention consists of a tensioning assembly 13 and a connecting sleeve assembly 12; the tensioning assembly 13 comprises a screw 8, a tensioning sleeve 9, a tensioning pin 10, a milling flat 15, a slot 16; the lower end of the tensioning sleeve 9 is an inner conical surface, There are a plurality of slots 16 in the upper part, a milling flat 15 is arranged on the upper end cylinder, and a plurality of small holes 11 are arranged on the outer side of the milling flat 15 . The tension pin 10 is located at the lower end of the tension sleeve 9 and has an outer conical surface on the upper portion thereof, with screws 8 through the tensioning sleeve 9 to lock the tension pin 10; the connecting sleeve assembly 12 is composed of a connecting sleeve 6, a boss 7, a handle 5, the connecting sleeve 6 is located above the boss 7, the handle 5 is inserted in the connecting sleeve 6; The lower end boss 7 of the connecting sleeve assembly 12 is inserted into the small hole 11 at the upper end of the tensioning sleeve 9 to form a special wrench for the column, wherein the handle 5 can be moved left and right in the connecting sleeve 6.

When in use, the screw 8 on the tensioning assembly 13 is loosened, the tension pin 10 is moved down, the tensioning sleeve 9 is reduced, and the reduced tensioning assembly 13 is inserted into the hole in the center of the sieve plate pressing ring 1 with a universal The wrench sleeve is screwed on the milling flat 15 at the upper end of the tension sleeve 9 and the other wrench is used to tighten the screw 8. The tension pin 10 is moved upwards, and the outer tapered surface supports the inner conical surface of the tension sleeve 9 to tighten the sleeve. The outer diameter of 9 becomes larger, and the inner hole of the pressure ring 1 of the sieve plate is tightened, and the two sides cannot rotate relative to each other. At this time, the lower end surface of the tension sleeve 9 is higher than the sealing ring 14 without being bitten (Fig. 7), insert the boss 7 at the lower end of the connecting sleeve assembly 12 into the small hole 11 on the surface of the tensioning assembly 13, rotate the handle 5 (Fig. 8), tighten the screen pressing ring 1, and take out the connecting sleeve assembly 12, which will rise. The screw 8 on the tight assembly 13 is loosened, the tension pin 10 is moved down, the tension sleeve 9 is contracted, and the tensioning assembly 13 is pulled out from the hole in the center of the sieve plate pressing ring 1, that is, the sieve plate 2 and the distributor 3 are completed. Fixed.

Claims

A wrench for a chromatography column, characterized by: a tensioning assembly (13) and a connecting sleeve assembly (12); the tensioning assembly (13) comprises a screw (8), a tension sleeve (9), and a riser Tightening pin (10), milling flat (15), groove (16); the lower end of the tensioning sleeve (9) is an inner conical surface, which has a plurality of slots (16), and the upper end cylinder is provided with a flattening (15). There are several small holes (11) on the outer side of the milling flat (15). The tension pin (10) is located at the lower end of the tension sleeve (9), and an upper conical surface is arranged on the upper part thereof, and the tension sleeve is passed through the screw sleeve (8). (9) Locking the tension pin (10); the connecting sleeve assembly (12) is composed of a connecting sleeve (6), a boss (7), a handle (5), and the connecting sleeve (6) is located above the boss (7) The handle (5) is inserted into the connecting sleeve (6); the lower end boss (7) of the connecting sleeve assembly (12) is inserted into the special wrench of the column formed in the small hole (11) of the upper end of the tensioning sleeve (9).
A wrench for a chromatography column according to claim 1, characterized in that the handle (5) is movable left and right in the connecting sleeve (6).