WO2018222779A1 - Systems and methods for constructing a synthetic anatomical model with predetermined anatomic, biomechanical, and physiological properties - Google Patents
Systems and methods for constructing a synthetic anatomical model with predetermined anatomic, biomechanical, and physiological properties Download PDFInfo
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- WO2018222779A1 WO2018222779A1 PCT/US2018/035223 US2018035223W WO2018222779A1 WO 2018222779 A1 WO2018222779 A1 WO 2018222779A1 US 2018035223 W US2018035223 W US 2018035223W WO 2018222779 A1 WO2018222779 A1 WO 2018222779A1
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- synthetic
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- printing
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- synthetic model
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Classifications
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Definitions
- FIG. 22 is an image demonstrating synthetic 3D printed psoas muscle with nerve roots running through it.
- FIG. 25 is an image demonstrating synthetic ligamentum flavum integrated into a model.
- anatomical components may be constructed and may include synthetic blood vessels, a synthetic thecal sac, synthetic muscle, and synthetic periosteum, and other synthetic mimics of anatomical components in addition to the 3D printed synthetic model, as further described herein.
- a system for configuring an apparatus comprising a three-dimensional printer and computing device to construct a synthetic anatomical model with specific predefined anatomic, biomechanical, and physiological properties is illustrated and generally indicated as 100 in FIGS. 1 -27.
- the user may decide what information is relevant to generate the desired synthetic anatomical model 116, such as a component that contains vascular anatomy, or artificial neural elements capable of conducting electricity, or any standard healthy anatomy or any number of patient-specific disease states, with, e.g. , anatomical and biomechanical fidelity to that healthy or diseased-state.
- a component that contains vascular anatomy, or artificial neural elements capable of conducting electricity or any standard healthy anatomy or any number of patient-specific disease states, with, e.g. , anatomical and biomechanical fidelity to that healthy or diseased-state.
- additional synthetic components may be constructed which may be integrated with the synthetic anatomical model 116, or separately formed/used (as described herein) for different applications during a post processing step 150 or stage.
- the additional synthetic components formed during a post-processing step 150 may include a synthetic thecal sac, blood vessels, nerve roots, various types of soft tissue, synthetic dermis, subcutaneous adipose tissue, paraspinal muscles, and supportive ligament structures of the spine or other components.
- FIGS. 12-13 demonstrate the shell and in-fill of a vertebral body model (FIG. 12), and how this structure mimics the cortiocancellous architecture of human bone when viewed under fluoroscopy (FIG. 13). It was discovered that both the shell and the in-fill can be modified to print at various thicknesses and densities. The in-fill can furthermore be modified to be printed in one of several different patterns, including hexagonal, diamond, and linear.
- the print temperature was held at 230°C, the print bed temperature at 30°C, the print resolution at 0.2 mm, and the print speed at 60 mm/s.
- the print temperature was held at 230°C, the print bed temperature at 50°C, the print resolution at 0.2 mm, and the print speed at 30 mm/s.
- the synthetic anatomical model 116 may further include an artificial soft tissue layer, illustrated as soft tissue layer 524 of FIG. 18, overlaying the synthetic model such that the synthetic anatomical model 116 is completely or partially disposed within the artificial soft tissue layer 524.
- the artificial soft tissue layer 524 may include e.g., Styrofoam, or may be comprised out of any material or substance suitable for the tester's preference without departing from the scope of this disclosure.
- the soft tissue layer 524 may be comprised of some flexible or inflexible material such as a silicone, rubber, elastomeric polymer, foam, or combinations thereof.
- the underlying thecal sac is punctured during the test, internal pressure from the synthetic anatomical model 116 will force the liquid solution through the punctured portion of the model where it will be visible by the surgeon; the surgeon may then practice repairing the thecal sac 532 in accordance with general durotomy procedures.
- the thecal sac 532 can also contain certain materials that mimic the spinal cord and/ or nerve roots, to increase the face validity of the synthetic model as a surgical training platform.
- thecal sac 532 described may be configured to attach to the synthetic anatomical model 116 by any mechanism or structure or by any method or process suitable for, and capable of, maintaining or securing the thecal sac 532 in a desired position.
- the component may be printed directly into the subject's anatomy without departing from the scope of the disclosure. It is also contemplated that the printed or artificial anatomical components of the present inventive concept are capable of biodegradation, bioabsorbtion, or both, whether it is being used as a temporary implant, or for another purpose suitable for the user's needs.
- the synthetic anatomical model 116 may be constructed out of a degradable or absorbable material such that it may act as a temporary support structure in the subject's body, thereby improving biomechanical stability of other constructs.
- the synthetic anatomical model 116 could be printed to include or carry biological agents such as bone graft extenders, bone morphogenic proteins, or other suitable agents.
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Priority Applications (8)
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EP18809330.6A EP3565719B1 (en) | 2017-05-30 | 2018-05-30 | Systems and methods for constructing a synthetic anatomical model with predetermined anatomic, biomechanical, and physiological properties |
JP2019544677A JP7092781B2 (en) | 2017-05-30 | 2018-05-30 | Systems and methods for building synthetic anatomical models with given anatomical, biomechanical, and physiological properties |
KR1020197038584A KR102276750B1 (en) | 2017-05-30 | 2018-05-30 | Systems and methods for building a synthetic anatomical model with predetermined anatomical, biomechanical, and physiological properties |
CN201880024117.XA CN110546004B (en) | 2017-05-30 | 2018-05-30 | Method for constructing a synthetic anatomical model having predetermined anatomical, biomechanical and physiological properties |
AU2018275541A AU2018275541B2 (en) | 2017-05-30 | 2018-05-30 | Systems and methods for constructing a synthetic anatomical model with predetermined anatomic, biomechanical, and physiological properties |
CA3054639A CA3054639C (en) | 2017-05-30 | 2018-05-30 | Systems and methods for constructing a synthetic anatomical model with predetermined anatomic, biomechanical, and physiological properties |
US16/943,907 US11033336B2 (en) | 2017-05-30 | 2020-07-30 | Systems and methods for constructing a synthetic anatomical model with predetermined anatomic, biomechanical, and physiological properties |
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KR20200016290A (en) | 2020-02-14 |
CA3054639A1 (en) | 2018-12-06 |
CN110546004A (en) | 2019-12-06 |
AU2018275541B2 (en) | 2019-11-07 |
EP3565719A1 (en) | 2019-11-13 |
AU2018275541A1 (en) | 2019-09-19 |
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US20200078093A1 (en) | 2020-03-12 |
CA3054639C (en) | 2023-09-19 |
EP3565719A4 (en) | 2020-01-15 |
JP2020522398A (en) | 2020-07-30 |
CN110546004B (en) | 2021-07-20 |
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