WO2018220926A1 - Microneedle patch and packing material for same - Google Patents

Microneedle patch and packing material for same Download PDF

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Publication number
WO2018220926A1
WO2018220926A1 PCT/JP2018/007639 JP2018007639W WO2018220926A1 WO 2018220926 A1 WO2018220926 A1 WO 2018220926A1 JP 2018007639 W JP2018007639 W JP 2018007639W WO 2018220926 A1 WO2018220926 A1 WO 2018220926A1
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WO
WIPO (PCT)
Prior art keywords
sheet
oil gel
microneedle patch
gel sheet
microneedles
Prior art date
Application number
PCT/JP2018/007639
Other languages
French (fr)
Japanese (ja)
Inventor
佐知 永井
紗央里 吉塚
喜子 末冨
夕佳 三浦
Original Assignee
Ｎｉｓｓｈａ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ｎｉｓｓｈａ株式会社 filed Critical Ｎｉｓｓｈａ株式会社
Priority to JP2018539447A priority Critical patent/JP6968805B2/en
Priority to KR1020187031590A priority patent/KR102547455B1/en
Priority to CN201880002161.0A priority patent/CN109328086B/en
Publication of WO2018220926A1 publication Critical patent/WO2018220926A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/06—Packaging for specific medical equipment

Definitions

  • the present invention relates to a microneedle patch and its package.
  • the microneedle sheet has a plurality of microneedles formed on a sheet-like substrate.
  • a microneedle By inserting a microneedle into the skin, administration of a target substance contained in the microneedle becomes possible.
  • Patent Document 1 discloses a microneedle patch 20 in which an adhesive sheet 26 is provided on the back surface of the microneedle sheet 23 in order to fix the microneedle sheet 23 to the skin (see FIG. 12). Since the microneedle sheet 23 is not formed around the adhesive sheet 26, the microneedle sheet 23 can be fixed to the skin by the adhesive layer 24 around the adhesive sheet 26.
  • the conventional microneedle patch disclosed in Patent Document 1 has a problem in that a cosmetic effect cannot be obtained from the portion of the adhesive layer that is attached to the skin.
  • the conventional microneedle patch is applied to the skin to which the emulsion or cream (hereinafter referred to as emulsion) is applied, the adhesive force of the adhesive layer 24 is weakened by the fats and oils contained in the emulsion and the like, so that it easily peels off. There was a problem.
  • the present invention has been made in order to solve this problem, a microneedle patch that can obtain a cosmetic effect from a portion that is affixed to the skin, and that does not easily peel off even when affixed to the skin to which an emulsion or the like is applied.
  • An object of the present invention is to provide a package of such a microneedle patch.
  • the microneedle patch of the present invention includes an oil gel sheet and a plurality of microneedles formed in a region excluding the peripheral portion of the oil gel sheet.
  • a sheet-like substrate may be further provided in a region between the oil gel sheet and the plurality of microneedles where the plurality of microneedles are formed.
  • an adhesive layer may be further provided on the surface of the plurality of microneedles facing the oil gel sheet.
  • an adhesive layer may be further provided on the surface of the sheet-like substrate facing the oil gel sheet.
  • the microneedle patch package of the present invention comprises an oil gel sheet and a plurality of microneedles formed in a region excluding the peripheral portion of the oil gel sheet and having an adhesive layer formed on a surface facing the oil gel sheet.
  • a patch and a storage sheet that covers a peripheral portion of the oil gel sheet and includes a storage portion in which a plurality of micro concave portions are formed and a plurality of micro needles are stored.
  • the package of the microneedle patch of the present invention is an oil gel sheet, an adhesive layer formed in a region excluding the peripheral part of the oil gel sheet, and a sheet formed on the adhesive layer in the same shape as the adhesive layer
  • a microneedle patch having a base and a plurality of microneedles formed on the sheet-like base, and a storage portion that covers the periphery of the oil gel sheet and that has a plurality of microrecesses and that stores a plurality of microneedles And a storage sheet having.
  • the microneedle patch of the present invention was configured to include an oil gel sheet and a plurality of microneedles formed in a region excluding the peripheral portion of the oil gel sheet. Therefore, according to the present invention, it is possible to provide a cosmetic effect even from a portion attached to the skin, and it is possible to provide a microneedle patch that does not easily peel off even when applied to the skin to which an emulsion or the like is applied.
  • the microneedle patch package of the present invention comprises an oil gel sheet and a plurality of microneedles formed in a region excluding the peripheral portion of the oil gel sheet and having an adhesive layer formed on a surface facing the oil gel sheet.
  • a patch and a storage sheet that covers a peripheral portion of the oil gel sheet and includes a storage portion in which a plurality of micro concave portions are formed and a plurality of micro needles are stored are provided. Therefore, according to the present invention, it is possible to provide a cosmetic effect from a portion attached to the skin, and it is possible to provide a package of microneedle patches that do not easily peel off even when applied to the skin to which an emulsion or the like is applied.
  • the package of the microneedle patch of the present invention is an oil gel sheet, an adhesive layer formed in a region excluding the peripheral part of the oil gel sheet, and a sheet formed on the adhesive layer in the same shape as the adhesive layer
  • a microneedle patch having a base and a plurality of microneedles formed on the sheet-like base, and a storage portion that covers the periphery of the oil gel sheet and that has a plurality of microrecesses and that stores a plurality of microneedles And a storage sheet having the structure.
  • the present invention it is possible to provide a cosmetic effect from a portion attached to the skin, and it is possible to provide a package of microneedle patches that do not easily peel off even when applied to the skin to which an emulsion or the like is applied.
  • (A) It is a typical perspective view which shows one Embodiment of the microneedle patch of this invention.
  • (B) It is AA sectional drawing of (a). It is typical sectional drawing which shows an example of the manufacturing method of the microneedle patch of this invention. It is typical sectional drawing which shows an example of the manufacturing method of the microneedle patch of this invention. It is typical sectional drawing which shows the modification of the microneedle patch of this invention. It is typical sectional drawing which shows an example of the manufacturing method which concerns on the modification of the microneedle patch of this invention. It is typical sectional drawing which shows one Embodiment of the package body of the microneedle patch of this invention.
  • the microneedle patch 1 of the present invention includes an oil gel sheet 3 and a plurality of microneedles 2 formed in a region excluding the peripheral portion 3a of the oil gel sheet 3 (FIGS. 1A and 1B). )reference).
  • the oil gel sheet 3 is a sheet in which an oil gel is formed on a support.
  • a material such as a nonwoven fabric or a woven fabric can be used as the support.
  • the oil gel is a gel containing an oil-soluble component and has good adhesiveness to the skin.
  • the oil-soluble component is not particularly limited as long as it can permeate into the skin after being applied to the skin and give a cosmetic effect. Examples of such components include oil-soluble vitamin C derivatives, retinol derivatives, astaxanthin, squalane, plant-derived oil, ceramide (sphingolipid), tocopherol (vitamin E), and the like.
  • the microneedles 2 are formed in a region excluding the peripheral portion 3 a of the oil gel sheet 3. Therefore, after the microneedle 2 is stabbed into the skin, the microneedle patch 1 can be brought into close contact with the skin by the peripheral portion 3a of the oil gel sheet 3.
  • the microneedles 2 can be, for example, conical, pyramidal, frustoconical, and conical.
  • the coneide shape represents a shape in which a side surface of a cone shape or a truncated cone shape is curved inward.
  • the protruding height of the microneedles 2 from the oil gel sheet 3 can be, for example, not less than 10 ⁇ m and not more than 500 ⁇ m.
  • the density of the microneedles 2 can be, for example, 100 / cm 2 or more and 500 / cm 2 or less.
  • the microneedle 2 may be formed of a material that the microneedle itself dissolves in the skin after piercing the skin, or may be formed of a material that does not dissolve.
  • materials that dissolve in the skin include water-soluble polymers such as hyaluronic acid, chondroitin sulfate, collagen, gelatin, glycogen, dextran, dextrin, chitosan, proteoglycan, pullulan, carboxymethylcellulose, polyvinyl alcohol, and carboxyvinyl polymer. be able to. These water-soluble polymers may be used alone or in combination of two or more. In addition, a water-soluble cosmetic ingredient may be added to these water-soluble polymers.
  • the water-soluble polymer When a microneedle is stabbed into the skin, the water-soluble polymer is dissolved by the moisture of the skin.
  • the skin can be moisturized by the nature of the water-soluble polymer itself or the added cosmetic ingredient.
  • a resin or a metal can be used as a material that does not dissolve in the skin.
  • a water-soluble cosmetic component having a moisturizing effect may be coated on the surface of the microneedles.
  • the cosmetic ingredients dissolve in the skin, and the skin can be moisturized.
  • the microneedle patch 1 of the present invention is brought into close contact with the skin by an oil gel sheet 3 containing cosmetic ingredients. Therefore, in addition to the microneedles 2, a cosmetic effect can be obtained from the peripheral portion 3a of the oil gel sheet 3 attached to the skin.
  • the oil gel sheet 3 has high adhesiveness and can be adhered and pasted, but when the microneedle patch 1 is peeled off, the keratin is hardly peeled off and the safety is high.
  • the microneedle patch of the present invention uses an oil gel sheet, even when the microneedle is formed of a water-soluble polymer, the shape of the microneedle is maintained until immediately before the microneedle patch is applied to the skin. can do. Therefore, it is not necessary for the user to combine the micro needle and the oil gel sheet immediately before use.
  • the microneedle patch 1 of the present invention uses the oil gel sheet 3, it can be applied to the skin to which an emulsion or the like is applied, and is difficult to peel off even after being applied. This is because the oil contained in the oil gel sheet 3 and the fats and oils contained in the emulsion are easily compatible. For the same reason as described above, it can be applied even to skin with a large amount of sebum secretion, and a microneedle patch that does not easily peel off even after being applied can be obtained.
  • the microneedle patch of the present invention can be manufactured by a conventionally known method.
  • a mold 10 having a plurality of recesses 10a is prepared (see FIG. 2A).
  • a resin sheet, a metal, or the like can be used.
  • a method for forming the recess in the case of a resin sheet, a method of pressing a stamper having the same shape as that of the microneedle against the resin sheet may be used.
  • metal a method such as cutting or electric discharge machining may be used.
  • the concave portion is filled with the raw material liquid 2a (see FIG. 2B).
  • a filling method a method using a known device such as an inkjet, a dispenser, a dispenser, or a squeegee can be used.
  • the oil gel sheet 3 is bonded to the bottom surface of the micro needle 2 (see FIG. 2C).
  • the microneedle patch 1 is peeled from the mold (see FIG. 2 (d)).
  • the following manufacturing method can also be used.
  • the raw material liquid 2a is dropped and adhered onto the oil gel sheet 3 (see FIG. 3A)
  • the plate 11 is brought closer to the plate 11 from the direction facing the surface to which the raw material liquid 2a is adhered, and the raw material liquid 10a is applied to the plate 11.
  • Contact is made (see FIG. 3B).
  • the plate 11 is gradually separated from the oil gel sheet 3 in a state parallel to the oil gel sheet 3 to form a plurality of microneedles 2 (see FIG. 3C). Therefore, it is preferable that the raw material liquid 2a has a viscosity enough to pull the yarn when the plate 11 is pulled away.
  • a solvent a medium in which a water-soluble polymer is soluble in addition to water can be selected.
  • the resin or metal can be formed by cutting it into the shape of a microneedle.
  • it should have a truncated cone shape that does not pierce the skin. If it does in this way, it can prevent that metal microneedles remain in skin, and can improve the safety of a microneedle patch.
  • the shape of the microneedle can be maintained during the production of the microneedle patch even when the microneedle is formed of a water-soluble polymer. .
  • the microneedle patch 1 which concerns on the modification of the said embodiment is demonstrated.
  • the microneedle patch 1 according to the modified example further includes a sheet-like substrate 4 in a region between the oil gel sheet 3 and the plurality of microneedles 2 where the plurality of microneedles 2 are formed (FIG. 4). reference).
  • the sheet-like substrate 4 is formed in a region where a plurality of microneedles 2 are formed. Since the plurality of microneedles 2 are formed in a region excluding the peripheral portion 3a of the oil gel sheet 3 (see FIG. 1B), the microneedle patch 1 in which the sheet-like base 4 is formed in the region is the periphery. Part 3a.
  • the sheet-like substrate 4 is for supporting the plurality of microneedles 2, and the material thereof may be the same as or different from the material used for the microneedles 2.
  • the material of the sheet-like substrate 4 is, for example, the same water-soluble polymer as that of the microneedles, the sheet-like substrate 4 is dissolved by the moisture evaporated from the skin, and the cosmetic component can penetrate into the skin.
  • the microneedle 2, the sheet-like base body 4, and the oil gel sheet 3 can all be the microneedle patch 1 containing a cosmetic component.
  • the thickness of the sheet-like substrate 4 is, for example, 10 ⁇ m or more and 500 ⁇ m or less, preferably 20 ⁇ m or more and 80 ⁇ m or less so that the mechanical strength of the entire sheet can be secured and can be flexibly deformed according to the shape of the skin. Good.
  • a mold 10 having a plurality of recesses 10a is prepared (see FIG. 5A).
  • a resin sheet, a metal, or the like can be used as the material of the mold.
  • a method for forming the recess in the case of a resin sheet, a method of pressing a stamper having the same shape as that of the microneedle against the resin sheet may be used.
  • a method such as cutting or electric discharge machining may be used.
  • the recess is filled with the raw material liquid 2a. As shown in FIG.
  • the raw material liquid is supplied from the flat surface of the mold to a height corresponding to the thickness of the sheet-like substrate.
  • a filling method a method using a known device such as an inkjet, a dispenser, a dispenser, or a squeegee can be used.
  • the oil gel sheet 3 is bonded to the sheet-like substrate 4 (see FIG. 5C).
  • the microneedle patch 1 is peeled from the mold (see FIG. 5D).
  • the microneedles 2 and the sheet-like substrate 4 can be integrally formed.
  • the package 6 of the microneedle patch includes an oil gel sheet 3 and a plurality of microneedles 2 formed in a region excluding the peripheral portion 3a of the oil gel sheet and having an adhesive layer 5 formed on the surface facing the oil gel sheet.
  • 6 includes a microneedle patch 1 and a storage sheet 7 that covers a peripheral portion 3a of the oil gel sheet and includes a storage portion 9 in which a plurality of microrecesses 8 are formed and a plurality of microneedles are stored (FIG. 6 ( a) and (b)).
  • the microneedle patch 1 includes an oil gel sheet 3 and a plurality of microneedles 2 formed in a region excluding the peripheral portion 3a of the oil gel sheet and having an adhesive layer 5 formed on a surface facing the oil gel sheet (see FIG. 6 (b)). Since the microneedles 2 are formed in a region excluding the peripheral portion 3a of the oil gel sheet 3, the microneedle patch 1 is brought into close contact with the skin by the peripheral portion 3a of the oil gel sheet 3 after the microneedles 2 are inserted into the skin. be able to. An adhesive layer 5 is formed on the surface of the microneedle 2 facing the oil gel sheet 3, in other words, on the bottom surface of the microneedle 2.
  • the adhesive layer 5 is preferably formed of a material having moisture permeability. If it does in this way, the water
  • the storage sheet 7 has a storage portion 9 that covers the peripheral portion 3a of the oil gel sheet, has a plurality of minute recesses 8 and stores a plurality of microneedles.
  • the storage sheet 7 for example, a sheet in which a thermoplastic resin such as polypropylene or polyethylene is formed in a sheet shape can be used.
  • the minute recess 8 has the same shape as the minute needle 2. In the state of the package, the minute recess 8 is a storage portion 9 for storing the minute needle 2 and has a function of protecting the minute needle 2.
  • the storage sheet 7 covers the peripheral portion 3 a of the oil gel sheet 3. Due to the adhesive force of the oil gel sheet 3, the peripheral portion 3a and the surface of the storage sheet 7 facing it can be brought into close contact with each other.
  • the peel strength between the oil gel sheet 3 and the microneedles 2 is preferably higher than the peel strength between the microneedles 2 and the storage sheet 7. In this way, when the microneedle patch 1 is peeled from the storage sheet 7, the microneedles 2 can be reliably peeled from the storage sheet 7.
  • the microneedle patch of the present invention uses an oil gel sheet, the microneedle patch can be used even when the microneedles are formed of a water-soluble polymer and the adhesive layer is formed of a material having moisture permeability. The shape of the microneedles can be maintained until immediately before being applied to the skin.
  • the minute recessed part 8 is formed in a thermoplastic resin sheet, and the storage sheet 7 is formed (refer Fig.7 (a)).
  • the minute recesses 8 can be formed by pressing a stamper having the same shape as the minute needles against the thermoplastic resin sheet.
  • the raw material liquid 2a is filled into the minute recesses 8 (see FIG. 7B).
  • a filling method a method using a known device such as an inkjet, a dispenser, a dispenser, or a squeegee can be used. After filling, it is dried and a double-sided tape is bonded to the storage sheet 7.
  • the double-sided tape is provided with separator films 5b on both sides of the adhesive layer 5, and is bonded to the surface of the storage sheet 7 so as to peel off one separator film 5b and cover the microneedles 2 (see FIG. 7C). ).
  • the separator film 5b and the adhesive layer 5 are punched into the outer shape of the bottom surface of the micro needle 2 to form a cut 5a (see FIG. 7D).
  • the separator film 5b and the adhesive layer 5 of an unnecessary part are peeled (refer FIG.8 (e)).
  • the oil gel sheet 3 is bonded to the surface of the storage sheet 7 (see FIG. 8F).
  • the adhesive layer 5 is formed with a small thickness
  • the step between the adhesive layer and the storage sheet 7 is absorbed by an elastic oil gel.
  • the oil gel sheet 3 and the storage sheet 7 are punched into the outer shape of the microneedle patch 1 to obtain a package 6 of the microneedle patch (see FIG. 8G).
  • the package of the microneedle patch of the present invention uses an oil gel sheet, even if the microneedle is formed of a water-soluble polymer and the adhesive layer is formed of a material having moisture permeability, the microneedle patch The shape of the microneedles can be maintained during the manufacture of the package.
  • a package 6 of microneedle patches according to a modification of the above embodiment will be described.
  • the package 6 of the microneedle patch according to the modification is formed in the same shape as the adhesive layer on the oil gel sheet 3, the adhesive layer 5 formed in the region excluding the peripheral portion 3a of the oil gel sheet, and the adhesive layer.
  • a microneedle patch 1 comprising a sheet-like substrate 4 and a plurality of microneedles 2 formed on the sheet-like substrate; and a peripheral portion 3a of the oil gel sheet; And a storage sheet 7 having a storage portion 9 in which the microneedles 2 are stored (see FIGS. 9A and 9B).
  • the microneedle patch 1 includes an oil gel sheet 3, an adhesive layer 5 formed in a region excluding the peripheral portion 3a of the oil gel sheet, and a sheet-like substrate 4 formed on the adhesive layer 5 in the same shape as the adhesive layer 5. And a plurality of microneedles 2 formed on the sheet-like substrate 4 (see FIG. 9B).
  • a structure in which the plurality of microneedles 2 are formed on the sheet-like substrate 4 is referred to as a microneedle sheet. Since the adhesive layer 5 is formed in a region excluding the peripheral portion 3a of the oil gel sheet 3, the microneedle patch 1 can be brought into close contact with the skin by the peripheral portion 3a.
  • the adhesive layer 5 is preferably formed of a material having moisture permeability.
  • Both sides of the adhesive layer 5 may be adhesive surfaces, or only one surface may be an adhesive surface. When only one surface is an adhesive surface, it is good to emboss the surface which is not an adhesive surface. In this way, the surface area of the non-adhesive surface is increased, so that the adhesion between the non-adhesive surface and the sheet-like substrate 4 or the non-adhesive surface and the oil gel sheet 3 can be increased.
  • the peel strength between the oil gel sheet 3 and the microneedle sheet is preferably higher than the peel strength between the microneedle sheet and the storage sheet 7. In this way, the microneedle sheet can be reliably peeled from the storage sheet 7 when the microneedle patch 1 is peeled from the storage sheet 7.
  • the micro recessed part 8 is formed in a thermoplastic resin sheet, and the storage sheet 7 is formed (refer Fig.10 (a)).
  • the minute recesses 8 can be formed by pressing a stamper having the same shape as the minute needles against the thermoplastic resin sheet.
  • the raw material liquid 2a is filled into the minute recesses 8. At this time, the raw material liquid is supplied from the flat surface of the mold to a height corresponding to the thickness of the sheet-like substrate. (See FIG. 10B).
  • a method using a known device such as an inkjet, a dispenser, a dispenser, or a squeegee can be used. After filling, it is dried and a double-sided tape is bonded to the storage sheet 7. One separator film 5b of the double-sided tape is peeled off and bonded to the surface of the storage sheet 7 so as to cover the microneedles 2 (see FIG. 10C). Next, the separator film 5b, the adhesive layer 5, and the sheet-like substrate 4 are punched into the outer shape of the microneedle sheet to form a cut 5a (see FIG. 10D). Next, the separator film 5b, the unnecessary adhesive layer 5 and the sheet-like substrate 4 are peeled off (see FIG. 11E).
  • the oil gel sheet 3 is bonded to the storage sheet 7 (see FIG. 11 (f)).
  • a step due to the thickness of the sheet-like substrate 4 is formed on the surface of the oil gel sheet 3.
  • the oil gel sheet 3 and the storage sheet 7 are punched into the outer shape of the microneedle patch 1 to obtain a package 6 of the microneedle patch (see FIG. 11G).
  • a single-sided tape can be used instead of the double-sided tape.
  • the non-adhesive surface of the single-sided tape is embossed, and the non-adhesive surface is bonded to the sheet-like substrate 4 in FIG. 10C, the raw material liquid 2a is not completely dried. It is better to dry it. If it does in this way, since the surface area increases by embossing, even if it is not an adhesive surface, the sheet-like base
  • the adhesive surface is bonded to the sheet-like substrate 4, the embossed surface and the oil gel sheet 3 can be brought into close contact with each other.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

[Problem] To provide a microneedle patch with which it is possible to obtain a cosmetic effect even from a part thereof affixed to the skin, and a packing material for such a microneedle patch. [Solution] This microneedle patch has a configuration provided with an oil gel sheet and a plurality of microneedles formed in a region not including a peripheral portion of the oil gel sheet. A packing material has a configuration provided with the microneedle patch, and an accommodating sheet which covers the peripheral portion of the oil gel sheet and includes an accommodating portion in which a plurality of minute recessed portions are formed to accommodate the plurality of microneedles. Further, the packing material has a configuration provided with: a microneedle patch which is provided with an oil gel sheet, an adhesive layer formed in a region not including a peripheral portion of the oil gel sheet, a sheet-like substrate formed thereon with the same shape, and a plurality of microneedles formed thereon; and an accommodating sheet which covers the peripheral portion of the oil gel sheet and includes an accommodating portion in which a plurality of minute recessed portions are formed to accommodate the plurality of microneedles.

Description

マイクロニードルパッチとその梱包体Microneedle patch and its packaging
　本発明は、マイクロニードルパッチとその梱包体に関する。 The present invention relates to a microneedle patch and its package.
　マイクロニードルシートは、シート状基体の上に複数の微小針が形成されたものである。微小針を皮膚に刺すことにより、微小針に含まれた目的物質などの投与が可能となる。たとえば、特許文献１には、マイクロニードルシート２３を皮膚に固定するために、マイクロニードルシート２３の背面に粘着シート２６を設けたマイクロニードルパッチ２０が開示されている（図１２参照）。粘着シート２６の周辺部にはマイクロニードルシート２３が形成されていないため、粘着シート２６の周辺部の粘着層２４によって、マイクロニードルシート２３を皮膚に固定することができる。 The microneedle sheet has a plurality of microneedles formed on a sheet-like substrate. By inserting a microneedle into the skin, administration of a target substance contained in the microneedle becomes possible. For example, Patent Document 1 discloses a microneedle patch 20 in which an adhesive sheet 26 is provided on the back surface of the microneedle sheet 23 in order to fix the microneedle sheet 23 to the skin (see FIG. 12). Since the microneedle sheet 23 is not formed around the adhesive sheet 26, the microneedle sheet 23 can be fixed to the skin by the adhesive layer 24 around the adhesive sheet 26.
特開２０１６－１８９８４４号公報JP 2016-189844 A
　しかし、特許文献１に開示されている従来のマイクロニードルパッチでは、皮膚に貼り付けられる粘着層の部分からは美容効果を得ることができないという問題があった。また、従来のマイクロニードルパッチは、乳液やクリームなど（以下、乳液等という）を塗布した皮膚に貼ると、乳液等に含まれる油脂によって粘着層２４の粘着力が弱まるため、簡単に剥がれてしまうという問題があった。
　本発明は、この課題を解決するためになされたものであり、皮膚に貼り付けられた部分からも美容効果を得ることができ、乳液等を塗布した皮膚に貼っても剥がれにくいマイクロニードルパッチと、そのようなマイクロニードルパッチの梱包体を提供することを目的とする。 However, the conventional microneedle patch disclosed in Patent Document 1 has a problem in that a cosmetic effect cannot be obtained from the portion of the adhesive layer that is attached to the skin. In addition, when the conventional microneedle patch is applied to the skin to which the emulsion or cream (hereinafter referred to as emulsion) is applied, the adhesive force of the adhesive layer 24 is weakened by the fats and oils contained in the emulsion and the like, so that it easily peels off. There was a problem.
The present invention has been made in order to solve this problem, a microneedle patch that can obtain a cosmetic effect from a portion that is affixed to the skin, and that does not easily peel off even when affixed to the skin to which an emulsion or the like is applied. An object of the present invention is to provide a package of such a microneedle patch.
　以下に、課題を解決するための手段として複数の態様を説明する。これら態様は必要に応じて任意に組み合わせることができる。 Hereinafter, a plurality of modes will be described as means for solving the problem. These embodiments can be arbitrarily combined as necessary.
　本発明のマイクロニードルパッチは、オイルゲルシートと、オイルゲルシートの周辺部を除いた領域に形成された複数の微小針とを備えたものである。 The microneedle patch of the present invention includes an oil gel sheet and a plurality of microneedles formed in a region excluding the peripheral portion of the oil gel sheet.
　また、オイルゲルシートと複数の微小針との間であって複数の微小針が形成された領域にシート状基体をさらに備えたものであってもよい。 Further, a sheet-like substrate may be further provided in a region between the oil gel sheet and the plurality of microneedles where the plurality of microneedles are formed.
　また、複数の微小針のオイルゲルシートに対向する面に粘着層をさらに備えたものであってもよい。 Also, an adhesive layer may be further provided on the surface of the plurality of microneedles facing the oil gel sheet.
　また、シート状基体のオイルゲルシートに対向する面に粘着層をさらに備えたものであってもよい。 Further, an adhesive layer may be further provided on the surface of the sheet-like substrate facing the oil gel sheet.
　本発明のマイクロニードルパッチの梱包体は、オイルゲルシートと、オイルゲルシートの周辺部を除いた領域に形成されオイルゲルシートに対向する面に粘着層が形成された複数の微小針とを備えたマイクロニードルパッチと、オイルゲルシートの周辺部を覆い、複数の微小凹部が形成され複数の微小針が収納された収納部を有する収納シートとを備えたものである。 The microneedle patch package of the present invention comprises an oil gel sheet and a plurality of microneedles formed in a region excluding the peripheral portion of the oil gel sheet and having an adhesive layer formed on a surface facing the oil gel sheet. A patch and a storage sheet that covers a peripheral portion of the oil gel sheet and includes a storage portion in which a plurality of micro concave portions are formed and a plurality of micro needles are stored.
　また、本発明のマイクロニードルパッチの梱包体は、オイルゲルシートと、オイルゲルシートの周辺部を除いた領域に形成された粘着層と、粘着層の上に粘着層と同形状で形成されたシート状基体と、シート状基体の上に形成された複数の微小針とを備えたマイクロニードルパッチと、オイルゲルシートの周辺部を覆い、複数の微小凹部が形成され複数の微小針が収納された収納部を有する収納シートとを備えたものである。 Further, the package of the microneedle patch of the present invention is an oil gel sheet, an adhesive layer formed in a region excluding the peripheral part of the oil gel sheet, and a sheet formed on the adhesive layer in the same shape as the adhesive layer A microneedle patch having a base and a plurality of microneedles formed on the sheet-like base, and a storage portion that covers the periphery of the oil gel sheet and that has a plurality of microrecesses and that stores a plurality of microneedles And a storage sheet having.
　本発明のマイクロニードルパッチは、オイルゲルシートと、オイルゲルシートの周辺部を除いた領域に形成された複数の微小針とを備えるように構成した。したがって、本発明によれば、皮膚に貼り付けられた部分からも美容効果を得ることができ、乳液等を塗布した皮膚に貼っても剥がれにくいマイクロニードルパッチを提供することができる。 The microneedle patch of the present invention was configured to include an oil gel sheet and a plurality of microneedles formed in a region excluding the peripheral portion of the oil gel sheet. Therefore, according to the present invention, it is possible to provide a cosmetic effect even from a portion attached to the skin, and it is possible to provide a microneedle patch that does not easily peel off even when applied to the skin to which an emulsion or the like is applied.
　本発明のマイクロニードルパッチの梱包体は、オイルゲルシートと、オイルゲルシートの周辺部を除いた領域に形成されオイルゲルシートに対向する面に粘着層が形成された複数の微小針とを備えたマイクロニードルパッチと、オイルゲルシートの周辺部を覆い、複数の微小凹部が形成され複数の微小針が収納された収納部を有する収納シートとを備えるように構成した。したがって、本発明によれば、皮膚に貼り付けられた部分からも美容効果を得ることができ、乳液等を塗布した皮膚に貼っても剥がれにくいマイクロニードルパッチの梱包体を提供することができる。 The microneedle patch package of the present invention comprises an oil gel sheet and a plurality of microneedles formed in a region excluding the peripheral portion of the oil gel sheet and having an adhesive layer formed on a surface facing the oil gel sheet. A patch and a storage sheet that covers a peripheral portion of the oil gel sheet and includes a storage portion in which a plurality of micro concave portions are formed and a plurality of micro needles are stored are provided. Therefore, according to the present invention, it is possible to provide a cosmetic effect from a portion attached to the skin, and it is possible to provide a package of microneedle patches that do not easily peel off even when applied to the skin to which an emulsion or the like is applied.
　また、本発明のマイクロニードルパッチの梱包体は、オイルゲルシートと、オイルゲルシートの周辺部を除いた領域に形成された粘着層と、粘着層の上に粘着層と同形状で形成されたシート状基体と、シート状基体の上に形成された複数の微小針とを備えたマイクロニードルパッチと、オイルゲルシートの周辺部を覆い、複数の微小凹部が形成され複数の微小針が収納された収納部を有する収納シートとを備えるように構成した。したがって、本発明によれば、皮膚に貼り付けられた部分からも美容効果を得ることができ、乳液等を塗布した皮膚に貼っても剥がれにくいマイクロニードルパッチの梱包体を提供することができる。 Further, the package of the microneedle patch of the present invention is an oil gel sheet, an adhesive layer formed in a region excluding the peripheral part of the oil gel sheet, and a sheet formed on the adhesive layer in the same shape as the adhesive layer A microneedle patch having a base and a plurality of microneedles formed on the sheet-like base, and a storage portion that covers the periphery of the oil gel sheet and that has a plurality of microrecesses and that stores a plurality of microneedles And a storage sheet having the structure. Therefore, according to the present invention, it is possible to provide a cosmetic effect from a portion attached to the skin, and it is possible to provide a package of microneedle patches that do not easily peel off even when applied to the skin to which an emulsion or the like is applied.
（ａ）本発明のマイクロニードルパッチの一実施形態を示す模式的な斜視図である。（ｂ）（ａ）のＡ－Ａ断面図である。(A) It is a typical perspective view which shows one Embodiment of the microneedle patch of this invention. (B) It is AA sectional drawing of (a). 本発明のマイクロニードルパッチの製造方法の一例を示す模式的な断面図である。It is typical sectional drawing which shows an example of the manufacturing method of the microneedle patch of this invention. 本発明のマイクロニードルパッチの製造方法の一例を示す模式的な断面図である。It is typical sectional drawing which shows an example of the manufacturing method of the microneedle patch of this invention. 本発明のマイクロニードルパッチの変形例を示す模式的な断面図である。It is typical sectional drawing which shows the modification of the microneedle patch of this invention. 本発明のマイクロニードルパッチの変形例に係る製造方法の一例を示す模式的な断面図である。It is typical sectional drawing which shows an example of the manufacturing method which concerns on the modification of the microneedle patch of this invention. 本発明のマイクロニードルパッチの梱包体の一実施形態を示す模式的な断面図である。It is typical sectional drawing which shows one Embodiment of the package body of the microneedle patch of this invention. 本発明のマイクロニードルパッチの梱包体の製造方法の一例を示す模式的な断面図である。It is typical sectional drawing which shows an example of the manufacturing method of the package of the microneedle patch of this invention. 本発明のマイクロニードルパッチの梱包体の製造方法の一例を示す模式的な断面図である。It is typical sectional drawing which shows an example of the manufacturing method of the package of the microneedle patch of this invention. 本発明のマイクロニードルパッチの梱包体の変形例を示す模式的な断面図である。It is typical sectional drawing which shows the modification of the package body of the microneedle patch of this invention. 本発明のマイクロニードルパッチの梱包体の変形例に係る製造方法の一例を示す模式的な断面図である。It is typical sectional drawing which shows an example of the manufacturing method which concerns on the modification of the package of the microneedle patch of this invention. 本発明のマイクロニードルパッチの梱包体の変形例に係る製造方法の一例を示す模式的な断面図である。It is typical sectional drawing which shows an example of the manufacturing method which concerns on the modification of the package of the microneedle patch of this invention. 従来のマイクロニードルパッチを示す模式的な断面図である。It is typical sectional drawing which shows the conventional microneedle patch.
　本発明のマイクロニードルパッチについて実施形態の一例を説明する。本発明のマイクロニードルパッチ１は、オイルゲルシート３と、オイルゲルシート３の周辺部３ａを除いた領域に形成された複数の微小針２とを備えたものである（図１（ａ）、（ｂ）参照）。 An example of the embodiment of the microneedle patch of the present invention will be described. The microneedle patch 1 of the present invention includes an oil gel sheet 3 and a plurality of microneedles 2 formed in a region excluding the peripheral portion 3a of the oil gel sheet 3 (FIGS. 1A and 1B). )reference).
　オイルゲルシート３は、支持体の上にオイルゲルが形成されたシートである。支持体としては不織布、織布などの材料を用いることができる。オイルゲルは、油溶性成分を含むゲルであり、皮膚に対する粘着性がよい。油溶性成分は、皮膚に貼り付けた後に皮膚内に浸透し、美容効果を与えることができるものであれば、特に限定されない。そのような成分としては、たとえば、油溶性ビタミンＣ誘導体、レチノール誘導体、アスタキサンチン、スクワラン、植物由来オイル、セラミド（スフィンゴ脂質）、トコフェロール（ビタミンＥ）などを挙げることができる。 The oil gel sheet 3 is a sheet in which an oil gel is formed on a support. A material such as a nonwoven fabric or a woven fabric can be used as the support. The oil gel is a gel containing an oil-soluble component and has good adhesiveness to the skin. The oil-soluble component is not particularly limited as long as it can permeate into the skin after being applied to the skin and give a cosmetic effect. Examples of such components include oil-soluble vitamin C derivatives, retinol derivatives, astaxanthin, squalane, plant-derived oil, ceramide (sphingolipid), tocopherol (vitamin E), and the like.
　微小針２は、オイルゲルシート３の周辺部３ａを除いた領域に形成されている。そのため、微小針２を皮膚に刺した後はオイルゲルシート３の周辺部３ａによってマイクロニードルパッチ１を皮膚に密着させることができる。微小針２は、たとえば、円錐形、角錐形、円錐台形、コニーデ形などとすることができる。コニーデ形とは、円錐形または円錐台形の側面が内向きに湾曲した形状を表す。オイルゲルシート３からの微小針２の突出高さは、たとえば、１０μｍ以上５００μｍ以下とすることができる。微小針２の密度は、たとえば、１００本／ｃｍ２以上５００本／ｃｍ２以下とすることができる。 The microneedles 2 are formed in a region excluding the peripheral portion 3 a of the oil gel sheet 3. Therefore, after the microneedle 2 is stabbed into the skin, the microneedle patch 1 can be brought into close contact with the skin by the peripheral portion 3a of the oil gel sheet 3. The microneedles 2 can be, for example, conical, pyramidal, frustoconical, and conical. The coneide shape represents a shape in which a side surface of a cone shape or a truncated cone shape is curved inward. The protruding height of the microneedles 2 from the oil gel sheet 3 can be, for example, not less than 10 μm and not more than 500 μm. The density of the microneedles 2 can be, for example, 100 / cm 2 or more and 500 / cm 2 or less.
　微小針２は、皮膚に刺した後に微小針そのものが皮膚内で溶解する材料で形成してもよいし、溶解しない材料で形成してもよい。皮膚内で溶解する材料としては、たとえば、ヒアルロン酸、コンドロイチン硫酸、コラーゲン、ゼラチン、グリコーゲン、デキストラン、デキストリン、キトサン、プロテオグリカン、プルラン、カルボキシメチルセルロース、ポリビニルアルコール、カルボキシビニルポリマーなどの水溶性高分子を用いることができる。これらの水溶性高分子は、１つだけを用いてもよいし、２つ以上を組み合わせて用いてもよい。また、これらの水溶性高分子には、水溶性の美容成分を添加してもよい。微小針を皮膚に刺すと、水溶性高分子が皮膚の水分によって溶解する。水溶性高分子そのものの性質、または添加した美容成分により、たとえば、皮膚を保湿することができる。皮膚内で溶解しない材料としては、たとえば、樹脂、金属を用いることができる。このような材料を用いた場合は、微小針の表面に、たとえば保湿効果を持つ水溶性の美容成分をコーティングするとよい。微小針を皮膚に刺すと、美容成分が皮膚内で溶解し、皮膚を保湿することができる。 The microneedle 2 may be formed of a material that the microneedle itself dissolves in the skin after piercing the skin, or may be formed of a material that does not dissolve. Examples of materials that dissolve in the skin include water-soluble polymers such as hyaluronic acid, chondroitin sulfate, collagen, gelatin, glycogen, dextran, dextrin, chitosan, proteoglycan, pullulan, carboxymethylcellulose, polyvinyl alcohol, and carboxyvinyl polymer. be able to. These water-soluble polymers may be used alone or in combination of two or more. In addition, a water-soluble cosmetic ingredient may be added to these water-soluble polymers. When a microneedle is stabbed into the skin, the water-soluble polymer is dissolved by the moisture of the skin. For example, the skin can be moisturized by the nature of the water-soluble polymer itself or the added cosmetic ingredient. As a material that does not dissolve in the skin, for example, a resin or a metal can be used. When such a material is used, for example, a water-soluble cosmetic component having a moisturizing effect may be coated on the surface of the microneedles. When a microneedle is inserted into the skin, the cosmetic ingredients dissolve in the skin, and the skin can be moisturized.
　本発明のマイクロニードルパッチ１は、美容成分を含むオイルゲルシート３により皮膚に密着させる。そのため、微小針２に加え、皮膚に貼り付けられたオイルゲルシート３の周辺部３ａからも美容効果を得ることができる。また、オイルゲルシート３は粘着性が高く密着して貼り付けることができるが、マイクロニードルパッチ１を剥がす際には角質が剥がれにくく、安全性が高い。また、本発明のマイクロニードルパッチはオイルゲルシートを使用しているため、微小針を水溶性高分子で形成した場合であっても、マイクロニードルパッチを皮膚に貼り付ける直前まで微小針の形状を保持することができる。したがって、使用者が使用直前に微小針とオイルゲルシートとを組み合わせる必要がない。 The microneedle patch 1 of the present invention is brought into close contact with the skin by an oil gel sheet 3 containing cosmetic ingredients. Therefore, in addition to the microneedles 2, a cosmetic effect can be obtained from the peripheral portion 3a of the oil gel sheet 3 attached to the skin. In addition, the oil gel sheet 3 has high adhesiveness and can be adhered and pasted, but when the microneedle patch 1 is peeled off, the keratin is hardly peeled off and the safety is high. In addition, since the microneedle patch of the present invention uses an oil gel sheet, even when the microneedle is formed of a water-soluble polymer, the shape of the microneedle is maintained until immediately before the microneedle patch is applied to the skin. can do. Therefore, it is not necessary for the user to combine the micro needle and the oil gel sheet immediately before use.
　また、本発明のマイクロニードルパッチ１は、オイルゲルシート３を用いているため、乳液等を塗布した皮膚に貼ることができ、貼った後でも剥がれにくい。これは、オイルゲルシート３が含んでいる油分と乳液等に含まれる油脂とがなじみやすいためである。また、上記と同様の理由により、皮脂の分泌量が多い皮膚であっても貼ることができ、貼った後でも剥がれにくいマイクロニードルパッチとすることができる。 Moreover, since the microneedle patch 1 of the present invention uses the oil gel sheet 3, it can be applied to the skin to which an emulsion or the like is applied, and is difficult to peel off even after being applied. This is because the oil contained in the oil gel sheet 3 and the fats and oils contained in the emulsion are easily compatible. For the same reason as described above, it can be applied even to skin with a large amount of sebum secretion, and a microneedle patch that does not easily peel off even after being applied can be obtained.
　本発明のマイクロニードルパッチは、従来用いられている公知の方法によって製造することができる。 The microneedle patch of the present invention can be manufactured by a conventionally known method.
　たとえば、複数の凹部１０ａが形成された型１０を用意する（図２（ａ）参照）。型の材料は、樹脂シートや金属などを用いることができる。凹部の形成方法としては、樹脂シートの場合、微小針と同形状を有するスタンパを樹脂シートに押し付ける方法を用いるとよい。金属の場合は、切削加工や放電加工などの方法を用いるとよい。次に、凹部に原料液２ａを充填する（図２（ｂ）参照）。充填方法は、インクジェット、ディスペンサ、分注器、スキージなど公知の機器を使用した方法を用いることができる。充填後は乾燥させ、オイルゲルシート３を微小針２の底面と貼り合わせる（図２（ｃ）参照）。最後に、型からマイクロニードルパッチ１を剥離する（図２（ｄ）参照）。 For example, a mold 10 having a plurality of recesses 10a is prepared (see FIG. 2A). As the material of the mold, a resin sheet, a metal, or the like can be used. As a method for forming the recess, in the case of a resin sheet, a method of pressing a stamper having the same shape as that of the microneedle against the resin sheet may be used. In the case of metal, a method such as cutting or electric discharge machining may be used. Next, the concave portion is filled with the raw material liquid 2a (see FIG. 2B). As a filling method, a method using a known device such as an inkjet, a dispenser, a dispenser, or a squeegee can be used. After filling, the oil gel sheet 3 is bonded to the bottom surface of the micro needle 2 (see FIG. 2C). Finally, the microneedle patch 1 is peeled from the mold (see FIG. 2 (d)).
　あるいは、次のような製造方法も用いることができる。まず、オイルゲルシート３の上に原料液２ａを滴下して付着させ（図３（ａ）参照）、原料液２ａが付着した面に向かい合う方向からプレート１１を近づけて、プレート１１に原料液１０ａを接触させる（図３（ｂ）参照）。その後プレート１１を、オイルゲルシート３に平行な状態でオイルゲルシート３から徐々に離していくことで複数の微小針２を形成する（図３（ｃ）参照）。したがって原料液２ａは、プレート１１の引き離しによって糸を引く程度の粘度を有することが好ましい。なお溶媒としては、水の他、水溶性高分子が可溶する媒体を選択することができる。 Alternatively, the following manufacturing method can also be used. First, the raw material liquid 2a is dropped and adhered onto the oil gel sheet 3 (see FIG. 3A), the plate 11 is brought closer to the plate 11 from the direction facing the surface to which the raw material liquid 2a is adhered, and the raw material liquid 10a is applied to the plate 11. Contact is made (see FIG. 3B). Thereafter, the plate 11 is gradually separated from the oil gel sheet 3 in a state parallel to the oil gel sheet 3 to form a plurality of microneedles 2 (see FIG. 3C). Therefore, it is preferable that the raw material liquid 2a has a viscosity enough to pull the yarn when the plate 11 is pulled away. As a solvent, a medium in which a water-soluble polymer is soluble in addition to water can be selected.
　微小針を、たとえば樹脂または金属といった皮膚内で溶解しない材料で形成する場合は、樹脂または金属を微小針の形に削り出して形成することができる。金属で形成する場合は、皮膚に刺さらない円錐台形にするとよい。このようにすると、金属製の微小針が皮膚内に残留するのを防止することができ、マイクロニードルパッチの安全性を高めることができる。 When the microneedle is formed of a material that does not dissolve in the skin, such as resin or metal, the resin or metal can be formed by cutting it into the shape of a microneedle. When it is made of metal, it should have a truncated cone shape that does not pierce the skin. If it does in this way, it can prevent that metal microneedles remain in skin, and can improve the safety of a microneedle patch.
　本発明のマイクロニードルパッチはオイルゲルシートを使用しているため、微小針を水溶性高分子で形成した場合であっても、マイクロニードルパッチの製造時に微小針の形状を保持しておくことができる。 Since the microneedle patch of the present invention uses an oil gel sheet, the shape of the microneedle can be maintained during the production of the microneedle patch even when the microneedle is formed of a water-soluble polymer. .
（変形例）
　上記実施形態の変形例に係るマイクロニードルパッチ１を説明する。変形例に係るマイクロニードルパッチ１は、オイルゲルシート３と複数の微小針２との間であって複数の微小針２が形成された領域にシート状基体４をさらに備えたものである（図４参照）。 (Modification)
The microneedle patch 1 which concerns on the modification of the said embodiment is demonstrated. The microneedle patch 1 according to the modified example further includes a sheet-like substrate 4 in a region between the oil gel sheet 3 and the plurality of microneedles 2 where the plurality of microneedles 2 are formed (FIG. 4). reference).
　シート状基体４は、複数の微小針２が形成された領域に形成する。複数の微小針２は、オイルゲルシート３の周辺部３ａを除いた領域に形成されているため（図１（ｂ）参照）、その領域にシート状基体４が形成されたマイクロニードルパッチ１は周辺部３ａを有する。 The sheet-like substrate 4 is formed in a region where a plurality of microneedles 2 are formed. Since the plurality of microneedles 2 are formed in a region excluding the peripheral portion 3a of the oil gel sheet 3 (see FIG. 1B), the microneedle patch 1 in which the sheet-like base 4 is formed in the region is the periphery. Part 3a.
　シート状基体４は、複数の微小針２を支持するためのものであり、その材料は微小針２に用いられる材料と同じであってもよいし、異なっていてもよい。シート状基体４の材料が、たとえば、微小針と同じ水溶性高分子の場合は、皮膚から蒸散される水分によってシート状基体４が溶解し、美容成分が皮膚内に浸透することができる。また、微小針２、シート状基体４、オイルゲルシート３のすべてが美容成分を含んだマイクロニードルパッチ１とすることができる。 The sheet-like substrate 4 is for supporting the plurality of microneedles 2, and the material thereof may be the same as or different from the material used for the microneedles 2. When the material of the sheet-like substrate 4 is, for example, the same water-soluble polymer as that of the microneedles, the sheet-like substrate 4 is dissolved by the moisture evaporated from the skin, and the cosmetic component can penetrate into the skin. Moreover, the microneedle 2, the sheet-like base body 4, and the oil gel sheet 3 can all be the microneedle patch 1 containing a cosmetic component.
　シート状基体４の厚みは、シート全体の機械的強度が確保可能であり、かつ、皮膚の形状に応じて柔軟に変形可能なように、たとえば１０μｍ以上５００μｍ以下、好ましくは２０μｍ以上８０μｍ以下に構成するとよい。 The thickness of the sheet-like substrate 4 is, for example, 10 μm or more and 500 μm or less, preferably 20 μm or more and 80 μm or less so that the mechanical strength of the entire sheet can be secured and can be flexibly deformed according to the shape of the skin. Good.
　変形例に係るマイクロニードルパッチ１の製造方法の一例を説明する（図５参照）。まず、複数の凹部１０ａが形成された型１０を用意する（図５（ａ）参照）。型の材料は、樹脂シートや金属などを用いることができる。凹部の形成方法としては、樹脂シートの場合、微小針と同形状を有するスタンパを樹脂シートに押し付ける方法を用いるとよい。金属の場合は、切削加工や放電加工などの方法を用いるとよい。次に、凹部に原料液２ａを充填する。図５（ｂ）のように、型の平坦面からシート状基体の厚みに相当する高さまで原料液を供給する。充填方法は、インクジェット、ディスペンサ、分注器、スキージなど公知の機器を使用した方法を用いることができる。充填後は乾燥させ、オイルゲルシート３をシート状基体４と貼り合わせる（図５（ｃ）参照）。最後に、型からマイクロニードルパッチ１を剥離する（図５（ｄ）参照）。この製造方法では、微小針２とシート状基体４とを一体形成できる。 An example of a method for manufacturing the microneedle patch 1 according to the modification will be described (see FIG. 5). First, a mold 10 having a plurality of recesses 10a is prepared (see FIG. 5A). As the material of the mold, a resin sheet, a metal, or the like can be used. As a method for forming the recess, in the case of a resin sheet, a method of pressing a stamper having the same shape as that of the microneedle against the resin sheet may be used. In the case of metal, a method such as cutting or electric discharge machining may be used. Next, the recess is filled with the raw material liquid 2a. As shown in FIG. 5B, the raw material liquid is supplied from the flat surface of the mold to a height corresponding to the thickness of the sheet-like substrate. As a filling method, a method using a known device such as an inkjet, a dispenser, a dispenser, or a squeegee can be used. After filling, the oil gel sheet 3 is bonded to the sheet-like substrate 4 (see FIG. 5C). Finally, the microneedle patch 1 is peeled from the mold (see FIG. 5D). In this manufacturing method, the microneedles 2 and the sheet-like substrate 4 can be integrally formed.
（マイクロニードルパッチの梱包体）
　次に、本発明のマイクロニードルパッチの梱包体について実施形態の一例を説明する。マイクロニードルパッチの梱包体６は、オイルゲルシート３と、オイルゲルシートの周辺部３ａを除いた領域に形成されオイルゲルシートに対向する面に粘着層５が形成された複数の微小針２とを備えたマイクロニードルパッチ１と、オイルゲルシートの周辺部３ａを覆い、複数の微小凹部８が形成され複数の微小針が収納された収納部９を有する収納シート７とを備えたものである（図６（ａ）、（ｂ）参照）。 (Packaging body of microneedle patch)
Next, an example of the embodiment of the package of the microneedle patch of the present invention will be described. The package 6 of the microneedle patch includes an oil gel sheet 3 and a plurality of microneedles 2 formed in a region excluding the peripheral portion 3a of the oil gel sheet and having an adhesive layer 5 formed on the surface facing the oil gel sheet. 6 includes a microneedle patch 1 and a storage sheet 7 that covers a peripheral portion 3a of the oil gel sheet and includes a storage portion 9 in which a plurality of microrecesses 8 are formed and a plurality of microneedles are stored (FIG. 6 ( a) and (b)).
　マイクロニードルパッチ１は、オイルゲルシート３と、オイルゲルシートの周辺部３ａを除いた領域に形成されオイルゲルシートに対向する面に粘着層５が形成された複数の微小針２とを備えている（図６（ｂ）参照）。微小針２は、オイルゲルシート３の周辺部３ａを除いた領域に形成されているため、微小針２を皮膚に刺した後はオイルゲルシート３の周辺部３ａによってマイクロニードルパッチ１を皮膚に密着させることができる。微小針２のオイルゲルシート３に対向する面、言い換えると微小針２の底面には粘着層５を形成する。粘着層５は、透湿性を有する材料で形成するのが好ましい。このようにすると、微小針２が吸収した皮膚の水分が粘着層５を介して適度に放散され、皮膚が蒸れるのを防止することができる。粘着層５は両面が粘着面である。 The microneedle patch 1 includes an oil gel sheet 3 and a plurality of microneedles 2 formed in a region excluding the peripheral portion 3a of the oil gel sheet and having an adhesive layer 5 formed on a surface facing the oil gel sheet (see FIG. 6 (b)). Since the microneedles 2 are formed in a region excluding the peripheral portion 3a of the oil gel sheet 3, the microneedle patch 1 is brought into close contact with the skin by the peripheral portion 3a of the oil gel sheet 3 after the microneedles 2 are inserted into the skin. be able to. An adhesive layer 5 is formed on the surface of the microneedle 2 facing the oil gel sheet 3, in other words, on the bottom surface of the microneedle 2. The adhesive layer 5 is preferably formed of a material having moisture permeability. If it does in this way, the water | moisture content of the skin which the microneedle 2 absorbed can be dissipated moderately through the adhesion layer 5, and it can prevent that the skin gets muddy. Both sides of the adhesive layer 5 are adhesive surfaces.
　収納シート７は、オイルゲルシートの周辺部３ａを覆い、複数の微小凹部８が形成され複数の微小針が収納された収納部９を有するものである。収納シート７は、たとえば、ポリプロピレン、ポリエチレンなどの熱可塑性樹脂をシート状に形成したものを用いることができる。微小凹部８は微小針２と同形状を有する。梱包体の状態では、微小凹部８は微小針２を収納する収納部９であり、微小針２を保護する機能を持つ。また、収納シート７は、オイルゲルシート３の周辺部３ａを覆う。オイルゲルシート３の粘着力により、周辺部３ａとそれに対向する収納シート７の面とを密着することができる。 The storage sheet 7 has a storage portion 9 that covers the peripheral portion 3a of the oil gel sheet, has a plurality of minute recesses 8 and stores a plurality of microneedles. As the storage sheet 7, for example, a sheet in which a thermoplastic resin such as polypropylene or polyethylene is formed in a sheet shape can be used. The minute recess 8 has the same shape as the minute needle 2. In the state of the package, the minute recess 8 is a storage portion 9 for storing the minute needle 2 and has a function of protecting the minute needle 2. The storage sheet 7 covers the peripheral portion 3 a of the oil gel sheet 3. Due to the adhesive force of the oil gel sheet 3, the peripheral portion 3a and the surface of the storage sheet 7 facing it can be brought into close contact with each other.
　オイルゲルシート３と微小針２との剥離強度は、微小針２と収納シート７との剥離強度より高いことが好ましい。このようにすると、マイクロニードルパッチ１を収納シート７から剥離する際に、微小針２を収納シート７から確実に剥離することができる。 The peel strength between the oil gel sheet 3 and the microneedles 2 is preferably higher than the peel strength between the microneedles 2 and the storage sheet 7. In this way, when the microneedle patch 1 is peeled from the storage sheet 7, the microneedles 2 can be reliably peeled from the storage sheet 7.
　本発明のマイクロニードルパッチの梱包体は、オイルゲルシートを用いているため、微小針を水溶性高分子で形成し、粘着層を透湿性を有する材料で形成した場合であっても、マイクロニードルパッチを皮膚に貼り付ける直前まで微小針の形状を保持することができる。 Since the package of the microneedle patch of the present invention uses an oil gel sheet, the microneedle patch can be used even when the microneedles are formed of a water-soluble polymer and the adhesive layer is formed of a material having moisture permeability. The shape of the microneedles can be maintained until immediately before being applied to the skin.
　本発明のマイクロニードルパッチの梱包体の製造方法の一例を説明する（図７参照）。まず、熱可塑性樹脂シートに微小凹部８を形成し、収納シート７を形成する（図７（ａ）参照）。微小凹部８は、微小針と同形状を有するスタンパを熱可塑性樹脂シートに押し付けることで形成することができる。次に、微小凹部８に原料液２ａを充填する（図７（ｂ）参照）。充填方法は、インクジェット、ディスペンサ、分注器、スキージなど公知の機器を使用した方法を用いることができる。充填後は乾燥させ、収納シート７に両面テープを貼り合わせる。両面テープは粘着層５の両面にセパレータフィルム５ｂを備えたものであり、一方のセパレータフィルム５ｂを剥離し微小針２を覆うようにして収納シート７の表面に貼り合わせる（図７（ｃ）参照）。次に、セパレータフィルム５ｂと粘着層５とを微小針２の底面の外形に打ち抜き、切れ目５ａを形成する（図７（ｄ）参照）。次に、セパレータフィルム５ｂと、不要部分の粘着層５とを剥離する（図８（ｅ）参照）。次に、オイルゲルシート３を収納シート７の表面に貼り合わせる（図８（ｆ）参照）。粘着層５は小さい厚みで形成するため、粘着層と収納シート７との段差は弾性のあるオイルゲルに吸収される。最後に、オイルゲルシート３と収納シート７とをマイクロニードルパッチ１の外形に打ち抜き、マイクロニードルパッチの梱包体６を得る（図８（ｇ）参照）。 An example of the manufacturing method of the package of the microneedle patch of the present invention will be described (see FIG. 7). First, the minute recessed part 8 is formed in a thermoplastic resin sheet, and the storage sheet 7 is formed (refer Fig.7 (a)). The minute recesses 8 can be formed by pressing a stamper having the same shape as the minute needles against the thermoplastic resin sheet. Next, the raw material liquid 2a is filled into the minute recesses 8 (see FIG. 7B). As a filling method, a method using a known device such as an inkjet, a dispenser, a dispenser, or a squeegee can be used. After filling, it is dried and a double-sided tape is bonded to the storage sheet 7. The double-sided tape is provided with separator films 5b on both sides of the adhesive layer 5, and is bonded to the surface of the storage sheet 7 so as to peel off one separator film 5b and cover the microneedles 2 (see FIG. 7C). ). Next, the separator film 5b and the adhesive layer 5 are punched into the outer shape of the bottom surface of the micro needle 2 to form a cut 5a (see FIG. 7D). Next, the separator film 5b and the adhesive layer 5 of an unnecessary part are peeled (refer FIG.8 (e)). Next, the oil gel sheet 3 is bonded to the surface of the storage sheet 7 (see FIG. 8F). Since the adhesive layer 5 is formed with a small thickness, the step between the adhesive layer and the storage sheet 7 is absorbed by an elastic oil gel. Finally, the oil gel sheet 3 and the storage sheet 7 are punched into the outer shape of the microneedle patch 1 to obtain a package 6 of the microneedle patch (see FIG. 8G).
　本発明のマイクロニードルパッチの梱包体はオイルゲルシートを使用しているため、微小針を水溶性高分子で形成し、粘着層を透湿性を有する材料で形成した場合であっても、マイクロニードルパッチの梱包体の製造時に微小針の形状を保持しておくことができる。 Since the package of the microneedle patch of the present invention uses an oil gel sheet, even if the microneedle is formed of a water-soluble polymer and the adhesive layer is formed of a material having moisture permeability, the microneedle patch The shape of the microneedles can be maintained during the manufacture of the package.
（変形例）
　上記実施形態の変形例に係るマイクロニードルパッチの梱包体６を説明する。変形例に係るマイクロニードルパッチの梱包体６は、オイルゲルシート３と、オイルゲルシートの周辺部３ａを除いた領域に形成された粘着層５と、粘着層の上に粘着層と同形状で形成されたシート状基体４と、シート状基体の上に形成された複数の微小針２とを備えたマイクロニードルパッチ１と、オイルゲルシートの周辺部３ａを覆い、複数の微小凹部８が形成され複数の微小針２が収納された収納部９を有する収納シート７とを備えている（図９（ａ）、（ｂ）参照）。 (Modification)
A package 6 of microneedle patches according to a modification of the above embodiment will be described. The package 6 of the microneedle patch according to the modification is formed in the same shape as the adhesive layer on the oil gel sheet 3, the adhesive layer 5 formed in the region excluding the peripheral portion 3a of the oil gel sheet, and the adhesive layer. A microneedle patch 1 comprising a sheet-like substrate 4 and a plurality of microneedles 2 formed on the sheet-like substrate; and a peripheral portion 3a of the oil gel sheet; And a storage sheet 7 having a storage portion 9 in which the microneedles 2 are stored (see FIGS. 9A and 9B).
　マイクロニードルパッチ１は、オイルゲルシート３と、オイルゲルシートの周辺部３ａを除いた領域に形成された粘着層５と、粘着層５の上に粘着層５と同形状で形成されたシート状基体４と、シート状基体４の上に形成された複数の微小針２とを備えている（図９（ｂ）参照）。なお、以下では、シート状基体４の上に複数の微小針２が形成されたものを、マイクロニードルシートと呼ぶ。粘着層５は、オイルゲルシート３の周辺部３ａを除いた領域に形成するため、周辺部３ａによってマイクロニードルパッチ１を皮膚に密着させることができる。粘着層５は、透湿性を有する材料で形成するのが好ましい。このようにすると、マイクロニードルシートが吸収した皮膚の水分が粘着層５を介して適度に放散され、皮膚が蒸れるのを防止することができる。粘着層５は両面が粘着面であってもよいし、片面のみが粘着面であってもよい。片面のみが粘着面である場合は、粘着面でない面にはエンボス加工を施すとよい。このようにすると、粘着面でない面の表面積が増えるため、粘着面でない面とシート状基体４、または粘着面でない面とオイルゲルシート３との密着力を上げることができる。 The microneedle patch 1 includes an oil gel sheet 3, an adhesive layer 5 formed in a region excluding the peripheral portion 3a of the oil gel sheet, and a sheet-like substrate 4 formed on the adhesive layer 5 in the same shape as the adhesive layer 5. And a plurality of microneedles 2 formed on the sheet-like substrate 4 (see FIG. 9B). Hereinafter, a structure in which the plurality of microneedles 2 are formed on the sheet-like substrate 4 is referred to as a microneedle sheet. Since the adhesive layer 5 is formed in a region excluding the peripheral portion 3a of the oil gel sheet 3, the microneedle patch 1 can be brought into close contact with the skin by the peripheral portion 3a. The adhesive layer 5 is preferably formed of a material having moisture permeability. If it does in this way, the water | moisture content of the skin which the microneedle sheet | seat absorbed will be dissipated moderately through the adhesion layer 5, and it can prevent that skin gets muddy. Both sides of the adhesive layer 5 may be adhesive surfaces, or only one surface may be an adhesive surface. When only one surface is an adhesive surface, it is good to emboss the surface which is not an adhesive surface. In this way, the surface area of the non-adhesive surface is increased, so that the adhesion between the non-adhesive surface and the sheet-like substrate 4 or the non-adhesive surface and the oil gel sheet 3 can be increased.
　オイルゲルシート３とマイクロニードルシートとの剥離強度は、マイクロニードルシートと収納シート７との剥離強度より高いことが好ましい。このようにすると、マイクロニードルパッチ１を収納シート７から剥離する際に、マイクロニードルシートを収納シート７から確実に剥離することができる。 The peel strength between the oil gel sheet 3 and the microneedle sheet is preferably higher than the peel strength between the microneedle sheet and the storage sheet 7. In this way, the microneedle sheet can be reliably peeled from the storage sheet 7 when the microneedle patch 1 is peeled from the storage sheet 7.
　変形例に係るマイクロニードルパッチの梱包体の製造方法の一例を説明する（図１０参照）。まず、熱可塑性樹脂シートに微小凹部８を形成し、収納シート７を形成する（図１０（ａ）参照）。微小凹部８は、微小針と同形状を有するスタンパを熱可塑性樹脂シートに押し付けることで形成することができる。次に、微小凹部８に原料液２ａを充填する。このとき、型の平坦面からシート状基体の厚みに相当する高さまで原料液を供給する。（図１０（ｂ）参照）。充填方法は、インクジェット、ディスペンサ、分注器、スキージなど公知の機器を使用した方法を用いることができる。充填後は乾燥させ、収納シート７に両面テープを貼り合わせる。両面テープの一方のセパレータフィルム５ｂを剥離し微小針２を覆うようにして収納シート７の表面に貼り合わせる（図１０（ｃ）参照）。次に、セパレータフィルム５ｂ、粘着層５、およびシート状基体４をマイクロニードルシートの外形に打ち抜き、切れ目５ａを形成する（図１０（ｄ）参照）。次に、セパレータフィルム５ｂと、不要部分の粘着層５とシート状基体４とを剥離する（図１１（ｅ）参照）。次に、オイルゲルシート３を収納シート７と貼り合わせる（図１１（ｆ）参照）。オイルゲルシート３の表面には、シート状基体４の厚みによる段差ができる。最後に、オイルゲルシート３と収納シート７とをマイクロニードルパッチ１の外形に打ち抜き、マイクロニードルパッチの梱包体６を得る（図１１（ｇ）参照）。 An example of a method for manufacturing a package of microneedle patches according to a modification will be described (see FIG. 10). First, the micro recessed part 8 is formed in a thermoplastic resin sheet, and the storage sheet 7 is formed (refer Fig.10 (a)). The minute recesses 8 can be formed by pressing a stamper having the same shape as the minute needles against the thermoplastic resin sheet. Next, the raw material liquid 2a is filled into the minute recesses 8. At this time, the raw material liquid is supplied from the flat surface of the mold to a height corresponding to the thickness of the sheet-like substrate. (See FIG. 10B). As a filling method, a method using a known device such as an inkjet, a dispenser, a dispenser, or a squeegee can be used. After filling, it is dried and a double-sided tape is bonded to the storage sheet 7. One separator film 5b of the double-sided tape is peeled off and bonded to the surface of the storage sheet 7 so as to cover the microneedles 2 (see FIG. 10C). Next, the separator film 5b, the adhesive layer 5, and the sheet-like substrate 4 are punched into the outer shape of the microneedle sheet to form a cut 5a (see FIG. 10D). Next, the separator film 5b, the unnecessary adhesive layer 5 and the sheet-like substrate 4 are peeled off (see FIG. 11E). Next, the oil gel sheet 3 is bonded to the storage sheet 7 (see FIG. 11 (f)). A step due to the thickness of the sheet-like substrate 4 is formed on the surface of the oil gel sheet 3. Finally, the oil gel sheet 3 and the storage sheet 7 are punched into the outer shape of the microneedle patch 1 to obtain a package 6 of the microneedle patch (see FIG. 11G).
　なお、両面テープの代わりに片面テープを用いることもできる。片面テープの粘着面でない面にはエンボス加工を施し、図１０（ｃ）において、粘着面でない面をシート状基体４に貼り合わせる場合は、原料液２ａが完全に乾燥していない状態で貼り合わせてから乾燥させるとよい。このようにすると、エンボス加工により表面積が増えているため、粘着面でなくてもシート状基体４と粘着層５とを密着させることができる。また、粘着面をシート状基体４に貼り合わせる場合は、エンボス加工を施した面とオイルゲルシート３とを密着させることができる。 In addition, a single-sided tape can be used instead of the double-sided tape. When the non-adhesive surface of the single-sided tape is embossed, and the non-adhesive surface is bonded to the sheet-like substrate 4 in FIG. 10C, the raw material liquid 2a is not completely dried. It is better to dry it. If it does in this way, since the surface area increases by embossing, even if it is not an adhesive surface, the sheet-like base | substrate 4 and the adhesion layer 5 can be stuck. When the adhesive surface is bonded to the sheet-like substrate 4, the embossed surface and the oil gel sheet 3 can be brought into close contact with each other.
　　１，２０：マイクロニードルパッチ
　　２，２１：微小針
　　２ａ　　：原料液
　　３　　　：オイルゲルシート
　　３ａ　　：周辺部
　　４，２２：シート状基体
　　５，２４：粘着層
　　５ａ　　：切れ目
　　５ｂ　　：セパレータフィルム
　　６　　　：マイクロニードルパッチの梱包体
　　７　　　：収納シート
　　８　　　：微小凹部
　　９　　　：収納部
　　１０　　：型
　　１０ａ　：凹部
　　１１　　：プレート
　　２５　　：基材
　　２６　　：粘着シート DESCRIPTION OF SYMBOLS 1,20: Microneedle patch 2,21: Microneedle 2a: Raw material liquid 3: Oil gel sheet 3a: Peripheral part 4,22: Sheet-like base material 5,24: Adhesive layer 5a: Cut 5b: Separator film 6: Microneedle patch 7: storage sheet 8: minute recess 9: storage section 10: mold 10a: recess 11: plate 25: base material 26: adhesive sheet

Claims (6)

  1. 　オイルゲルシートと、前記オイルゲルシートの周辺部を除いた領域に形成された複数の微小針とを備えた、マイクロニードルパッチ。 A microneedle patch comprising an oil gel sheet and a plurality of microneedles formed in a region excluding the peripheral part of the oil gel sheet.
  2. 　前記オイルゲルシートと複数の前記微小針との間であって複数の前記微小針が形成された領域にシート状基体をさらに備えた、請求項１に記載のマイクロニードルパッチ。 2. The microneedle patch according to claim 1, further comprising a sheet-like substrate in a region between the oil gel sheet and the plurality of microneedles where the plurality of microneedles are formed.
  3. 　複数の前記微小針の前記オイルゲルシートに対向する面に粘着層をさらに備えた、請求項１に記載のマイクロニードルパッチ。 The microneedle patch according to claim 1, further comprising an adhesive layer on a surface of the plurality of microneedles facing the oil gel sheet.
  4. 　前記シート状基体の前記オイルゲルシートに対向する面に粘着層をさらに備えた、請求項２に記載のマイクロニードルパッチ。 The microneedle patch according to claim 2, further comprising an adhesive layer on a surface of the sheet-like substrate facing the oil gel sheet.
  5. 　オイルゲルシートと、前記オイルゲルシートの周辺部を除いた領域に形成され前記オイルゲルシートに対向する面に粘着層が形成された複数の微小針とを備えたマイクロニードルパッチと、
    　前記オイルゲルシートの前記周辺部を覆い、複数の微小凹部が形成され複数の前記微小針が収納された収納部を有する収納シートとを備えた、マイクロニードルパッチの梱包体。     A microneedle patch comprising an oil gel sheet, and a plurality of microneedles formed in a region excluding the periphery of the oil gel sheet and having an adhesive layer formed on a surface facing the oil gel sheet;
    A package of a microneedle patch, comprising: a storage sheet that covers the peripheral portion of the oil gel sheet and has a storage portion in which a plurality of microrecesses are formed and a plurality of the microneedles are stored.
  6. 　オイルゲルシートと、前記オイルゲルシートの周辺部を除いた領域に形成された粘着層と、前記粘着層の上に前記粘着層と同形状で形成されたシート状基体と、前記シート状基体の上に形成された複数の微小針とを備えたマイクロニードルパッチと、
    　前記オイルゲルシートの前記周辺部を覆い、複数の微小凹部が形成され複数の前記微小針が収納された収納部を有する収納シートとを備えた、マイクロニードルパッチの梱包体。     An oil gel sheet, an adhesive layer formed in a region excluding the peripheral portion of the oil gel sheet, a sheet-like substrate formed in the same shape as the adhesive layer on the adhesive layer, and on the sheet-like substrate A microneedle patch comprising a plurality of microneedles formed;
    A package of a microneedle patch, comprising: a storage sheet that covers the peripheral portion of the oil gel sheet and has a storage portion in which a plurality of microrecesses are formed and a plurality of the microneedles are stored.
PCT/JP2018/007639 2017-05-30 2018-02-28 Microneedle patch and packing material for same WO2018220926A1 (en)

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