WO2018216003A1 - Non-invasive device and method for sensing respiratory parameters - Google Patents
Non-invasive device and method for sensing respiratory parameters Download PDFInfo
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- WO2018216003A1 WO2018216003A1 PCT/IL2018/050512 IL2018050512W WO2018216003A1 WO 2018216003 A1 WO2018216003 A1 WO 2018216003A1 IL 2018050512 W IL2018050512 W IL 2018050512W WO 2018216003 A1 WO2018216003 A1 WO 2018216003A1
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- sensor
- invasive device
- respiratory
- flow
- housing
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/087—Measuring breath flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/087—Measuring breath flow
- A61B5/0878—Measuring breath flow using temperature sensing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
- A61B5/6819—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
- A61B5/682—Mouth, e.g., oral cavity; tongue; Lips; Teeth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0242—Operational features adapted to measure environmental factors, e.g. temperature, pollution
- A61B2560/0247—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/04—Constructional details of apparatus
- A61B2560/0443—Modular apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/18—Shielding or protection of sensors from environmental influences, e.g. protection from mechanical damage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/22—Arrangements of medical sensors with cables or leads; Connectors or couplings specifically adapted for medical sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
Definitions
- Measurement of respiratory flow parameters is one of the tools for assessing the respiratory ability of a patient.
- the parameters may include: breath temperature, flow rate, volume, pressure, the amount of exhaled non-organic compounds (e.g., water/humidity, CO 2 , O 2 , etc.) and exhaled volatile organic compounds (VOCs), as well as respiratory function parameters that can be extracted from such measurements, for example respiratory rate, respiratory length and depth, apneas length, time of inhale and exhale and the like.
- Such measurements are done using either non-direct measurements or direct respiratory sensors that detect/measure/monitor the actual respiratory flow. In order for such direct sensors to operate effectively, the respiratory flow or at least portion of it (inhaled and/or exhaled) is required to pass in the vicinity of the sensors, to enable an interaction between the respiratory flow and the sensing element.
- Another known method involves devices that require mounting to the subject's face such that the sensors included in the devices are located in the respiratory flow.
- One example for such a device is direct capnography.
- This device is cumbersome and requires placing the sensors in a mask covering the subject's nostrils/mouth.
- Another example includes wearable sensors mounted to the subject for example, on face/head, in such way that the sensors are placed around nostrils and near the mouth.
- wearable sensors can be, but are not limited to, temperature, humidity, chemical, pressure and flow sensors.
- One of the main drawbacks of such wearable sensors is the requirement for precise placement and fine tuning of the sensors' position on the subject's face, in order to align the sensors with the respiratory flow.
- the alternative is to utilize cannula-like designs that place the sensors inside the subject's nostrils and directly in front of his mouth. This leads to a different drawback: the inconvenience to the subject due to the placement of foreign object in his/her nostrils and on his or her mouth.
- Another known method involves devices for capturing and transferring at least a portion of the respiratory flow from the respiratory orifices and transferring, via tubes, the portion of the respiratory flow to external sensors.
- the main drawback of these sensing devices is that they are not fully wearable and easily portable, because although the capturing and transferring device is wearable, the external sensor is usually large and heavy.
- Some embodiments of the invention may be directed to a non-invasive device for holding one or more respiratory sensors.
- the non-invasive device may include a housing anatomically shaped to be attached to a face of a subject in proximity to the respiratory orifices.
- the housing may include: one or more flow directing elements for directing at least a portion of the respiratory flow to one or more predetermined locations, such that, at least one of the predetermined locations may be configured to hold at least one sensor.
- “Non-invasive device” may mean that the device is not inserted into a respiratory orifice, does not otherwise obstruct a respiratory orifice, and/or is not sealed around a respiratory orifice
- each of the one or more flow directing elements may be or may include at least one open conduit.
- the one of the one or more open conduits for guiding the at least a portion of the respiratory flow may be detachably connectable to the housing and may be adapted to guide or direct respiratory flow from and to the mouth over the respiratory sensor.
- the one or more open conduits for guiding at least a portion of respiratory flow may be connected to the housing, in a manner that allows a first open conduit to be moved with respect to a second open conduit.
- the one or more flow directing elements may include a recess.
- each recess may be located at the predetermined location and the recess walls may encapsulate the at least one sensor from at least two sides, to prevent or limit physical access to the sensor.
- the one or more flow directing elements may be or may include at least one of: a flat surface, a curved surface, a pipe and a combination thereof.
- the one or more flow directing elements may be designed to form at least one of: a controlled environment and a controlled flow regime in proximity to the sensor.
- the housing may further include one or more connectors for connecting at least one of: heating and cooling elements.
- the housing may further include one or more cavities for holding at least one of: heating and cooling element.
- the housing may further include one or more channels for receiving at least one of: a heating element and a cooling element.
- the non-invasive device may further include a mounting mechanism for mounting the non-invasive device to the face of the subject.
- the non-invasive device may further include a channel to receive tubing for providing fluids.
- the non-invasive device may further include connecting elements for receiving one or more add-on devices.
- Some aspects of the invention may be related to a no n- invasive device for measuring one or more respiratory flow parameters, comprising: a first sensor for measuring one or more respiratory flow parameters and a housing anatomically shaped to be attached to a face of a subject in proximity to the respiratory orifices.
- the housing may include one or more flow directing elements for directing at least a portion of the respiratory flow to at least a first predetermined location, wherein the first predetermined location is configured to hold at least the first sensor.
- the non- invasive device may further include a second sensor and wherein the one or more flow directing elements are for directing at least a portion of the respiratory flow to at least a second predetermined location, wherein the second predetermined location is configured to hold the second sensor.
- the first sensor may be for measuring a first type of respiratory flow parameters and the second sensor may be for measuring a second type of respiratory flow parameters.
- the first sensor may be for measuring a first type of respiratory flow parameters at the first predetermined location and the second sensor may be for measuring the first type of respiratory flow parameters at the second predetermined location.
- Some embodiment of the invention may be related to a method of measuring one or more respiratory flow parameters.
- the method may include mounting a non-invasive device to a face of a subject.
- the non-invasive device may include at least one sensor for measuring one or more respiratory flow parameters; and a housing anatomically shaped to be attached to a face of a subject in proximity to the respiratory orifices.
- the housing may include one or more flow directing elements for directing at least a portion of the respiratory flow to at least a first predetermined location, wherein the first predetermined location is configured to hold the at least one sensor.
- the method may further include receiving measurements from the at least one sensor.
- the method may further include controlling at least one of heating and cooling element included in the non-invasive device, to control the environment in a vicinity to the at least one sensor.
- FIGs. 1A and IB are illustrations of back and front views of a non-invasive device for holding one or more sensors according to some embodiments of the invention
- FIG. 2 is an illustration of a non-invasive device for holding one or more sensors according to some embodiments of the invention
- FIG. 3 is an illustration of the non-invasive device for holding one or more sensors of Fig. 1 mounted to a face of a subject according to some embodiments of the invention
- FIG. 4 is a flowchart of a method of measuring one or more respiratory flow parameters according to some embodiments of the invention.
- Figs 5A and 5B are graphs presenting humidity and temperature measurements of the respiratory flow measured using a device according to some embodiments of the invention.
- Some aspects of the invention may be directed to a device for holding one or more respiratory sensors in proximity to a subject's respiratory orifices in order to allow accurate measurements of different parameters of the respiratory flow.
- the parameters may include both chemical and physical properties of the flow.
- the parameters may include, flow rate, temperature, volume, pressure, concentration of non-organic compounds (e.g., water/humidity, CO2, O2, etc.) and volatile organic compounds in the respiratory flow, and the like.
- Each of the parameters may be sensed using a designated sensor.
- One or more designated sensors may be placed in predetermined locations inside the device.
- the device may include one or more flow directing elements for directing the respiratory flow from the respiratory orifices towards the sensors.
- a device may allow simple mounting of the device to the face of any subject that does not require a unique placement of the device for each specific subject, while allowing highly accurate measurements to be taken by the sensors.
- the accuracy of the measurements may be due to the controlled environment and flow regimes formed by the directing elements in vicinity of the sensors.
- the no n- invasive device may allow directing of a relatively constant portion of the respiratory flow, in an amount sufficient for receiving measurements (readings) from a sensor, through the sensors, without the need to put a mask or other sealing around a subject's nostrils and mouth.
- the device may provide a controlled environment for the sensors that may allow receiving pf robust and repeatable measurements, as discussed below.
- measurements taken using the non-invasive device may also enable (at least partially) quantification of respiratory flow (inhale/exhale flow changes between different breaths), which is not possible with many current solutions. In comparison, only the masks (or other "sealed” methods) are able to provide such repeatable and robust conditions for the measurement and sample delivery.
- FIGs. 1A and IB are illustrations of front and back views of a non-invasive device 100 for holding one or more sensors according to some embodiments of the invention.
- Device 100 may include a housing 50 anatomically shaped to be attached or otherwise mounted to a face of a subject in proximity to the respiratory orifices.
- Housing 50 may include one or more flow directing elements 56 and/or 58 for directing at least a portion of the respiratory flow to one or more predetermined locations in the housing, for example, within flow directing elements 56 and/or 58 or at locations 52 and/or 54 in another example.
- One or more predetermined locations may be in any place in flow directing elements 56 and/or 58, for example, at the opening of flow directing elements 56 and/or 58, in any location on the walls of flow directing elements 56 and/or 58 and the like.
- each of the predetermined locations for example, locations 52 and/or 54, may be configured to hold at least one sensor.
- the predetermined locations may be determined by analyzing the flow pattern from the respiratory orifices through flow directing elements 56 and/or 58 to find the optimal/desired location for placing the sensors.
- device 100 may further include the at least one sensor (not illustrated) and any form of communication (not illustrated) for sending measurements taken by the at least one sensor to a controller.
- Housing 50 may include or may be made from any suitable material, such as various polymers, ceramics or metals or a combination of more than one material. Housing 50 may be shaped to cause minimal inconvenience to the subject, for example, by being placed external to the respiratory orifices and allowing the subject to eat, drink or the like while wearing device 100. Accordingly, housing 50 may be at most 10 cm wide by 15 cm length, for example, 3 cm by 5 cm, 3.5 cm by 4 cm, 6 cm by 6 cm and 7 cm by 7 cm.
- flow directing elements 56 and 58 may be designed to form at least a controlled environment and/or a controlled flow regime in proximity to the predetermined locations, for example, locations 52 and/or 54.
- controlled environment may refer to, for example, one or more of: repeatable flow patterns, substantially steady flow rates, substantially steady temperature levels, substantially steady humidity levels and the like.
- a controlled environment may permit receiving steady measurements from the sensors placed in predetermined locations 52 and 54.
- each flow directing element 56 and/or 58 may be or may include at least one open conduit (as illustrated) or may be or may include a fiat surface, a curved surface, a pipe and the like or a combination thereof.
- flow directing element 56 may be designed to guide at least a portion of the respiratory flow (e.g. , from/to the nose) over a sensor placed in a first predetermined location, for example, location 52.
- flow directing element 58 may be designed to guide at least a portion of the respiratory flow (e.g., from/to the mouth) over a sensor placed in a second predetermined location, for example, location 54.
- flow directing elements 58 for example, in the form of an open conduit or any other shape may be detachably connected to housing 50.
- flow directing elements 58 for example, in the form of an open conduit may be for guiding respiratory flow from and to the mouth over the respiratory sensor (as illustrated n Figs. 1A and IB).
- a portion 59 of housing 50 that includes flow directing elements 58 and predetermined location 54 may be detachably connectable to a portion 57 of housing 50.
- device 100 may include flow directing elements 56 and predetermined location 52, for example, when only measurements of the respiratory flow of the nose are required.
- portion 59 may be detachably connectable to portion 57 using any known way, for example, via a connecting element 60.
- Connecting element 60 may be, or may include at least one of: a hinge, a rail, a magnet and the like.
- one or more flow directing elements 58 may be connected to housing 50, in a manner that allows flow directing element 58 to be moved with respect to flow directing element 56.
- connecting element 60 may allow portion 59 to move (e.g., shift) or pivot around connecting element 60, from one side of the mouth to the other, for example, to allow the subject to eat or receive medications orally.
- each of one of the predetermined locations may be configured to hold at least two sensors. The two sensors may be either identical or different.
- three, four or more sensors may be located at the predetermined locations in flow directing elements 56 and/or 58.
- the predetermined locations for example, locations 52 and 54 or other locations may be determined by analyzing the flow pattern from the respiratory orifices through flow directing elements 56 and/or 58 to find the optimal location for placing the one or more sensors.
- the optimal location may be determined as the location at which at least a controlled environment and/or a controlled flow regime may occur during a continuous respiratory parameters measurement.
- the optimal/desired location may be determined also based on the type of the sensor to be located in the predetermined location and the required measurements to be taken by the sensor.
- the predetermined locations may be at any location in flow directing elements 56 and/or 58 determined based on an analysis of the flow pattern through the flow directing elements and the invention as a whole is not limited to predetermined locations 52 and 54, which are given as an example only.
- one or more flow directing elements 56 and/or 58 may include recesses, for example located at predetermined locations 52 and 54, as illustrated in Fig. 1 A.
- the recesses at locations 52 and 54 may be shaped to support at least one sensor.
- the recess at location 52 may be shaped to support a first type of sensor and recess at location 54 may be shaped to support a second type of sensor.
- both recesses may be shaped to support the same type of sensor.
- the recesses walls at locations 52 and 54 may encapsulate the at least one sensor from at least two sides, to prevent physical access to the sensor.
- housing 50 may be shaped such that sensors placed in predetermined locations 52 and/or 54 may be covered (as illustrated) while still allowing flow of air to reach the sensors.
- the cover may protect the sensor from unintentional movement or touch by the subject or a caregiver, protect the sensor from the subject's fluids, and the like.
- housing 50 may further be configured to receive or hold at least one of: heating and cooling elements (not illustrated).
- the at least one of: heating and cooling elements may be added to device 100 for maintaining a controlled environment in the vicinity of the sensors.
- the controlled environment may include a controlled temperature, a controlled condensation, controlled humidity and the like.
- housing 50 may include connectors (not illustrated) for connecting at least one of: heating and cooling elements to housing 50.
- housing 50 may include one or more cavities for holding heating and/or cooling element(s).
- the one or more cavities may be located within one or more flow directing elements 56 and/or 58 in proximity to the one or more predetermined locations 52 and/or 54.
- housing 50 may include one or more channels, for allowing a heating element such as a wire, and/or a cooling element, such as a pipe or Peltier device, to be threaded into housing 50.
- device 100 may include a mounting mechanism (not illustrated) for mounting device 100 to the subject's face.
- a mounting mechanism is given in Fig. 3.
- the mounting mechanism may include at least one of, but not limited to: magnets, glue, cords, strings, tubing, glasses- like frame mounting, clips, piercing, elastic bands and the like.
- Device 200 may include a housing 150.
- Housing 150 may include a single flow directing element 156 for guiding the respiratory flow from and to each nostril over a sensor located at predetermined location 152.
- Flow directing element 156 may include two open conduits and at least one predetermined location 152, for example, in the form of a recess.
- Device 200 may further include at least one sensor and a mounting element for mounting device 200 to the face of the subject.
- device 200 may include a housing anatomically shaped for attachment to a subject's face.
- Fig. 3 is an illustration of the non-invasive device for holding one or more sensors of Fig. 1 mounted to a face of a subject according to some embodiments of the invention.
- Device 100 may be mounted to the face of the subject in proximity to the respiratory orifices using a mounting element, such as for example, wires 250.
- wires 250 may be also be the electrical wires for transmitting the signals measured by the one or more sensors located in housing 50 to a controller.
- the mounting element may include at least one of: stickers, glue, cords, strings, and elastic bands.
- device 100 may include one or more additional connecting elements 240 for receiving one or more add-on devices.
- the add-on device may include one of: CO 2 sensor, CCVCh/other cannulas, mouth opener, temperature sensor, invasive endoscope, O 2 saturation sensor, a pulse rate sensor and the like.
- the add-on devices may be or may include a channel for receiving tubing for providing fluids.
- the channel may be at least one of: feeding tubes, 0 2 /air channels and the like.
- non-invasive devices 100 or 200 may further include a first sensor located at a first predetermined location, for example, location 52 or 152 or another first location for measuring one or more respiratory flow parameters.
- devices 100 or 200 may further include a second sensor located either at the first predetermined location, for example, location 52 or 152 or at a second predetermined location, for example, location 54 or another second location.
- the first sensor may be for measuring a first type of respiratory flow parameter (e.g., humidity) and the second sensor may be for measuring a second type of respiratory flow parameter (e.g., temperature).
- the first sensor may be for measuring a first type of respiratory flow parameter (e.g., humidity) at the first predetermined location (e.g., location 52) and the second sensor is for measuring the first type of respiratory flow parameter at the second predetermined location (e.g., location 54).
- the first sensor and/or the second sensor may be for measuring: breath's temperature, flow rate, volume, pressure, the amount of non-organic compounds in the breath (e.g., water/humidity, CO2, O2, etc.), the amount of volatile organic compounds exhaled from the breath and the like.
- FIG. 4 is a flowchart of a method of measuring one or more respiratory flow parameters according to some embodiments of the invention.
- a non-invasive device such as device 100 or 200 may be mounted to a face of a subject (as illustrated in Fig. 3), in box 410.
- Device 100 or 200 may include a housing 50 or 150 anatomically shaped to be attached to a face of any subject in proximity to the respiratory orifices and at least one sensor for measuring the respiratory flow parameters.
- Each of the sensors may be held in a predetermined location (e.g., locations 52, 54 or 152 or 56 or 58) at one or more flow directing elements (e.g., flow directing elements 56, 58 or 156) for directing at least a portion of the respiratory flow to at least a first predetermined location.
- a predetermined location e.g., locations 52, 54 or 152 or 56 or 58
- flow directing elements e.g., flow directing elements 56, 58 or 156
- measurements of respiratory parameters may be received from the at least one sensor, in box 420.
- the respiratory parameters may include: breath temperature, flow rate, volume, pressure, the amount of non-organic compounds in the breath (e.g., water/humidity, CO 2 , O 2 , etc.), the amount of volatile organic compounds exhaled from the breath and the like.
- a controller being in communication with the at least one sensor may receive the measurements and may further process and display the measurements on a display. Examples, for displayed measurements are given in Figs. 5A and 5B.
- Figs. 5A and 5B are graphs of measurements of response to humidity sensor in Ohms (Fig. 5A) and response to temperature sensor in Volts (Fig. 5B) of the respiratory flow of a subject measured by temperature and humidity sensors held in a device, such as device 100.
- the graphs show steady repeatable measurements during both the inhale and exhale stages.
- Some embodiments of the method may further include heating and/or cooling the environment in the vicinity to the at least one sensor for maintaining a controlled environment.
- the controlled environment may include a controlled temperature, a controlled condensation, a controlled humidity and the like.
- cooling and/or heating elements attached, held, threaded to the like, into housing 50 may be activated (e.g., by the controller) to form the controlled environment.
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Abstract
Description
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Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
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CN201880034401.5A CN110785124A (en) | 2017-05-25 | 2018-05-10 | Non-invasive apparatus and method for sensing respiratory parameters |
US16/616,512 US20210145312A1 (en) | 2017-05-25 | 2018-05-10 | Non-invasive device and method for sensing respiratory parameters |
KR1020197038009A KR20200011468A (en) | 2017-05-25 | 2018-05-10 | Non-Invasive Devices and Methods for Detecting Respiratory Parameters |
CA3064505A CA3064505A1 (en) | 2017-05-25 | 2018-05-10 | Non-invasive device and method for sensing respiratory parameters |
JP2019565418A JP2020520767A (en) | 2017-05-25 | 2018-05-10 | Non-invasive device and method for sensing respiratory parameters |
EP18805408.4A EP3629918A4 (en) | 2017-05-25 | 2018-05-10 | Non-invasive device and method for sensing respiratory parameters |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US15/604,866 US20180338706A1 (en) | 2017-05-25 | 2017-05-25 | Non-invasive device and method for sensing respiratory parameters |
US15/604,866 | 2017-05-25 |
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WO2018216003A1 true WO2018216003A1 (en) | 2018-11-29 |
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PCT/IL2018/050512 WO2018216003A1 (en) | 2017-05-25 | 2018-05-10 | Non-invasive device and method for sensing respiratory parameters |
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US (2) | US20180338706A1 (en) |
EP (1) | EP3629918A4 (en) |
JP (1) | JP2020520767A (en) |
KR (1) | KR20200011468A (en) |
CN (1) | CN110785124A (en) |
CA (1) | CA3064505A1 (en) |
WO (1) | WO2018216003A1 (en) |
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US11600365B2 (en) | 2017-12-12 | 2023-03-07 | Vyaire Medical, Inc. | Nasal and oral respiration sensor |
WO2020252067A1 (en) | 2019-06-11 | 2020-12-17 | Vyaire Medical, Inc. | Respiration sensor attachment device |
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- 2018-05-10 CN CN201880034401.5A patent/CN110785124A/en active Pending
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- 2018-05-10 US US16/616,512 patent/US20210145312A1/en not_active Abandoned
- 2018-05-10 CA CA3064505A patent/CA3064505A1/en not_active Abandoned
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CN110785124A (en) | 2020-02-11 |
EP3629918A1 (en) | 2020-04-08 |
KR20200011468A (en) | 2020-02-03 |
JP2020520767A (en) | 2020-07-16 |
US20210145312A1 (en) | 2021-05-20 |
US20180338706A1 (en) | 2018-11-29 |
EP3629918A4 (en) | 2020-12-23 |
CA3064505A1 (en) | 2018-11-29 |
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