WO2018198403A1 - Dispositif d'inspection, machine d'emballage ptp et procédé de production de feuille ptp - Google Patents

Dispositif d'inspection, machine d'emballage ptp et procédé de production de feuille ptp Download PDF

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Publication number
WO2018198403A1
WO2018198403A1 PCT/JP2017/037652 JP2017037652W WO2018198403A1 WO 2018198403 A1 WO2018198403 A1 WO 2018198403A1 JP 2017037652 W JP2017037652 W JP 2017037652W WO 2018198403 A1 WO2018198403 A1 WO 2018198403A1
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WO
WIPO (PCT)
Prior art keywords
imaging
inspection
film
ptp
pocket portion
Prior art date
Application number
PCT/JP2017/037652
Other languages
English (en)
Japanese (ja)
Inventor
田口　幸弘
大山　剛
憲彦 坂井田
Original Assignee
Ckd株式会社
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Application filed by Ckd株式会社 filed Critical Ckd株式会社
Publication of WO2018198403A1 publication Critical patent/WO2018198403A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B57/00—Automatic control, checking, warning, or safety devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B57/00—Automatic control, checking, warning, or safety devices
    • B65B57/10—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of articles or materials to be packaged
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B9/00—Enclosing successive articles, or quantities of material, e.g. liquids or semiliquids, in flat, folded, or tubular webs of flexible sheet material; Subdividing filled flexible tubes to form packages
    • B65B9/02—Enclosing successive articles, or quantities of material between opposed webs
    • B65B9/04—Enclosing successive articles, or quantities of material between opposed webs one or both webs being formed with pockets for the reception of the articles, or of the quantities of material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids

Definitions

  • the present invention relates to an inspection apparatus, a PTP packaging machine, and a method for manufacturing a PTP sheet that inspect for mixing of different varieties using spectroscopic analysis.
  • a PTP sheet is composed of a container film in which a pocket portion filled with an object such as a tablet is formed, and a cover film that is attached to the container film so as to seal the opening side of the pocket portion.
  • near infrared light H 1 is applied to the object 83 filled in the pocket portion 82 of the container film 81 in the process of manufacturing the PTP sheet.
  • the reflected light H 2 reflected from the object 83 or the like is collected by the optical lens 85 to become parallel light H 3 .
  • the light that has passed through the slit 86 becomes strip-shaped slit light H 4 and enters a spectroscope (prism) 87.
  • the slit light H 4 incident on the spectroscope 87 is split into light of each wavelength component and projected as a spectral spectrum (spectral spectrum image) H S on the light receiving surface 89 of the image sensor 88.
  • spectral spectrum H S spectral spectrum image
  • each wavelength component of the spectral spectrum H S is projected to a different position on the light receiving surface 89 of the image sensor 88 due to the difference in the wavelength component.
  • the spectral data obtained by imaging the spectral spectrum H S is subjected to principal component analysis to detect mixing of different varieties.
  • CMOS Complementary Metal Oxide Semiconductor
  • an interline transfer type CCD area sensor is two-dimensionally arranged in a matrix, and converts a plurality of light receiving portions (pixels) that accumulate incident light into charges corresponding to the amount of light, and the light receiving portions that are stored in the light receiving portions.
  • a plurality of vertical transfer units for transferring charges in the vertical direction
  • a horizontal transfer unit for transferring charges transferred from the vertical transfer unit in the horizontal direction
  • an area sensor that divides the light receiving surface into two regions and outputs from the two regions in parallel from different channels is used. It is conceivable to increase the acquisition speed (see, for example, Patent Document 2).
  • the output amplifier is different for each channel. For this reason, the gains of the respective channels cannot be completely matched due to variations in the characteristics of the respective amplifiers, and there is a possibility that the output levels of the respective channels may vary. As a result, when an imaging device having a plurality of output channels is used in an inspection apparatus using spectroscopic analysis, spectrum data may not be acquired appropriately.
  • a light receiving surface 89 is divided into two light receiving areas 89A and 89B, and outputs from the two light receiving areas 89A and 89B are performed in parallel from different output channels CH1 and CH2, respectively.
  • a case where an image sensor is used will be described as an example (see FIG. 18).
  • FIG. 18 is reflected by the object 83 filled with respect to each of the five pocket portions 82 formed at predetermined intervals in the film width direction (Y direction) orthogonal to the transport direction (X direction) of the container film 81.
  • FIG. 6 is a schematic diagram showing a state in which a spectral spectrum H S of projected light is projected onto a light receiving surface 89 of an image sensor 88.
  • FIG. 18 for the sake of convenience, only the spectral spectra H S related to the five objects 83 are shown, and the spectral spectra related to other parts (the container film 3 and the like) are not shown.
  • a demarcation line (a boundary between the first light receiving region 89A and the second light receiving region 89B) 89C that divides the light receiving surface 89 into two light receiving regions 89A and 89B is projected onto the light receiving surface 89.
  • the image sensor 88 is arranged so as to intersect with the wavelength dispersion direction (X direction) of the spectral spectrum H S to be transmitted, for example, the wavelength component on the long wavelength side among all the wavelength components of the spectral spectrum H S Is picked up in the first light receiving region 89A, and the wavelength component on the short wavelength side is picked up in the second light receiving region 89B.
  • the spectrum H S according to the predetermined position on the object 83 (a predetermined coordinate point) will between partitioned line 89C, the strength data of all wavelength components of the spectroscopic spectrum H S from the same channel of the image sensor 88 It can no longer be acquired. As a result, there is a possibility that spectrum data relating to a predetermined position on the object 83 cannot be acquired properly, and the inspection accuracy is lowered.
  • the present invention has been made in view of the above circumstances, and an object of the present invention is to increase the speed of inspection for mixing different types of products using spectroscopic analysis, and an inspection apparatus and PTP packaging that can suppress a decrease in inspection accuracy. It is in providing the manufacturing method of an apparatus and a PTP sheet.
  • Irradiating means capable of irradiating near-infrared light to the object;
  • a spectroscopic means capable of spectroscopically reflecting the reflected light reflected from the object irradiated with the near infrared light;
  • An imaging unit capable of imaging a spectral spectrum (spectral spectrum image) related to the reflected light spectrally separated by the spectral unit;
  • Spectral data acquisition means capable of acquiring spectral data based on the spectral spectrum imaged by the imaging means;
  • An analysis means capable of detecting different varieties by performing a predetermined analysis process (for example, principal component analysis) based on the spectrum data;
  • the imaging means includes The light receiving surface is divided into a plurality of areas, and includes an image sensor that performs output from the plurality of divided areas in parallel from different channels, A partition line (a boundary portion of the plurality of regions) that partitions the plurality of regions is arranged so as to be along (in parallel with) the wavelength dispersion direction of the spectral spectrum
  • the imaging means according to the means 1 has a configuration in which the light receiving surface (light receiving area) of the imaging element is partitioned into a plurality of areas, and outputs from the partitioned areas are performed in parallel from different channels. .
  • the imaging speed (spectrum data acquisition speed)
  • the image pickup means has a configuration in which a dividing line that divides the light receiving surface of the image sensor into a plurality of regions is arranged along the wavelength dispersion direction of the spectral spectrum projected on the light receiving surface. Yes.
  • the intensity data of all the wavelength components of the spectral spectrum concerning the predetermined position (predetermined coordinate point) on the object can be acquired from the same channel of the image sensor.
  • the degree of parallelism between the “compartment line” and the “wavelength dispersion direction of the spectral spectrum” is at least “partition line (at least part thereof)” and “spectral spectrum related to the object” on the light receiving surface of the image sensor. As long as it does not overlap. That is, both need only be in a “substantially parallel” state, and may not be in a strict “parallel” state.
  • Means 2 comprising an imaging position adjusting means capable of adjusting a position of the imaging means so that a spectral spectrum related to the object and the partition line do not overlap on a light receiving surface of the imaging element. The inspection device described.
  • average spectral data is calculated based on spectral data at a plurality of positions acquired from different channels. Therefore, there is a possibility that the average spectrum data of the target cannot be acquired appropriately.
  • the average spectrum data of the object can be calculated based on the spectrum data at a plurality of positions acquired from the same channel, it is possible to suppress a decrease in inspection accuracy.
  • a PTP wrapping machine for manufacturing a PTP sheet in which an object is stored in a pocket portion formed in a container film, and a cover film is attached so as to close the pocket portion, Pocket portion forming means for forming the pocket portion with respect to the container film transported in a strip shape; Filling means for filling the pocket with the object; Attaching means for attaching the band-shaped cover film so as to close the pocket portion with respect to the container film filled with the object in the pocket portion, Separating means for separating the PTP sheet from a strip-shaped body (band-shaped PTP film) in which the cover film is attached to the container film (including punching means for punching in units of sheets); A PTP packaging machine comprising the inspection device according to the above means 1 or 2.
  • the PTP packaging machine may include a discharge unit that discharges the PTP sheet that is determined to be defective by the inspection apparatus.
  • the said means 3 it is good also as a structure which has arrange
  • the inspection apparatus may be arranged in “a post-process in which an object is filled in the pocket portion by the filling means and a pre-process in which the cover film is attached by the attaching means”. In such a case, the inspection can be executed in a state where there is nothing to block the object, and the inspection accuracy can be further improved.
  • the inspection apparatus may be arranged in a “post-process after the cover film is attached by the attaching means and a pre-process where the PTP sheet is separated by the separating means”. In such a case, the inspection can be performed in a state where the object is not replaced, and the inspection accuracy can be further improved.
  • the inspection apparatus may be arranged in “the post-process after the PTP sheet is separated by the separating means”. In such a case, it can be confirmed at the final stage whether defective products are mixed.
  • Means 4 A method for producing a PTP sheet for producing a PTP sheet in which an object is accommodated in a pocket portion formed in a container film and a cover film is attached so as to close the pocket portion, A pocket portion forming step for forming the pocket portion with respect to the container film transported in a strip shape; A filling step of filling the pocket with the object; An attachment step of attaching the band-shaped cover film so as to close the pocket portion, with respect to the container film filled with the object in the pocket portion, A separation step (including a punching step of punching in units of sheets) for separating the PTP sheet from a strip-shaped body (band-shaped PTP film) in which the cover film is attached to the container film; And an inspection process for inspecting the mixing of different varieties, In the inspection step, An irradiation step of irradiating the object with near infrared light; A spectroscopic step of spectroscopically reflecting the reflected light reflected from the object irradiated with the near-infrared light
  • the means 4 may be configured to perform the inspection step as a “pre-filling step”. In such a case, it is possible to eliminate different varieties at the stage prior to filling the pocket portion, and to reduce PTP sheets that are defective.
  • the inspection process may be performed as “a post process of the filling process and a pre process of the attachment process”. In such a case, the inspection can be executed in a state where there is nothing to block the object, and the inspection accuracy can be improved.
  • the inspection process may be performed as “a post process of the attachment process and a pre process of the separation process”. In such a case, the inspection can be executed in a state where the object is not replaced, and the inspection accuracy can be improved.
  • the above inspection process may be performed as a “post process of the separation process”. In such a case, it can be confirmed at the final stage whether defective products are mixed.
  • Means 5 comprising an imaging position adjustment step of adjusting the position of the imaging means so that a spectral spectrum related to the object and the partition line do not overlap on the light receiving surface of the imaging element. Manufacturing method of PTP sheet.
  • (A) is a perspective view which shows a PTP sheet
  • (b) is a perspective view which shows a PTP film. It is a partial expanded sectional view of the pocket part of a PTP sheet.
  • FIG. 1 It is a schematic diagram which shows an example of the state which irradiated the center reference line (line light) with respect to the container film in an imaging position adjustment process, Comprising: (a) is a figure which shows the state in which the center reference line overlapped with the pocket part area
  • the PTP sheet 1 has a container film 3 having a plurality of pocket portions 2 and a cover film 4 attached to the container film 3 so as to close the pocket portions 2. ing.
  • Each pocket 2 stores one tablet 5 as an object.
  • the container film 3 in the present embodiment is formed of a transparent thermoplastic resin material such as PP (polypropylene) or PVC (polyvinyl chloride), and has translucency.
  • the cover film 4 is made of an opaque material (for example, an aluminum foil) provided with a sealant made of, for example, polypropylene resin on the surface.
  • the PTP sheet 1 is formed by punching a belt-like PTP film 6 [see FIG. 1B] formed from the belt-like container film 3 and the belt-like cover film 4 into a sheet shape. Manufactured.
  • the raw material of the strip-shaped container film 3 is wound in a roll shape.
  • the drawer end side of the container film 3 wound in a roll shape is guided by a guide roll 13.
  • the container film 3 is hooked on the intermittent feed roll 14 on the downstream side of the guide roll 13.
  • the intermittent feed roll 14 is connected to a motor that rotates intermittently and transports the container film 3 intermittently.
  • a heating device 15 and a pocket portion forming device 16 are arranged in this order along the conveyance path of the container film 3. And in the state which the container film 3 was heated with the heating apparatus 15 and this container film 3 became comparatively flexible, the several pocket part 2 is shape
  • the heating device 15 and the pocket portion forming device 16 constitute the pocket portion forming means in this embodiment.
  • the pocket portion 2 is formed during an interval between the container film 3 transport operations by the intermittent feed roll 14.
  • the container film 3 fed from the intermittent feed roll 14 is hung in the order of a tension roll 18, a guide roll 19, and a film receiving roll 20. Since the film receiving roll 20 is connected to a motor that rotates at a constant speed, the container film 3 is transported continuously and at a constant speed.
  • the tension roll 18 is in a state in which the container film 3 is pulled to the side where the container film 3 is tensioned by an elastic force, and prevents the container film 3 from being bent due to the difference in the transport operation between the intermittent feed roll 14 and the film receiving roll 20.
  • the container film 3 is always kept in a tension state.
  • a tablet filling device 21 is disposed between the guide roll 19 and the film receiving roll 20 along the conveyance path of the container film 3.
  • the tablet filling device 21 has a function as a filling means for automatically filling the tablet 5 in the pocket portion 2.
  • the tablet filling device 21 is configured to drop the tablets 5 by opening the shutter at predetermined intervals in synchronization with the transport operation of the container film 3 by the film receiving roll 20, and each pocket portion is accompanied by the shutter opening operation. 2 is filled with the tablet 5 (filling step).
  • An inspection device 22 is disposed between the tablet filling device 21 and the film receiving roll 20 along the conveyance path of the container film 3.
  • the inspection apparatus 22 is an inspection apparatus that performs inspection using spectroscopic analysis, and is for inspecting mixing of different varieties. Details of the inspection device 22 will be described later.
  • the raw material of the cover film 4 formed in a strip shape is wound in a roll shape on the most upstream side.
  • the drawn end of the cover film 4 wound in a roll shape is guided by the guide roll 24 and guided toward the heating roll 25.
  • the heating roll 25 can be pressed against the film receiving roll 20, and the container film 3 and the cover film 4 are fed between the rolls 20 and 25.
  • the container film 3 and the cover film 4 pass between both the rolls 20 and 25 in a heating-pressing state, the cover film 4 is stuck to the container film 3, and the pocket part 2 is block
  • the PTP film 6 as a strip
  • fine mesh-like ridges for sealing are formed, and a strong seal is realized by strongly pressing them.
  • the film receiving roll 20 and the heating roll 25 constitute the attachment means in this embodiment.
  • the PTP film 6 sent out from the film receiving roll 20 is hung in the order of the tension roll 27 and the intermittent feed roll 28. Since the intermittent feed roll 28 is connected to a motor that rotates intermittently, the PTP film 6 is intermittently conveyed.
  • the tension roll 27 is in a state in which the PTP film 6 is pulled toward the side to be tensioned by the elastic force, and prevents the PTP film 6 from being bent due to the difference in the transport operation between the film receiving roll 20 and the intermittent feed roll 28.
  • the PTP film 6 is always kept in tension.
  • the PTP film 6 sent out from the intermittent feed roll 28 is hooked in the order of the tension roll 31 and the intermittent feed roll 32. Since the intermittent feed roll 32 is connected to an intermittently rotating motor, the PTP film 6 is intermittently conveyed.
  • the tension roll 31 is in a state in which the PTP film 6 is pulled toward the side to be tensioned by an elastic force, and prevents the PTP film 6 from being bent between the intermittent feed rolls 28 and 32.
  • a slit forming device 33 and a marking device 34 are sequentially arranged along the transport path of the PTP film 6.
  • the slit forming device 33 has a function of forming a slit for separation at a predetermined position of the PTP film 6.
  • the marking device 34 has a function of marking a predetermined position (for example, a tag portion) of the PTP film 6.
  • the PTP film 6 fed from the intermittent feed roll 32 is hooked in the order of the tension roll 35 and the continuous feed roll 36 on the downstream side.
  • a sheet punching device 37 is disposed between the intermittent feed roll 32 and the tension roll 35 along the transport path of the PTP film 6.
  • the sheet punching device 37 has a function as sheet punching means (cutting means) for punching the outer edge of the PTP film 6 in units of one PTP sheet.
  • the PTP sheet 1 punched by the sheet punching device 37 is transported by the take-out conveyor 39 and temporarily stored in the finished product hopper 40 (separation process).
  • the inspection device 22 determines that the product is defective
  • the PTP sheet 1 determined to be defective is separately discharged by a defective sheet discharge mechanism (not shown) as discharge means.
  • a cutting device 41 is disposed downstream of the continuous feed roll 36. Then, the unnecessary film portion 42 constituting the remaining material portion (scrap portion) remaining in a strip shape after being punched by the sheet punching device 37 is guided to the tension roll 35 and the continuous feed roll 36 and then guided to the cutting device 41. It is burned.
  • the continuous feed roll 36 is in pressure contact with a driven roll, and performs a conveying operation while sandwiching the unnecessary film portion 42.
  • the cutting device 41 has a function of cutting the unnecessary film portion 42 into a predetermined size and scrapping. The scrap is stored in the scrap hopper 43 and then disposed of separately.
  • the rolls 14, 20, 28, 31, 32 and the like have a positional relationship in which the roll surface and the pocket portion 2 face each other, but the pocket portion 2 is formed on the surface of the intermittent feed roll 14 or the like. Since the recessed part accommodated is formed, the pocket part 2 is not crushed. Further, the feeding operation is performed while the pocket portion 2 is accommodated in each recess such as the intermittent feeding roll 14, so that the intermittent feeding operation and the continuous feeding operation are reliably performed.
  • FIG. 4 is a block diagram showing an electrical configuration of the inspection apparatus 22
  • FIG. 5 is a perspective view schematically showing an arrangement configuration of the inspection apparatus 22. As shown in FIG.
  • the inspection device 22 performs various controls, image processing, calculation processing, and the like in the inspection device 22 such as drive control of the illumination device 52, the imaging device 53, the illumination device 52 and the imaging device 53. And a control processing device 54 to be implemented.
  • the illumination device 52 and the imaging device 53 are arranged on the pocket portion 2 opening side of the container film 3. That is, in this embodiment, a different kind mixing inspection is performed from the pocket part 2 opening side of the container film 3 in the stage before the cover film 4 is attached.
  • the illumination device 52 is a known device configured to be able to irradiate near-infrared light, and constitutes an irradiation means in the present embodiment.
  • the illuminating device 52 is arrange
  • a halogen lamp is employed as a light source capable of emitting near-infrared light having a continuous spectrum (for example, a near-infrared region having a wavelength of 700 to 2500 nm).
  • a deuterium discharge tube, a tungsten lamp, a xenon lamp, or the like can be used as the light source.
  • the imaging device 53 (main body 53a) includes an optical lens 61, a two-dimensional spectroscope 62 as a spectral means, and a camera 63 as an imaging means.
  • the optical lens 61 is composed of a plurality of lenses (not shown) and the like, and is configured so that incident light can be collimated.
  • the optical axis of the optical lens 61 is set along the vertical direction (Z direction).
  • the optical lens 61 is set so that incident light can be imaged at a position of a slit 62a of a two-dimensional spectrometer 62 described later.
  • a double-sided telecentric lens is adopted as the optical lens 61 is shown, but an image-side telecentric lens may naturally be used.
  • the two-dimensional spectroscope 62 includes a slit 62a, an incident side lens 62b, a spectroscopic unit 62c, and an output side lens 62d.
  • the spectroscopic unit 62c includes an incident side prism 62ca, a transmissive diffraction grating 62cb, and an output side prism 62cc.
  • the light that has passed through the slit 62a is collimated by the incident side lens 62b, then dispersed by the spectroscopic unit 62c, and is output to the image sensor 64 of the camera 63, which will be described later, by the output side lens 62d.
  • An image is formed as (spectral spectrum H s ) (see FIG. 12).
  • the slit 62a is formed in an elongated and substantially rectangular shape (line shape), its width direction (short direction) is disposed along the film transport direction (X direction) of the container film 3, and its longitudinal direction is the transport direction. It arrange
  • the camera 63 includes, as the image sensor 64, an interline transfer type CCD area sensor having sufficient sensitivity for a wavelength range of, for example, a wavelength of 900 to 1700 nm in the near infrared region.
  • the image sensor (CCD area sensor) 64 is a two-dimensional array arranged in a matrix, and includes a photoelectric conversion element (for example, a photodiode) that converts incident light into electric charge corresponding to the amount of light and accumulates it.
  • a plurality of light receiving portions (pixels) 65 are provided corresponding to each vertical column of the light receiving portions 65, and charges accumulated in the light receiving portions 65 of the vertical columns are equivalent to one row (for one pixel) in the vertical direction.
  • an output amplifier 68 that converts the electric charge transferred from the horizontal transfer section 67 into a voltage, amplifies it, and outputs it.
  • the image sensor (CCD area sensor) 64 in the present embodiment is arranged such that its horizontal direction is along the film transport direction (X direction) and its vertical direction is along the film width direction (Y direction). Yes.
  • the image sensor (CCD area sensor) 64 has a light receiving surface (light receiving area) 69 for one screen divided into two in the vertical direction (Y direction). The output from the two divided (partitioned) areas is performed in parallel from two different channels.
  • the charges read from the light receiving unit 65 included in the first light receiving region 69A located on the upper side of FIG. 7 are transferred to the first output on the upper side of FIG. 7 via the first horizontal transfer unit 67A on the upper side of FIG. Output from the amplifier 68A.
  • Such an output path is the first channel CH1.
  • the image signals (spectral image data) output from both channels CH1 and CH2 are image signals (spectral image) for one screen imaged by the entire light receiving surface (light receiving region) 69 via a circuit (not shown). Data) and converted into a digital signal, and then output from the camera 63 to the control processing device 54.
  • the visual field region of the imaging device 53 is a linear region extending along the film width direction (Y direction) and includes at least the entire region of the container film 3 in the film width direction (see the two-dot chain line portion in FIG. 5). ).
  • the visual field area of the imaging device 53 in the film transport direction (X direction) is an area corresponding to the width of the slit 62a. That is, this is a region where the light (slit light) that has passed through the slit 62 a forms an image on the light receiving surface 69 of the image sensor 64.
  • each light receiving portion (pixel) 65 of the imaging element 64 receives each wavelength component of the spectral spectrum H S of the reflected light reflected at each position in the film width direction (Y direction) of the container film 3.
  • a signal corresponding to the intensity of light received by each light receiving unit 65 is output to the control processing device 54.
  • the imaging device 53 includes an imaging position adjustment mechanism (imaging position adjustment means) 55 that can adjust the imaging position.
  • the imaging position adjusting mechanism 55 includes a Z-axis moving mechanism 56 for sliding the imaging device 53 (main body 53a) along the vertical direction (Z direction) that is the normal direction of the container film 3, and the Z-axis movement.
  • the operator can adjust the imaging position and the visual field area of the imaging device 53.
  • the control processing device 54 is an input device 72 as “input means” composed of a CPU and an input / output interface 71 (hereinafter referred to as “CPU etc. 71”), a keyboard, a mouse, a touch panel, etc.
  • a display device 73 as a “display unit” having a display screen such as a CRT or a liquid crystal, an image data storage device 74 for storing various image data, an arithmetic result storage device 75 for storing various arithmetic results,
  • a setting data storage device 76 for storing various kinds of information in advance is provided. These devices 72 to 76 are electrically connected to the CPU 71 or the like.
  • the CPU 71 is connected to the PTP packaging machine 10 so that various signals can be transmitted and received. Thereby, for example, the defective sheet discharge mechanism of the PTP packaging machine 10 can be controlled.
  • the image data storage device 74 includes spectral image data captured by the imaging device 53, spectral image data acquired based on the spectral image data, binarized image data after binarization processing, and after differential processing. This is for storing differential image data and the like.
  • the operation result storage device 75 stores inspection result data, statistical data obtained by probabilistically processing the inspection result data, and the like. These inspection result data and statistical data can be appropriately displayed on the display device 73.
  • the setting data storage device 76 stores, for example, loading vectors and determination ranges used for principal component analysis, shapes and dimensions of the PTP sheet 1, the pocket portion 2, and the tablet 5.
  • the imaging position adjustment step is performed in a state in which the conveyance of the container film 3 is stopped and the line light R as a central reference line is irradiated on the container film 3 [FIGS. 9A and 9B]. reference ⁇ .
  • the center reference line (line light R) is a dividing line that divides the light receiving surface 69 of the image sensor 64 into a first light receiving region 69A and a second light receiving region 69B (the boundary between the first light receiving region 69A and the second light receiving region 69B).
  • the operator adjusts the position of the imaging device 53 by operating the input device 72 and the like while visually checking the central reference line (line light R) irradiated on the container film 3.
  • center reference line line light R
  • the operator moves the imaging device 53 in the film width direction (Y direction).
  • the central reference line does not overlap the pocket portion 2 (see FIG. 9B).
  • the partition line 69C between the two light receiving areas 69A and 69B and the spectral spectrum H S related to the tablet 5 in the pocket portion 2 overlap. (See FIG. 12).
  • FIG. 12 is a schematic diagram showing a state in which the spectral spectrum H S of the reflected light reflected at a predetermined position on the tablet 5 is projected onto the light receiving surface 69 of the image sensor 64. 12, for convenience, illustrated only spectrum H S of the tablet 5, for spectrum according to another site (container film 3 and the like) are omitted.
  • This routine is a process that is repeatedly executed every time the container film 3 is conveyed by a predetermined amount.
  • step S01 first, the control processing device 54 irradiates near-infrared light from the illumination device 52 to the continuously transported container film 3 (tablet 5) (irradiation process), while the imaging processing (exposure processing) by the imaging device 53 is performed. ).
  • control processing device 54 drives and controls the imaging device 53 based on a signal from an encoder (not shown) provided in the PTP packaging machine 10, and spectral image data captured by the imaging device 53 is stored in an image data storage device 74. Into.
  • the conveyance direction imaging range D (refer FIG. 11) during the execution period (exposure period) of the imaging process of step S01.
  • the reflected light is incident on the imaging device 53. That is, the conveyance direction imaging range D is imaged by one imaging process.
  • the reflected light incident on the imaging device 53 is dispersed by the two-dimensional spectroscope 62 (spectral process), and captured as a spectral image (spectral spectrum H S ) by the imaging device 64 of the camera 63 (imaging process).
  • the imaging device 64 of the camera 63 imaging process
  • the container film 3 tablette 5
  • the execution period exposure period
  • the averaged spectral spectrum H S in the conveyance direction imaging range D is captured here. Will be.
  • the dividing line 69C between the light receiving regions 69A and 69B is the film transport direction (X direction), that is, the wavelength of the spectral spectrum H S projected onto the light receiving surface 69. It arrange
  • the intensity data of all the wavelength components of the spectral spectrum H S relating to a predetermined position on the tablet 5 can be acquired from the same channel of the image sensor 64.
  • Spectral image (spectral spectrum H s ) data captured by the imaging device 53 is output to the control processing device 54 during the interval and stored in the image data storage device 74.
  • the interval period referred to here is a period for reading image data. That is, the imaging cycle by the imaging device 53 can be represented by the total time of the exposure period and the interval period, which are the execution period of the imaging process.
  • control processing device 54 starts the data generation process in step S02.
  • spectrum data is generated based on the spectral image data acquired in step S01.
  • the spectrum data is stored in the image data storage device 74, and this routine is terminated once.
  • This process corresponds to the spectrum data acquisition process in the present embodiment, and the spectrum data acquisition means in the present embodiment is configured by the processing function of the control processing device 54 that executes the process.
  • the transport direction imaging range D is intermittently relatively moved, and the spectrum data acquisition routine is repeated.
  • the image data storage device 74 the spectral data corresponding to each conveyance direction imaging range D is sequentially stored in time series together with the position information in the film width direction. As a result, a two-dimensional spectrum image G having spectrum data for each pixel is generated (see FIG. 13).
  • the spectrum image G is image data in which a plurality of pixels Ga are two-dimensionally arranged.
  • Each pixel Ga includes spectral data (data indicating spectral intensities at a plurality of wavelengths or wavelength bands).
  • control processing device 54 executes an inspection routine.
  • the inspection routine is repeatedly performed every time a spectrum image G in a range corresponding to one PTP sheet 1 is acquired.
  • step S11 the control processing device 54 extracts a pixel corresponding to the tablet 5 from each pixel Ga of the spectrum image G, that is, a pixel (target pixel) Gb to be analyzed.
  • FIG. 15 is an explanatory diagram for explaining the relationship between the conveyance direction imaging range D and the spectrum image G. 13 and 15, pixels extracted as the target pixel Gb are indicated by hatching.
  • the pixel extraction method is not limited to this, and other methods may be adopted.
  • the integrated value of spectrum data may be calculated for each pixel Ga, and the target pixel Gb may be extracted by determining whether or not the value is equal to or greater than a predetermined threshold.
  • step S12 the control processing device 54 performs a grouping process on the target pixel Gb obtained in step S11.
  • all adjacent target pixels Gb are set as one group.
  • a pixel included in a predetermined range centered on a specific pixel may be determined to be in the same group as the specific pixel.
  • the target pixels Gb grouped into one are handled as the target pixels Gb related to the same tablet 5 (see FIGS. 13 and 15). 13 and 15, the grouped target pixels Gb are surrounded by a thick frame.
  • step S13 the control processing device 54 calculates spectrum data related to the tablets 5 corresponding to the group based on the spectrum data of the target pixel Gb grouped in step S12.
  • all the spectrum data of the grouped target pixels Gb are used to obtain an average value, which is calculated as spectrum data (average spectrum data) related to the tablet 5.
  • spectrum data average spectrum data
  • one or more target pixels Gb may be extracted from the grouped target pixels Gb, and the spectrum data of the target pixels Gb may be calculated as the spectrum data related to the tablet 5.
  • control processing device 54 executes an analysis process in step S14.
  • Such processing corresponds to the analysis step in the present embodiment, and the analysis means in the present embodiment is configured by the function of the control processing device 54 that executes such processing.
  • PCA principal component analysis
  • step S15 the control processing device 54 performs a determination process for determining whether the target tablet 5 is a non-defective product (same product type) or a defective product (different product type). More specifically, the principal component score calculated in step S14 is plotted on a PCA diagram. If the plotted data is within a preset good product range, the product is non-defective (same product type). ).
  • step S15 the series of processing in step S15 is performed for all tablets 5 on the PTP sheet 1, and when there is no “bad” tablet 5, the PTP sheet 1 is treated as a non-defective product. Is determined (step S16), and this routine is terminated. On the other hand, if there is at least one tablet 5 that is “defective”, the PTP sheet 1 is determined to be defective (step S17), and this routine is terminated. These inspection results are output to the display device 73 and the PTP packaging machine 10 (including the defective sheet discharge mechanism).
  • the light receiving surface 69 of the image sensor 64 is divided into two, and the outputs from the two divided light receiving regions 69A and 69B are parallel to two different channels CH1 and CH2, respectively. It is configured to do. As a result, it is possible to increase the imaging speed (spectrum data acquisition speed), and it is possible to increase the speed of inspection for mixing different types using spectroscopic analysis.
  • the partition line 69C between the light receiving areas 69A and 69B on the light receiving surface 69 of the image sensor 64 is arranged along the wavelength dispersion direction of the spectral spectrum H S projected on the light receiving surface 69. ing.
  • intensity data of all the wavelength components of the spectral spectrum H S relating to a predetermined position on the tablet 5 can be acquired from the same channel of the image sensor 64.
  • spectrum data relating to a predetermined position on the tablet 5 can be appropriately acquired.
  • the imaging position adjusting mechanism 55 is provided, and on the light receiving surface 69 of the image sensor 64, the partition line 69C between the light receiving regions 69A and 69B and the spectral spectrum H S related to the tablet 5 do not overlap. As described above, the position of the imaging device 53 is adjusted in advance.
  • the average of the tablets 5 is calculated based on the spectrum data at a plurality of positions on one tablet 5 obtained from the same channel. Spectral data can be calculated. As a result, it is possible to suppress a decrease in inspection accuracy.
  • the object is the tablet 5
  • the type, shape, etc. of the object are not particularly limited, and examples thereof include capsules, supplements, foods, and the like. May be. Tablets include solid preparations such as plain tablets and sugar-coated tablets.
  • the material of the container film 3 and the cover film 4 is not limited to the above embodiment, and other materials may be adopted.
  • the container film 3 may be formed of a metal material mainly made of aluminum, such as an aluminum laminate film.
  • the arrangement and the number of pocket portions 2 in the PTP sheet 1 are not limited to the above-described embodiment, and include various arrangements and numbers including, for example, a type having three rows and 12 pocket portions.
  • a PTP sheet can be employed.
  • the inspection apparatus 22 performs the inspection from the container film 3 side of the PTP film 6. It is good also as a structure by which a different kind mixing inspection is performed.
  • a different product mixing inspection by the inspection device 22 may be performed from the container film 3 side of the PTP sheet 1 conveyed by the take-out conveyor 39.
  • FIG. 22 it is good also as a structure by which the different kind mixing test
  • FIG. it is good also as a structure which test
  • FIG. That is, it is good also as a structure provided with the test
  • the configuration of the illumination device 52 and the imaging device 53 is not limited to the above embodiment.
  • a reflection type diffraction grating, a prism, or the like may be adopted as the spectroscopic means.
  • the spectral data is analyzed by principal component analysis (PCA).
  • PCA principal component analysis
  • the present invention is not limited to this, and other known methods such as PLS regression analysis may be used. Good.
  • the inspection device 22 is provided in the PTP packaging machine 10 (inline). Instead, the PTP sheet 1 is taken off-line separately from the PTP packaging machine 10. It is good also as a structure provided with the test
  • the light receiving surface 69 is divided into two in the vertical direction as the image sensor 64 of the camera 63, and the outputs from the two divided light receiving regions 69A and 69B are respectively two different channels CH1 and CH2.
  • An interline transfer type CCD area sensor which is performed in parallel is employed.
  • the configuration of the image sensor 64 is not limited to this.
  • a CCD area sensor such as a full frame transfer method, a frame transfer method, or a frame interline transfer method may be employed.
  • a CCD area sensor such as a full frame transfer method, a frame transfer method, or a frame interline transfer method may be employed.
  • a CMOS area sensor or an MCT (HgCdTe) sensor may be employed.
  • the number of channels and the partition configuration of the light receiving area are not limited to the above embodiment, and other configurations may be adopted.
  • an image sensor (area sensor) in which the light receiving area is divided into three or more areas may be employed.
  • the image pickup device 80 shown in the figure has a configuration in which the light receiving area is divided into four in the film width direction (Y direction), and outputs from the four areas are performed in parallel from four different channels CH1, CH2, CH3, and CH4, respectively. It has become.
  • the image pickup device 80 is configured so that partition lines (boundary portions of the plurality of regions) 80a, 80b, and 80c that divide the light receiving region into a plurality of regions corresponding to the channels CH1 to CH4 are all along the film conveyance direction (X direction). Is provided.
  • the configuration related to the imaging position adjustment mechanism 55 that adjusts the position of the imaging device 53 is not limited to the above-described embodiment, and other configurations may be adopted.
  • the imaging position adjustment mechanism 55 may be omitted.
  • the operator adjusts the position of the imaging device 53 by operating the input device 72 and the like while visually checking the central reference line (line light R) irradiated on the container film 3. It has a configuration.
  • the position adjustment procedure of the imaging device 53 is not limited to this.
  • a configuration may be adopted in which the operator adjusts the position of the imaging device 53 while looking at the display device 73 based on image data captured by the imaging device 53 (or other imaging means provided separately).
  • the center reference line indicating the position corresponding to the partition line 69C that divides the light receiving surface 69 of the image sensor 64 into the first light receiving region 69A and the second light receiving region 69B may be displayed on the display device 73. .
  • the position of the pocket portion 2 or the like is detected based on image data picked up by the image pickup device 53 (or other image pickup means provided separately), or the pre-registered PTP sheet 1, pocket portion 2, tablet 5 or the like.
  • the position of the pocket portion 2 or the like may be specified based on the shape and dimensions of the above, and the imaging position adjustment mechanism 55 may automatically adjust the position of the imaging device 53 according to this.

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Abstract

L'invention concerne un dispositif d'inspection, une machine d'emballage PTP et un procédé de production d'une feuille PTP, au moyen desquels il est possible d'inspecter plus rapidement un mélange de différentes classes de produit à l'aide d'une analyse spectroscopique, et également de limiter toute diminution de la précision d'inspection. Un dispositif d'inspection (22) selon l'invention inspecte le mélange de différentes classes de produit, le dispositif d'inspection étant pourvu : d'un dispositif d'éclairage (52) qui peut projeter une lumière infrarouge proche sur des comprimés (5) qui sont contenus dans des sections de poche (2) d'un film récipient (3) ; d'un dispositif d'imagerie (53) apte à disperser la lumière réfléchie qui est réfléchie par les comprimés (5) et à capturer le spectre spectroscopique de la lumière réfléchie ; et d'un dispositif de traitement de commande destiné à acquérir des données spectrales sur la base du spectre spectroscopique capturé par le dispositif d'imagerie (53) et à réaliser un traitement spectroscopique prédéterminé sur la base des données spectrales. Le dispositif d'imagerie (53) est pourvu d'éléments d'imagerie qui comportent des surfaces de réception de lumière délimitées en une pluralité de régions et qui réalisent une sortie à partir de la pluralité de régions délimitées ayant chacune des canaux différents. Des lignes de démarcation qui délimitent la pluralité de régions sont agencées de façon à suivre une direction de dispersion de longueur d'onde du spectre spectroscopique projeté sur les surfaces de réception de lumière.
PCT/JP2017/037652 2017-04-27 2017-10-18 Dispositif d'inspection, machine d'emballage ptp et procédé de production de feuille ptp WO2018198403A1 (fr)

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JP2017-088314 2017-04-27

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JP2019174328A (ja) * 2018-03-29 2019-10-10 Ckd株式会社 検査装置、ｐｔｐ包装機、及び、検査方法
KR20210118063A (ko) * 2019-01-25 2021-09-29 다카노 가부시키가이샤 화상 검사 장치
JP7215218B2 (ja) * 2019-02-25 2023-01-31 セイコーエプソン株式会社 分光検査方法、画像処理装置、及びロボットシステム

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WO1999029103A1 (fr) * 1997-11-28 1999-06-10 Hamamatsu Photonics K.K. Dispositif de capture d'images a semi-conducteurs et analyseur utilisant ledit dispositif
US5986267A (en) * 1997-11-06 1999-11-16 Princeton Instruments, Inc. Asymmetrically split charged coupled device
JP2010112887A (ja) * 2008-11-07 2010-05-20 Astellas Pharma Inc 主成分分析方法、主成分分析装置、異種品検出装置、主成分分析プログラム、及び、主成分分析プログラムが記録された記録媒体
JP2015087147A (ja) * 2013-10-29 2015-05-07 Ckd株式会社 検査装置及びｐｔｐ包装機

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Publication number Priority date Publication date Assignee Title
US5986267A (en) * 1997-11-06 1999-11-16 Princeton Instruments, Inc. Asymmetrically split charged coupled device
WO1999029103A1 (fr) * 1997-11-28 1999-06-10 Hamamatsu Photonics K.K. Dispositif de capture d'images a semi-conducteurs et analyseur utilisant ledit dispositif
JP2010112887A (ja) * 2008-11-07 2010-05-20 Astellas Pharma Inc 主成分分析方法、主成分分析装置、異種品検出装置、主成分分析プログラム、及び、主成分分析プログラムが記録された記録媒体
JP2015087147A (ja) * 2013-10-29 2015-05-07 Ckd株式会社 検査装置及びｐｔｐ包装機

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