WO2018189020A3 - Omega-3 fatty acid, homocystein and vitamin d levels to identify and attenuate cognitive aging in individuals - Google Patents
Omega-3 fatty acid, homocystein and vitamin d levels to identify and attenuate cognitive aging in individuals Download PDFInfo
- Publication number
- WO2018189020A3 WO2018189020A3 PCT/EP2018/058701 EP2018058701W WO2018189020A3 WO 2018189020 A3 WO2018189020 A3 WO 2018189020A3 EP 2018058701 W EP2018058701 W EP 2018058701W WO 2018189020 A3 WO2018189020 A3 WO 2018189020A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- omega
- vitamin
- levels
- homocystein
- individuals
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR112019020008A BR112019020008A2 (en) | 2017-04-11 | 2018-04-05 | methods to identify predisposition to cognitive decline and agents to mitigate or prevent cognitive decline or improve cognitive ability |
MX2019010828A MX2019010828A (en) | 2017-04-11 | 2018-04-05 | Omega-3 fatty acid, homocystein and vitamin d levels to identify and attenuate cognitive aging in individuals. |
EP18714287.2A EP3609491A2 (en) | 2017-04-11 | 2018-04-05 | Omega-3 fatty acid, homocystein and vitamin d levels to identify and attenuate cognitive aging in individuals |
CA3054864A CA3054864A1 (en) | 2017-04-11 | 2018-04-05 | Methods for identifying pre-disposition to cognitive decline and agents for reducing or preventing cognitive decline, or improving cognitive ability |
AU2018251092A AU2018251092B2 (en) | 2017-04-11 | 2018-04-05 | Omega-3 fatty acid, homocystein and vitamin D levels to identify and attenuate cognitive aging in individuals |
CN201880018724.5A CN110430873A (en) | 2017-04-11 | 2018-04-05 | Omega-3 fatty acid, homocysteine and the vitamin D level of cognition aging are identified and weakened in individual |
US16/603,688 US20210263048A1 (en) | 2017-04-11 | 2018-04-05 | Methods for identifying pre-disposition to cognitive decline and agents for reducing or preventing cognitive decline, or improving cognitive ability |
JP2019551444A JP7270547B2 (en) | 2017-04-11 | 2018-04-05 | Levels of omega-3 fatty acids, homocysteine and vitamin D to identify and reduce cognitive aging in individuals. |
JP2022129345A JP7434459B2 (en) | 2017-04-11 | 2022-08-15 | Levels of omega-3 fatty acids, homocysteine and vitamin D to identify and reduce cognitive aging in individuals |
US18/120,189 US20230226097A1 (en) | 2017-04-11 | 2023-03-10 | Methods for identifying pre-disposition to cognitive decline and agents for reducing or preventing cognitive decline, or improving cognitive ability |
AU2024200882A AU2024200882A1 (en) | 2017-04-11 | 2024-02-12 | Omega-3 fatty acid, homocystein and vitamin D levels to identify and attenuate cognitive aging in individuals |
Applications Claiming Priority (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762484119P | 2017-04-11 | 2017-04-11 | |
US201762484156P | 2017-04-11 | 2017-04-11 | |
US62/484,119 | 2017-04-11 | ||
US62/484,156 | 2017-04-11 | ||
PCT/EP2017/074731 WO2018060396A1 (en) | 2016-09-29 | 2017-09-29 | Omega 3 fatty acids and choline as neuroprotectant in patients with no dementia |
EP17193916.8A EP3388061A1 (en) | 2017-04-11 | 2017-09-29 | Omega 3 fatty acids, no releasing compound, vitamin b12 and choline as neuroprotectant in patients with no dementia |
EP17193916.8 | 2017-09-29 | ||
EPPCT/EP2017/074731 | 2017-09-29 | ||
US201762580574P | 2017-11-02 | 2017-11-02 | |
US62/580,574 | 2017-11-02 | ||
PCT/EP2017/082148 WO2018188771A1 (en) | 2017-04-11 | 2017-12-11 | Omega-3 fatty acid and vitamin d levels to identify and attenuate cognitive aging in individuals |
EPPCT/EP2017/082148 | 2017-12-11 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/603,688 A-371-Of-International US20210263048A1 (en) | 2017-04-11 | 2018-04-05 | Methods for identifying pre-disposition to cognitive decline and agents for reducing or preventing cognitive decline, or improving cognitive ability |
US18/120,189 Division US20230226097A1 (en) | 2017-04-11 | 2023-03-10 | Methods for identifying pre-disposition to cognitive decline and agents for reducing or preventing cognitive decline, or improving cognitive ability |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2018189020A2 WO2018189020A2 (en) | 2018-10-18 |
WO2018189020A3 true WO2018189020A3 (en) | 2019-04-18 |
Family
ID=63792325
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2017/082148 WO2018188771A1 (en) | 2017-04-11 | 2017-12-11 | Omega-3 fatty acid and vitamin d levels to identify and attenuate cognitive aging in individuals |
PCT/EP2018/058710 WO2018189022A1 (en) | 2017-04-11 | 2018-04-05 | Compositions and methods that attenuate cognitive aging in individuals who do not have dementia |
PCT/EP2018/058701 WO2018189020A2 (en) | 2017-04-11 | 2018-04-05 | Methods for identifying pre-disposition to cognitive decline and agents for reducing or preventing cognitive decline, or improving cognitive ability |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2017/082148 WO2018188771A1 (en) | 2017-04-11 | 2017-12-11 | Omega-3 fatty acid and vitamin d levels to identify and attenuate cognitive aging in individuals |
PCT/EP2018/058710 WO2018189022A1 (en) | 2017-04-11 | 2018-04-05 | Compositions and methods that attenuate cognitive aging in individuals who do not have dementia |
Country Status (2)
Country | Link |
---|---|
US (1) | US20230226097A1 (en) |
WO (3) | WO2018188771A1 (en) |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002003074A1 (en) * | 2000-07-04 | 2002-01-10 | Axis-Shield Asa | Diagnostic method for alzheimer's disease based on holo-transcobalamin ii |
US20020182196A1 (en) * | 2001-04-19 | 2002-12-05 | Mccleary Edward Larry | Composition and method for normalizing impaired or deteriorating neurological function |
WO2010143053A1 (en) * | 2009-06-10 | 2010-12-16 | Energy4Life Ag | Methods and compositions for treating insulin resistance, diabetes mellitus type 2, metabolic syndrome and related disorders |
WO2011143587A1 (en) * | 2010-05-13 | 2011-11-17 | Nitromega Corp. | Nitro fatty acids - neuroprotection and/or inhibition of cognitive decline |
WO2014122290A1 (en) * | 2013-02-08 | 2014-08-14 | Centre National De La Recherche Scientifique (Cnrs) | Dyrk1a marker for alzheimer's disease |
US20140271844A1 (en) * | 2013-03-15 | 2014-09-18 | Nitromega Corp. | Compositions containing nitro fatty acids |
US20150086625A1 (en) * | 2008-12-31 | 2015-03-26 | Nitromega Corp. | Nutraceuticals containing nitro fatty acids |
WO2015140545A1 (en) * | 2014-03-20 | 2015-09-24 | Isis Innovation Limited | Combination therapy comprising an omega-3 fatty acid, a folate species and a vitamin b12 species |
WO2016207794A1 (en) * | 2015-06-22 | 2016-12-29 | Nestec Sa | Compositions and methods for enhancing neurogenesis in animals |
WO2017004436A2 (en) * | 2015-07-01 | 2017-01-05 | The Regents Of The University Of California | A therapeutic system comprising pharmaceuticals in combination with metabolic enhancement for neurodegeneration |
-
2017
- 2017-12-11 WO PCT/EP2017/082148 patent/WO2018188771A1/en unknown
-
2018
- 2018-04-05 WO PCT/EP2018/058710 patent/WO2018189022A1/en unknown
- 2018-04-05 WO PCT/EP2018/058701 patent/WO2018189020A2/en unknown
-
2023
- 2023-03-10 US US18/120,189 patent/US20230226097A1/en active Pending
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002003074A1 (en) * | 2000-07-04 | 2002-01-10 | Axis-Shield Asa | Diagnostic method for alzheimer's disease based on holo-transcobalamin ii |
US20020182196A1 (en) * | 2001-04-19 | 2002-12-05 | Mccleary Edward Larry | Composition and method for normalizing impaired or deteriorating neurological function |
US20150086625A1 (en) * | 2008-12-31 | 2015-03-26 | Nitromega Corp. | Nutraceuticals containing nitro fatty acids |
WO2010143053A1 (en) * | 2009-06-10 | 2010-12-16 | Energy4Life Ag | Methods and compositions for treating insulin resistance, diabetes mellitus type 2, metabolic syndrome and related disorders |
WO2011143587A1 (en) * | 2010-05-13 | 2011-11-17 | Nitromega Corp. | Nitro fatty acids - neuroprotection and/or inhibition of cognitive decline |
WO2014122290A1 (en) * | 2013-02-08 | 2014-08-14 | Centre National De La Recherche Scientifique (Cnrs) | Dyrk1a marker for alzheimer's disease |
US20140271844A1 (en) * | 2013-03-15 | 2014-09-18 | Nitromega Corp. | Compositions containing nitro fatty acids |
WO2015140545A1 (en) * | 2014-03-20 | 2015-09-24 | Isis Innovation Limited | Combination therapy comprising an omega-3 fatty acid, a folate species and a vitamin b12 species |
WO2016207794A1 (en) * | 2015-06-22 | 2016-12-29 | Nestec Sa | Compositions and methods for enhancing neurogenesis in animals |
WO2017004436A2 (en) * | 2015-07-01 | 2017-01-05 | The Regents Of The University Of California | A therapeutic system comprising pharmaceuticals in combination with metabolic enhancement for neurodegeneration |
Non-Patent Citations (2)
Title |
---|
BARBERGER-GATEAU P: "Nutrition and brain aging: How can we move ahead?", EUROPEAN JOURNAL OF CLINICAL NUTRITION, NATURE PUBLISHING GROUP, GB, vol. 68, no. 11, 13 November 2014 (2014-11-13), pages 1245 - 1249, XP009503472, ISSN: 0954-3007, DOI: 10.1038/EJCN.2014.177 * |
BOWMAN GENE ET AL: "Nutrient biomarker patterns and cognitive decline in older adults", THE FASEB JOURNAL, FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, US, vol. 28, no. 1, Suppl. S, 31 March 2014 (2014-03-31), pages 124.6, XP009503473, ISSN: 0892-6638 * |
Also Published As
Publication number | Publication date |
---|---|
WO2018188771A1 (en) | 2018-10-18 |
WO2018189020A2 (en) | 2018-10-18 |
US20230226097A1 (en) | 2023-07-20 |
WO2018189022A1 (en) | 2018-10-18 |
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