WO2018187268A1 - Hermetically-sealed package - Google Patents
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- WO2018187268A1 WO2018187268A1 PCT/US2018/025801 US2018025801W WO2018187268A1 WO 2018187268 A1 WO2018187268 A1 WO 2018187268A1 US 2018025801 W US2018025801 W US 2018025801W WO 2018187268 A1 WO2018187268 A1 WO 2018187268A1
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- A61N1/37—Monitoring; Protecting
- A61N1/3702—Physiological parameters
- A61N1/3704—Circuits specially adapted therefor, e.g. for sensitivity control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/38—Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
- A61N1/39—Heart defibrillators
- A61N1/3956—Implantable devices for applying electric shocks to the heart, e.g. for cardioversion
Definitions
- sealed packages described herein can be utilized for remote patient diagnostics, monitoring, and treatment with any suitable system.
- one or more embodiments of sealed packages described herein can include an implantable medical device or system disposed within the sealed package.
- the sealed package can be electrically connected to an implantable medical device.
- any implantable medical device or system employing leads may be used in conjunction with the various embodiments of sealed packages described herein.
- the electronic devices 40 can be electrically connected to device contacts 44 and conductors 46, 82, 92 using any suitable technique or techniques.
- solder bumps and/or contact pads of the electronic devices 40 can be directly attached to one or more contacts 44 using any suitable technique or combination of techniques, e.g., soldering, welding, laser bonding, mechanically connecting (e.g., direct-pressure contacts), etc.
- the method 800 includes disposing a hermetically sealed package within a body of the patient at 802. Any suitable hermetically sealed package can be utilized with method 800, e.g., sealed package 10 of FIGS. 1-5. Although method 800 is described regarding the package 10 of FIGS. 1-5, the method can be utilized with any suitable sealed package.
- light from the light source 80 can be directed such that it is incident upon one or both of tissue or an arter -, other desired physiological location of the patient. Any suitable wavelength or wavelengths of light can be emitted by the light source 80 and directed to a desired location.
- a portion of the light emitted by the light source 80 and scattered by one or both of tissue and the artery of the patient can be detected utilizing the detector 90.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Diabetes (AREA)
- General Engineering & Computer Science (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Cardiology (AREA)
- Physiology (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18721202.2A EP3606606B1 (en) | 2017-04-03 | 2018-04-03 | Hermetically-sealed package |
CN201880022267.7A CN110461413B (zh) | 2017-04-03 | 2018-04-03 | 气密密封封装 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/477,835 US10542921B2 (en) | 2017-04-03 | 2017-04-03 | Hermetically-sealed package and method of forming same |
US15/477,835 | 2017-04-03 |
Publications (1)
Publication Number | Publication Date |
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WO2018187268A1 true WO2018187268A1 (en) | 2018-10-11 |
Family
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Family Applications (1)
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---|---|---|---|
PCT/US2018/025801 WO2018187268A1 (en) | 2017-04-03 | 2018-04-03 | Hermetically-sealed package |
Country Status (4)
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US (1) | US10542921B2 (zh) |
EP (1) | EP3606606B1 (zh) |
CN (1) | CN110461413B (zh) |
WO (1) | WO2018187268A1 (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1762259T3 (da) | 2005-09-12 | 2011-01-03 | Unomedical As | Indføringsindretning til infusionssæt med en første og en anden fjederenhed |
WO2012123274A1 (en) | 2011-03-14 | 2012-09-20 | Unomedical A/S | Inserter system with transport protection |
US10463285B2 (en) | 2017-04-03 | 2019-11-05 | Medtronic, Inc. | Hermetically-sealed package and method of forming same |
CN108926340B (zh) * | 2017-05-23 | 2023-04-28 | 松下知识产权经营株式会社 | 计测装置 |
US10888009B2 (en) * | 2018-10-26 | 2021-01-05 | Medtronic, Inc. | Method of forming a sealed package |
US10950511B2 (en) * | 2018-10-30 | 2021-03-16 | Medtronic, Inc. | Die carrier package and method of forming same |
EP3673797B1 (en) * | 2018-12-27 | 2024-06-05 | Polar Electro Oy | Wearable heart activity sensor device |
US11857299B2 (en) | 2018-12-27 | 2024-01-02 | Polar Electro Oy | Wearable heart activity sensor device |
CA3141608A1 (en) | 2019-05-20 | 2020-11-26 | Unomedical A/S | Rotatable infusion device and methods thereof |
US11234620B2 (en) | 2019-06-24 | 2022-02-01 | Medtronic, Inc. | Performing measurements using sensors of a medical device system |
US11865639B2 (en) * | 2019-12-13 | 2024-01-09 | Medtronic, Inc. | Hermetic assembly and device including same |
WO2023203415A1 (en) * | 2022-04-22 | 2023-10-26 | Medtronic, Inc. | Determination of cardiac flow rate with an implantable medical device |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7013178B2 (en) | 2002-09-25 | 2006-03-14 | Medtronic, Inc. | Implantable medical device communication system |
US20090156918A1 (en) * | 2007-12-12 | 2009-06-18 | Davis Timothy J | Implantable optical sensor and method for use |
US20090156912A1 (en) * | 2007-12-12 | 2009-06-18 | Kuhn Jonathan L | Implantable optical sensor and method for manufacture |
US7653434B1 (en) * | 2004-08-05 | 2010-01-26 | Pacesetter, Inc. | Autonomous sensor modules for patient monitoring |
US20100262208A1 (en) * | 2009-04-08 | 2010-10-14 | National Ict Australia Limited | Electronics package for an active implantable medical device |
US20100317947A1 (en) * | 2009-06-10 | 2010-12-16 | Can Cinbis | Tissue Oxygenation Monitoring in Heart Failure |
US20160185081A1 (en) | 2014-12-24 | 2016-06-30 | Medtronic, Inc. | Kinetically limited nano-scale diffusion bond structures and methods |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6125290A (en) | 1998-10-30 | 2000-09-26 | Medtronic, Inc. | Tissue overgrowth detector for implantable medical device |
US6125291A (en) | 1998-10-30 | 2000-09-26 | Medtronic, Inc. | Light barrier for medical electrical lead oxygen sensor |
US5902326A (en) | 1997-09-03 | 1999-05-11 | Medtronic, Inc. | Optical window for implantable medical devices |
US6134459A (en) | 1998-10-30 | 2000-10-17 | Medtronic, Inc. | Light focusing apparatus for medical electrical lead oxygen sensor |
US6780661B1 (en) | 2000-04-12 | 2004-08-24 | Finisar Corporation | Integration of top-emitting and top-illuminated optoelectronic devices with micro-optic and electronic integrated circuits |
US6583445B1 (en) | 2000-06-16 | 2003-06-24 | Peregrine Semiconductor Corporation | Integrated electronic-optoelectronic devices and method of making the same |
US20070156085A1 (en) | 2005-12-30 | 2007-07-05 | Schulhauser Randal C | Implantable perfusion sensor |
US8145288B2 (en) | 2006-08-22 | 2012-03-27 | Nellcor Puritan Bennett Llc | Medical sensor for reducing signal artifacts and technique for using the same |
DE602008004225D1 (zh) | 2007-02-28 | 2011-02-10 | Medtronic Inc | |
US8170636B2 (en) | 2007-06-05 | 2012-05-01 | Medtronic, Inc. | Optical sensor confidence algorithm |
JP5094252B2 (ja) * | 2007-07-11 | 2012-12-12 | キヤノン株式会社 | 撮像装置及びその制御方法 |
US7805174B2 (en) | 2007-09-18 | 2010-09-28 | Cardiac Pacemakers, Inc. | Implantable electro-optical sensor |
US8216134B2 (en) | 2007-12-12 | 2012-07-10 | Medtronic, Inc. | Implantable optical sensor and method for manufacture |
US8452402B2 (en) | 2008-04-23 | 2013-05-28 | Medtronic, Inc. | Optical sensing device for use in a medical device |
US9326711B2 (en) | 2008-06-30 | 2016-05-03 | Medtronic, Inc. | Optical perfusion sensor detector |
US20100022856A1 (en) | 2008-07-28 | 2010-01-28 | Medtronic, Inc. | Implantable optical hemodynamic sensor including light transmission member |
US10080499B2 (en) | 2008-07-30 | 2018-09-25 | Medtronic, Inc. | Implantable medical system including multiple sensing modules |
US8332037B2 (en) | 2008-11-05 | 2012-12-11 | Incube Labs, Llc | Housing structure for a medical implant including a monolithic substrate |
WO2010085526A1 (en) | 2009-01-22 | 2010-07-29 | Medtronic, Inc. | Co-location of emitters and detectors and method of operation |
US9126049B2 (en) | 2009-06-10 | 2015-09-08 | Medtronic, Inc. | Shock reduction using absolute calibrated tissue oxygen saturation and total hemoglobin volume fraction |
EP2440116B1 (en) | 2009-06-10 | 2018-02-28 | Medtronic, Inc. | Device and method for monitoring of absolute oxygen saturation and tissue hemoglobin concentration |
WO2010144662A1 (en) | 2009-06-10 | 2010-12-16 | Medtronic, Inc. | Absolute calibrated tissue oxygen saturation and total hemoglobin volume fraction |
US8352008B2 (en) * | 2009-06-10 | 2013-01-08 | Medtronic, Inc. | Active noise cancellation in an optical sensor signal |
US20110066017A1 (en) | 2009-09-11 | 2011-03-17 | Medtronic, Inc. | Method and apparatus for post-shock evaluation using tissue oxygenation measurements |
US8458543B2 (en) | 2010-01-07 | 2013-06-04 | Freescale Semiconductor, Inc. | Scan based test architecture and method |
WO2011093913A1 (en) | 2010-01-29 | 2011-08-04 | Medtronic, Inc. | Optical sensor for medical device |
US8795595B2 (en) | 2010-04-07 | 2014-08-05 | Medtronic Minimed, Inc. | Sensor substrate systems and methods |
US8489164B2 (en) | 2010-10-27 | 2013-07-16 | Medtronic, Inc. | Monitoring of tissue hemoglobin concentration |
US8548543B2 (en) * | 2010-10-29 | 2013-10-01 | Medtronic, Inc. | Symmetrically packaged optical sensors for implantable medical devices |
US8489168B2 (en) | 2010-11-18 | 2013-07-16 | Medtronic, Inc. | Coefficent determination for blood oxygen saturation and total hemoglobin concentration indices |
EP3906842A1 (en) * | 2011-07-26 | 2021-11-10 | Glysens Incorporated | Tissue implantable sensor with hermetically sealed housing |
US8664756B2 (en) | 2012-07-24 | 2014-03-04 | Medtronic, Inc. | Reconstituted wafer package with high voltage discrete active dice and integrated field plate for high temperature leakage current stability |
US8781547B2 (en) | 2011-10-28 | 2014-07-15 | Medtronic, Inc. | Method and apparatus for calibrating an absolute oxygen saturation sensor |
US8824161B2 (en) | 2012-06-15 | 2014-09-02 | Medtronic, Inc. | Integrated circuit packaging for implantable medical devices |
US11213690B2 (en) | 2012-06-15 | 2022-01-04 | Medtronic, Inc. | Wafer level packages of high voltage units for implantable medical devices |
US9220911B2 (en) * | 2013-09-11 | 2015-12-29 | Medtronic, Inc. | Implantable medical devices with power supply noise isolation |
US9999774B2 (en) | 2014-05-06 | 2018-06-19 | Medtronic, Inc. | Optical trigger for therapy delivery |
US9669224B2 (en) | 2014-05-06 | 2017-06-06 | Medtronic, Inc. | Triggered pacing system |
US10292630B2 (en) * | 2015-06-01 | 2019-05-21 | Verily Life Sciences Llc | Optical sensor for bandage type monitoring device |
US10463285B2 (en) | 2017-04-03 | 2019-11-05 | Medtronic, Inc. | Hermetically-sealed package and method of forming same |
-
2017
- 2017-04-03 US US15/477,835 patent/US10542921B2/en active Active
-
2018
- 2018-04-03 WO PCT/US2018/025801 patent/WO2018187268A1/en unknown
- 2018-04-03 EP EP18721202.2A patent/EP3606606B1/en active Active
- 2018-04-03 CN CN201880022267.7A patent/CN110461413B/zh active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7013178B2 (en) | 2002-09-25 | 2006-03-14 | Medtronic, Inc. | Implantable medical device communication system |
US7653434B1 (en) * | 2004-08-05 | 2010-01-26 | Pacesetter, Inc. | Autonomous sensor modules for patient monitoring |
US20090156918A1 (en) * | 2007-12-12 | 2009-06-18 | Davis Timothy J | Implantable optical sensor and method for use |
US20090156912A1 (en) * | 2007-12-12 | 2009-06-18 | Kuhn Jonathan L | Implantable optical sensor and method for manufacture |
US20100262208A1 (en) * | 2009-04-08 | 2010-10-14 | National Ict Australia Limited | Electronics package for an active implantable medical device |
US20100317947A1 (en) * | 2009-06-10 | 2010-12-16 | Can Cinbis | Tissue Oxygenation Monitoring in Heart Failure |
US20160185081A1 (en) | 2014-12-24 | 2016-06-30 | Medtronic, Inc. | Kinetically limited nano-scale diffusion bond structures and methods |
Also Published As
Publication number | Publication date |
---|---|
CN110461413B (zh) | 2023-10-20 |
EP3606606A1 (en) | 2020-02-12 |
US20180279924A1 (en) | 2018-10-04 |
CN110461413A (zh) | 2019-11-15 |
US10542921B2 (en) | 2020-01-28 |
EP3606606B1 (en) | 2023-10-18 |
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