Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
  • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
  • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
  • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2002/823—Stents, different from stent-grafts, adapted to cover an aneurysm
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
  • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
  • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
  • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
  • A61F2002/9155—Adjacent bands being connected to each other
  • A61F2002/91575—Adjacent bands being connected to each other connected peak to trough
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
  • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
  • A61F2230/0028—Shapes in the form of latin or greek characters
  • A61F2230/0054—V-shaped

Definitions

• the present invention relates to an expandable tube for deployment within a blood vessel, particularly for use in redirecting blood flow away from an aneurismal sac.
• An intracranial aneurysm is a weak region in the wall of an artery in the brain, where dilation or ballooning of the arterial wall may occur. Histologically, decreases in the tunica media, the middle muscular layer of the artery, and the internal elastic lamina cause structural defects. These defects, combined with hemodynamic factors, lead to aneurismal out-pouchings. Intracranial aneurysms are quite common diseases with a prevalence ranging from one to five percent among adult population according to autopsy studies. In the US alone, ten to twelve million people may have intracranial aneurysms.
• Endovascular coiling is a less invasive method involving placement of one or more coils, delivered through a catheter, into the aneurysm until the sac of the aneurysm is completely packed with coils. It helps to trigger a thrombus inside the aneurysm. Although endovascular coiling is deemed to be safer than surgical clipping, it has its own limitations.
• This problem may be mitigated by using a stent in combination with coiling embolization, but the procedure is difficult and time-consuming.
• an expandable tube sometimes referred to as a stent
• a tube with an area of relatively low porosity is placed across the aneurysm neck in such a way as to redirect blood flow away from the sac and trigger formation of a thrombus within the aneurysm.
• the aneurysm solidifies naturally on itself, there is less danger of its rupture.
• the aneurysm will gradually shrink as the thrombus is absorbed. Consequently, the pressure applied on the surrounding tissue can be removed. It is difficult, however, to manufacture a tube having optimal characteristics for this application.
• the tube has to be flexible enough to pass through and adapt to the shape of the very tortuous blood vessels in the brain while at the same time providing sufficient coverage (low porosity) to redirect blood flow away from the aneurysm to an adequate extent.
• an expandable tube for deployment within a blood vessel comprising: an elongate frame that is reversibly switchable from a radially expanded and longitudinally contracted state to a radially contracted and longitudinally expanded state, wherein: the frame comprises a plurality of longitudinally deformable elements for providing longitudinal expansion and contraction of the frame and a plurality of circumferentially deformable elements for providing radial expansion and contraction of the frame; the longitudinally deformable elements can be expanded or contracted longitudinally substantially without any change in the shape of the circumferentially deformable elements; the plurality of circumferentially deformable elements comprises a plurality of sets of
• each set of circumferentially deformable elements forming a closed ring around an axis of elongation of the frame, each closed ring consisting exclusively of the
• circumferentially deformable elements and at least two of the closed rings occupy overlapping ranges of longitudinal positions when the frame is in the radially expanded and longitudinally contracted state and occupy non-overlapping ranges of longitudinal positions when the frame is in the radially contracted and longitudinally expanded state.
• the presently disclosed tube can be configured to redirect blood flow away from an aneurismal sac in a minimally invasive method that is much safer, has lower morbitity and mortality rates, requires less hospital stay and reduces the overall treatment cost.
• the presently disclosed tube does not involve coils, which leads to several advantages, e.g. the mass effect of the aneurysm is reduced, and the tube is suitable for treating both saccular and fusiform aneurysms.
• the presently disclosed tube can provide higher radial strength, more controlled deployment and tailored surface coverage which is useful to prevent the blockage of branch blood vessels.
• a frame that elongates as part of the radial contraction allows a high degree of radial contraction even when the frame is configured to present a low porosity in the radially expanded state. It is therefore possible to provide a frame that can be inserted into delivery catheters of very small diameter, for example less than 3mm diameter, or more preferably less than 1mm diameter. This property expands the range of clinical uses that are available.
• the closed rings form an alternating sequence of first type closed rings and second type closed rings, wherein: each of one or more of the circumferentially deformable elements on each first type closed ring is aligned in a direction parallel to the axis of elongation of the elongate frame with a corresponding identical one of the circumferentially deformable elements on each other first type closed ring and is not aligned with a corresponding identical one of the circumferentially deformable elements on any of the second type closed rings, when the frame is in the radially expanded and longitudinally contracted state.
• twisting is further prevented by arranging for the longitudinally deformable elements to comprise sets of identical first type longitudinally deformable elements and sets of identical second type longitudinally deformable elements, wherein the sets of first type longitudinally deformable elements and the sets of second type longitudinally deformable elements are arranged in an alternating sequence such that each first type closed ring is connected to the next second type closed ring in a given direction parallel to the axis of elongation exclusively by first type longitudinally deformable elements and each second type closed ring is connected to the next first type closed ring in the same given direction parallel to the axis of elongation exclusively by second type longitudinally deformable elements, wherein the first type longitudinally deformable elements have a different shape and/or orientation from the second type longitudinally deformable elements, for example mirror images of each other when the frame is viewed in an unfolded plan
• each of one or more of the longitudinally deformable elements is curved along at least 20% of the length of the longitudinally deformable element. This helps to spread the strain over the longitudinally deformable element during the switching from the radially expanded and longitudinally contracted state to the radially contracted and longitudinally expanded state, allowing large overall deformations to be achieved without excessively stressing the longitudinally deformable elements.
• each of one or more of the longitudinally deformable elements is connected to one of the closed rings at a junction and configured such that an angle between the longitudinally deformable element and a circumferentially deformable element at the junction changes by less than 30 degrees during switching from the radially expanded and longitudinally contracted state to the radially contracted and longitudinally expanded state. This feature reduces undesirable stresses at the junction.
• Figure 1 is a schematic perspective view of the outer geometry of a tube in a radially expanded and longitudinally contracted state
• Figure 2 is a schematic perspective view of the outer geometry of the tube of Figure 1 in a radially contracted and longitudinally expanded state;
• Figure 3 is an unfolded view of an example frame in the radially expanded and longitudinally contracted state;
• Figure 4 depicts a portion of the frame of Figure 3 illustrating closed rings of circumferentially deformable elements having overlapping ranges of longitudinal positions;
• Figure 5 schematically depicts expansion of longitudinally deformable elements substantially without any change in shape of circumferentially deformable elements in an unfolded view of a portion of a frame
• Figure 6 schematically depicts radial contraction of the frame of Figure 5;
• Figure 7 depicts a portion of the frame of Figure 3 illustrating an alternating sequence of first type and second type rings
• Figure 8 depicts a portion of the frame of Figure 7 magnified to show a junction between a circumferentially deformable element and a longitudinally deformable element.
• Embodiments of the invention provide a tube suitable for deployment within a blood vessel.
• the tube comprises an elongate frame 2.
• Figure 1 depicts the outer geometry of the frame 2 in a radially expanded and longitudinally contracted state.
• Figure 2 depicts the outer geometry of the frame 2 in a radially contracted and longitudinally expanded state.
• the frame 2 can be switched reversibly from the radially expanded and longitudinally contracted state shown in Figure 1 to the radially contracted and longitudinally expanded state shown in Figure 2.
• the frame 2 is expandable, optionally self-expanding.
• the frame 2 may comprise a shape memory alloy for example, such as nitinol.
• the frame 2 may comprise a stainless steel, polymer or other biocompatible material.
• the frame 2 is elongate relative to an axis of elongation 4.
• the frame 2 may be cylindrical for example.
• the maximum lateral dimension is the same at all positions and angles (i.e. it is equal to the diameter).
• the maximum lateral dimension may be different at different positions and/or angles.
• the maximum lateral dimension defines the minimum interior diameter of a cylindrical tube (e.g. a delivery catheter) that the frame could be inserted into.
• the frame 2 In the radially contracted state the frame 2 is substantially narrower than in the radially expanded state.
• the maximum lateral dimension is 30% smaller in the radially contracted state, more preferably 50% smaller.
• Radially contracting the frame 2 allows the frame 2 to be inserted into a narrower delivery catheter for deployment at the site of interest. It is generally desirable for the delivery catheter to be as narrow as possible. This is particularly the case where access to a deployment site requires navigation of tortuous regions of vasculature. This may often be the case, for example, when treating a cerebral aneurysm.
• porosity refers to the ratio of the surface area of open regions to the total external surface area occupied by the frame or portion of frame that is being described.
• the total external surface area is the sum of the surface area of the open regions and the surface area of the regions occupied by the material of the frame.
• the total external surface area is simply 2n.R.L, where R is the radius of the cylinder and L is the length of the cylinder.
• Li is the length of the frame in the radially contracted state. This relationship assumes that elements of the frame are not allowed to overlap with each other in the radial direction.
• the frame 2 is configured so that it can be elongated by at least 25%, more preferably by at least 50%, even more preferably by 100% or 150%.
• the elongation can be even longer, for example, 400%, 600%, 800%, or more.
• Figure 3 shows an example frame 2 notionally unfolded so that it is flat (rather than cylindrical).
• the longitudinal axis runs horizontally in the plane of the page and the circumferential direction runs vertically in the plane of the page.
• the longitudinal length of the frame 2 is marked Lo and the
• Figure 4 is a magnified view of a portion of the frame 2 of Figure 3.
• the frame 2 comprises a network of interconnecting arms.
• the interconnecting arms form a plurality of circumferentially deformable elements 6 for providing radial expansion and contraction of the frame 2.
• the frame 2 further comprises a plurality of longitudinally deformable elements 8, distinct from the circumferentially deformable elements 6, for providing longitudinal expansion and contraction of the frame 2.
• the circumferentially deformable elements 6 and the longitudinally deformable elements 8 may be connected together to form an integrally interconnected network, such that there are no material interfaces between any of the elements.
• the frame 2 may be formed for example by laser cutting a hollow tube, by 3D printing, or by other techniques known in the art for manufacturing such structures. All of the circumferentially deformable elements 6 and longitudinally deformable elements 8 may be provided at the same radius and, without any overlaps in the radial direction.
• the plurality of circumferentially deformable elements 6 comprises a plurality of sets of
• each set of circumferentially deformable elements 6 forms a closed ring around the axis of elongation 4 of the frame 2.
• Each closed ring consists exclusively of the circumferentially deformable elements 6.
• each circumferentially deformable element 6 is substantially V-shaped.
• Each closed ring thus consists of a plurality of Vs connected together at the outer ends of the arms of each V.
• Each of the closed rings occupies a range of longitudinal positions.
• three such ranges of positions are marked 11-13 for three different closed rings. It can be seen that the three ranges of longitudinal positions overlap with each other.
• Arranging for the closed rings to overlap in the radially expanded and longitudinally contracted state allows the frame to achieve a low porosity in this state.
• the low porosity may be suitable for example for redirecting blood flow away from an aneurismal sac and thereby promoting thrombus formation in the aneurismal sac.
• the porosity is less than 90%, optionally less than 80%, optionally less than 70%, optionally less than 60%, optionally less than 50%.
• Arranging for the closed rings to overlap in the radially expanded and longitudinally contracted state also helps to provide high radial stiffness by providing a high density of the circumferentially deformable elements per unit length. This may be useful when the tube is used to treat aneurysms and in other applications.
• the frame 2 is further configured such that the closed rings that occupy overlapping longitudinal positions when the frame 2 is in the radially expanded and longitudinally contracted state occupy non- overlapping ranges of longitudinal positions when the frame 2 is in the radially contracted and longitudinally expanded state.
• the closed rings effectively move out of the way of each other and allow the frame to contract radially to a greater extent. This process is illustrated schematically in Figures 5 and 6.
• Figure 5 depicts a portion of a frame 2 of the type depicted in Figure 4 after longitudinal expansion of the frame 2.
• the longitudinal expansion can be achieved, at least partially, by longitudinal expansion of the longitudinal deformable elements 8A and 8B substantially without any change in the shape of the circumferential deformable elements 6 (forming closed rings 21 and 22).
• the longitudinal expansion results in the closed rings no longer overlapping with each other.
• the ranges of longitudinal positions 11-13 no longer overlap.
• Figure 6 depicts the portion of the frame 2 of Figure 5 after a subsequent radial contraction.
• the radial contraction is achieved principally or substantially entirely by deformation of the circumferentially deformable elements.
• the deformation of the circumferentially deformable elements 6 occurs substantially without any deformation of the longitudinally deformable elements for at least a portion of the deformation.
• Figure 5 and the radial contraction of Figure 6 may be achieved in separate stages as depicted in Figures 5 and 6 or may be implemented at the same time or during overlapping time periods.
• each of one or more of the circumferentially deformable elements 6 on one of the closed rings is aligned in a direction parallel to the axis of elongation of the frame 2 with a corresponding identical one of the circumferentially deformable elements 6 on another of the closed rings when the frame 2 is in the radially expanded and longitudinally contracted state.
• the aligned circumferentially deformable elements 6 will also have the same orientation as each other.
• the aligned circumferentially deformable elements 6 will comprise V-shaped elements pointing in the same direction.
• directly adjacent closed rings will comprise circumferentially deformable elements 6 that are aligned with each other.
• this configuration can lead to undesirable twisting of the frame 2 during switching from the radially expanded and longitudinally contracted state to the radially contracted and longitudinally expanded state. Twisting can be reduced by arranging for the aligned circumferentially deformable elements 6 to be separated from each other by at least one closed ring having circumferentially deformable elements 6 that are not aligned.
• the closed rings form an alternating sequence of first type closed rings 21 and second type closed rings 22.
• the first type closed rings 21 and second type closed rings 22 are labelled in Figures 5-7.
• example circumferentially deformable elements 6 have been overlaid with thick lines to indicate the different types of closed ring.
• Thick broken lines indicate example circumferentially deformable elements 6 in first type closed rings 21.
• Thick solid lines indicate example circumferentially deformable elements 6 in second type closed rings 22.
• each of one or more of the circumferentially deformable elements 6 (e.g. V-shaped elements) on each first type closed ring 21 is aligned in a direction parallel to the axis of elongation of the frame 2 with a corresponding identical one of the circumferentially deformable elements 6 on each other first type closed ring 21 and is not aligned with a corresponding identical one of the circumferentially deformable elements on any of the second type closed rings, when the frame is in the radially expanded and longitudinally contracted state.
• each of one or more of the circumferentially deformable elements 6 e.g.
• V-shaped elements) on each second type closed ring 22 is aligned in a direction parallel to the axis of elongation of the frame 2 with a corresponding identical one of the circumferentially deformable elements on each other second type closed ring 22 and is not aligned with a corresponding identical one of the circumferentially deformable elements on any of the first type closed rings 21, when the frame is in the radially expanded and longitudinally contracted state.
• the first type closed rings 21 and the second type closed rings 22 are offset from each other circumferentially when the frame 2 is in the radially expanded and longitudinally contracted state by distance 30.
• the longitudinally deformable elements comprise sets of first type longitudinally deformable elements 8A and sets of identical second type longitudinally deformable elements 8B.
• the sets of first type longitudinally deformable elements 8A and the sets of second type longitudinally deformable elements 8B are arranged in an alternating sequence such that each first type closed ring 21 is connected to the next second type closed ring 22 in a given direction parallel to the axis of elongation exclusively by first type longitudinally deformable elements 8A and each second type closed ring 22 is connected to the next first type closed ring 21 in the same given direction parallel to the axis of elongation exclusively by second type longitudinally deformable elements 8B.
• the first type longitudinally deformable elements 8A have a different shape and/or orientation from the second type longitudinally deformable elements 8B.
• the first type longitudinally deformable elements 8 A are mirror images of the second type longitudinally deformable elements 8B when the frame 2 is viewed in an unfolded planar state (as in Figures 3-8).
• the first type longitudinally deformable elements 8A curve downwards to the right and the second type longitudinally deformable elements are mirror images and curve upwards to the right.
• the embodiment of Figures 3-8 being an example, at least two of the (optionally overlapping) closed rings are identical to each other.
• the identical closed rings may be aligned with each other in the longitudinal direction or may be offset with respect to each other in the circumferential direction, at least in the radially expanded and longitudinally contracted state.
• the embodiment of Figures 3- 8 comprises closed rings of both types: first type closed rings 21 are aligned with first type closed rings 21, second type closed rings 22 are aligned with second type closed rings 22, and first type closed rings 21 are circumferentially offset relative to second type closed rings 22.
• the embodiment of Figures 3-8 being an example, at least two of the (optionally overlapping) closed rings each consists of a plurality of identical circumferentially deformable elements connected together in the same orientation.
• each of the identical circumferentially deformable elements comprises a V-shaped element.
• the closed rings may be formed from plural straight elements, such that at least 50%, optionally at least 75%, optionally at least 85%, optionally at least 90%, optionally at least 95%, of a path along each of the at least two closed rings is formed from elements that are substantially straight. Forming the closed rings in this way helps to provide high radial stiffness.
• two of the closed rings 21,22 are connected to each other exclusively by a plurality of longitudinally deformable elements 8,8A,8B that can be expanded or contracted longitudinally substantially without any change in the shape of the circumferentially deformable elements forming the two closed rings 21,22.
• none of the longitudinally deformable elements 8,8A,8B is connected directly to any other longitudinally deformable element.
• each of one or more of the longitudinally deformable elements 8,8A,8B is curved along at least 20%, optionally along at least 50%, optionally along at least 75%, optionally along at least 90%, optionally along substantially all of, the length of the longitudinally deformable element 8,8A,8B.
• each of one or more of the longitudinally deformable elements 8,8A,8B is connected to one of the closed rings 21,22 at a junction 32 (depicted in Figure 8) and configured such that an angle 34 between the longitudinally deformable element 8,8A,8B and a circumferentially deformable element 6 at the junction 32 changes by less than 30 degrees, optionally less than 20 degrees, optionally less than 10 degrees, during switching from the radially expanded and longitudinally contracted state to the radially contracted and longitudinally expanded state.
• each circumferentially deformable element 6 is substantially V- shaped.
• Each closed ring thus consists of a plurality of Vs connected together at the outer ends of the arms of each V. More generally, the closed rings may be formed from plural straight elements.
• the junctions at which the longitudinally deformable elements are connected to the closed rings of circumferentially deformable elements may be located at a point other than at the centre of a joining region where the two arms of the V join (i.e. away from all such joining regions), and at a point other than at a centre of a joining region where each straight element is joined to a neighbouring straight element (i.e. away from all such joining regions).
• the junction may be located away from the centre of the nearest joining region by 2% or more, optionally 5% or more, optionally 10% or more, optionally 20% or more, optionally 40% or more, of the length of at least one of the arms of the V (e.g. the length of a straight element of the V).
• Locating the junction away from the centre of the joining region reduces the amount of material around the junction, increasing the flexibility of the longitudinally deformable elements near the junction and allowing for greater longitudinal contraction and expansion of the tube. Locating the junction away from the centre of the joining region also makes it possible to lengthen the longitudinally deformable element, thereby spreading out (and thereby reducing) the bending stresses associated with deformation of the longitudinally deformable element more.
• the two junctions at the respective ends of each of one or more of the longitudinal deformable elements are arranged to be on the outermost sides of the centres of the respective nearest joining regions between arms of the circumferentially deformable elements.
• a first end of a longitudinal deformable element may be connected above the centre of a joining region (as is the case for the leftmost junction 32 in Figure 8) and a second end of the longitudinal deformable element may be connected below the centre of the joining region (as is the case for the rightmost junction 32 in Figure 8, although the particular junction shown belongs to a different longitudinal deformable element of course).
• a joining point i.e. a point at the outer ends of the arms of each V where two adjacent V-shaped elements on the same closed ring join
• a separation distance This separation distance will increase as the tube moves from the radially contracted and longitudinally expanded state to the radially expanded and longitudinally contracted state, as seen by comparing Figures 5 and 6.
• the separation distance in the radially expanded and longitudinally contracted state may be sufficiently large that one of the longitudinally deformable elements 8 and/or a V-shaped element from an adjacent closed ring of circumferentially deformable elements 6 can fit into the space between the two adjacent joining points, as seen in Figures 4 and 8.
• the separation distance in the radially expanded and longitudinally contracted state is such as to allow a vertex of a V-shaped element in an adjacent closed ring located at a circumferential position lying between the circumferential positions of the two joining points (but at a different longitudinal position), and at least a portion of a longitudinally deformable element connected closest to the vertex, to move, during a transition from the frame being in the radially contracted and longitudinally expanded state to the frame being in the radially expanded and longitudinally contracted state, through a notional line joining the two joining points (i.e. so at to move from a longitudinally non- overlapping state to a longitudinally overlapping state).
• the smallest angle between the two arms of the V-shaped elements in the radially expanded and longitudinally contracted state may be larger than 60 degrees, optionally larger than 80 degrees, optionally larger than 100 degrees, optionally larger than 120 degrees.
• Having a sufficiently large separation distance allows adjacent rings of circumferentially-deformable elements to move closer together in the radially expanded and longitudinally contracted state, which in turn decreases the porosity of the tube in this state and improves the performance and effectiveness of the device.
• Providing a relatively large separation distance makes it possible for the longitudinally deformable element to be relatively long, which advantageously spreads out stress along the longitudinally deformable element.
• the tube of any of the above embodiments may be used in a method of treating an aneurysm, comprising deploying the tube over an opening to the aneurismal sac and thereby redirecting blood flow away from the aneurismal sac to promote thrombus formation in the aneurismal sac.

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• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
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• Oral & Maxillofacial Surgery (AREA)
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• Physics & Mathematics (AREA)
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• General Health & Medical Sciences (AREA)
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• Media Introduction/Drainage Providing Device (AREA)
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• 2017
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• 2018
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