WO2018148614A1 - Compositions contenant une capsule souple avec un principe actif - Google Patents

Compositions contenant une capsule souple avec un principe actif Download PDF

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Publication number
WO2018148614A1
WO2018148614A1 PCT/US2018/017722 US2018017722W WO2018148614A1 WO 2018148614 A1 WO2018148614 A1 WO 2018148614A1 US 2018017722 W US2018017722 W US 2018017722W WO 2018148614 A1 WO2018148614 A1 WO 2018148614A1
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WO
WIPO (PCT)
Prior art keywords
composition
agent
amount
sodium
surfactants
Prior art date
Application number
PCT/US2018/017722
Other languages
English (en)
Inventor
Daniel H. Traynor
Laura E. COHEN
Original Assignee
CoLabs International Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/430,416 external-priority patent/US10322301B2/en
Priority claimed from PCT/US2017/017556 external-priority patent/WO2017139701A1/fr
Application filed by CoLabs International Corporation filed Critical CoLabs International Corporation
Publication of WO2018148614A1 publication Critical patent/WO2018148614A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
    • A01N25/28—Microcapsules or nanocapsules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0097—Dye preparations of special physical nature; Tablets, films, extrusion, microcapsules, sheets, pads, bags with dyes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0039—Coated compositions or coated components in the compositions, (micro)capsules
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Definitions

  • compositions comprising microcapsules enclosing one or more agents for the purpose of controlling their release is known in the pharmaceutical, medical, cosmetics, and other industries.
  • the microcapsules may additionally be surrounded by one or more agents.
  • Existing microcapsules tend to be rigid, such that application of mechanical force will cause the microcapsules to break, releasing the agents contained therewithin.
  • breakage of the microcapsules may reduce the effectiveness of the composition and release encapsulated agents.
  • the released agents may thereafter be undesirably absorbed into the body (e.g., through the skin) or absorbed all at once when a there is a need to absorb the active ingredients over a period of time.
  • the present invention addresses one or more of these needs by utilizing encapsulation technologies, milder surfactant systems, and good adhesive polymers that provide a strong binding capability, making it more efficient for deposition of the one ro more agents contained therein and/or therearound.
  • the disclosed capsules also lay down on the skin surface in a manner that result in packing and spreading of the agent over the skin surface or other portion of an individual.
  • the disclosed capsules also provide a means for formulating various agents that can result in a greater amount of agent after application through such products as shampoo, body wash, conditioner, lotion, mousse, spray, hand sanitizer, cream and gel.
  • compositions comprising one or more encapsulates comprising one or more agents and methods and uses for the disclosed agents.
  • the disclosed encapsulates can be cellulose derived encapsulates and/or sol-gel encapsulates.
  • the one or more agents include one or more moisturizing agents.
  • a composition disclosed herein may further comprise one or more flexible capsules comprising one or more polyquaterniums, one or more surfactants, one or more film formers, one or more emollients, one or more thickening agents, one or more soap bases, one or more polymers, one or more fragrances, or any combination thereof.
  • a composition disclosed herein may be incorporated into a body wash, a shampoo, an after-shower body lotion, a conditioner, a soap, a gel, a hand sanitizer, a cream, a spray, a mouse, a lotion, an ointment, a make-up product, a lip balm, a hair spray product, an arachnid/insect repellent or a medicinal product.
  • FIG. 1 shows a graph of dye penetration into human skin using fluorescence intensity of dye verus penetration depth of dye. Measurements were taken 30 minutes and 90 minutes after application of a composition.
  • FIG. 2 shows a graph of dye penetration into human skin using logio fluorescence intensity of dye verus penetration depth of dye. Data from the 30 minutes after application of a composition were used.
  • FIG. 3A shows a fluorescent image of dye penetration into human skin at 10 pm from the skin surface
  • FIG. 3B shows a fluorescent image of dye penetration into human skin at 50 pm from the skin surface
  • FIG. 3C shows a fluorescent image of dye penetration into human skin at 90 pm from the skin surface
  • FIG. 3D shows a bar graph of dye penetration into human skin usin ffluorescence intensity of dye versus penetration depth of dye.
  • FIG. 4 shows a bar graph comparing the amount of active agent needed to achieve an SPF value of 50.
  • compositions comprising one or more agents enclosed in a capsule (also referred to as "an encapsulate").
  • An agent includes, without limitation, an active agent and/or an additional agent disclosed herein.
  • encapsulation of an agent involves trapping the agent into a vesicle, such as, e.g., a microsphere (or microcapsule) or nanosphere (or nanocapsule).
  • a vesicle such as, e.g., a microsphere (or microcapsule) or nanosphere (or nanocapsule).
  • Encapsulation increases the stability of the composition by protecting the encapsulated agent.
  • encapsulation increases the effectiveness of the composition by creating a encapsulate layer that physically shield the skin layerand provides more complete coverage and even application.
  • encapsulation also minimizes the absorption of an agent disclosed herein into the dermis and subsequent systemic distribution in the body.
  • a capsule disclosed herein can have a flexible shell.
  • a flexible shell enables for the tight packing of the capsules on the surface of the skin to form an encapsulate layer, prevents breakage or rupture of the capsules upon friction or other external force and/or enables capsule to have high load rates.
  • applications involving a non-encapsulated agent is absorbed directly into the skin within about 1 hour. This is often undesireable or even detrimental because the benefits may be quickly lost and repeated applications are required to maintain adequate coverage of the agent.
  • absorption of some agents can be toxic to some degree and create health problems for the user.
  • Flexible capsules containing one or more agents form an encapsulation layer on top of the skin surface that acts as a protective barrier.
  • this encapsulate layer acts like a shield to physically protect a skin surface from harmful envormental exposure, such as, e.g. , sunlight, wind, dryness.
  • harmful envormental exposure such as, e.g. , sunlight, wind, dryness.
  • absorption into the skin is minimized.
  • This encapsulate layer appears to be maintained on the surface of skin for upwards of 8 or more hours.
  • a capsule disclosed herein is designed so as to experience minimal or no leakage of a agent disclosed herein, or decomposition when applied to the skin.
  • a capsule disclosed herein is eventually removed from the skin through repeated washing and/or normal sloughing of the external skin cell layers.
  • the invention provides a means to deliver a last line of defence on the skin of personnel where the active used in the microcapsules may be one that is not appropriate for long-term use, but that is appropriate for a limited number of applications in order to protect the wearer from a greater risk (e.g., cellulose derived capsule and/or sol-gel capsules, including, without limitation, microcapsules, encapsulating lead to protect against a radiation attack).
  • the active used in the microcapsules may be one that is not appropriate for long-term use, but that is appropriate for a limited number of applications in order to protect the wearer from a greater risk (e.g., cellulose derived capsule and/or sol-gel capsules, including, without limitation, microcapsules, encapsulating lead to protect against a radiation attack).
  • the mechanical properties at least some or all of the capsules may be selected to provide an exfoliating effect by acting as an exfoliant in the composition.
  • Exfolient compounds act an abrasive for sloughing away the outermost layer of dead skin cells from the epidermis, which may smooth the skin, promote blood circulation, and/or increase the turnover of surface skin cells.
  • At least some of the capsule materials are selected to be sufficiently hard to achive removal of the dead skin through mechanical exfoliation (e.g., by scubbing, etc.).
  • compositions may also be formulated with cationic polymer in a manner that causes the encapsulated agent to adhere or be trapped in a polymer complex to a skin surface, hair shaft, or any substrate which can accept an opposing charge forming a protective layer on the skin or other substrate.
  • the adhesive nature of the encapsulated agent enables the composition to remain on the skin's surface or other surface for longer periods of time relative to conventional compositions without the encapsulates and its packing capability, even after exposure to water or other liquids.
  • the active agent remained encapsulated, protection is not lost due to absorption of the active agent into the skin.
  • a composition disclosed herein can be manufactured as a solid, a liquid, a colloidal, or an aerosol.
  • a composition disclosed herein can be manufactured into, without limitation, a body wash, a shampoo, a conditioner, a soap, a gel, a hand sanitizer, a cream, a spray, a mouse or a lotion.
  • compositions may be easily and conveniently applied during normal hygienic activities, such as, e.g., washing, showering, bathing, after bathing or showering while the skin is still wet, or during routine moisturizing or other hygiene activities, resulting in the application of an effective level of an encapsulated active agent to a skin surface, even after activities that would remove conventional active agents, such as, e.g. , washing, rinsing, or swimming.
  • a capsule can be a cellulose derived capsule and/or a sol-gel capsule.
  • a composition disclosed herein may comprise a cellulose derived capsule comprising one or more agents disclosed herein.
  • a composition disclosed herein may comprise a sol-gel capsule comprising one or more agents disclosed herein.
  • a composition disclosed herein may comprise a cellulose derived capsule, a sol-gel capsule, each comprising one or more agents disclosed herein.
  • a cellulose derivative for use in a cellulose derived capsule includes without limitation, a cellulose ether or a cellulose ester.
  • a celluloe ether include ethyl cellulose, methyl cellulose, ethylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxyethylmethyl cellulose, hydroxypropylmethyl cellulose, ethyl hydroxyethyl cellulose, carboxymethyl cellulose, or any salt therefrom.
  • Non-limiting examples of a celluloe ester include cellulose acetate, cellulose acetate phthalate, cellulose acetate butyrate, cellulose acetate trimelitate, hydroxupropylmethyl cellulose phthalate, or any salt therefrom. Additional cellulose derivitiives are described in, e.g. , CELLULOSE: STRUCTURE AND PROPERTIES, DERIVITIVES AND INDUSTRIAL USES, eds. Lejeune and Deprez, pp. 528 (201 0); CELLULOSE AND CELLULOSE DERIVATIVES, Kenji Kamide, (2005); Doelker, Cellulose Derivatives, pp.
  • a cellulose derived capsule can be prepared in large quantities without a high reaction time and drying step and the preparation and purification of cellulose derived capsules are well known to a person skilled in the art, see, e.g., US Patents 8,039,01 5 and 8,685,425, each of which is incorporated by reference in its entirety.
  • a composition contains cellulose derived capsules comprising cellulose, a cellulose ether derivitieve, a cellulose eseter derivative, any salt therefrom, or any combination therefrom.
  • the cellulose derivative a composition contains cellulose derived capsules comprising cellulose, ethyl cellulose, methyl cellulose, ethylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxyethylmethyl cellulose, hydroxypropylmethyl cellulose, ethyl hydroxyethyl cellulose, carboxymethyl cellulose, cellulose acetate, cellulose acetate phthalate, cellulose acetate butyrate, cellulose acetate trimelitate, hydroxupropylmethyl cellulose phthalate, any salt therefrom, or any combination therefrom.
  • the cellulose derivative a composition contains cellulose derived capsules comprising cellulose, a cellulose ether derivitieve, any salt therefrom, or any combination therefrom.
  • the cellulose derivative a composition contains cellulose derived capsules comprising cellulose, ethyl cellulose, methyl cellulose, ethylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxyethylmethyl cellulose, hydroxypropylmethyl cellulose, ethyl hydroxyethyl cellulose, carboxymethyl cellulose, any salt therefrom, or any combination therefrom.
  • the cellulose derivative a composition contains cellulose derived capsules comprising cellulose, a cellulose eseter derivative, any salt therefrom, or any combination therefrom.
  • the cellulose derivative a composition contains cellulose derived capsules comprising cellulose, cellulose acetate, cellulose acetate phthalate, cellulose acetate butyrate, cellulose acetate trimelitate, hydroxupropylmethyl cellulose phthalate, any salt therefrom, or any combination therefrom.
  • the cellulose derivative used in a cellulose derived capsule is hydroxypropylcellulose or a salt therefrom.
  • the cellulose derivative used in a cellulose derived capsule is carboxymethylcellulose or a salt therefrom, such as, e.g. , sodium carboxymethyl cellulose.
  • a sol-gel capsules are prepared by emulsifying hydrophobic solution comprising sol-gel precursors and at least one active agents in an aqueous solution under high shear forces and mixing and stirring the obtained emulsion with a second aqueous solution at a suitably selected pH to obtain the sol- gel capsules.
  • the size of the microcapsules so obtained can be controlled, by selecting suitable reaction conditions.
  • the sol-gel precursors can be a metal or a semi-metal alkoxide monomers, or a partially hydrolyzed and partially condensed polymer thereof, or a mixture thereof.
  • the sol-gel precursors can be selected from metal or semi-metal alkoxide monomers, or metal ester monomers, or semi-metal ester monomers or monomers of the formula M(R) n (P)m, wherein M is a metallic or semi metallic element, R is a hydrolyzable substituent, n is an integer from 2 to 6, P is a non polymerizable substituent and m is and integer from 0 to 6, or partially hydrolyzed and partially condensed polymer thereof, or any mixture thereof.
  • a capsule disclosed herein has sufficient size to form a protective or desired layer on top of a skin surface after application of a composition disclosed herein. If capsules are too large, its size will reduce or disrupt the formation of an encapsulate layer, thereby reducing the packing of encapsulates which in turn will reduce coverage on the skin or other part of the body.
  • a capsule disclosed herein has a diameter of, e.g., at least 200 nm, at least 250 nm, at least 300 nm, at least 350 nm, at least 400 nm, at least 450 nm, at least 500 nm, at least 550 nm, at least 600 nm, at least 650 nm, at least 700 nm.
  • a cellulose derived capsule has a diameter of, e.g., at most 200 nm, at most 250 nm, at most 300 nm, at most 350 nm, at most 400 nm, at most 450 nm, at most 500 nm, at most 550 nm, at most 600 nm, at most 650 nm, at most 700 nm.
  • a capsule disclosed herein has a diameter of, e.g., about 200 nm to about 250 nm, about 200 nm to about 300 nm, about 200 nm to about 350 nm, about 200 nm to about 400 nm, about 200 nm to about 450 nm, about 200 nm to about 500 nm, about 200 nm to about 550 nm, about 200 nm to about 600 nm, about 200 nm to about 650 nm, about 200 nm to about 700 nm, about 250 nm to about 300 nm, about 250 nm to about 350 nm, about 250 nm to about 400 nm, about 250 nm to about 450 nm, about 250 nm to about 500 nm, about 250 nm to about 550 nm, about 250 nm to about 600 nm, about 250 nm to about 650 nm, about 250 nm.
  • a capsule disclosed herein can comprise one layer. In another embodiment, a capsule disclosed herein can comprise multiple layers. In aspects of this emboiment, a capsule discosed herein comprises two or more layers, three or more layers, four or more layers, or five or more layers.
  • a capsule disclosed herein is designed to not have one or more agents contained therein to be absorb or otherwise penetrate, or minimize such absorption/penetration, into the epidermal layer of the skin. In an embodiment, a capsule disclosed herein is designed to not have one or more agents contained therein absorbed or otherwise penetrate through the epidermal layer of the skin. In aspets of this embodiment, a capsule disclosed herein is designed to not have one or more agents contained therein to be substantially absorbed or otherwise penetrate through the stratum corneum into the live epidermal layer of the skin. In aspects of this embodiment, a capsule disclosed herein is designed to have only, e.g. , at most 1 %, at most 5%, at most 10%, at most 15%, at most 20% or at most 25% of the one or more agents absorbed or otherwise penetrate through the stratum corneum into the live epidermal layer of the skin.
  • an agent disclosed herein may be absorbed or otherwise penetrate the epidermal layer of the skin by only, e.g. , about 0.1 ⁇ , about 0.5 ⁇ , about 1 ⁇ , about 5 ⁇ , about 10 ⁇ , about 15 ⁇ , about 20 ⁇ , about 30 ⁇ , about 40 ⁇ , about 50 ⁇ , about 60 ⁇ , about 70 ⁇ , about 80 ⁇ , about 90 ⁇ or about 100 ⁇ .
  • an agent disclosed herein may be absorbed or otherwise penetrate the epidermal layer of the skin by only, e.g.
  • an agent disclosed herein may be absorbed or otherwise penetrate the epidermal layer of the skin by only, e.g., about 0.1 mm to about 1 ⁇ , about 0.1 mm to about 5 ⁇ , about 0.1 mm to about 10 ⁇ , about 0.1 mm to about 15 ⁇ , about 0.1 mm to about 20 ⁇ , about 0.1 mm to about 25 ⁇ , about 0.1 mm to about 30 ⁇ , about 0.1 mm to about 40 ⁇ , about 0.1 mm to about 50 ⁇ , about 0.1 mm to about 60 ⁇ , about 0.1 mm to about 70 ⁇ , about 0.1 mm to about 80 ⁇ , about 0.1 mm to about 90 ⁇ , about 0.1 mm to about 100 ⁇ , about 0.5 mm to about 1 ⁇ , about 0.5 mm to about 5 ⁇ , about 0.5 mm to about 10 ⁇ , about 0.5 mm to about 15 ⁇ , about 0.5 mm to about 20 ⁇ , about 0.5 mm to about 25
  • a capsule disclosed herein may be designed to be stable or unstable. Stability includes mechanical stability as well as photostability (providing stabilization of photosensitive drugs). Mechanical stability refers to the degree of encapsulate breakage or disintegrate following exposure to physical forces. Photostability refers to the degree of encapsulate breakage or disintegrate following exposure to the sun or UV radiation. Upon breakage of encapsulates their internal contents, including, an active agent, and/or a photostabilizing agent, and/or an additional agent disclosed herein are released onto a skin surface.
  • a capsule disclosed herein is prepared so to experience no or minimal breakage when applied to a skin surface.
  • a capsule disclosed herein is prepared so to experience various degrees of breakage, on average, when applied to a skin.
  • a capsule disclosed herein is formulated so as to break open in response to conditions that occur on a skin surface, so that after application the capsules act to release their contents in a time- release or controlled manner.
  • skin or hair conditions can vary with the user's environment, a variation which can trigger breakage of capsules, include, without limitation, dryness of the skin surface, dryness of hair, pH, temperature, friction, exposure to light and exposure to air.
  • a capsule disclosed herein may be prepared so as to experience about 0% breakage, or breakage in a range of from about 1 % to about 100%.
  • a capsule disclosed herein may be prepared so as to experience breakage of, e.g., at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70, at least 80%, at least 90%, or at least 95% after application to a skin surface.
  • a capsule disclosed herein may be prepared so as to experience breakage of, e.g., at most 10%, at most 20%, at most 30%, at most 40%, at most 50%, at most 60%, at most 70, at most 80%, at most 90%, or at most 95% after application to a skin surface.
  • a capsule disclosed herein may be prepared so as to experience breakage in a range of, e.g., about 10% to about 20%, about 10% to about 30%, about 10% to about 40%, about 10% to about 50%, about 10% to about 60%, about 10% to about 70%, about 10% to about 80%, about 10% to about 90%, about 10% to about 100%, about 20% to about 30%, about 20% to about 40%, about 20% to about 50%, about 20% to about 60%, about 20% to about 70%, about 20% to about 80%, about 20% to about 90%, about 20% to about 100%, about 30% to about 40%, about 30% to about 50%, about 30% to about 60%, about 30% to about 70%, about 30% to about 80%, about 30% to about 90%, about 30% to about 100%, about 40% to about 50%, about 40% to about 60%, about 40% to about 70%, about 40% to about 80%, about 40% to about 90%, about 40% to about 100%, about 50% to about 60%, about 50% to about 70%, about 50% to about 80%, about 50% to about 90%, about 50% to about 100%, about 60% to about 70%
  • a moisturizing agent prevents loss of moisture and/or hydrates the skin and/or increases the water content of the skin and/or replaces the oils contained in the skin.
  • a moisturizing agent includes, without limitation, an occulusive, which works by forming a thin film on the surface of the skin to prevent moisture loss, a humectant, which attracts water vapor from the air to moisturize the skin, and a restoration agent, which restore natural moisturizing factors to the skin.
  • a moisturizing agent includes, without limitation, an emollient, which works by softening or soothing the skin.
  • a moisturizing agent can be used as an after-care treatment of excessive sun exposure or sunburn.
  • a moisturizing agent includes, without limitation, glycerin, chamomile, aloe, cetyl alcohol, grape seed oil, dimethicone, an a-hydroxy acid, a silicone-based agent, a petrolatum-based agent and an antioxidant.
  • a silicone-based agent includes, without limitation, cyclopentasiloxane, cyclohexasiloxane, cyclomethicone, dimethicone and phenyl trimethicone.
  • Non-limiting examples of moisturizing agents that can be used with the compositions of the present invention include amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, glucose, glycerin, glycerol polymers, glycol, 1 ,2,6-hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factor, PEG-15 butanediol, polyglyceryl sorbitol, saccharide isomerate, salts of pyrrolidone carboxylic acid, potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol.
  • An ohydroxy acid includes, without limitation, glycolic acid, lactic acid, malic acid, citric acid and tartaric acid.
  • An antioxidant includes, without limitation, 6-Hydroxymelatonin, acetyl-L-carnitine, a carotene, curcumin, edaravone, glutathione, hydroxytyrosol, L-carnitine, ladostigil, a lipoic acid like a- lipoic acid, melatonin, mofegiline, N-acetylcysteine, N-acetylserotonin, oleocanthal, oleuropein, a polyphenol, rasagiline, resveratrol, selegiline, selenium, tirlazad, tyrosol, uric acid, ubiquinol, ubiquinone, a vitamin A like a carotenoid, a vitamin C like an ascorbic acid, and a vitamin E like a to
  • an encapsulated moisturizing agents such as glycerin
  • a free moisturizing agent non-encapsulated
  • the encapsulates form a layered barrier on the skin that prevents drying and keeps moisture within the skin.
  • the breakage releases the moisturizing agents contained within the ruptured encapsulate.
  • one or more one or more moisturizing agents disclosed herein are encapsulated. In aspects of this embodiment, one or more moisturizing agents disclosed herein are encapsulated in a cellulose derived capsule. In other aspects of this embodiment, one or more moisturizing agents disclosed herein are encapsulated in a cellulose derived capsule and one or more moisturizing agents disclosed herein are not encapsulated. In aspects of this embodiment, one or more moisturizing agents disclosed herein are encapsulated in a sol-gel capsule. In other aspects of this embodiment, one or more moisturizing agents disclosed herein are encapsulated in a sol-gel capsule and one or more moisturizing agents disclosed herein are not encapsulated.
  • a moisturizing agent and/or an additional agent disclosed herein is encapsulated in a cellulose derived capsule.
  • one or more moisturizing agents and/or additional agents and disclosed herein are encapsulated in a cellulose derived capsule and one or more moisturizing agents and/or one or more additional agents disclosed herein are not encapsulated.
  • one or more additional agents disclosed herein are not encapsulated.
  • one or more one or more moisturizing agents disclosed herein are encapsulated, but one or more additional agents disclosed herein are not encapsulated.
  • a moisturizing agent and/or an additional agent disclosed herein is encapsulated in a sol-gel capsule.
  • one or more moisturizing agents and/or additional agents and disclosed herein are encapsulated in a sol-gel capsule and one or more moisturizing agents and/or one or more additional agents disclosed herein are not encapsulated.
  • one or more additional agents disclosed herein are not encapsulated.
  • one or more one or more moisturizing agents disclosed herein are encapsulated, but one or more additional agents disclosed herein are not encapsulated.
  • a moisturizing agent and/or an additional agent disclosed herein is encapsulated in a cellulose derived capsule and a sol-gel capsule.
  • one or more moisturizing agents and/or additional agents and disclosed herein are encapsulated in a cellulose derived capsule and a sol-gel capsule and one or more moisturizing agents and/or one or more additional agents disclosed herein are not encapsulated.
  • one or more additional agents disclosed herein are not encapsulated.
  • one or more one or more moisturizing agents disclosed herein are encapsulated, but one or more additional agents disclosed herein are not encapsulated.
  • a moisturizing agent and, optionally, an additional agent disclosed herein is encapsulated in a cellulose derived capsule; and an additional agent disclosed herein is encapsulated in a sol-gel capsule.
  • a moisturizing agent and, optionally, an additional agent disclosed herein is encapsulated in a sol-gel capsule; and an additional agent disclosed herein is encapsulated in a cellulose derived capsule.
  • a first moisturizing agent and, optionally, an additional agent disclosed herein is encapsulated in a cellulose derived capsule; and at least a second moisturizing agent and, optionally, an additional agent disclosed herein is encapsulated in a sol-gel capsule.
  • An arachnid/insect repellent active agent includes, without limitation, a synthetic chemical compound or a compound purified from a natural source.
  • Non-limiting examples of an arachnid/insect repellent that is a synthetic chemical compound include, without limitation, N,N-Diethyl-m-toluamide (DEET), dimethyl phthalate, ethyl hexanediol, indalone, di-n-propylisocinchoronate, bicycloheptene, dicarboximide, dimethyl carbate, dimethyl phthalate, metofluthrin, indalone, permethrin, icaridin, nepetalactone, tetrahydrofuraldehyde ethyl butylacetylaminopropionate (IR-3535), p-menthane-3,8-diol (PMD), tricyclodecenyl allyl ether, ethylhexanediol, SS220 ((1 S,2'S)-Methylpiperidinyl-3-cyclohexen-
  • methyl anthranilate ⁇ , ⁇ -dimethylanthranilic acid (DMA), ethyl anthranilate (EA), and butyl anthranilate (BA) and hydroxyethyl isobutyl piperidine carboxylate.
  • DMA methyl anthranilate
  • EA ethyl anthranilate
  • BA butyl anthranilate
  • Non-limiting examples of an arachnid/insect repellent that is a compound purified from a natural source includes plant-derived materials and sea-life including fish.
  • Plant-derived materials with arachnid/insect repellent activity include, without limitation, plant oils derived from, e.g. , achillea, Andrographis paniculata, anise, basil, bay, bergamot (e.g.
  • Monardia fistulosa Monarda didyma, Citrus bergamia, Monarda punctata), bitter orange peel, black pepper, calamus, camphor, cananga (e.g., java), cardamom, carnation (e.g., dianthus caryophyllus), cassia, castor, cedar (e.g., hinoki), cedarwood, celery, chamomile, cinnamon, Citrus aurantium amara, Citrus aurantium dulcis, Citrus unshiu, clary sage, clove (e.g., eugenia caryophyllus), clove bud, coriander, corn, cotton seed, Cymbopogon martini, eucalyptus, lemon eucalyptus, evening primrose, fennel, garlic, geranium, ginger, grapefruit, guaiacwood, gurjun balsam, hiba, jasmine,
  • a plant oil or derivative thereof may be extracted from a natural source or synthetically made and include racemic mixtures, enantiomers, diastereomers, hydrates, salts, solvates and metabolites, etc.
  • Such oils generally contains as a major constituent an acyclic monoterpene alcohol or aldehyde, a benzenoid aromatic compound containing at least one oxygenated substituent or side chain, or a monocarbocyclic terpene generally having a six membered ring bearing one or more oxygenated substituents.
  • suitable plant oils disclosed herein include, without limitation, a- or ⁇ -pinene; a-campholenic aldehyde; a-citronellol; a-iso-amyl-cinnamic; a-pinene oxide; a-cinnamic terpinene; a- terpineol (e.g., 1 -methyl-4-isopropyl-1 -cyclohexen-8-ol); a-terpinene; ⁇ -terpinene; aldehyde C16 (pure); a- phellandrene; amyl cinnamic aldehyde; amyl salicylate; anethole; anisic aldehyde; benzyl acetate; benzyl alcohol; borneol; callicarpenal; carvacrol; carveol; cineole; cinnamaldehyde; cinnamic alcohol; cis
  • an arachnid/insect repellent active agent and/or an additional agent disclosed herein is encapsulated in a capsule.
  • one or more arachnid/insect repellent active agents and/or additional agents and disclosed herein are encapsulated in a cellulose derived capsule.
  • one or more arachnid/insect repellent active agents and/or additional agents and disclosed herein are encapsulated in a cellulose derived capsule and one or more arachnid/insect repellent active agents and/or one or more additional agents disclosed herein are not encapsulated.
  • one or more additional agents disclosed herein are not encapsulated.
  • an arachnid/insect repellent active agent and/or an additional agent disclosed herein is encapsulated in a cellulose derived capsule.
  • one or more arachnid/insect repellent active agents and/or additional agents and disclosed herein are encapsulated in a cellulose derived capsule and one or more arachnid/insect repellent active agents and/or one or more additional agents disclosed herein are not encapsulated.
  • one or more one or more arachnid/insect repellent active agents disclosed herein are encapsulated, but one or more additional agents disclosed herein are not encapsulated.
  • an arachnid/insect repellent active agent and/or an additional agent disclosed herein is encapsulated in a sol-gel capsule.
  • one or more arachnid/insect repellent active agents and/or additional agents and disclosed herein are encapsulated in a sol-gel capsule and one or more arachnid/insect repellent active agents and/or one or more additional agents disclosed herein are not encapsulated.
  • an arachnid/insect repellent active agent and/or an additional agent disclosed herein is encapsulated in a sol-gel capsule.
  • one or more arachnid/insect repellent active agents and/or additional agents and disclosed herein are encapsulated in a sol-gel capsule and one or more arachnid/insect repellent active agents and/or one or more additional agents disclosed herein are not encapsulated.
  • one or more additional agents disclosed herein are not encapsulated.
  • one or more one or more arachnid/insect repellent active agents disclosed herein are encapsulated, but one or more additional agents disclosed herein are not encapsulated.
  • an arachnid/insect repellent active agent and/or an additional agent disclosed herein is encapsulated in a cellulose derived capsule and a sol-gel capsule.
  • one or more arachnid/insect repellent active agents and/or additional agents and disclosed herein are encapsulated in a cellulose derived capsule and a sol-gel capsule and one or more moisturizing agents and/or one or more additional agents disclosed herein are not encapsulated.
  • one or more additional agents disclosed herein are not encapsulated.
  • one or more one or more arachnid/insect repellent active agents disclosed herein are encapsulated, but one or more additional agents disclosed herein are not encapsulated.
  • an arachnid/insect repellent active agent and, optionally, an additional agent disclosed herein is encapsulated in a cellulose derived capsule; and an additional agent disclosed herein is encapsulated in a sol-gel capsule.
  • an arachnid/insect repellent active agent and, optionally, an additional agent disclosed herein is encapsulated in a sol-gel capsule; and an additional agent disclosed herein is encapsulated in a cellulose derived capsule.
  • a first arachnid/insect repellent active agent and, optionally, an additional agent disclosed herein is encapsulated in a cellulose derived capsule; and at least a second arachnid/insect repellent active agent and, optionally, an additional agent disclosed herein is encapsulated in a sol-gel capsule.
  • a composition disclosed herein comprises a cationic polymer to enhance the overall positive charge of the one or more active agents and/or additional agents encapsulated in a cellulose derived capsule or a sol-gel capsule.
  • the overall net positive charge of encapsulates promote and facilitate an electrostatic binding or attachment of encapsulates to a negatively charged molecule or surface, such as, e.g. , charged components of skin and/or hair.
  • a cationic polymer disclosed herein is not encapsulated by a cellulose derived capsule or a sol-gel capsule disclosed herein.
  • a cationic polymer useful in a composition disclosed herein include, without limitation, POLYMER JR (Union Carbide Corp.), a cationic cellulose ether derivative, JAGUAR ® (Celanese-Stein Hall), cationic guar gums, GAFQUATM (GAF Corporation), quaternary vinylpyrrolidone copolymer, CAE (Anjinomoto Co., Inc.), a DL-pyrrolidone carboxylic acid salt of L-cocoyl arginine ethyl ester, and MERQUATTM (Merck & Co.), including MERQUATTM 100, a highly charged cationic polymer prepared with dimethyldiallylammonium chloride homopolymer, and MERQUATTM 550, a highly charged cationic copolymer prepared with dimethyldiallylammonium chloride and acrylamide.
  • a cationic polymer includes, without limitation, a quaternium or a polyquaternium.
  • a cationic polymer useful in a composition disclosed herein are also described in, e.g., U.S. Patents 6,224,852; 3,816,616; 4,272,515; 4,298,494; 4,080,310; 4,048,301 ; 4,009,256; and 3,186,91 1 , each of which is hereby incorporated by reference in its entirety.
  • a composition disclosed herein comprises a cationic polymer in an amount sufficient to confer an overall positive charge of the one or more active agents and/or additional agents encapsulated in a cellulose derived capsule or a sol-gel capsule that promotes and facilitates an electrostatic binding or attachment of the encapsulates to a negatively charged molecule or surface, such as, e.g., charged components of skin and/or hair.
  • a composition disclosed herein comprises a cationic polymer in an amount of, e.g., at least 0.1 %, at least 0.2%, at least 0.3%, at least 0.4%, at least 0.5%, at least 0.6%, at least 0.7%, at least 0.8%, at least 0.9%, at least 1.0%, at least 2.0%, at least 3.0%, at least 4.0%, at least 5.0%, at least 6.0%, at least 7.0%, at least 8.0%, at least 9.0%, at least 10%, at least 11 %, at least 12%, at least 13%, at least 14%, at least 15%, at least 20%, at least 25% of the total weight of the composition.
  • a composition disclosed herein comprises a cationic polymer in an amount of, e.g., at most 0.1 %, at most 0.2%, at most 0.3%, at most 0.4%, at most 0.5%, at most 0.6%, at most 0.7%, at most 0.8%, at most 0.9%, at most 1 .0%, at most 2.0%, at most 3.0%, at most 4.0%, at most 5.0%, at most 6.0%, at most 7.0%, at most 8.0%, at most 9.0%, at most 10%, at most 11 %, at most 12%, at most 13%, at most 14%, at most 15%, at most 20%, at most 25% of the total weight of the composition.
  • a composition disclosed herein comprises a cationic polymer in an amount of, e.g., about 0.1 % to about 0.5%, about 0.1 % to about 1 .0%, about 0.1 % to about 2.0%, about 0.1 % to about 3.0%, about 0.1 % to about 4.0%, about 0.1 % to about 5.0%, about 0.1 % to about 6.0%, about 0.1 % to about 7.0%, about 0.1 % to about 8.0%, about 0.1 % to about 9.0%, about 0.1 % to about 10%, about 0.5% to about 1 .0%, about 0.5% to about 2.0%, about 0.5% to about 3.0%, about 0.5% to about 4.0%, about 0.5% to about 5.0%, about 0.5% to about 6.0%, about 0.5% to about 7.0%, about 0.5% to about 8.0%, about 0.5% to about 9.0%, about 0.5% to about 10%, about 1 .0% to about 2.0%, about 1 .0% to about 3.0%, about 0.5% to about 4.0%, about 0.5% to about 5.0%, about
  • a composition disclosed herein comprises a film former.
  • a film former creates a hydrophobic layer on a skin surface and/or hair that acts as a barrier which promotes and enhances the retention of the one or more encapsulated active agents and/or additional agents, even after exposure to water or other liquids, such as, e.g. , by washing , rinsing, or swimming.
  • a film former disclosed herein is not encapsulated by a cellulose derived capsule or a sol-gel capsule disclosed herein.
  • Non-limiting examples of a film former include an acrylic co-polymer, butylated hydroxytoluene (BHT), dimethicone, a lanolin derivative, petrolatum, a polyethylene, a polymer, a silicon derivative, a superfatted oil, a water- insoluble emollient, and a keratin or other protein derivative in an amino acid complex such as cysteine.
  • Non-limiting examples of a lanolin derivative include an acetylated lanolin.
  • Non-limiting examples of a water-insoluble emollient includes, fatty acids such as, e.g., oleic and stearic; fatty alcohols such a as, e.g. , s cetyl, and hexadecyl (ENJAY); cocoa butter; shea oil; emollient esters such as, e.g., diisopropyl adipate, benzoic acid esters of alcohols, and isononyl iso- nonanoate; alkanes such as, e.g., mineral oil; silicones; such as, e.g. , dimethyl polysiloxane and emollient ethers such as, e.g., polyoxypropylene butyl ethers and polyoxypropylene cetyl ethers.
  • fatty acids such as, e.g., oleic and stearic
  • fatty alcohols such a as, e.g.
  • Non-limiting examples of a polyethylene including, without limitation, PERFORMALENE ® 400 (New Phase Technologies), a polyethylene having a molecular weight of 400 and PERFORMALENE ® 2000 (New Phase Technologies) a polyethylene having a molecular weight of 2000.
  • a film former examples include acacia gum, cellulose derivatives, guar derivatives, acrylamides copolymer, acrylamide/sodium aciylate copolymer, acrylate/acrylamide copolymer, acrylate/ammonium methacrylate copolymer, acrylates copolymer, acrylates/diacetoneacrylamide copolymer, acrylic/acrylate copolymer, adipic acid/dimethylaminohydroxypropyl diethlenetnamine copolymer, adipic acid/epoxypropyl/diethlenetriamine copolymer, albumen, allyl stearate/VA copolymer, aminoethylacrylate phosphate/acrylate copolymer, ammonium acrylates copolymer, ammonium alginate, ammonium vinyl acetate/acrylates copolymer, AMP acrylates/diacetoneacrylamide copolymer, balsam Canada
  • a film former useful in a composition disclosed herein include, without limitation, petroleum, an acrylate copolymer (DERMACRYL ® 2.0, DERMACRYL ® 79, DERMACRYL ® AQF, DERMACRYL ® C, DERMACRYL ® E), a synthetic wax of branched polyalpha olefin polymers (PERFORMA ® V 103, 260, 343, 825, 6038), a olefin/undecylenic acid copolymer (PERFORMA ® V 61 12) or MOISTUREGUARDTM (Engelhard), a film former comprising petrolatum, dimethicone, stearamidopropyl dimethylamine, stearate and tocopheryl acetate.
  • DERMACRYL ® 2.0, DERMACRYL ® 79, DERMACRYL ® AQF, DERMACRYL ® C, DERMACRYL ® E a synthetic wax of branched poly
  • a film former useful in a composition disclosed herein are also described in, e.g., U.S. Patents 6,838,419, 6,838,088, 6,780,422, 6,531 ,1 18, and 5,916,541 , each of which is incorporated herein by reference in its entirety.
  • a composition disclosed herein comprises a film former in an amount sufficient to create a hydrophobic layer on a skin surface and/or hair that acts as a barrier which promotes and enhances the retention of the one or more encapsulated active agents and/or additional agents, even after exposure to water or other liquid.
  • a composition disclosed herein comprises a film former in an amount of, e.g., at least 0.1 %, at least 0.2%, at least 0.3%, at least 0.4%, at least 0.5%, at least 0.6%, at least 0.7%, at least 0.8%, at least 0.9%, at least 1 .0%, at least 2.0%, at least 3.0%, at least 4.0%, at least 5.0%, at least 6.0%, at least 7.0%, at least 8.0%, at least 9.0%, at least 10%, at least 11 %, at least 12%, at least 13%, at least 14%, at least 15%, at least 20%, at least 25%, at least 30%, at least 35% or at least 40% of the total weight of the composition.
  • a composition disclosed herein comprises a film former in an amount of, e.g. , at most 0.1 %, at most 0.2%, at most 0.3%, at most 0.4%, at most 0.5%, at most 0.6%, at most 0.7%, at most 0.8%, at most 0.9%, at most 1.0%, at most 2.0%, at most 3.0%, at most 4.0%, at most 5.0%, at most 6.0%, at most 7.0%, at most 8.0%, at most 9.0%, at most 10%, at most 1 1 %, at most 12%, at most 13%, at most 14%, at most 15%, at most 20%, at most 25%, at most 30%, at most 35% or at most 40% of the total weight of the composition.
  • a composition disclosed herein comprises a film former in an amount of, e.g., about 0.1 % to about 0.5%, about 0.1 % to about 1 .0%, about 0.1 % to about 2.0%, about 0.1 % to about 3.0%, about 0.1 % to about 4.0%, about 0.1 % to about 5.0%, about 0.1 % to about 6.0%, about 0.1 % to about 7.0%, about 0.1 % to about 8.0%, about 0.1 % to about 9.0%, about 0.1 % to about 10%, about 0.5% to about 1 .0%, about 0.5% to about 2.0%, about 0.5% to about 3.0%, about 0.5% to about 4.0%, about 0.5% to about 5.0%, about 0.5% to about 6.0%, about 0.5% to about 7.0%, about 0.5% to about 8.0%, about 0.5% to about 9.0%, about 0.5% to about 10%, about 1 .0% to about 2.0%, about 1 .0% to about 3.0%, about 1.0% to about 4.0%, about 1
  • a composition disclosed herein comprises can further comprise a surfactant metal complex to enhance the reflective property or create a reflective property of a composition disclosed herein.
  • a surfactant metal complex disclosed herein is not encapsulated by a cellulose derived capsule disclosed herein.
  • a composition disclosed herein comprises a surfactant metal complex in an amount sufficient to promote or facilitate the reflection of UV light.
  • a composition disclosed herein comprises a surfactant metal complex in an amount of, e.g., at least 0.1 %, at least 0.2%, at least 0.3%, at least 0.4%, at least 0.5%, at least 0.6%, at least 0.7%, at least 0.8%, at least 0.9%, at least 1 .0%, at least 2.0%, at least 3.0%, at least 4.0%, at least 5.0%, at least 6.0%, at least 7.0%, at least 8.0%, at least 9.0%, at least 10%, at least 11 %, at least 12%, at least 13%, at least 14%, at least 15%, at least 20%, at least 25% of the total weight of the composition.
  • a composition disclosed herein comprises a surfactant metal complex in an amount of, e.g., at most 0.1 %, at most 0.2%, at most 0.3%, at most 0.4%, at most 0.5%, at most 0.6%, at most 0.7%, at most 0.8%, at most 0.9%, at most 1.0%, at most 2.0%, at most 3.0%, at most 4.0%, at most 5.0%, at most 6.0%, at most 7.0%, at most 8.0%, at most 9.0%, at most 10%, at most 11 %, at most 12%, at most 13%, at most 14%, at most 15%, at most 20%, at most 25% of the total weight of the composition.
  • a composition disclosed herein comprises a surfactant metal complex in an amount of, e.g. , about 0.1 % to about 0.5%, about 0.1 % to about 1 .0%, about 0.1 % to about 2.0%, about 0.1 % to about 3.0%, about 0.1 % to about 4.0%, about 0.1 % to about 5.0%, about 0.1 % to about 6.0%, about 0.1 % to about 7.0%, about 0.1 % to about 8.0%, about 0.1 % to about 9.0%, about 0.1 % to about 10%, about 0.5% to about 1 .0%, about 0.5% to about 2.0%, about 0.5% to about 3.0%, about 0.5% to about 4.0%, about 0.5% to about 5.0%, about 0.5% to about 6.0%, about 0.5% to about 7.0%, about 0.5% to about 8.0%, about 0.5% to about 9.0%, about 0.5% to about 10%, about 1 .0% to about 2.0%, about 1 .0% to about 3.0%, about 0.5% to about 4.0%, about 0.5% to about 5.0%,
  • a composition comprising one or more active agents may further include one or more photostabilizing agents.
  • Some active agents are photosensitive and are susceptible to photochemically- initiated degradation reactions, e.g., such as a sunscreen active agent.
  • a photostabilizing agent stabilizes against light-induced degradation and help prevent and active agent disclosed herein from losing its effectiveness or integrity.
  • photostabilizing agent helps stabilize and active agent disclosed herein structurally and geometrically through electrostatic and van der Waals interactions, which insulate the active agent from being altered during the chemical reaction.
  • Another type of photostabilizing agent protects an active agent disclosed herein by dissipating the energy from UV radiation more quickly, thus reducing or even eliminating the possibility of a chemical reaction. This process is called energy transfer, and it can take place when an active agent disclosed herein and photostabilizing agent exchange electrons.
  • a photostabilizing agent enables the use of less of certain active agents, for example, sunscreen active agents, which increases the safety of a composition disclosed herein by reducing the amount of the active agent is used, thereby reducing the amount of the active agent that can be absorbed into the body and systemically distributed. In addition, reducing the amount of the active agent also reduces the overall cost of making a composition disclosed herein.
  • Non-limiting examples of a photostabilizing agent include 4-methylbenzylidene camphor (MBC), an ⁇ -o!efin copolymer, Bemotrizinol (BTZ), Galangal extract, ethylhexyl methoxycrylene (SOLASTAY ® S1), a hindered amine light stabilizer [HALS, 2,2,6,6-tetramethyl piperidine-based compounds including TINUVIN ® compounds (BASF), CHIMASSORB ® compounds (BASF) and LA compounds (Amfine)], hexylresorcinol, Polyester-25 (a bis-Methoxycrylene/octyldodecyl adipic acid/methylpropanediol copolymer)(SOLASTAY ® P1), octasalicyalte (octasalate), trimethoxybenzylidene pentanedione (SYNOXYL ® HSS, Sytheon
  • Photostabilizing agents useful in a composition disclosed herein are also described in, e.g., U.S. Patent 5,801 ,244 and U.S. Patent Publications 2009/0074684 and 2013/0059924, each of which is incorporated herein by reference in its entirety.
  • a composition comprising one or more active agents may further include one or more other additional agents.
  • an additional agents disclosed herein provides a benfit different than or complementeary to the one or more active agents, and/or provides a minimally similar benfit.
  • An additional agent disclosed herein includes, without limitation, a sunscreen agent, an analgesic agent, an aesthetic agent, an anti-acne agent, an anti-allergenic agent, an anti-cellulite agent, an anti-inflammatory agent, an antioxidant, an anti-pruritic agent, an anti-skin aging agent, an anti-skin wrinkling agent, an anti-microbial agent (e.g., antifungals, antibacterials, and antiparasitics), an anti-viral agent, a jellyfish repellent agent, a chelating agent, a deodorant, a dye, an essential oil, a hair growth promoter, a hair growth inhibitor, a hair bleaching agent, an anti-lice agent, an arachnid/insect repellent, a lipid, a medicinal agent (e.g., a biologic, a pharmaceutically active ingredient), a moisturizing agent, a pest repellent, a preservative, a silicone containing compound, a liquid hydrocarbon,
  • a cooling agent or a heating agent skin whitening agent (e.g., a skin bleaching agent and a skin lightening agent), a skin nourishing agent, a structuring agent, a sunscreen agent, a sunless tanning agent, a thickening agent, a vitamin, (e.g., skin rash, skin disease and dermatitis medications) or other molecule useful in protecting, moisturizing or otherwise enhancing the health and appearance of a skin surface or hair.
  • skin whitening agent e.g., a skin bleaching agent and a skin lightening agent
  • a skin nourishing agent e.g., a structuring agent
  • a sunscreen agent e.g., a sunless tanning agent, a thickening agent, a vitamin, (e.g., skin rash, skin disease and dermatitis medications) or other molecule useful in protecting, moisturizing or otherwise enhancing the health and appearance of a skin surface or hair.
  • An aesthetic agent includes, without limitation, benzalkonium chloride, butamben picrate, benzocaine, bupivacaine, calamine, chlorprocaine, cocaine, dibucaine, dyclonine, etidocaine, hexylcaine, ketamine, lidocaine, mepivacaine, menthol, procaine, pramoxine, prilocaine, phenol, pramoxiine, tetracaine, xylocalne, and pharmaceutically acceptable salts thereof.
  • An analgesic agent includes, without limitation, dyclonine hydrochloride, aloe vera, fentanyl, capsaicin, and the like.
  • An anti-acne actives include, without limitation, 5,7-dichloro-8-hydroxyquinoline, adapalene, azaleic acid, benzoyl peroxide, clindamycin, dapsone, erythromycin, long chain dicarboxylic acids, hydrocortisone, resorcinol, resorcinol acetate, salicylic acid, sulphur, tretinoin, urea, zinc, various natural agents such as those derived from green tree, and more.
  • suitable antiacne actives for use herein are described in U.S. Patent 5,607,980, which is hereby incorporated by reference in its entirety.
  • An anti-allergenic agent includes, without limitation, antihistamines.
  • antihistamines are, without limitation, Hi or H2 antagonists or other types of histamine release inhibitors.
  • Hi antagonists are sedating or non-sedating, including, without limitation, diphenhydramine (Benadryl), chlorpheniramine, tripelennamine, promethazine, clemastine, doxylamine, benadryl and more.
  • Hi-non-sedating antihistamines include, without limitation, astemizole, terfenadine, loratadine etc.
  • H2 antagonists include cimetadine, famotidine, nizatidine, and ranitidine.
  • histamine-release-inhibitors include, without limitation, cromolyn.
  • An anticellulite agent includes, without limitation, isobutylmethylxanthine, caffeine, theophylline, theobromine, aminophylline, yohimbine, and mixtures thereof.
  • actives suitable for treating hair loss include, without limitation, potassium channel openers or peripheral vasodilators such as minoxidil, diazoxide, and compounds such as N*-cyano-N-(tert-pentyl)-N'-3-pyridinyl- guanidine ("P-1075") as disclosed in U.S. Pat. No.
  • vitamins such as vitamin E and vitamin C, and derivatives thereof such as vitamin E acetate and vitamin C palmitate; hormones, such as erythropoietin, prostaglandins, such as prostaglandin El and prostaglandin F2-a; fatty acids, such as oleic acid; diruretics such as spironolactone; heat shock proteins ("HSP"), such as HSP 27 and HSP 72; calcium channel blockers, such as verapamil HCL, nifedipine, and diltiazemamiloride; immunosuppressant drugs, such as cyclosporin and Fk-506; 5a-reductase inhibitors such as finasteride; growth factors such as, EGF, IGF and FGF; transforming growth factor ⁇ ; tumor necrosis factor; non-steroidal anti-inflammatory agents such as benoxaprofen; retinoids such as tretinoin; cytokines, such as
  • Preferred hair loss treatment agents include minoxidil, 6-(l-piperdinyl)-2,4-pyrimidinediamine-3-oxide, N'-cyano-N-(tert- pentyl)-N'-3-pyridinyl-guanidine, finasteride, retinoids and derivatives thereof, ketoconazole, elubiol or mixtures thereof.
  • An anti-inflammatory agent includes, without limitation, steroidal, non-steroidal, and other compounds.
  • steroidal anti-inflammatory agents include, without limitation, corticosteroids such as hydrocortisone, hydroxyltriamcinolone, a-methyl dexamethasone, dexamethasone-phosphate, beclomethasone dipropionates, clobetasol valerate, desonide, desoxymethasone, desoxycorticosterone acetate, dexamethasone, dichlorisone, diflorasone diacetate, diflucortolone valerate, fluadrenolone, fluclorolone acetonide, fludrocortisone, flumethasone pivalate, fluosinolone acetonide, fluocinonide, flucortine butylesters, fluocortolone, fluprednidene (fluprednylidene) acetate, flurand
  • a nonsteroidal anti-inflammatory agent includes, without limitation, oxicams (e.g., piroxicam, isoxicam, tenoxicam, sudoxicam, CP-14,304); salicylates (e.g., aspirin, disalcid, benorylate, trilisate, safapryn, solprin, diflunisal, fendosal); acetic acid derivatives (e.g., diclofenac, fenclofenac, indomethacin, sulindac, tolmetin, isoxepac, furofenac, tiopinac, zidometacin, acematacin, fentiazac, zomepirac, clindanac, oxepinac, felbinac, ketorolac); fenamates (e.g., mefenamic, meclofenamic, flufenamic, niflumic, tolf
  • COX-2 inhibitors are also suitable for use herein, and include, but are not limited to, AZD 3582 (Astrazeneca and NicOx), Celecoxib (Pharmacia Corp.) (4-[5-(4- methylphenyl)-3-(trifluoromethyl)-1 H-pyrazol-1 -yl] benzenesulfonamide), Meloxicam (Boehringer Ingelheim Pharmaceuticals) (4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1 ,2GW-406381 (Glaxosmithkline), Etoricoxib (Merck & Co.), Rofecoxib (MERCK & Co.) (4-[4-(methylsulfonyl) phenyl]-3- phenyl-2(5H)-furanone), Lumiracoxib (Novartis Pharma AG), Valdecoxib (Pharmacia Corp.) (4-(5-methyl- 3-phenyl-4-isox-azo
  • An anti-inflammatory agent also includes, without limitation, candelilla wax, bisabolol (e.g., a- bisabolol), aloe vera, plant sterols (e.g., phytosterol), Manjistha (extracted from plants in the genus Rubia, particularly Rubia Cordifolia), and Guggal (extracted from plants in the genus Commiphora, particularly Commiphora Mukul), kola extract, chamomile, red clover extract, sea whip extract, anise oil, garlic oil, ginger extract, vasoconstrictors such as phenylephrine hydrochloride, compounds of the Licorice (the plant Glycyrrhiza glabra) family, including glycyrrhetic acid, glycyrrhizic acid, and derivatives thereof (e.g., salts and esters).
  • candelilla wax e.g., candelilla wax
  • bisabolol e
  • Suitable salts of the foregoing compounds include metal and ammonium salts.
  • Suitable esters include C2-C24 saturated or unsaturated esters of the acids, preferably C10-C24, more preferably C16-C24.
  • Specific non-limiting examples of the foregoing include oil soluble licorice extract, the glycyrrhizic and glycyrrhetic acids themselves, mono ammonium glycyrrhizinate, monopotassium glycyrrhizinate, dipotassium glycyrrhizinate, ⁇ - ⁇ -glycyrrhetic acid, stearyl glycyrrhetinate, 3-stearyloxy-glycyrrhetinic acid, disodium 3-succinyloxy-p-glycyrrhetinate, and combinations thereof.
  • An anti-microbial agent includes, without limitation, antifungal, antibacterial, and antiseptic compounds.
  • Antifungal compounds include, but are not limited to, imidazole antifungals.
  • Specific antifungals include, without limitation, butocouazole nitrate, miconazole, econazole, ketoconazole, oxiconizole, haloprogin, clotrimazole, and butenafine HCI, naftifine, terbinafine, ciclopirox, and tolnaftate.
  • Antibacterials include, without limitation, an aminoglycoside, a tetracycline, a glycylcycline, a fluorocycline, an oxazolidinone, a peptidyl transferase (like an amphenicol and a pleuromutilin), a macrolide, a lincosamide, a streptogramin, a steroid antibacterial, a ⁇ -lactam (like a penicillin, a penem, a carbapenem, a cephem, a monobactam and a ⁇ -lactamase inhibitor), an antifolates (like a dihydrofolate reductase (DHFR) inhibitor, a sulphonamide, a topoisomerase inhibitor and a quinolone), an anaerobic DNA inhibitor (like a nitroimidazole derivative, a nitrofuran derivative and a rifamycin).
  • DHFR dihydrof
  • Antiseptics include, without limitation, an acridine compound (like ethacridine lactate, 9-Aminoacridine and euflavine), a biguanide compound, an amidine compound (like 1 ,8-Diazabicyco[5.4.0]Undec-7-ene (DBU), diminazene, and benzamidine, chlorhexidine, dibrompropamidine, propamidine and hexamidine), a phenol compound (like hexachlorophene, policresulen, phenol, triclosan, triclocarban, chloroxylenol, biphenylol and fenticlor), a nitrofuran compound (like nitrofurazone), an iodine compound (iodine/octylphenoxypolyglycolether, povidone-iodine, and diiodohydroxypropane), a quinoline compound (like dequalinium, chlorquinald
  • antibacterial and antiseptic compounds include, without limitation, butocouazole phenol- TEA complex, mupirocin, triclosan, chlorocresol, chlorbutol, iodine, clindamycin, CAE (Anjinomoto Co., Inc., containing DL-pyrrolidone carboxylic acid salt of L-Cocoyl Arginine Ethyl Ester), povidone-iodine, polyhexanide, polyhexamethylene biguanide, polymyxin b sulfate- bacitracin, zinc-neomycin sulfate- hydrocortisone, chloramphenicol, methylbenzethonium chloride, manuka honey and erythromycin and antiseptics (e.g., benzalkonium chloride, benzethonium chloride, chlorhexidine gluconate, mafenide acetate, nitrofurazone, nitromersol), antim
  • antimicrobial with antifungal actives include, without limitation, ⁇ -lactam drugs, quinolone drugs, 2,4,4'-trichloro-2'-hydroxy diphenyl ether, 3,4,4'-trichlorocarbanilide, amantadine, amantadine hydrochloride, amantadine sulfate, amikacin, amikacin sulfate, benzoic acid, butenafine, capreomycin, capreomycin sulfate, chlorhexidine, chlorhexidine gluconate, chlorhexidine hydrochloride, chlortetracycline, chlortetracycline hydrochloride, ciclopirox, ciprofloxacin, clindamycin hydrochloride, clotrimazole, doxycycline, doxycycline hydrochloride, econazole, efinaconazole, erythromycin, erythromycin estolate, ery
  • An antioxidant includes, without limitation, propyl, octyl and dodecyl esters of gallic acid, butylated hydroxyanisole (BHA, usually purchased as a mixture of ortho and meta isomers), butylated hydroxytoluene (BHT), nordihydroguaiaretic acid, Vitamin A, vitamin E, coenzyme Q-10, ascorbic acid and its salts, ascorbyl esters of fatty acids, ascorbic acid derivatives (e.g., magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl sorbate), tocopherol, tocopherol acetate, other esters of tocopherol, tocotrienols and their esters, and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (commercially available under the tradename TROLOX).
  • BHA butylated hydroxyanisole
  • BHT butylated hydroxytoluene
  • Vitamin A vitamin
  • antioxidants include uric acid and its salts and alkyl esters, sorbic acid and its salts, lipoic acid, amines (e.g., N,N-diethylhydroxylamine, amino-guanidine), sulfhydryl compounds (e.g., glutathione, N-acetyl cysteine), dihydroxy fumaric acid and its salts, lycine pidolate, arginine pilolate, nordihydroguaiaretic acid, bioflavonoids, curcumin, lysine, methionine, proline, superoxide dismutase, silymarin, tea extracts, grape skin/seed extracts, melanin, and rosemary extracts, and a cascading antioxidant, such as, e.g., EMBLICA (EMD Chemicals) and synovia.
  • EMBLICA EMD Chemicals
  • An anti-pruritic agent includes, without limitation, alclometasone dipropionate, betamethasone valerate, and isopropyl myristate MSD.
  • An anti-skin aging agent or anti-wrinkling agent includes, without limitation, a variety of agents, often in combination, that prevent or treat wrinkling through a variety of actions, including, without limitation, cosmetic products that contain hydroxy acids, retinol, retinoic, retinol palmitate, a derivative of vitamin A, (or its stronger, prescribed version Retin-A and Renova), bicyclic aromatic compounds with retinoid-type activity, including, without limitation, those described in EP 679 630.
  • An anti-skin aging agent or anti-wrinkling agent includes, without limitation, bicyclic aromatic compounds, compounds which have retinoid-type activity, free-radical scavengers, a hydroxy acid, a keto acid or derivatives thereof.
  • a "free-radical scavenger” includes, without limitation, a-tocopherol, superoxide dismutase, ubiquinol or certain metal-chelating agents.
  • a hydroxy acid includes, without limitation, a-hydroxy acids such as lactic acid and glycolic acid or ⁇ -hydroxy acids such as salicylic acid and salicylic acid derivatives such as the octanoyl derivative; other hydroxy acids and keto acids include, without limitation, malic, citric, mandelic, tartaric or glyceric acids or the salts, amides or esters thereof.
  • An anti-wrinkling agent and anti-skin aging agent include, without limitation, sulfur-containing D and L amino acids and their derivatives and salts, particularly the N-acetyl derivatives, a preferred example of which is N-acetyl-L-cysteine; thiols, e.g.
  • ethane thiol fat-soluble vitamins, ascorbyl palmitate, ceramides, pseudoceramides (e.g., pseudoceramides described in U.S. Patents 5,198,210; 4,778,823; 4,985,547; 5,175,321 , each of which is hereby incorporated by reference in its entirety), phospholipids (e.g., distearoyl lecithin phospholipid), fatty acids, fatty alcohols, cholesterol, plant sterols, phytic acid, lipoic acid; lysophosphatidic acid, and skin peel agents (e.g., phenol and the like), and mixtures thereof.
  • phospholipids e.g., distearoyl lecithin phospholipid
  • fatty acids e.g., distearoyl lecithin phospholipid
  • fatty acids e.g., distearoyl lecithin phospholipid
  • fatty acids e.g., distearoyl lecit
  • a fatty acid and/or fatty acid alcohol include, without limitation, straight or branched alkyl chains containing 12-20 carbon atoms and linoleic acid.
  • anti-wrinkle actives include, without limitation, those described in U.S. Pat. No. 6,217,888, which description is incorporated herein by reference.
  • An anti-viral agents includes, without limitation, acyclovir, peniciclovir, metal salts (e.g., silver nitrate, copper sulfate, iron chloride, etc.) and organic acids (e.g., malic acid, salicylic acid, succinic acid, benzoic acid, etc.).
  • compositions which contain additional suitable anti-viral agents include those described in copending U.S. patent application Ser. Nos. 09/421 ,084 (Beerse et al.); 09/421 ,131 (Biedermann et al.); 09/420,646 (Morgan et al.); and 09/421 ,179 (Page et al.), which were each filed on Oct. 19, 1999.
  • quencher actives are used for singlet and triplet excited electron stabilization caused from photons of energy and to reduce or eliminate degradation.
  • quencher actives include, without limitation, electron receptors, including, without limitation, polycrylene.
  • an infrared reflective coating comprises an agent that reflects infrared radiation, for instance, without limitation, at a wavelength between about 0.74 pm to about 300 ⁇ .
  • an infrared reflective coating includes, without limitation, coatings which produce different amounts of gloss and reflection.
  • a composition with an infrared reflective coating is used by a soldier, police, national guard, governmental agent, including, without limitation, an individual working for the Federal Bureau of Investigation, Alcohol, and Tobacco & Firearms, Secret Service, Central Intelligence Agency, Department of Justice or any other governmental agent, whether located in the United States or outside the United States or other individuals who requires an infrared reflective coating.
  • a deodorant includes, without limitation, aluminium bromohydrate, potassium alum, sodium aluminium chlorohydroxy lactate, aluminium sulfate, aluminium chlorohydrate, aluminium-zirconium tetrachlorohydrate, an aluminium-zirconium polychlorohydrate complexed with glycine, aluminium- zirconium trichlorohydrate, aluminium-zirconium octachlorohydrate, aluminium sesquichlorohydrate, aluminium sesquichlorohydrex PG, aluminium chlorohydrex PEG, aluminium zirconium octachlorohydrex glycine complex, aluminium zirconium pentachlorohydrex glycine complex, aluminium zirconium tetrachlorohydrex glycine complex, aluminium zirconium trichlorohydrex glycine complex, aluminium chlorohydrex PG, zirconium chlorohydrate, aluminium dichlorohydrate, aluminium dichlorohydrate, aluminiu
  • a deodorant also includes, without limitation, astringent salts and bioactive compounds.
  • An astringent salt includes, without limitation, organic and inorganic salts of aluminium, zirconium, zinc, and mixtures thereof.
  • Anions of the astringent salt include, without limitation, sulfate, chloride, chlorohydroxide, alum, formate, lactate, benzyl sulfonate or phenyl sulfonate.
  • An antiperspirant astringent salt includes, without limitation, aluminium halides, aluminium hydroxyhalides, zirconyl oxyhalides, zirconyl hydroxyhalides, and mixtures thereof.
  • An aluminium salt includes, without limitation, aluminium chloride and the aluminium hydroxyhalides having the general formula Al2(OH) x Q y XH20, wherein Q is chlorine, bromine or iodine; x is about 2 to about 5; x+y is about 6, wherein x and y are not necessarily integers; and X is about 1 to about 6.
  • a zirconium compound includes, without limitation, zirconium oxy salts and zirconium hydroxy salts, also referred to as zirconyl salts and zirconyl hydroxy salts, and represented by the general empirical formula ZrO(OH)22-nz L z , wherein z varies from about 0.9 to about 2 and is not necessarily an integer; n is the valence of L; 2-nz is greater than or equal to 0; and L is selected, without limitation, from the group consisting of halides, nitrate, sulfamate, sulfate, and mixtures thereof.
  • a deodorant also includes, without limitation, a bacteriostatic quaternary ammonium compound, such as, e.g., cetyl trimethyl ammonium bromide, cetyl pyridinium chloride, benzethonium chloride, diisobutylbenzoxyethoxyethyldimethylbenzyl ammonium chloride, sodium N-lauryl sarcosine, sodium N- polymethyl sarcosine, lauroyl sarcosine, N-myristolyl glycine, potassium N-lauroyl sarcosine, and stearyl trimethyl ammonium chloride; or a bioactive compound; or a carbonate or bicarbonate salt, such as, for example, the alkali metal carbonates and bicarbonates, and the ammonium and tetralkylammonium carbonates and bicarbonates.
  • a bacteriostatic quaternary ammonium compound such as, e.g., cetyl tri
  • a hair bleaching agent includes, without limitation, a perborate salt or a persulfate salt.
  • a hair growth inhibiting includes, without limitation, serine proteases such as trypsin; vitamins such as a- tocophenol (vitamin E) and derivatives thereof such as tocophenol acetate and tocophenol palmitate; antineoplastic agents, such as doxorubicin, cyclophosphamide, chlormethine, methotrexate, fluorouracil, vincristine, daunorubicin, bleomycin and hydroxycarbamide; anticoagulants, such as heparin, heparinoids, coumaerins, detran and indandiones; antithyroid drugs, such as iodine, thiouracils and carbimazole; lithium and lithium carbonate; interferons, such as interferon a, interferon a-2a and interferon a-2b; retinoids, such as retinol (vitamin
  • Preferred hair growth inhibitory agents include serine proteases, retinol, isotretinoin, betamethoisone, a- tocophenol and derivatives thereof, or mixtures thereof.
  • An anti-lice agent includes, without limitation, include organochlorines, such as, e.g., lindane, organophosphates, such as, e.g., malathion, carbamates, such as, e.g., carbaryl, pyrethrins, such as, e.g.
  • pyrethrum such as, e.g., permethrin, phenothrin, bioallethrin, and spinosad, such as, e.g. , spinosyn A and spinosyn D, bactrim, benzyl alcohol, crotamiton, dimeticone and ivermectin.
  • pyrethrum such as, e.g., permethrin, phenothrin, bioallethrin
  • spinosad such as, e.g. , spinosyn A and spinosyn D, bactrim, benzyl alcohol, crotamiton, dimeticone and ivermectin.
  • a fragrance includes, without limitation, alcohols (e.g., furaneol, 1 - hexanol, cis-3-hexen-l-ol, menthol, or the like); aldehydes (e.g., acetaldehyde, hexanal, cis-3-hexenal, furfural, or the like); esters (e.g., fructone, hexyl acetate, ethyl methylphenylglycidate, methyl formate, methyl acetate, methyl butyrate, methyl butanoate, ethyl acetate, ethyl butyrate, ethyl butanoate, isoamyl acetate, pentyl butyrate, pentyl butanoate, pentyl pentanoate, benzoin, black, cajuput oil, caraway, carrot seed, coriander, cypress, dill, f
  • fragrance molecules are geraniol, geranyl acetate, linalool, linalyl acetate, tetrahydrolinalool, citronellol, citronellyl acetate, dihydromyrcenol, dihydromyrcenyl acetate, tetrahydromyrcenol, terpineol, terpinyl acetate, nopol, nopyl acetate, 2-phenylethanol, 2-phenylethyl acetate, benzyl alcohol, benzyl acetate, benzyl salicylate, benzyl benzoate, styrallyl acetate, amyl salicylate, dimethylbenzyl carbinol, trichloromethylphenylcarbinyl acetate, p-tert-butyl-cyclohexyl acetate, isononyl acetate, vetiveryl acetate,
  • Exemplary fragrant molecules include bergamot oil, coriander oil, dimethyl heptanol, dimethyl benzyl carbinyl acetate, geranyl acetate, citronellyl acetate, rose synthetic, geranium bourbon, hedione, iso eugenol, methyl eugenol styrallyl acetate, stemone, rose oxide laevo, aldehyde C-ll undecyclic, derivatives of 2,6- dimethyl-2-alkoxy octan-7-ol, vertivert oil, vetiverol, vetiveryl, acetate, quaiac wood oil, esters ol- anthranilic acid, benzyl salicylate, benzyl benzoate, oak moss, eugenol, p-tert-butyl cyclohexyl acetate and coumarin.
  • a colorant includes, without limitation, an agent used to color skin, nail, hair or another surface.
  • a colorant includes, without limitation, aluminum powder, annatto, bismuth citrate, bismuth oxychloride, bronze powder, caramel, carmine, ⁇ -carotene, chromium hydroxide green, chromium oxide green, copper powder, dihydroxyacetone, disodium EDTA-copper, ferric ammonium, ferrocyanide, ferric ferrocyanide, guaiazulene, guanine, henna, iron oxide, lead acetate, luminescent zinc sulfide, manganese violet, mica, potassium sodium copper chlorophyllin (chlorophyllin-copper complex), pyrophyllite, silver, titanium dioxide, ultramarine, zinc oxide, D&C Black No.
  • D&C Black No. 3 FD&C Blue No. 1 , D&C Blue No. 4, D&C Brown No. 1 , FD&C Green No. 3, D&C Green No. 5, D&C Green No. 6, D&C Green No. 8, D&C Orange No. 4, D&C Orange No. 5, D&C Orange No. 10, D&C Orange No. 1 1 , FD&C Red No. 4, D&C Red No. 6, D&C Red No. 7, D&C Red No. 17, D&C Red No. 21 , D&C Red No. 22, D&C Red No. 27, D&C Red No. 28, D&C Red No. 30, D&C Red No. 31 , D&C Red No. 33, D&C Red No. 34, D&C Red No.
  • a camouflage agent includes, without limitation, a UV reflector, a UV absorber, an infrared (IR) reflector and an IR absorber.
  • a UV reflector reflects wavelengths from about 10 nm to about 400 nm.
  • An UV absorber aborbs wavelengths from about 10 nm to about 400 nm.
  • Non-limiting examples of a UV absorber include an acrylate dye, a benzotriazole dye, a benzophenone dye and a phosphite dye.
  • UV absorber compounds include, without limitation, 2,4-dihydroxy benzophenone, 2,4- dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'- dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-dodecyloxybenzophenone, 2-hydroxy-4-octyloxybenzophenone, 2-hydroxy-4-methoxybenzophenone, ethyl-2-cyano-3,3- diphenylacrylate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, 2-hydroxy-4-methyoxy-benzophenone-5-sulfonic acid, 2,2'-dihydroxy-4,4'dimethoxy-5- sulfobenzophenone, 2-(2-hydroxy-5-methyl-phenyl)-2H-
  • An IR reflector reflects wavelengths from about 700 nm to about 1500 nm.
  • Non-limiting examples of an IR refelctor include a metal oxide.
  • Specific IR reflector compounds include, without limitation, an iron oxide, a titanium dioxide and a zinc oxide.
  • An IR absorber aborbs wavelengths from about 700 nm to about 1500 nm.
  • Non-limiting examples of an IR absorber include an azo dye, a croconium dye, a diphenylmethane dye, a heptamethinecyanine dye, a metal complex dye, a naphthalocyanine dye, a photchromic dye, a phthalocynine dye, a polymethine dye, a pyrylium dye, a quinone dye, a squarylium dye and a triphenylmethane dye.
  • a metal complex dye includes, without limitation, a dithiolene metal complex, an indoanilinetype metal complex and a phenylenediamine metal complex.
  • Specific IR absorber compounds include, without limitation, 2-[2-[2-Chloro-3-[(1 ,3-dihydro-1 ,3,3-trimethyl-2H-indol-2-ylidene)ethylidene]-1 - cycloxen-1 -yl]-ethenyl]-1 ,3,3-trimethyl-1 H indolium iodide, 2-[2-[2-Chloro-3-[(1 ,3-dihydro-1 ,3,3-trimethyl- 2H-indol-2-ylidene)ethylidene]-1 -cycloxen-1 -yl]-ethenyl]-1 ,3,3-trimethyl-1 H indolium perchlorate, 2-[2-[2-[2- Chloro-3-[(1 ,3-d
  • a soothing agent can be a cooling agent or a heating agent.
  • Soothing agents include, without limitation, herb extracts, such as, e.g. , aloe vera, a-bisabolol, D-panthenol, allantoin, hamamelis, chamomile, yarrow; calendula, comfrey, witch hazel and other astringents, sea weed, and oat extracts; oils, selected from the group consisting of: almond oil, avocado oil, and comfrey; and essential oils, selected from the group consisting of: cardamone, eucalyptus, mentha piperita (peppermint), hyssop, and rosemary; waxy or unctuous substances selected from the group consisting of: lanolin or petroleum jelly, minerals, selected from the group consisting of: zinc oxide, calamine and selenium; vitamins, selected from the group consisting of: tocopheryl acetate (vitamin E), and pharmaceutical
  • a cooling agent includes, without limitation, menthol; an isomer of menthol, a menthol derivative (e.g., menthol ethylene glycol carbonate, which is now known as Frescolat® type MGC, menthol Propylene Glycol Carbonate (Frescolat® type MPC), menthyl lactate (Frescolat ML®) and Menthone Glycerin Acetal (Frescolat MGA®) and 3-(l-Menthoxy)-1 ,2-propanediol); 4-Methyl-3-(1 -pyrrolidinyl)-2[5H]- furanone; WS-23, lcilin, lcilin Unilever Analog, 5-methyl-4-(1 -pyrrolidinyl)-3-[2H]-furanone; 4,5-dimethyl-3- (1 -pyrrolidinyl)-2[5H]-furanone; isopulegol, 3-(l-menth
  • a heating agent includes, without limitation, polyhydric alcohols, capsicum (red pepper) powder, a capsicum tincture, capsicum extract, capsaicin, homocapsaicin, homodihydrocapsaicin, nonanoyl vanillyl amide, nonanoic acid vanillyl ether, vanillyl alcohol alkyl ether derivatives, such as vanillyl ethyl ether, vanillyl butyl ether, vanillyl pentyl ether, and vanillyl hexyl ether, isovanillyl alcohol alkyl ethers, ethylvanillyl alcohol alkyl ethers, veratryl alcohol derivatives, substituted benzyl alcohol derivatives, substituted benzyl alcohol alkyl ethers, vanillin propylene glycol acetal, ethylvanillin propylene glycol acetal, ginger extract, ginger oil, gingeol, and gingeron.
  • a jellyfish repellent agent is used for repelling or preventing stings from memebers of the phylum Cnidaria (e.g., jellyfish, sea anemone, and coral), the phylum Myxozoa, or the like).
  • a jellyfish repellent agent includes, without limitation, one or both of an antihistamine agent and one or more cations.
  • An antihistamine agent includes, without limitation, diphenhydramine, cimetidine or tripelennamine or other histamine binding inhibitors.
  • a jellyfish repellent agent is present in a concentration from about 0.0005% to about 2.0% or from about 0.001 % to about 0.2%, or similar effective amount ).
  • a cation includes, without limitation, metal cations and alkali cations such as, e.g., Ca ++ , K + , Na + , Mn ++ , Co ++ , Mg ++ , or Fe ++ , or other substance which is capable of supplying positively charged ions.
  • a cation is present in a concentration of from about 5 mM to about 1 M, or about 25 mM to about 500 mM, or from about 50 mM to about 200 mM.
  • a skin whitening agent includes, without limitation, skin lightening agent and skin bleaching agent.
  • a skin whitening agent include, without limitation, a-hydroxyl acids ("AHA's”), arbutin, cinnamomum subavenium, EMBLICA (also an antioxidant), hydroquinone, kojic acid, azelaic acid, ascorbic acid and derivatives thereof (e.g., magnesium ascorbyl phosphate or sodium ascorbyl phosphate), niacinamide, a licorice extract (e.g., glabridin), a mulberry extract and a placental extract.
  • a skin whitening agent can include a depigmentation agent including, without limitation, monobenzone or mequinol. Additional skin whitening agents are also described in WO 1995/34280, WO 1995/07432, and WO 1995/23780.
  • a sunless tanning agent includes, without limitation, dihydroxyacetone (DHA); glyceryl aldehyde; tyrosine and tyrosine derivatives such as, e.g., malyltyrosine, tyrosine glucosinate, and ethyl tyrosine; phospho-DOPA, indoles and derivatives thereof.
  • DHA dihydroxyacetone
  • glyceryl aldehyde such as, e.g., malyltyrosine, tyrosine glucosinate, and ethyl tyrosine
  • phospho-DOPA indoles and derivatives thereof.
  • a vitamin includes, without limitation, Vitamin A and derivatives thereof (including, for example, retinol), ascorbic acid (Vitamin C and derivatives), Vitamin B (e.g., riboflavin, vitamin B2), biotin, Vitamin D (all forms), Vitamin E and derivatives thereof such as tocopheryl acetate, ⁇ -carotene, panthothenic acid and more.
  • Vitamin A and derivatives thereof including, for example, retinol), ascorbic acid (Vitamin C and derivatives), Vitamin B (e.g., riboflavin, vitamin B2), biotin, Vitamin D (all forms), Vitamin E and derivatives thereof such as tocopheryl acetate, ⁇ -carotene, panthothenic acid and more.
  • a skin care agent includes, without limitation, those found in the CTFA Cosmetic Ingredient Handbook, Seventh Edition, 1997 and the Eighth Edition, 2000 and Remington's Pharmaceutical Sciences, 20th Ed., Lippincott Williams & Witkins, Baltimore, Md. (2000) (hereinafter Remington's), U.S. Pharmacopeia and National Formulary, The United States Pharmacopeia Convention, Inc., Rockville, Md. and Physician's Desk Reference, Medical Economics Co., Inc., Oradell, N.J. all of which are incorporated herein by reference.
  • a chelating agent is a compound that chelates or binds metallic ions, such as with a heterocyclic ring structure so that the ion is held by chemical bonds from each of the participating rings.
  • Chelating agent includes, without limitation, ethylene diaminetetraacetic acid (EDTA), EDTA disodium, calcium disodium edetate, EDTA trisodium, EDTA tetrasodium and EDTA dipotassium.
  • a preservative includes, without limitation, citric acid, tartaric acid, phosphoric acid, iminodiacetic acid, nitrilotriacetic acid, hydroxyethyleneaminodiacetic acid and ethylenediaminetetraacetic acid and salts thereof; para-hydroxybenzoates such as butyl paraben, methyl paraben and propyl paraben; imidazolines (e.g., imidiazolinylurea), triclosan, hydantoins (e.g., dimethyloldimethylhydantoin), isothiazolidinone compounds and mixtures thereof, KATHON ® CG and KATHON ® CGII, which contain methylchloroisothiazolinone and methylisothiazolinone (Rohm and Haas).
  • a sunscreen additional or active agent is an ultraviolet (UV) ray-blocking compound that absorbs, blocks and/or reflects UV radiation.
  • a sunscreen active agent disclosed herein absorbs, blocks and/or reflects UV radiation given off by a natural source, such as, e.g., sunlight, and/or man-made source, such as, e.g., a fluorescent light bulb.
  • a sunscreen active agent exhibits absorptive and/or reflective properties within the wavelength region of between about 290 to about 420 nm. Any sunscreen active agent known in the art or apparent to a skilled artisan may be used.
  • a sunscreen active agent disclosed herein may be an organic molecule or inorganic molecule.
  • a sunscreen active agent may be a UVA absorber, a UVA blocker, a UVA reflector, a UVB absorber, a UVB blocker, a UVB reflector, a broad-spectrum UVA and UVB absorber, a broad-spectrum UVA and UVB blocker, a broad-spectrum UVA and UVB reflector, a physical blocker, a physical reflector, or any combination thereof.
  • a UVA absorber can be a UVA I absorber and/or UVA II absorber.
  • Sunscreen additional or active agents commonly contain one or more of the following ingredients:
  • a chemical sunscreen active agent typically an organic compound that absorb UV light
  • a physical sunscreen active agent typically an inorganic particulates that reflect, scatter, and absorb UV light
  • a hybrid sunscreen active agent typically an organic particulate that absorbs UV light like an organic chemical compound, but also contain multiple chromophores that may reflect and scatter UV light like an inorganic particulate.
  • Organic sunscreen additional or active agents can be grouped based upon their chemical structure. Such groups include, without limitation: 1) a para-amino benzoate or derivative or salt thereof;
  • a sunscreen additional or active agent can be a UVA sunscreen active agent, a UVB sunscreen active agent, or a UVA/UVB or "broad-spectrum" sunscreen active agent.
  • a UVA sunscreen active agent exhibits absorptive, blocking and/or reflective properties within the wavelength region of between about 290 nm to about 320 nm.
  • a UVA sunscreen active agent exhibits absorptive, blocking and/or reflective properties within the wavelength region of between about 320 nm to about 420 nm.
  • a broad-spectrum UVA/UVB sunscreen active agent exhibits absorptive, blocking and/or reflective properties within the wavelength region of between about 290 to about 420 nm.
  • Non-limiting examples of a UVA sunscreen active agent include Avobenzone (butyl methoxydibenzoylmethane or Parsol 1789), bisdisulizole disodium (Neo Heliopan AP), diethylamino hydroxybenzoyl hexyl benzoate (Uvinul A Plus), ecamsule (Mexoryl SX) and menthyl anthranilate.
  • Non-limiting examples of a UVB sunscreen active agent include amiloxate, 4-aminobenzoic acid (PABA), cinoxate, ethylhexyl triazone (Uvinul T 150), homosalate, 4- methylbenzylidene camphor (Parsol 5000), octyl methoxycinnamate (Octinoxate), octyl salicylate (Octisalate), Padimate O (Escalol 507), phenylbenzimidazole sulfonic acid (Ensulizole), polysilicone-15 (Parsol SLX) and trolamine salicylate.
  • PABA 4-aminobenzoic acid
  • cinoxate ethylhexyl triazone
  • Hosalate 4- methylbenzylidene camphor
  • Octinoxate octyl methoxycinnamate
  • Octyl salicylate Octisalate
  • Non-limiting examples of a broad-spectrum UVA/UVB sunscreen active agent include bemotrizinol (Tinosorb S), benzophenones 1 -12, dioxybenzone, drometrizole trisiloxane (Mexoryl XL), Iscotrizinol (Uvasorb HEB), octocrylene, oxybenzone (Eusolex 4360), sulisobenzone, bisoctrizole (Tinosorb M), titanium dioxide, and zinc oxide.
  • a sunscreen additional or active agent useful for a composition disclosed herein are also described in, e.g., U.S. Patents 5,169,624; 5,543,136; 5,849,273; 5,904,917; 6,224,852; 6,217,852; and Segarin et al., chapter Vil, pages 189 of Cosmetics Science and Technology, and Final Over-the-Counter Drug Products Monograph on Sunscreens (Federal Register, 1999:64:27666 27963), each of which are incorporated herein by reference in its entirety.
  • a thickening agent (or gallant) is used to adjust the texture and viscosity of a composition disclosed herein.
  • a thickening agent includes, without limitation, CARBOPOLTM resins [e.g., 934, 971 , 974, 980, 981 ] and PEMULENTM [TR-1 and TR-2] [both CARBOPOLTM and PEMULENTM are registered trademarks of BF Goodrich], Noveon AA-1 , ETD resins, and ULTREZTM resins or carbomers.
  • a medicinal agent includes, without limitation, camphor, menthol, benzocaine, butamben picrate, dibucaine, dibucaine hydrochloride, dimethisoquin hydrochloride, dyclonine hydrochloride, lidocaine, metacresol, lidocaine hydrochloride, pramoxine hydrochloride, tetracaine, tetracaine hydrochloride, benzyl alcohol, camphorated metacresol, juniper tar, phenol, phenolate sodium, resorcinol, diphenhydramine hydrochloride, tripelennamine hydrochloride, hydrocortisone, a corticosteroid, and hydrocortisone acetate, burn relief agents, such as o-amino-p-toluenesulfonamide monoacetate; dermatitis relief agents, such as the active steroid amcinonide, diflorasone diacetate, and hydrocortisone;
  • Other medicinal agents include, without limitation, ones for treating dermatological conditions such as psoriasis, acne, eczema, and other skin conditions due to disease, pathology, accident, as well as medicinal agents useful in the treatment of exposure to poison oak, poison ivy, poison sumac, and the like.
  • additional ingredients can be present include, without limitation, a fragrance, a dye, an oil, a non-polar wax, a liquid hydrocarbon and/or an antimicrobial material.
  • a non-polar wax includes, without limitation, ester waxes, diester waxes, hydrocarbon waxes, silicone waxes and triglyceride waxes and mixtures thereof.
  • An antimicrobial material includes, without limitation, triclocarban, triclosan, iodophors, iodine formulations, phenolic compounds, e.g. hexachlorophene, and bisbiguanides, e.g. chlorhexidene gluconate, and the like. See, e.g.
  • a composition disclosed herein may comprise, e.g., at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, at least nine or at least ten additional agents.
  • a composition disclosed herein may comprise, e.g., at most one, at most two, at most three, at most four, at most five, at most six, at most seven, at most eight, at most nine or at most ten additional agents.
  • a composition disclosed herein may comprise, e.g., about 1 to about 2, about 1 to about 3, about 1 to about 4, about 1 to about 5, about 1 to about 6, about 1 to about 7, about 1 to about 8, about 1 to about 9, about 1 to about 10, about 2 to about 3, about 2 to about 4, about 2 to about 5, about 2 to about 6, about 2 to about 7, about 2 to about 8, about 2 to about 9, about 2 to about 10, about 3 to about 4, about 3 to about 5, about 3 to about 6, about 3 to about 7, about 3 to about 8, about 3 to about 9, about 3 to about 10, about 4 to about 5, about 4 to about 6, about 4 to about 7, about 4 to about 8, about 4 to about 9, about 4 to about 10, about 5 to about 6, about 5 to about 7, about 5 to about 8, about 5 to about 9, about 5 to about 10, about 6 to about 7, about 6 to about 8, about 6 to about 9, about 6 to about 10, about 7 to about 8, about 7 to about 9, about 7 to about 10, about 8 to about 9, about 8 to about 10 or about 9 to about 10 additional agents.
  • a composition disclosed herein comprises an additional agent in an amount sufficient to promote or facilitate the function or activity of that additional agent.
  • the amount of additional agent can range from 0.00% to 99.9% by total weight of the composition, or any integer or range in between.
  • a composition disclosed herein comprises an additional agent in an amount of, e.g., at least 0.1 %, at least 0.2%, at least 0.3%, at least 0.4%, at least 0.5%, at least 0.6%, at least 0.7%, at least 0.8%, at least 0.9%, at least 1 .0%, at least 2.0%, at least 3.0%, at least 4.0%, at least 5.0%, at least 6.0%, at least 7.0%, at least 8.0%, at least 9.0%, at least 10%, at least 1 1 %, at least 12%, at least 13%, at least 14%, at least 15%, at least 20%, at least 25% of the total weight of the composition.
  • a composition disclosed herein comprises an additional agent in an amount of, e.g., at most 0.1 %, at most 0.2%, at most 0.3%, at most 0.4%, at most 0.5%, at most 0.6%, at most 0.7%, at most 0.8%, at most 0.9%, at most 1 .0%, at most 2.0%, at most 3.0%, at most 4.0%, at most 5.0%, at most 6.0%, at most 7.0%, at most 8.0%, at most 9.0%, at most 10%, at most 1 1 %, at most 12%, at most 13%, at most 14%, at most 15%, at most 20%, at most 25% of the total weight of the composition.
  • a composition disclosed herein comprises an additional agent in an amount of, e.g., about 0.1 % to about 0.5%, about 0.1 % to about 1 .0%, about 0.1 % to about 2.0%, about 0.1 % to about 3.0%, about 0.1 % to about 4.0%, about 0.1 % to about 5.0%, about 0.1 % to about 6.0%, about 0.1 % to about 7.0%, about 0.1 % to about 8.0%, about 0.1 % to about 9.0%, about 0.1 % to about 10%, about 0.5% to about 1 .0%, about 0.5% to about 2.0%, about 0.5% to about 3.0%, about 0.5% to about 4.0%, about 0.5% to about 5.0%, about 0.5% to about 6.0%, about 0.5% to about 7.0%, about 0.5% to about 8.0%, about 0.5% to about 9.0%, about 0.5% to about 10%, about 1 .0% to about 2.0%, about 1 .0% to about 3.0%, about 1.0% to about 4.0%, about 1
  • an agent disclosed herein can have more than one function.
  • inorganic blockers such as Tioveil and Spectraveil (both of the Tioxide Group) can act as film-formers and have other advantageous uses.
  • a composition includes, without limitation, a wide variety of additional components selected so as to avoid any undesirable reaction with the primary components of the composition.
  • CTFA Cosmetic Ingredient Handbook, Seventh Edition, 1997 and the Eighth Edition, 2000 (incorporated by reference herein), provide a broad source of possible cosmetic and pharmaceutical ingredients typically used in skin care compositions.
  • additional components include, without limitation, one or more of the following: Absorbents, abrasives, anticaking agents, antifoaming agents, binders, biological additives, buffering agents, bulking agents, chelating agents/sequestrants (e.g., disodium EDTA), chemical additives, colorants, cosmetic astringents, cosmetic biocides, denaturants, drug astringents, emollients (including glycerin alovera, and Vitamins A, C, and D [hydrating agents and skin protectants]), foam boosters, fragrance components, gums, humectants (including urea, guanidine, glycolic acid, polyhydroxy alcohols such as sorbitol, glycerin, hexanetriol, propylene glycol, hexylene glycol and the like, polyethylene glycol, sugars and starches, sugar and starch derivatives, D-panthenol, hyaluronic acid, lact
  • a composition disclosed herein comprises a capsule disclosed herein in an amount sufficient to provide an effective amount of the one or more active agents and/or an additional agent disclosed herein.
  • a composition disclosed herein comprises a capsule disclosed herein in an amount of, e.g., at least 0.1 %, at least 0.2%, at least 0.3%, at least 0.4%, at least 0.5%, at least 0.6%, at least 0.7%, at least 0.8%, at least 0.9%, at least 1 .0%, at least 2.0%, at least 3.0%, at least 4.0%, at least 5.0%, at least 6.0%, at least 7.0%, at least 8.0%, at least 9.0%, at least 10%, at least 11 %, at least 12%, at least 13%, at least 14%, at least 15%, at least 16%, at least 17%, at least 18%, at least 19%, at least 20%, at least 21 %, at least 22%, at least 23%, at least 24%, at least 25%, at least 26%, at least 27%, at least
  • a composition disclosed herein comprises a capsule disclosed herein in an amount of, e.g., at most 0.1 %, at most 0.2%, at most 0.3%, at most 0.4%, at most 0.5%, at most 0.6%, at most 0.7%, at most 0.8%, at most 0.9%, at most 1 .0%, at most 2.0%, at most 3.0%, at most 4.0%, at most 5.0%, at most 6.0%, at most 7.0%, at most 8.0%, at most 9.0%, at most 10%, at most 1 1 %, at most 12%, at most 13%, at most 14%, at most 15%, at most 16%, at most 17%, at most 18%, at most 19%, at most 20%, at most 21 %, at most 22%, at most 23%, at most 24%, at most 25%, at most 26%, at most 27%, at most 28%, at most 29%, at most 30%, at most 31 %, at most 32%, at most 33%, at most 34% or at most
  • a composition disclosed herein comprises a capsule disclosed herein in an amount of, e.g., about 0.1 % to about 0.5%, about 0.1 % to about 1.0%, about 0.1 % to about 2.0%, about 0.1 % to about 3.0%, about 0.1 % to about 4.0%, about 0.1 % to about 5.0%, about 0.1 % to about 6.0%, about 0.1 % to about 7.0%, about 0.1 % to about 8.0%, about 0.1 % to about 9.0%, about 0.1 % to about 10%, about 0.1 % to about 15%, about 0.1 % to about 20%, about 0.1 % to about 25%, about 0.1 % to about 30%, about 0.1 % to about 35%, about 0.1 % to about 40%, about 0.5% to about 1 .0%, about 0.5% to about 2.0%, about 0.5% to about 3.0%, about 0.5% to about 4.0%, about 0.5% to about 5.0%, about 0.5% to about 6.0%, about 0.5% to about 7.
  • a composition disclosed herein comprises a capsule disclosed herein in an amount of, e.g., about 5.0% to about 6.0%, about 5.0% to about 7.0%, about 5.0% to about 8.0%, about 5.0% to about 9.0%, about 5.0% to about 10%, about 5.0% to about 1 1 %, about 5.0% to about 12%, about 5.0% to about 13%, about 5.0% to about 14%, about 5.0% to about 15%, about 5.0% to about 16%, about 5.0% to about 17%, about 5.0% to about 18%, about 5.0% to about 19%, about 5.0% to about 20%, about 5.0% to about 25%, about 5.0% to about 30%, about 5.0% to about 35%, about 5.0% to about 40%, about 8.0% to about 9.0%, about 8.0% to about 10%, about 8.0% to about 1 1 %, about 8.0% to about 12%, about 8.0% to about 13%, about 8.0% to about 14%, about 8.0% to about 15%, about 8.0% to about 16%, about 8.0% to about 17%,
  • a composition disclosed herein comprises a cellulose derived capsule in an amount sufficient to provide an effective amount of the one or more active agents and/or an additional agent disclosed herein.
  • a composition disclosed herein comprises a cellulose derived capsule in an amount of, e.g., at least 0.1 %, at least 0.2%, at least 0.3%, at least 0.4%, at least 0.5%, at least 0.6%, at least 0.7%, at least 0.8%, at least 0.9%, at least 1 .0%, at least 2.0%, at least 3.0%, at least 4.0%, at least 5.0%, at least 6.0%, at least 7.0%, at least 8.0%, at least 9.0%, at least 10%, at least 11 %, at least 12%, at least 13%, at least 14%, at least 15%, at least 16%, at least 17%, at least 18%, at least 19%, at least 20%, at least 21 %, at least 22%, at least 23%, at least 24%, at least 25%, at least 26%, at least 27%
  • a composition disclosed herein comprises a cellulose derived capsule in an amount of, e.g., at most 0.1 %, at most 0.2%, at most 0.3%, at most 0.4%, at most 0.5%, at most 0.6%, at most 0.7%, at most 0.8%, at most 0.9%, at most 1 .0%, at most 2.0%, at most 3.0%, at most 4.0%, at most 5.0%, at most 6.0%, at most 7.0%, at most 8.0%, at most 9.0%, at most 10%, at most 1 1 %, at most 12%, at most 13%, at most 14%, at most 15%, at most 16%, at most 17%, at most 18%, at most 19%, at most 20%, at most 21 %, at most 22%, at most 23%, at most 24%, at most 25%, at most 26%, at most 27%, at most 28%, at most 29%, at most 30%, at most 31 %, at most 32%, at most 33%, at most 34% or at most
  • a composition disclosed herein comprises a cellulose derived capsule in an amount of, e.g., about 0.1 % to about 0.5%, about 0.1 % to about 1 .0%, about 0.1 % to about 2.0%, about 0.1 % to about 3.0%, about 0.1 % to about 4.0%, about 0.1 % to about 5.0%, about 0.1 % to about 6.0%, about 0.1 % to about 7.0%, about 0.1 % to about 8.0%, about 0.1 % to about 9.0%, about 0.1 % to about 10%, about 0.1 % to about 15%, about 0.1 % to about 20%, about 0.1 % to about 25%, about 0.1 % to about 30%, about 0.1 % to about 35%, about 0.1 % to about 40%, about 0.5% to about 1 .0%, about 0.5% to about 2.0%, about 0.5% to about 3.0%, about 0.5% to about 4.0%, about 0.5% to about 5.0%, about 0.5% to about 6.0%, about 0.5%
  • a composition disclosed herein comprises a cellulose derived capsule in an amount of, e.g., about 5.0% to about 6.0%, about 5.0% to about 7.0%, about 5.0% to about 8.0%, about 5.0% to about 9.0%, about 5.0% to about 10%, about 5.0% to about 1 1 %, about 5.0% to about 12%, about 5.0% to about 13%, about 5.0% to about 14%, about 5.0% to about 15%, about 5.0% to about 16%, about 5.0% to about 17%, about 5.0% to about 18%, about 5.0% to about 19%, about 5.0% to about 20%, about 5.0% to about 25%, about 5.0% to about 30%, about 5.0% to about 35%, about 5.0% to about 40%, about 8.0% to about 9.0%, about 8.0% to about 10%, about 8.0% to about 1 1 %, about 8.0% to about 12%, about 8.0% to about 13%, about 8.0% to about 14%, about 8.0% to about 15%, about 8.0% to about 16%, about 8.0% to about 17%
  • a composition disclosed herein comprises a sol-gel capsule in an amount sufficient to provide an effective amount of the one or more active agents and/or an additional agent disclosed herein.
  • a composition disclosed herein comprises a cellulose derived capsule in an amount of, e.g., at least 0.1 %, at least 0.2%, at least 0.3%, at least 0.4%, at least 0.5%, at least 0.6%, at least 0.7%, at least 0.8%, at least 0.9%, at least 1 .0%, at least 2.0%, at least 3.0%, at least 4.0%, at least 5.0%, at least 6.0%, at least 7.0%, at least 8.0%, at least 9.0%, at least 10%, at least 1 1 %, at least 12%, at least 13%, at least 14%, at least 15%, at least 16%, at least 17%, at least 18%, at least 19%, at least 20%, at least 21 %, at least 22%, at least 23%, at least 24%, at least 25%, at least 26%, at least 27%
  • a composition disclosed herein comprises a sol-gel capsule in an amount of, e.g. , at most 0.1 %, at most 0.2%, at most 0.3%, at most 0.4%, at most 0.5%, at most 0.6%, at most 0.7%, at most 0.8%, at most 0.9%, at most 1 .0%, at most 2.0%, at most 3.0%, at most 4.0%, at most 5.0%, at most 6.0%, at most 7.0%, at most 8.0%, at most 9.0%, at most 10%, at most 11 %, at most 12%, at most 13%, at most 14%, at most 15%, at most 16%, at most 17%, at most 18%, at most 19%, at most 20%, at most 21 %, at most 22%, at most 23%, at most 24%, at most 25%, at most 26%, at most 27%, at most 28%, at most 29%, at most 30%, at most 31 %, at most 32%, at most 33%, at most 34% or at most
  • a composition disclosed herein comprises a sol-gel capsule in an amount of, e.g. , about 0.1 % to about 0.5%, about 0.1 % to about 1 .0%, about 0.1 % to about 2.0%, about 0.1 % to about 3.0%, about 0.1 % to about 4.0%, about 0.1 % to about 5.0%, about 0.1 % to about 6.0%, about 0.1 % to about 7.0%, about 0.1 % to about 8.0%, about 0.1 % to about 9.0%, about 0.1 % to about 10%, about 0.1 % to about 15%, about 0.1 % to about 20%, about 0.1 % to about 25%, about 0.1 % to about 30%, about 0.1 % to about 35%, about 0.1 % to about 40%, about 0.5% to about 1 .0%, about 0.5% to about 2.0%, about 0.5% to about 3.0%, about 0.5% to about 4.0%, about 0.5% to about 5.0%, about 0.5% to about 6.0%, about 0.5%
  • a composition disclosed herein comprises a sol-gel capsule in an amount of, e.g. , about 5.0% to about 6.0%, about 5.0% to about 7.0%, about 5.0% to about 8.0%, about 5.0% to about 9.0%, about 5.0% to about 10%, about 5.0% to about 11 %, about 5.0% to about 12%, about 5.0% to about 13%, about 5.0% to about 14%, about 5.0% to about 15%, about 5.0% to about 16%, about 5.0% to about 17%, about 5.0% to about 18%, about 5.0% to about 19%, about 5.0% to about 20%, about 5.0% to about 25%, about 5.0% to about 30%, about 5.0% to about 35%, about 5.0% to about 40%, about 8.0% to about 9.0%, about 8.0% to about 10%, about 8.0% to about 1 1 %, about 8.0% to about 12%, about 8.0% to about 13%, about 8.0% to about 14%, about 8.0% to about 15%, about 8.0% to about 16%, about 8.0% to about 17%,
  • a composition disclosed herein generally has a pH of about 4 to about 8.
  • a composition has a pH of, e.g., about 4 to about 5, about 4 to about 6, about 4 to about 7, about 4 to about 8, about 5 to about 6, about 5 to about 7, about 5 to about 8, about 6 to about 7, about 6 to about 8 or about 7 to about 8.
  • a composition has a pH of, e.g., about 6.4 to about 7.4, about 6.5 to about 7.5, about 6.6 to about 7.6, about 6.7 to about 7.7, about 6.6 to about 7.2, about 6.7 to about 7.3, about 6.8 to about 7.4, about 6.9 to about 7.5, about 7.0 to about 7.6, about 6.7 to about 7.1 , about 6.8 to about 7.2, about 6.9 to about 7.3, about 7.0 to about 7.4, about 6.8 to about 7.0, about 6.9 to about 7.1 or about 7.0 to about 7.2.
  • a composition disclosed herein may be applied topically to a skin surface of an individual.
  • a skin surface includes the skin of the arms, legs and torso and head, including the scalp and hair of an individual.
  • a composition disclosed herein may be topically applied to an individual by hand or with an applicator.
  • An applicator includes without limitation, with a sponge, a loofah, a toy, a cotton pad, a wash cloth, a specialized wash cloth, a towel, clothing, a spray bottle, an applicator bottle or any device or article, including a clothing article or applicator.
  • a toy includes, without limitation, a rubber squeeze toy, including, without limitation, a rubber duck, or a plastic squeeze toy.
  • An applicator disclosed herein is preloaded or can be loaded with a composition disclosed herein.
  • An applicator includes an applicator bottle with a roller ball, a push button, a nozzle, a turn nob or other means to apply the composition to an individual.
  • an applicator disclosed herein provides a composition disclosed herein to an individual in metered, defined amounts. For example, metering may be accomplished by pushing down on a nozzle that is part of the applicator.
  • An applicator may also be a squeezable bottle wherein a composition disclosed herein can be dispensed from the bottle as an individual squeezes the bottle.
  • a composition disclosed herein may also be applied using a spray on applicator, including, without limitation, a spray bottle.
  • a composition disclosed herein can be, or combined with, a skin care product.
  • a skin care product include any conventional body wash, after-shower body lotion, shampoo, conditioner, soap, gel, hand sanitizer, cream, spray, mouse, lotion, ointment, make-up product, lip balm, hair spray product, arachnid/insect repellent or medicinal product.
  • a body wash, shampoo, after-shower body lotion, conditioner, soap, gel, hand sanitizer, cream, spray, mouse, lotion, ointment, make-up product, lip balm, hair spray product, arachnid/insect repellent or medicinal product disclosed herein can be, without limitation, any body wash, after-shower body lotion, shampoo, conditioner, soap, gel, hand sanitizer, cream, spray, mouse, lotion, ointment, make-up product, lip balm, hair spray product, arachnid/insect repellent or medicinal product known or apparent to one of skill in the art.
  • a skin care product may be applied by hand, washcloth, or any cleansing article such as a brush, loofah, pouf, sponge, or other to an individual.
  • a bodywash includes, without limitation, a lathering bodywash or a non-lathering bodywash.
  • a bodywash includes, without limitation, an emulsion of water and detergent base with added fragrance and is a skin cleaning agent commonly used in a shower or bath.
  • a bodywash may also contain one or more surfactants.
  • Popular brands such as Fa, Palmolive, Axe, Lynx, Radox, Nivea, Johnson, Senses, Adidas, Umbro, Old Spice, Imperial Leather and right guard.
  • a bodywash also includes, without limitation an all- in-one multifunctional, moisturizing cleanser that both provides SPF and imparts color to the skin after application, wherein the bodywash includes, without limitation, iron oxide pigments as well as red petrolatum, at least one, preferably two, anionic lathering surfactants, a non-ionic lathering surfactant, surface-treated zinc oxide pigments, an alkyl silicone and a volatile cyclic silicone.
  • a spray includes, without limitation, an aerosol spray that includes a propellant.
  • a propellant includes, without limitation is a mixture of isobutane, butane and propane, including, without limitation A46, AP30 (1 1 % propane, 29% isobutane, 60% n-butane); AP40 (22% propane, 24% isobutane, 54% n-butane); andAP70 (31 % propane, 23% isobutane, 46% n-butane).
  • a spray includes, without limitation, hair spray, body spray, for example, without limitation, those sold by AXE, spray on insect protection and spray on deodorant.
  • a shampoo includes, without limitation, sodium lauryl sulfate and/or sodium laureth sulfate with a co-surfactant, including, without limitation, cocamidopropyl betaine in water to form a thick, viscous liquid.
  • a shampoo includes salt, including, without limitation, sodium chloride, a preservative and a fragrance.
  • a shampoo is formulated to maximize the following qualities, without limitation, pleasing foam, easy rinsing, minimal skin or eye irritation, feels thick and/or creamy, pleasant fragrance, low toxicity, good biodegradability, slightly acidic and no or minimal damage to hair.
  • a lotion includes, without limitation, a low to low medium viscosity topical preparation intended for application to unbroken skin.
  • a lotion is an oil-in-water emulsion that includes, without limitation, cetearyl alcohol and an emulgent to prevent separation of these two phases.
  • a lotion contains, without limitation, fragrances, glycerol, petroleum jelly, dyes, preservatives, proteins and stabilizing agents.
  • a lotion includes, without limitation a skin medication such as an antibiotic, antiseptic, antifungal, corticosteroid, anti-acne agents or soothing, smoothing, moisturizing or protective agents, including, without limitation, calamine.
  • a gel includes, without limitation, a solid, jelly-like material that can have properties ranging from soft and weak to hard and tough and include, without limitation, substantially dilute cross-linked system, which exhibit no flow when in a steady-state.
  • a gel includes, without limitation, a hydrogel, an organogel or a xerogel.
  • a conditioner includes, without limitation, hair conditioner, which can include, without limitation, the following ingredients: reconstructors, acidifiers, detanglers, thermal protectors, glossers, oils, surfactants, lubricants, sequestrants, antistatic agents, preservatives and sunscreen active agents.
  • a conditioner includes, without limitation, a pack conditioner, a leave-in conditioner, an ordinary conditioner that includes both pack and leave-in ones and hold conditioners.
  • a hand sanitizer includes, without limitation, isopropanol, ethanol, n-propanol or povidone-iodine.
  • hand sanitizers can contain the following inactive ingredients, without limitation, a thickening agent, including without limitation, polyacrylic acid for alcohol gels, humectants, including without limitation, glycerin for liquid rubs, propylene glycol and essential oils derived from plants.
  • a hand sanitizer is a non-alcohol hand sanitizer, which includes without limitation, a nitrogenous cationic surface- acting agent that includes, without limitation, benzalkonium chloride, triclosan or povidone-iodine.
  • a soap is a salt of a fatty acid.
  • Soaps for cleansing are generally obtained by treating vegetable or animal oils and fats with a strongly alkaline solution. Soaps can be in a solid form, such as a bar or in a decorative shape. Soap can also be a liquid. Other components can be added to soap, without limitation, including oils, fragrances and conditioners.
  • a soap contains a surfactant. In another embodiment, a soap does not contain a surfactant.
  • a soap is a melt and pour soap.
  • the process for a melt and pour soap differs from the cold process, hot process or rebatching process of making soap in that no soap is made (i.e. no actual saponification occurs) in the process; a melt and pour soap base acquired in commerce is melted in a direct heat melter or water jacket melting pot (large double boiler) and additional items such as fragrance, essential oils, moisturizing agents, colorants, or exfoliating agents are added. While still hot, the concoction can be poured into individual molds, tray molds, or blocks which upon cooling can be sliced.
  • a melt and pour soap includes, without limitation, a clear glycerin soap or a white soap made from white coconut oil.
  • a soap is Castile soap.
  • Castile soap is a name used in English-speaking countries for olive oil-based soap made in a style similar to that originating in the Castile region of Spain.
  • Castile soap includes, without limitation, sodium hydroxide, potassium hydroxide and/or ash.
  • a composition disclosed herein is use in combination as an admixture with a skin care product disclosed herein.
  • a composition disclosed herein when combined as an admixture with a skin care product in an amount sufficient to allow the one or more active agents, cationic polymers, film formers, photostabilizing agents, surfactant metal complexes, and additional agents to function properly.
  • a composition disclosed herein is combined with a skin care product in a ratio of, e.g., about 1 .0 part composition to 0.1 , 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1 .1 , 1 .2, 1.3, 1 .4, 1 .5, 1 .6, 1 .7, 1.8, 1.9, 2.0, 2.1 , 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.2, 3.5, 3.7, 4.0, 4.2, 4.5, 4.7, 5.0, 6.0, 7.0, 8.0, 9.0, 10, 11 , 12, 13, 14, 15, 16, 17, 18, 19, 20, 21 , 22, 23, 24, 25, 26, 27, 28, 29, 30, 31 , 32, 33, 34, 35, 36, 37, 38, 39, 40, 41 , 42, 43, 44, 45, 46, 47, 48, 49 or 50 parts skin care product as measured w/w.
  • a composition disclosed herein is combined with a skin care product in a ratio range of, e.g., about 1 .0 part composition to about 0.1 to about 1.0 part skin care product as measured w/w, about 1 .0 part composition to about 0.1 to about 5.0 parts skin care product as measured w/w, about 1 .0 part composition to about 0.1 to about 10 parts skin care product as measured w/w, about 1 .0 part composition to about 0.1 to about 15 parts skin care product as measured w/w, about 1 .0 part composition to about 0.1 to about 20 parts skin care product as measured w/w, about 1 .0 part composition to about 0.5 to about 1 .0 part skin care product as measured w/w, about 1.0 part composition to about 0.5 to about 5.0 parts skin care product as measured w/w, about 1 .0 part composition to about 0.5 to about 10 parts skin care product as measured w/w, about 1 .0 part composition to about 0.5 to about 0.5 to about 0.5 to about 10 parts
  • a composition disclosed herein is formulated as a skin care product.
  • a composition disclosed herein is formulated as a body wash, after-shower body lotion, shampoo, conditioner, soap, gel, hand sanitizer, cream, spray, mouse, lotion, ointment, make-up product, lip balm, hair spray product, arachnid/insect repellent or medicinal product disclosed herein.
  • skin care products include additional ingredients necessary to formulate the skin care product.
  • a composition disclosed herein formulated as a skin care product disclosed herein typically requires the use of one or more surfactants.
  • a surfactant may be cationic, anionic, non-ionic, zwitterionic, amphoteric, or any combination thereof.
  • surfactants include, without limitation, alkyi and alkyi ether sulfates, sulfated monoglycerides, sulfonated olefins, alkyi aryl sulfonates, primary or secondary alkane sulfonates, alkyi sulfosuccinates, acyl taurates, acyl isethionates, alkyi glycerylether sulfonate, sulfonated methyl esters, sulfonated fatty acids, alkyi phosphates, ethoxylated alkyi phosphates, acyl glutamates, acyl sarcosinates, alkyi sulfoacetates, acylated peptides, alkyi ether carboxylates, acyl lactylates, anionic fluorosurfactants, and combinations thereof.
  • alkyi sulfates include, without limitation, sodium, ammonium, potassium, magnesium, or TEA salts of lauryl or myristyl sulfate or ammonium, sodium, magnesium, or TEA laureth-3 sulfate.
  • a composition disclosed herein comprises a surfactant in an amount sufficient to promote or facilitate the function or activity of that surfactant.
  • a composition disclosed herein comprises a surfactant in an amount of, e.g., at least 0.1 %, at least 0.2%, at least 0.3%, at least 0.4%, at least 0.5%, at least 0.6%, at least 0.7%, at least 0.8%, at least 0.9%, at least 1.0%, at least 2.0%, at least 3.0%, at least 4.0%, at least 5.0%, at least 6.0%, at least 7.0%, at least 8.0%, at least 9.0%, at least 10%, at least 11 %, at least 12%, at least 13%, at least 14%, at least 15%, at least 20%, at least 25% of the total weight of the composition.
  • a composition disclosed herein comprises a surfactant in an amount of, e.g., at most 0.1 %, at most 0.2%, at most 0.3%, at most 0.4%, at most 0.5%, at most 0.6%, at most 0.7%, at most 0.8%, at most 0.9%, at most 1.0%, at most 2.0%, at most 3.0%, at most 4.0%, at most 5.0%, at most 6.0%, at most 7.0%, at most 8.0%, at most 9.0%, at most 10%, at most 11 %, at most 12%, at most 13%, at most 14%, at most 15%, at most 20%, at most 25% of the total weight of the composition.
  • a composition disclosed herein comprises a surfactant in an amount of, e.g., about 0.1 % to about 0.5%, about 0.1 % to about 1 .0%, about 0.1 % to about 2.0%, about 0.1 % to about 3.0%, about 0.1 % to about 4.0%, about 0.1 % to about 5.0%, about 0.1 % to about 6.0%, about 0.1 % to about 7.0%, about 0.1 % to about 8.0%, about 0.1 % to about 9.0%, about 0.1 % to about 10%, about 0.5% to about 1.0%, about 0.5% to about 2.0%, about 0.5% to about 3.0%, about 0.5% to about 4.0%, about 0.5% to about 5.0%, about 0.5% to about 6.0%, about 0.5% to about 7.0%, about 0.5% to about 8.0%, about 0.5% to about 9.0%, about 0.5% to about 10%, about 1 .0% to about 2.0%, about 1 .0% to about 3.0%, about 1 .0% to about 4.0%, about
  • a surfactant is an environmentally favourable surfactant including, without limitation, dodecyl glucosides.
  • a surfactant is a lathering surfactant.
  • a lathering surfactant has a log P of less than about 2.5 that produces foam when mixed with and agitated in water.
  • An anionic lathering surfactant is a sulfate, wherein the sulfate is, without limitation, an alkyi sulfate or an alkyi ether sulfate.
  • a sulfate includes, without limitation, sodium laureth sulfate and ammonium laureth sulfate.
  • Sodium laureth sulfate has a molecular formula CH3(CH2)ioCH2(OCH2CH2)2oS03Na and conforms to the following structure:
  • a composition o r a skin care product combined with a composition includes, without limitation, sodium laureth sulfate at a concentration of from about 10% to about 15% or from about 7.5% to about 8.5%.
  • ammonium laureth sulfate is used in combination with an alkyi glucoside, wherein the alkyi glucoside includes, without limitation, decyl glucoside.
  • the combination of ammonium laureth sulfate and decyl glucoside is sold under the tradename Plantaren PS-100 by Cognis.
  • ammonium laureth sulfate in combination with decyl glucoside is present in a composition or body wash, after-shower body lotion, shampoo, conditioner, soap, gel, hand sanitizer, cream, spray, mouse, lotion, ointment, make-up product, lip balm, hair spray product, arachnid/insect repellent or medicinal product combined with a composition at a concentration of from about 5% to about 10%, or from about 7.5% to about 8.5%.
  • a lathering surfactant includes one, two, three or more anionic lathering surfactants, including, without limitation, sulfates, including, without limitation, sodium laureth sulfate and ammonium laureth sulfate.
  • sulfates including, without limitation, sodium laureth sulfate and ammonium laureth sulfate.
  • sodium laureth sulfate and ammonium laureth sulfate are combined with decyl glucoside.
  • the two sulfates are present at a combined concentration of from about 15% to about 25%.
  • a composition disclosed herein includes, without limitation, at least one cationic surfactant.
  • cationic surfactants include, without limitation, fatty amines, di-fatty quaternary amines, tri-fatty quaternary amines, imidazolinium quaternary amines, and combinations thereof.
  • fatty amines include, without limitation, monalkyl quaternary amines such as cetyltrimethylammonium bromide.
  • quaternary amine include, without limitation, dialklamidoethyl hydroxyethylmonium methosulfate
  • a composition disclosed herein includes, without limitation, stearyldimenthylbenzyl ammonium chloride; dodecyltrimethylammonium chloride; nonylbenzylethyldimethyl ammonium nitrate; tetradecylpyridinium bromide; laurylpyridinium chloride; cetylpyridinium chloride; laurylpyridinium chloride; laurylisoquinolium bromide; ditallow(Hydrogenated)dimethyl ammonium chloride; dilauryldimethyl ammonium chloride; and stearalkonium chloride.
  • anionic surfactants include, without limitation, sulfated monoglycerides of the form R CO-0-CH2-C(OH)H-CH2-0-S03M, wherein R is a saturated or unsaturated, branched or unbranched alkyl group from about 8 to about 24 carbon atoms, and M is a water-soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine, monoethanolamine and sodium cocomonoglyceride sulfate.
  • anionic surfactants include, without limitation, olefin sulfonates of the form R SOsM, wherein R1 is a mono-olefin having from about 12 to about 24 carbon atoms, and M is a water-soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine.
  • a sulfonated olefin is sodium C14/C16 a-olefin sulfonate.
  • anionic surfactants include, without limitation, linear alkylbenzene sulfonates of the form R -C6H4-S03M, wherein R is a saturated or unsaturated, branched or unbranched alkyl group from about 8 to about 24 carbon atoms, and M is a water-soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine monoethanolamine and sodium dodecylbenzene sulfonate.
  • anionic surfactants include, without limitation, primary or secondary alkane sulfonates of the form R S03M, wherein R is a saturated or unsaturated, branched or unbranched alkyl chain from about 8 to about 24 carbon atoms, and M is a water-soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine.
  • alkane sulfonate include, without limitation, alkali metal or ammonium paraffin sulfonates.
  • anionic surfactants include, without limitation, alkyl sulfosuccinates, which include disodium N-octadecylsulfosuccinamate, diammonium lauryl sulfosuccinate, disodium laureth sulfosuccinate, tetrasodium N-(1 ,2-dicarboxyethyl)-N-octadecylsulfosuccinate, diamyl ester of sodium sulfosuccinic acid, dihexyl ester of sodium sulfosuccinic acid and dioctyl esters of sodium sulfosuccinic acid; sodium dodecyl sulfate (or sodium lauryl sulfate), sodium laureth sulfate and ammonium lauryl sulfate.
  • alkyl sulfosuccinates which include disodium N-octadecy
  • Acyl taurate surfactants include, without limitation, taurine, N-alkyltaurines such as the one prepared by reacting dodecylamine with sodium isethionate as detailed in U.S. Pat. No. 2,658,072, and coconut fatty acid salts, such as, e.g., sodium methyl cocoyl taurate and sodium methyl oleoyl taurate.
  • anionic surfactants include, without limitation, acyl isethionates, including, without limitation, acyl isethionates include ammonium cocoyl isethionate, sodium cocoyl isethionate, sodium lauroyl isethionate, alkylglyceryl ether sulfonates of the form R -OCH2-C(OH)H-CH2- SO3M, wherein R is a saturated or unsaturated, branched or unbranched alkyl group from about 8 to about 24 carbon atoms, and M is a water-soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine, sodium cocoglyceryl ether sulfonate, sulfonated fatty acids of the form R -CH(S04)-COOH and sulfonated methyl esters of the from R -CH(S04)-CO-0-CH3, where R is a saturated
  • a soap is a semi-solid.
  • a soap includes a wax to form a solid soap bar.
  • a counter cation, M is used on the anionic surfactant.
  • a counter cation includes, without limitation, sodium, potassium, ammonium, monoethanolamine, diethanolamine, and triethanolamine.
  • non-ionic surfactants include, without limitation, alkyl glucosides, alkyl polyglucosides, polyhydroxy fatty acid amides, alkoxylated fatty acid esters, sucrose esters, amine oxides, and mixtures thereof.
  • Alkyl glucosides and alkyl polyglucosides are condensation products of long chain alcohols, including, without limitation, Cs-3o alcohols, with sugars or starches or sugar or starch polymers, including, without limitation, glycosides or polyg lycos ides and are represented by the formula (S)n-O-R wherein S is a sugar moiety such as glucose, fructose, mannose, and galactose; n is an integer of from about 1 to about 1000, and R is a Cs-3o alkyl group.
  • long chain alcohols from which the alkyl group can be derived include, without limitation, decyl alcohol, cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol, oleyl alcohol, and more.
  • these surfactants include, without limitation, those wherein S is a glucose moiety, R is a Cs-2o alkyl group, and n is an integer of from about 1 to about 9.
  • Commercially available examples of these surfactants include decyl polyglucoside (available as APG 325 CS from Henkel) and lauryl polyglucoside (available as APG 600CS and 625 CS from Henkel).
  • sucrose ester surfactants include, without limitation, sucrose cocoate and sucrose laurate.
  • non-ionic surfactants include, without limitation, polyhydroxy fatty acid amide surfactants, more specific examples of which include glucosamides.
  • a process for making compositions containing polyhydroxy fatty acid amides are disclosed, for example, in G.B. Pat. Specification 809,060, published Feb. 18, 1959, by Thomas Hedley & Co., Ltd.; U.S. Pat. No. 2,965,576, to E. R. Wilson, issued Dec. 20, 1960; U.S. Patents 2,703,798, to A. M. Schwartz, issued Mar. 8, 1955; and U.S. Pat. No. 1 ,985,424, to Piggott, issued Dec. 25, 1934.
  • non-ionic surfactants include, without limitation, amine oxides, including, without limitation, those corresponding to the general formula R1 R2, R3NO, wherein Ri contains an alkyl, alkenyl or monohydroxy alkyl radical of from about 8 to about 18 carbon atoms, from 0 to about 10 ethylene oxide moieties, and from 0 to about 1 glyceryl moiety, and R2 and R3 contain from about 1 to about 3 carbon atoms and from 0 to about 1 hydroxy group, e.g., methyl, ethyl, propyl, hydroxyethyl, or hydroxypropyl radicals.
  • the arrow in the formula is a conventional representation of a semipolar bond.
  • amine oxides include, without limitation, dimethyl-dodecylamine oxide, oleyldi(2-hydroxyethyl) amine oxide, dimethyloctylamine oxide, dimethyl-decylamine oxide, dimethyl-tetradecylamine oxide, 3,6,9-trioxaheptadecyldiethylamine oxide, di(2-hydroxyethyl)-tetradecylamine oxide, 2-dodecoxyethyldimethylamine oxide, 3-dodecoxy-2- hydroxypropyldi(3-hydroxypropyl)amine oxide, dimethylhexadecylamine oxide.
  • amphoteric surfactant is also intended to encompass zwitterionic surfactants, which are well known to formulators skilled in the art as a subset of amphoteric surfactants.
  • Amphoteric lathering surfactants include, without limitation, derivatives of aliphatic secondary and tertiary amines, including, without limitation, those wherein the nitrogen is in a cationic state, in which the aliphatic radicals can be straight or branched chain and wherein one of the radicals contains an ionizable water solubilizing group, e.g., carboxy, sulfonate, sulfate, phosphate, or phosphonate.
  • amphoteric or zwitterionic surfactants include, without limitation, betaines, sultaines, hydroxysultaines, alkyliminoacetates, iminodialkanoates, aminoalkanoates, and mixtures thereof.
  • betaines include, without limitation, the higher alkyl betaines, such as coco dimethyl carboxymethyl betaine, lauryl dimethyl carboxymethyl betaine, lauryl dimethyl a-carboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, cetyl dimethyl betaine (available as Lonzaine 16SP from Lonza Corp.), lauryl bis- (2-hydroxyethyl) carboxymethyl betaine, oleyl dimethyl gamma-carboxypropyl betaine, lauryl bis-(2- hydroxypropyl)a-carboxyethyl betaine, coco dimethyl sulfopropyl betaine, lauryl dimethyl sulfoethyl betaine, lauryl bis-(2-hydroxyethyl) sulfopropyl betaine, amidobetaines and amidosulfobetaines (wherein the RCONH(CH2)3 radical is attached to the nitrogen atom of the betaine), oley
  • amphoteric surfactants include, without limitation, the following compounds: Cetyl dimethyl betaine (this material also has the CTFA designation cetyl betaine); Cocamidopropylbetaine; Cocamidopropyl hydroxy sultaine.
  • amphoteric surfactants examples include alkyliminoacetates, and iminodialkanoates and aminoalkanoates of the formulas RN[(CH2)-C02-M]2 and RNH(CH2)mC02 M wherein m is from 1 to 4, R is a C8-C22 alkyl or alkenyl, and M is H, alkali metal, alkaline earth metal ammonium, alkanolammonium or imidazolinium and ammonium derivatives.
  • amphoteric surfactants include, without limitation, sodium 3- dodecyl-aminopropionate, sodium 3-dodecylaminopropane sulfonate.
  • N-higher alkyl aspartic acids include, without limitation, those produced according to the teaching of U.S. Patent 2,438,091 ; and the products sold under the trade name "Miranol” and described in U.S. Patent 2,528,378.
  • amphoterics include, without limitation, amphoteric phosphates, such as coamidopropyl PG-dimonium chloride phosphate (commercially available as Monaquat PTC, from Mona Corp.).
  • amphoacetates include, without limitation, disodium lauroamphodiacetate, sodium lauroamphoacetate, and mixtures thereof.
  • a bodywash is, without limitation, SUAVE Body Wash, which has the following ingredients: Water, Ammonium Lauryl Sulfate, Ammonium Laureth Sulfate, Cocamidopropyl Betaine, Fragrance, Glycerin, Hydrolyzed Milk Protein & Honey Extract, PEG-10 Sunflower Glycerides, Cocamide MEA, Guar Hydroxypropylrimonium Chloride, Acrylates Copolymer, PEG-5 Cocamide, Helianthus Annuus (Sunflower) Seed Oil or Glycine Soja (Soybean) Oil, Tetrasoidum EDTA, Propylene Glycol, Ammonium Chloride, Sodium Hydroxide, Methylchloroisothiazolinone, Methylisothiazolinone, Titanium Dioxide (CI 77891).
  • soapless cleansers are used in addition to, or instead of, soaps/surfactants, including, without limitation OILATUMTM AD (registered trademark, Stiefel Laboratories) AQUANILTM (registered trademark, Person & Covey, Inc.), CETAPHILTM (trademark, Galderma Laboratories, Inc.) or SPECTRODERMTM (registered trademark, Draxis Pharmaceutical Inc.), or their equivalents, may be utilized as a soapless component in the present invention.
  • OILATUMTM AD registered trademark, Stiefel Laboratories
  • AQUANILTM registered trademark, Person & Covey, Inc.
  • CETAPHILTM trademark, Galderma Laboratories, Inc.
  • SPECTRODERMTM registered trademark, Draxis Pharmaceutical Inc.
  • the composition containing an active agent is a powder or other dry form.
  • the composition containing an active agent is applied to an individual by applying the powder or other dry form to the individual.
  • the composition containing an active agent is rubbed, massaged, caressed onto the individual.
  • the composition containing an active agent that is in the form of a powder or other dry form is stored in an applicator.
  • the applicator is the same as the applicator used for powder or other dry form products, including, without limitation, a baby powder bottle or other applicator that is conformed to the application of a powder or other dry form of a composition.
  • the components comprising a composition are mixed in, without limitation, water or oil.
  • a composition or composition combined with a body wash, after-shower body lotion, shampoo, conditioner, soap, gel, hand sanitizer, cream, spray, mouse, lotion, ointment, make-up product, lip balm, hair spray product, arachnid/insect repellent or medicinal product includes, without limitation, one or more surfactants.
  • surfactants in bodywashes is well-known in the art.
  • any surfactant known in the art and appropriate for a body wash, after-shower body lotion, shampoo, conditioner, soap, gel, hand sanitizer, cream, spray, mouse, lotion, ointment, make-up product, lip balm, hair spray product, arachnid/insect repellent or medicinal product may be used. See, McCutcheon's Detergents & Emulsifiers, M.C. Publishing Co. (North American edition 1989); Schwartz, et al., Surface Active Agents, Their Chemistry and Technology, New York, Interscience Publishers, 1949, and U.S.
  • a composition disclosed herein comprises one or more cellulose derived encapsulates and/or one or more sol-gel encapsulates comprising one or more moisturizing agents.
  • a composition disclosed herein comprises about 0.1 % to about 20%, about 0.5% to about 15%, about 1 % to about 10%, about 2% to about 7%, about 3% to about 5% or about 4% by weight of the total composition of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents.
  • a composition disclosed herein comprises about 0.1 % to about 20%, about 0.5% to about 15%, about 0.75% to about 12%, about 1 % to about 10%, about 5% to about 7% or about 6% by weight of the total composition of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents.
  • a composition disclosed herein comprises about 2% to about 40%, about 3% to about 38%, about 4% to about 36%, about 5% to about 36%, about 6% to about 34%, about 8% to about 32%, about 10% to about 30%, about 12% to about 28%, about 14% to about 26%, about 16% to about 24%, or about 18% to about 22%, by weight of the total composition of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents.
  • the one or more cellulose encapsulates and/or one or more sol-gel encapsulates disclosed herein comprises about 1 % to about 5% of a first moisturizing agent, about 95% to about 99% of a second moisturizing agent, about 6% to about 10% of a first moisturizing agent, about 90% to about 94% of a second moisturizing agent, about 1 1 % to about 15% of a first moisturizing agent, about 85% to about 89% of a second moisturizing agent, about 16% to about 20% of a first moisturizing agent, about 80% to about 84% of a second moisturizing agent, about 21 % to about 25% of a first moisturizing agent, about 75% to about 79% of a second moisturizing agent, about 26% to about 30% of a first moisturizing agent, about 70% to about 74% of a second moisturizing agent, about 31 % to about 35% of a first moisturizing agent, about 65% to about 69% of a
  • a composition is a body wash, a shampoo, an after-shower body lotion, a conditioner, a soap, a gel, a hand sanitizer, a cream, a spray, a mouse, a lotion, an ointment, a make-up product, a lip balm, a hair spray product, an arachnid/insect repellent or a medicinal product.
  • a moisturizing agent comprises amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, glucose, glycerin, glycerol polymers, glycol, 1 ,2,6- hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factor, PEG-15 butanediol, polyglyceryl sorbitol, saccharide isomerate, salts of pyrrolidone carboxylic acid, potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol.
  • a composition disclosed herein further comprises a film former.
  • a composition disclosed herein comprises about 1 % to about 6%, about 1 .5% to about 4.5%, about 2% to about 4%, about 2.5% to about 3.5% or about 3% of a film former.
  • a composition disclosed herein comprises an acrylate copolymer as a film former.
  • a composition disclosed herein comprises DERMACRYL ® AQF as a film former.
  • a composition disclosed herein further comprise one or more surfactants.
  • a composition disclosed herein comprises about 0.1 % to about 20%, about 0.25% to about 18%, about 0.5% to about 15%, about 0.5% to about 12%, about 0.75% to about 10%, about 1 % to about 8%, of one or more surfactants.
  • additional surfactants include additional cationic surfactants, anionic surfactants, non-ionic surfactants, zwitterionic surfactants, amphoteric surfactants, or any combination thereof.
  • a composition disclosed herein comprises a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, one or more polyquaterniums, and one or more surfactants.
  • a composition is a body wash, a shampoo, an after-shower body lotion, a conditioner, a soap, a gel, a hand sanitizer, a cream, a spray, a mouse, a lotion, an ointment, a make-up product, a lip balm, a hair spray product, an arachnid/insect repellent or a medicinal product.
  • a moisturizing agent comprises amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, glucose, glycerin, glycerol polymers, glycol, 1 ,2,6- hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factor, PEG-15 butanediol, polyglyceryl sorbitol, saccharide isomerate, salts of pyrrolidone carboxylic acid, potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol.
  • a composition comprises about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, and about 3% to about 17% one or more surfactants.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.2% to about 8% of one or more polyquaterniums, and about 5% to about 15% one or more surfactants.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.4% to about 6% of one or more polyquaterniums, and about 7% to about 13% one or more surfactants.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.6% to about 5% of one or more polyquaterniums, and about 9% to about 11 % one or more surfactants.
  • a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, and about 10% one or more surfactants.
  • a composition comprises about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, and about 3% to about 17% one or more surfactants.
  • a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.2% to about 8% of one or more polyquaterniums, and about 5% to about 15% one or more surfactants.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.4% to about 6% of one or more polyquaterniums, and about 7% to about 13% one or more surfactants.
  • a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.6% to about 5% of one or more polyquaterniums, and about 9% to about 11 % one or more surfactants.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, and about 10% one or more surfactants.
  • a composition disclosed herein comprises about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, and about 2% to about 18% one or more surfactants.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.2% to about 8% of one or more polyquaterniums, and about 3% to about 15% one or more surfactants.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.4% to about 6% of one or more polyquaterniums, and about 4% to about 13% one or more surfactants.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.6% to about 5% of one or more polyquaterniums, and about 5% to about 12% one or more surfactants.
  • a disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, and about 6% to about 1 1 % one or more surfactants.
  • a composition disclosed herein comprises about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, and about 2% to about 18% one or more surfactants.
  • a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.2% to about 8% of one or more polyquaterniums, and about 3% to about 15% one or more surfactants.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.4% to about 6% of one or more polyquaterniums, and about 4% to about 13% one or more surfactants.
  • a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.6% to about 5% of one or more polyquaterniums, and about 5% to about 12% one or more surfactants.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, and about 6% to about 1 1 % one or more surfactants.
  • a composition disclosed herein comprises about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, and about 1 % to about 20% one or more surfactants.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 5% of one or more polyquaterniums, and about 4% to about 14% one or more surfactants.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 3% of one or more polyquaterniums, and about 7% to about 1 1 % one or more surfactants.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.25% to about 2.5% of one or more polyquaterniums, and about 8% to about 10% one or more surfactants.
  • a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% of one or more polyquaterniums, and about 8.8% one or more surfactants.
  • a composition disclosed herein comprises about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, and about 1 % to about 20% one or more surfactants.
  • a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 5% of one or more polyquaterniums, and about 4% to about 14% one or more surfactants.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 3% of one or more polyquaterniums, and about 7% to about 1 1 % one or more surfactants.
  • a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.25% to about 2.5% of one or more polyquaterniums, and about 8% to about 10% one or more surfactants.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% of one or more polyquaterniums, and about 8.8% one or more surfactants.
  • a composition disclosed herein comprises about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, about 0.5% to about 15% one or more anionic surfactants, about 0.1 % to about 5% one or more amphoteric surfactants and about 0.1 % to about 5% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.2% to about 8% of one or more polyquaterniums, about 0.5% to about 10% one or more anionic surfactants, about 0.25% to about 4% one or more amphoteric surfactants and about 0.25% to about 4% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.4% to about 6% of one or more polyquaterniums, about 2% to about 9% one or more anionic surfactants, about 0.5% to about 3% one or more amphoteric surfactants and about 0.5% to about 3% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.6% to about 5% of one or more polyquaterniums, about 3% to about 8% one or more anionic surfactants, about 0.75% to about 2.5% one or more amphoteric surfactants and about 0.75% to about 2.5% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, about 4% to about 7% one or more anionic surfactants, about 1 % to about 2% one or more amphoteric surfactants and about 1 % to about 2% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 20% of one or more polyquaterniums, about 0.5% to about 15% one or more anionic surfactants, about 0.1 % to about 5% one or more amphoteric surfactants and about 0.1 % to about 5% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.2% to about 8% of one or more polyquaterniums, about 1 % to about 10% one or more anionic surfactants, about 0.25% to about 4% one or more amphoteric surfactants and about 0.25% to about 4% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.4% to about 6% of one or more polyquaterniums, about 2% to about 9% one or more anionic surfactants, about 0.5% to about 3% one or more amphoteric surfactants and about 0.5% to about 3% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.6% to about 5% of one or more polyquaterniums, about 3% to about 8% one or more anionic surfactants, about 0.75% to about 2.5% one or more amphoteric surfactants and about 0.75% to about 2.5% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, about 4% to about 7% one or more anionic surfactants, about 1 % to about 2% one or more amphoteric surfactants and about 1 % to about 2% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, about 1 % to about 16% of one or more anionic surfactants, about 0.1 % to about 10% of an amphoteric surfactant and about 0.1 % to about 10% of a surfactant.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 5% of one or more polyquaterniums, about 1 % to about 12% of one or more anionic surfactants, about 0.25% to about 8% of an amphoteric surfactant and about 0.25% to about 8% of a surfactant.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 3% of one or more polyquaterniums, about 3% to about 9% of one or more anionic surfactants, about 0.5% to about 5% of an amphoteric surfactant and about 0.5% to about 5% of a surfactant.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol- gel encapsulate comprising one or more moisturizing agents, about 0.25% to about 2.5% of one or more polyquaterniums, about 5% to about 7% of one or more anionic surfactants, about 1 % to about 3% of an amphoteric surfactant and about 1 % to about 3% of a surfactant.
  • a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% of one or more polyquaterniums, about 5.6% of one or more anionic surfactants, about 1 .6% of an amphoteric surfactant and about 1 .6% of a surfactant.
  • a composition disclosed herein comprises about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, about 1 % to about 16% of one or more anionic surfactants, about 0.1 % to about 10% of an amphoteric surfactant and about 0.1 % to about 10% of a surfactant.
  • a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 5% of one or more polyquaterniums, about 1 % to about 12% of one or more anionic surfactants, about 0.25% to about 8% of an amphoteric surfactant and about 0.25% to about 8% of a surfactant.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 3% of one or more polyquaterniums, about 3% to about 9% of one or more anionic surfactants, about 0.5% to about 5% of an amphoteric surfactant and about 0.5% to about 5% of a surfactant.
  • a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol- gel encapsulate comprising one or more moisturizing agents, about 0.25% to about 2.5% of one or more polyquaterniums, about 5% to about 7% of one or more anionic surfactants, about 1 % to about 3% of an amphoteric surfactant and about 1 % to about 3% of a surfactant.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% of one or more polyquaterniums, about 5.6% of one or more anionic surfactants, about 1 .6% of an amphoteric surfactant and about 1 .6% of a surfactant.
  • a composition disclosed herein comprises about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, about 0.5% to about 8% one or more alkyl sulfosuccinate surfactants, about 0.1 % to about 5% one or more acyl isethionate surfactants, about 0.1 % to about 5% one or more betaine surfactants and about 0.1 % to about 5% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.2% to about 8% of one or more polyquaterniums, about 1 % to about 7% one or more alkyl sulfosuccinate surfactants, about 0.25% to about 4% one or more acyl isethionate surfactants, about 0.25% to about 4% one or more betaine surfactants and about 0.25% to about 4% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.4% to about 6% of one or more polyquaterniums, about 2% to about 6% one or more alkyl sulfosuccinate surfactants, about 0.5% to about 3% one or more acyl isethionate surfactants, about 0.5% to about 3% one or more betaine surfactants and about 0.5% to about 3% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.6% to about 5% of one or more polyquaterniums, about 2.5% to about 5% one or more alkyl sulfosuccinate surfactants, about 0.75% to about 2.5% one or more acyl isethionate surfactants, about 0.75% to about 2.5% one or more betaine surfactants and about 0.75% to about 2.5% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, about 3% to about 4.5% one or more alkyl sulfosuccinate surfactants, about 1 % to about 2% one or more acyl isethionate surfactants, about 1 % to about 2% one or more betaine surfactants and about 1 % to about 2% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 30% of one or more polyquaterniums, about 0.5% to about 8% one or more alkyl sulfosuccinate surfactants, about 0.1 % to about 5% one or more acyl isethionate surfactants, about 0.1 % to about 5% one or more betaine surfactants and about 0.1 % to about 5% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% to about 15% of one or more polyquaterniums, about 1 % to about 7% one or more alkyl sulfosuccinate surfactants, about 0.25% to about 4% one or more acyl isethionate surfactants, about 0.25% to about 4% one or more betaine surfactants and about 0.25% to about 4% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.4% to about 6% of one or more polyquaterniums, about 2% to about 6% one or more alkyl sulfosuccinate surfactants, about 0.5% to about 3% one or more acyl isethionate surfactants, about 0.5% to about 3% one or more betaine surfactants and about 0.5% to about 3% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.6% to about 5% of one or more polyquaterniums, about 2.5% to about 5% one or more alkyl sulfosuccinate surfactants, about 0.75% to about 2.5% one or more acyl isethionate surfactants, about 0.75% to about 2.5% one or more betaine surfactants and about 0.75% to about 2.5% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, about 3% to about 4.5% one or more alkyl sulfosuccinate surfactants, about 1 % to about 2% one or more acyl isethionate surfactants, about 1 % to about 2% one or more betaine surfactants and about 1 % to about 2% one or more acyl taurate surfactants.
  • a composition disclosed herein comprises about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of a polyquaternium, about 0.1 % to about 15% of an alkyl sulfosuccinate surfactant, about 0.1 % to about 10% of an isethionate surfactant, about 0.1 % to about 10% of a betaine surfactant and about 0.1 % to about 10% of an acyl taurate surfactant.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 5% of a polyquaternium, about 0.5% to about 10% of an alkyl sulfosuccinate surfactant, about 0.25% to about 8% of an isethionate surfactant, about 0.25% to about 8% of a betaine surfactant and about 0.25% to about 8% of an acyl taurate surfactant.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol- gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 3% of a polyquaternium, about 1 % to about 7% of an alkyl sulfosuccinate surfactant, about 0.5% to about 5% of an isethionate surfactant, about 0.5% to about 5% of a betaine surfactant and about 0.5% to about 5% of an acyl taurate surfactant.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.25% to about 2.5% of a polyquaternium, about 3% to about 5% of an alkyl sulfosuccinate surfactant, about 1 % to about 3% of an isethionate surfactant, about 1 % to about 3% of a betaine surfactant and about 1 % to about 3% of an acyl taurate surfactant.
  • a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% of a polyquaternium, about 4% of an alkyl sulfosuccinate surfactant, about 1 .6% of an isethionate surfactant, about 1.6% of a betaine surfactant and about 1.6% of an acyl taurate surfactant.
  • a composition disclosed herein comprises about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of a polyquaternium, about 0.1 % to about 15% of an alkyl sulfosuccinate surfactant, about 0.1 % to about 10% of an isethionate surfactant, about 0.1 % to about 10% of a betaine surfactant and about 0.1 % to about 10% of an acyl taurate surfactant.
  • a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 5% of a polyquaternium, about 0.5% to about 10% of an alkyl sulfosuccinate surfactant, about 0.25% to about 8% of an isethionate surfactant, about 0.25% to about 8% of a betaine surfactant and about 0.25% to about 8% of an acyl taurate surfactant.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 3% of a polyquaternium, about 1 % to about 7% of an alkyl sulfosuccinate surfactant, about 0.5% to about 5% of an isethionate surfactant, about 0.5% to about 5% of a betaine surfactant and about 0.5% to about 5% of an acyl taurate surfactant.
  • a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.25% to about 2.5% of a polyquaternium, about 3% to about 5% of an alkyl sulfosuccinate surfactant, about 1 % to about 3% of an isethionate surfactant, about 1 % to about 3% of a betaine surfactant and about 1 % to about 3% of an acyl taurate surfactant.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% of a polyquaternium, about 4% of an alkyl sulfosuccinate surfactant, about 1 .6% of an isethionate surfactant, about 1.6% of a betaine surfactant and about 1.6% of an acyl taurate surfactant.
  • a composition disclosed herein comprises a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, one or more emollients and one or more thickening agents.
  • a composition is a body wash, a shampoo, an after-shower body lotion, a conditioner, a soap, a gel, a hand sanitizer, a cream, a spray, a mouse, a lotion, an ointment, a make-up product, a lip balm, a hair spray product, an arachnid/insect repellent or a medicinal product.
  • a moisturizing agent comprises amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, glucose, glycerin, glycerol polymers, glycol, 1 ,2,6- hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factor, PEG-15 butanediol, polyglyceryl sorbitol, saccharide isomerate, salts of pyrrolidone carboxylic acid, potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol.
  • a composition disclosed herein comprises about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.25% to about 10% one or more emollients and about 0.5% to about 12% one or more thickening agents.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% to about 8% one or more emollients and about 1 % to about 10% one or more thickening agents.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 1 % to about 6% one or more emollients and about 1 .5% to about 8.5% one or more thickening agents.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2% to about 5% one or more emollients and about 2.5% to about 6.5% one or more thickening agents.
  • a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 3.4% one or more emollients and about 4.5% one or more thickening agents.
  • a composition disclosed herein comprises about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.25% to about 10% one or more emollients and about 0.5% to about 12% one or more thickening agents.
  • a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% to about 8% one or more emollients and about 1 % to about 10% one or more thickening agents.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 1 % to about 6% one or more emollients and about 1 .5% to about 8.5% one or more thickening agents.
  • a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2% to about 5% one or more emollients and about 2.5% to about 6.5% one or more thickening agents.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 3.4% one or more emollients and about 4.5% one or more thickening agents.
  • a composition disclosed herein comprises about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.25% to about 10% one or more emollients, about 0.1 % to about 9% one or more silicone elastomer thickening agents and about 0.1 % to about 9% one or more sodium acryiate-sodium acryioy!dimethy! taurate copoiymer-hased thickening agents.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% to about 8% one or more emollients, about 0.2% to about 7% one or more silicone elastomer thickening agents and about 0.2% to about 7% one or more sodium acry!ate-sodium acryioy!dimeihyS taurate eopo!ymer-based thickening agents.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 1 % to about 6% one or more emollients, about 0.25% to about 5% one or more silicone elastomer thickening agents and about 0.5% to about 5% one or more sodium acryiate-sodium acryioy!dimethyi taurate copolymer-based thickening agents.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol- gel encapsulate comprising one or more moisturizing agents, about 2% to about 5% one or more emollients, about 0.5% to about 3.5% one or more silicone elastomer thickening agents and about 1 % to about 4% one or more sodium acry!ate-sodium a yioyidimeihyi taurate copo!ymer-based thickening agents.
  • a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 3.5% one or more emollients, about 2% one or more silicone elastomer thickening agents and about 2.5% one or more sodium acry!ate-sodium acryioyldimeihyi taurate copo!ymer-based thickening agents.
  • a composition disclosed herein comprises about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.25% to about 10% one or more emollients, about 0.1 % to about 9% one or more silicone elastomer thickening agents and about 0.1 % to about 9% one or more sodium aeryiate-sodium aery!oy!dimethyi taurate eopoiymer-based thickening agents.
  • a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% to about 8% one or more emollients, about 0.2% to about 7% one or more silicone elastomer thickening agents and about 0.2% to about 7% one or more sodium acrylate-sodium acryioy!dimethyl taurate copoiymer-based thickening agents.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 1 % to about 6% one or more emollients, about 0.25% to about 5% one or more silicone elastomer thickening agents and about 0.5% to about 5% one or more sodium acrylate- sodium acry!oyidimeihy! taurate copoiymer-based thickening agents.
  • a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2% to about 5% one or more emollients, about 0.5% to about 3.5% one or more silicone elastomer thickening agents and about 1 % to about 4% one or more sodium aeryiate-sodium acryioyidimeihy! taurate copo!ymei-based thickening agents.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 3.5% one or more emollients, about 2% one or more silicone elastomer thickening agents and about 2.5% one or more sodium acrylate-sodium acryloyidimethyi taurate copoiymer-based thickening agents.
  • a composition disclosed herein comprises a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, one or more polyquaterniums, one or more film formers, one or more emollients and one or more thickening agents.
  • a composition is a body wash, a shampoo, an after-shower body lotion, a conditioner, a soap, a gel, a hand sanitizer, a cream, a spray, a mouse, a lotion, an ointment, a make-up product, a lip balm, a hair spray product, an arachnid/insect repellent or a medicinal product.
  • a moisturizing agent comprises amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, glucose, glycerin, glycerol polymers, glycol, 1 ,2,6-hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factor, PEG-15 butanediol, polyglyceryl sorbitol, saccharide isomerate, salts of pyrrolidone carboxylic acid, potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol.
  • a composition disclosed herein comprises about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% to about 8% of one or more polyquaterniums, about 0.5% to about 8% of one or more film formers, about 0.25% to about 10% one or more emollients and about 0.5% to about 12% one or more thickening agents.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 1 % to about 5% of one or more polyquaterniums, about 1 % to about 5% of one or more film formers, about 0.5% to about 8% one or more emollients and about 1 % to about 10% one or more thickening agents.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 1 .5% to about 3.5% of one or more polyquaterniums, about 1 .5% to about 3.5% of one or more film formers, about 1 % to about 6% one or more emollients and about 1 .5% to about 8.5% one or more thickening agents.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2% to about 3% of one or more polyquaterniums, about 2% to about 3% of one or more film formers, about 2% to about 5% one or more emollients and about 2.5% to about 6.5% one or more thickening agents.
  • a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, about 2.5% of one or more film formers, about 3.4% one or more emollients and about 4.5% one or more thickening agents.
  • a composition disclosed herein comprises about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% to about 8% of one or more polyquaterniums, about 0.5% to about 8% of one or more film formers, about 0.25% to about 10% one or more emollients and about 0.5% to about 12% one or more thickening agents.
  • a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 1 % to about 5% of one or more polyquaterniums, about 1 % to about 5% of one or more film formers, about 0.5% to about 8% one or more emollients and about 1 % to about 10% one or more thickening agents.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 1 .5% to about 3.5% of one or more polyquaterniums, about 1 .5% to about 3.5% of one or more film formers, about 1 % to about 6% one or more emollients and about 1 .5% to about 8.5% one or more thickening agents.
  • a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2% to about 3% of one or more polyquaterniums, about 2% to about 3% of one or more film formers, about 2% to about 5% one or more emollients and about 2.5% to about 6.5% one or more thickening agents.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, about 2.5% of one or more film formers, about 3.4% one or more emollients and about 4.5% one or more thickening agents.
  • a composition disclosed herein comprises about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% to about 8% of one or more polyquaterniums, about 0.5% to about 8% of one or more acrylate copolymers, about 0.25% to about 10% one or more emollients, about 0.1 % to about 9% one or more silicone elastomer thickening agents and about 0.1 % to about 9% one or more sodium acrylate- sodium acry!oy!dimeihy! iauraie copo!ymer-based thickening agents.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 1 % to about 5% of one or more polyquaterniums, about 1 % to about 5% of one or more acrylate copolymers, about 0.5% to about 8% one or more emollients, about 0.2% to about 7% one or more silicone elastomer thickening agents and about 0.2% to about 7% one or more sodium acrylaie-sodium acry!oyldimethyl Iauraie copo!ymer-based thickening agents.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 1 .5% to about 3.5% of one or more polyquaterniums, about 1.5% to about 3.5% of one or more acrylate copolymers, about 1 % to about 6% one or more emollients, about 0.25% to about 5% one or more silicone elastomer thickening agents and about 0.5% to about 5% one or more sodium acrylaie-sodium acryioyidimethyi iauraie copo!ymer-based thickening agents.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2% to about 3% of one or more polyquaterniums, about 2% to about 3% of one or more acrylate copolymers, about 2% to about 5% one or more emollients, about 0.5% to about 3.5% one or more silicone elastomer thickening agents and about 1 % to about 4% one or more sodium acrylaie-sodium acry!oyklimeihyl iauraie copo!ymer-based thickening agents.
  • a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, about 2.5% of one or more acrylate copolymers, about 3.5% one or more emollients, about 2% one or more silicone elastomer thickening agents and about 2.5% one or more sodium acrylate-sodium acryioyidimethyi taurate copolymer-based thickening agents.
  • a composition disclosed herein comprises about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% to about 8% of one or more polyquaterniums, about 0.5% to about 8% of one or more acrylate copolymers, about 0.25% to about 10% one or more emollients, about 0.1 % to about 9% one or more silicone elastomer thickening agents and about 0.1 % to about 9% one or more sodium acrylate- sodium acryioyidimethyi iauraie copo!ymer-based thickening agents.
  • a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 1 % to about 5% of one or more polyquaterniums, about 1 % to about 5% of one or more acrylate copolymers, about 0.5% to about 8% one or more emollients, about 0.2% to about 7% one or more silicone elastomer thickening agents and about 0.2% to about 7% one or more sodium acryiate-sodium acryloyidSmethy! taurate copolymer-based thickening agents.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 1 .5% to about 3.5% of one or more polyquaterniums, about 1.5% to about 3.5% of one or more acrylate copolymers, about 1 % to about 6% one or more emollients, about 0.25% to about 5% one or more silicone elastomer thickening agents and about 0.5% to about 5% one or more sodium acryiate-sodium acfyioyidimeihyi taurate copo!ymer-based thickening agents.
  • a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2% to about 3% of one or more polyquaterniums, about 2% to about 3% of one or more acrylate copolymers, about 2% to about 5% one or more emollients, about 0.5% to about 3.5% one or more silicone elastomer thickening agents and about 1 % to about 4% one or more sodium acryiate-sodium acryloyidSmethy! taurate copolymer-based thickening agents.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, about 2.5% of one or more acrylate copolymers, about 3.5% one or more emollients, about 2% one or more silicone elastomer thickening agents and about 2.5% one or more sodium a yiate-sodium acryioy!dimethyi iauraie copolymer-based thickening agents.
  • a composition disclosed herein comprises a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, one or more film formers, and one or more emollients.
  • a composition is a body wash, a shampoo, an after-shower body lotion, a conditioner, a soap, a gel, a hand sanitizer, a cream, a spray, a mouse, a lotion, an ointment, a make-up product, a lip balm, a hair spray product, an arachnid/insect repellent or a medicinal product.
  • a moisturizing agent comprises amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, glucose, glycerin, glycerol polymers, glycol, 1 ,2,6- hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factor, PEG-15 butanediol, polyglyceryl sorbitol, saccharide isomerate, salts of pyrrolidone carboxylic acid, potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol.
  • a composition disclosed herein comprises about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 19% to about 31 % of a film former and about 6% to about 18% of one or more emollients. In other aspects of this embodiment, a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 21 % to about 29% of a film former and about 8% to about 16% of one or more emollients.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 22% to about 28% of a film former and about 9% to about 15% of one or more emollients.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 24% to about 26% of a film former and about 1 1 % to about 13% of one or more emollients.
  • a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 25% of a film former and about 12% of one or more emollients.
  • a composition disclosed herein comprises about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 19% to about 31 % of a film former and about 6% to about 18% of one or more emollients. In other aspects of this embodiment, a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 21 % to about 29% of a film former and about 8% to about 16% of one or more emollients.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 22% to about 28% of a film former and about 9% to about 15% of one or more emollients. In still other aspects of this embodiment, a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 24% to about 26% of a film former and about 1 1 % to about 13% of one or more emollients.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 25% of a film former and about 12% of one or more emollients.
  • a composition disclosed herein comprises a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, one or more polyquaterniums, and one or more soap bases.
  • a composition disclosed herein comprises about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, and a soap base.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.25% to about 8% of one or more polyquaterniums, and a soap base. In yet other aspects of this embodiment, a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% to about 5% of one or more polyquaterniums, and a soap base.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 1 % to about 3% of one or more polyquaterniums, and a soap base. In other aspects of this embodiment, a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2% of one or more polyquaterniums, and a soap base.
  • a composition disclosed herein comprises about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, and a soap base. In other aspects of this embodiment, a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.25% to about 8% of one or more polyquaterniums, and a soap base.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.5% to about 5% of one or more polyquaterniums, and a soap base. In still other aspects of this embodiment, a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 1 % to about 3% of one or more polyquaterniums, and a soap base.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2% of one or more polyquaterniums, and a soap base.
  • a composition disclosed herein further comprises additional surfactants.
  • additional surfactants include additional cationic surfactants, anionic surfactants, non-ionic surfactants, zwitterionic surfactants, amphoteric surfactants, or any combination thereof.
  • a composition disclosed herein comprises a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, one or more polyquaterniums, one or more anionic surfactants, and one or more amphoteric surfactants.
  • a composition is a body wash, a shampoo, an after-shower body lotion, a conditioner, a soap, a gel, a hand sanitizer, a cream, a spray, a mouse, a lotion, an ointment, a make-up product, a lip balm, a hair spray product, an arachnid/insect repellent or a medicinal product.
  • a moisturizing agent comprises amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, glucose, glycerin, glycerol polymers, glycol, 1 ,2,6-hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factor, PEG-15 butanediol, polyglyceryl sorbitol, saccharide isomerate, salts of pyrrolidone carboxylic acid, potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol.
  • a composition disclosed herein about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, about 0.5% to about 15% one or more anionic surfactants, and about 0.1 % to about 9% one or more amphoteric surfactants.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.2% to about 8% of one or more polyquaterniums, about 2% to about 12% one or more anionic surfactants, and about 0.25% to about 7% one or more amphoteric surfactants.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol- gel encapsulate comprising one or more moisturizing agents, about 0.4% to about 6% of one or more polyquaterniums, about 4% to about 10% one or more anionic surfactants, and about 0.5% to about 5% one or more amphoteric surfactants.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.6% to about 5% of one or more polyquaterniums, about 6% to about 8% one or more anionic surfactants, and about 2% to about 4% one or more amphoteric surfactants.
  • a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, about 7% one or more anionic surfactants, and about 3% one or more amphoteric surfactants.
  • a composition disclosed herein about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, about 0.5% to about 15% one or more anionic surfactants, and about 0.1 % to about 9% one or more amphoteric surfactants.
  • a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.2% to about 8% of one or more polyquaterniums, about 2% to about 12% one or more anionic surfactants, and about 0.25% to about 7% one or more amphoteric surfactants.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.4% to about 6% of one or more polyquaterniums, about 4% to about 10% one or more anionic surfactants, and about 0.5% to about 5% one or more amphoteric surfactants.
  • a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.6% to about 5% of one or more polyquaterniums, about 6% to about 8% one or more anionic surfactants, and about 2% to about 4% one or more amphoteric surfactants.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, about 7% one or more anionic surfactants, and about 3% one or more amphoteric surfactants.
  • a composition disclosed herein comprises a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, one or more polyquaterniums, one or more sulfate surfactants, and one or more betaine surfactants.
  • a composition is a body wash, a shampoo, an after-shower body lotion, a conditioner, a soap, a gel, a hand sanitizer, a cream, a spray, a mouse, a lotion, an ointment, a make-up product, a lip balm, a hair spray product, an arachnid/insect repellent or a medicinal product.
  • a moisturizing agent comprises amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, glucose, glycerin, glycerol polymers, glycol, 1 ,2,6-hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factor, PEG-15 butanediol, polyglyceryl sorbitol, saccharide isomerate, salts of pyrrolidone carboxylic acid, potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol.
  • a composition disclosed herein about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, about 0.5% to about 15% one or more sulfate surfactants, and about 0.1 % to about 9% one or more betaine surfactants.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.2% to about 8% of one or more polyquaterniums, about 2% to about 12% one or more sulfate surfactants, and about 0.25% to about 7% one or more betaine surfactants.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol- gel encapsulate comprising one or more moisturizing agents, about 0.4% to about 6% of one or more polyquaterniums, about 4% to about 10% one or more sulfate surfactants, and about 0.5% to about 5% one or more betaine surfactants.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.6% to about 5% of one or more polyquaterniums, about 6% to about 8% one or more sulfate surfactants, and about 2% to about 4% one or more betaine surfactants.
  • a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, about 7% one or more sulfate surfactants, and about 3% one or more betaine surfactants.
  • a composition disclosed herein comprises a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, one or more polyquaterniums, one or more sulfate surfactants, and one or more betaine surfactants.
  • a composition is a body wash, a shampoo, an after-shower body lotion, a conditioner, a soap, a gel, a hand sanitizer, a cream, a spray, a mouse, a lotion, an ointment, a make-up product, a lip balm, a hair spray product, an arachnid/insect repellent or a medicinal product.
  • a moisturizing agent comprises amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, glucose, glycerin, glycerol polymers, glycol, 1 ,2,6-hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factor, PEG-15 butanediol, polyglyceryl sorbitol, saccharide isomerate, salts of pyrrolidone carboxylic acid, potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol.
  • a composition disclosed herein about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.1 % to about 10% of one or more polyquaterniums, about 0.5% to about 15% one or more sulfate surfactants, and about 0.1 % to about 9% one or more betaine surfactants.
  • a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.2% to about 8% of one or more polyquaterniums, about 2% to about 12% one or more sulfate surfactants, and about 0.25% to about 7% one or more betaine surfactants.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.4% to about 6% of one or more polyquaterniums, about 4% to about 10% one or more sulfate surfactants, and about 0.5% to about 5% one or more betaine surfactants.
  • a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 0.6% to about 5% of one or more polyquaterniums, about 6% to about 8% one or more sulfate surfactants, and about 2% to about 4% one or more betaine surfactants.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 2.5% of one or more polyquaterniums, about 7% one or more sulfate surfactants, and about 3% one or more betaine surfactants.
  • a composition disclosed herein comprises a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, one or more polymers, one or more film formers and one or more fragrances.
  • a composition is a body wash, a shampoo, an after-shower body lotion, a conditioner, a soap, a gel, a hand sanitizer, a cream, a spray, a mouse, a lotion, an ointment, a make-up product, a lip balm, a hair spray product, an arachnid/insect repellent or a medicinal product.
  • a moisturizing agent comprises amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, glucose, glycerin, glycerol polymers, glycol, 1 ,2,6-hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factor, PEG-15 butanediol, polyglyceryl sorbitol, saccharide isomerate, salts of pyrrolidone carboxylic acid, potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol.
  • a composition disclosed herein comprises about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 1 % to about 10% of one or more polymers, about 0.25% to about 8% of one or more film formers and about 0.25% to about 8% one or more fragrances.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 3% to about 9% of one or more polymers, about 0.5% to about 6% of one or more film formers and about 0.5% to about 6% one or more fragrances.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 4% to about 8% of one or more polymers, about 1 % to about 5% of one or more film formers and about 1 % to about 5% one or more fragrances.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 5% to about 7% of one or more polymers, about 2% to about 4% of one or more film formers and about 2% to about 4% one or more fragrances.
  • a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 6% of one or more polymers, about 3% of one or more film formers and about 3% one or more fragrances.
  • a composition disclosed herein comprises about 0.1 % to about 20% of a cellulose encapsulate and/or of a more sol-gel encapsulate comprising one or more moisturizing agents, about 1 % to about 10% of one or more polymers, about 0.25% to about 8% of one or more film formers and about 0.25% to about 8% one or more fragrances.
  • a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 3% to about 9% of one or more polymers, about 0.5% to about 6% of one or more film formers and about 0.5% to about 6% one or more fragrances.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 4% to about 8% of one or more polymers, about 1 % to about 5% of one or more film formers and about 1 % to about 5% one or more fragrances.
  • a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 5% to about 7% of one or more polymers, about 2% to about 4% of one or more film formers and about 2% to about 4% one or more fragrances.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 6% of one or more polymers, about 3% of one or more film formers and about 3% one or more fragrances.
  • a composition disclosed herein comprises about 0.1 % to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 14% to about 26% one or more plant oils, about 1 % to 10% of a polymer, about 0.25% to about 8% of a film former and about 0.1 % to about 6% fragrance.
  • a composition disclosed herein comprises about 0.5% to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 16% to about 24% one or more plant oils, about 3% to 9% of a polymer, about 0.5% to about 6% of a film former and about 0.2% to about 5% fragrance.
  • a composition disclosed herein comprises about 1 % to about 8% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 17% to about 23% one or more plant oils, about 4% to 8% of a polymer, about 1 % to about 5% of a film former and about 0.3% to about 4% fragrance.
  • a composition disclosed herein comprises about 3% to about 5% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 19% to about 21 % one or more plant oils, about 5% to 7% of a polymer, about 2% to about 4% of a film former and about 0.5% to about 2% fragrance.
  • a composition disclosed herein comprises about 4% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 20% one or more plant oils, about 6% of a polymer, about 3% of a film former and about 1 % fragrance.
  • a composition disclosed herein comprises about 0.1 % to about 20% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 14% to about 26% one or more plant oils, about 1 % to 10% of a polymer, about 0.25% to about 8% of a film former and about 0.1 % to about 6% fragrance.
  • a composition disclosed herein comprises about 0.5% to about 15% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 16% to about 24% one or more plant oils, about 3% to 9% of a polymer, about 0.5% to about 6% of a film former and about 0.2% to about 5% fragrance.
  • a composition disclosed herein comprises about 1 % to about 10% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 17% to about 23% one or more plant oils, about 4% to 8% of a polymer, about 1 % to about 5% of a film former and about 0.3% to about 4% fragrance.
  • a composition disclosed herein comprises about 5% to about 7% of a cellulose encapsulate and/or of a sol- gel encapsulate comprising one or more moisturizing agents, about 19% to about 21 % one or more plant oils, about 5% to 7% of a polymer, about 2% to about 4% of a film former and about 0.5% to about 2% fragrance.
  • a composition disclosed herein comprises about 6% of a cellulose encapsulate and/or of a sol-gel encapsulate comprising one or more moisturizing agents, about 20% one or more plant oils, about 6% of a polymer, about 3% of a film former and about 1 % fragrance.
  • application of a composition disclosed herein can occur during washing in a suitable or effective amount, with application over part or the whole body.
  • a shampoo or conditioner, gel, soap, hand sanitizer, cream may be applied to hair, though in an embodiment, the shampoo combination product may be rinsed over part or the whole body, with a composition adhering to the skin and hair.
  • a selected amount of a combination product may be applied directly to the skin, for instance, without limitation, a lotion, spray or bodywash or may be used through intermediate application to a washcloth, pad, sponge, or other applicator.
  • dirt and sloughed-off skin may be washed away by rinsing with water leaving behind one or more of the active agents, and in an embodiment, without limitation, an active agent encapsulated in a cellulose derived capsule.
  • a composition disclosed herein is also useful in the treatment of a skin condition.
  • a skin condition includes, without limitation, Seborrheic dermatitis, eczema, xerosis, infestation, dyschromia, keratosis pilaris, acne, anti-aging, sensitive skin, ephilidies, solar lentigines, photo sensitive disease, skin cancer, melisma, autoimmune disorder, alopecia, fungal, bacterial, and viral infections, protect colored or treated hair, bromhidrosis, malodor, dandruff, wound healing, arachnid/insect repellent, pet shampoo/skin care, lindane or similar conditions.
  • composition that is encapsulated in a cellulose derived capsule and/or a sol- gel capsule are used in paints.
  • a paint including an encapsulated composition includes one or more additional agents, including, without limitation, HALS.
  • a composition that is encapsulated in a cellulose derived capsule and/or a sol- gel capsule are used in products used by the military, police or other governmental or non-governmental force.
  • a product used by the by the military, police or other governmental or nongovernmental force includes, without limitation, sunscreen, paint, clothes, weapons, including, without limitation, weapons containing composite or other synthetic parts, and other by the military, police or other governmental or non-governmental force products.
  • a composition that is encapsulated in a cellulose derived capsule and/or a sol-gel capsule used for by the military, police or other governmental or non-governmental force includes a reflective agent and/or an agent capable of preventing the detection of infrared radiation by an individual or equipment.
  • a composition disclosed herein can be applied once per day, applied two, three, four or more times per day, applied every other day or applied about 10, 8, 7, 6, 5, 4, 3, 2 or 1 time per week.
  • the present invention discloses that a composition can be applied to wet skin and/or hair or applied to dry skin and/or hair.
  • a composition comprising one or more flexible encapsulates comprising one or more moisturizing agents and/or one or more flexible encapsulates comprising one or more other agents.
  • composition of embodiment 1 wherein the one or more flexible encapsulates are in an amount of about 0.1 % to about 20%, about 0.1 % to about 15%, about 0.5% to about 15%, about 0.75% to about 12%, about 0.75% to about 10%, about 1 % to about 10%, about 1 % to about 8%, about 2% to about 7%, about 5% to about 7%, or about 6% by weight of the total composition
  • composition of embodiment 1 wherein the one or more flexible encapsulates are in an amount of about 0.1 % to about 20%, about 0.1 % to about 15%, about 0.5% to about 15%, about 0.75% to about 12%, about 0.75% to about 10%, about 1 % to about 10%, about 1 % to about 8%, about 2% to about 7%, about 3% to about 5% or about 4% by weight of the total composition
  • composition of embodiment 1 wherein the one or more flexible encapsulates are in an amount of about 2% to about 40%, about 3% to about 38%, about 4% to about 36%, about 5% to about 36%, about 6% to about 34%, about 8% to about 32%, about 10% to about 30%, about 12% to about 28%, about 14% to about 26%, about 16% to about 24%, or about 18% to about 22%, by weight of the total composition
  • composition of any one of embodiments 1 -4, wherein the one or more flexible encapsulates comprises a first moisturizing agent and a second moisturizing agent.
  • composition of any one of embodiments 5-7 wherein the first moisturizing agent is in an amount of about 1 % to about 5% and the second moisturizing agent is in an amount of about 95% to about 99%, or wherein the first moisturizing agent is in an amount of about 6% to about 10% and the second moisturizing agent is in an amount of about 90% to about 94%, or wherein the first moisturizing agent is in an amount of about 1 1 % to about 15% and the second moisturizing agent is in an amount of about 85% to about 89%, or wherein the first moisturizing agent is in an amount of about 16% to about 20% and the second moisturizing agent is in an amount of about 80% to about 84%, or wherein the first moisturizing agent is in an amount of about 21 % to about 25% and the second moisturizing agent is in an amount of about 75% to about 79%, or wherein the first moisturizing agent is in an amount of about 26% to about 30% and the second moisturizing agent is in an amount of about 70% to about 74%, or
  • composition of any one of embodiments 1 -9, further comprising one or more moisturizing agents not encapsulated comprising one or more moisturizing agents not encapsulated.
  • the one or more moisturizing agents include amino acids, chondroitin sulf
  • composition comprising one or more flexible encapsulates comprising one or more agents.
  • the one or more agents includes a sunscreen agent, an analgesic agent, an aesthetic agent, an anti-acne agent, an anti-allergenic agent, an anti-cellulite agent, an anti-inflammatory agent, an antioxidant, an anti-pruritic agent, an anti-skin aging agent, an anti-skin wrinkling agent, an anti-microbial agent, an anti-viral agent, a jellyfish repellent agent, a chelating agent, a deodorant, a dye, an essential oil, a hair growth promoter, a hair growth inhibitor, a hair bleaching agent, an anti-lice agent, an arachnid/insect repellent, a lipid, a medicinal agent, a moisturizing agent, a preservative, a silicone containing compound, a liquid hydrocarbon, a fragrance, a camouflage agent, a colorant, soothing agent, skin whitening agent, a skin nourishing agent, a structuring agent, a sunscreen agent, a
  • composition of embodiment 12 or 13, wherein the one or more flexible encapsulates are in an amount of about 0.1 % to about 20%, about 0.1 % to about 15%, about 0.5% to about 15%, about 0.75% to about 12%, about 0.75% to about 10%, about 1 % to about 10%, about 1 % to about 8%, about 2% to about 7%, about 5% to about 7%, or about 6% by weight of the total composition
  • the composition of embodiment 12 or 13, wherein the one or more flexible encapsulates are in an amount of about 0.1 % to about 20%, about 0.1 % to about 15%, about 0.5% to about 15%, about 0.75% to about 12%, about 0.75% to about 10%, about 1 % to about 10%, about 1 % to about 8%, about 2% to about 7%, about 3% to about 5% or about 4% by weight of the total composition
  • the composition of embodiment 12 or 13, wherein the one or more flexible encapsulates are in an amount of about 2% to about 40%, about 3% to about 3
  • composition of any one of embodiments 12-16, wherein the one or more flexible encapsulates comprise one or more flexible cellulose derived encapsulates, one or more sol-gel encapsulates, or a combination of both.
  • composition of any one of embodiments 1 -17 wherein the composition is a body wash, a shampoo, an after-shower body lotion, a conditioner, a soap, a gel, a hand sanitizer, a cream, a spray, a mouse, a lotion, an ointment, a make-up product, a lip balm, a hair spray product, an arachnid/insect repellent or a medicinal product.
  • composition of any one of embodiments 1 -18 further comprising one or more polyquaterniums, one or more surfactants, one or more film formers, one or more emollients, one or more thickening agents, one or more soap bases, one or more polymers, one or more fragrances, or any combination thereof.
  • composition of any one of embodiments 19-23, wherein the one or more polyquaterniums include polyquaternium-1 , polyquaternium-2, polyquaternium-4 (CELQUAT L-200), polyquaternium-5, polyquaternium-6, polyquaternium-7, polyquaternium-10, polyquaternium-1 1 , polyquaternium-15, polyquaternium-16, polyquaternium-22, polyquaternium-28, polyquaternium-32, polyquaternium-37, polyquaternium-39, polyquaternium-40, polyquaternium-41 , polyquaternium-42, polyquaternium-44, polyquaternium-45, polyquaternium-46, polyquaternium-47, polyquaternium-64 or any combination thereof.
  • the one or more polyquaterniums include polyquaternium-1 , polyquaternium-2, polyquaternium-4 (CELQUAT L-200), polyquaternium-5, polyquaternium-6, polyquaternium-7, polyquaternium-10, polyquatern
  • composition of any one of embodiments 19-25 wherein the one or more surfactant are present in an amount of about 2% to about 18%, about 3% to about 15%, about 4% to about 13%, about 5% to about 12% or about 6% to about 1 1 % by weight of the total composition.
  • composition of any one of embodiments 19-29 wherein the one or more surfactants include one or more cationic surfactants, one or more anionic surfactants, one or more non-ionic surfactants, one or more zwitterionic surfactants, one or more amphoteric surfactants, or any combination thereof
  • the one or more surfactants include one or more anionic surfactants present in an amount of about 0.5% to about 15%, about 2% to about 12%, about 4% to about 10%, about 6% to about 8% or about 7% by weight of the total composition.
  • the one or more anionic surfactants include one or more sulfated monoglyceride surfactants, one or more olefin sulfonate surfactants, one or more alkylbenzene sulfonate surfactants, one or more alkane sulfonate surfactants, one or more alkyl sulfosuccinate surfactants, one or more acyl isethionate surfactants or any combination thereof.
  • composition of embodiment 33 wherein the one or more alkyl sulfosuccinate surfactants include disodium N-octadecylsulfosuccinamate, diammonium lauryl sulfosuccinate, disodium laureth sulfosuccinate, tetrasodium N-(1 ,2-dicarboxyethyl)-N-octadecylsulfosuccinate, diamyl ester of sodium sulfosuccinic acid, dihexyl ester of sodium sulfosuccinic acid and dioctyl esters of sodium sulfosuccinic acid; sodium dodecyl sulfate (or sodium lauryl sulfate), sodium laureth sulfate, ammonium lauryl sulfate, or any combination thereof.
  • the one or more alkyl sulfosuccinate surfactants include diso
  • composition of embodiment 33 wherein the one or more acyl isethionate surfactants include an alkylglyceryl ether sulfonate, a sodium cocoglyceryl ether sulfonate, a sulfonated fatty acid, a sulfonated methyl ester, an acyl glutamate, an alkanoyl sarcosinate, an alkyl ether carboxylate, an acyl lactylate, a carboxylate, a saponified soap, or any combination thereof.
  • composition of embodiment 33 wherein the one or more acyl isethionate surfactants ammonium cocoyl isethionate, sodium cocoyl isethionate, sodium lauroyl isethionate, sodium lauroyl sarcosinate, lauroyl sarcosine, sodium cocoyl sarcosinate, ammonium lauroyl sarcosinate, sodium laureth carboxylate, sodium cocoyl lactylate, sodium lauroyl carboxylate, sodium cocoyl carboxylate, ammonium lauroyl carboxylate, sodium laurate, sodium myristate, sodium palmitate, sodium stearate, sodium tallowate, cocoate or any combination thereof.
  • composition of any one of embodiments 37-39, wherein the one or more amphoteric surfactants include one or more betaines, one or more sultaines, one or more hydroxysultaines, one or more alkyliminoacetates, one or more iminodialkanoates, one or more aminoalkanoates or any combination thereof.
  • composition of embodiment 40 wherein the one or more betaines include coco dimethyl carboxymethyl betaine, lauryl dimethyl carboxymethyl betaine, lauryl dimethyl a-carboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, cetyl dimethyl betaine, lauryl bis-(2-hydroxyethyl) carboxymethyl betaine, oleyl dimethyl gamma-carboxypropyl betaine, lauryl bis-(2-hydroxypropyl)a- carboxyethyl betaine, coco dimethyl sulfopropyl betaine, lauryl dimethyl sulfoethyl betaine, lauryl bis- (2-hydroxyethyl) sulfopropyl betaine, oleyl betaine, cocamidopropyl betaine, an amidobetaine, an amidosulfobetaine or any combination thereof.
  • composition of any one of embodiments 19-41 wherein the one or more surfactants include one or more acyl taurate surfactants present in an amount of about 0.1 % to about 5%, about 0.25% to about 4%, about 0.5% to about 3%, about 0.75% to about 2.5% or about 1 % to about 2% by weight of the total composition.
  • the one or more surfactants include one or more acyl taurate surfactants present in an amount of about 0.1 % to about 5%, about 0.25% to about 4%, about 0.5% to about 3%, about 0.75% to about 2.5% or about 1 % to about 2% by weight of the total composition.
  • composition of embodiment 42 wherein the one or more acyl taurate surfactants include sodium methyl cocoyl taurate and sodium methyl oleoyl taurate, taurine, a N-alkyltaurine or any combination thereof.
  • composition of any one of embodiments 19-48, wherein the one or more film formers comprising, consisting essentially of or consisting of petrolatum, dimethicone, stearamidopropyl dimethylamine, stearate and tocopheryl acetate.
  • composition of embodiment 56 wherein one or more silicone elastomer thickening agents are in an amount of about 0.1 % to about 9%, about 0.2% to about 7%, about 0.25% to about 5%, about 0.5% to about 3.5%, or about 2% of the total weight of the composition.
  • composition of embodiment 56 or 57, wherein the one or more silicone elastomer thickening agents include a dimethicone-vinyldimethyl trimethylsiloxysilicate-dimethicone crosspolymer.
  • composition of any one of embodiments 56-59, wherein the one or more sodium aeryiate-sodium acryioyidimethyi taurate copoiymer-based thickening agents include an acfyiaie-sodium aciyioyidimethy! taurate copoiymer-based thickening agent comprising isohexadecane and polysorbate 80.
  • composition of any one of embodiments 19-61 wherein the one or more polymers are present in an amount of about 1 % to about 10%, about 3% to about 9%, about 4% to about 8%, about 5% to about 7% or about 6% by weight of the total composition.
  • composition of claim 66 wherein the one or more other agents including a sunscreen agent, an analgesic agent, an aesthetic agent, an anti-acne agent, an anti-allergenic agent, an anti-cellulite agent, an anti-inflammatory agent, an antioxidant, an anti-pruritic agent, an anti-skin aging agent, an anti-skin wrinkling agent, an anti-microbial agent, an anti-viral agent, a jellyfish repellent agent, a chelating agent, a deodorant, a dye, an essential oil, a hair growth promoter, a hair growth inhibitor, a hair bleaching agent, an anti-lice agent, an arachnid/insect repellent, a lipid, a medicinal agent, a moisturizing agent, a preservative, a silicone containing compound, a liquid hydrocarbon, a fragrance, a camouflage agent, a colorant, soothing agent, skin whitening agent, a skin nourishing agent, a structuring agent,
  • Sunscreen body wash compositions disclosed herein were tested to determine their SPF value using the static, rinse/lather/rinse/rub and/or water immersion (40 or 80 minute) assays using the methods described in FDA Final Monograph, "Labelling and Effectiveness Testing; Sunscreen Drug Products for Over-the Counter Human Use", Final Rule, 21 C.F.R. ⁇ 201 and 310.
  • a 50 cm 2 square area on the back of an individual (application site) was wetted with 10 mL of water delivered with a syringe.
  • the test sunscreen composition was then applied to the application site in amounts as specified in the FDA monograph.
  • the applied composition was allowed to dry for 15 minutes and then exposed to a fixed dose of UV radiation having a continuous emission spectrum from 290 nm to 400 nm with a limit of 1 ,500 W/m 2 using a solar simulator as specified in the FDA monograph.
  • the applied composition was worked into a lather for two minutes and then the application site was rinsed for two minutes with 20 mL water, pat dried and then rubbed using moderate pressure for 20 seconds. The application site was then exposed to a fixed dose of UV radiation having a continuous emission spectrum from 290 nm to 400 nm with a limit of 1 ,500 W/m 2 using a solar simulator as specified in the FDA monograph.
  • the applied composition was allowed to dry for 15 minutes and then the application site immersed into a whirlpool bath for either 40 or 80 minutes.
  • the application site was then exposed to a fixed dose of UV radiation having a continuous emission spectrum from 290 nm to 400 nm with a limit of 1 ,500 W/m 2 using a solar simulator as specified in the FDA monograph.
  • Table 1 shows the test results of a sunscreen body wash composition disclosed herein comprises a cellulose encapsulate comprising a broad-spectrum UVA/UVB sunscreen active agent and a UVA sunscreen active agent, a cellulose encapsulate comprising a UVB sunscreen active agent, a polyquaternium, and one or more surfactants.
  • a sunscreen body wash composition comprising about 1 1 % of a cellulose encapsulate including a mixture of about 65% of an octocrylene and about 35% of avobenzone, about 8% of a cellulose encapsulate comprising octinoxate, about 2.5% of a polyquaternium, 10, about 3.5% sodium laureth sulfate, about 3.5% sodium lauryl sulfate and about 2.8% cocamido propylbetaine was tested.
  • the results indicate that the disclosed sunscreen body wash composition had an average SPF value of 38.07 based on the static assay (Table 1). Interestingly, even after the rinse/lather/rinse/rub assay the average SPF value was still over 33 which represents only a 13% loss in SPF protection after a modified applied water method (Table 1).
  • Label SPF 16 36 31 a 1 is Intensity of Light Source.
  • MED 200 J/m 2 -eff.
  • Tables 2 and 3 show similar results.
  • the sunscreen body wash compositions exhibited an average SPF value of 34.5 based on the static assay (Tables 2 and 3). However, even after an 80- minute water immersion assay, the UV radiation protective capabilities of these compositions were still maintained to an average SPF value of 34.5 (Table 2) and 32.25 (Tables 2 and 3). These results show that the disclose sunscreen body wash compositions demonstrate a significant increase in UV radiation protection and very good water-resistant properties.
  • a I is Intensity of Light Source.
  • MED 200 J/m 2 -eff.
  • a I is Intensity of Light Source.
  • MED 200 J/m 2 -eff.
  • Table 4 shows the test results of a sunscreen body wash composition disclosed herein comprises a cellulose encapsulate comprising a broad-spectrum UVA/UVB sunscreen active agent and a UVA sunscreen active agent, a cellulose encapsulate comprising a UVB sunscreen active agent, a polyquaternium, and one or more surfactants.
  • a sunscreen body wash composition comprising about 11 % of a cellulose encapsulate including about 65% of an octocrylene and about 35% of avobenzone, about 8% of a cellulose encapsulate comprising octinoxate, about 2.5% of a polyquaternium, 10, about 4% disodium laureth sulfosuccinate, about 1.6% sodium cocoyl isethionate, about 1 .6% cocamidopropyl betaine and about 1.6% sodium methyl cocoyl taurate was tested.
  • the results indicate that the disclosed sunscreen body wash composition had an average SPF value of 36.54 based on the static assay (Table 4). Interestingly, even after the rinse/lather/rinse/rub assay the average SPF value was still over 33 (Table 4).
  • a I is Intensity of Light Source.
  • MED 200 J/m 2 -eff.
  • Tables 5 and 6 show similar results.
  • the sunscreen body wash compositions exhibited an average SPF value of 34.5 based on the static assay (Tables 5 and 6). However, even after an 80- minute water immersion assay, the UV radiation protective capabilities of these compositions were still maintained to an average SPF value of 30.0 (Table 5 and 6). These results show that the disclose sunscreen body wash compositions demonstrate very water-resistant properties.
  • a I is Intensity of Light Source.
  • MED 200 J/m 2 -eff.
  • a I is Intensity of Light Source.
  • MED 200 J/m 2 -eff.
  • Sunscreen lotion compositions disclosed herein were tested to determine their SPF value using the static and water immersion (40 or 80 minute) assays as described in Example 1 .
  • Table 7 shows the test results of a sunscreen lotion composition disclosed herein comprises a cellulose encapsulate comprising a broad-spectrum UVA UVB sunscreen active agent, a UVA sunscreen active agent and a photostabilizing agent, a cellulose encapsulate comprising a UVB sunscreen active agent, a cellulose encapsulate comprising a silicone oil, a cellulose encapsulate comprising a comprising a shea oil, one or more emollients and one or more thickening agents.
  • a sunscreen lotion composition comprising about 0.15% of a cellulose encapsulate comprising a silicone oil, about 0.2% of a cellulose encapsulate comprising a shea oil, about 11 % of a cellulose encapsulate comprising about 63% of an octocrylene, about 35% of avobenzone and about 2% trimethoxy benylidene pentanedione, about 8% of a cellulose encapsulate comprising octinoxate, about 3.5% capryllic capric triglyceride, and about 2% dimethicone-vinyldimethyl trimethylsiloxysilicate-dimethicone crosspolymer and about 2.5% aerylate- sodium acryloyic!imethyi iauraie eopo!ymer-based thickening agent including isohexadecane and polysorbate 80 (DERMACYL ® AFQ) was tested.
  • a I is Intensity of Light Source.
  • MED 200 J/m 2 -eff.
  • Table 8 shows similar results.
  • the disclosed sunscreen lotion composition exhibited an average SPF value of 69.0 based on the static assay (Table 8). However, even after an 80-minute water immersion assay, the UV radiation protective capabilities of this composition were maintained, dropping only to an average SPF value of 52.2 (Table 8). These results indicate that a photostabilizing agent significantly increases the UV radiation protective capabilities of a sunscreen composition, and that this enhanced protective effect appears to be maintained even exposure to water immersion.
  • a I is Intensity of Light Source.
  • MED 200 J/m 2 -eff.
  • Table 9 shows the test results of a sunscreen lotion composition disclosed herein comprises a cellulose encapsulate comprising a broad-spectrum UVA/UVB sunscreen active agent and a UVA sunscreen active agent, a cellulose encapsulate comprising a UVB sunscreen active agent, a cellulose encapsulate comprising a silicone oil, a cellulose encapsulate comprising a comprising a shea oil, a film former, one or more emollients and one or more thickening agents.
  • a sunscreen lotion composition comprising about 0.15% of a cellulose encapsulate comprising a silicone oil, about 0.2% of a cellulose encapsulate comprising a shea oil, about 1 1 % of a cellulose encapsulate comprising about 65% of an octocrylene and about 35% of avobenzone, about 8% of a cellulose encapsulate comprising octinoxate, about 3% of an acrylate copolymer (DERMACRYL ® AQF), about 3.5% capryllic capric triglyceride, and about 2% dimethicone-vinyldimethyl trimethylsiloxysilicate-dimethicone crosspolymer and about 2.5% acryiate-sodium actyloyldimeihyi iaurate copolymer- based thickening agent including isohexadecane and polysorbate 80 (SIMLGEL ® EG) was tested.
  • a I is Intensity of Light Source.
  • MED 200 J/m 2 -eff.
  • Table 10 shows similar results.
  • the disclosed sunscreen lotion composition exhibited an average SPF value of 53.75 based on the static assay (Table 10). However, even after an 80-minute water immersion assay, the UV radiation protective capabilities of this composition were maintained, dropping only to an average SPF value of 43.5 (Table 10). These results indicate that a film former significantly increases the UV radiation protective capabilities of a sunscreen composition, and that this enhanced protective effect appears to be maintained even exposure to water immersion.
  • N 2 2 2 2 a 1 is Intensity of Light Source.
  • MED 200 J/m 2 -eff.
  • Table 1 1 shows the test results of a sunscreen lotion composition disclosed herein comprises a cellulose encapsulate comprising a broad-spectrum UVA/UVB sunscreen active agent, a UVA sunscreen active agent and a photostabilizing agent, a cellulose encapsulate comprising a UVB sunscreen active agent, a cellulose encapsulate comprising a silicone oil, a cellulose encapsulate comprising a comprising a shea oil, a film former, one or more emollients and one or more thickening agents.
  • a sunscreen lotion composition comprising about 0.15% of a cellulose encapsulate comprising a silicone oil, about 0.2% of a cellulose encapsulate comprising a shea oil, about 8% of a cellulose encapsulate comprising about 63% of an octocrylene, about 35% of avobenzone and about 2% trimethoxy benylidene pentanedione, about 6% of a cellulose encapsulate comprising octinoxate, about 3% of an acrylate copolymer (DERMACRYL ® AQF), about 3.5% capryllic capric triglyceride, and about 2% dimethicone-vinyldimethyl trimethylsiloxysilicate-dimethicone crosspolymer and about 2.5% acry!aie- sodium acr ioyidimelhyS ta urate copoiymer-based thickening agent including isohexade
  • a I is Intensity of Light Source.
  • MED 200 J/m 2 -eff.
  • Sunscreen soap compositions disclosed herein were tested to determine their SPF value using the static and water immersion (40 minute) assays as described in Example 1 , except that prior to application, the sunscreen soap composition was dissolve in water, such that it was diluted to a 50% concentration and the prepared solution was then delivered to the test site at a dosage of 4.0 mg/cm 2 .
  • Table 12 shows the test results of a sunscreen soap composition disclosed herein comprises a cellulose encapsulate comprising a broad-spectrum UVA/UVB sunscreen active agent and a UVA sunscreen active agent, a cellulose encapsulate comprising a UVB sunscreen active agent, a polyquaternium mixed into a soap base.
  • a sunscreen soap composition comprising about 8% of a cellulose encapsulate comprising about 65% of an octocrylene and about 35% of avobenzone, about 6% of a cellulose encapsulate comprising octinoxate and about 2% of polyquaternium 16 mixed into a soap base was tested.
  • the results indicate that the disclosed sunscreen lotion composition had an average SPF value of 25.3 based on the static assay (Table 12). However, after a 40-minute water immersion assay, the UV radiation protective capabilities of this composition were not maintained (Table 12).
  • a I is Intensity of Light Source.
  • MED 200 J/m 2 -eff.
  • Table 13 shows the test results of a sunscreen after-shower body lotion composition disclosed herein comprises a cellulose encapsulate comprising a broad-spectrum UVA/UVB sunscreen active agent and a UVA sunscreen active agent, a cellulose encapsulate comprising a UVB sunscreen active agent, a cellulose encapsulate comprising a silicone oil, a cellulose encapsulate comprising shea oil, a polyquaternium, a film former and one or more surfactants.
  • a sunscreen after-shower body lotion composition comprising about 11 % of a cellulose encapsulate comprising about 65% of an octocrylene and about 35% of avobenzone, about 8% of a cellulose encapsulate comprising octinoxate, about 0.15% of a cellulose encapsulate comprising a silicone oil, about 0.2% of a cellulose encapsulate comprising a shea oil, about 2.5% of polyquaternium 4 or polyquaternium 10, about 2.5% of an acrylate copolymer (DERMACRYL ® AQF), about 2.0% acryiaie-sodium acryloyldimethyl taurate copoiymer-based thickening agent including isohexadecane and polysorbate 80 (SIMLGEL ® EG) and about 1 .5% cocamidopropyl betaine was tested. The results indicate that the disclosed sunscreen after-shower body lotion composition had an average SPF value of 46 based
  • Sunscreen lotion compositions disclosed herein were tested to determine their SPF value using the static assay as described in Example 1 .
  • Table 14 shows the test results of a sunscreen lotion composition disclosed herein comprises a cellulose encapsulate comprising a broad-spectrum UVA/UVB sunscreen active agent and a UVA sunscreen active agent, a cellulose encapsulate comprising a UVB sunscreen active agent, a polyquaternium and a film former.
  • a sunscreen lotion composition comprising about 13.5% of a cellulose encapsulate comprising about 65% of an octocrylene and about 35% of avobenzone, about 13.5% of a cellulose encapsulate comprising octinoxate, about 0.7% of polyquaternium 4 and about 2% of an acrylate copolymer (DERMACRYL ® AQF) was tested.
  • the results indicate that the disclosed sunscreen lotion composition had an average SPF value of 37.05 based on the static assay (Table 14).
  • N 2 2 a 1 is Intensity of Light Source.
  • MED 200 J/m 2 -eff.
  • a sunscreen lotion composition comprising a polyquaternium, a film former and an arachnid/insect repellent.
  • Table 15 shows the test results of a sunscreen lotion composition disclosed herein comprises a cellulose encapsulate comprising a broad-spectrum UVA/UVB sunscreen active agent and a UVA sunscreen active agent, a cellulose encapsulate comprising a UVB sunscreen active agent, a polyquaternium, a film former and an arachnid/insect repellent.
  • a sunscreen lotion composition comprising about 13.5% of a cellulose encapsulate comprising about 65% of an octocrylene and about 35% of avobenzone, about 13.5% of a cellulose encapsulate comprising octinoxate, about 0.7% of polyquaternium 4, about 2% of an acrylate copolymer (DERMACRYL ® AQF) and about 5% citronella was tested.
  • the results indicate that the disclosed sunscreen lotion composition had an average SPF value of 37.05 based on the static assay (Table 15).
  • a sunscreen lip balm composition disclosed herein were tested to determine their SPF value using the static and water immersion (80 minute) assays as described in Example 1 .
  • Table 16 shows the test results of a sunscreen lip balm composition disclosed herein comprises a cellulose encapsulate comprising a broad-spectrum UVA/UVB sunscreen active agent and a UVA sunscreen active agent, a cellulose encapsulate comprising a UVB sunscreen active agent, a polyquaternium and a film former.
  • a sunscreen lip balm composition comprising about 15% of a cellulose encapsulate comprising about 51 % homosalate, about 24% octyl salicylate, about 13% avobenzone, about 6% trimethoxybenzylidene pentanedione (SYNOXYL ® HSS) and about 5% of a polymer, 25% petroleum and 12% cocoa butter was tested.
  • the results indicate that the disclosed sunscreen lip balm composition had an average SPF value of 44.20 based on the static assay (Table 16).
  • the UV radiation protective capabilities of this composition were maintained, dropping only to an average SPF value of 43.60 (Table 16).
  • a I is Intensity of Light Source.
  • MED 200 J/m 2 -eff.
  • testing can be done on a sunscreen lip balm composition
  • a sunscreen lip balm composition comprising about 15% of a cellulose encapsulate comprising about 51 % homosalate, about 24% octyl salicylate, about 13% avobenzone, about 3% ethylhexyl methoxycrylene (SOLASTAY ® S1) and about 3% of a bis- methoxycrylene/octyldodecyl adipic acid/methylpropanediol copolymer (SOLASTAY ® P1), 25% petroleum and 12% cocoa butter. Similar SPF results are expected.
  • testing can be done on a sunscreen lip balm composition
  • a sunscreen lip balm composition comprising about 15% of a cellulose encapsulate comprising about 51 % homosalate, about 24% octyl salicylate, about 13% avobenzone, about 2% trimethoxybenzylidene pentanedione (SYNOXYL ® HSS), about 2% ethylhexyl methoxycrylene (SOLASTAY ® S1) and about 2% of a bis-methoxycrylene/octyldodecyl adipic acid/methylpropanediol copolymer (SOLASTAY ® P1), 25% petroleum and 12% cocoa butter. Similar SPF results are expected.
  • SOLASTAY ® P1 a bis-methoxycrylene/octyldodecyl adipic acid/methylpropanediol copolymer
  • Sunscreen Composition 1 was a commercially available sunscreen formulation that contained 4.5% octylmethoxy cinnamate (unencapsulated or free) and was spiked with 0.2% Nile Red fluorescent dye.
  • Sunscreen Composition 2 (Sun Comp 2) contained flexible cellulose derived capsules containing 4.5% octylmethoxy cinnamate and 0.2% Nile Red fluorescent dye.
  • Each sunscreen composition was then applied to a separate region of the surface of the prepared samples by spreading the composition with a plastic pipet tip to form an even layer with a minimum 5 mm margin of untreated surface at the cut edges,
  • Each skin sample received a total dose of 5 mg/cm 2 of each sunscreen composition.
  • dosing samples were incubated on a 35°C flat surface with the inner sides of the samples kept hydrated with PBS buffer. Data was acquired for incubation times of 30 minutes and 90 minutes for each product type.
  • FIG. 1 indicates that dye penetration into skin is dramatically reduced (70%-80%) in the encapsulated formulation of Sunscreen Composition 2 relative to identically spiked commercial formulation of Sunscreen Composition 1 , reflecting a strong reduction of octylmethoxy cinnamate absorption.
  • no significant change in the overall concentration is observed between 30- and 90-minute time points, reflecting approximately steady-state flux, as the high surface concentration diffuses in to a relatively large volume of skin.
  • FIGs. 3A-C visually shows that the vast majority of the fluorescent dye containing cellulose derived capsules remained on the skin surface (compare 10 pm skin depth photograph of FIG. 3A with 50 pm skin depth photograph of FIG. 3B and 90 pm skin depth photograph of FIG. 3C). For example, at 10 pm the stratum corneum is high reflective and appears bright. However, in deep locations, there is no bright appearance. Quantitation of the fluorescence indicate that very little penetration of the fluorescent dye occurred below 10 pm from the skin surface (FIG. 3D). In comparison to the commercial formulation of Sunscreen Composition 1 , these results indicate that there is an 80% reduction in skin penetration of the florescent dye when using Sunscreen Composition 2.
  • Composition 1 was a sunscreen lotion composition disclosed herein comprising about 0.15% of a cellulose encapsulate comprising a silicone oil, about 0.2% of a cellulose encapsulate comprising a shea oil, about 1 1 % of a cellulose encapsulate comprising about 65% of an octocrylene and about 35% of avobenzone, about 8% of a cellulose encapsulate comprising octinoxate, about 3% of an acrylate copolymer (DERMACRYL ® AQF), about 3.5% capryllic capric triglyceride, and about 2% dimethicone- vinyldimethyl trimethylsiloxysilicate-dimethicone crosspolymer and about 2.5% acryiaie-sodium acryloyldimethyi iaurate cop
  • compositions 2-6 were commercially available sunscreen products having an SPF 50 value. Analysis of all six compositions revealed that to achieve an SPF 50, Composition 1 required about 13% by weight active sunscreen agents in an encapsulated form (FIG. 4). On the other hand, Compositions 2-6 required from about 22% to about 29% by weight active sunscreen agents to achieve a SPF value of 50 (FIG. 4). These results indicate that the sunscreen composition disclosed herein increases the efficacy of a UV absorber by at least 70%.
  • the filter paper is moistened with water and the number and of ticks attached to the bottom of the basket and the location distance from the 4 cm x 4 cm filter paper was assessed during a 10-minute time period at 3 minutes, 5 minutes and 10 minutes.
  • the filter paper is treated by gently applying a roll-on applicator containing the test composition and the number and of ticks attached to the bottom of the basket and the location distance from the 4 cm x 4 cm filter paper was assessed during a 10-minute time period at 3 minutes, 5 minutes and 10 minutes.
  • Test composition 1 10216 is a lotion composition comprising about 14% of a cellulose encapsulate comprising about 94% Lemon Eucalyptus oil and about 6% of a polymer, 20% geraniol, 3% of a film former (DERMACRYL ® E), about 1 % fragrance and about 32% water.
  • the data is shown in Table 17.
  • the test composition shows a significant repellent activity compared to the control.
  • tick repellency testing can be done using Test composition 100316 or Test composition 1 13016Z discussed below.
  • a mosquito cage is set up with 25 female Aedes aegyptl mosquitoes.
  • the top lid of the cage has a 2.5" by 6" opening in the center.
  • a collagen membrane is place over the opening and is used as the test surface because it mimics human skin.
  • a test subject's forearm is then positioned over the opening.
  • Mesh is placed on the top side of the test surface to prevent direct contact of the test surface with the test subject's arm and disposable wood spacers are placed on top of the top cover to elevate the test subject's arm from the test substance and to prevent the mosquitoes from being able to feed on the test subject.
  • Pre-treatment landing and probing numbers were obtained by counting the number of mosquitos that landed and probed the collagen membrane during a 5-minute time period.
  • Treatment landing and probing numbers were obtained as follows: for the control composition, the collagen membrance is moistened with water and landing and probing numbers were obtained by counting the number of mosquitos that landed and probed the treated collagen membrane during a 5 minute time period; for the test compositions, the collagen membrane is treated by gently applying a roll-on applicator containing the test composition and landing and probing numbers were obtained by counting the number of mosquitos that landed and probed the treated collagen membrane during a 5 minute time period.
  • Test composition 100316 is a lotion composition comprising about 20% of a cellulose encapsulate comprising about 47% Lemon Eucalyptus oil, about 47% IR3535 and about 6% of a polymer, 3% of a film former (DERMACRYL ® AQF), about 3% fragrance and about 40% water.
  • Test composition 1 13016Z is a lotion composition comprising about 20% of a cellulose encapsulate comprising about 94% Lemon Eucalyptus oil and about 6% of a polymer, 3% of a film former (DERMACRYL ® AQF), about 1 % fragrance and about 44% water. Landing and probing numbers were collected at 1 hour, 2 hours and 4 hours after treatment of the collagen membrane.
  • the percent landing and probing numbers were calculated by comparing the number of landing and probes during the pre-treatment evaluation to the number of landing and probes during the treatment evaluation at all three time intervals. The data is shown in Table 18. Both test compositions show a significant repellent activity compared to the control. Alternatively, mosquito repellency testing can be done using Test composition 110216 discussed above.
  • arachnid/insect repellency testing can be done on a sunscreen/insect repellent composition
  • a sunscreen/insect repellent composition comprising about 15% of a cellulose encapsulate comprising about 25.5% homosalate, about 12% octyl salicylate, about 6.5% avobenzone, about 1 .5% ethylhexyl methoxycrylene (SOLASTAY ® S1), about 1 .5% of a bis-methoxycrylene/octyldodecyl adipic acid/methylpropanediol copolymer (SOLASTAY ® P1), about 23.5% Lemon Eucalyptus oil, about 23.5% IR3535 and about 3% of a polymer, 3% of a film former (DERMACRYL ® AQF) and about 3% fragrance. Similar SPF and repellency results are expected.
  • arachnid/insect repellency testing can be done on a sunscreen sunscreen/insect repellent composition
  • a sunscreen sunscreen/insect repellent composition comprising about 15% of a cellulose encapsulate comprising about 25.5% homosalate, about 12% octyl salicylate, about 6.5% avobenzone, about 1 .5% trimethoxybenzylidene pentanedione (SYNOXYL ® HSS), about 1.5% ethylhexyl methoxycrylene (SOLASTAY ® S1), about 1 .5% of a bis-methoxycrylene/octyldodecyl adipic acid/methylpropanediol copolymer (SOLASTAY ® P1), about 47% Lemon Eucalyptus oil and about 4.5% of a polymer, 3% of a film former (DERMACRYL ® AQF) and about 1 % fragrance. Similar SPF
  • arachnid/insect repellency testing can be done on a sunscreen sunscreen/insect repellent composition
  • a sunscreen sunscreen/insect repellent composition comprising about 15% of a cellulose encapsulate comprising about 25.5% homosalate, about 12% octyl salicylate, about 6.5% avobenzone, about 1 .5% trimethoxybenzylidene pentanedione (SYNOXYL ® HSS), about 1.5% ethylhexyl methoxycrylene (SOLASTAY ® S1), about 1 .5% of a bis-methoxycrylene/octyldodecyl adipic acid/methylpropanediol copolymer (SOLASTAY ® P1), about 47% Lemon Eucalyptus oil and about 3% of a polymer, 20% geraniol, 3% of a film former (DERMACRYL ® E) and about 1 %
  • a moisturizing agent composition disclosed herein were tested to determine the effect of encapsulation of enhanced skin moositurization.
  • the encapsulated formulation resulted in abou 53%% improvement is skin mositurization whereas the non-excapulated formulation resulted in only a 35.2% improvement. This also represents a 1 .5-fold increase in performance with respect to the encapsulated moisturizing agent.
  • the meaning of the open-ended transitional phrase “comprising” is being defined as encompassing all the specifically recited elements, limitations, steps and/or features as well as any optional, additional unspecified ones.
  • the meaning of the closed-ended transitional phrase “consisting of” is being defined as only including those elements, limitations, steps and/or features specifically recited in the claim whereas the meaning of the closed-ended transitional phrase “consisting essentially of is being defined as only including those elements, limitations, steps and/or features specifically recited in the claim and those elements, limitations, steps and/or features that do not materially affect the basic and novel characteristic(s) of the claimed subject matter.
  • the open-ended transitional phrase “comprising” includes within its meaning, as a limiting case, claimed subject matter specified by the closed-ended transitional phrases “consisting of or “consisting essentially of.”
  • claimed subject matter specified by the closed-ended transitional phrases “consisting of or “consisting essentially of.”
  • embodiments described herein or so claimed with the phrase “comprising” are expressly or inherently unambiguously described, enabled and supported herein for the phrases “consisting essentially of and “consisting of.”

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Abstract

La présente invention concerne des compositions comprenant un ou plusieurs agents d'encapsulation comprenant un ou plusieurs agents et des procédés et des utilisations pour les agents décrits. Une composition selon l'invention peut être incorporée à un nettoyant pour le corps, une lotion pour le corps après la douche, un shampooing, un après-shampooing, un savon, un gel, un désinfectant pour les mains, une crème, un spray, une mousse, une lotion, une pommade, un produit de maquillage, un baume pour les lèvres, un produit de laque pour les cheveux, un produit répulsif contre les arachnides/insectes ou un produit médicinal.
PCT/US2018/017722 2017-02-10 2018-02-10 Compositions contenant une capsule souple avec un principe actif WO2018148614A1 (fr)

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US15/430,416 US10322301B2 (en) 2012-11-06 2017-02-10 Compositions containing a cellulose derived capsule with a sunscreen active agent
USPCT/US2017/017556 2017-02-10
US15/430,416 2017-02-10
PCT/US2017/017556 WO2017139701A1 (fr) 2016-02-10 2017-02-10 Compositions contenant une capsule dérivée de cellulose avec un agent actif d'écran solaire

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US5614217A (en) * 1995-06-07 1997-03-25 R.P. Scherer Corporation Capsule shell formulation to produce brittle capsules
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