WO2018140411A3 - Nanoparticules polymères thérapeutiques pour une expression génique personnalisée - Google Patents
Nanoparticules polymères thérapeutiques pour une expression génique personnalisée Download PDFInfo
- Publication number
- WO2018140411A3 WO2018140411A3 PCT/US2018/014898 US2018014898W WO2018140411A3 WO 2018140411 A3 WO2018140411 A3 WO 2018140411A3 US 2018014898 W US2018014898 W US 2018014898W WO 2018140411 A3 WO2018140411 A3 WO 2018140411A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nanoparticles
- gene expression
- polymeric nanoparticles
- tailored
- therapeutic polymeric
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6939—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being a polysaccharide, e.g. starch, chitosan, chitin, cellulose or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0091—Purification or manufacturing processes for gene therapy compositions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Nanotechnology (AREA)
- Manufacturing & Machinery (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention concerne une composition pour une administration personnalisée de polynucléotide non viral à une cellule comprenant une pluralité de nanoparticules et un polynucléotide fixé à une surface extérieure d'au moins une nanoparticule parmi la pluralité de nanoparticules et des méthodes d'utilisation et de fabrication de ladite composition. Chaque nanoparticule parmi la pluralité de nanoparticules a un polymère cationique naturel ou synthétique réticulé électrostatiquement avec un agent de réticulation électrostatique anionique. Chaque nanoparticule parmi la pluralité de nanoparticules a un potentiel zêta positif, et chaque nanoparticule parmi la pluralité de nanoparticules présente un diamètre situé dans la plage allant de 1 nm à 1 000 nm.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762449884P | 2017-01-24 | 2017-01-24 | |
US62/449,884 | 2017-01-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2018140411A2 WO2018140411A2 (fr) | 2018-08-02 |
WO2018140411A3 true WO2018140411A3 (fr) | 2018-10-18 |
Family
ID=62978628
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2018/014898 WO2018140411A2 (fr) | 2017-01-24 | 2018-01-23 | Nanoparticules polymères thérapeutiques pour une expression génique personnalisée |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2018140411A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021081495A1 (fr) * | 2019-10-25 | 2021-04-29 | The Johns Hopkins University | Nanoparticules polymères pour l'administration intracellulaire de protéines |
CN114317478B (zh) * | 2022-01-05 | 2023-10-20 | 北京化工大学 | 一种蔗糖磷酸化酶的应用及利用其制备2-α-甘油葡萄糖苷的方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100086613A1 (en) * | 2008-10-03 | 2010-04-08 | Chang-Jer Wu | Chitosan vehicle and method for making same |
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2018
- 2018-01-23 WO PCT/US2018/014898 patent/WO2018140411A2/fr active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100086613A1 (en) * | 2008-10-03 | 2010-04-08 | Chang-Jer Wu | Chitosan vehicle and method for making same |
Non-Patent Citations (4)
Title |
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CHEN, L. ET AL.: "Chitosan/beta-lactoglobulin core-shell nanoparticles as nutraceutical carriers", BIOMATERIALS, vol. 26, no. 30, October 2005 (2005-10-01), pages 6041 - 6053, XP055546989 * |
CUI, Z. ET AL.: "Intranasal administration of plasmid DNA-coated nanoparticles results in enhanced immune responses", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 54, 2002, pages 1195 - 1203, XP055546994 * |
KUMAR, A. ET AL.: "Microneedle-mediated transcutaneous immunization with plasmid DNA coated on cationic PLGA nanoparticles", JOURNAL OF CONTROLLED RELEASE, vol. 163, no. 2, October 2012 (2012-10-01), pages 230 - 239, XP055546991 * |
TIYABOONCHAI, W. ET AL.: "Chitosan nanoparticles: a promising system for drug delivery", NARESUAN UNIVERSITY JOURNAL, vol. 11, no. 3, 2013, pages 51 - 66, XP055546997 * |
Also Published As
Publication number | Publication date |
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WO2018140411A2 (fr) | 2018-08-02 |
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