WO2018132639A8 - Methods and kits for the diagnosis and/or prognosis of ocular cicatricial pemphigoid - Google Patents

Methods and kits for the diagnosis and/or prognosis of ocular cicatricial pemphigoid Download PDF

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Publication number
WO2018132639A8
WO2018132639A8 PCT/US2018/013453 US2018013453W WO2018132639A8 WO 2018132639 A8 WO2018132639 A8 WO 2018132639A8 US 2018013453 W US2018013453 W US 2018013453W WO 2018132639 A8 WO2018132639 A8 WO 2018132639A8
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WO
WIPO (PCT)
Prior art keywords
methods
kits
ocp
prognosis
diagnosis
Prior art date
Application number
PCT/US2018/013453
Other languages
French (fr)
Other versions
WO2018132639A1 (en
Inventor
Charles Stephen FOSTER
Razzaque AHMED
Original Assignee
Foster Charles Stephen
Ahmed Razzaque
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Foster Charles Stephen, Ahmed Razzaque filed Critical Foster Charles Stephen
Publication of WO2018132639A1 publication Critical patent/WO2018132639A1/en
Publication of WO2018132639A8 publication Critical patent/WO2018132639A8/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/16—Ophthalmology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Rehabilitation Therapy (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides methods of diagnosing ocular cicatricial pemphigoid (OCP) in a subject, by determining the level or concentration of autoantibodies that bind β4 integrin in a biological sample obtained from the subject. In embodiments, the concentration of anti-β4 integrin autoantibodies is determined using an ELISA. Methods of monitoring the course of OCP, methods of treating OCP, and kits for diagnosing OCP are also provided.
PCT/US2018/013453 2017-01-13 2018-01-12 Methods and kits for the diagnosis and/or prognosis of ocular cicatricial pemphigoid WO2018132639A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762446080P 2017-01-13 2017-01-13
US62/446,080 2017-01-13

Publications (2)

Publication Number Publication Date
WO2018132639A1 WO2018132639A1 (en) 2018-07-19
WO2018132639A8 true WO2018132639A8 (en) 2019-06-27

Family

ID=61226655

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2018/013453 WO2018132639A1 (en) 2017-01-13 2018-01-12 Methods and kits for the diagnosis and/or prognosis of ocular cicatricial pemphigoid

Country Status (1)

Country Link
WO (1) WO2018132639A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
WO1994016101A2 (en) 1993-01-07 1994-07-21 Koester Hubert Dna sequencing by mass spectrometry
WO1994021822A1 (en) 1993-03-19 1994-09-29 Sequenom, Inc. Dna sequencing by mass spectrometry via exonuclease degradation
WO2011160096A2 (en) * 2010-06-17 2011-12-22 Banyan Biomarkers, Inc. Glial fibrillary acidic protein, autoantigens and autoantibodies thereto as biomarkers of neural injury or neurological disorder or condition

Also Published As

Publication number Publication date
WO2018132639A1 (en) 2018-07-19

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