WO2018130036A1

WO2018130036A1 - Multi-sensor cardiopulmonary coupling sleep quality detection system and detection method thereof

Info

Publication number: WO2018130036A1
Application number: PCT/CN2017/115780
Authority: WO
Inventors: 冯雪; 陈毅豪; 陆炳卫
Original assignee: 清华大学
Priority date: 2017-01-16
Filing date: 2017-12-13
Publication date: 2018-07-19
Also published as: CN106859598A

Abstract

A multi-sensor cardiopulmonary coupling sleep quality detection system and a detection method thereof. An ultra-thin flexible strain sensor (1) and an ECG sensor (2) are lightly attached to the body surface of a sleeper without causing any discomfort or sensation of restriction, such that the presence of the sensors cannot be felt during measurement and the impact on the sleeper is reduced to the greatest extent, thus truly reflecting the state of the sleeper when sleeping; the ultra-thin flexible sensors are used to measure breathing and ECG signals and a cardiopulmonary coupling algorithm is used to comprehensively analyse the breathing and ECG signals in order to obtain quantitative index parameters of the sleep quality of the patient and the times of apnoeic characteristics of apnoea syndrome; the signals are transmitted to a mobile terminal using a wireless method; and the volume of the entire system is small, facilitating use in different sleeping scenarios, and being easy to operate, highly accurate, convenient to use, and comfortable.

Description

Multi-sensor cardiopulmonary coupled sleep quality detecting system and detecting method thereof

Technical field

The invention relates to a flexible electronic device technology, in particular to an cardiopulmonary coupled sleep quality detecting system based on an ultra-thin flexible strain and an electrocardiographic sensor and a detecting method thereof.

Background technique

One third of a person's life is spent in sleep. The importance of sleep to people has become more and more important, and the impact of sleep quality and the dangers of sleep diseases are becoming clearer. Apnea syndrome is a sleep disorder in which breathing stops during sleep. The most common cause is obstruction of the upper airway, often ending with loud snoring, body twitching or arm twitching. Up to 98% of patients with sleep apnea will have snoring, usually with complications such as hypertension, myocardial infarction, myocardial hypoxia, and stroke. Even if you have enough time to sleep, you are still very tired and have serious health problems. According to the survey, the incidence of sleep apnea syndrome in foreign countries is 2% to 4%. According to clinical statistics, the incidence rate in China should be 9%. With the improvement of living standards in China, the increase of obesity has been in the past two decades. It shows a trend of increasing year by year. In patients with apnea syndrome, due to recurrent hypoxemia, hypercapnia, neurological dysfunction, catecholamine, endothelin and renin-angiotensin system disorders, endocrine dysfunction and hemodynamic changes, Causes multiple system and multiple system damage, which seriously affects human health, easily complicated by arrhythmia, high blood pressure and even respiratory failure, sudden death. For sleep and respiratory monitoring, the quality of sleep and the risk of apnea syndrome can be effectively judged and assessed. At present, most hospitals use polysomnography to diagnose sleep disorders. Various physiological sensors are used to monitor and record various physiological parameters during sleep. EEG, ECG, ECG, EOG, EMG EMG are recorded and analyzed. Anaesthesia of sleep breathing parameters such as chest-abdominal breathing, snoring, pulse, blood oxygen saturation, pulse wave, respiratory rate, and body position. However, in order to obtain the corresponding signals, the polysomnography monitor needs to arrange many leads at various positions of the human body such as the mouth, nose, jaw, chest, legs, fingers, which will cause great harm to the sleep of the monitored patient. Comfort, the subject's sleep quality is reduced or even can not sleep; at the same time, the polysomnography is large, only suitable for use in hospitals, can not detect the sleep state of patients in different sleep environments.

Xiaomi's millet bracelet measures the movement of the body and upper limbs during sleep by the accelerometer, and uses the time of rest of the limb as the sleep time to further analyze the quality and state of sleep. Although the millet bracelet is simple in equipment, low in cost, and has little influence on the sleep mode, it can only distinguish between sleep state and awake state, and cannot analyze the apnea condition.

Sleepace's Reston Smart Sleep Monitor judges sleep by measuring the heartbeat, breathing, turning over, and leaving the bed by placing the monitor under the sleeper. Although this smart sleep monitor does not require direct contact with the human body, It reduces the impact on sleep conditions, but it is a passive measurement, the measurement data is single, and the apnea cannot be judged.

Summary of the invention

In view of the above problems in the prior art, the present invention proposes a cardiopulmonary coupled sleep quality detecting system based on an ultra-thin flexible strain and an electrocardiographic sensor and a detecting method thereof.

It is an object of the present invention to provide a cardiopulmonary coupled sleep quality detection system based on an ultra-thin flexible strain and electrocardiographic sensor.

The cardiopulmonary coupled sleep quality detecting system based on the ultra-thin flexible strain and electrocardiographic sensor of the invention comprises: a strain sensor, an electrocardiographic sensor, an analog to digital conversion circuit, an amplifying circuit, a filtering circuit, a microprocessor, a wireless transmission unit and a mobile terminal Among them, the strain sensor and the ECG sensor are ultra-thin flexible sensors, the strain sensor is attached to the surface of the chest, and the two ECG electrodes of the ECG sensor are respectively attached to the surface under the left chest; the strain sensor and the three The resistors with constant resistance form a Wheatstone bridge, and the two outputs of the Wheatstone bridge are electrically connected to the analog-to-digital conversion circuit; the ECG sensor is electrically connected to the analog-to-digital conversion circuit; the analog-to-digital conversion circuit, the amplification circuit, and the filter The circuit and the microprocessor are electrically connected to form a signal acquisition and processing unit; the signal acquisition processing unit and the wireless transmission unit are electrically connected and integrated on one circuit board; the mobile terminal is located outside the human body; and the fluctuation of the chest cavity causes the resistance of the strain sensor to change. , causing the Wheatstone bridge to be unbalanced, thereby generating current as a respiratory signal output The analog-to-digital conversion circuit and the temperature compensation of the Wheatstone bridge are used to eliminate the influence of the body temperature and the ambient temperature change on the measurement of the chest undulation by the variable sensor; the beating of the heart causes a potential difference between the two electrodes of the ECG sensor. The electrocardiographic signal is transmitted to the analog-to-digital conversion circuit; the analog-to-digital conversion circuit converts the simulated respiratory signal and the electrocardiographic signal into digital signals respectively; the amplifying circuit amplifies the signal; the respiratory signal is directly recorded by the microprocessor through the filtering circuit; The electric signal is filtered to remove the noise signal and the high frequency signal; the microprocessor synthesizes the electrocardiogram signal into an electrocardiogram signal, and records the electrocardiogram signal; the respiratory signal and the electrocardiogram signal are transmitted to the mobile terminal through the wireless transmission unit; The cardiopulmonary coupling algorithm is used to calculate the mutual power spectrum and coherence of the ECG signal and the respiratory signal, and the sleep state is determined, and the result is wirelessly transmitted to the mobile terminal through the wireless transmission unit for recording and display.

The strain sensor adopts a structure of a foil strain gauge, which comprises a bonding layer, a flexible substrate, a polymer protective layer, a device layer and a packaging film; wherein the flexible substrate and the packaging film are made of a biocompatible film; the bonding layer is directly contacted and bonded On the skin, high-viscosity bio-adhesive can effectively bind to the skin without causing allergic reactions to the skin; forming a flexible substrate on the bonding layer to carry the above device; forming a rigid polymer on the flexible substrate The protective layer bears the deformation transmitted by the flexible substrate, reduces damage to the device layer, and functions to protect the device layer; forms a device layer on the polymer protective layer, and the device layer is a patterned metal film, which is malleable According to different functions, it is designed into different pattern shapes, and is designed to be malleable fractal structure to realize ductility; a package film is formed on the device layer, and the device is packaged as a whole. Wrapped, protects electronic components from external factors, waterproof and dustproof; the undulation of the chest cavity is transmitted to the protective layer through the flexible substrate, causing deformation of the protective layer, thereby stretching or compressing the device layer, so that the resistance of the device layer occurs. The change causes the Wheatstone bridge that is composed of the strain sensor and the three fixed resistors to be unbalanced. The output current is output through the two outputs of the Wheatstone bridge as a respiratory signal, and the body temperature is removed by the effect of the Wheatstone bridge. The variable sensor measures the influence of chest undulation corresponding to the change of ambient temperature, and the frequency and amplitude of breathing are obtained by the output current. The biocompatible film provides breathability, water repellency and low sensitization to provide biocompatibility for the entire device, enabling the strain sensor to work on the human body for up to 24 hours. The package film also uses a biocompatible film to protect the functional device. The structure is complete and the circuit function and biocompatibility are not destroyed by external liquids.

The electrocardiographic sensor comprises two electrocardiographic electrodes, a serpentine lead wire and a connecting end; wherein the two electrocardiographic electrodes have a distance therebetween; the two electrocardiographic electrodes are respectively connected to the connecting end by a ductile serpentine lead wire; The end is connected to the input end of the analog-to-digital conversion circuit; each of the electrocardiographic electrodes adopts a grid structure, and the lines forming the grid are curved serpentine lines, so that the electrocardiographic electrodes are malleable, and are not attached to the surface of the human body. It will be damaged by skin deformation; the beating of the heart causes a potential change, and a potential difference is generated between two ECG electrodes having a certain distance. As an ECG signal, an electrocardiogram is obtained through the ECG signal, indicating the activity characteristics of the heart.

The wireless transmission unit uses Bluetooth communication to wirelessly transmit the resulting signal to the paired mobile terminal for recording and display.

The sleep state includes shallow sleep, deep sleep and waking; the coupled power is read out through the mutual power spectrum, and the sleep state is judged according to the frequency band in which the coupled power is located; the excessive power of the low frequency band is related to the periodic breathing of the sleep disordered breathing device, Excessive power in the high frequency band is associated with physiological sinus arrhythmia and deep sleep. If the coupled power is in the ultra-low frequency band, it is awake or deep sleep, and the ultra-low frequency band is 0.001 to 0.01 Hz; if the coupling power is in the low frequency band, it is light sleep, and the low frequency band is 0.01-0.1 Hz.

Another object of the present invention is to provide a cardiopulmonary coupled sleep quality detecting method based on an ultra-thin flexible strain and electrocardiographic sensor.

The strain sensor is attached to the surface of the chest, and the two ECG electrodes of the ECG sensor are respectively attached to the surface under the left chest; the strain sensor and the three resistance-changing resistors constitute the Wheatstone bridge, Wheatstone bridge The two output terminals are electrically connected to the analog-to-digital conversion circuit; the electrocardiographic sensor is electrically connected to the analog-to-digital conversion circuit; the analog-to-digital conversion circuit, the amplification circuit, the filter circuit, and the microprocessor are sequentially electrically connected to form a signal acquisition and processing unit; signal acquisition processing The unit and the wireless transmission unit are electrically connected and integrated on one circuit board; the mobile terminal is located outside the human body.

The cardiopulmonary coupled sleep quality detecting method based on the ultra-thin flexible strain and electrocardiographic sensor of the invention comprises the following steps:

1) The fluctuation of the chest cavity causes the resistance of the strain sensor to change, causing the Wheatstone bridge to be unbalanced, resulting in The current is output as a respiratory signal to the analog-to-digital conversion circuit, and the effect of the temperature fluctuation of the body temperature and the ambient temperature is measured by the temperature compensation of the Wheatstone bridge to measure the influence of the undulation of the chest sensor;

2) The beating of the heart causes a potential difference between the two electrodes of the electrocardiographic sensor to be transmitted as an electrocardiographic signal to the analog to digital conversion circuit;

3) an analog-to-digital conversion circuit converts the simulated respiratory signal and the electrocardiographic signal into a digital signal; the amplification circuit amplifies the signal;

4) The breathing signal is directly recorded by the microprocessor through the filter circuit;

5) the electrocardiogram signal is filtered to remove the noise signal and the high frequency signal; the microprocessor synthesizes the electrocardiogram signal into an electrocardiogram signal, and records the electrocardiogram signal; the respiratory signal and the electrocardiogram signal are transmitted to the mobile terminal through the wireless transmission unit;

6) The microprocessor applies the cardiopulmonary coupling algorithm to calculate the cross-power spectrum and coherence of the ECG signal and the respiratory signal, reads the coupled power from the cross-power spectrum, determines the state of sleep, and judges the sleep state, and transmits the result wirelessly. The unit transmits to the mobile terminal for recording and display.

Wherein, in step 6), the cardiopulmonary coupling algorithm calculates the cardiopulmonary coupling index, comprising the steps of: first identifying the QRS complex of the electrocardiogram, detecting the time and magnitude of the occurrence of the R peak, and processing the RR interval signal to obtain The normal heartbeat interval (NN interval), the re-sampling of the respiratory signal measured by the flexible strain sensor, adjusting the sampling frequency, calculating the NN interval and the mutual power spectrum and the coherence of the respiratory signal, thereby obtaining the cardiopulmonary Coupling (CPC) power spectrum.

In step 6), the sleep state is determined by the cardiopulmonary coupling index; the sleep state includes shallow sleep, deep sleep, and awake; the coupled power is read by the cross power spectrum, and the sleep state is determined according to the frequency band in which the coupled power is located; When the coupling power is in the ultra-low frequency band, it is awake or deep sleep, and the ultra-low frequency band is 0.001 to 0.01 Hz; if the coupling power is in the low frequency band, it is light sleep, and the low frequency band is 0.01 to 0.1 Hz.

Advantages of the invention:

The invention adopts an ultra-thin and flexible sensor, can be easily attached to the body surface of the sleeper, does not cause any discomfort or restraint feeling, and basically does not feel the presence of the sensor during the measurement, and minimizes the sleeper's The effect truly reflects the state of the sleeper's sleep; the respiratory and electrocardiographic signals are measured by using an ultra-thin flexible sensor, and then the cardiopulmonary coupling algorithm is used to comprehensively analyze the respiratory and electrocardiographic signals to obtain the quantitative index parameters of the patient's sleep quality. And the apnea characteristic of the apnea syndrome, the signal is transmitted to the mobile terminal wirelessly, the overall system is small in size, and can be conveniently used in different sleeping occasions; the invention is simple and easy, the accuracy is high, and the use is convenient Comfortable.

DRAWINGS

1 is a structural block diagram of an cardiopulmonary coupled sleep quality detecting system based on an ultra-thin flexible strain and an electrocardiographic sensor according to the present invention;

2 is an exploded view of a strain sensor of an cardiopulmonary coupled sleep quality detecting system based on an ultra-thin flexible strain and an electrocardiographic sensor according to the present invention;

3 is a schematic diagram of an electrocardiographic sensor of an cardiopulmonary coupled sleep quality detecting system based on an ultra-thin flexible strain and an electrocardiographic sensor according to the present invention;

4 is a top plan view of a device layer of a strain sensor of an cardiopulmonary coupled sleep quality detecting system based on an ultra-thin flexible strain and electrocardiographic sensor of the present invention;

5 is a schematic diagram of one embodiment of a cardiopulmonary coupled sleep quality detection system based on an ultra-thin flexible strain and electrocardiographic sensor applied to sleep detection according to the present invention.

detailed description

The invention will be further illustrated by the following examples in conjunction with the accompanying drawings.

As shown in FIG. 1 , the cardiopulmonary coupled sleep quality detecting system based on the ultra-thin flexible strain and electrocardiographic sensor of the embodiment includes: a strain sensor, an electrocardiographic sensor, an analog-to-digital conversion circuit, an amplifying circuit, a filtering circuit, and a microprocessor. a wireless transmission unit and a mobile terminal; wherein the strain sensor and the electrocardiographic sensor are ultra-thin flexible sensors, the strain sensor and three resistance-changing resistors form a Wheatstone bridge, and the two outputs of the Wheatstone bridge The electrical connection is electrically connected to the analog-to-digital conversion circuit; the electrocardiographic sensor is electrically connected to the analog-to-digital conversion circuit; the analog-to-digital conversion circuit, the amplification circuit, the filter circuit and the microprocessor are electrically connected in sequence to form a signal acquisition and processing unit.

As shown in FIG. 2, the strain sensor 1 includes an adhesive layer, a flexible substrate 11, a polymer protective layer 12, a device layer 13, and a package film 14; wherein a flexible substrate 11 is formed on the adhesive layer; and formed on the flexible substrate 11. A rigid polymer protective layer 12; a device layer 13 formed on the polymer protective layer 12, the device layer being a patterned metal film; and a package film 14 formed on the device layer 13.

As shown in FIG. 3, the electrocardiographic sensor 2 includes two electrocardiographic electrodes 21, a serpentine lead wire 22, and a connecting end 23; wherein, the two electrocardiographic electrodes 21 have a distance therebetween; and the two electrocardiographic electrodes respectively extend through the extensible The serpentine lead wire 22 is connected to the connection end 23; the connection end is connected to the input end of the analog to digital conversion circuit; each electrocardiographic electrode adopts a grid structure, and the lines constituting the grid are curved serpentine lines.

As shown in FIG. 4, the device layer 13 is a patterned metal film.

As shown in FIG. 5, when detecting the sleep quality of the patient, the strain sensor 1 is attached to the surface of the front chest, and the two electrocardiographic electrodes of the electrocardiographic sensor 2 are respectively attached to the surface 5 cm below the left breast left breast; signal acquisition Processing unit and wireless transmission unit Electrically connected and integrated on a circuit board 3; the mobile terminal 4 is located outside the human body. The wireless transmission unit uses Bluetooth transmission.

The cardiopulmonary coupled sleep quality detecting method based on the ultra-thin flexible strain and electrocardiographic sensor of the embodiment includes the following steps:

1) The fluctuation of the chest cavity causes the resistance of the strain sensor to change, causing the Wheatstone bridge to be unbalanced, thereby generating a current, outputting it as a respiratory signal to the analog-to-digital conversion circuit, and excluding the body temperature by the temperature compensation of the Wheatstone bridge. Corresponding to the temperature change of the surrounding environment, the variable sensor measures the influence of chest undulation;

6) The microprocessor applies the cardiopulmonary coupling algorithm to calculate the mutual power spectrum and coherence of the ECG signal and the respiratory signal, determines the sleep state, and transmits the result to the mobile terminal through the wireless transmission unit for recording and display.

It is to be understood that the present invention is intended to be a further understanding of the invention, and it is understood by those skilled in the art that various modifications and changes can be made without departing from the spirit and scope of the invention and the appended claims It is possible. Therefore, the invention should not be limited by the scope of the invention, and the scope of the invention is defined by the scope of the claims.

Claims

A cardiopulmonary coupled sleep quality detecting system, characterized in that the detecting system comprises: a strain sensor, an electrocardiographic sensor, an analog to digital conversion circuit, an amplifying circuit, a filtering circuit, a microprocessor, a wireless transmission unit and a mobile terminal; wherein Both the strain sensor and the ECG sensor are ultra-thin flexible sensors. The strain sensor is attached to the surface of the chest. The two ECG electrodes of the ECG sensor are attached to the surface below the left chest. The strain sensor and three resistance values. The constant resistance constitutes a Wheatstone bridge, and the two outputs of the Wheatstone bridge are electrically connected to the analog-to-digital conversion circuit; the electrocardiographic sensor is electrically connected to the analog-to-digital conversion circuit; the analog-to-digital conversion circuit, the amplification circuit, the filter circuit, and the micro The processor is electrically connected to form a signal acquisition and processing unit; the signal acquisition processing unit and the wireless transmission unit are electrically connected and integrated on one circuit board; the mobile terminal is located outside the human body; the fluctuation of the chest cavity causes the resistance value of the strain sensor to change, causing benefits The power-on bridge is unbalanced, generating current as a respiratory signal output to analog-to-digital conversion The road, and through the effect of temperature compensation of the Wheatstone bridge, excludes the influence of body temperature and ambient temperature change on the measurement of chest undulation caused by the variable sensor; the beating of the heart causes a potential difference between the two electrodes of the ECG sensor, as the ECG The signal is transmitted to the analog-to-digital conversion circuit; the analog-to-digital conversion circuit converts the simulated breathing signal and the electrocardiographic signal into digital signals respectively; the amplifying circuit amplifies the signal; the breathing signal is directly recorded by the microprocessor through the filtering circuit; the electrocardiographic signal passes through The filter circuit performs filtering to remove the noise signal and the high frequency signal; the microprocessor synthesizes the electrocardiogram signal into an electrocardiogram signal and records the electrocardiogram signal; the respiratory signal and the electrocardiogram signal are transmitted to the mobile terminal through the wireless transmission unit; the microprocessor applies cardiopulmonary coupling The algorithm calculates the mutual power spectrum and the coherence of the electrocardiogram signal and the respiratory signal, determines the sleep state, and transmits the result to the mobile terminal wirelessly through the wireless transmission unit for recording and display.
The detecting system according to claim 1, wherein the strain sensor comprises an adhesive layer, a flexible substrate, a polymer protective layer, a device layer, and a package film; wherein the flexible substrate and the packaging film are made of a biocompatible film; The contact layer is directly contacted and bonded to the skin, using a high-viscosity bioglue; forming a flexible substrate on the adhesive layer; forming a rigid polymer protective layer on the flexible substrate; forming a device layer on the polymer protective layer, the device The layer is a patterned metal film, which is malleable; a package film is formed on the device layer to wrap the device as a whole; the undulation of the chest cavity is transmitted to the protective layer through the flexible substrate, causing deformation of the protective layer, thereby forming a pull on the device layer Stretching or compressing, causing a change in the resistance of the device layer, causing the strain sensor to be unbalanced with the Wheatstone bridge composed of three fixed resistors, outputting current through the two outputs of the Wheatstone bridge as a respiratory signal, The effect of the temperature compensation of the Stone Bridge eliminates the changes in body temperature and ambient temperature, and the variable sensor measures the chest undulation. The effect of the output current is the frequency and amplitude of the breath.
The detecting system according to claim 2, wherein the different patterns are designed according to different functions. Designed to be a malleable fractal structure to achieve extensibility.
The detecting system according to claim 1, wherein said electrocardiographic sensor comprises two electrocardiographic electrodes, a serpentine lead wire and a connecting end; wherein the two electrocardiographic electrodes have a distance therebetween; and two electrocardiograms The electrodes are respectively connected to the connection end by a ductile serpentine lead wire; the connection end is connected to the input end of the analog to digital conversion circuit; each electrocardiographic electrode is malleable; the beating of the heart causes a potential change, and two hearts having a distance A potential difference is generated between the electrodes, and as an electrocardiographic signal, an electrocardiogram is obtained through the electrocardiographic signal, indicating the activity characteristics of the heart.
The detection system according to claim 4, wherein each of the electrocardiographic electrodes has a grid-like structure, and the lines constituting the grid are curved serpentine lines, so that the electrocardiographic electrodes are malleable.
The detection system of claim 1 wherein said wireless transmission unit employs Bluetooth communication.
A cardiopulmonary coupled sleep quality detecting method, characterized in that the detecting method comprises the following steps:

7) The fluctuation of the chest cavity causes the resistance of the strain sensor to change, causing the Wheatstone bridge to be unbalanced, thereby generating a current, outputting it as a respiratory signal to the analog-to-digital conversion circuit, and excluding the body temperature by the temperature compensation of the Wheatstone bridge. Corresponding to the temperature change of the surrounding environment, the variable sensor measures the influence of chest undulation;

8) The beating of the heart causes a potential difference between the two electrodes of the electrocardiographic sensor to be transmitted as an electrocardiographic signal to the analog to digital conversion circuit;

9) an analog-to-digital conversion circuit converts the simulated respiratory signal and the electrocardiographic signal into a digital signal; the amplification circuit amplifies the signal;

10) The breathing signal is directly recorded by the microprocessor through the filter circuit;

11) the electrocardiogram signal is filtered to remove the noise signal and the high frequency signal; the microprocessor synthesizes the electrocardiogram signal into an electrocardiogram signal, and records the electrocardiogram signal; the respiratory signal and the electrocardiogram signal are transmitted to the mobile terminal through the wireless transmission unit;

12) The microprocessor applies the cardiopulmonary coupling algorithm to calculate the cross-power spectrum and coherence of the ECG signal and the respiratory signal, reads the coupled power from the cross-power spectrum, determines the state of sleep, and judges the sleep state, and transmits the result wirelessly. The unit transmits to the mobile terminal for recording and display.
The detecting method according to claim 7, wherein in step 1), the undulation of the chest cavity causes the Wheatstone bridge to be unbalanced, comprising the steps of: undulating the chest cavity through the flexible substrate to the protective layer, causing the protective layer Deformation, thereby stretching or compressing the device layer, causing a change in the resistance of the device layer, causing the strain sensor to be unbalanced with the Wheatstone bridge composed of three fixed resistors, outputting through the two outputs of the Wheatstone bridge The current is ringing as a breathing signal.
The detecting method according to claim 7, wherein in step 6), the sleep state is determined by the cardiopulmonary coupling index; the sleep state includes light sleep, deep sleep, and waking; and the coupled power is read by the cross power spectrum. According to the coupling work The frequency band in which the rate is located determines that the sleep state is obtained; if the coupled power is in the ultra-low frequency band, it is awake or deep sleep, and the ultra-low frequency band is 0.001 to 0.01 Hz; if the coupled power is in the low frequency band, it is light sleep, and the low frequency band is 0.01 to 0.1 Hz.