WO2018100438A1 - Système de démolition de cellules cancéreuses portable basé sur des automates cellulaires à points quantiques et son procédé de fonctionnement - Google Patents

Système de démolition de cellules cancéreuses portable basé sur des automates cellulaires à points quantiques et son procédé de fonctionnement Download PDF

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Publication number
WO2018100438A1
WO2018100438A1 PCT/IB2017/050622 IB2017050622W WO2018100438A1 WO 2018100438 A1 WO2018100438 A1 WO 2018100438A1 IB 2017050622 W IB2017050622 W IB 2017050622W WO 2018100438 A1 WO2018100438 A1 WO 2018100438A1
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WIPO (PCT)
Prior art keywords
qca
gamma
cell
electrodes
cancer cell
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PCT/IB2017/050622
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English (en)
Inventor
Sudipta Roy
Paramartha DUTTA
Debarka MUKHOPADHYAY
Sunanda MONDAL
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Triguna Sen School Of Technology, Assam University, Silchar
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Application filed by Triguna Sen School Of Technology, Assam University, Silchar filed Critical Triguna Sen School Of Technology, Assam University, Silchar
Publication of WO2018100438A1 publication Critical patent/WO2018100438A1/fr

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    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N10/00—Quantum computing, i.e. information processing based on quantum-mechanical phenomena

Definitions

  • the present invention relates to a Quantum Dot Cellular Automata (QCA) based portable Cancer Demolition System and a novel method to generate Gamma-ray waves by the application of Quantum Dot Cellular Automata based nanotechnology for cancer cell treatment.
  • QCA Quantum Dot Cellular Automata
  • the present invention reveals a novel system and method thereof to radiate Gamma-ray waves to demolish cancer affected cells wherein the said QCA based portable Cancer Demolition System required very negligible amount of voltage and consumes very less amount of energy and power compared to conventional methods and systems to generate Gamma-ray waves with same intensity and frequency.
  • Quantum Dot Cellular Automata paradigm [5, 6, 7, 8 and 9] can be employed to design a system that may generate electromagnetic wave with exactly same energy and frequency require to demolish cancer affected cells with regulated supply voltage.
  • the present invention relates to Molecular Quantum Dot Cellular Automata methodology to electronically radiate EM wave, more particularly, gamma rays with the application of 2 to 2.81 rms voltage, more particularly 2.12 rms voltage V rms and at an operating temperature of 1200°K, having exactly same energy and frequency with conventional gamma ray for realization of cancer cell demolition system.
  • Quantum Dot Cellular Automata offers an electronically methodology which may generate an electromagnetic radiation having exactly the same energy and frequency as the conventional high energy Gamma ray.
  • QCA cell electrons while falls from higher quantum energy state to ground state, dissipation occurs. Electrons are raised to a certain quantum energy state by application of controlled/ regulated clock signal energy to achieve desired dissipated energy and frequency.
  • the prime objective of the present invention is to propose a Quantum Dot Cellular Automata (QCA) based portable Cancer Cell Demolition System and a novel method to emit gamma rays using Quantum Dot Cellular Automata based nanotechnology for treatment of cancer affected cells which is capable to overcome the limitations of the existing conventional methods for treatment of cancer affected cells by the application of gamma rays.
  • QCA Quantum Dot Cellular Automata
  • Yet another objective of the present invention is to propose a Quantum Dot Cellular Automata (QCA) based portable Cancer Cell Demolition System, which is capable of controlling the hazardous gamma ray radiation by switching ON/OFF the proposed system.
  • QCA Quantum Dot Cellular Automata
  • Yet another objective of the present invention is to propose a Quantum Dot Cellular Automata (QCA) based portable Cancer Cell Demolition System, which operates on very low supply voltage of 2 to 2.81 rms voltage, more particularly 2.12 rms voltage which is comparatively negligible, consumes power in the range of Watt only and running at an operating temperature of 1200°K.
  • QCA Quantum Dot Cellular Automata
  • Yet another objective of the present invention is to propose a Quantum Dot Cellular Automata (QCA) based portable Cancer Cell Demolition System, which works on a novel method to electronically generate an electromagnetic radiation having exactly the same energy and frequency as the conventional high energy Gamma ray required for cancer cell treatment action.
  • QCA Quantum Dot Cellular Automata
  • Yet another objective of the present invention is to propose a Quantum Dot Cellular Automata (QCA) based portable Cancer Cell Demolition System, which has a novel feature to maintain safety from radiation to the patient and working operators by switching off said system/ device when it is not in use.
  • QCA Quantum Dot Cellular Automata
  • Yet another objective of the present invention is to provide a Quantum Dot Cellular Automata (QCA) based portable Cancer Cell Demolition System, which is more economical and easy to handle than the existing conventional methods for the same.
  • QCA Quantum Dot Cellular Automata
  • the main embodiment of the present invention is a Quantum dot Cellular Automata based Cancer Cell Demolition System (1) comprising of a gamma-ray generating section (2) containing a power supply section (7) and a Gamma ray plate (3) containing an array of molecular QCA cells (9), wherein power supply section (7) is consisting of a ground plane (4) placed above the array of molecular QCA cells (9) level and plurality of electrodes (5) buried under an oxide layer (6); wherein said system (1) implement a novel method to move said QCA cell electrons (9) from higher quantum energy state to ground state leads to radiation of energy which can be used as gamma radiation (8) to target over cancer affected cells when minimum supply rms voltage is 2 to 2.81 rms voltage, more particularly 2.12 rms voltage.
  • Another embodiment of the present invention is to propose a novel method to generate an electromagnetic radiation having exactly the same energy and frequency as the conventional high energy Gamma ray to demolish cancer cells by the application of Quantum Dot Cellular Automata (QCA) based nanotechnology, wherein said QCA cell electrons (9) are raised to a certain quantum energy state by application of controlled/regulated clock signal energy to achieve desired dissipated energy and frequency when said QCA cell electrons (9) falls from higher quantum energy state to ground state, radiation energy emits which can be used as Gamma radiation for treatment of cancer cells with application of minimum voltage of 2 to 2.81 rms voltage, more particularly 2.12 rms voltage.
  • QCA Quantum Dot Cellular Automata
  • Another embodiment of the present invention is a Quantum dot Cellular Automata based Cancer Cell Demolition System (1), wherein said system (1) works at 2 to 2.81 rms voltage, more particularly 2.12 rms voltage Vrms supply, consumes power in the range of Watt only and running at an operating temperature of 1200°K and is able to electrically switched off the radiation while the existing Gamma ray generator works without electricity and radiates all the time even when the device is not in use.
  • Figure 1 shows a perspective view of proposed Quantum dot Cellular Automata based Cancer Cell Demolition System (1) consisting a Gamma-ray generating section (2) comprising of a Gamma-ray plate (3), power supply section (7) consisting of ground plane (4), electrodes (5), oxide layer (6) and radiation direction/radiation head (8).
  • Figure 2 depicts cross section view of said Gamma-ray generating section (2) comprising of said ground plane (4), an array of Quantum dot Cellular Automata cells (9), said electrodes (4) and said oxide layer (6).
  • Figure 3(a) depicts a cross- sectional view of said Gamma-ray plate (3) containing an array of said QCA cells (9) whereas Figure 3(b) views the dimensions of said QCA cells (9) that will replace the square cells in said Gamma-ray plate (12) wherein size and height of the said QCA cell is denoted by d and h respectively.
  • Figure 4 views the four phases of the sinusoidal signals 0; , 2, 0 3 and 0 4 applied to each of said electrodes (5) such that data may flow as shown and also shows submerged said electrodes(5) to generate an electric field E at the level of said molecular QCA cells (9).
  • Figure 5(a) shows perspective view of arrangement of two said electrodes (5) buried in said oxide layer (6) and said ground plane (4); whereas Figure 5 (b) is a cross sectional view of the Figure 5(a) shows arrangement of two said electrodes (5) buried in said oxide layer (6), ground plane (4) and said QCA cell(9).
  • Figure 6 shows a plot of said QCA Cell Size (nm) V s V rms for three different spacing of said electrodes (5).
  • Figure 7 views a plot which depicts a tradeoff between maximum operating temperatures in K, cell size in nm and RMS voltage in volt.
  • the present invention relates to Quantum dot Cellular Automata based Cancer Cell Demolition System (1) comprising of a gamma-ray generating section (2) containing a power supply section (7) and a Gamma ray plate (3) containing an array of molecular QCA cells (9), wherein power supply section (7) is consisting of a ground plane (4) placed above the array of molecular QCA cells (9) level and plurality of electrodes (5) buried under an oxide layer (6); wherein a novel Molecular Quantum Dot Cellular Automata methodology to electronically radiate EM wave with the application of minimum voltage of 2 to 2.81 rms voltage, more particularly 2.12 rms voltage and at an operating temperature of 1200° K, having exactly same energy and frequency with conventional gamma ray for realization of cancer cell demolition system is applied herein.
  • the said QCA cells (9) and electromagnetic clock signal are the most vital ingredients in the present invention of gamma-rays radiated from said QCA cells (9) which consume very less amount of electric energy and power.
  • Each QCA cell (9) is composed of two V shaped molecules and has six redox sites which are considered as quantum dots.
  • Figure 3(a) depicts molecular QCA cells (2) arrangement.
  • cell size (d) to be 1 nm and height (h) to be 1 nm is employed as shown in Figure 3(b).
  • Clock signal is applied through submerged said electrodes (5) buried in said oxide layer (6).
  • Said electrodes (5) carry electromagnetic clock signals and are placed at the bottom of said oxide layer (6).
  • the phase shifted sinusoidal signal is applied to each of said electrodes (5) to energize the electrons.
  • Figure 4 depicts the four phases of the applied sinusoidal signal i.e., 0i, 0 2 , 03 and 0 4 and 0i ⁇ 0 2 ⁇ 0 3 ⁇ 0 4 such that the data may flow in the direction as shown in Figure 4.
  • This electric field M in the Y and -Y directions switch said molecular
  • QCA cell (9) from ACTIVE state to NULL state and vice- versa.
  • Said electrodes (5) have finite radius and potential voltage is applied with respect to said ground plane (4) as shown in Figure 5(a).
  • Average electrode potential [11] is determined as, where V el and V e2 are the potentials on two adjacent said electrodes (5).
  • the electrode potential difference between two adjacent said electrodes (5) can be given as,
  • V e V e2 - V el (2)
  • the RMS voltage V rms can be defined as ⁇ t ⁇ . - If 5 where Vi is maximum allowable V avg and V 2 is minimum allowable V avg [11].
  • the interdependency between cell size and RMS voltage is studied and analyzed in Figure 6. A spacing of 20 nm [11] is applied while selecting V rms and cell size. While selecting the above two parameters, analysis of the temperature issues is also required.
  • Vo is peak potential value of clock signal applied to adjacent said electrodes (5) and minimum RMS voltage should be applied [11, 12].
  • the spacing(s) between said electrodes (5) is kept at 20 nm.
  • the length and radius of said electrode are chosen to be 100 nm and 5 nm respectively.
  • Dielectric like said oxide layer (6) more particularly, Si0 2 whose dielectric constant is 4.2 is used between said electrodes (5) and said QCA cells (9). Said electrodes (5) shall be buried inside said oxide layer (6) [10].
  • QCA cell (9) size is allowed to 1 nm, reduced RMS voltage and maximum operating temperature can be regulated as analyzed in Figure 7.
  • an array of said cells (9) having dimension of 1 nm can be employed with an RMS value of 2.12 rms voltage approximately [11].
  • the electron wave ( (x)) tunneling through the positive X direction and finite potential energy V(x) can be represented using time independent Schrodinger wave equation as given in Equation 4 below,
  • E n is infinite sequence of discrete energy levels corresponding to all possible non- negative integral values of n
  • the electron quantum number and d is said molecular QCA cell (9) dimension. Electrons acquire energy from the applied clock and jump up to higher energy state. But while losing energy they move down to lower energy state. Movement of electrons from higher to lower energy levels leads to radiation of energy. This radiation is of our interest and it is tuned to generate gamma ray realization of proposed QCA based cancer cell demolition system (1).
  • the transitions between these energy states are possible if sum or difference of quantum numbers is an odd number [16, 17, 18, 14]. Transitions are strictly forbidden if both the quantum numbers are even [16, 17, 18, and 14]. Any transition of an electron from higher energy state (n th state) to ground state can be expressed with the help of Equation 6 as, (6)
  • the proposed QCA based Cancer cell demolition system (1) requires Gamma ray (8) energy in the range of 1.24 MeV. Considering this energy radiation i.e., 1.24 MeV and equating it to E n in Equation 6, the relation between electron quantum number n and molecular cell dimension d can be expressed as,
  • the said Quantum dot Cellular Automata based Portable Cancer Cell Demolition System (1) propose a portable Cancer Cell Demolition System to radiate Gamma radiation for the treatment of cancer affected cells, wherein the novel methodology involves in its operation is based on molecular Quantum dot Cellular Automata (QCA) nano technology.
  • QCA Quantum dot Cellular Automata
  • the primary unit of said system (1) is said Gamma-ray plate (3) containing an array of said molecular QCA cells (9) arranged in sequence as shown in Figure 3 a.
  • Each said QCA cell (9) in the plate may be replaced by the molecular counterpart as shown in Figure 3b.
  • Figure 1 depicts said electrodes (5) at the bottom of said gamma ray generator section (2). These said electrodes (5) are buried under said oxide layer (6), more particularly, Si02 layer.
  • Said molecular QCA cells (9) are arranged over said oxide layer (6) as they are arranged over Gamma-ray plate (3).
  • One ground plane (4) is placed above said QCA cell level (9). All the molecular QCA cells (9) are having a size of 1 nm.
  • Said system (1) may work at temperature of 1200°K and execute at an applied voltage of 2 to 2.81 rms voltage, more particularly 2.12 rms voltage. This value of RMS voltage might be supplied to said electrodes (5) buried under the dielectric like said oxide layer (6) through step down transformer.
  • the Gamma-ray generator section (2) in Figure 1 is housed within the Gamma-ray radiation container to complete the structural construction of said QCA based Cancer Demolition System (1) as in Figure 1.
  • Said Gamma-ray generator section (2) contains a power supply section (7) on the upper side and said Gamma ray plate (3).
  • the power supply section (7) is consisting of said electrodes (5), said oxide layer (6) and said ground plane (4).
  • Said Gamma-ray generator (2) runs at a temperature of 1200°K. So there is need to control the inside temperature.
  • the proposed QCA based Cancer Demolition System (1) runs on electricity, runs in 1200 ° K temperature; execute with the supply voltage 2.12 rms voltages and no radiation while it is switched off.
  • Rinaldi "The fabrication of sub- 10 nm planar electrodes and their use for a molecule- based transistor," Nanotechnology, vol. 15, pp. 807 - 811, 2004.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
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  • High Energy & Nuclear Physics (AREA)
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Abstract

L'invention concerne un système de démolition de cellules cancéreuses portable basé sur des automates cellulaires à points quantiques ( 1) qui comprend une section de génération de rayons gamma (2) contenant une section d'alimentation électrique (7) et une plaque de rayons gamma (3) contenant un réseau de cellules QCA moléculaires (9). La section d'alimentation électrique (7) est constituée d'un plan de masse (4) placé au-dessus du niveau du réseau de cellules QCA moléculaires (9) et d'une pluralité d'électrodes (5) enfouies sous une couche d'oxyde (6). Ledit système (1) met en œuvre un nouveau procédé pour déplacer lesdits électrons de cellule QCA ( 9) d'un état d'énergie quantique supérieur à un état de masse, ce qui conduit à un rayonnement d'énergie qui peut être utilisé en tant que rayonnement gamma (8) pour cibler des cellules cancéreuses lorsque la tension efficace d'alimentation minimale est comprise entre 2 et 2,81 de tension efficace, plus particulièrement à 2,12 volts de tension efficace et est capable d'éteindre électriquement le rayonnement tandis que le générateur de rayons gamma existant fonctionne sans électricité et rayonne en permanence même lorsque le dispositif n'est pas en cours d'utilisation.
PCT/IB2017/050622 2016-12-02 2017-02-04 Système de démolition de cellules cancéreuses portable basé sur des automates cellulaires à points quantiques et son procédé de fonctionnement WO2018100438A1 (fr)

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IN201631041316 2016-12-02
IN201631041316 2016-12-02

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1200966A1 (fr) * 1999-03-16 2002-05-02 Gideon Jacobus Johannes Joubert Source de rayons gamma pour la radiographie

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1200966A1 (fr) * 1999-03-16 2002-05-02 Gideon Jacobus Johannes Joubert Source de rayons gamma pour la radiographie

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"A study on energy optimized 4 dot 2 electron two dimensional quantum dot cellular automata logical reversible flip-flops", MICROELECTRONICS JOUNAL, vol. 46, no. 6, 24 April 2015 (2015-04-24), pages 519 - 530, XP029228617 *
F KRIM ET AL.: "Analysis of field-driven clocking for molecular quantum-dot cellular automata based circuits", JOURNAL OF COMPUTATIONAL ELECTRONICS, vol. 9, no. 1, 10 October 2009 (2009-10-10), pages 16 - 30, XP019790429 *

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