WO2018096138A1 - Solvent-free alkane sulfonation - Google Patents

Solvent-free alkane sulfonation Download PDF

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Publication number
WO2018096138A1
WO2018096138A1 PCT/EP2017/080495 EP2017080495W WO2018096138A1 WO 2018096138 A1 WO2018096138 A1 WO 2018096138A1 EP 2017080495 W EP2017080495 W EP 2017080495W WO 2018096138 A1 WO2018096138 A1 WO 2018096138A1
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Prior art keywords
sulfur trioxide
initiator
compound
acid
precursor
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PCT/EP2017/080495
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French (fr)
Inventor
Timo Ott
Ingo BIERTÜMPEL
Original Assignee
Grillo-Werke Ag
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Application filed by Grillo-Werke Ag filed Critical Grillo-Werke Ag
Priority to CA3041752A priority Critical patent/CA3041752A1/en
Priority to BR112019010643A priority patent/BR112019010643A2/en
Priority to CN201780073220.9A priority patent/CN110023281A/en
Priority to JP2019527893A priority patent/JP2019535774A/en
Priority to MYPI2019002945A priority patent/MY191259A/en
Priority to US16/349,113 priority patent/US10961182B2/en
Priority to RU2019120030A priority patent/RU2019120030A/en
Priority to MX2019004519A priority patent/MX2019004519A/en
Priority to KR1020197014338A priority patent/KR102300703B1/en
Priority to ES17811244T priority patent/ES2965853T3/en
Priority to EP17811244.7A priority patent/EP3544954B1/en
Priority to AU2017365556A priority patent/AU2017365556A1/en
Publication of WO2018096138A1 publication Critical patent/WO2018096138A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C409/00—Peroxy compounds
    • C07C409/42—Peroxy compounds containing sulfur atoms
    • C07C409/44—Peroxy compounds containing sulfur atoms with sulfur atoms directly bound to the —O—O— groups, e.g. persulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/04—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups
    • C07C303/06—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups by reaction with sulfuric acid or sulfur trioxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C407/00—Preparation of peroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C07C303/44—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group

Definitions

  • the present invention relates to an alkane-sulfonation process using alkane and sulfur trioxide, especially pure sulfur trioxide (100%) under solvent-free conditions in the presence of an initiator. It further relates to the use of a precursor which forms "in-situ" an initiator for manufacturing of alkanesulfonic acids, especially methanesulfonic acids.
  • Alkanesulfonic acids are organic acids that can reach a similar acid strength as that of inorganic mineral acids, for example, sulfuric acid.
  • the sulfonic acids are non-oxidizing and do not give off vapors that are harmful to health, as can be observed with hydrochloric and nitric acids.
  • many sulfonic acids, for example, methanesulfonic acid are biologically degradable.
  • the applications of sulfonic acids are many, for example, in cleaning agents, surfactants, galvanic and electronic industry, as catalysts, and in organic synthesis, pharmaceutical chemistry, for example, as protective groups.
  • the salts of sulfonic acids are employed, for example, as surfactants, for example, sodium dodecylsulfonate, or in the electroplating industry, especially as tin, zinc, silver, lead and indium, but also other metal, alkylsulfonates.
  • organic salts are employed in pharmaceutical chemistry.
  • the very high solubility of alkyl sulfonates plays an important role, in particular. Further, no harmful gases are formed in electrolysis, and the use of toxic compounds, for example, cyanide, which is common in many cases, is dispensed with.
  • the structurally simplest representative of alkanesulfonic acids is methanesulfonic acid.
  • reaction conditions in conventional processes of alkanesulfonic acid production can result in undesirable side products, which even manifest themselves as disturbing inhibitors in the production of alkanesulfonic acids. This may lead to termination of the actual reaction for preparing the alkanesulfonic acid, but also to impurities, formation of side products and poor yields, based on sulfur trioxide and methane.
  • WO 2007/136425 A2 discloses the use of the compound di(methanesulfonyl) peroxide (DMSP), which must be prepared by a complex electrolysis and, in addition, is a crystallizable highly explosive solid, as an initiator in a reaction in which methanesulfonic acid is formed from sulfur trioxide and methane.
  • DMSP di(methanesulfonyl) peroxide
  • ALK is a branched or unbranched alkyl group, especially a methyl, ethyl, propyl, butyl, isopropyl, isobutyl group, or a higher alkyl group
  • X hydrogen, zinc, aluminium, an alkali or alkaline earth metal, as an initiator- precursor for preparing alkanesulfonic acids, especially methanesulfonic acids from alkane, especially methane, and sulfur trioxide, especially pure sulfur trioxide.
  • the object of the invention is achieved by a process for manufacturing alkanesulfonic acids, especially methanesulfonic acid, comprising the following steps:
  • the reaction mixture contains essentially of the respective alkanesulfonic acid, especially methanesulfonic acid, as well as sulfuric acid.
  • This mixture of alkanesulfonic acid, especially methanesulfonic acid (MSA), and H 2 S0 4 might afterwards be used as the respective mixture.
  • MSA methanesulfonic acid
  • H 2 S0 4 H 2 S0 4
  • the alkanesulfonic acid especially MSA
  • the method of the invention comprises the optional step of the purifying the reaction product, which might be done by distillation or extraction.
  • alkanesulfonic acids might be used in different technical fields, i.e. as cleaning agent (cleaning comprising the area of cleaning and caring, home care as well as industrial and institutional cleaning of hard and soft surfaces, i.e. in dishwashing, commercial laundry, cleaning and sanitation, vehicle and transportation care, concrete cleaning, membrane cleaning, and others), for regeneration of ion exchange resins, in galvanic proceedings, in the area of oil, gas, mining, treatment of metals and/or their surfaces, in different areas of pharmaceutical, chemical and argro-chemical industry or in the production of biodiesel.
  • MSA might also be used in galvanization process of plastics, the broad area of batteries, such as lead battery recycling and recycling in general, such as metal recycling, as well as borane generation are further possible areas of application.
  • the compound as defined above in formula (I) is present in a mixture of the invention which contains additionally at least one compound selected from the group consisting of formula II to XI, i. e. II, III, IV, V, VI, VII, VIII, IX, X, or XI :
  • the compound as defined above or the mixture of the invention is present in sulfuric acid or alkanesulfonic acid, especially methanesulfonic acid.
  • alkanesulfonic acids especially methanesulfonic acid
  • hydrogen peroxide especially hydrogen peroxide
  • the isolation can be effected by extraction, chromatography, precipitation, recrystallization, freeze-drying or similar methods under mild conditions.
  • the isolation can be effected by means of precipitation or chromatography.
  • Inert support materials and inert solvents, such as sulfuric or sulfonic acids, are employed therein.
  • the use of organic solvents is also possible.
  • inert support materials used for isolation are in particular those which do not negatively interfere with components being the actual reaction partners, e.g. by reducing the yield of the compound of the invention.
  • inert support materials can either chemisorb or physisorb - or both - a chemical compound, without destroying its functionality or structure in an irreversible way. Examples are materials based on e.g. silicon dioxide, aluminium oxide, zirconium oxide and the like.
  • sulfur trioxide is used in a form of oleum with a trioxide content of 50 % (w/w) or less, or 65 % (w/w) or more.
  • the use of pure sulfur trioxide is preferred in the process for manufacturing alkanesulfonic acids according to the present invention.
  • a circulation of solvent is not necessary, alkanes comprising higher amounts of impurities compared to the prior art can be used.
  • Impurities usually are enriched in the solvent leading to a reduced yield of MSA.
  • the invention also relates to a process for manufacturing alkanesulfonic acids especially methanesulfonic acids, comprising the steps stated below:
  • Sulfur trioxide especially pure sulfur trioxide is reacted with an alkane in a reactor.
  • alkanes with a low boiling point the use of a high-pressure reactor is necessary.
  • pentane and higher alkanes a common laboratory reactor is sufficient.
  • gaseous alkanes for example, methane
  • a pressure of 1 to 200 bar gas pressure is set.
  • the initiator-precursor e.g. alkanesulfonic hydroperoxide
  • reacts "in situ" to a suitable initiator is added to this solution.
  • the initiator-precursor is prepared by reacting an alkanesulfonic acid or a solution of such alkanesulfonic acid with hydrogen peroxide to the alkanesulfonic hydroperoxide according to the reaction scheme 1 and can optionally be isolated :
  • reaction scheme 1 ALK-S0 2 -OH + H 2 0 2 ⁇ ALK-S0 2 -0-0-H + H 2 0.
  • the alkanesulfonic hydroperoxide (initiator-precursor) reacts "in situ" during the addition to the reactor to an alkanesulfonic sulfuric peroxoanhydride according to reaction scheme 2:
  • Reaction scheme 2 ALK-S0 2 -0-OH + S0 3 ⁇ ALK-S0 2 -0-0-S0 2 -OH.
  • Respective alkanesulfonic sulfuric peroxoanhydrides as initiators in the production of methanesulfonic acids are described in WO 2015/071455 Al.
  • the initiator is produced first in an additional reactor and afterwards added to the main reactor in which the process for the production of methanesulfonic acid or any other alkanesulfonic acid takes place.
  • an initiator precursor is formed which might be isolated but can be added without further purification.
  • Said initiator precursor being an alkanesulfonic hydroperoxide, reacts in-situ during the addition to the main reactor with the alkane and sulfur trioxide to form methanesulfonic acid.
  • concentration of the hydrogen peroxide may be 20 to 100% (w/w).
  • the reaction is completed at 0 to 100 °C.
  • the raw product can be processed by extraction, crystallization, distillation or chromatography.
  • This process can be applied in both batch- and continuous reactor systems.
  • the invention further relates to the use of an initiator precursor as defined above or a mixture as defined above in a device for performing the process for manufacturing an alkanesulfonic acid, especially methansulfonic acid, wherein the device comprises a reactor (1) in which sulfur trioxide reacts with the compound of formula (I) as initiator-precursor to form an initiator; and reaction of said "in-situ"-built initiator with an alkane, especially methane; a distillation means (2) for distilling the product formed in the reactor (1); and a filling means (3); as well as connection means to connect the reactor (1) with the distillation means (2), and the filling means (3) with the distillation means (2).
  • a reactor (1) in which sulfur trioxide reacts with the compound of formula (I) as initiator-precursor to form an initiator; and reaction of said "in-situ"-built initiator with an alkane, especially methane
  • a distillation means (2) for distilling the product formed in the reactor (1)
  • Fig 1 is a scheme of a process for the sulfonation using pure sulfur trioxide of an alkane (e.g. methane) including purification (e.g. distillation) as well as of a device for the production of methanesulfonic acid.
  • an alkane e.g. methane
  • purification e.g. distillation
  • the process according to the invention allows for alkanesulfonation, especially methanesulfonation, in a reactor system using sulfur trioxide, especially pure sulfur trioxide, with alkane, especially methane, with addition of an initiator precursor.
  • the raw product might be purified by distillation, enabling the production of alkanesulfonic acid in high purity, especially methanesulfonic acid, as distillate.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to an alkane-sulfonation process using alkane and sulfur trioxide, especially pure sulfur trioxide (100%) under solvent-free conditions in the presence of an initiator. It further relates to the use of a precursor which forms "in-situ" an initiator for manufacturing of alkanesulfonic acids, especially methanesulfonic acids.

Description

Solvent-free alkane sulfonation
The present invention relates to an alkane-sulfonation process using alkane and sulfur trioxide, especially pure sulfur trioxide (100%) under solvent-free conditions in the presence of an initiator. It further relates to the use of a precursor which forms "in-situ" an initiator for manufacturing of alkanesulfonic acids, especially methanesulfonic acids.
Alkanesulfonic acids are organic acids that can reach a similar acid strength as that of inorganic mineral acids, for example, sulfuric acid. However, in contrast to usual mineral acids such as sulfuric and nitric acids, the sulfonic acids are non-oxidizing and do not give off vapors that are harmful to health, as can be observed with hydrochloric and nitric acids. Further, many sulfonic acids, for example, methanesulfonic acid, are biologically degradable. The applications of sulfonic acids are many, for example, in cleaning agents, surfactants, galvanic and electronic industry, as catalysts, and in organic synthesis, pharmaceutical chemistry, for example, as protective groups. The salts of sulfonic acids are employed, for example, as surfactants, for example, sodium dodecylsulfonate, or in the electroplating industry, especially as tin, zinc, silver, lead and indium, but also other metal, alkylsulfonates. Furthermore, organic salts are employed in pharmaceutical chemistry. The very high solubility of alkyl sulfonates plays an important role, in particular. Further, no harmful gases are formed in electrolysis, and the use of toxic compounds, for example, cyanide, which is common in many cases, is dispensed with. The structurally simplest representative of alkanesulfonic acids is methanesulfonic acid. US 2,493,038 describes the preparation of methanesulfonic acid from S03 and methane. US 2005/0070614 describes further methods for preparing methanesulfonic acid, and its application. The methods known in the prior art are in part complicated, cost-intensive, and lead to undesirable products because of the harsh reaction conditions.
The reaction conditions in conventional processes of alkanesulfonic acid production can result in undesirable side products, which even manifest themselves as disturbing inhibitors in the production of alkanesulfonic acids. This may lead to termination of the actual reaction for preparing the alkanesulfonic acid, but also to impurities, formation of side products and poor yields, based on sulfur trioxide and methane.
WO 2007/136425 A2 discloses the use of the compound di(methanesulfonyl) peroxide (DMSP), which must be prepared by a complex electrolysis and, in addition, is a crystallizable highly explosive solid, as an initiator in a reaction in which methanesulfonic acid is formed from sulfur trioxide and methane.
WO 2015/071365 Al and WO 2015/071455 Al both describe processes for the sulfonation of alkanes. The main steps are: 1) Synthesis of an initiator/initiator-solution.
2) Preparation of a sulfur trioxide-solution (oleum) by dissolving sulfur trioxide in an inert solvent (e.g. sulfuric acid)
3) Reaction of oleum with the corresponding alkane after or during
addition of the initiator/ initiator- solution in a high-pressure-reactor. 4) Quenching of non-reacted starting material
5) Purification (e.g. distillation, crystallization etc.)
6) Recycling of the inert solvent (e.g. sulfuric acid). It is the object of the present invention to provide an improved process for manufacturing alkanesulfonic acid, especially methanesulfonic acid, allowing improved reaction control. Further, requirements for sulfurtrioxide and alkanes should be not of relevance, meaning that not only absolute pure raw materials might be used, but that impurities do not affect negatively the reaction.
The object of the present invention is achieved by use of a compound of the formula (I)
Figure imgf000004_0001
wherein ALK is a branched or unbranched alkyl group, especially a methyl, ethyl, propyl, butyl, isopropyl, isobutyl group, or a higher alkyl group, and X = hydrogen, zinc, aluminium, an alkali or alkaline earth metal, as an initiator- precursor for preparing alkanesulfonic acids, especially methanesulfonic acids from alkane, especially methane, and sulfur trioxide, especially pure sulfur trioxide.
In a further embodiment the object of the invention is achieved by a process for manufacturing the compound as defined above with X = H, comprising reacting an alkanesulfonic acid, especially methanesulfonic acid, with hydrogen peroxide. It might be followed by the isolation of the compound.
In a further embodiment the object of the invention is achieved by a process for manufacturing alkanesulfonic acids, especially methanesulfonic acid, comprising the following steps:
- providing sulfur trioxide;
- reacting the sulfur trioxide with an alkane, especially methane, in a high-pressure autoclave or laboratory reactor;
- setting a pressure of from 1 to 200 bar; - preparing the initiator-precursor according to formula (I), by reacting an alkanesulfonic acid or a solution containing the alkanesulfonic acid with a 30 % to 100 % (w/w) hydrogen peroxide solution;
- adding the initiator-precursor according to formula (I) or a solution thereof to the reactor;
- controlling the temperature of the reaction mixture at 0 °C to 100 °C;
- if necessary purifying the reaction product, for example, by distillation or extraction. After the reaction has taken part, the reaction mixture contains essentially of the respective alkanesulfonic acid, especially methanesulfonic acid, as well as sulfuric acid. This mixture of alkanesulfonic acid, especially methanesulfonic acid (MSA), and H2S04 might afterwards be used as the respective mixture. The combination of an alkanesulfonic acid, especially methanesulfonic acid, and sulfuric acid provides a strong acid in which even gold might be dissoluted enabling different fields of technical applicability.
Alternatively, the alkanesulfonic acid, especially MSA, might be separated i.e. the method of the invention comprises the optional step of the purifying the reaction product, which might be done by distillation or extraction.
But also alkanesulfonic acids, and specially methanesulfonic acids, might be used in different technical fields, i.e. as cleaning agent (cleaning comprising the area of cleaning and caring, home care as well as industrial and institutional cleaning of hard and soft surfaces, i.e. in dishwashing, commercial laundry, cleaning and sanitation, vehicle and transportation care, concrete cleaning, membrane cleaning, and others), for regeneration of ion exchange resins, in galvanic proceedings, in the area of oil, gas, mining, treatment of metals and/or their surfaces, in different areas of pharmaceutical, chemical and argro-chemical industry or in the production of biodiesel. MSA might also be used in galvanization process of plastics, the broad area of batteries, such as lead battery recycling and recycling in general, such as metal recycling, as well as borane generation are further possible areas of application.
This invention enables major modifications leading to an improved process compared with the prior art by:
- Preparing the preferred initiator "in situ" using less or even no solvent.
Easier purification of the product, due to higher product-concentrations No recycling of the inert solvent.
Where applicable:
- Avoiding the preparation of sulfur trioxide-solutions.
Reaction conditions without added solvent.
Evaporating non-reacted sulfur trioxide, instead of quenching.
In particular, the compound as defined above in formula (I) is present in a mixture of the invention which contains additionally at least one compound selected from the group consisting of formula II to XI, i. e. II, III, IV, V, VI, VII, VIII, IX, X, or XI :
Figure imgf000006_0001
Figure imgf000007_0001
Figure imgf000007_0002
VII VIII IX X
and combinations thereof.
In another embodiment the compound as defined above or the mixture of the invention is present in sulfuric acid or alkanesulfonic acid, especially methanesulfonic acid.
For example, the compound of formula (I) with X = H can be manufactured by a process comprising reacting alkanesulfonic acids, especially methanesulfonic acid, with hydrogen peroxide. The thus obtained compound might be isolated but will preferably be used as initiator-precursor without any further isolation and/or cleaning step.
In particular, the isolation can be effected by extraction, chromatography, precipitation, recrystallization, freeze-drying or similar methods under mild conditions. In a particular embodiment of the process according to the invention, the isolation can be effected by means of precipitation or chromatography. Inert support materials and inert solvents, such as sulfuric or sulfonic acids, are employed therein. The use of organic solvents is also possible.
Inert support materials used for isolation are in particular those which do not negatively interfere with components being the actual reaction partners, e.g. by reducing the yield of the compound of the invention. Furthermore, inert support materials can either chemisorb or physisorb - or both - a chemical compound, without destroying its functionality or structure in an irreversible way. Examples are materials based on e.g. silicon dioxide, aluminium oxide, zirconium oxide and the like.
Surprisingly it has been found that instead of using oleum, as described in the prior art, also pure sulfur trioxide can be used according to the present invention . This avoids the preparation of sulfur trioxide solutions. The reaction conditions are here without added solvents. Further, non-reacted sulfur trioxide can evaporate, avoiding the necessity quenching it.
In a further embodiment, sulfur trioxide is used in a form of oleum with a trioxide content of 50 % (w/w) or less, or 65 % (w/w) or more. Surprisingly it has been found that contrary to the prior art for the processes of the present invention also oleum with a sulfur trioxide content of 65 % (w/w) or more, especially of 70 % w/w or more can be used without negatively affecting the inventive process. Even pure sulfur trioxide (100 % (w/w) sulfur trioxide) may be used.
Due to the advantages being connected with the use of pure sulfur trioxide mentioned above, the use of pure sulfur trioxide is preferred in the process for manufacturing alkanesulfonic acids according to the present invention. As contrary to the prior art, a circulation of solvent is not necessary, alkanes comprising higher amounts of impurities compared to the prior art can be used. Impurities usually are enriched in the solvent leading to a reduced yield of MSA. By avoiding solvents and thus a circulation of them, impurities originating from the alkanes are not negatively influencing the production of MSA when pure sulfur trioxide is employed. The invention also relates to a process for manufacturing alkanesulfonic acids especially methanesulfonic acids, comprising the steps stated below:
Sulfur trioxide, especially pure sulfur trioxide is reacted with an alkane in a reactor. For alkanes with a low boiling point, the use of a high-pressure reactor is necessary. For pentane and higher alkanes, a common laboratory reactor is sufficient. In the case of gaseous alkanes, for example, methane, a pressure of 1 to 200 bar gas pressure is set. The initiator-precursor (e.g. alkanesulfonic hydroperoxide) that reacts "in situ" to a suitable initiator is added to this solution. The initiator-precursor is prepared by reacting an alkanesulfonic acid or a solution of such alkanesulfonic acid with hydrogen peroxide to the alkanesulfonic hydroperoxide according to the reaction scheme 1 and can optionally be isolated :
Reaction scheme 1 : ALK-S02-OH + H202→ ALK-S02-0-0-H + H20. The alkanesulfonic hydroperoxide (initiator-precursor) reacts "in situ" during the addition to the reactor to an alkanesulfonic sulfuric peroxoanhydride according to reaction scheme 2:
Reaction scheme 2 : ALK-S02-0-OH + S03 → ALK-S02-0-0-S02-OH. ("in situ"-reaction) Respective alkanesulfonic sulfuric peroxoanhydrides as initiators in the production of methanesulfonic acids are described in WO 2015/071455 Al. In said prior art document, the initiator is produced first in an additional reactor and afterwards added to the main reactor in which the process for the production of methanesulfonic acid or any other alkanesulfonic acid takes place. Contrary thereto, in the present application an initiator precursor is formed which might be isolated but can be added without further purification. Said initiator precursor, being an alkanesulfonic hydroperoxide, reacts in-situ during the addition to the main reactor with the alkane and sulfur trioxide to form methanesulfonic acid. The concentration of the hydrogen peroxide may be 20 to 100% (w/w). Subsequently, the reaction is completed at 0 to 100 °C. The raw product can be processed by extraction, crystallization, distillation or chromatography.
This process can be applied in both batch- and continuous reactor systems.
The invention further relates to the use of an initiator precursor as defined above or a mixture as defined above in a device for performing the process for manufacturing an alkanesulfonic acid, especially methansulfonic acid, wherein the device comprises a reactor (1) in which sulfur trioxide reacts with the compound of formula (I) as initiator-precursor to form an initiator; and reaction of said "in-situ"-built initiator with an alkane, especially methane; a distillation means (2) for distilling the product formed in the reactor (1); and a filling means (3); as well as connection means to connect the reactor (1) with the distillation means (2), and the filling means (3) with the distillation means (2). Fig 1 is a scheme of a process for the sulfonation using pure sulfur trioxide of an alkane (e.g. methane) including purification (e.g. distillation) as well as of a device for the production of methanesulfonic acid.
The process according to the invention allows for alkanesulfonation, especially methanesulfonation, in a reactor system using sulfur trioxide, especially pure sulfur trioxide, with alkane, especially methane, with addition of an initiator precursor. The raw product might be purified by distillation, enabling the production of alkanesulfonic acid in high purity, especially methanesulfonic acid, as distillate.
In the following the invention is further illustrated in an exemplary way taken the preparation of methanesulfonic acid as an example.
Example 1 : Preparation of the initiator-precursor solution
To 100 ml of methanesulfonic acid, 78 ml of 60% (w/w) hydrogen peroxide was added dropwise with external cooling and intensive stirring.
Synthesis protocol :
In a 3.75 L autoclave, 2000 g of pure sulfur trioxide was charged, and the temperature controlled to 50°C. After a pressure of 100 bar of methane gas was set, intensive stirring is performed. Now, the initiator-precursor is metered dropwise to the solution. The pressure dropped down to 50 bar within 30 minutes. Afterwards the pressure was set to 100 bar again. The pressure dropped again down to 50 bar. The pressure was set again to 100 bar. Finally, the pressure dropped down to 30 bar. The yield is higher than 90%, based on sulfur trioxide. The reaction product contains 91% (w/w) methanesulfonic acid.

Claims

C L A I M S :
1. Use of a compound of the formula (I)
ALK-SO2-O-O-X (I), wherein ALK is a branched or unbranched alkyl group, especially a methyl, ethyl, propyl, butyl, isopropyl, isobutyl group, or a higher alkyl group, and X = hydrogen, zinc, aluminium, an alkali or alkaline earth metal, as an initiator- precursor for preparing alkanesulfonic acids, especially methanesulfonic acids from alkane, especially methane, and sulfur trioxide, especially pure sulfur trioxide.
2. A mixture containing a compound as defined in claim 1 and at least one compound selected from the group consisting of following formulae (II) to (X)
Figure imgf000012_0001
Figure imgf000013_0001
Figure imgf000013_0002
VII VIII IX X and combinations thereof.
3. The compound as defined in claim 1 or the mixture of claim 2 in sulfuric acid or alkylsulfonic acid, especially methanesulfonic acid or combinations thereof.
4. Use of the mixture according to claim 2 or 3 as an initiator-precursor for preparing alkanesulfonic acids, especially methanesulfonic acid, from alkane, especially methane, and sulfur trioxide, especially pure sulfur trioxide.
5. A process for manufacturing the compound as defined in claim 1 with X = H, comprising the following steps:
- reacting an alkanesulfonic acid, especially methanesulfonic acid, with hydrogen peroxide;
- if necessary followed by the isolation of the compound.
6. A process for manufacturing alkanesulfonic acids, especially methanesulfonic acid, comprising the following steps:
- providing sulfur trioxide;
- reacting the sulfur trioxide with an alkane, especially methane, in a high-pressure autoclave or laboratory reactor; - setting a pressure of from 1 to 200 bar;
- preparing the compound as defined in claim 1 or the mixture of claim 2 or 3 as initiator-precursor by reacting an alkanesulfonic acid or a solution containing the alkanesulfonic acid with a 30 % to 100 % (w/w) hydrogen peroxide solution;
- adding the initiator-precursor or a solution thereof to the reactor;
- controlling the temperature of the reaction mixture at 0 °C to 100 °C;
- if necessary purifying the reaction product, for example, by distillation or extraction.
7. Process according to claim 5 or 6, wherein the sulfur trioxide is oleum, preferably with a sulfur trioxide content of 50 % (w/w) or less or 65 % (w/w) or more.
8. Process according to claim 5 or 6, wherein the sulfur trioxide is pure sulfur trioxide.
9. Use of an initiator-precursor as defined in claim 1 or the mixture of claim 2 or 3 in a device for performing the process according to claim 6, wherein the device comprises:
- a reactor (1) in which sulfur trioxide reacts with the compound as defined in claim 1 as initiator-precursor to form an initiator; and reaction of said "in-situ"-built initiator with an alkane, especially methane;
- a distillation means (2) for distilling the product formed in the reactor
(1) ; and
- a filling means (3); as well as
- connection means to connect the reactor (1) with the distillation means
(2) , and the filling means (3) with the distillation means (2).
PCT/EP2017/080495 2016-11-28 2017-11-27 Solvent-free alkane sulfonation WO2018096138A1 (en)

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WO2020187897A1 (en) 2019-03-21 2020-09-24 Basf Se Method for the production of alkane sulfonic acid at non-superacidic conditions
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WO2020064573A1 (en) * 2018-09-25 2020-04-02 Basf Se Catalysts for the synthesis of alkanesulfonic acids
CN112739681A (en) * 2018-09-25 2021-04-30 巴斯夫欧洲公司 Cation as catalyst in production of alkane sulfonic acid
WO2020126855A1 (en) * 2018-12-21 2020-06-25 Basf Se Mixture comprising methanesulfonic acid and sulfuric acid
WO2020187897A1 (en) 2019-03-21 2020-09-24 Basf Se Method for the production of alkane sulfonic acid at non-superacidic conditions
EP3712123A1 (en) * 2019-03-21 2020-09-23 Grillo-Werke AG Process for the preparation of isotope labelled alkane sulfonic acid
WO2020187902A1 (en) 2019-03-21 2020-09-24 Grillo-Werke Ag Method for the production of haloalkane sulfonic acid at non-super acidic conditions
WO2020187901A1 (en) * 2019-03-21 2020-09-24 Grillo-Werke Ag Process for the preparation of haloalkanesulfonic acids from sulfur trioxide and a haloalkane at superacidic conditions
WO2020187893A1 (en) * 2019-03-21 2020-09-24 Basf Se Method for the production of alkane sulfonic acid at superacidic conditions
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WO2021023583A1 (en) 2019-08-07 2021-02-11 Basf Se Process for the production of alkanesulfonic acids
WO2021063730A1 (en) 2019-10-01 2021-04-08 Basf Se Process for manufacturing alkanesulfonic acids
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