WO2018094138A1 - 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1h-1,2,4-triazol-1-yl) propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation - Google Patents
4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1h-1,2,4-triazol-1-yl) propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation Download PDFInfo
- Publication number
- WO2018094138A1 WO2018094138A1 PCT/US2017/062149 US2017062149W WO2018094138A1 WO 2018094138 A1 WO2018094138 A1 WO 2018094138A1 US 2017062149 W US2017062149 W US 2017062149W WO 2018094138 A1 WO2018094138 A1 WO 2018094138A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- difluorophenyl
- triazol
- benzonitrile
- difluoro
- pyridin
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Definitions
- metalloenzyme inhibitor compounds and their use as fungicides.
- the disclosure of this application is expressly incorporated by reference herein.
- This patent application describes various routes to generate metalloenzyme inhibiting fungicides. It may be advantageous to provide more direct and efficient methods for the preparation of metalloenzyme inhibiting fungicides and related compounds, e.g., by the use of reagents and/or chemical intermediates which provide improved time and cost efficiency.
- halogen refers to one or more halogen atoms, defined as F, CI, Br, and I.
- organometallic refers to an organic compound containing a metal, especially a compound in which a metal atom is bonded directly to a carbon atom.
- Room temperature is defined herein as about 20 °C to about 25 °C.
- references to the compounds of Formula I- II are read as also including optical isomers and salts. Specifically, when compounds of Formula I-II contain a chiral carbon, it is understood that such compounds include optical isomers and racemates thereof.
- Exemplary salts may include: hydrochloride, hydrobromide, hydroiodide, and the like.
- Method A Use of lithium bis(trimethylsilyl)amide (LiHMDS) in THF.
- Lithium bis(trimethylsilyl)amide (1.5 M solution in THF, 128 mL, 192 mmol) was added via syringe and stirred at -30 °C for 90 min. The reaction was quenched with 4 N HCl and the resulting mixture was stirred for 1 h. The organic layer was washed with brine (2 x 60 mL), and then saturated aqueous sodium bicarbonate (50 mL). The organic layer was filtered and treated with saturated aqueous sodium thiosulfate (200 mL). The resulting mixture was stirred for 1 h and filtered through filter paper.
- Method Bl Use of lithium bis(trimethylsilyl)amide (LiHMDS) in THF/toluene.
- LiHMDS lithium bis(trimethylsilyl)amide
- a 500 mL three-neck flask was fitted with a thermocouple, a condenser with a nitrogen inlet, a septum, and a mechanical stirrer. After flushing with nitrogen, 4-((6-(2-(2,4- difluorophenyl)- 1 , 1 -difluoro-2-hydroxy-3-( 1H- 1 ,2,4-triazol- 1 -yl)propyl)pyridin-3- yl)oxy)benzonitrile (II) (7.5 g, 16.0 mmol) was added, followed by dry toluene (100 mL).
- II lithium bis(trimethylsilyl)amide
- the aqueous phase was treated with 2 N HC1 (25 mL) to pH 3.
- the aqueous layer was extracted with ethyl acetate (2 x 60 mL).
- the organic phase was filtered and returned to the separatory funnel, and residual water was separated.
- the organic phase was concentrated to afford a yellow glass.
- Toluene 150 mL was added and some of the toluene was removed on the rotovap.
- the mixture was filtered and concentrated to about 25 mL.
- the warm solution was seeded and stirred at RT for about 1 h.
- the suspension was cooled to 5 °C and stirred for 1 h.
- the solid was collected via filtration and washed with toluene.
- the reaction was stirred at -30 °C for 30 min then quenched with 112 mL of water and the jacket warmed to 20 °C. After stirring for 1 h, the layers were separated and the organic layer discarded. The aqueous layer was washed with dichloromethane (75 mL). The aqueous layer was extracted with ethyl acetate (150 mL) and the aqueous layer was discarded. The organic layer was washed with brine (100 mL). Water (75 mL) was added to the organic layer and the pH was adjusted to 5-6 using 2 N HC1. The aqueous layer was discarded.
- the organic layer was quantified (143.16 g, 5.7 wt%, 8.16 g, 102% in pot yield).
- the organic layer was atmospherically distilled to about a volume of 85 mL and was heated to 70 °C.
- the mixture was seeded with product crystals and held at 70 °C for 30 min before adding heptane (75 mL) over 10 min.
- the light slurry was cooled to 20 °C over 10 h.
- reaction mixture Upon completing base addition, the reaction mixture was allowed to warm up to 15 °C. After 30 minutes, water (343 g) was added slowly over 20 minutes. The organic layer was discarded and the aqueous layer was extracted with ethyl acetate (252 g). The organic layer was washed with 10 wt% NaCl solution (140 g) followed by 10 wt% aqueous acetic acid solution (140 g). The ethyl acetate was removed by distillation replacing the solvent with 2-propanol (319 g) for crystallization. After cooling the reaction mixture to 58°C, the mixture was seeded with product crystals and stirred at 58 °C for 1 h.
- Method C Use of lithium diisopropylamide (LDA) in THF/Hexanes.
- the solution of LDA was stirred for 30 min at 0 °C and then was added in increments to the reaction vessel containing II via syringe until the starting material had been nearly all consumed ( ⁇ 4% remaining) as judged by HPLC analysis (overall, 2.75 equivalents of LDA were added).
- the reaction was quenched with water (15 mL) and diluted with ethyl acetate. The layers were separated and the aqueous layer was determined to have a pH of 11.
- the aqueous layer was lowered to pH 8 with saturated aqueous ammonium chloride and then extracted with ethyl acetate.
- the layers were separated.
- the aqueous layer was lowered to pH 1 with 2 N HC1 and then extracted with ethyl acetate.
- Suitable solvents for use in this process step may include THF (tetrahydrofuran), DME (1,2-dimethoxyethane), ether (diethyl ether), MTBE (methyl t-butyl ether), 2-Me-THF (2-methyltetrahydrofuran), toluene, hexanes or dioxane, and mixtures thereof.
- Suitable bases for use in this process step may include lithium
- LiHMDS bis(trimethylsilyl)amide
- NaHMDS sodium bis(trimethylsilyl)amide
- KHMDS potassium bis(trimethylsilyl)amide
- LDA lithium diisopropylamide
- LTMP tetramethylpiperidide
- metal i-butoxides such as lithium i-butoxide, sodium t- butoxide, potassium i-butoxide
- metal carbonates such as lithium carbonate, sodium carbonate, potassium carbonate, cesium carbonate, and mixtures thereof.
- Suitable acids for use in this process step may include, but are not limited to, HC1, HBr, H 2 S0 4 , H 3 P0 4 , HN0 3 , acetic acid, trifluoroacetic acid, and mixtures thereof.
- This process step may be conducted at temperatures from about 150 °C to about -80 °C, or from about 100 °C to about -40 °C.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202310056673.8A CN116143750A (en) | 2016-11-18 | 2017-11-17 | Compound and preparation method thereof |
CN201780071206.5A CN110267946A (en) | 2016-11-18 | 2017-11-17 | 4- ((6- (2- (2,4 difluorobenzene base) -1,1- two fluoro- 2- hydroxyl -3- (5- sulfydryl -1H-1,2,4- triazol-1-yl) propyl) pyridin-3-yl) oxygroup) benzonitrile and preparation method |
US16/462,199 US10787431B2 (en) | 2016-11-18 | 2017-11-17 | 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation |
BR112019009759A BR112019009759A2 (en) | 2016-11-18 | 2017-11-17 | 4 - ((6- (2- (2,4-difluorophenyl) -1,1-difluoro-2-hydroxy-3- (5-mercapto-1h-1,2,4-triazol-1-yl) propyl) pyridin-3-yl) oxy) benzonitrile and preparation processes |
EP17871134.7A EP3541797A4 (en) | 2016-11-18 | 2017-11-17 | 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1h |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662423854P | 2016-11-18 | 2016-11-18 | |
US62/423,854 | 2016-11-18 |
Publications (1)
Publication Number | Publication Date |
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WO2018094138A1 true WO2018094138A1 (en) | 2018-05-24 |
Family
ID=62145720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2017/062149 WO2018094138A1 (en) | 2016-11-18 | 2017-11-17 | 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1h-1,2,4-triazol-1-yl) propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation |
Country Status (5)
Country | Link |
---|---|
US (1) | US10787431B2 (en) |
EP (1) | EP3541797A4 (en) |
CN (2) | CN116143750A (en) |
BR (1) | BR112019009759A2 (en) |
WO (1) | WO2018094138A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020020813A1 (en) | 2018-07-25 | 2020-01-30 | Bayer Aktiengesellschaft | Fungicidal active compound combinations |
EP3541795A4 (en) * | 2016-11-18 | 2020-04-29 | Dow AgroSciences LLC | 4-((6-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3(5-mercapto-1h-1,2,4-triazol-1-yl) propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120088664A1 (en) * | 2009-06-18 | 2012-04-12 | Basf Se | Antifungal 1,2,4-triazolyl derivatives having a 5-sulfur subtituent |
WO2012177635A1 (en) * | 2011-06-19 | 2012-12-27 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
US20130005985A1 (en) * | 2010-03-16 | 2013-01-03 | Basf Se | Process Using Grignard Reagents |
WO2015143188A1 (en) * | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and proceses for their preparation |
US20160102072A1 (en) * | 2013-05-28 | 2016-04-14 | Viamet Pharmaceuticals, Inc. | Fungicidal compositions |
WO2016187201A2 (en) * | 2015-05-18 | 2016-11-24 | Viamet Pharmaceuticals, Inc. | Antifungal compounds |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2890228T3 (en) * | 2016-11-18 | 2022-01-18 | Corteva Agriscience Llc | 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1H-1,2,4-triazol-1-yl)propyl) Pyridin-3-yl)oxy)benzonitrile and preparation processes |
-
2017
- 2017-11-17 WO PCT/US2017/062149 patent/WO2018094138A1/en unknown
- 2017-11-17 US US16/462,199 patent/US10787431B2/en active Active
- 2017-11-17 CN CN202310056673.8A patent/CN116143750A/en active Pending
- 2017-11-17 EP EP17871134.7A patent/EP3541797A4/en not_active Withdrawn
- 2017-11-17 CN CN201780071206.5A patent/CN110267946A/en active Pending
- 2017-11-17 BR BR112019009759A patent/BR112019009759A2/en unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120088664A1 (en) * | 2009-06-18 | 2012-04-12 | Basf Se | Antifungal 1,2,4-triazolyl derivatives having a 5-sulfur subtituent |
US20130005985A1 (en) * | 2010-03-16 | 2013-01-03 | Basf Se | Process Using Grignard Reagents |
WO2012177635A1 (en) * | 2011-06-19 | 2012-12-27 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
US20160102072A1 (en) * | 2013-05-28 | 2016-04-14 | Viamet Pharmaceuticals, Inc. | Fungicidal compositions |
WO2015143188A1 (en) * | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and proceses for their preparation |
WO2016187201A2 (en) * | 2015-05-18 | 2016-11-24 | Viamet Pharmaceuticals, Inc. | Antifungal compounds |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3541795A4 (en) * | 2016-11-18 | 2020-04-29 | Dow AgroSciences LLC | 4-((6-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3(5-mercapto-1h-1,2,4-triazol-1-yl) propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation |
WO2020020813A1 (en) | 2018-07-25 | 2020-01-30 | Bayer Aktiengesellschaft | Fungicidal active compound combinations |
Also Published As
Publication number | Publication date |
---|---|
CN116143750A (en) | 2023-05-23 |
EP3541797A1 (en) | 2019-09-25 |
EP3541797A4 (en) | 2020-04-29 |
CN110267946A (en) | 2019-09-20 |
BR112019009759A2 (en) | 2019-08-13 |
US10787431B2 (en) | 2020-09-29 |
US20190276431A1 (en) | 2019-09-12 |
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