WO2018090840A1 - 一种应用于代谢性疾病的光治疗装置及方法 - Google Patents

一种应用于代谢性疾病的光治疗装置及方法 Download PDF

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WO2018090840A1
WO2018090840A1 PCT/CN2017/109240 CN2017109240W WO2018090840A1 WO 2018090840 A1 WO2018090840 A1 WO 2018090840A1 CN 2017109240 W CN2017109240 W CN 2017109240W WO 2018090840 A1 WO2018090840 A1 WO 2018090840A1
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phototherapy
light
flexible panel
treatment
light source
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PCT/CN2017/109240
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English (en)
French (fr)
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洪洋
刘木清
陈天然
李英华
胡晓剑
杨恭
王明海
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上海市第五人民医院
复旦大学
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Publication of WO2018090840A1 publication Critical patent/WO2018090840A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0632—Constructional aspects of the apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light
    • A61N2005/0663—Coloured light

Definitions

  • the present invention relates to the field of medical device technology, and in particular to a light therapy device and method for use in metabolic diseases.
  • Metabolic diseases include hyperthyroidism, hyperparathyroidism, diabetes, kidney disease, orthopedic diseases, etc.
  • the more common treatments include drug therapy and surgical therapy.
  • these treatment methods have the disadvantages of inconvenient use, high medical cost, and large side effects.
  • LEDs Light Emitting Diodes
  • the LED device has attracted the attention of various new light sources in recent years. Thanks to its long life, compact structure, simple control, wide spectral coverage and natural light source, the LED device not only shines in general lighting applications, but also has great potential in display, agriculture and medical applications. ,bright future.
  • the current application directions mainly include: LED red light and infrared light band applied to the skin medical field of female stretch marks, surgical wounds and tissue healing, facial acne, etc.; LED blue light is used to treat seasonal depression (Seasonal Affective Disorder, SAD), periodontal disease, etc.
  • SAD Seasonal Affective Disorder
  • some light treatment devices have appeared, for example, Chinese Patent Publication No. CN200510082164.4, published on Dec.
  • a dental illumination system comprising an adjustable self-supporting frame and a base, the base coupled to the frame
  • the lamp cap includes a casing and a barrier body having a structure, and the barrier body is adapted to mechanically detachably couple the lamp cap and a reference device to facilitate the use of the light source disposed in the lamp cap to the tooth Performing illumination;
  • the barrier body and the lamp cap can be made in one piece; if the two components are separately manufactured, the lamp cap and each of the barrier bodies can have some structures;
  • the lamp system includes at least one light source, which is Selected from a group of light sources, including a halogen bulb, a semiconductor light emitting device, a light emitting chip, an LED array, a fluorescent tube, and a combination thereof;
  • a semiconductor narrow spectrum gynecological disease treatment instrument comprises a host and a treatment head, and the host computer is composed of a control system, a power system and a cooling system.
  • the treatment head is a cylindrical energy collecting treatment head which is assembled by a light guide cover, a condensing mirror, a semiconductor light source, a light source cooler, and a mounting bracket in a front-to-back order to form a spherical head.
  • the treatment head is also a head which is assembled from the front to the rear by the light guide cover, the semiconductor light-emitting tube and the mounting bracket.
  • the scattering treatment head of the spherical cylinder is connected with the host through the light source electrode, and the mounting bracket arranges the light source evenly around the bracket, and the light source output from the light source electrode has a length of 600-650 nm.
  • a semiconductor light-emitting diode light therapy device that is strong, effective, and easy to use.
  • a first object of the present invention is to provide a phototherapy apparatus for use in metabolic diseases in view of the deficiencies in the prior art.
  • a phototherapy device for use in a metabolic disease is provided with a flexible panel, the flexible panel is annular, and is provided with a notch, and the inner wall of the flexible panel is arranged in an array.
  • the semiconductor light emitting diode has a control unit integrated device on the outer wall of the flexible panel, and the two ends of the flexible panel are provided with matching fixing bands.
  • the flexible panel is annular or elliptical in shape without external force.
  • the flexible panel is a flexible rubber sheet.
  • the semiconductor light emitting diode adopts a PWM pulse driving method.
  • the semiconductor light emitting diode emits ultraviolet light, blue light, yellow green light, orange red light or a combination of two or more of the above light colors.
  • the fixing strap is a strap, a hook and a hook or a length adjustable Japanese buckle.
  • the metabolic diseases are hyperthyroidism, hyperparathyroidism, type I diabetes, type II diabetes, gestational diabetes, chronic kidney disease, fracture or osteoporosis.
  • a phototherapy method for a metabolic disease being selected from any one of the following:
  • a phototherapy device according to any of the above to provide optical therapy for a diabetic case, the light source of the phototherapy being a blue LED having a peak wavelength of 430 nm;
  • a phototherapy device according to any of the above to provide optical treatment for hyperthyroidism, the light source of the phototherapy being a blue LED having a peak wavelength of 430 nm;
  • the phototherapy device as described above to the optical treatment of severely reduced bone mass, the light source of the phototherapy being a blue LED having a peak wavelength of 430 nm;
  • d) Applying a phototherapy device as described above to the optical therapy of a case of chronic kidney disease, the source of phototherapy being a blue LED having a peak wavelength of 430 nm.
  • LED light has a good therapeutic effect on a series of metabolic diseases, and based on this, a corresponding light therapy device is designed;
  • the shape design of the light therapy device and the design of the semiconductor light emitting diode arrangement method of the invention are very reasonable, and some metabolic diseases such as hyperthyroidism and partial osteoporosis of the knee can be given, and the targeted treatment is stronger, and the treatment effect is more prominent. ;
  • the light treatment device of the invention has a variable shape, is convenient to wear, can be adjusted, and can be applied to different patients or different patient parts;
  • the semiconductor light-emitting diode adopts the PWM pulse driving mode to ensure the temperature rise safety of the light treatment device of the invention under the premise of ensuring the therapeutic effect;
  • the inventors of the present application have obtained intensive and extensive research and obtained the most suitable light therapy method for diabetes, hyperthyroidism, severe bone loss and chronic kidney disease cases.
  • Figure 1 is a schematic view showing the structure of a phototherapy apparatus of the present invention.
  • FIG. 2 is a waveform diagram of a PWM pulse driving method of a semiconductor light emitting diode.
  • Embodiment 1 Phototherapy apparatus of the present invention
  • FIG. 1 is a schematic structural view of a phototherapy apparatus of the present invention.
  • the phototherapy device is provided with a flexible panel 1 which is annular in shape and has a wearing notch 2 under natural external force.
  • a semiconductor light emitting diode 3 is disposed on the inner wall of the flexible panel 1, and the semiconductor light emitting diodes 3 are arranged in an array.
  • a control unit integration device 4 is provided on the outer wall of the flexible panel 1. Both ends of the flexible panel 1 are provided with matching straps 5 that match each other.
  • FIG. 2 is a schematic diagram of a waveform of a PWM pulse driving mode of a semiconductor light emitting diode. Due to the limitation of LED heat dissipation technology, the temperature rise of the LED driven by the constant current mode is severe, resulting in the surface temperature of the phototherapy device far exceeding the safety upper limit temperature stipulated by the relevant national regulations under a certain output optical power density. The use of PWM pulse drive can effectively solve this problem.
  • the pulse period frequency can be set higher than the human eye fusion frequency as needed, so that the patient feels the same for the output light in the two driving modes. Under the current pulse signal, the peak optical power density of the phototherapy device is not lower than the average optical power density output value in the constant current driving mode to ensure the same or even better therapeutic effect.
  • a low duty cycle mode can be used, that is, a state that is actually inactive for a long time in one cycle (within the time period t2), which greatly reduces the heat dissipation requirement of the device.
  • the flexible panel 1 is a flexible deformable structure which is annular under natural external force and is provided with a notch 2 so that it can be fixed in different patient parts such as the neck and the knee.
  • the optical treatment can be well matched with the treatment site of the patient, and the target is stronger and the treatment effect is more prominent.
  • the ring shape may be an annular shape or an elliptical shape.
  • the material of the flexible panel 1 includes, but is not limited to, a flexible rubber sheet.
  • the semiconductor light-emitting diodes 3 are arranged in an array, so that the illumination given to the patient's part is uniform to enhance the therapeutic effect.
  • the control unit integration device 4 is used to control parameters such as illumination time, illumination intensity and driving mode of the semiconductor light-emitting diode 3.
  • the fixing strap 5 is used for fixing the phototherapy device of the present invention to a patient's part, such as a neck or a knee, and the fixing strap 5 may be a strap, a hook and a hook, and a length adjustable Japanese buckle. Easy to adjust, it can be applied to different patients and different patient parts.
  • its spectral composition, light-emitting intensity, light-emitting angle, driving mode, etc. can be flexibly depending on the treatment scene; its spectral components are not limited, including but not limited to ultraviolet light, blue light, yellow-green light, orange red light, and the above-mentioned light color.
  • the respective light source emits continuous form, or transmitted in pulse form; which light intensity is not limited, by the average irradiance according to the skin surface can be flexibly changed, in particular 0mW / cm 2 to 100mW / cm 2; which light The angle is not limited, including a very narrow exit beam angle for spot illumination and a wider exit beam angle for large area illumination.
  • the light treatment device of the invention has simple overall structure, strong portability, convenient use, and can emit a light group with a certain intensity and wavelength with therapeutic effect, and provides comfortable and safe treatment for some patients with metabolic diseases, and the metabolic class used for the treatment thereof.
  • Diseases include, but are not limited to, hyperthyroidism, parathyroidism, type I diabetes, type 2 diabetes, gestational diabetes, chronic kidney disease, fractures, osteoporosis, and various metabolic diseases that are currently not precisely defined.
  • the light source of group A receiving phototherapy is ultraviolet LED with peak wavelength of 340 nm
  • the light source of group B receiving phototherapy is blue LED with peak wavelength of 430 nm
  • the light source of group C receiving phototherapy is red LED with peak wavelength of 635 nm.
  • the patient's random blood glucose concentration averaged 17.5 mmol/L
  • the fasting blood glucose concentration averaged 9.8 mmol/L.
  • the randomized blood glucose concentration of group A patients was 14.9 mmol/L
  • the fasting blood glucose concentration was 8.4 mmol/L.
  • the randomized blood glucose concentration of group B patients was 12.8 mmol/L.
  • the fasting blood glucose concentration was 7.5mmol/L; the random blood glucose concentration in group C was 17.3mmol/L, and the fasting blood glucose concentration was 9.5mmol / L, it can be seen that the treatment effect of group B is optimal.
  • patients in group A and group B also generally expressed dizziness, and the quality of sleep improved, while group C did not. Therefore, the significant improvement of each characterization index proves the therapeutic effectiveness of optical therapy for diabetes, a metabolic disease, and the therapeutic effect of blue LED is optimal.
  • the light source of group A receiving phototherapy is ultraviolet LED with peak wavelength of 340 nm
  • the light source of group B receiving phototherapy is blue LED with peak wavelength of 430 nm
  • the light source of group C receiving phototherapy is red LED with peak wavelength of 635 nm.
  • the patient's total T3 concentration was 3.75nmol/L
  • the total T4 concentration was 185nmol/L
  • the free T3 concentration was 13.53pmol/L
  • the free T4 concentration was 28pmol/L. .
  • the mean total T3 concentration in group A was 3.13 nmol/L
  • the mean total T4 concentration was 166 nmol/L
  • the mean free T3 concentration was 11.77 pmol/L.
  • the average free T4 concentration was 23 pmol/L
  • the mean total T3 concentration of the patients in group B was 2.84 nmol/L
  • the average total T4 concentration was 154 nmol/L
  • the average free T3 concentration was 10.64 pmol/L.
  • the average concentration was 22 pmol/L; the average T3 concentration in group C was 3.64 nmol/L, the average T4 concentration was 179 nmol/L, the average free T3 concentration was 13.28 pmol/L, and the mean free T4 concentration.
  • the treatment effect of group B is optimal.
  • patients in group A and group B also generally expressed hand tremor, hyperhidrosis, palpitations, emotional irritability, and polyphagia, while only some patients in group C had similar feelings. Therefore, the significant improvement of each characterization index proves the therapeutic effectiveness of optical therapy for hyperthyroidism, a metabolic disease, and the therapeutic effect of blue LED is optimal.
  • the light source of group A receiving phototherapy is ultraviolet LED with peak wavelength of 340nm
  • the light source of group B receiving phototherapy is blue LED with peak wavelength of 430nm
  • the light source of group C receiving phototherapy is red LED with peak wavelength of 635nm
  • the other 60 cases The unirradiated group was used as a control. After an optical course of 45 minutes per day for a period of 6 months, the average bone loss was 38% in the unirradiated group and 23% in the irradiated group.
  • the B group had the lowest bone loss rate.
  • patients in the irradiated group also generally expressed a reduction in back pain and improved sleep quality.
  • Optical therapy was given to 24 cases of chronic kidney disease. Among them, 12 cases were irradiation groups, which were divided into three groups of 4 people each.
  • the light source of group A receiving phototherapy is ultraviolet LED with peak wavelength of 340nm
  • the light source of group B receiving phototherapy is blue LED with peak wavelength of 430nm
  • the light source of group C receiving phototherapy is red LED with peak wavelength of 635nm
  • the unirradiated group was used as a control.
  • the average glomerular filtration rate of the patients in the non-irradiated group was 58 ml ⁇ min-1 ⁇ 1.73 m 2
  • the average glomerular filtration of the patients in the irradiation group The rate of the reaction was 89 ml ⁇ min-1 ⁇ 1.73 m 2
  • the average glomerular filtration rate of the group B was the highest.

Abstract

一种应用于代谢性疾病的光治疗装置及方法。该光治疗装置设有环状的柔性面板（1），且设有佩戴缺口（2），柔性面板（1）的内壁上设有呈阵列状排布的半导体发光二极管（3），外壁上设有控制单元集成装置（4），两端设有相互匹配的固定带（5），半导体发光二极管（3）采用的是PWM脉冲驱动方式，发出的是紫外光、蓝光、黄绿光、橙红光或上述两种或两种以上光色的组合。该光治疗方法是针对糖尿病、甲亢、骨量严重减少及慢性肾病病例以峰值波长为430nm的蓝光LED光疗。

Description

一种应用于代谢性疾病的光治疗装置及方法 技术领域
本发明涉及医疗器械技术领域，具体地说，涉及一种应用于代谢性疾病的光治疗装置及方法。
背景技术
人体代谢性疾病的机理研究与治疗方案探索一直是医疗领域的研究热门。代谢性疾病包括甲亢、甲旁亢、糖尿病、肾病、骨科类疾病等，目前其较为常见的治疗措施有药物疗法、手术疗法等。然而这些治疗方法存在使用不便、医疗成本较高、副作用较大的缺陷。
半导体发光二极管(Light Emitting Diode，LED)近年来在各种新光源中最受关注。由于LED器件本身具有安全长寿、结构紧凑、控制简便、光谱覆盖广以及属于自然舒适的冷光源等特点，使得其不仅在通用照明应用领域大放异彩，更在显示、农业以及医疗应用领域潜力巨大，前景广阔。在医疗领域，目前的应用方向主要包括：LED红光及红外光部分波段应用于女性妊娠纹、手术伤口与组织愈合、面部痤疮等的皮肤医疗领域；LED蓝光用于治疗季节性忧郁症(Seasonal Affective Disorder，SAD)、牙周疾病等。与之相应地出现了一些光治疗装置，例如中国专利文献CN200510082164.4，公开日2006.11.29，公开了一种牙科光照系统，其包括一可调节的自支持构架和一灯头，灯头联接到构架上；灯头包括一罩壳和一带有一些结构体的挡隔体，挡隔体适于将灯头与一基准装置在机械上可拆分地联接起来，以便于利用设置在灯头中的光源对牙齿执行光照；挡隔体和灯头可被制成一体；如果两部件是单独制出的，则灯头和各挡隔体上可都带有一些结构体；所述灯具系统包括至少一个光源，其是从一组光源中选出的，这一组光源包括卤素灯泡、半导体发光器件、发光芯片、LED阵列、荧光灯管以及它们的组合体；中国专利文献CN200910063623.2，公开日2011.03.30，公开了一种半导体窄光谱妇科疾病治疗仪，包括主机和治疗头两部分，主机由控制系统、电源系统、冷却系统三部分组成，治疗头是一种由导光罩、聚光镜、半导体光源、光源冷却器、安装支架按照从前至后的次序装配构成头部呈圆球形的圆柱体聚能治疗头，聚能治疗头与主机之间通过光源电极及冷却水管相连，光源电极输出的光源的长为600-650nm；所述治疗头同时也是一种从前至后依次由导光罩、半导体发光管、安装支架装配构成的头部呈圆球形的圆柱体的散射治疗头，散射治疗头与主机之间通过光源电极相连，安装支架将光源在支架周围均匀分条状排列安装，光源电极输出的光源的长为600-650nm。
然而，针对一些代谢性疾病如甲亢、膝盖部分骨质疏松等，目前并未见治疗针对性 强、效果突出、便于使用的半导体发光二极管光治疗装置。
发明内容
本发明的第一目的是针对现有技术中的不足，提供一种应用于代谢性疾病的光治疗装置。
本发明再一的目的是，提供一种代谢性疾病的光治疗方法。
为实现上述第一个目的，本发明采取的技术方案是：
一种应用于代谢性疾病的光治疗装置，所述的光治疗装置设有柔性面板，所述的柔性面板为环状，且设有佩戴缺口，柔性面板的内壁上设有呈阵列状排布的半导体发光二极管，柔性面板的外壁上设有控制单元集成装置，柔性面板的两端设有相互匹配的固定带。
所述的柔性面板在无外力作用下为圆环状或椭环状。
所述的柔性面板为柔性橡胶板。
所述的半导体发光二极管采用的是PWM脉冲驱动方式。
所述的半导体发光二极管发出的是紫外光、蓝光、黄绿光、橙红光或上述两种或两种以上光色的组合。
所述的固定带是系带、粘扣和勾扣或长度可调的日字扣。
所述的代谢性疾病为甲亢、甲旁亢、I型糖尿病、II型糖尿病、妊娠糖尿病、慢性肾脏病、骨折或骨质疏松。
为实现上述第二个目的，本发明采取的技术方案是：
一种代谢性疾病的光治疗方法，所述的光治疗方法选自下列中的任一种：
a)应用如上任一所述的光治疗装置给予糖尿病病例光学治疗，光疗的光源为峰值波长为430nm的蓝光LED；
b)应用如上任一所述的光治疗装置给予甲亢病例光学治疗，光疗的光源为峰值波长为430nm的蓝光LED；
c)应用如上所述的光治疗装置给予骨量严重减少病例光学治疗，光疗的光源为峰值波长为430nm的蓝光LED；
d)应用如上所述的光治疗装置给予慢性肾病病例光学治疗，光疗的光源为峰值波长为430nm的蓝光LED。
本发明优点在于：
1、本申请的发明人首次发现了LED光对一系列代谢性疾病具有良好的治疗效果，并基于此设计了相应的光治疗装置；
2、本发明的光治疗装置形状设计以及半导体发光二极管排布方式的设计都十分合理，可给予一些代谢性疾病如甲亢、膝盖部分骨质疏松等光学治疗，针对性更强，治疗效果更突出；
3、本发明的光治疗装置形状可变，方便佩戴，可调节，能适用于不同患者或不同病患部位；
4、半导体发光二极管采用PWM脉冲驱动方式，在保证治疗效果的前提下，确保了本发明光治疗装置的温升安全性；
5、本申请发明人经过深入而广泛的研究，获得了针对糖尿病、甲亢、骨量严重减少及慢性肾病病例最合适的光治疗方法。
附图说明
附图1是本发明的光治疗装置结构示意图。
附图2是半导体发光二极管的PWM脉冲驱动方式的波形示意图。
具体实施方式
下面结合附图对本发明提供的具体实施方式作详细说明。
附图中涉及的附图标记和组成部分如下所示：
1.柔性面板          2.佩戴缺口
3.半导体发光二极管  4.控制单元集成装置
5.固定带
实施例1 本发明的光治疗装置
请参见图1，图1是本发明的光治疗装置结构示意图。所述的光治疗装置设有柔性面板1，在自然无外力作用下所述的柔性面板1为环状，且设有佩戴缺口2。柔性面板1的内壁上设有半导体发光二极管3，所述的半导体发光二极管3呈阵列状排布。柔性面板1的外壁上设有控制单元集成装置4。柔性面板1的两端设有相互匹配的固定带5。
请参见图2，图2是半导体发光二极管的PWM脉冲驱动方式的波形示意图。由于LED散热技术条件的限制，采用恒流方式驱动的LED温升严重，导致在一定的输出光功率密度下光治疗装置的表面温度远超国家相关条例规定的安全上限温度。而采用PWM脉冲驱动则可以有效解决此问题。根据需要，可以将脉冲周期频率设置为高于人眼融合频率，使得患者对两种驱动方式下的输出光感受相同。在该电流脉冲信号下，光治疗装置的峰值光功率密度不低于恒流驱动方式下的平均光功率密度输出值，以保证产生同样甚至更优的治疗效果。同时，可采用低占空比的方式，即在一个周期中实际有很长时间处于不工作的状态(t2时间段内)，这极大地降低了器件的散热要求。
需要说明的是，所述的柔性面板1为柔性可形变结构，其在自然无外力作用下为环状，且设有佩戴缺口2，因此可固定在不同的病患部位例如颈部与膝部进行光学治疗，能很好地和患者的治疗部位相贴合，针对性更强，治疗效果更加突出。所述的环状可以是圆环状或椭环状。所述的柔性面板1其材质包含但不限于柔性橡胶板。所述的半导体发光二极管3呈阵列排布，因此对病患部位给予的光照均匀，以提升治疗效果。所述的控制单元集成装置4用于控制半导体发光二极管3的照射时间、照射强度和驱动方式等参数。所述的固定带5用于将本发明的光治疗装置固定于病患部位，如脖颈部位或膝盖部位，固定带5可以是系带、粘扣和勾扣以及长度可调的日字扣等，方便调节，可适用于不同患者以及不同病患部位。
针对半导体发光二极管3，其光谱成分、出光强度、出光角度、驱动模式等可灵活取决于治疗场景；其光谱成分不受限，包含但不限于紫外光、蓝光、黄绿光、橙红光及上述光色之有机组合，其中所述紫外光在280nm至435nm的波长范围中的波长处具有光谱峰，所述单色蓝光在435nm至500nm的波长范围中的波长处具有光谱峰，所述黄绿光在500nm至600nm的波长范围中的波长处具有光谱峰，所述橙红光在600nm至780nm的波长范围中的波长处具有光谱峰；其驱动模式也并不限于本实施例，包含恒流驱动与PWM脉冲驱动方式，相应的，光源以连续形式发射，或以脉冲形式发射；其出光强度不限，受照皮肤表面的平均辐照度可以灵活变化，具体为0mW/cm2至100mW/cm2；其出光角度不限，包含极窄的出射光束角用于定点照射，以及较宽的出射光束角用于大面积照射。
本发明的光治疗装置整体结构简单，便携性强，使用方便，可发出具有治疗效果的一定强度和波长的光组，为一些代谢性疾病患者提供舒适安全的治疗，其所用于治疗的代谢类疾病包括但不局限于甲亢、甲旁亢、I型糖尿病、II型糖尿病、妊娠糖尿病、慢性肾脏病、骨折、骨质疏松，还包含目前未准确定义的各种代谢类疾病。
实施例2 应用本发明的光治疗装置治疗糖尿病
将30例糖尿病病例分为三组，每组10人，应用本发明的光治疗装置给予光学治疗。A组接受光疗的光源为峰值波长为340nm的紫外LED，B组接受光疗的光源为峰值波长为430nm的蓝光LED，C组接受光疗的光源为峰值波长为635nm的红光LED。在接受光疗照射之前，病患的随机血糖浓度平均值为17.5mmol/L，空腹血糖浓度平均值为9.8mmol/L。在周期为14天，每天30分钟的光学疗程后，A组病患的随机血糖浓度为14.9mmol/L，空腹血糖浓度为8.4mmol/L；B组病患的随机血糖浓度为12.8mmol/L，空腹血糖浓度为7.5mmol/L；C组病患的随机血糖浓度为17.3mmol/L，空腹血糖浓度为 9.5mmol/L，可见B组治疗效果最优。此外，A组与B组病患也普遍表示头晕现象缓解，睡眠质量好转，而C组则无。因此，各表征指标的显著改善证明了光学疗法对糖尿病这一代谢性疾病的治疗有效性，且蓝光LED的治疗效果最优。
实施例3 应用本发明的光治疗装置治疗甲亢
将18例甲亢病例分为三组，每组6人，给予光学治疗。A组接受光疗的光源为峰值波长为340nm的紫外LED，B组接受光疗的光源为峰值波长为430nm的蓝光LED，C组接受光疗的光源为峰值波长为635nm的红光LED。在接受光疗照射之前，病患的总T3浓度平均值为3.75nmol/L，总T4浓度平均值为185nmol/L，游离T3浓度平均值为13.53pmol/L，游离T4浓度平均值为28pmol/L。在周期为30天，每天20分钟的光学疗程后，A组病患的总T3浓度平均值为3.13nmol/L，总T4浓度平均值为166nmol/L，游离T3浓度平均值为11.77pmol/L，游离T4浓度平均值为23pmol/L；B组病患的总T3浓度平均值为2.84nmol/L，总T4浓度平均值为154nmol/L，游离T3浓度平均值为10.64pmol/L，游离T4浓度平均值为22pmol/L；C组病患的总T3浓度平均值为3.64nmol/L，总T4浓度平均值为179nmol/L，游离T3浓度平均值为13.28pmol/L，游离T4浓度平均值为27pmol/L，可见B组治疗效果最优。此外，A组与B组病患也普遍表示手颤、多汗、心悸、情绪易激动、多食现象有所缓解，而C组仅有部分病患有类似感受。因此，各表征指标的显著改善证明了光学疗法对甲亢这一代谢性疾病的治疗有效性，且蓝光LED的治疗效果最优。
实施例4 应用本发明的光治疗装置治疗骨质疏松
对于100例骨量严重减少病例(T值在-2.0到-2.5之间)给予光学治疗。其中60例为照射组，分为三组，每组20人。A组接受光疗的光源为峰值波长为340nm的紫外LED，B组接受光疗的光源为峰值波长为430nm的蓝光LED，C组接受光疗的光源为峰值波长为635nm的红光LED，而另60例为未照射组以作为对照。在接受周期为6个月，每天45分钟的光学疗程后，未照射组病患的平均骨量流失为38％，照射组病患的平均骨量流失为23％。具体的，在照射组中，B组的骨量流失率最低。此外，被照射组的病患也普遍表示腰酸背疼现象减轻，睡眠质量好转。
实施例5 应用本发明的光治疗装置治疗慢性肾病
对于24例慢性肾病病例给予光学治疗。其中12例为照射组，分为三组，每组4人。A组接受光疗的光源为峰值波长为340nm的紫外LED，B组接受光疗的光源为峰值波长为430nm的蓝光LED，C组接受光疗的光源为峰值波长为635nm的红光LED，而另12例为未照射组以作为对照。在接受周期为2个月，每天20分钟的光学疗程后，未照射组 病患的平均肾小球滤过率为58ml·min-1·1.73m2，照射组病患的平均肾小球滤过率为89ml·min-1·1.73m2。具体的，在照射组中，B组的平均肾小球滤过率最高。表征指标的显著改善证明了光学疗法对慢性肾病这一代谢性疾病的治疗有效性，尤其是蓝光的重要疗效。
以上所述仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员，在不脱离本发明方法的前提下，还可以做出若干改进和补充，这些改进和补充也应视为本发明的保护范围。

Claims (8)

  1. 一种应用于代谢性疾病的光治疗装置，其特征在于，所述的光治疗装置设有柔性面板，所述的柔性面板为环状，且设有佩戴缺口，柔性面板的内壁上设有呈阵列状排布的半导体发光二极管，柔性面板的外壁上设有控制单元集成装置，柔性面板的两端设有相互匹配的固定带。
  2. 根据权利要求1所述的光治疗装置，其特征在于，所述的柔性面板在无外力作用下为圆环状或椭环状。
  3. 根据权利要求1所述的光治疗装置，其特征在于，所述的柔性面板为柔性橡胶板。
  4. 根据权利要求1所述的光治疗装置，其特征在于，所述的半导体发光二极管采用的是PWM脉冲驱动方式。
  5. 根据权利要求1所述的光治疗装置，其特征在于，所述的半导体发光二极管发出的是紫外光、蓝光、黄绿光、橙红光或上述两种或两种以上光色的组合。
  6. 根据权利要求1所述的光治疗装置，其特征在于，所述的固定带是系带、粘扣和勾扣或长度可调的日字扣。
  7. 根据权利要求1所述的光治疗装置，其特征在于，所述的代谢性疾病为甲亢、甲旁亢、I型糖尿病、II型糖尿病、妊娠糖尿病、慢性肾脏病、骨折或骨质疏松。
  8. 一种代谢性疾病的光治疗方法，其特征在于，所述的光治疗方法选自下列中的任一种：
    a)应用权利要求1-7任一所述的光治疗装置给予糖尿病病例光学治疗，光疗的光源为峰值波长为430nm的蓝光LED；
    b)应用权利要求1-7任一所述的光治疗装置给予甲亢病例光学治疗，光疗的光源为峰值波长为430nm的蓝光LED；
    c)应用权利要求1-7任一所述的光治疗装置给予骨量严重减少病例光学治疗，光疗的光源为峰值波长为430nm的蓝光LED；
    d)应用权利要求1-7任一所述的光治疗装置给予慢性肾病病例光学治疗，光疗的光源为峰值波长为430nm的蓝光LED。
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