WO2018085379A3 - Dual-activity nicotinamide phosphoribosyltransferase inhibitors - Google Patents

Dual-activity nicotinamide phosphoribosyltransferase inhibitors Download PDF

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Publication number
WO2018085379A3
WO2018085379A3 PCT/US2017/059508 US2017059508W WO2018085379A3 WO 2018085379 A3 WO2018085379 A3 WO 2018085379A3 US 2017059508 W US2017059508 W US 2017059508W WO 2018085379 A3 WO2018085379 A3 WO 2018085379A3
Authority
WO
WIPO (PCT)
Prior art keywords
activity
dual
modulatory
nicotinamide phosphoribosyltransferase
nampt
Prior art date
Application number
PCT/US2017/059508
Other languages
French (fr)
Other versions
WO2018085379A2 (en
Inventor
Stephen J. Gardell
Mauro Antonio DISPAGNA
Original Assignee
Sanford Burnham Prebys Medical Discovery Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanford Burnham Prebys Medical Discovery Institute filed Critical Sanford Burnham Prebys Medical Discovery Institute
Publication of WO2018085379A2 publication Critical patent/WO2018085379A2/en
Publication of WO2018085379A3 publication Critical patent/WO2018085379A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present disclosure describes NAMPT modulatory compounds, and methods of identifying NAMPT modulatory compounds. The present disclosure also describes methods of testing NAMPT modulatory compounds for NTPase activity, cell mobility modulatory activity, and cell metastasis modulatory activity.
PCT/US2017/059508 2016-11-02 2017-11-01 Dual-activity nicotinamide phosphoribosyltransferase inhibitors WO2018085379A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662416508P 2016-11-02 2016-11-02
US62/416,508 2016-11-02

Publications (2)

Publication Number Publication Date
WO2018085379A2 WO2018085379A2 (en) 2018-05-11
WO2018085379A3 true WO2018085379A3 (en) 2018-06-28

Family

ID=62076579

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2017/059508 WO2018085379A2 (en) 2016-11-02 2017-11-01 Dual-activity nicotinamide phosphoribosyltransferase inhibitors

Country Status (1)

Country Link
WO (1) WO2018085379A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018191751A1 (en) * 2017-04-14 2018-10-18 Arizona Board Of Regents On Behalf Of The University Of Arizonia Compositions and methods for treating pulmonary fibrosis
CN109580834A (en) * 2018-12-31 2019-04-05 辰欣药业股份有限公司 Detection method in relation to substance in a kind of pharmaceutical preparation containing C14H25N4NaO11P2
CN110849997B (en) * 2019-11-29 2022-07-08 中国农业科学院蜜蜂研究所 Detection method of safflower honey and product containing safflower honey

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012150952A1 (en) * 2011-05-04 2012-11-08 Forma Tm, Llc Novel compounds and compositions for the inhibition of nampt
WO2013170191A1 (en) * 2012-05-11 2013-11-14 Genentech, Inc. Methods of using antagonists of nad biosynthesis from nicotinamide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012150952A1 (en) * 2011-05-04 2012-11-08 Forma Tm, Llc Novel compounds and compositions for the inhibition of nampt
WO2013170191A1 (en) * 2012-05-11 2013-11-14 Genentech, Inc. Methods of using antagonists of nad biosynthesis from nicotinamide

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AMICI ET AL.: "Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases", CELL CHEMICAL BIOLOGY, vol. 24, 18 May 2017 (2017-05-18), pages 553 - 564, XP055495739 *
BURGOS ET AL.: "A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT", PNAS, vol. 106, 18 August 2009 (2009-08-18), pages 13748 - 13753, XP055495738 *
BURGOS ET AL.: "Weak Coupling of ATP Hydrolysis to the Chemical Equilibrium of Human Nicotinamide Phosphoribosyltransferase", BIOCHEMISTRY, vol. 47, 30 September 2008 (2008-09-30), pages 11086 - 11096, XP055495736 *

Also Published As

Publication number Publication date
WO2018085379A2 (en) 2018-05-11

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