WO2018078420A1 - Lentille de contact permettant de déterminer la température de l'œil - Google Patents

Lentille de contact permettant de déterminer la température de l'œil Download PDF

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Publication number
WO2018078420A1
WO2018078420A1 PCT/IB2016/056472 IB2016056472W WO2018078420A1 WO 2018078420 A1 WO2018078420 A1 WO 2018078420A1 IB 2016056472 W IB2016056472 W IB 2016056472W WO 2018078420 A1 WO2018078420 A1 WO 2018078420A1
Authority
WO
WIPO (PCT)
Prior art keywords
temperature
contact lens
sensor
eye
patient
Prior art date
Application number
PCT/IB2016/056472
Other languages
English (en)
Inventor
Antonino RISTAGNO
Gian BOCHSLER
Original Assignee
Eyethink Sàrl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eyethink Sàrl filed Critical Eyethink Sàrl
Priority to PCT/IB2016/056472 priority Critical patent/WO2018078420A1/fr
Publication of WO2018078420A1 publication Critical patent/WO2018078420A1/fr

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
    • A61B5/0008—Temperature signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/6821—Eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0204—Operational features of power management
    • A61B2560/0214—Operational features of power management of power generation or supply
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0204—Operational features of power management
    • A61B2560/0214—Operational features of power management of power generation or supply
    • A61B2560/0219—Operational features of power management of power generation or supply of externally powered implanted units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0242—Operational features adapted to measure environmental factors, e.g. temperature, pollution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0242—Operational features adapted to measure environmental factors, e.g. temperature, pollution
    • A61B2560/0247—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value
    • A61B2560/0252—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value using ambient temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis

Definitions

  • the present invention concerns a contact lens for determining the eye temperature, a device comprising said contact lens and a methods related thereof. Description of related art
  • Contact lens are classically used to provide vision-correcting functionality, cosmetic enhancement or therapeutic effects. Each function is provided by a physical characteristic of the lens.
  • Wearable lens may incorporate a lens assembly having an electronically adjustable focus to augment or enhance performance of the eye with a vision corrective function.
  • a pigment incorporated into the lens can provide a cosmetic enhancement.
  • An active agent incorporated into a lens can provide a therapeutic functionality.
  • contact lens have been described as medical device for assessing a physiological parameter of a patient, such as intra ocular pressure, concentration of sugar or metabolites, or for providing temperature of the ocular surface.
  • a physiological parameter of a patient such as intra ocular pressure, concentration of sugar or metabolites, or for providing temperature of the ocular surface.
  • contact lens generally incorporate electronic sensors to detect concentrations of target particular chemicals in the tear film.
  • Contact lens with sensor embedded in the core of the lens are used for measuring the eye temperature.
  • the existing device does not provide satisfying data notably because the sensor sensitivity is biased by the eye temperature and/or the environment temperature. That is why, there is a need to provide an improved solution for measuring the eye temperature, in particular the temperature of the ocular surface, in an accurate manner.
  • One of the aim of the invention is to provide a contact lens free from or limiting the limitations of the known contact lens.
  • one aim is to provide a contact lens allowing accurate determination of the eye temperature, in particular the ocular surface of the eye.
  • a contact lens comprising a sensor system for determining the ocular surface temperature of a patient, the contact lens comprising an eye side and an exterior side, the eye side being designed for contacting the patient eye, the exterior side being designed for contacting the exterior
  • the contact lens being characterized in that the sensor system comprises at least two sensors, a temperature sensor and a reference sensor, the temperature sensor being arranged for measuring the temperature of the eye side, the reference sensor being arranged for measuring the
  • the contact lens according to the present invention comprises at least two sensors, a temperature sensor and a reference sensor.
  • Each sensor is capable of measuring a temperature on one side of the contact lens, the eye side for the temperature sensor and the exterior side for the reference sensor.
  • the temperature sensor is used for measuring the temperature of the ocular surface when the eye side of the contact lens is placed onto the eye.
  • the temperature measured by the temperature sensor is influenced by the exterior environment condition on the exterior side of the contact lens.
  • the environmental condition on the exterior side of the contact lens can modify the
  • the reference sensor aims at measuring the temperature of the exterior side of the lens to evaluate the influence of the exterior environment on the temperature measured by the temperature sensor on the eye side.
  • the temperature measured by the temperature sensor is corrected by the reference temperature provided by the reference sensor to obtain the effective temperature of the ocular surface.
  • the contact lens according to the present invention is capable of providing accurate data of the temperature of the ocular surface that takes into account the temperature of the exterior environment. [0009]
  • the temperature sensor is used for measuring the eye
  • the temperature sensor measures accurately in the variation zone of the eye temperature, classically between 31 °C and 38°C.
  • the temperature sensor can be used for continuous monitoring of the eye temperature on the eye side, for instance over 24 h, or from 1 to 7 days.
  • the temperature or the reference sensor have about 0.5°C sensitivity, preferably 0.2°C to 0.1 °C sensitivity.
  • the reference sensor is used for measuring the temperature on the exterior side of the contact lens, so as to determine the variation of the environmental condition. For instance, the reference sensor measures temperature between -40°C and +60°C.
  • the reference sensor allows tuning the temperature measured by the temperature sensor and consequently avoiding the temperature drift.
  • the reference sensor can be used for continuous monitoring of the temperature on the exterior side of the contact lens for instance over 24 h, or from 1 to 7 days.
  • the temperature sensor and the reference sensor are placed side by side in the contact lens.
  • the temperature sensor and the reference sensor are diametrically opposed in the contact lens.
  • the temperature sensor is coated with a first insulator stack comprising at least one gas layer and one polymer layer between the temperature sensor and the exterior side.
  • the first insulator stack allows isolating the temperature sensor from the exterior
  • the first insulator stack comprises at several gas layers and several polymer layers.
  • the first insulator stack can comprise alternate layers of gas and polymer.
  • the reference sensor is coated with a second insulator stack comprising at least one gas layer between the eye side and the reference sensor.
  • the second insulator stack allows isolating the reference sensor from the eye to limit the influence of the eye on the reference sensor.
  • the second insulator stack can also comprise at least one gas layers and one polymer layer.
  • the second insulator stack can comprise alternate layers of gas and polymer.
  • the first insulator stack and the second insulator stack are identical.
  • the gas layer can be made of a mixture of gas.
  • the gas layer can be an air layer, i.e. an air gap. Air gaps are known to be very efficient for thermal insulation.
  • the gas can also be made of oxygen, argon, nitrogen or mixture related thereof.
  • the polymer layer is preferably made of polymer or mixture of polymer with a low heat transfer coefficient, below 0.4 W.m "1 .K.
  • the polymer layer can comprise polyethersulfone (PES),
  • PVDF polyvinylidene fluoride
  • PI polyimide
  • the temperature sensor and/or the reference sensor is coated with a solar radiation cover.
  • the solar radiation cover allows limiting the temperature drift induced by solar radiation.
  • the cover comprises low emissivity material, for instance aluminium, brass, copper, gold, nickel.
  • the temperature sensor and/or the reference sensor is coated with a watertight film.
  • Watertight film is used for preventing water ingress in the sensor system, in particular in the reference sensor or the temperature sensor.
  • the first insulator stack coating the temperature sensor and/or the second insulator stack coating the reference sensor is coated with a watertight film
  • the solar radiation cover can cover the watertight film, said watertight film coating the first insulator stack or the second insulator stack.
  • the lens further comprises an aperture opposite the temperature sensor.
  • the aperture enables a direct contact between the tear film of the eye and the temperature sensor to improve the sensitivity of the temperature sensor.
  • the direct contact between the tear film and the sensor will increase the sensitivity of the sensor system due to the removal of the contact lens material barrier.
  • the aperture also allows increasing the transmission speed of the temperature data between the ocular surface and the temperature sensor.
  • the sensor system further comprises at least two antennas, each sensor being connected to an antenna.
  • the contact lens comprises a battery connected to the sensor system for supplying energy to the sensor system.
  • the lens further comprises an equilibrium system.
  • the equilibrium system is used for balancing the displacement of the center of gravity due to the implementation of elements in the contact lens, such as the elements of the sensor system.
  • the elements in the contact lens such as the elements of the sensor system.
  • the contact lens comprises a lower part on the eye side covered by an upper part on the exterior side, said lower part comprising a housing for receiving the sensor system.
  • the contact lens can be produced by cast moulding technology. In cast moulding, in a first step, the lower part of the contact lens with a 360° housing is moulded for receiving the sensor system. The temperature sensor and the reference sensor are seated above the corneal or limbal or scleral part of the eye. Once all the elements of the sensor system are placed, the lower part is overmoulded to create the upper part of the contact lens and complete the assembly.
  • the contact lens total diameter can vary between 14.5 to 20 mm and the central thickness can vary between 100um to 1000um.
  • the contact lens material can be hydrogel, silicone hydrogel or silicone elastomer optically clear or a mixture of these materials.
  • the contact lens can have a free central optic zone diameter of -7-8 mm where no elements, notably of the sensor system, crosses inside.
  • the contact lens according to the present invention can be used for monitoring of the eye temperature, for instance for 24 h, or over several days, for instance over 7 days.
  • the contact lens according to the present invention can also be used for diagnosing an eye disease by determining the eye temperature.
  • the invention also concerns a device for determining the ocular surface temperature of a patient, the device comprising: - At least a contact lens according to the invention;
  • a computing module connected to the sensor system for processing the temperature data providing a computed temperature
  • the computed module is in charge of processing the temperature data, i.e. temperatures measured by the temperature sensor and
  • the algorithm will analyse and treat the data to provide a computed temperature corresponding to the effective temperature of the ocular surface.
  • the computed module in particular the algorithm of the computed module, implements a correction coefficient to the measured temperature (by the temperature sensor) based on the reference temperature (from the reference sensor) to compute an effective temperature corresponding to the temperature of the ocular surface.
  • the computed module allows the conversion between the measured temperature and the effective temperature to overcome the temperature drift.
  • the correction coefficient can be based on theoretical formula, calculated with FEM analysis and verified by empirical measurements or experimental measurements.
  • the computed module can be controlled by a user to provide the computed temperature on demand, whenever the user is in need of the information.
  • the computed module can also be programmed to perform the processing automatically, i.e. self-monitoring, on a regular basis, for instance every 15 minutes or every hour.
  • the device further comprises a reader for displaying the computed temperature.
  • the reader is connected to the computing module for displaying the computed temperature.
  • the reader can further display the measured temperature from the reference sensor or the measured temperature from the temperature sensor. Temperature readings can be made on demand by a user. Alternatively, the reader can be programmed to update the computed temperature displayed on the reader on a regular basis, for instance every 15 minutes or every hour.
  • the reader can also be synchronized with the computed module so as to display the most recent computed temperature processed by the computed module or alternatively several recent computed temperatures to display the change of the eye temperature over time.
  • the device further comprises a storage unit connected to the computed module for storing temperatures data and the computed temperature.
  • the device further comprises an energy supply module, for instance a battery, for supplying energy to the contact lens via the antennas.
  • the energy supply module is connected to the antenna via a wireless connection.
  • connection between the elements of the device is either made with wire or wireless.
  • connection between the contact lens and the computing module is wireless.
  • the invention further relates to a method for determining the ocular surface temperature of a patient, the method comprising the successive steps of: a) Placing at least a contact lens according to the invention onto the eye of a patient; b) Providing at least one measured temperature with the
  • the method further comprises repeating steps a) to c) for monitoring the eye temperature of the patient over at least 24 hours.
  • the present invention aims at helping diagnosing pathologies (for instance glaucoma or vascular diseases) by providing accurate eye temperature over long duration.
  • the present invention also concerns a method for determining the interocular surface temperature of a patient, the method comprising the successive steps of: a) Placing one contact lens according to the present invention onto each eye of a patient; b) Providing at least two measured temperatures with the temperature sensor and one reference temperature with the reference sensor; c) Providing computed temperatures by processing said measured temperatures and said reference temperatures with an algorithm based method, said computed temperatures corresponding to the effective temperature of the interocular surface of the eye of the patient.
  • a temperature difference between the eyes in particular between the ocular surface of the eyes, i.e. a difference between the temperature of the right eye and the temperature of the left eye, of about 0.5°C (in absolute value) might be used to diagnose pathologies (for instance glaucoma or vascular diseases).
  • the method according to the present invention allows controlling the temperature of both eyes to help diagnosing eye pathologies.
  • the method comprises repeating steps a) to c) for monitoring the interocular temperature of the patient over at least 24 hours.
  • the terms "exterior environment” refer to the environment contacting the exterior side of the contact lens when the lens is placed onto the eye of the patient.
  • the exterior side of the lens can be in contact with the exterior environment and with the lid of the patient.
  • the reference temperature measured by the reference sensor can also be influenced by the lid when the lid contacts the exterior side of the contact lens.
  • the embodiments described for the contact lens also apply to the device according to the present invention, and to the method according to the present invention, mutatis mutandis.
  • Figure 1 shows an overview of a contact lens according to a first embodiment, the lens being placed onto a model of a human eye globe;
  • Figure 2 represents an overview of the contact lens according to the first embodiment;
  • Figure 3 represents an overview of a lower part of the contact lens according to the first embodiment;
  • Figure 4 represents a cross-section view of a contact lens according to the first embodiment
  • Figure 5 represents an enlarged cross section view of a temperature sensor of the contact lens according to the first embodiment
  • Figure 6 represents an enlarged cross section view of a reference sensor of the contact lens according to the first embodiment
  • Figures 1 to 6 represent a first embodiment of a contact lens according to the present invention. However, the present invention is not limited to this embodiment.
  • the contact lens 1 is designed for being placed onto the eye globe of a patient, as illustrated schematically in figure 1.
  • the contact lens 1 comprises an eye side 2 and an exterior side 3 as illustrated in figure 2.
  • the eye side 2 is located on the side of the contact lens 1 designed for contacting the eye globe, in particular the tear film covering the eye globe.
  • the exterior side 3 is on the opposite side of the contact lens 1.
  • the exterior side 3 is the part of the contact lens designed for contacting the exterior environment. In other words, the exterior side 3 is the part of the lens that is not in contact with the eye globe.
  • the contact lens 1 comprises a lower part 4, said lower part 4 comprising a housing 5 formed in a recess 6 of the lower part 4 as illustrated in figure 3.
  • the recess 6 is formed at 360° on the lower part, meaning that the housing 4 extends all around the lower part 4 of the contact lens 1.
  • the recess 6 is formed during the cast moulding
  • the housing is designed for receiving a sensors system 7 as illustrated in figure 4.
  • the contact lens further comprises an upper part 8 created by overmoulding the lower part 4 with the sensor system 7 received herein.
  • the sensor system 7 comprises the elements required for determining the temperature of the ocular surface of the eye.
  • the sensor system 7 comprises a temperature sensor 9 connected to a first antenna 10 (temperature sensor antenna), a reference sensor 1 1 connected to a second antenna 12 (reference sensor antenna).
  • the temperature sensor 9 and the reference sensor 1 1 are diametrically opposed on the contact lens 1 , as illustrated in figures 2 and 4.
  • the temperature sensor 9 and the reference sensor 1 1 can be side by side, for instance embedded in one element (not represented in figures 1 -6).
  • the temperature sensor 9 is coated with a first insulator stack 13 (temperature sensor insulator stack).
  • the first insulator stack 13 comprises alternate layers of gas and polymer.
  • the temperature sensor 9 is glued to the housing 5 and subsequently coated with the first insulator stack 13 comprising two polymer layers 14 of between 25 and 50 mu thick and two air gap 15 of 50 mu thick in an alternate manner.
  • a watertight layer 16 of 1 to 10 mu thick of parylene, silicon oxide (Si0 2 ) and silicon derivative is deposed around the insulator stack 14.
  • the temperature sensor 8 is located in the lower part 4 opposite to an aperture 17, for instance rectangular or circular shaped,
  • the housing 5 is covered by a solar radiation cover 18 that creates a top air gap 19 above the watertight thin film 16.
  • the solar radiation cover 18 is made of a 300 to 600 nm thick of gold, brass, copper or nickel layer.
  • the reference sensor 1 1 is glued to the solar radiation cover 18, providing one air gap on each side of the reference sensors, as illustrated in figure 5.
  • the reference sensor 9 is insulated from the eye side with an air gap and the lower part 4 of the contact lens (corresponding to the second insulator stack 20).
  • the second insulator stack can also comprises at least one polymer layer and at least one gas layer.
  • the contact lens as represented in figures 1 to 6 in a first embodiment is combined with a computing module (not represented in figures 1 to 6) to provide a device for determining the ocular temperature of a patient.
  • the temperatures provided by the sensor system of the contact lens are analysed and treated by the computed module with an algorithm based method. For instance, if the measured eye temperature is 31 °C (measured by the temperature sensor), the reference temperature is 5°C (measured by the reference sensor), then the computed module will select the corrective coefficient that correspond to the reference
  • the corrective coefficient could be +0.5 °C so that in this example, the effective

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physiology (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

L'invention concerne une lentille de contact (1) comprenant un système de capteur (7) pour déterminer la température de surface oculaire d'un patient, la lentille de contact (1) comprenant un côté œil (2) et un côté extérieur (3), le côté œil (2) étant conçu pour venir en contact avec l'œil du patient, le côté extérieur (3) étant conçu pour entrer en contact avec l'environnement extérieur ou la paupière du patient. La lentille de contact (1) est caractérisée en ce que le système de capteurs (7) comprend au moins deux capteurs, un capteur de température (9) et un capteur de référence (11), le capteur de température (9) étant agencé pour mesurer la température du côté œil (2), le capteur de référence (11) étant agencé pour mesurer la température du côté extérieur (3). L'invention porte également un dispositif comprenant la lentille de contact (1), et un procédé de détermination de la température oculaire ou interoculaire d'un patient à l'aide de la lentille de contact (1).
PCT/IB2016/056472 2016-10-27 2016-10-27 Lentille de contact permettant de déterminer la température de l'œil WO2018078420A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IB2016/056472 WO2018078420A1 (fr) 2016-10-27 2016-10-27 Lentille de contact permettant de déterminer la température de l'œil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2016/056472 WO2018078420A1 (fr) 2016-10-27 2016-10-27 Lentille de contact permettant de déterminer la température de l'œil

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WO2018078420A1 true WO2018078420A1 (fr) 2018-05-03

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108742545A (zh) * 2018-05-23 2018-11-06 周欣荣 一种接触式实时眼表温度检测装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1941829A2 (fr) * 2001-02-23 2008-07-09 Marcio Marc Aurelio Martins Abreu Mesures non invasives de substances chimiques
US20150119750A1 (en) * 2013-10-31 2015-04-30 Horng Ji Lai System for measuring and analyzing ocular temperature, receiving analyzer and methods for using the same
WO2015194391A1 (fr) * 2014-06-20 2015-12-23 ソニー株式会社 Dispositif et procédé de détection, et programme
WO2015194120A1 (fr) * 2014-06-18 2015-12-23 Sony Corporation Dispositif de détection destiné à être placé en contact avec l'oeil d'un utilisateur

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1941829A2 (fr) * 2001-02-23 2008-07-09 Marcio Marc Aurelio Martins Abreu Mesures non invasives de substances chimiques
US20150119750A1 (en) * 2013-10-31 2015-04-30 Horng Ji Lai System for measuring and analyzing ocular temperature, receiving analyzer and methods for using the same
WO2015194120A1 (fr) * 2014-06-18 2015-12-23 Sony Corporation Dispositif de détection destiné à être placé en contact avec l'oeil d'un utilisateur
WO2015194391A1 (fr) * 2014-06-20 2015-12-23 ソニー株式会社 Dispositif et procédé de détection, et programme
EP3159693A1 (fr) * 2014-06-20 2017-04-26 Sony Corporation Dispositif et procédé de détection, et programme

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108742545A (zh) * 2018-05-23 2018-11-06 周欣荣 一种接触式实时眼表温度检测装置

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