WO2018070615A1

WO2018070615A1 - Biosignal compensation apparatus and method

Info

Publication number: WO2018070615A1
Application number: PCT/KR2016/015210
Authority: WO
Inventors: 김재준; 이광묵
Original assignee: 울산과학기술원
Priority date: 2016-10-11
Filing date: 2016-12-23
Publication date: 2018-04-19
Also published as: KR20180039895A; KR101908119B1

Abstract

According to the present invention, in order to compensate for a biosignal when a biosignal such as a human heart rate is inputted through any measurement device, different amplification rates can be adjusted and applied on a real-time basis so as to correspond to the magnitudes of biosignals inputted from an amplification stage amplifying the biosignal, such that even when the magnitude of an inputted biosignal is not constant because of a problem of the biosignal measurement device, a biosignal having a magnitude of a constant level can be stably outputted.

Description

Biological signal correction device and method

The present invention relates to a device for collecting a bio-signal, and in particular, when a bio-signal, such as a human heart rate, is input through an arbitrary measuring device, different amplification corresponding to the magnitude of the bio-signal input from the amplification stage for amplifying the bio-signal. The biosignal correction apparatus and method for stably outputting a biosignal having a constant level even though the rate of the biosignal is not constant due to a problem in the biosignal measurement environment. It is about.

In general, a biosignal is a signal representing a human body state and is mainly information necessary for diagnosing a disease or a health state.

Such a biosignal includes an electrocardiogram, an electroencephalogram, an electrocardiogram, etc., which are electrical signals, and a blood pressure, a body temperature, a pulse wave, etc., which are physical signals, and various types of signals including blood sugar, oxygen saturation, body composition, etc. It may be made of.

On the other hand, electrocardiogram, electroencephalogram, electromyography, etc., which are represented as electrical signals among the above-mentioned biosignals, are generally attached to a biosignal measuring device such as a sensor made of an attachable patch on the skin, and then a signal having a high potential difference is collected. Remove and use to amplify to the extent possible (for example, Korean Patent No. 10-1483620 (registered date January 12, 2015)).

However, the electrode impedance fluctuation may be severe depending on the contact state between the skin and the adhesive patch, and as a result, the biosignal is input in an inconsistent state and thus the reliability of the biosignal is degraded. there was.

Therefore, in the present invention, when a biological signal such as a human heart rate is input through an arbitrary measuring device, different amplification rates are adjusted and applied in real time to correspond to the magnitude of the biological signal input from the amplifying stage for amplifying the biological signal. It is an object of the present invention to provide a biosignal correction apparatus and method for stably outputting a biosignal having a predetermined level even if the magnitude of the biosignal is not constant due to a problem of a biosignal measurement environment.

The present invention described above is a biosignal correction device, comprising: an amplitude adjustment unit for detecting the magnitude of a biosignal input from a biometric information measuring device and adjusting the amplification ratio of the biosignal in real time according to the magnitude of the biosignal; Amplifying unit for amplifying the bio-signal at amplification rate according to.

The amplification ratio may include a first amplification ratio and a second amplification ratio, and the amplification unit may include a first amplifying unit configured to primarily amplify the biosignal according to the first amplification ratio, and the first amplifying unit. It is connected in series, characterized in that it comprises a second amplification unit for amplifying the biological signal amplified from the first amplification unit in accordance with the second amplification rate.

The amplitude adjusting unit may further include a preamplifier configured to preamplify the input biosignal at a preset preamplification rate, a rectifier configured to rectify the preamplified biosignal to generate a rectified biosignal, and a preset DC voltage. An amplification factor for comparing the baseline signal having a level with the rectified biosignal to recognize a peak waveform of the rectified biosignal and adjusting the amplification ratio of the amplification unit so that the magnitude of the peak waveform is within a reference voltage range It characterized in that it comprises an adjustment unit.

The amplification factor adjusting unit may compare the baseline signal with the rectified biosignal to recognize the peak waveform within a section of the rectified biosignal in which a peak waveform having a voltage magnitude greater than that of the baseline signal exists. And converting a magnitude of a peak voltage of the peak waveform into a digital bit in the section, and applying an amplitude adjustment signal to the first amplifying part to control the output of the first amplifying part to be within a predetermined range based on the digital bit. When the magnitude of the final bio-signal output from the SAR-ADC unit and the second amplifying unit is out of a predetermined reference voltage range, the first amplifying rate of the first amplifying unit or the second amplifying rate of the second amplifying unit And a controller for controlling the size of the final biosignal to be included in the reference voltage range. All.

The controller may determine whether an output of the first amplifier is included in the predetermined range when the magnitude of the final biosignal is out of a predetermined reference voltage range, and the output of the first amplifier is included in the predetermined range. If not included, the first amplification ratio of the first amplification unit is adjusted by adjusting the value of the digital bit output from the SAR-ADC unit, and the output of the first amplification unit is included in the predetermined range The second amplification unit of the second amplification unit is adjusted so that the magnitude of the final biosignal is within the reference voltage range.

The correction apparatus may further include a capacitor array for smoothing the biosignal at an output of the rectifier, and the SAR-ADC unit recognizes the peak waveform value when the smoothed biosignal is reduced in magnitude. After that, the recognition operation of the peak waveform is stopped to minimize power consumption.

The amplitude adjuster may include a preamplifier configured to preamplify the input biosignal at a preset preamplification rate, and a baseline signal in a period of each biosignal based on a baseline signal having a preset DC voltage level. A SAR-ADC unit for detecting a peak waveform having a larger voltage magnitude and converting the magnitude of the peak voltage with respect to the detected peak waveform into a plurality of digital bits, and a maximum value of the plurality of digital bits applied from the SAR-ADC unit. A peak-to-peak detector for generating a digital bit subtracted from the minimum value and applying an amplitude adjustment signal to the first amplifier to control the output of the first amplifier to be within a predetermined range based on the digital bit; When the magnitude of the final biosignal output from the amplifier is outside the preset reference voltage range, first amplification of the first amplifier And a controller configured to adjust the rate or the second amplification rate of the second amplification unit to control the size of the biosignal to fall within the reference voltage range.

In addition, the reset signal is connected to the peak-to-peak detector, and generates a reset signal set to have a second period corresponding to the first period of the biosignal to control the operation of the peak-to-peak detector, and wherein the reset signal is applied. And a reset generator for controlling the amplitude adjustment signal to be applied to the first amplifier at a point in time.

The peak-to-peak detector may detect the positive edge of the reset signal applied from the reset generator and apply the amplitude adjustment signal to the first amplifier.

The present invention also provides a biosignal correction method performed by a biosignal correcting apparatus including an amplitude adjusting unit and an amplifying unit, wherein the amplitude adjusting unit receives a biosignal measured from a biometric information measuring device, and wherein the amplitude adjusting unit Detecting the magnitude of the biosignal, adjusting the amplification rate of the biosignal in real time according to the magnitude of the biosignal, and amplifying the biosignal at the amplification rate according to the adjustment by the amplification unit; .

The amplification rate may include a first amplification rate and a second amplification rate, and the amplifying step may include: amplifying the biosignal first according to the first amplification rate in a first amplifying unit in the amplifying unit; And amplifying the biosignal amplified primarily by the second amplification unit in a second amplification unit connected in series with the first amplifying unit in accordance with the second amplification rate.

The adjusting may include preamplifying the input biosignal at a predetermined preamplification rate by the amplitude adjustment unit, and generating a rectified biosignal by rectifying the preamplified biosignal at the amplitude adjustment unit. And comparing the rectified biosignal with a baseline signal having a predetermined DC voltage level in the amplitude adjusting unit to recognize a peak waveform of the rectified biosignal, and the magnitude of the peak waveform is within a reference voltage range. Characterized in that it comprises the step of controlling to.

The controlling may include: comparing the baseline signal with the rectified biosignal in the amplitude adjusting unit, and determining the peak within the section of the rectified biosignal in which a peak waveform having a voltage magnitude greater than that of the baseline signal exists. Recognizing a waveform, the amplitude adjusting unit converting the magnitude of the peak waveform into digital bits, and generating an amplitude adjusting signal for adjusting the first amplification ratio based on the digital bits; And controlling the amplitude of the peak waveform amplified at the first amplification rate to be within a predetermined range using an amplitude adjustment signal.

The method may further include: when the magnitude of the final biosignal output from the amplitude adjusting unit through the second amplification ratio is out of a predetermined reference voltage range, the first amplification ratio of the first amplification unit or the second amplification unit of the second amplification unit. And adjusting the amplification rate so that the magnitude of the final biosignal is included in the reference voltage range.

The controlling of the control unit to be included in the reference voltage range may include checking whether the output of the first amplifier is included in the predetermined range when the amplitude of the final biosignal is out of the reference voltage range. And adjusting the first amplification ratio of the first amplifier by adjusting the value of the digital bit in the amplitude adjusting unit when the output of the first amplifier is not included in the predetermined range. And when the negative output is included in the predetermined range, adjusting the second amplification rate so that the amplitude of the final biosignal is included in the reference voltage range.

The adjusting may include pre-amplifying the input biosignal at a predetermined preamplification rate by the amplitude adjusting unit and each biosignal based on a baseline signal having a predetermined DC voltage level at the amplitude adjusting unit. Detecting a peak waveform having a larger voltage magnitude than the baseline signal in a period of, and converting a magnitude of the peak voltage with respect to the detected peak waveform into a plurality of digital bits, and in the amplitude adjusting unit, a maximum value of the plurality of digital bits Generating a digital bit subtracted from the minimum value, and generating an amplitude adjustment signal for adjusting the first amplification ratio of the first amplifier based on the digital bit, and using the amplitude adjustment signal in the amplitude adjustment unit using the amplitude adjustment signal. Controlling the amplitude of the peak waveform amplified at one amplification rate to be within a predetermined range. Characterized in that it also.

The generating of the amplitude adjustment signal may include generating a reset signal set to have a second period corresponding to the first period of the biosignal by the amplitude adjustment unit, and applying the reset signal to the amplitude adjustment unit. Generating the amplitude adjustment signal at a point in time.

According to the present invention, in the biosignal correction, when a biosignal such as a human heart rate or the like is input through an arbitrary measuring device, different amplification rates are made in real time to correspond to the magnitude of the biosignal input from the amplifying stage that amplifies the biosignal. By adjusting to be applied, there is an advantage that the bio-signal having a certain level of size can be stably output even if the size of the input bio-signal is not constant due to the problem of the bio-signal measuring apparatus.

Further, in the biosignal correction according to the present invention, the first amplifier is designed to adjust the amplitude of the biosignal roughly, and in the second amplifier connected to the first amplifier, the amplitude of the biosignal is finely adjusted. Designing to be adjustable has the advantage that the amplitude of the biological signal can be corrected with high accuracy using a relatively simple structure.

In addition, in the biosignal correction according to the present invention, the amplitude of the biosignal can be corrected by itself in a circuit, and if an error of an amplitude adjustment signal for correcting the amplitude in the circuit occurs seriously, through the MCU By adjusting the amplitude adjustment signal to adjust the amplitude of the biosignal, there is an advantage of increasing the stability of the biosignal correction.

1 is a detailed circuit diagram of a biosignal correcting apparatus according to a first exemplary embodiment of the present invention.

2 is a diagram illustrating a biosignal and a baseline signal according to an embodiment of the present invention.

3 is an exemplary diagram illustrating a biosignal in which the slope of a peak voltage is adjusted and a SAR-ADC operation control signal according to an exemplary embodiment of the present invention.

4 is an exemplary view illustrating an operation of adjusting a first amplification factor in a control unit according to an embodiment of the present invention.

5 is an exemplary view illustrating an operation of adjusting a second amplification factor in a control unit according to an embodiment of the present invention.

6 is a detailed circuit diagram of a biosignal correcting apparatus according to a second exemplary embodiment of the present invention.

7 is a detailed block diagram of the peak-to-peak detection unit shown in the second embodiment of the present invention.

8A and 8B illustrate an operation of removing a DC offset from an input biosignal according to a second embodiment of the present invention.

Hereinafter, with reference to the accompanying drawings will be described in detail the operating principle of the present invention. In the following description of the present invention, when it is determined that a detailed description of a known function or configuration may unnecessarily obscure the subject matter of the present invention, the detailed description thereof will be omitted. Terms to be described later are terms defined in consideration of functions in the present invention, and may be changed according to intentions or customs of users or operators. Therefore, the definition should be made based on the contents throughout the specification.

1 illustrates a detailed circuit configuration of a biosignal correction apparatus according to a first embodiment of the present invention.

Hereinafter, an operation of each component of the biosignal compensator 100 will be described in more detail with reference to FIG. 1.

First, a differential chopping amplifier (NCA) 110 amplifies a biological signal input from a person to be measured at a constant amplitude. At this time, the bio-signals are input as differential signals such as Vin + and Vin-, and the differential amplifier 110 may amplify and output the difference between the two differential signals. In addition, such a biosignal may be input from, for example, a patch-shaped ECG sensor attached to a human skin, but is not limited thereto. In addition, the biosignal may be a human electrocardiogram signal, but is not limited thereto.

The amplifying unit 152 amplifies the input bio signal according to the amplification rate adjusted in real time by the amplitude adjusting unit 120. The amplifying unit 152 is connected in series to the first amplifying unit 140 and the first amplifying unit 140 to amplify the biosignal first according to the amplification rate, the amplified body from the first amplifying unit 140 It may include a second amplifier 150 to amplify the signal in accordance with the second amplification ratio.

The first amplifier 140 may be connected to the rear end of the differential amplifier 110, and amplifies the biosignal amplified by the differential amplifier 110 once again according to a preset first amplification rate. In this case, the first amplification ratio of the first amplifier 140 may be determined according to the amplitude adjustment signal generated by the amplitude adjuster 120. In addition, the first amplification rate is changed and adjusted in real time by the amplitude adjusting unit 120 to correspond to the size of the input biosignal, and the magnitude of the final output biosignal is adjusted according to the amplification rate adjustment of the amplitude adjusting unit 120. Regardless of the magnitude of the input biosignal, the signal may be amplified to a magnitude within a preset reference voltage range. In addition, the first amplification ratio in the first amplification unit 140 is preferably adjusted in eight steps, such as four times, six times, eight times, and the like of the input biosignal, but is not limited thereto.

The second amplification unit 150 may be connected to the rear end of the first amplification unit 140, and the first amplification unit 140 may apply the first amplification rate adjusted according to the size of the input signal to amplify the biological signal. Amplify once more according to the second preset amplification rate. In this case, the second amplification ratio of the second amplification unit 150 is determined according to the amplitude adjustment signal generated by the amplitude adjustment unit 120, and a relatively low amplification ratio is determined in comparison with the first amplification rate, so that the first amplification is performed. The amplitude of the biological signal amplified by the unit 140 is finely adjusted, and this amplification rate is preferably adjusted in eight steps, for example, 1.1 times, 1.3 times, ..., 2.5 times, etc. It is not limited to this.

The analog-digital converter (ADC) 160 converts the biosignal amplified by the first amplifier 140 and the second amplifier 150 into a digital signal and outputs the digital signal. In this case, the ADC 160 may be implemented to output, for example, a biosignal as a digital bit value of 12 bits, but is not limited thereto.

The amplitude adjusting unit 120 receives the biosignal amplified by the differential amplifier 110, detects the magnitude of the input biosignal, and inputs the biosignal to the first amplifier 140 and the second amplifier 150. The first and second amplification rates of the first and

second amplification unit

140 and 150 are adjusted in real time so that the magnitude of the final biosignal amplified by the reference signal is included within a preset reference voltage range. .

The amplitude adjuster 120 may include a pre-amplifier 122, a rectifier 124, a baseline amplifier 126, and an amplification factor adjuster 132. The amplification factor adjusting unit 132 may further include a SAR-ADC unit 128 and a controller 130. Hereinafter, the operation of each component of the amplitude adjusting unit 120 will be described in more detail.

First, the preamplifier 122 preamplifies the biosignal amplified by the differential amplifier 110 at a preset preamplification rate. In this case, the reason why the amplified bio signal amplified by the differential amplifier 110 is once again amplified by the preamplifier 122 located at the input terminal of the amplitude adjuster 120 is large. This is to prevent the amplitude adjustment unit 120 from measuring the size of the biosignal in a case where it is too small.

The baseline amplifier 126 receives the pre-amplified biosignal and filters it through a low pass filter to generate a baseline signal from which a high frequency signal of the biosignal is removed. do. That is, for example, assuming that an ECG signal of a human is input as a biosignal as shown in FIG. 2, a peak waveform 200 of the biosignal is removed through a low pass filter of the baseline amplifier 126. As shown at 202, only a horizontal voltage V_ {baseline} of constant voltage can be generated.

Subsequently, the baseline amplifier 126 adds a DC voltage of a predetermined level to the biosignal from which the peak waveform is removed as described above, and has a baseline signal V_ {baseline} + DC voltage having a DC voltage of a predetermined level. ) 204 can be generated. In this case, the DC voltage may be provided from the controller 130, but is not limited thereto.

In this case, as shown in FIG. 2, a plurality of waveforms having a relatively small size may be mixed with noise except for a peak waveform, as shown in FIG. 2. The DC signal is generated to have a constant level of DC voltage with respect to the line signal 204. Accordingly, by comparing the baseline signal 204 with the biosignal, it is possible to more accurately detect the peak waveform in the input biosignal.

The rectifier 124 rectifies the biosignal amplified from the preamplifier 122. In this case, an adjustable capacitor array 125 may be connected to an output terminal of the rectifier 124 to adjust a slope of a voltage that decreases from a point where a peak waveform of the biosignal occurs. That is, for example, a biosignal such as an electrocardiogram signal decreases the voltage value of the peak waveform so quickly that it is difficult for the SAR-ADC unit 128 to detect the correct peak waveform voltage (hereinafter referred to as peak voltage). You may not. Therefore, in the present invention, the slope of the peak voltage that decreases from the point where the peak waveform is generated through the capacitor array 125 for the biosignal rectified by the rectifier 124 is adjusted. The biosignal whose tilt is adjusted may be displayed as in reference numeral 302 of FIG.

The amplification rate adjusting unit 132 compares the baseline signal and the rectified biosignal to recognize the peak waveform of the rectified biosignal, and adjusts the amplification ratio of the amplifying unit 152 so that the magnitude of the peak waveform is controlled to a predetermined level. I can adjust it. In addition, the amplification rate adjusting unit 132 may include a SAR-ADC unit 128, a controller 130, and the like.

The SAR-ADC unit 128 receives the baseline signal 204 and the rectified biosignal from the baseline amplifier 126 and the rectifier 124, and then compares the two signals to have a voltage larger than that of the baseline signal. The peak waveform presence section of the biosignal that is enlarged is detected, and the magnitude of the peak voltage of the peak waveform present in the detected section is converted into digital bits. Also, the SAR-ADC unit 128 may apply an amplitude adjustment signal to the first amplifier 140 to control the output of the first amplifier 140 to a predetermined level based on the digital bits.

The digital bit is a value representing the magnitude of the peak voltage with respect to the peak waveform of the input biosignal. The digital bit is applied to the first amplifier 140 as an amplitude adjustment signal to amplify the biosignal by the first amplifier 140. It can be used as an element to determine. That is, the first amplification unit 140 may be implemented such that the amplification ratios of the biosignals are set differently according to the magnitudes of the peak voltages of the input biosignals. Therefore, when the magnitude value of the peak voltage of the biosignal currently input from the SAR-ADC unit 128 is converted into a digital bit, and then an amplitude adjustment signal based on the digital bit is input, the first amplifier 140 The biosignal is amplified at a first amplification rate prestored corresponding to the input amplitude adjustment signal.

At this time, when the magnitude of the peak voltage of the input biosignal is relatively small, the biosignal is amplified at a relatively high amplification rate. When the magnitude of the peak voltage of the biosignal is relatively large, the biosignal is amplified at a relatively low amplification rate. Even if an unstable biosignal is input through the first biometric signal, a biosignal having a certain level (amplitude) is output through the first amplifier 140 to obtain a stable biosignal.

Meanwhile, the SAR-ADC unit 128 as described above is a device for measuring peak voltage by detecting peak waveforms from an input biosignal. The SAR-ADC unit 128 may make an enable signal to reduce power consumption and operate only when necessary. have.

That is, as shown in FIG. 2, the peak waveform 200 of the biosignal is generated only in a portion of the waveform of the entire biosignal, and the peak voltage of the peak waveform is larger than the voltage of the baseline signal 204. Therefore, by detecting the time at which the biosignal becomes larger than the baseline signal, the enable signal for operating the SAR-ADC unit 128 is changed from the digital bit value "0" to "1", and the SAR-ADC unit 128 The enable signal may be implemented to change from "1" to "0" at the moment when the magnitude of the peak voltage of the biosignal currently input from the digital signal is converted into a digital bit. The reference numeral 300 of FIG. 3 illustrates the waveform of the enable signal of the SAR-ADC unit 128 as described above, and the SAR-ADC unit 128 operates when the waveform of the enable signal is high. By converting the peak voltage into a digital bit, the SAR-ADC unit 128 can be implemented to stop the operation when the low (low).

That is, the SAR-ADC unit 128 may be implemented to stop operation when the size of the smoothed biosignal is reduced when the biosignal is smoothed through the capacitor array 125 connected to the output terminal of the rectifier 124. have. This may minimize power consumption by operating the SAR-ADC unit 128 only for a minimum time, but is not limited thereto.

In addition, the SAR-ADC unit 128 is designed with 6 bits to reduce the power consumption, it is preferable to implement to minimize the power consumption by minimizing the number of resistors and increasing the respective resistance value using the R-2R structure, It is not limited to this.

The controller 130 checks whether the magnitudes of the bio signals output through the first amplifier 140 and the second amplifier 150 are out of a predetermined reference voltage range, and when the controller 130 is out of the reference voltage range, the first amplifier. By adjusting the amplification rate of the 140 or the second amplification unit 150, the size of the biosignal may be adjusted to be included in the reference voltage range.

That is, the controller 130 does not accurately convert the digital bits output through the SAR-ADC unit 128 to correspond to the size of the biosignal, so that the amplification ratio of the first amplification unit 140 is converted into these digital bits. If it is determined that the amplification factor is too large or too small and the output of the first amplifier 140 is not determined to be in the normal range, the digital bit value output from the SAR-ADC unit 128 is once again. By correcting the first amplification rate, the biosignal having a normal range may be output through the first amplification unit 140.

That is, for example, as shown in FIG. 4, when the reference of the biosignal output from the differential amplifier 110 is 40 mV, the magnitudes of the biosignals output from the differential amplifier 110 are 15 mV, 25 mV, If it is 35mV, the digital bits of the amplitude adjustment signal for adjusting the amplitude of the first amplifier 140 output from the SAR-ADC unit 128 when the amplitude adjustment unit 120 is operating properly, in each

case

001, 010 , 011 should be printed. However, due to the DC offset or the offset due to the internal structure of the SAR-

ADC unit

128, 010, 011, 100 may be output in each case. In this case, the target amplification rate may be increased as a whole corresponding to the size of the input biosignal, which may cause a change in the desired amplification rate. When such a problem occurs, the controller 130 receives a digital bit, which is an output of the SAR-ADC unit 128, as an input, and performs a calculation to subtract 001 entirely, and then removes the digital bit from which 001 is subtracted. The first amplification ratio can be adjusted by using the first amplification unit 140 as an amplitude adjustment signal for adjusting the first amplification ratio.

In addition, the controller 130 recognizes the magnitude of the biosignal finally output through the first amplifier 140 and the second amplifier 150 using the digital bits obtained through the ADC 160 in the final output terminal. In response to determining that the final biosignal is out of the reference voltage range, the second amplification rate may be adjusted so that the final biosignal is adjusted within the reference voltage range.

That is, for example, as shown in FIG. 5, the size of the approximate live signal is adjusted in the first amplifier 140 so that the size of the biosignal output from the first amplifier 140 is in the range of 340 mV to 480 mV. If so, the second amplifier 150 amplifies the bio-signal according to the amplitude adjustment signal from the controller 130 to adjust more accurately.

For example, the amplitude adjustment signal of the second amplifier 150 in the initial state is the digital bit value 011 (amplification ratio of the second amplifier 150 = 2 times), and is output from the first amplifier 140. When the biosignal size is 340 mV, the second amplification unit 150 may be formed at the biosignal output corresponding to the 12-bit digital bit output through the ADC 160 by the biosignal output from the second amplifying unit 150. A value obtained by dividing by an amplification factor of 2) is calculated to find a value of 340 mV which is the magnitude of the biosignal output from the first amplifier 140. Then, according to the amplitude of the biological signal output from the first amplifying unit 140, the amplitude adjustment signal of the second amplifying unit 150 is determined as, for example, a digital bit value 000 to finally obtain a constant signal size of 800 mV. The second amplification ratio of the second amplifier 150 is adjusted.

In addition, when adjusting the second amplification rate, the control unit 130 may need to adjust more precisely than the first amplification rate. Accordingly, it is necessary to design the second amplification ratio of the second amplification unit 150 in a relatively detailed manner compared to the first amplification ratio, and the ADC 160 is also relatively smaller than the SAR-ADC unit 128. It is necessary to design to enable the measurement of fine signal magnitude, but is not limited thereto.

In addition, the controller 130 may provide the baseline amplifying unit 126 with a DC voltage having a predetermined level so that the baseline signal is generated as a signal having a predetermined DC voltage level, but is not limited thereto.

6 illustrates a detailed circuit configuration of the biosignal correcting apparatus according to the second embodiment of the present invention.

Hereinafter, an operation of each component of the biosignal compensator will be described in more detail with reference to FIG. 6.

First, in the biosignal correcting apparatus according to the second exemplary embodiment, the baseline amplifier 126 is removed from the configuration of the amplitude adjusting unit 120 illustrated in the first exemplary embodiment, and the peak-to-peak connected to the SAR-ADC unit 128 is removed. A peak to peak detector 600 and a reset generator 602 may be further provided.

In the biosignal correcting apparatus of the first embodiment described above with reference to FIG. 1, the amplitude of the biosignal is measured by generating the amplitude adjustment signal by measuring the amplitude of the biosignal with an absolute value of the magnitude of the input biosignal. This may occur due to an error in the adjustment signal.

Accordingly, in the second embodiment, only the inherent amplitude value of the input biosignal from which the DC offset is removed by finding the maximum value and the minimum value in the digital bit output from the SAR-ADC unit 128 through the peak-to-peak detection unit 600 is obtained. It is possible to generate a digital bit converted to a digital value, the first amplification to amplify the input bio-signal in the first amplifier 140 by providing the digital bit is provided as an amplitude adjustment signal of the first amplifier 140 The rate can be set more accurately to correspond to the magnitude of the input biosignal.

At this time, in the second embodiment shown in FIG. 6, the capacitor array 125 connected to the output terminal of the rectifying unit 124 is removed, and the period of each biosignal is based on the baseline signal in the SAR-ADC unit 128. In the present invention, all peak waveforms having a larger magnitude than the baseline signal are detected, and the peak voltages of the detected peak waveforms are converted into a plurality of digital bits and output. Accordingly, the peak-to-peak detector 600 generates a digital bit obtained by subtracting a minimum value from a maximum value among the plurality of digital bits applied from the SAR-ADC unit 128 and based on the generated digital bits, the first amplification is performed. The amplitude adjustment signal for controlling the output of the unit 140 to a predetermined level is to be generated.

Hereinafter, operations of the peak-to-peak detector 600 and the reset generator 602 will be described in more detail.

First, the peak-to-peak detector 600 receives a plurality of digital bits converted to correspond to the magnitude of the peak voltage of the biosignal from the SAR-ADC unit 128 and subtracts the minimum value from the maximum value of the plurality of digital bits. The digital bit generated as described above represents a value obtained by digitally converting the amplitude of the biosignal from which the DC offset is removed. In addition, the digital bits generated from the peak-to-peak detector 600 are provided to the first amplifier 140 and the first amplification unit 140 sets the first amplification rate corresponding to the digital bits. The signal is amplified at the first amplification rate.

In this case, as the first amplification ratio is set based on the magnitude of the biosignal from which the DC offset is removed, the first amplification unit 140 may set a more accurate first amplification ratio corresponding to the size of the input biosignal. do.

In this case, the peak-to-peak detector 600 includes a digital maximum value detector 700, a digital minimum value detector 702, and a subtractor 704 as shown in FIG. 7. And the like. Referring to the operation of each component, the maximum value detector 700 detects the maximum value among the plurality of digital bits input from the SAR-ADC unit 128, and the minimum value detector 702 detects the SAR-ADC unit 128. The minimum value of the plurality of digital bits input from the digital signal is detected.

As described above, the maximum and minimum values detected by the maximum value detector 700 and the minimum value detector 702 are transferred to the subtractor 704 which receives the maximum and minimum values as inputs, and the subtractor 704 receives the maximum value and the minimum value. The digital bit value of the peak voltage of the biosignal from which the DC offset is subtracted may be output.

Accordingly, the peak waveform of the pure input biosignal from which the DC offset value is removed as shown in FIG. 8B is compared with the amplitude value 800 of the peak waveform of the input biosignal including the conventional DC offset shown in FIG. 8A. The amplitude value 802 may be converted into digital bits.

In addition, the digital bit converted as described above is provided to the first amplifier 140 and more accurate first amplification corresponding to the size of the input biosignal based on the digital bit from which the DC offset is removed from the first amplifier 140. The rate can be set.

The reset generator 602 generates an operation control signal for operating the peak-to-peak detector 600 to adjust an operation period of the peak-to-peak detector 600 to adjust the first amplification ratio of the first amplifier. Adjust the period to generate the amplitude adjustment signal.

That is, the reset generator 602 is connected to the peak-to-peak detector 600, for example, generates a reset signal set to have a second cycle corresponding to the first cycle of the biosignal, thereby generating the peak-to-peak detector 600. ) May be controlled, and the amplitude adjustment signal generated from the peak-to-peak detector 600 may be applied to the first amplifier 140 when the reset signal is applied.

In this case, the peak-to-peak detector 600 may be implemented to detect a positive edge of the reset signal applied from the reset generator 602 and apply the amplitude adjustment signal to the first amplifier 140. However, the present invention is not limited thereto.

As described above, according to the present invention, in the biosignal correction, when a biosignal such as a human heart rate or the like is input through an arbitrary measuring device, the amplification stage for amplifying the biosignal corresponds to each other to correspond to the magnitude of the biosignal. By adjusting and applying different amplification rates in real time, even if the size of the input biosignal is not constant due to a problem of the biosignal measuring apparatus, the biosignal having a certain level can be stably output.

Combinations of the steps of each flowchart attached to the present invention may be performed by computer program instructions. These computer program instructions may be mounted on a processor of a general purpose computer, special purpose computer, or other programmable data processing equipment such that the instructions performed through the processor of the computer or other programmable data processing equipment are described in each step of the flowchart. It will create a means to perform them. These computer program instructions may be stored in a computer usable or computer readable memory that can be directed to a computer or other programmable data processing equipment to implement functionality in a particular manner, and thus the computer usable or computer readable memory. It is also possible for the instructions stored therein to produce an article of manufacture containing instruction means for performing the functions described in each step of the flowchart. Computer program instructions may also be mounted on a computer or other programmable data processing equipment, such that a series of operating steps may be performed on the computer or other programmable data processing equipment to create a computer-implemented process to create a computer or other programmable data. Instructions for performing the processing equipment may also provide steps for executing the functions described in each step of the flowchart.

In addition, each step may represent a module, segment or portion of code that includes one or more executable instructions for executing a specified logical function (s). It should also be noted that in some alternative embodiments, the functions noted in the steps may occur out of order. For example, the two steps shown in succession may in fact be performed substantially simultaneously or the steps may sometimes be performed in the reverse order, depending on the function in question.

Meanwhile, in the above description of the present invention, specific embodiments have been described, but various modifications may be made without departing from the scope of the present invention. Therefore, the scope of the invention should be determined by the claims rather than by the described embodiments.

Claims

An amplitude adjustment unit for detecting the magnitude of the biosignal input from the biometric information measuring device and adjusting the amplification ratio of the biosignal in real time according to the magnitude of the biosignal;

An amplifier for amplifying the bio-signal at an amplification rate according to the adjustment

Biological signal correction apparatus comprising a.
The method of claim 1,

The amplification rate includes a first amplification rate and a second amplification rate,

The amplification unit,

A first amplifying unit configured to amplify the biosignal primarily according to the first amplification rate;

A second amplification unit connected in series with the first amplifying unit and configured to amplify the biosignal amplified from the first amplifying unit secondly according to the second amplification rate;

Biological signal correction apparatus comprising a.
The method of claim 1,

The amplitude adjustment unit,

A preamplifier for preamplifying the input biosignal at a preset preamplification rate;

A rectifier for rectifying the preamplified biosignal to generate a rectified biosignal;

Comparing the rectified biosignal with a baseline signal having a predetermined DC voltage level, the peak waveform of the rectified biosignal is recognized, and the amplification ratio of the amplification unit is adjusted so that the magnitude of the peak waveform is within a reference voltage range. Amplification factor adjusting unit to adjust

Biological signal correction apparatus comprising a.
The method of claim 3, wherein

The amplification rate adjusting unit,

By comparing the baseline signal and the rectified biosignal, the peak waveform is recognized within a section of the rectified biosignal in which a peak waveform having a voltage magnitude greater than that of the baseline signal is present. A SAR-ADC unit for converting a magnitude of a peak voltage into a digital bit and applying an amplitude adjustment signal to the first amplifying unit for controlling the output of the first amplifying unit to be within a predetermined range based on the digital bit;

When the magnitude of the final biosignal output from the second amplification unit is out of a predetermined reference voltage range, the final amplification rate may be adjusted by adjusting the first amplification ratio of the first amplification unit or the second amplification ratio of the second amplification unit. Control unit for controlling the signal to be included in the reference voltage range

Biological signal correction apparatus comprising a.
The method of claim 4, wherein

The control unit,

When the magnitude of the final biosignal is out of a predetermined reference voltage range, it is determined whether the output of the first amplifier is included in the predetermined range, and when the output of the first amplifier is not included within the predetermined range, Adjusting the first amplification ratio of the first amplifier by adjusting a value of the digital bit output from the SAR-ADC unit,

And adjusting the second amplification ratio of the second amplifying unit so that the magnitude of the final bio signal is included in the reference voltage range when the output of the first amplifying unit is included in the predetermined range.
The method of claim 4, wherein

The correction device,

A capacitor array for smoothing the bio-signal at an output terminal of the rectifier;

The SAR-ADC unit,

And recognizing the peak value of the peak waveform when the magnitude of the smoothed biosignal is reduced, and then stopping the recognition operation of the peak waveform to minimize power consumption.
The method of claim 2,

The amplitude adjustment unit,

A preamplifier for preamplifying the input biosignal at a preset preamplification rate;

Based on a baseline signal having a predetermined DC voltage level, a peak waveform having a larger voltage magnitude than the baseline signal is detected in a period of each biosignal, and a peak voltage of the detected peak waveform is converted into a plurality of digital bits. With SAR-ADC department to say,

An amplitude adjustment signal for generating a digital bit obtained by subtracting a minimum value from a maximum value among the plurality of digital bits applied from the SAR-ADC unit and controlling the output of the first amplifier to be within a predetermined range based on the digital bit; A peak-to-peak detector applied to the first amplifier,

When the magnitude of the final biosignal output from the second amplifier is out of a predetermined reference voltage range, the first amplification ratio of the first amplifier or the second amplification ratio of the second amplifier is adjusted to adjust the magnitude of the biosignal. A control unit for controlling a to be included in the reference voltage range

Biological signal correction apparatus comprising a.
The method of claim 7, wherein

A reset signal connected to the peak-to-peak detection unit and generating a reset signal set to have a second period corresponding to the first period of the bio-signal to control the operation of the peak-to-peak detection unit, and when the reset signal is applied And a reset generator configured to control the amplitude adjustment signal to be applied to the first amplifier.
The method of claim 8,

The peak-to-peak detection unit,

And a positive edge of the reset signal applied from the reset generator to apply the amplitude adjustment signal to the first amplifier.
A biosignal correction method performed by a biosignal correction apparatus including an amplitude adjusting unit and an amplifying unit,

Receiving the biological signal measured from the biometric information measuring device by the amplitude adjusting unit;

Detecting the magnitude of the biosignal by the amplitude adjustment unit and adjusting the amplification rate of the biosignal in real time according to the magnitude of the biosignal;

Amplifying the biological signal at the amplification unit according to the amplification rate according to the adjustment;

Biological signal correction method comprising a.
The method of claim 10,

The amplification rate includes a first amplification rate and a second amplification rate,

The amplifying step,

Amplifying the biosignal first by the first amplifier in the amplifier according to the first amplification ratio;

Amplifying the biosignal amplified first by the second amplification unit in the second amplifying unit connected in series with the first amplifying unit in accordance with the second amplification ratio;

Biological signal correction method comprising a.
The method of claim 11,

The adjusting step,

Preamplifying the input biosignal by a preset preamplification rate in the amplitude adjusting unit;

Generating a rectified biosignal by rectifying the preamplified biosignal by the amplitude adjusting unit;

The amplitude adjustment unit compares the baseline signal having a predetermined DC voltage level with the rectified biosignal to recognize the peak waveform of the rectified biosignal and controls the peak waveform to have a value within a reference voltage range. step

Biological signal correction method comprising a.
The method of claim 12,

The controlling step,

Comparing the baseline signal with the rectified biosignal by the amplitude adjustment unit and recognizing the peak waveform within a section of the rectified biosignal in which a peak waveform having a voltage magnitude greater than that of the baseline signal exists;

Generating, by the amplitude adjustment unit, an amplitude adjustment signal that converts the magnitude of the peak waveform into digital bits and adjusts the first amplification factor based on the digital bits;

Controlling the amplitude of the peak waveform amplified by the first amplification factor to be within a predetermined range by using the amplitude adjustment signal in the amplitude adjustment unit;

Biological signal correction method comprising a.
The method of claim 13,

The method,

When the amplitude of the final biosignal output through the second amplification ratio is out of a preset reference voltage range, the first amplification ratio of the first amplification unit or the second amplification ratio of the second amplification unit may be adjusted. And controlling the magnitude of a final biosignal to fall within the reference voltage range.
The method of claim 14,

Controlling to fall within the reference voltage range,

Checking whether the output of the first amplifier is included in the predetermined range when the amplitude of the final biosignal is out of the reference voltage range by the amplitude adjusting unit;

If the output of the first amplifier is not within the predetermined range, adjusting the value of the digital bit by the amplitude adjusting unit to adjust a first amplification ratio of the first amplifier;

If the output of the first amplifier is included in the predetermined range, adjusting the second amplification rate so that the amplitude of the final biosignal is included in the reference voltage range by the amplitude adjusting unit;

Biological signal correction method comprising a.
The method of claim 11,

The adjusting step,

Preamplifying the input biosignal by a preset preamplification rate in the amplitude adjusting unit;

The amplitude adjuster detects a peak waveform having a larger voltage magnitude than the baseline signal in a period of each biosignal based on a baseline signal having a predetermined DC voltage level, and multiplies the magnitude of the peak voltage with respect to the detected peak waveform. Converting to digital bits

Generating, by the amplitude adjusting unit, a digital bit obtained by subtracting a minimum value from a maximum value among the plurality of digital bits, and generating an amplitude adjusting signal for adjusting a first amplification ratio of the first amplifier based on the digital bits;

Controlling the amplitude of the peak waveform amplified by the first amplification factor to be within a predetermined range by using the amplitude adjustment signal in the amplitude adjustment unit;

Biological signal correction method comprising a.
The method of claim 16,

The method,

When the amplitude of the final biosignal output through the second amplification ratio is out of a preset reference voltage range, the first amplification ratio of the first amplification unit or the second amplification ratio of the second amplification unit may be adjusted. And controlling the magnitude of a final biosignal to fall within the reference voltage range.
The method of claim 17,

Controlling to fall within the reference voltage range,

Checking whether the output of the first amplifier is included in the predetermined range when the amplitude of the final biosignal is out of the reference voltage range by the amplitude adjusting unit;

If the output of the first amplifier is not within the predetermined range, adjusting the value of the digital bit by the amplitude adjusting unit to adjust a first amplification ratio of the first amplifier;

If the output of the first amplifier is included in the predetermined range, adjusting the second amplification rate so that the amplitude of the final biosignal is included in the reference voltage range by the amplitude adjusting unit;

Biological signal correction method comprising a.
The method of claim 16,

Generating the amplitude adjustment signal,

Generating a reset signal set to have a second period corresponding to the first period of the biosignal by the amplitude adjusting unit;

Generating the amplitude adjustment signal at a time point when the reset signal is applied by the amplitude adjustment unit;

Biological signal correction method comprising a.