WO2018062474A1 - Method for improving drinkability of drinking water to which reduced indigestible dextrin has been added, drinking water to which reduced indigestible dextrin has been added in which drinkability is improved by said method, drinking water for inhibiting fat absorption containing reduced indigestible dextrin, and method for inhibiting dietetic fat absorption - Google Patents

Method for improving drinkability of drinking water to which reduced indigestible dextrin has been added, drinking water to which reduced indigestible dextrin has been added in which drinkability is improved by said method, drinking water for inhibiting fat absorption containing reduced indigestible dextrin, and method for inhibiting dietetic fat absorption Download PDF

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WO2018062474A1
WO2018062474A1 PCT/JP2017/035451 JP2017035451W WO2018062474A1 WO 2018062474 A1 WO2018062474 A1 WO 2018062474A1 JP 2017035451 W JP2017035451 W JP 2017035451W WO 2018062474 A1 WO2018062474 A1 WO 2018062474A1
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Prior art keywords
drinking water
indigestible dextrin
reduced
reduced indigestible
fat absorption
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PCT/JP2017/035451
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French (fr)
Japanese (ja)
Inventor
卓人 鈴木
真由美 中村
金平　努
Original Assignee
ザ コカ・コーラ カンパニー
卓人 鈴木
真由美 中村
金平　努
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Application filed by ザ コカ・コーラ カンパニー, 卓人 鈴木, 真由美 中村, 金平　努 filed Critical ザ コカ・コーラ カンパニー
Priority to CN201780060590.9A priority Critical patent/CN109819647A/en
Priority to KR1020197007046A priority patent/KR20190062393A/en
Publication of WO2018062474A1 publication Critical patent/WO2018062474A1/en

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/68—Treatment of water, waste water, or sewage by addition of specified substances, e.g. trace elements, for ameliorating potable water
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/332—Promoters of weight control and weight loss
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/50—Polysaccharides, gums
    • A23V2250/502—Gums
    • A23V2250/5042—Dextran

Definitions

  • the present invention relates to a method for improving the ease of drinking of drinking water blended with reduced indigestible dextrin, a drinking water blended with reduced indigestible dextrin with improved ease of drinking by the method,
  • the present invention relates to a fat absorption suppressing drinking water and a method for suppressing dietary fat absorption.
  • Indigestible dextrin has been used in various foods in recent years because it has an intestinal regulating effect, a postprandial blood glucose level increase inhibitory effect, a postprandial blood neutral fat level increase suppressive effect, and the like.
  • indigestible dextrins are pale yellow and are difficult to formulate into colorless or pale foods.
  • the reduced indigestible dextrin produced by adding hydrogen to the indigestible dextrin is non-brown and is expected to be used for colorless or light-colored foods.
  • it has been studied to impart functionality by adding a reduced indigestible dextrin to water (see, for example, Patent Document 1).
  • An object of the present invention is to improve the ease of drinking of drinking water containing reduced indigestible dextrin.
  • the present inventors reduced the taste derived from reduced indigestible dextrin by adjusting the hardness of drinking water containing reduced indigestible dextrin, and made it easier to drink. It was found that it can be improved.
  • the present inventors have also found that when drinking water containing reduced indigestible dextrin is ingested, the effect of suppressing the increase in postprandial blood neutral fat level can be obtained. At present, verification of the effect of reducing the postprandial blood neutral fat level by reducing indigestible dextrin has not been conducted.
  • a drinking water comprising a reduced indigestible dextrin having a hardness of 10 to 110.
  • the hardness of the drinking water is adjusted by adding at least one of a magnesium salt and a calcium salt.
  • the hardness of the drinking water is adjusted by blending a plurality of types of water having different hardnesses. 11.
  • a dose of the reduced resistant digestible dextrin in the drinking water is 1 to 16 g per 500 g of drinking water.
  • 12 Drinking water for fat absorption suppression containing reduced indigestible dextrin. 13.
  • 12. The drinking water for inhibiting fat absorption according to 12, wherein the drinking water has a hardness of 10 to 110.
  • 14 The drinking water for fat absorption inhibition according to 13, wherein the weight ratio of calcium to magnesium (Ca / Mg) in the drinking water is 1 to 8.
  • a method for suppressing dietary fat absorption including ingesting 555 mL of the drinking water for fat absorption suppression containing 5 g of reduced indigestible dextrins with a meal once a day.
  • the present invention it is possible to provide drinking water blended with reduced indigestible dextrin with improved ease of drinking. Moreover, according to this invention, the drinking water for fat absorption suppression containing a reduced indigestible dextrin can be provided.
  • FIG. 1 is a graph showing the change over time in blood neutral fat level in Example 2.
  • FIG. FIG. 2 is a diagram showing the area under the blood concentration curve (AUC) of blood triglyceride value in Example 2.
  • FIG. 3 is a graph showing the amount of change in blood triglyceride value ( ⁇ blood triglyceride value) in Example 2.
  • FIG. 4 is a view showing the area (AUC) under the blood concentration curve of the amount of change in blood triglyceride value ( ⁇ blood triglyceride value) in Example 2.
  • the method for improving the ease of drinking of the drinking water blended with the reduced resistant digestible dextrin of the present invention includes adjusting the hardness of the drinking water blended with the reduced resistant digestible dextrin.
  • the taste derived from reduced indigestible dextrin can be reduced, and the ease of drinking is improved. Can do.
  • the “reducible indigestible dextrin” is an indigestible dextrin obtained by enzymatic digestion of roasted dextrin and then hydrogenation to reduce the carbonyl group at the reducing end.
  • Specific examples of such reduced indigestible dextrin include powder type Fiber Sol 2H (trade name) sold by Matsutani Chemical Industry Co., Ltd.
  • “hardness” is a value obtained by converting the concentration of calcium salt and magnesium salt in water (total hardness) into the concentration of calcium carbonate in units of “mg / L”. 1).
  • the water constituting the drinking water is not particularly limited.
  • natural water, tap water, pure water, ultrapure water, RO water (water treated using a reverse osmosis membrane (RO membrane)) Etc. and two or more of these may be mixed as appropriate.
  • water having a specific hardness water may be one kind or a mixture of two or more kinds
  • water having a specific hardness may be any one approved as a food additive.
  • At least one of a calcium salt and a magnesium salt may be added, or a plurality of types of water having different hardnesses may be blended.
  • water may be one kind or a mixture of two or more kinds
  • the weight ratio of calcium to magnesium in the drinking water is preferably 1-8.
  • the dose of the reduced resistant digestible dextrin in the drinking water is not particularly limited and can be appropriately determined. For example, it is 1 to 16 g per 500 g of drinking water.
  • the drinking water is preferably colorless and transparent.
  • colorless and transparent drinking water can be provided by mix
  • the drinking water may be light in color.
  • the drinking water containing the reduced indigestible dextrin of the present invention has a hardness of 10 to 110.
  • the drinking water containing the reduced indigestible dextrin of the present invention has a hardness in a specific range of 10 to 110, so that the taste derived from the reduced indigestible dextrin is reduced and the ease of drinking is improved. is there.
  • the drinking water containing the reduced indigestible dextrin of the present invention preferably has a weight ratio (Ca / Mg) of calcium to magnesium in the drinking water of 1 to 8.
  • the dose of the reduced resistant digestible dextrin in the drinking water is not particularly limited and can be appropriately determined. For example, it is 1 to 16 g per 500 g of drinking water.
  • the drinking water of the present invention is preferably colorless and transparent.
  • colorless and transparent drinking water can be provided by including non-brown-modified reduced resistant digestible dextrin instead of resistant digestible dextrin.
  • the drinking water may be light in color.
  • the other characteristics of the drinking water containing the reduced resistant digestible dextrin of the present invention are as described for the method for improving the ease of drinking drinking water containing the reduced resistant digestible dextrin of the present invention described above. .
  • the drinking water for inhibiting fat absorption according to the present invention is characterized by containing a reduced indigestible dextrin.
  • the drinking water for suppressing fat absorption according to the present invention has an effect of suppressing fat absorption, and can particularly suppress an increase in blood neutral fat level due to dietary fat.
  • the reduced indigestible dextrin By including the reduced indigestible dextrin in the drinking water, there is a problem that the taste derived from the reduced indigestible dextrin is imparted to the drinking water and it becomes difficult to drink, but the reduced indigestible dextrin of the present invention described above is used. Such a problem can be solved by applying a method for improving the ease of drinking the blended drinking water.
  • the drinking water for suppressing fat absorption according to the present invention preferably has a drinking water hardness of 10 to 110 from the viewpoint of improving ease of drinking.
  • the weight ratio of calcium to magnesium (Ca / Mg) in the drinking water is preferably 1-8.
  • the dose of the reduced resistant digestible dextrin in the drinking water is not particularly limited and can be determined as appropriate, and is, for example, 1 to 16 g per 500 g of drinking water.
  • the drinking water of the present invention is preferably colorless and transparent.
  • colorless and transparent drinking water can be provided by including non-brown-modified reduced resistant digestible dextrin instead of resistant digestible dextrin.
  • the drinking water may be light in color.
  • the intake amount and frequency of intake of drinking water for fat absorption suppression of the present invention are not particularly limited, and any amount can be ingested at any frequency.
  • 555 mL of drinking water containing 5 g of reduced indigestible dextrin can be taken with a meal once a day.
  • 555 mL of drinking water containing 5 g of reduced indigestible dextrin can be ingested together with meals for the number of meals per day.
  • the drinking water for inhibiting fat absorption according to the present invention is useful for prevention of postprandial hyperlipidemia and lifestyle-related diseases and arteriosclerotic diseases.
  • the method for suppressing dietary fat absorption of the present invention comprises ingesting 555 mL of fat absorption-suppressing water containing 5 g of reduced resistant digestible dextrin once daily with a meal. To do. According to the method of the present invention, absorption of dietary fat can be suppressed. Moreover, by this, by suppressing fat absorption, it is possible to suppress an increase in blood neutral fat level due to dietary fat.
  • Test example 1 About the drinking water which mix
  • RO membrane reverse osmosis membrane
  • the drinking water (test beverage) formulated with reduced indigestible dextrin has a reduced indigestible dextrin taste compared to drinking water (control beverage) that does not contain reduced indigestible dextrin. It was felt strong and difficult to drink.
  • Example 1 Various drinking waters containing reduced indigestible dextrin were prepared, sensory evaluation was performed on these drinking waters, and the influences of minerals (calcium ions, magnesium ions) and hardness contained in the drinking water were evaluated.
  • the drinking water to be evaluated is the ultrapure water obtained by mixing the natural water shown in Table 2 with the formulation shown in Table 3 and containing natural minerals and the Milli Q water production device (Merck Millipore). Minerals (calcium gluconate (C 12 H 22 CaO 14 ), magnesium sulfate (MgSO 4 )) were added to water to prepare drinking water with a predetermined dose of reduced indigestible dextrin (trade name: Fiber Sol). 2H, manufactured by Matsutani Chemical Industry Co., Ltd.). The dose of reduced resistant digestive dextrin was 2 g / 500 g, 5 g / 500 g, and 15 g / 500 g with respect to 500 g of drinking water. The control drinking water was ultrapure water obtained by a Milli Q water production device (Merck Millipore).
  • the concentration of calcium ions and magnesium ions contained in the drinking water was analyzed by ICP-AES, and the hardness of the drinking water was calculated according to the formula (1) from the concentrations of calcium ions and magnesium ions.
  • Table 4 the sensory evaluation of drinking water was performed by seven specialist panels.
  • Tables 5 to 7 show the results of sensory evaluation for drinking water containing natural minerals
  • Tables 8 to 10 show the results of sensory evaluation for drinking water obtained by adding minerals to ultrapure water.
  • Example 2 The postprandial blood neutral fat elevation inhibitory effect of a reduced-digestible dextrin-containing soft drink was tested according to the following procedure.
  • the subjects were 89 men and women (69 men and 20 women) aged 20 to 65 who had a fasting blood triglyceride level of 120-200 mg / dL, which was slightly higher than the normal high level in the preliminary examination. .
  • the average age of the subjects was 46.2 ⁇ 8.5 years old, BMI was 24.4 ⁇ 2.9, and fasting triglyceride was 147.8 ⁇ 22.0 mg / dL.
  • Test drink As a test beverage, adjusted to contain 5 g of reduced indigestible dextrin (trade name: Fibersol 2H, manufactured by Matsutani Chemical Co., Ltd.) as dietary fiber, and drinking water with an appropriate amount of vitamin C added as an antioxidant Got ready.
  • reduced indigestible dextrin trade name: Fibersol 2H, manufactured by Matsutani Chemical Co., Ltd.
  • a drinking water was prepared that did not contain reduced indigestible dextrin and added vitamin C in the same amount as the test beverage.
  • Loaded food is hamburger (trade name: Yoshokutei hamburger (with Demigrass sauce), Ajinomoto Frozen Foods Co., Ltd.) 180g, French fries (trade name: Cavendish shoe string potato, Miho Japan Co., Ltd.) 50g, bread ( Product name: One butter roll (30 g, manufactured by Tablemark) and one bread (trade name: Neo Butter Roll, manufactured by Fujipan Co., Ltd.).
  • the amount of fat in the loaded food was 40.9 g (720 kcal).
  • Test method The test was performed by a double blind randomized crossover method in which the subjects were randomized into two groups and two test beverages (test beverage and control beverage) were exchanged and ingested. Specifically, the dinner on the day before the test day was completed by 20:00, then fasting was permitted (only water allowed), and the next morning, fasting blood was collected from the cubital vein in the hungry state. The subject was allowed to ingest the test beverage and the loaded food within 1 hour after blood collection, and blood was collected after 2, 3, 4, and 6 hours had elapsed since the start of ingestion. The intake time of the test beverage and the loaded food was generally within 20 minutes. The animals were fasted until the blood collection was completed 6 hours after ingestion, and the sitting position was rested. Then, after a one week rest period, two types of test beverages (test beverage and control beverage) were exchanged, and the test beverage and the loaded food were again taken to collect blood.
  • Y ijkl ⁇ + ⁇ i + ⁇ j + ⁇ k + ⁇ (1) kl + ⁇ (2) ijkl (2) Y ijkl (i, beverage; j, time; k, order; l, subject); ⁇ , overall average; ⁇ , beverage effect; ⁇ , time effect; ⁇ , sequence effect; ⁇ (1) , subject effect (variation between subjects); ⁇ (2) , individual measurement error (variation within subject)
  • test beverage was analyzed by a paired t-test using the control beverage intake as a comparative control.
  • the significance level was 5% by two-sided test, and the IBM SPSS Statistics 24 (Japan IBM Corporation) was used as the statistical analysis software.
  • the test drink ingestion showed a significantly low value compared with the control drink ingestion (Ingestion 2) 4, 6 hours later: P ⁇ 0.05, 3 hours after ingestion: P ⁇ 0.01).
  • the blood neutral fat AUC in FIG. 2 was significantly lower when the test beverage was ingested than when the control beverage was ingested (P ⁇ 0.01).
  • the ⁇ blood triglyceride level in FIG. 3 was significantly lower when the test beverage was ingested 2, 3, 4 and 6 hours after the ingestion of the loaded food than when the control beverage was ingested (ingestion). 2, 3, 4 hours later: P ⁇ 0.01, 6 hours after ingestion: P ⁇ 0.05).
  • About (DELTA) blood neutral fat AUC of FIG. 4 the test drink ingestion showed the significantly low value compared with the control drink ingestion (P ⁇ 0.01).
  • Table 11 shows changes with time of RLP-cholesterol, phospholipid, and ⁇ -lipoprotein.
  • the upper row is the result of the test beverage, and the lower row is the result of the control beverage.
  • PLR-cholesterol was significantly lower (P ⁇ 0.05) 6 hours after ingestion of the loaded food and when the test beverage was ingested than when the control beverage was ingested.
  • Phospholipids showed significantly lower values after ingestion of the loaded food at 2, 4 and 6 hours and at the time of ingestion of the test beverage compared to the intake of the control beverage (2, 4 hours after ingestion: P ⁇ 0. 05, 6 hours after ingestion: P ⁇ 0.01).
  • ⁇ -lipoprotein showed a significantly lower value when the test beverage was ingested 2, 3, 4 and 6 hours after ingestion of the loaded food compared to the intake of the control beverage (ingestion 2, 3, 4 hours).
  • P ⁇ 0.05, 6 hours after ingestion P ⁇ 0.01.
  • the subjects were stratified into a subject having a fasting blood neutral fat value of 150 mg / dL or more and a subject having a fasting blood triglyceride value of less than 150 mg / dL, and a stratified analysis was performed.
  • blood triglyceride levels were 165.1 ⁇ 66.4 mg / mL, respectively, before ingesting the test and control beverages. 170.4 ⁇ 58.1 mg / mL, and no significant difference was observed.
  • the blood triglyceride level was significantly lower at 2, 3, 4, and 6 hours after ingestion of the test beverage than at the time of ingestion of the control beverage (after 2, 3, 4, and 6 hours of ingestion). : P ⁇ 0.05).
  • blood triglyceride levels were 132.1 ⁇ 42.2 mg / mL, respectively, before ingesting the test and control beverages. 134.6 ⁇ 45.3 mg / mL, and no significant difference was observed.
  • the ease of drinking can be improved in the drinking water containing a reduced indigestible dextrin.
  • the drinking water containing the reduced indigestible dextrin which provided the function of fat absorption suppression can be provided.
  • Drinking water can be comfortably incorporated and consumed in normal eating habits, and by continuously and regularly ingesting the drinking water for inhibiting fat absorption of the present invention, postprandial hyperlipidemia and lifestyle-related diseases It is thought that it is also effective for prevention.

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Abstract

Drinking water containing reduced indigestible dextrin, wherein the drinking water has a hardness of 10-110.

Description

還元難消化性デキストリンを配合した飲料水の飲みやすさを向上させる方法、当該方法により飲みやすさを向上させた還元難消化性デキストリンを配合した飲料水、還元難消化性デキストリンを含む脂肪吸収抑制用の飲料水、及び、食事性の脂肪吸収を抑制するための方法Method for improving the ease of drinking of drinking water containing reduced indigestible dextrin, drinking water containing reduced indigestible dextrin with improved ease of drinking by the method, suppression of fat absorption including reduced indigestible dextrin Drinking water and method for inhibiting dietary fat absorption
　本発明は、還元難消化性デキストリンを配合した飲料水の飲みやすさを向上させる方法、当該方法により飲みやすさを向上させた還元難消化性デキストリンを配合した飲料水、還元難消化性デキストリンを含む脂肪吸収抑制用の飲料水、及び、食事性の脂肪吸収を抑制するための方法に関する。 The present invention relates to a method for improving the ease of drinking of drinking water blended with reduced indigestible dextrin, a drinking water blended with reduced indigestible dextrin with improved ease of drinking by the method, The present invention relates to a fat absorption suppressing drinking water and a method for suppressing dietary fat absorption.
　難消化性デキストリンは、整腸作用、食後血糖値上昇抑制作用、食後血中中性脂肪値上昇抑制効果等を有していることから、近年、種々の食品に配合され、利用されている。しかし、難消化性デキストリンは淡黄色であり、無色や淡色の食品への配合は難しいという側面がある。
　一方、難消化性デキストリンに水素を添加することにより生成される還元難消化性デキストリンは、非褐変性であり、無色や淡色の食品に対する利用が期待される。例として、水に還元難消化性デキストリンを添加して機能性を付与することが検討されている（例えば、特許文献１参照）。 Indigestible dextrin has been used in various foods in recent years because it has an intestinal regulating effect, a postprandial blood glucose level increase inhibitory effect, a postprandial blood neutral fat level increase suppressive effect, and the like. However, indigestible dextrins are pale yellow and are difficult to formulate into colorless or pale foods.
On the other hand, the reduced indigestible dextrin produced by adding hydrogen to the indigestible dextrin is non-brown and is expected to be used for colorless or light-colored foods. As an example, it has been studied to impart functionality by adding a reduced indigestible dextrin to water (see, for example, Patent Document 1).
　しかし、還元難消化性デキストリンを飲料水に配合した場合、還元難消化性デキストリンに由来する味が飲料水に付与されてしまい、飲みにくくなってしまうという問題がある。 However, when a reduced resistant digestible dextrin is blended in drinking water, the taste derived from the reduced resistant digestible dextrin is imparted to the drinking water, which makes it difficult to drink.
特開２００５－２８７４５４号公報JP 2005-287454 A
　本発明の目的は、還元難消化性デキストリンを配合した飲料水の飲みやすさを向上させることにある。 An object of the present invention is to improve the ease of drinking of drinking water containing reduced indigestible dextrin.
　上記課題に鑑み研究した結果、本発明者らは、還元難消化性デキストリンを配合した飲料水について、硬度を調節することにより、還元難消化性デキストリンに由来する味を低減し、飲みやすさを向上させることができることを見出した。 As a result of studying in view of the above problems, the present inventors reduced the taste derived from reduced indigestible dextrin by adjusting the hardness of drinking water containing reduced indigestible dextrin, and made it easier to drink. It was found that it can be improved.
　さらに、本発明者らは、還元難消化性デキストリンを配合した飲料水を摂取した場合に、食後血中中性脂肪値の上昇抑制効果が得られることも見出した。還元難消化性デキストリンによる食後血中中性脂肪値上昇抑制効果の検証は、現在のところ行われていない。 Furthermore, the present inventors have also found that when drinking water containing reduced indigestible dextrin is ingested, the effect of suppressing the increase in postprandial blood neutral fat level can be obtained. At present, verification of the effect of reducing the postprandial blood neutral fat level by reducing indigestible dextrin has not been conducted.
　本発明によれば、以下の飲みやすさが向上された、還元難消化性デキストリンを配合した飲料水等を提供できる。
１．還元難消化性デキストリンを含む飲料水であって、硬度が１０～１１０である前記飲料水。
２．前記飲料水中のマグネシウムに対するカルシウムの重量比（Ｃａ／Ｍｇ）が１～８である１に記載の飲料水。
３．前記飲料水中の還元難消化性デキストリンの用量が飲料水５００ｇあたり１～１６ｇである１又は２に記載の飲料水。
４．無色透明である、１～３のいずれかに記載の飲料水。
５．天然水を含む、１～４のいずれかに記載の飲料水。
６．還元難消化性デキストリンを配合した飲料水の飲みやすさを向上させる方法であって、
　前記飲料水の硬度を調節することを含む前記方法。
７．前記飲料水の硬度を１０～１１０に調節する、６に記載の方法。
８．前記飲料水中のマグネシウムに対するカルシウムの重量比（Ｃａ／Ｍｇ）が１～８である、７に記載の方法。
９．マグネシウム塩及びカルシウム塩の少なくとも一方を添加することにより、前記飲料水の硬度を調節する、６～８のいずれかに記載の方法。
１０．硬度の異なる複数種の水を配合することにより、前記飲料水の硬度を調節する、６～９のいずれかに記載の方法。
１１．前記飲料水中の還元難消化性デキストリンの用量が飲料水５００ｇあたり１～１６ｇである、６～１０のいずれかに記載の方法。
１２．還元難消化性デキストリンを含む脂肪吸収抑制用の飲料水。
１３．前記飲料水の硬度が１０～１１０である、１２に記載の脂肪吸収抑制用の飲料水。
１４．前記飲料水中のマグネシウムに対するカルシウムの重量比（Ｃａ／Ｍｇ）が１～８である、１３に記載の脂肪吸収抑制用の飲料水。
１５．前記飲料水中の還元難消化性デキストリンの用量が飲料水５００ｇあたり１～１６ｇである、１２～１４のいずれかに記載の脂肪吸収抑制用の飲料水。
１６．無色透明である、１２～１５のいずれかに記載の飲料水。
１７．食事性の脂肪吸収を抑制するための方法であって、
　還元難消化性デキストリン５ｇを含む脂肪吸収抑制用の飲料水５５５ｍＬを食事と一緒に１日１回摂取することを含む前記方法。 ADVANTAGE OF THE INVENTION According to this invention, the drinking water etc. which mix | blended the reduction indigestible dextrin improved the following ease of drinking can be provided.
1. A drinking water comprising a reduced indigestible dextrin having a hardness of 10 to 110.
2. 2. The drinking water according to 1, wherein the weight ratio of calcium to magnesium (Ca / Mg) in the drinking water is 1-8.
3. 3. The drinking water according to 1 or 2, wherein the reduced resistant digestible dextrin in the drinking water is 1 to 16 g per 500 g of drinking water.
4). The drinking water according to any one of 1 to 3, which is colorless and transparent.
5). 5. Drinking water according to any one of 1 to 4, comprising natural water.
6). A method of improving the ease of drinking drinking water containing reduced indigestible dextrin,
Adjusting the hardness of the drinking water.
7). The method according to 6, wherein the hardness of the drinking water is adjusted to 10 to 110.
8). The method according to 7, wherein the weight ratio of calcium to magnesium (Ca / Mg) in the drinking water is 1-8.
9. The method according to any one of 6 to 8, wherein the hardness of the drinking water is adjusted by adding at least one of a magnesium salt and a calcium salt.
10. The method according to any one of 6 to 9, wherein the hardness of the drinking water is adjusted by blending a plurality of types of water having different hardnesses.
11. The method according to any one of 6 to 10, wherein a dose of the reduced resistant digestible dextrin in the drinking water is 1 to 16 g per 500 g of drinking water.
12 Drinking water for fat absorption suppression containing reduced indigestible dextrin.
13. 12. The drinking water for inhibiting fat absorption according to 12, wherein the drinking water has a hardness of 10 to 110.
14 The drinking water for fat absorption inhibition according to 13, wherein the weight ratio of calcium to magnesium (Ca / Mg) in the drinking water is 1 to 8.
15. The drinking water for suppressing fat absorption according to any one of 12 to 14, wherein a dose of the reduced resistant digestible dextrin in the drinking water is 1 to 16 g per 500 g of drinking water.
16. The drinking water according to any one of 12 to 15, which is colorless and transparent.
17. A method for suppressing dietary fat absorption,
The said method including ingesting 555 mL of the drinking water for fat absorption suppression containing 5 g of reduced indigestible dextrins with a meal once a day.
　本発明によれば、飲みやすさが向上された、還元難消化性デキストリンを配合した飲料水を提供することができる。また、本発明によれば、還元難消化性デキストリンを含む脂肪吸収抑制用の飲料水を提供できる。 According to the present invention, it is possible to provide drinking water blended with reduced indigestible dextrin with improved ease of drinking. Moreover, according to this invention, the drinking water for fat absorption suppression containing a reduced indigestible dextrin can be provided.
図１は、実施例２における血中中性脂肪値の経時変化を示す図である。FIG. 1 is a graph showing the change over time in blood neutral fat level in Example 2. FIG. 図２は、実施例２における血中中性脂肪値の血中濃度曲線下面積（ＡＵＣ）を示す図である。FIG. 2 is a diagram showing the area under the blood concentration curve (AUC) of blood triglyceride value in Example 2. 図３は、実施例２における血中中性脂肪値の変化量（Δ血中中性脂肪値）を示す図である。FIG. 3 is a graph showing the amount of change in blood triglyceride value (Δblood triglyceride value) in Example 2. 図４は、実施例２における血中中性脂肪値の変化量（Δ血中中性脂肪値）の血中濃度曲線下面積（ＡＵＣ）を示す図である。FIG. 4 is a view showing the area (AUC) under the blood concentration curve of the amount of change in blood triglyceride value (Δblood triglyceride value) in Example 2.
［還元難消化性デキストリンを配合した飲料水の飲みやすさを向上させるための方法］
　本発明の還元難消化性デキストリンを配合した飲料水の飲みやすさを向上させるための方法は、還元難消化性デキストリンを配合した飲料水の硬度を調節することを含むことを特徴とする。 [Method for improving ease of drinking drinking water containing reduced indigestible dextrin]
The method for improving the ease of drinking of the drinking water blended with the reduced resistant digestible dextrin of the present invention includes adjusting the hardness of the drinking water blended with the reduced resistant digestible dextrin.
　本発明によれば、還元難消化性デキストリンを配合した飲料水において、還元難消化性デキストリンに由来する味（後述する試験例１を参照）を低減することができ、飲みやすさを向上させることができる。 According to the present invention, in drinking water containing reduced indigestible dextrin, the taste derived from reduced indigestible dextrin (see Test Example 1 described later) can be reduced, and the ease of drinking is improved. Can do.
　本発明において「還元難消化性デキストリン」とは、焙焼デキストリンを酵素消化し、次いで水素添加して、還元末端のカルボニル基を還元して得られる難消化性デキストリンである。このような還元難消化性デキストリンとして、具体的には、松谷化学工業株式会社から販売されている粉末タイプのファイバーソル２Ｈ（商品名）等がある。 In the present invention, the “reducible indigestible dextrin” is an indigestible dextrin obtained by enzymatic digestion of roasted dextrin and then hydrogenation to reduce the carbonyl group at the reducing end. Specific examples of such reduced indigestible dextrin include powder type Fiber Sol 2H (trade name) sold by Matsutani Chemical Industry Co., Ltd.
　本発明において「硬度」とは、水中のカルシウム塩とマグネシウム塩の濃度（総硬度）を炭酸カルシウムの濃度に換算した値を「ｍｇ／Ｌ」の単位で表したものであり、次の式（１）により求められる。 In the present invention, “hardness” is a value obtained by converting the concentration of calcium salt and magnesium salt in water (total hardness) into the concentration of calcium carbonate in units of “mg / L”. 1).
［ＣａＣＯ３］（ｍｇ／Ｌ）＝［カルシウムイオン］（ｍｇ／Ｌ）×２．５＋［マグネシウムイオン］（ｍｇ／Ｌ）×４．１　　　　（１） [CaCO 3 ] (mg / L) = [Calcium ion] (mg / L) × 2.5 + [Magnesium ion] (mg / L) × 4.1 (1)
　本発明の方法においては、飲料水の硬度を、１０～１１０に調節することが好ましい。 In the method of the present invention, it is preferable to adjust the hardness of drinking water to 10 to 110.
　本発明の方法において、飲料水を構成する水は特に限定されず、例えば、天然水、水道水、純水、超純水、ＲＯ水（逆浸透膜（ＲＯ膜）を用いて処理した水）等を使用でき、また、これらのうち二種以上を適宜混合してもよい。
　本発明において、硬度を調節するためには、特定の硬度を有する水（水は一種でもよく、二種以上を混合したものであってもよい）に、食品添加物として認可されている任意のカルシウム塩及びマグネシウム塩の少なくとも一方を添加してもよく、また、硬度の異なる複数種の水を配合してもよい。
　尚、本発明において、飲料水を構成する水（水は一種でもよく、二種以上を混合したものであってもよい）の硬度が、既に１０～１１０の範囲内である場合には、改めて硬度を調節する必要はない。 In the method of the present invention, the water constituting the drinking water is not particularly limited. For example, natural water, tap water, pure water, ultrapure water, RO water (water treated using a reverse osmosis membrane (RO membrane)) Etc., and two or more of these may be mixed as appropriate.
In the present invention, in order to adjust the hardness, water having a specific hardness (water may be one kind or a mixture of two or more kinds) may be any one approved as a food additive. At least one of a calcium salt and a magnesium salt may be added, or a plurality of types of water having different hardnesses may be blended.
In the present invention, when the hardness of the water constituting the drinking water (water may be one kind or a mixture of two or more kinds) is already within the range of 10 to 110, it is anew. There is no need to adjust the hardness.
　また、本発明の方法において、飲料水中のマグネシウムに対するカルシウムの重量比（Ｃａ／Ｍｇ）は１～８であることが好ましい。 In the method of the present invention, the weight ratio of calcium to magnesium in the drinking water (Ca / Mg) is preferably 1-8.
　飲料水中の還元難消化性デキストリンの用量は、特に限定されず適宜決定することができるが、例えば、飲料水５００ｇあたり、１～１６ｇ等である。 The dose of the reduced resistant digestible dextrin in the drinking water is not particularly limited and can be appropriately determined. For example, it is 1 to 16 g per 500 g of drinking water.
　飲料水は、好ましくは、無色透明である。本発明においては、難消化性デキストリンではなく、非褐変性の還元難消化性デキストリンを配合することにより、無色透明の飲料水を提供することができる。
　また、飲料水は、淡色であってもよい。 The drinking water is preferably colorless and transparent. In this invention, colorless and transparent drinking water can be provided by mix | blending not a non-digestible dextrin but a non-brown-modified reduced resistant digestible dextrin.
The drinking water may be light in color.
［還元難消化性デキストリンを含む飲料水］
　本発明の還元難消化性デキストリンを含む飲料水は、硬度が１０～１１０であることを特徴とする。
　本発明の還元難消化性デキストリンを含む飲料水は、硬度が１０～１１０という特定の範囲であることにより、還元難消化性デキストリンに由来する味が低減され、飲みやすさが向上されたものである。 [Drinking water containing reduced indigestible dextrin]
The drinking water containing the reduced indigestible dextrin of the present invention has a hardness of 10 to 110.
The drinking water containing the reduced indigestible dextrin of the present invention has a hardness in a specific range of 10 to 110, so that the taste derived from the reduced indigestible dextrin is reduced and the ease of drinking is improved. is there.
　また、本発明の還元難消化性デキストリンを含む飲料水は、飲料水中のマグネシウムに対するカルシウムの重量比（Ｃａ／Ｍｇ）が１～８であることが好ましい。 Further, the drinking water containing the reduced indigestible dextrin of the present invention preferably has a weight ratio (Ca / Mg) of calcium to magnesium in the drinking water of 1 to 8.
　飲料水中の還元難消化性デキストリンの用量は、特に限定されず適宜決定することができるが、例えば、飲料水５００ｇあたり、１～１６ｇ等である。 The dose of the reduced resistant digestible dextrin in the drinking water is not particularly limited and can be appropriately determined. For example, it is 1 to 16 g per 500 g of drinking water.
　本発明の飲料水は、好ましくは、無色透明である。本発明においては、難消化性デキストリンではなく、非褐変性の還元難消化性デキストリンを含むことにより、無色透明の飲料水を提供することができる。
　また、飲料水は、淡色であってもよい。 The drinking water of the present invention is preferably colorless and transparent. In the present invention, colorless and transparent drinking water can be provided by including non-brown-modified reduced resistant digestible dextrin instead of resistant digestible dextrin.
The drinking water may be light in color.
　本発明の還元難消化性デキストリンを含む飲料水の他の特徴は、上記説明した本発明の還元難消化性デキストリンを配合した飲料水の飲みやすさを向上させるための方法について説明したとおりである。 The other characteristics of the drinking water containing the reduced resistant digestible dextrin of the present invention are as described for the method for improving the ease of drinking drinking water containing the reduced resistant digestible dextrin of the present invention described above. .
［還元難消化性デキストリンを含む脂肪吸収抑制用の飲料水］
　本発明の脂肪吸収抑制用の飲料水は、還元難消化性デキストリンを含むことを特徴とする。
　本発明の脂肪吸収抑制用の飲料水は、脂肪の吸収を抑制する効果を有し、特に食事性の脂肪による血中中性脂肪値の上昇を抑制することができる。 [Drinking water for reducing fat absorption containing reduced indigestible dextrin]
The drinking water for inhibiting fat absorption according to the present invention is characterized by containing a reduced indigestible dextrin.
The drinking water for suppressing fat absorption according to the present invention has an effect of suppressing fat absorption, and can particularly suppress an increase in blood neutral fat level due to dietary fat.
　還元難消化性デキストリンを飲料水に含むことにより、飲料水に還元難消化性デキストリンに由来する味が付与され、飲みにくくなるという問題があるが、上記説明した本発明の還元難消化性デキストリンを配合した飲料水の飲みやすさを向上させるための方法を適用すれば、かかる問題を解消することができる。 By including the reduced indigestible dextrin in the drinking water, there is a problem that the taste derived from the reduced indigestible dextrin is imparted to the drinking water and it becomes difficult to drink, but the reduced indigestible dextrin of the present invention described above is used. Such a problem can be solved by applying a method for improving the ease of drinking the blended drinking water.
　本発明の脂肪吸収抑制用の飲料水は、飲みやすさを向上する観点から、飲料水の硬度が１０～１１０であることが好ましい。また、飲料水中のマグネシウムに対するカルシウムの重量比（Ｃａ／Ｍｇ）が１～８であることが好ましい。 The drinking water for suppressing fat absorption according to the present invention preferably has a drinking water hardness of 10 to 110 from the viewpoint of improving ease of drinking. The weight ratio of calcium to magnesium (Ca / Mg) in the drinking water is preferably 1-8.
　本発明の脂肪吸収抑制用の飲料水において、飲料水中の還元難消化性デキストリンの用量は、特に限定されず適宜決定することができるが、例えば、飲料水５００ｇあたり、１～１６ｇ等である。 In the drinking water for suppressing fat absorption of the present invention, the dose of the reduced resistant digestible dextrin in the drinking water is not particularly limited and can be determined as appropriate, and is, for example, 1 to 16 g per 500 g of drinking water.
　本発明の飲料水は、好ましくは、無色透明である。本発明においては、難消化性デキストリンではなく、非褐変性の還元難消化性デキストリンを含むことにより、無色透明の飲料水を提供することができる。
　また、飲料水は、淡色であってもよい。 The drinking water of the present invention is preferably colorless and transparent. In the present invention, colorless and transparent drinking water can be provided by including non-brown-modified reduced resistant digestible dextrin instead of resistant digestible dextrin.
The drinking water may be light in color.
　本発明の脂肪吸収抑制用の飲料水の摂取量及び摂取の頻度は、特に限定されず、任意の量を任意の頻度で摂取することができる。例えば、還元難消化性デキストリン５ｇを含む飲料水５５５ｍＬを食事と一緒に１日１回摂取することができる。また、例えば、還元難消化性デキストリン５ｇを含む飲料水５５５ｍＬを食事と一緒に１日の食事の回数分摂取することができる。 The intake amount and frequency of intake of drinking water for fat absorption suppression of the present invention are not particularly limited, and any amount can be ingested at any frequency. For example, 555 mL of drinking water containing 5 g of reduced indigestible dextrin can be taken with a meal once a day. In addition, for example, 555 mL of drinking water containing 5 g of reduced indigestible dextrin can be ingested together with meals for the number of meals per day.
　また、本発明の脂肪吸収抑制用の飲料水は、食後高脂血症や生活習慣病の予防、動脈硬化性疾患の予防にも有用であると考えられる。 In addition, it is considered that the drinking water for inhibiting fat absorption according to the present invention is useful for prevention of postprandial hyperlipidemia and lifestyle-related diseases and arteriosclerotic diseases.
［食事性の脂肪吸収を抑制するための方法］
　本発明の食事性の脂肪吸収を抑制するための方法は、還元難消化性デキストリン５ｇを含む脂肪吸収抑制用の飲料水５５５ｍＬを食事と一緒に１日１回摂取することを含むことを特徴とする。
　本発明の方法によれば、食事性の脂肪の吸収を抑制することができる。また、これにより、脂肪の吸収を抑制することにより、食事性の脂肪による血中中性脂肪値の上昇を抑制することができる。 [Method for suppressing dietary fat absorption]
The method for suppressing dietary fat absorption of the present invention comprises ingesting 555 mL of fat absorption-suppressing water containing 5 g of reduced resistant digestible dextrin once daily with a meal. To do.
According to the method of the present invention, absorption of dietary fat can be suppressed. Moreover, by this, by suppressing fat absorption, it is possible to suppress an increase in blood neutral fat level due to dietary fat.
　以下、実施例を示して本発明をさらに具体的に説明するが、本発明の範囲はこれら実施例の記載に何ら限定されるものではない。 Hereinafter, the present invention will be described more specifically with reference to examples. However, the scope of the present invention is not limited to the description of these examples.
試験例１
　還元難消化性デキストリンを水に配合した飲料水について、飲みやすさを官能評価した。
　具体的には、被験飲料として、還元難消化性デキストリン（商品名：ファイバーソル２Ｈ、松谷化学工業株式会社製）をそれぞれ２ｇ、５ｇ、１０ｇ、１５ｇ含有するように調整した飲料水５００ｇと、対照飲料として、還元難消化性デキストリンを配合しない飲料水について、専門パネル７人により、後述する表４のスケールにしたがい、還元難消化性デキストリンの味の強さと、飲みやすさを評価した。被験飲料及び対照飲料を構成する水は、逆浸透膜（ＲＯ膜）を用いて処理したＲＯ水を用いた。 Test example 1
About the drinking water which mix | blended the reduced indigestible dextrin with water, the ease of drinking was sensory-evaluated.
Specifically, as a test beverage, 500 g of drinking water adjusted to contain 2 g, 5 g, 10 g, and 15 g of reduced indigestible dextrin (trade name: Fiber Sol 2H, manufactured by Matsutani Chemical Industry Co., Ltd.) and a control, respectively. About the drinking water which does not mix | blend a reduced indigestible dextrin as a drink, according to the scale of Table 4 mentioned later by 7 expert panels, the strength of the taste of a reduced indigestible dextrin and ease of drinking were evaluated. As the water constituting the test beverage and the control beverage, RO water treated with a reverse osmosis membrane (RO membrane) was used.
　また、被験飲料及び対照飲料中に含まれるカルシウムイオン及びマグネシウムイオンの濃度をＩＣＰ－ＡＥＳにより分析し、カルシウムイオン及びマグネシウムイオンの濃度から式（１）にしたがい硬度を算出した。結果を表１に示す。 Further, the concentrations of calcium ions and magnesium ions contained in the test beverage and the control beverage were analyzed by ICP-AES, and the hardness was calculated according to the formula (1) from the concentrations of calcium ions and magnesium ions. The results are shown in Table 1.
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
　表１に示すように、還元難消化性デキストリンを配合した飲料水（被験飲料）は、還元難消化性デキストリンを含まない飲料水（対照飲料）と比較して、還元難消化性デキストリンの味が強く感じられ、飲みにくいと評価された。 As shown in Table 1, the drinking water (test beverage) formulated with reduced indigestible dextrin has a reduced indigestible dextrin taste compared to drinking water (control beverage) that does not contain reduced indigestible dextrin. It was felt strong and difficult to drink.
実施例１
　還元難消化性デキストリンを配合した種々の飲料水を調製し、これらの飲料水について官能評価を実施し、飲料水中に含まれるミネラル（カルシウムイオン、マグネシウムイオン）及び硬度による影響を評価した。 Example 1
Various drinking waters containing reduced indigestible dextrin were prepared, sensory evaluation was performed on these drinking waters, and the influences of minerals (calcium ions, magnesium ions) and hardness contained in the drinking water were evaluated.
　評価対象の飲料水は、表２に示す天然水を表３に示す配合で混合した、天然由来のミネラルを含む飲料水と、ミリＱ水製造装置（メルクミリポア社製）により得られた超純水にミネラル（グルコン酸カルシウム（Ｃ１２Ｈ２２ＣａＯ１４）、硫酸マグネシウム（ＭｇＳＯ４））を添加して調製した飲料水に、それぞれ、既定の用量の還元難消化性デキストリン（商品名：ファイバーソル２Ｈ、松谷化学工業株式会社製）を配合することにより調製した。還元難消化性デキストリンの用量は、飲料水５００ｇに対して、２ｇ／５００ｇ、５ｇ／５００ｇ、１５ｇ／５００ｇとした。
　対照の飲料水は、ミリＱ水製造装置（メルクミリポア社製）により得られた超純水とした。 The drinking water to be evaluated is the ultrapure water obtained by mixing the natural water shown in Table 2 with the formulation shown in Table 3 and containing natural minerals and the Milli Q water production device (Merck Millipore). Minerals (calcium gluconate (C 12 H 22 CaO 14 ), magnesium sulfate (MgSO 4 )) were added to water to prepare drinking water with a predetermined dose of reduced indigestible dextrin (trade name: Fiber Sol). 2H, manufactured by Matsutani Chemical Industry Co., Ltd.). The dose of reduced resistant digestive dextrin was 2 g / 500 g, 5 g / 500 g, and 15 g / 500 g with respect to 500 g of drinking water.
The control drinking water was ultrapure water obtained by a Milli Q water production device (Merck Millipore).
　飲料水中に含まれるカルシウムイオン及びマグネシウムイオンの濃度をＩＣＰ－ＡＥＳにより分析し、カルシウムイオン及びマグネシウムイオンの濃度から式（１）にしたがい飲料水の硬度を算出した。 The concentration of calcium ions and magnesium ions contained in the drinking water was analyzed by ICP-AES, and the hardness of the drinking water was calculated according to the formula (1) from the concentrations of calcium ions and magnesium ions.
　また、表４に示すスケールにしたがって、専門パネル７人により飲料水の官能評価を実施した。天然由来のミネラルを含む飲料水についての官能評価の結果を表５～表７に、超純水にミネラルを添加した飲料水についての官能評価の結果を表８～表１０に示す。 In addition, according to the scale shown in Table 4, the sensory evaluation of drinking water was performed by seven specialist panels. Tables 5 to 7 show the results of sensory evaluation for drinking water containing natural minerals, and Tables 8 to 10 show the results of sensory evaluation for drinking water obtained by adding minerals to ultrapure water.
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000003
　表３から、対照である超純水と、還元難消化性デキストリン１％水溶液は、ミネラルを含まないことを確認した。 From Table 3, it was confirmed that the control ultrapure water and the reduced indigestible dextrin 1% aqueous solution did not contain minerals.
Figure JPOXMLDOC01-appb-T000004
Figure JPOXMLDOC01-appb-T000004
Figure JPOXMLDOC01-appb-T000005
Figure JPOXMLDOC01-appb-T000005
Figure JPOXMLDOC01-appb-T000006
Figure JPOXMLDOC01-appb-T000006
Figure JPOXMLDOC01-appb-T000007
Figure JPOXMLDOC01-appb-T000007
Figure JPOXMLDOC01-appb-T000008
Figure JPOXMLDOC01-appb-T000008
Figure JPOXMLDOC01-appb-T000009
Figure JPOXMLDOC01-appb-T000009
Figure JPOXMLDOC01-appb-T000010
Figure JPOXMLDOC01-appb-T000010
　表４～表６の結果から、硬度が１４．４～１０６．３の場合に、対照と比較して、還元難消化性デキストリンの味を低減して、飲みやすさを向上することができた。
　表８～表１０の結果から、硬度が１４．４～１０６．３の場合に、対照と比較して、還元難消化性デキストリンの味を低減して、飲みやすさを向上することができた。
　また、マグネシウムに対するカルシウムの重量比（Ｃａ／Ｍｇ）が１．４～７．４の場合に、還元難消化性デキストリンの味を低減して、飲みやすさを向上することができた。 From the results of Tables 4 to 6, when the hardness was 14.4 to 106.3, the taste of the reduced indigestible dextrin was reduced and the ease of drinking was improved compared to the control. .
From the results of Tables 8 to 10, when the hardness was 14.4 to 106.3, it was possible to reduce the taste of the reduced indigestible dextrin and improve the ease of drinking compared to the control. .
In addition, when the weight ratio of calcium to magnesium (Ca / Mg) was 1.4 to 7.4, the taste of the reduced indigestible dextrin was reduced and the ease of drinking could be improved.
実施例２
　還元難消化性デキストリン配合清涼飲料水の食後血中中性脂肪の上昇抑制効果を、以下の手順にしたがい試験した。 Example 2
The postprandial blood neutral fat elevation inhibitory effect of a reduced-digestible dextrin-containing soft drink was tested according to the following procedure.
（被験者）
　事前検査において空腹時血中中性脂肪値が正常高値域からやや高めの１２０～２００ｍｇ／ｄＬを示した２０歳以上６５歳未満の男女８９名（男性６９名、女性２０名）を被験者とした。被験者の平均年齢は４６．２±８．５歳、ＢＭＩは２４．４±２．９、空腹時中性脂肪は１４７．８±２２．０ｍｇ／ｄＬであった。 (subject)
The subjects were 89 men and women (69 men and 20 women) aged 20 to 65 who had a fasting blood triglyceride level of 120-200 mg / dL, which was slightly higher than the normal high level in the preliminary examination. . The average age of the subjects was 46.2 ± 8.5 years old, BMI was 24.4 ± 2.9, and fasting triglyceride was 147.8 ± 22.0 mg / dL.
（試験飲料）
　被験飲料として、還元難消化性デキストリン（商品名：ファイバーソル２Ｈ、松谷化学工業株式会社製）を食物繊維として５ｇ含有するように調整し、酸化防止剤として適量のビタミンＣを添加した飲料水を準備した。対照飲料として、還元難消化性デキストリンを配合せず、被験飲料と同量のビタミンＣを添加した飲料水を準備した。これらを５５５ｍＬ容量のペットボトル飲料とし、外観、風味による区別がつかないことを確認した。 (Test drink)
As a test beverage, adjusted to contain 5 g of reduced indigestible dextrin (trade name: Fibersol 2H, manufactured by Matsutani Chemical Co., Ltd.) as dietary fiber, and drinking water with an appropriate amount of vitamin C added as an antioxidant Got ready. As a control beverage, a drinking water was prepared that did not contain reduced indigestible dextrin and added vitamin C in the same amount as the test beverage. These were made into 555 mL capacity | capacitance PET bottle drinks, and it confirmed that the distinction by the external appearance and flavor was not made.
（負荷食品）
　負荷食品は、ハンバーグ（商品名：洋食亭のハンバーグ（デミグラスソース入り）、味の素冷凍食品株式会社製）１８０ｇ、フライドポテト（商品名：キャベンディッシュ　シューストリングポテト、ミホウジャパン株式会社製）５０ｇ、パン（商品名：バターロール（３０ｇ）、テーブルマーク製）１個、パン（商品名：ネオバターロール、フジパン株式会社製）１個とした。負荷食品の脂肪量は４０．９ｇ（７２０ｋｃａｌ）とした。 (Load food)
Loaded food is hamburger (trade name: Yoshokutei hamburger (with Demigrass sauce), Ajinomoto Frozen Foods Co., Ltd.) 180g, French fries (trade name: Cavendish shoe string potato, Miho Japan Co., Ltd.) 50g, bread ( Product name: One butter roll (30 g, manufactured by Tablemark) and one bread (trade name: Neo Butter Roll, manufactured by Fujipan Co., Ltd.). The amount of fat in the loaded food was 40.9 g (720 kcal).
（試験方法）
　試験は、被験者を２群にランダム化し、２種類の試験飲料（被験飲料と対照飲料）を入れ替えて摂取する、二重盲検ランダム化クロスオーバー法により実施した。
　具体的には、試験日前日の夕食を２０時までに済ませ、その後は絶食（水のみ許可）とし、翌朝、空腹状態にて肘静脈部より空腹時の採血を行った。被験者には、採血の後１時間以内に試験飲料及び負荷食品を摂取させ、摂取開始から２、３、４、６時間経過後にそれぞれ採血を行った。試験飲料及び負荷食品の摂取時間は概ね２０分以内とした。摂取６時間後の採血が終了するまでは絶食とし、坐位安静とした。次いで、１週間の休止期間を設けた後、２種類の試験飲料（被験飲料と対照飲料）を入れ替えて、再び試験飲料及び負荷食品を摂取させて採血を行った。 (Test method)
The test was performed by a double blind randomized crossover method in which the subjects were randomized into two groups and two test beverages (test beverage and control beverage) were exchanged and ingested.
Specifically, the dinner on the day before the test day was completed by 20:00, then fasting was permitted (only water allowed), and the next morning, fasting blood was collected from the cubital vein in the hungry state. The subject was allowed to ingest the test beverage and the loaded food within 1 hour after blood collection, and blood was collected after 2, 3, 4, and 6 hours had elapsed since the start of ingestion. The intake time of the test beverage and the loaded food was generally within 20 minutes. The animals were fasted until the blood collection was completed 6 hours after ingestion, and the sitting position was rested. Then, after a one week rest period, two types of test beverages (test beverage and control beverage) were exchanged, and the test beverage and the loaded food were again taken to collect blood.
（測定・評価項目）
　採血した血液中の中性脂肪、ＲＬＰ－コレステロール、リン脂質、β－リポ蛋白について、株式会社ＬＳＩメディエンス中央総合ラボラトリーに委託して測定した。主要評価項目は、血中中性脂肪値の経時変化及び血中濃度曲線下面積（area　under　the　curve：ＡＵＣ）とし、平均値±標準誤差（ＳＥ）で示し、測定値と変化量を評価した。ＲＬＰ－コレステロール、リン脂質、β－リポ蛋白は副次的評価項目とした。 (Measurement and evaluation items)
Neutral fat, RLP-cholesterol, phospholipid, and β-lipoprotein in the collected blood were measured by outsourcing to LSI Medians Central Research Laboratory. The primary endpoint was the time-dependent change in blood triglyceride value and the area under the curve (AUC), which was expressed as mean ± standard error (SE), and measured values and changes were evaluated. . RLP-cholesterol, phospholipid, and β-lipoprotein were secondary evaluation items.
（統計解析）
　二重盲検ランダム化クロスオーバー法の妥当性の検証は、以下の式（２）のモデルを用いた一般化線形モデル（ＧＬＭ）により行った。時期効果、順序効果に関する検討は血中中性脂肪ＡＵＣを用いて行った。 (Statistical analysis)
The validity of the double-blind randomized crossover method was verified by a generalized linear model (GLM) using the model of the following equation (2). The examination on the timing effect and the order effect was performed using blood neutral fat AUC.
　Ｙｉｊｋｌ＝μ＋αｉ＋βｊ＋γｋ＋ε（１）ｋｌ＋ε（２）ｉｊｋｌ　　　（２）
　　Ｙｉｊｋｌ（ｉ，飲料；ｊ，時期；ｋ，順序；ｌ，被験者）；
　　μ，全体平均；
　　α，飲料効果；β，時期効果；γ，順序効果；
　　ε（１），被験者の効果（被験者間のばらつき）；
　　ε（２），個々の測定値の誤差（被験者内のばらつき） Y ijkl = μ + α i + β j + γ k + ε (1) kl + ε (2) ijkl (2)
Y ijkl (i, beverage; j, time; k, order; l, subject);
μ, overall average;
α, beverage effect; β, time effect; γ, sequence effect;
ε (1) , subject effect (variation between subjects);
ε (2) , individual measurement error (variation within subject)
　血中中性脂肪ＡＵＣの時期効果、順序効果は、それぞれ、Ｐ＝０．０７５、Ｐ＝０．８３０であり、いずれも有意でなく、クロスオーバー法は適切であると判断された。 The time effect and order effect of blood neutral fat AUC were P = 0.075 and P = 0.830, respectively, which were not significant, and the crossover method was determined to be appropriate.
　被験飲料の効果は、対照飲料摂取時を比較対照とした対応ありのｔ検定により解析した。有意水準は両側検定で５％とし、統計解析ソフトはＩＢＭ　ＳＰＳＳ　Ｓｔａｔｉｓｔｉｃｓ２４（日本アイ・ビー・エム株式会社）を用いた。 The effect of the test beverage was analyzed by a paired t-test using the control beverage intake as a comparative control. The significance level was 5% by two-sided test, and the IBM SPSS Statistics 24 (Japan IBM Corporation) was used as the statistical analysis software.
（結果）
　血中中性脂肪値について、経時変化を図１、血中濃度曲線下面積（ＡＵＣ）を図２に示す。血中中性脂肪値の変化量（Δ血中中性脂肪値）について、経時変化を図３、血中濃度曲線下面積（ＡＵＣ）を図４に示す。
　血中中性脂肪値について、被験飲料摂取前及び対照飲料摂取前は、それぞれ、１４６．２±５６．０ｍｇ／ｄＬ、１４９．９±５３．８ｍｇ／ｄＬであり、有意差はみられなかった。 (result)
With respect to the blood triglyceride level, the time course is shown in FIG. 1, and the area under the blood concentration curve (AUC) is shown in FIG. Regarding the amount of change in blood triglyceride value (Δ blood triglyceride value), the change with time is shown in FIG. 3, and the area under the blood concentration curve (AUC) is shown in FIG.
The blood triglyceride level was 146.2 ± 56.0 mg / dL and 149.9 ± 53.8 mg / dL before taking the test beverage and before taking the control beverage, respectively, and there was no significant difference. .
　図１の血中中性脂肪値について、負荷食品摂取２、３、４、６時間後で、被験飲料摂取時は、対照飲料摂取時と比較して、有意に低値を示した（摂取２、４、６時間後：Ｐ＜０．０５、摂取３時間後：Ｐ＜０．０１）。
　図２の血中中性脂肪ＡＵＣについて、被験飲料摂取時は、対照飲料摂取時と比較して、有意に低値を示した（Ｐ＜０．０１）。 About the blood triglyceride level of FIG. 1, after the loading food intake 2, 3, 4, and 6 hours, the test drink ingestion showed a significantly low value compared with the control drink ingestion (Ingestion 2) 4, 6 hours later: P <0.05, 3 hours after ingestion: P <0.01).
The blood neutral fat AUC in FIG. 2 was significantly lower when the test beverage was ingested than when the control beverage was ingested (P <0.01).
　図３のΔ血中中性脂肪値について、負荷食品摂取２、３、４、６時間後で、被験飲料摂取時は、対照飲料摂取時と比較して、有意に低値を示した（摂取２、３、４時間後：Ｐ＜０．０１、摂取６時間後：Ｐ＜０．０５）。
　図４のΔ血中中性脂肪ＡＵＣについて、被験飲料摂取時は、対照飲料摂取時と比較して、有意に低値を示した（Ｐ＜０．０１）。 The Δ blood triglyceride level in FIG. 3 was significantly lower when the test beverage was ingested 2, 3, 4 and 6 hours after the ingestion of the loaded food than when the control beverage was ingested (ingestion). 2, 3, 4 hours later: P <0.01, 6 hours after ingestion: P <0.05).
About (DELTA) blood neutral fat AUC of FIG. 4, the test drink ingestion showed the significantly low value compared with the control drink ingestion (P <0.01).
　以上の結果から、還元難消化性デキストリンを配合した清涼飲料水は、食事性の脂肪による血中中性脂肪値の上昇を抑制することが示された。 From the above results, it was shown that soft drinks containing reduced indigestible dextrin suppress the increase in blood neutral fat level due to dietary fat.
　ＲＬＰ－コレステロール、リン脂質、β－リポ蛋白の経時変化を表１１に示す。表１１中、各測定項目について、上段が被験飲料の結果であり、下段が対照飲料の結果である。 Table 11 shows changes with time of RLP-cholesterol, phospholipid, and β-lipoprotein. In Table 11, for each measurement item, the upper row is the result of the test beverage, and the lower row is the result of the control beverage.
Figure JPOXMLDOC01-appb-T000011
Figure JPOXMLDOC01-appb-T000011
　ＰＬＲ－コレステロールは、負荷食品摂取６時間後で、被験飲料摂取時は、対照飲料摂取時と比較して、有意に低値を示した（Ｐ＜０．０５）。
　リン脂質は、負荷食品摂取２、４、６時間後で、被験飲料摂取時は、対照飲料摂取時と比較して、有意に低値を示した（摂取２、４時間後：Ｐ＜０．０５、摂取６時間後：Ｐ＜０．０１）。
　β－リポ蛋白は、負荷食品摂取２、３、４、６時間後で、被験飲料摂取時は、対照飲料摂取時と比較して、有意に低値を示した（摂取２、３、４時間後：Ｐ＜０．０５、摂取６時間後：Ｐ＜０．０１）。 PLR-cholesterol was significantly lower (P <0.05) 6 hours after ingestion of the loaded food and when the test beverage was ingested than when the control beverage was ingested.
Phospholipids showed significantly lower values after ingestion of the loaded food at 2, 4 and 6 hours and at the time of ingestion of the test beverage compared to the intake of the control beverage (2, 4 hours after ingestion: P <0. 05, 6 hours after ingestion: P <0.01).
β-lipoprotein showed a significantly lower value when the test beverage was ingested 2, 3, 4 and 6 hours after ingestion of the loaded food compared to the intake of the control beverage ( ingestion 2, 3, 4 hours). After: P <0.05, 6 hours after ingestion: P <0.01.
　食事性の脂肪は、腸管から吸収された後、小腸上皮細胞で中性脂肪を多く含むカイロミクロンに再合成され血中に移行し、食後血中中性脂肪値は上昇する。カイロミクロンは、リポ蛋白リパーゼによりカイロミクロンレムナントへと異化され、肝臓に取り込まれる。このとき生じる中間代謝物であるレムナント様リポ蛋白が血中に滞留することが、動脈硬化発現の原因となるとの研究報告がなされている。したがって、食後の血中中性脂肪値に加え、レムナント様リポ蛋白を反映するＲＬＰ－コレステロールの上昇を抑制すること、また、脂肪の代謝に関係し動脈硬化の一因と考えられる物質であるリン脂質、β－リポ蛋白の上昇を抑制することは、動脈硬化性疾患予防に有用と考えられる。 Dietary fat is absorbed from the intestinal tract and then re-synthesized into chylomicron containing a large amount of neutral fat in small intestinal epithelial cells and transferred into the blood. Chylomicron is catabolized into a chylomicron remnant by lipoprotein lipase and taken into the liver. Research reports that remnant-like lipoprotein, an intermediate metabolite produced at this time, stays in the blood cause the development of arteriosclerosis. Therefore, in addition to postprandial blood triglyceride levels, it suppresses the rise in RLP-cholesterol reflecting remnant-like lipoproteins, and is a substance that is considered to contribute to arteriosclerosis related to fat metabolism. Suppressing the rise of lipids and β-lipoprotein is considered useful for preventing arteriosclerotic diseases.
　被験者について、空腹時血中中性脂肪値が１５０ｍｇ／ｄＬ以上の被験者と、１５０ｍｇ／ｄＬ未満の被験者に層別し、層別解析を行った。
　空腹時血中中性脂肪値が１５０ｍｇ／ｄＬ以上の被験者（ｎ＝３８）では、血中中性脂肪値は、被験飲料及び対照飲料摂取前は、それぞれ、１６５．１±６６．４ｍｇ／ｍＬ、１７０．４±５８．１ｍｇ／ｍＬであり、有意差は認められなかった。負荷食品摂取後の血中中性脂肪値は、被験飲料摂取時は、対照飲料摂取時と比較して、負荷食品摂取２、３、４、６時間後で低値を示す傾向がみられた（摂取２時間後：Ｐ＝０．０５７、摂取３時間後：Ｐ＝０．０７６、摂取４時間後：Ｐ＝０．０５７、摂取６時間後：Ｐ＝０．０５４）。Δ血中中性脂肪値は、被験飲料摂取２、３、４、６時間後では、対照飲料摂取時と比較して、有意な低値を示した（摂取２、３、４、６時間後：Ｐ＜０．０５）。被験飲料摂取時の血中中性脂肪ＡＵＣは、対照飲料摂取時と比較して低値を示す傾向がみられ（Ｐ＝０．０５４）、Δ血中中性脂肪ＡＵＣは、被験飲料摂取時に、対照飲料摂取時と比較して有意な低値を示した（Ｐ＜０．０１）。 The subjects were stratified into a subject having a fasting blood neutral fat value of 150 mg / dL or more and a subject having a fasting blood triglyceride value of less than 150 mg / dL, and a stratified analysis was performed.
For subjects with fasting blood triglyceride values of 150 mg / dL or higher (n = 38), blood triglyceride levels were 165.1 ± 66.4 mg / mL, respectively, before ingesting the test and control beverages. 170.4 ± 58.1 mg / mL, and no significant difference was observed. The blood triglyceride level after ingestion of the loaded food tended to show a lower value when the test beverage was ingested, after 2, 3, 4, and 6 hours of ingestion of the ingested food compared to the intake of the control beverage (2 hours after ingestion: P = 0.057, 3 hours after ingestion: P = 0.076, 4 hours after ingestion: P = 0.057, 6 hours after ingestion: P = 0.054). ΔThe blood triglyceride level was significantly lower at 2, 3, 4, and 6 hours after ingestion of the test beverage than at the time of ingestion of the control beverage (after 2, 3, 4, and 6 hours of ingestion). : P <0.05). The blood neutral fat AUC at the time of ingesting the test beverage tended to show a lower value than that at the time of ingesting the control beverage (P = 0.054), and the Δ blood neutral fat AUC at the time of ingesting the test beverage The value was significantly lower than that of the control drink (P <0.01).
　空腹時血中中性脂肪値が１５０ｍｇ／ｄＬ未満の被験者（ｎ＝５１）では、血中中性脂肪値は、被験飲料及び対照飲料摂取前は、それぞれ、１３２．１±４２．２ｍｇ／ｍＬ、１３４．６±４５．３ｍｇ／ｍＬであり、有意差は認められなかった。負荷食品摂取後の血中中性脂肪値は、被験飲料摂取時は、対照飲料摂取時と比較して、負荷食品摂取３、４時間後で低値を示す傾向がみられた（摂取３時間後：Ｐ＝０．０５６、摂取４時間後：Ｐ＝０．０８９）。Δ血中中性脂肪値は、被験飲料摂取３時間後では、対照飲料摂取時と比較して、有意な低値を示し（Ｐ＜０．０５）、２、４時間後では、対照飲料摂取時と比較して、低値を示す傾向がみられた（摂取２時間後：Ｐ＝０．０５７、摂取４時間後：Ｐ＝０．０５６）。被験飲料摂取時の血中中性脂肪ＡＵＣは、対照飲料摂取時と比較して低値を示す傾向がみられ（Ｐ＝０．０６９）、Δ血中中性脂肪ＡＵＣは、被験飲料摂取時に、対照飲料摂取時と比較して有意な低値を示した（Ｐ＜０．０５）。 For subjects with fasting blood triglyceride levels of less than 150 mg / dL (n = 51), blood triglyceride levels were 132.1 ± 42.2 mg / mL, respectively, before ingesting the test and control beverages. 134.6 ± 45.3 mg / mL, and no significant difference was observed. The blood triglyceride level after ingestion of the load food tended to show a lower value when the test beverage was ingested than after the intake of the control beverage 3 and 4 hours after ingestion of the load food (3 hours of ingestion). After: P = 0.056, 4 hours after ingestion: P = 0.089). ΔThe blood triglyceride level was significantly lower at 3 hours after ingesting the test beverage than at the time of ingesting the control beverage (P <0.05), and after 2, 4 hours, the control beverage was ingested. Compared with time, there was a tendency to show a low value (2 hours after ingestion: P = 0.057, 4 hours after ingestion: P = 0.056). The blood neutral fat AUC at the time of ingestion of the test beverage tended to show a lower value than that at the time of ingestion of the control beverage (P = 0.069). The value was significantly lower than that of the control drink (P <0.05).
　以上から、被験飲料を食前に摂取することで、空腹時血中中性脂肪値が正常高値域からやや高めの成人男女だけでなく、空腹時血中中性脂肪値が基準値内の成人男女に対しても、食後血中中性脂肪値上昇抑制効果が期待できることが示された。 From the above, by taking the test beverage before meals, not only adult men and women whose fasting blood triglyceride level is slightly higher than the normal high level, but also adult men and women whose fasting blood triglyceride value is within the reference value In contrast, it was shown that an effect of suppressing the increase in blood triglycerides after meals can be expected.
　本発明によれば、還元難消化性デキストリンを含む飲料水において、飲みやすさを向上させることができる。また、本発明によれば、脂肪吸収抑制という機能を付与した還元難消化性デキストリンを含む飲料水を提供できる。
　飲料水は普段の食生活に無理なく組み入れ摂取することが可能であり、本発明の脂肪吸収抑制用の飲料水を継続的・習慣的に摂取することにより、食後高脂血症や生活習慣病の予防にも有効であると考えられる。 ADVANTAGE OF THE INVENTION According to this invention, the ease of drinking can be improved in the drinking water containing a reduced indigestible dextrin. Moreover, according to this invention, the drinking water containing the reduced indigestible dextrin which provided the function of fat absorption suppression can be provided.
Drinking water can be comfortably incorporated and consumed in normal eating habits, and by continuously and regularly ingesting the drinking water for inhibiting fat absorption of the present invention, postprandial hyperlipidemia and lifestyle-related diseases It is thought that it is also effective for prevention.
　上記に本発明の実施形態及び／又は実施例を幾つか詳細に説明したが、当業者は、本発明の新規な教示及び効果から実質的に離れることなく、これら例示である実施形態及び／又は実施例に多くの変更を加えることが容易である。従って、これらの多くの変更は本発明の範囲に含まれる。
　この明細書に記載の文献及び本願のパリ優先の基礎となる日本出願明細書の内容を全てここに援用する。 Although several embodiments and / or examples of the present invention have been described in detail above, those skilled in the art will appreciate that these exemplary embodiments and / or embodiments are substantially without departing from the novel teachings and advantages of the present invention. It is easy to make many changes to the embodiment. Accordingly, many of these modifications are within the scope of the present invention.
The contents of the documents described in this specification and the specification of the Japanese application that is the basis of Paris priority of the present application are all incorporated herein.

Claims (17)

  1. 　還元難消化性デキストリンを含む飲料水であって、硬度が１０～１１０である前記飲料水。 Drinking water containing reduced indigestible dextrin and having a hardness of 10 to 110.
  2. 　前記飲料水中のマグネシウムに対するカルシウムの重量比（Ｃａ／Ｍｇ）が１～８である請求項１に記載の飲料水。 The drinking water according to claim 1, wherein the weight ratio of calcium to magnesium (Ca / Mg) in the drinking water is 1-8.
  3. 　前記飲料水中の還元難消化性デキストリンの用量が飲料水５００ｇあたり１～１６ｇである請求項１又は２に記載の飲料水。 The drinking water according to claim 1 or 2, wherein the dose of the reduced resistant digestible dextrin in the drinking water is 1 to 16 g per 500 g of drinking water.
  4. 　無色透明である、請求項１～３のいずれかに記載の飲料水。 The drinking water according to any one of claims 1 to 3, which is colorless and transparent.
  5. 　天然水を含む、請求項１～４のいずれかに記載の飲料水。 The drinking water according to any one of claims 1 to 4, comprising natural water.
  6. 　還元難消化性デキストリンを配合した飲料水の飲みやすさを向上させる方法であって、
    　前記飲料水の硬度を調節することを含む前記方法。     A method of improving the ease of drinking drinking water containing reduced indigestible dextrin,
    Adjusting the hardness of the drinking water.
  7. 　前記飲料水の硬度を１０～１１０に調節する、請求項６に記載の方法。 The method according to claim 6, wherein the hardness of the drinking water is adjusted to 10 to 110.
  8. 　前記飲料水中のマグネシウムに対するカルシウムの重量比（Ｃａ／Ｍｇ）が１～８である、請求項７に記載の方法。 The method according to claim 7, wherein the weight ratio of calcium to magnesium (Ca / Mg) in the drinking water is 1-8.
  9. 　マグネシウム塩及びカルシウム塩の少なくとも一方を添加することにより、前記飲料水の硬度を調節する、請求項６～８のいずれかに記載の方法。 The method according to any one of claims 6 to 8, wherein the hardness of the drinking water is adjusted by adding at least one of a magnesium salt and a calcium salt.
  10. 　硬度の異なる複数種の水を配合することにより、前記飲料水の硬度を調節する、請求項６～９のいずれかに記載の方法。 The method according to any one of claims 6 to 9, wherein the hardness of the drinking water is adjusted by blending a plurality of types of water having different hardnesses.
  11. 　前記飲料水中の還元難消化性デキストリンの用量が飲料水５００ｇあたり１～１６ｇである、請求項６～１０のいずれかに記載の方法。 The method according to any one of claims 6 to 10, wherein a dose of the reduced resistant digestible dextrin in the drinking water is 1 to 16 g per 500 g of drinking water.
  12. 　還元難消化性デキストリンを含む脂肪吸収抑制用の飲料水。 Drinking water for fat absorption suppression containing reduced indigestible dextrin.
  13. 　前記飲料水の硬度が１０～１１０である、請求項１２に記載の脂肪吸収抑制用の飲料水。 The drinking water for fat absorption suppression according to claim 12, wherein the drinking water has a hardness of 10 to 110.
  14. 　前記飲料水中のマグネシウムに対するカルシウムの重量比（Ｃａ／Ｍｇ）が１～８である、請求項１３に記載の脂肪吸収抑制用の飲料水。 The drinking water for inhibiting fat absorption according to claim 13, wherein the weight ratio of calcium to magnesium (Ca / Mg) in the drinking water is 1 to 8.
  15. 　前記飲料水中の還元難消化性デキストリンの用量が飲料水５００ｇあたり１～１６ｇである、請求項１２～１４のいずれかに記載の脂肪吸収抑制用の飲料水。 The drinking water for inhibiting fat absorption according to any one of claims 12 to 14, wherein a dose of the reduced indigestible dextrin in the drinking water is 1 to 16 g per 500 g of drinking water.
  16. 　無色透明である、請求項１２～１５のいずれかに記載の飲料水。 The drinking water according to any one of claims 12 to 15, which is colorless and transparent.
  17. 　食事性の脂肪吸収を抑制するための方法であって、
    　還元難消化性デキストリン５ｇを含む脂肪吸収抑制用の飲料水５５５ｍＬを食事と一緒に１日１回摂取することを含む前記方法。     A method for suppressing dietary fat absorption,
    The said method including ingesting 555 mL of the drinking water for fat absorption suppression containing 5 g of reduced indigestible dextrins with a meal once a day.
PCT/JP2017/035451 2016-09-30 2017-09-29 Method for improving drinkability of drinking water to which reduced indigestible dextrin has been added, drinking water to which reduced indigestible dextrin has been added in which drinkability is improved by said method, drinking water for inhibiting fat absorption containing reduced indigestible dextrin, and method for inhibiting dietetic fat absorption WO2018062474A1 (en)

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CN201780060590.9A CN109819647A (en) 2016-09-30 2017-09-29 Improve the method for the Yi Yindu of drinking water of reduction indigestible dextrins that is combined with, by the way that the method increase the drinking water for being combined with reduction indigestible dextrins of Yi Yindu, the drinking water containing the fat absorption inhibition for restoring indigestible dextrins and the methods for inhibiting dietary fat to absorb
KR1020197007046A KR20190062393A (en) 2016-09-30 2017-09-29 A method of improving the easy-to-drink degree of the drink containing the reduced indigestible dextrin, a drink containing the reduced indigestible dextrin improved in the degree to which it is easily ingested by the method, a drink for suppressing the fat absorption containing the reduced indigestible dextrin, For inhibiting fat absorption

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005287454A (en) * 2004-04-02 2005-10-20 Matsutani Chem Ind Ltd Food and beverage for imparting health function and method for imparting health function to food and beverage
JP2009286697A (en) * 2008-05-27 2009-12-10 Goshu Yakuhin Kk Functional drinking water
JP2015211689A (en) * 2015-07-09 2015-11-26 正明 林原 Mineral adjustment water and production method thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004113150A (en) * 2002-09-27 2004-04-15 Marine Bio Kk Composition for beverage for supplementing mineral and drinking water for supplementing mineral
CN101043894B (en) * 2004-10-08 2011-12-14 松谷化学工业株式会社 Agent for inhibiting postprandial increase in blood neutral fat level and foods containing the same
JP2007291136A (en) * 2007-07-31 2007-11-08 Matsutani Chem Ind Ltd Body fat regulator containing reduced hard-digestive dextrin
KR20110014744A (en) * 2009-08-06 2011-02-14 박귀조 Method to produce a drinking-water from the deep seawater or the surface seawater
CN101698546A (en) * 2009-10-31 2010-04-28 卢发平 Water processor for conditioning content of mineral substances of water

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005287454A (en) * 2004-04-02 2005-10-20 Matsutani Chem Ind Ltd Food and beverage for imparting health function and method for imparting health function to food and beverage
JP2009286697A (en) * 2008-05-27 2009-12-10 Goshu Yakuhin Kk Functional drinking water
JP2015211689A (en) * 2015-07-09 2015-11-26 正明 林原 Mineral adjustment water and production method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Launching of ''HOUSE Delicious Water of Dietary Fiber", THE JAPAN FOOD JOURNAL, 28 February 2003 (2003-02-28) *
KANEHIRA, TSUTOMU ET AL.: "A clinical study for evaluating the efficacy of soft drink containing reduced type of indigestible dextrin on the suppression of the elevation of postprandial serum triglyceride", JPN PHARMACOL THER, vol. 44, no. 11, November 2016 (2016-11-01), pages 1629 - 1638 *

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