WO2018051145A3 - Integrated broad-band young interferometers for simultaneous dual polarization bio-chemical sensing through amplified fringe packet shifts - Google Patents

Integrated broad-band young interferometers for simultaneous dual polarization bio-chemical sensing through amplified fringe packet shifts Download PDF

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Publication number
WO2018051145A3
WO2018051145A3 PCT/GR2017/000053 GR2017000053W WO2018051145A3 WO 2018051145 A3 WO2018051145 A3 WO 2018051145A3 GR 2017000053 W GR2017000053 W GR 2017000053W WO 2018051145 A3 WO2018051145 A3 WO 2018051145A3
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WO
WIPO (PCT)
Prior art keywords
chip
polarization
broad
packet
interferometers
Prior art date
Application number
PCT/GR2017/000053
Other languages
French (fr)
Other versions
WO2018051145A2 (en
Inventor
Konstantinos Misiakos
Eleni Makarona
Ionnis RAPTIS
Sotirios Kakabakos
Panagiota Petrou
Alexandros SALAPATAS
Eleftheria STAVRA
Original Assignee
National Centre For Scientific Research "Demokritos" (Ncsr "Demokritos")
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Application filed by National Centre For Scientific Research "Demokritos" (Ncsr "Demokritos") filed Critical National Centre For Scientific Research "Demokritos" (Ncsr "Demokritos")
Publication of WO2018051145A2 publication Critical patent/WO2018051145A2/en
Publication of WO2018051145A3 publication Critical patent/WO2018051145A3/en

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
    • G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
    • G02B6/12007—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind forming wavelength selective elements, e.g. multiplexer, demultiplexer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
    • G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7779—Measurement method of reaction-produced change in sensor interferometric
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
    • G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
    • G02B2006/12133—Functions
    • G02B2006/12138—Sensor
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
    • G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
    • G02B2006/12133—Functions
    • G02B2006/12159—Interferometer

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

The photonic chip integrates one or more Young interferometers that accept broad-band light at their input waveguide while their output waveguides couple their light to a single imaging array either through air or through on-chip slab waveguides. The interferometers are interpolated between the input and output waveguides. The sensing window is exposed to the analyte solutions. On this window the recognition molecules have previously being immobilized. Upon analyte binding an adlayer grows on the sensing window. Depending on emitted light polarization, interference occurs at specific solid angles so that two packets of sinusoidal fringes are formed for either polarization: One for the TE and one for the TM polarization. The two different angles result from the different dispersion relationship of the phase function on the wavenumber for the two polarizations. With the development of adlayers the fringes shift in each packet following the on- chip phase change for each polarization. In addition to the fringe shift and in the same direction, each packet moves solidly as a result of the adlayer induced changes on the phase function slope against the wavenumber. In fact, the packets move faster than the on-chip phase change thus providing an amplified optical signal. The set-up incorporates the photonic chip with the broad¬ band Young interferometer and the input and output waveguides, broad-band light sources, external or on-chip integrated, and an imaging array, external or on-chip integrated. It also includes fluidic structures for the supply of reagents and the samples. Fourier transform and other techniques are employed to calculate the phase change from the fringe shift and packet motion. The packet motion and phase shifts provide a measure of the adlayer growth due to binding reactions.
PCT/GR2017/000053 2016-09-14 2017-09-11 Integrated broad-band young interferometers for simultaneous dual polarization bio-chemical sensing through amplified fringe packet shifts WO2018051145A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GR20160100477A GR20160100477A (en) 2016-09-14 2016-09-14 Integrated broad-band young interferometers for simultaneous dual polarization bio-chemical sensing through amplified fringe packet shifts
GR20160100477 2016-09-14

Publications (2)

Publication Number Publication Date
WO2018051145A2 WO2018051145A2 (en) 2018-03-22
WO2018051145A3 true WO2018051145A3 (en) 2018-04-26

Family

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Family Applications (1)

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PCT/GR2017/000053 WO2018051145A2 (en) 2016-09-14 2017-09-11 Integrated broad-band young interferometers for simultaneous dual polarization bio-chemical sensing through amplified fringe packet shifts

Country Status (2)

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GR (1) GR20160100477A (en)
WO (1) WO2018051145A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012225A1 (en) * 1995-09-29 1997-04-03 Georgia Tech Research Corporation Integrated optic interferometric sensor
US20020003627A1 (en) * 2000-03-13 2002-01-10 Rieder Ronald J. Doubly-differential interferometer and method for evanescent wave surface detection
WO2011053147A1 (en) * 2009-11-02 2011-05-05 Ostendum Holding B.V. Method for detection of an analyte in a fluid sample

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012225A1 (en) * 1995-09-29 1997-04-03 Georgia Tech Research Corporation Integrated optic interferometric sensor
US20020003627A1 (en) * 2000-03-13 2002-01-10 Rieder Ronald J. Doubly-differential interferometer and method for evanescent wave surface detection
WO2011053147A1 (en) * 2009-11-02 2011-05-05 Ostendum Holding B.V. Method for detection of an analyte in a fluid sample

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SAVRA ELEFTHERIA ET AL: "Monolithically-integrated Young interferometers for label-free and multiplexed detection of biomolecules", SPIE - INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING. PROCEEDINGS, S P I E - INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, US, vol. 9752, 14 March 2016 (2016-03-14), pages 97520N - 97520N, XP060067720, ISSN: 0277-786X, ISBN: 978-1-5106-0753-8, DOI: 10.1117/12.2209011 *
STAMM C ET AL: "Biosensing with the integrated-optical difference interferometer: dual-wavelength operation", OPTICS COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 153, no. 4-6, 1 August 1998 (1998-08-01), pages 347 - 359, XP004146376, ISSN: 0030-4018, DOI: 10.1016/S0030-4018(98)00194-1 *

Also Published As

Publication number Publication date
GR20160100477A (en) 2018-05-18
WO2018051145A2 (en) 2018-03-22

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