WO2018050453A1

WO2018050453A1 - Medical device having a surface with self-disinfecting property

Info

Publication number: WO2018050453A1
Application number: PCT/EP2017/071955
Authority: WO
Inventors: Rainer Kuth; Stefan Popescu; Philipp Treffer
Original assignee: Siemens Healthcare Gmbh
Priority date: 2016-09-15
Filing date: 2017-09-01
Publication date: 2018-03-22
Also published as: DE102016217571A1; CN211132318U

Abstract

In order to reduce the risk of infection in medical establishments, the surface (10, 15) of a medical device (6, 7) having a surface (10, 15) that runs the risk of being contaminated is provided with a self-disinfecting property. For this purpose, the surface (10, 15) is provided with a coating (11, 16) that substantially consists of graphene oxide or a graphene oxide-containing composite material, or a component of the medical device (7) comprising the surface (10) is manufactured from a graphene oxide-containing composite material.

Description

description

Medical device with a surface with autodesin ^¬ fektionswirkung

The invention relates to a medical device having a surface with auto-disinfecting action. The invention further relates to a method of manufacturing the medical device.

Certain surfaces in medical facilities, such as hospitals or medical practices, are easily contaminated by their regular contact with patients (generally persons). For example, surfaces of patient beds, surfaces of large equipment such as computer tomographs (CT) or magnetic resonance tomographs are affected

(MRT), but also surfaces of small devices such as coil devices for an MRI or control devices. As contamination here is below contamination by micro-organisms such as bacteria, fungi or viruses be ^¬ records.

Such contaminations are known to present a risk of infection for the persons present in the affected medical facility. In particular, so-called hospital germs such as multi-drug resistant bacteria such as MRSA (multi-resistant Staphylococcus aureus) and fungi are a widespread problem in medical facilities. In addition to the health consequences for the person affected by an infection, the affected medical facility also incurs substantial additional costs as a result of the infection. a significant economic loss.

In order to avoid carryover of microorganisms by a contact transmission, especially surfaces that come into direct contact with a patient are regularly disinfected. Large equipment is usually chemically disinfected by a spray, for example, alcoholic or surfactant-containing disinfectant is sprayed onto the surface and wiped on closing ^¬ . The surfaces of reusable invasive medical instruments, such as endoscopes, are conventionally thermally disinfected by steam sterilization.

Furthermore, a surface coating with a titanium dioxide ceramic in combination with a UV irradiation for the disinfection of surfaces is proposed (KLIEMANN, JANOLIVER et al.: "Titanium dioxide ceramics against bacteria - antibacterial surfaces by photocatalysis", in: Ceramic Journal 01/2011, No. 63, Pages 31-34).

The object of the invention is to effectively reduce the risk of infection in medical facilities with comparatively simple means. This object is achieved by a medical device having the features of claim 1. Regarding a method for producing the medical device, the object is achieved by the features of claim 7. Advantageous and in part inventive Ausführungsfor ^¬ men and further developments of the invention set forth in the subclaims and the description below.

The medical device according to the invention comprises a potentially contaminable surface, ie a surface which, in its intended installation situation, could possibly come into contact with microbial contaminants. In order to prevent a transfer of contaminants over that surface, or at least largely to mini ^¬ mieren, this surface is formed with a car disinfection effect. Autodesinfektionswirkung is the property of the surface referred to eliminate at least a portion of the microorganisms that come into contact with the surface, automatically, without an additional disinfection step must be performed. Erfindungsge- is measured to generate the car disinfecting effect in a first variant, the surface with a coating shipping ^¬ hen, the composite material containing essentially of graphene oxide or graphene oxide is one. The coating preferably has a thickness of few micrometers, at ^¬ play, about 15 microns. In a second variant of the invention, a component of the medical device comprising the surface is produced from a composite material containing graphene oxide.

In the course of the method for the production of the medical device, the body of the medical device is first produced correspondingly in a first variant of the method. The body of the medical device is made in particular of plastic, silicone, metal or an alloy. Subsequently, the potentially contaminable surface is provided with a coating consisting essentially of graphene oxide or a graphene oxide-containing composite material. In a second variant of the method, a component of the medical device which comprises the potentially contaminable surface is produced from a graphoxide-containing composite material. The autodesin ^¬ fektionswirkung the surface is immanent the body of the medical device.

In the following, "graphene oxide" refers to a substance which consists essentially of graphite oxide which is monomolecular

Layer thickness is present. Graphene has as radio ^¬ tional groups Epoxy (1, 2-ether) -, hydroxyl and carboxyl groups, and tertiary alcohols on. The production of

Graphene is known in principle and carried beispielswei ^¬ se according to a modified, originally from Hummers

Proposed method of flake graphite (: "Preparation of Graphitic Oxi ^¬ de" in... J. Am Chem Soc, March 20, 1958 Volume 80, No. 60, page 1339 HUMMER, WILLIAM S. et al.)

(engl., "flake graphite") (DREYER, DANIEL R. et al .: "The chemistry of graphene oxides", in: Chem. Soc. Rev., 2010, Vol. 39, No. 1, pages 228-240). A protocol for the production of Graphene oxide is found in REI ELSHÖFER, SEBASTIAN et al. "Stacked Dielectric Elastomer Actuators", SPIE Conference Paper, March 2016. Commercially available graphene oxide at ^¬ play, at Sigma-Aldrich product number 794341 as an aqueous suspension.

In laboratory experiments, it was shown exemplary for several bacterial strains and Pil ^¬ ze that graphene develops a biocidal effect for this. It shows insbeson ^¬ particular be advantageous that is graphene relatively simply and inexpensive to manufacture.

Graphene oxide is also known to have a sheet resistivity in the range of 10 terrahms, so graphene oxide is considered to be an electrical insulator (see ZHAO, JINPING et al.: Efficient Preparation of Large Area Graphene Oxide Sheets for Transparent Conductive Films ", in: ACSNANO, 2010, Vol. 4, No. 9, pages 5245-5252; BECERRIL, HECTOR A. et al.:" Evaluation of Soluti- on-Processed Reduced Graphene Oxide Films as Transparent Conductors ", in: ACSNANO, 2008, Volume 2, No. 3, pages 463-

470). As a result, graphene oxide is advantageously as compatible for magnetic resonance imaging (MRI).

In addition, graphene oxide interacts only to a comparatively small extent with X-ray radiation, so that a graphene oxide-containing material is also advantageously suitable for use in X-ray machines, for example computer tomographs (CT). Advantageously, therefore, the inventive Before ^¬ direction created in a comparatively simple manner, a way to minimize the risk of infections in medical facilities, with the invention executed before ^¬ direction advantageously is nevertheless suitable for use in MRI and CT.

In a particularly preferred embodiment, the graphene oxide is included to enhance its adhesion properties Silicon (Si) or silicon monoxide (SiO) doped. However, the OF INVENTION ^¬ dung is not limited to the use of silicon or silicon monoxide, the doping can be carried out properties prinzipi ^¬ ell with another substance with similar chemical egg.

The doping causes the binding forces between a ^¬ individual Graphenoxidlagen compared to the otherwise predominant Van-der-Waals forces are increased, whereby Si is chergestellt that the graphene without wei ^¬ teres of a further Graphenoxidlage from (potentially contaminatable) surface or can be replaced by a matrix material contained in the composite material. In a preferred embodiment, the medical device is designed as a cover, as a cover or as a coating of a medical device, wherein the me ^¬ medical device in turn in particular

as a patient couch and / or an associated component,

as an imaging device, in particular an MRI or CT device, and / or an associated component, as a furnishing of a medical room, as a wall, floor or ceiling panel of a medical room, and / or

as an input, display or control device

is trained.

In particular, as a reusable, invasive instrument - - In an alternative embodiment, the medical device as a medical instrument is ausgebil ^¬ det, for example, as an endoscope, or as a chirurgi ^¬ policy tool such as a scalpel, a clip, a pin, etc.

Again alternatively, the medical device is designed as a pad, especially for single use, for a patient bed. Preferably, the support comprises tuen a first layer of a hydrophobic and liquid ^¬ keitsdichten fabric, which is connected in area with a second layer of a liquid-receiving substance, wherein the liquid-receiving layer is in turn provided with a coating containing graphene oxide.

In a preferred embodiment of the production method, the graphenoxidoxidigeige coating is applied by means of an aerosol printer (in the aerosol jet method) or by means of an inkjet printer (inkj et method) on the upper ^¬ surface of the device.

In this case, in a ^{variant of the} method, a first aerosol is generated from a matrix material (present as liquid), a second aerosol stream being produced from a suspension containing graphene oxide. To produce a graphenoxidoxidhaltigen coating, the two aerosol streams are applied together on the surface of the medical device. The joint application can take place both at the same time, in particular by mixing the two aerosol streams before the application, as well as alternately, so that matrix material and graphene oxide are applied quasi-layer by layer. As the matrix material is a silicone, insbesonde re ^¬ a silicone elastomer is preferably used. Graphene oxide is suspended in a ^¬ simplest case, in water. In an alternative embodiment, graphene oxide is suspended in a volatile organic solvent or solvent mixture such as propanol and / or terpineol to produce the graphene oxide-containing suspension.

In the context of the invention, however, it is also possible that the coating is applied by other methods, for example by means of rollers.

The invention further relates to a graphene oxide-containing composite material suitable for use in a medical zine device is used according to the above description. The composite material (also referred to as a composite material) comprises graphene oxide which is embedded as a filler in a matrix material, wherein the matrix material is in particular a resin, preferably a synthetic resin, or a metal or an alloy the invention is graphene oxide as a particulate (nanoscale) filler before. in an alternate embodiment, matrix material and graphene are arranged in alternating layers. the composite material is extensive in the invention optionally for coating a potentially contaminatable surface or for preparing a potentially contaminatable surface construction ^¬ partly used.

Embodiments of the invention will be explained in more detail with reference to a drawing. Show:

1 shows a schematic representation of a CT system including a CT apparatus with a graphenoxidhaltigen coating, as well as a patient couch on which a top sheet is placed with egg ^¬ ner graphenoxidhaltigen coating,

2 shows a detail of the overlay cloth according to FIG. 1 in cross-section, and FIG

3 and FIG 4 each show a schematic illustration

Aerosol printer, where the two aerosol printers are used to produce the graphene oxide-containing coating.

Corresponding parts and materials are always provided in all figures with the same reference numerals. FIG. 1 shows a schematic representation of a computed tomography system (CT system 1 for short) comprising a computed tomography device (CT device 2) and a patient table 3. The patient table 3 comprises a stationary foot 4, as well as a patient couch 5 longitudinally displaceable relative to the foot for supporting a patient to be examined (generally an examination subject). On the patient bed 5 a support cloth 6 is arranged. This overlay cloth 6 is designed as a disposable product, wherein a new overlay cloth 6 is placed on the patient couch 5 before each examination.

The CT device 2 comprises a plastic housing 7, which is penetrated by a tunnel-like opening 8. The CT device 2 is used in a conventional manner for generating sectional images of the patient on the patient couch 5 stored. Since the operation of the CT system 1 is not relevant to the invention, will not be discussed further here. The CT system 1 is located, for example, in a sub ^¬ examination room of a hospital. To counteract the always inherent in a hospital environment danger of taking place via device surfaces transmission of pathogens, various surfaces of the CT system 1 are realized with a Autodesinfektionswirkung.

For this purpose, for example, the outwardly facing surface 10 of the plastic housing 7 is completely provided with a coating 11 which contains graphene oxide.

Furthermore, the support cloth 6 is also provided on its intended to the patient facing surface 15 with a coating 16 which contains graphene oxide. The construction of the support cloth 6 is in FIG 2 in cross-section ge ^¬ shows. The support cloth 6 comprises a first (intended to the patient bed 5 facing) layer 20 of a hydrophobic ^¬ ben, waterproof material, for example polyethylene. Egg- A second layer 21, which is ^adhesively bonded to the first layer 20 over a large area, for example by adhesive ^bonding , is provided from a water-absorbing substance, for example cellulose or paper. The surface 15 of the second layer 21 is coated with the coating 16. The coating 16 - ie the functional layer - has a thickness of about 15 ym. In principle, it is also conceivable that the (the patient bed facing lower ^¬ side of the support cloth) is also provided analogous to the top with a coating.

The manufacture of the plastic housing 7 according to a first embodiment is explained below. First, the individual housing parts (side walls or a ge frontseiti- the tunnel comprehensive pivotable cover) in a conventional way in itself produced as molded plastic parts in injection molding ^¬ process. Subsequently, the respective upper ^¬ surface 10 is provided with the coating 11 containing graphene.

The coating 11 is applied in alternating layers of a matrix material and graphene oxide. For this purpose, 3 very schematically shown aerosol printer 30 applied with ^¬ means of a in FIG said matrix material, while the graphite is applied by a phenoxide in FIG 4 second aerosol printer 40 also roughly schematically illustrated.

The aerosol printer 30 comprises according to FIG 3 in known manner a first sprayer 31, a second atomizer 32, and a print head 33, to which the two Zerstäu ^¬ about 31, 32 by means of two spray pipes 34, 35 via a Y -Weiche are coupled. Each atomiser 31, 32 each comprises ^¬ weils a compressed air connection 36 for the introduction of compressed air for pneumatic L aerosol generation. The print head 33 also includes a compressed air port 37 for introducing compressed air L as a focusing gas ("sheath gas"). In the first atomizer 31, a first component A of the Mat ^¬ rixmaterials is held, while in the second atomizer 32, a second component B of the matrix material is kept. As a matrix material, for example, the commercially available two-component silicone elastomer Elastosil P.

7670 used by the company Wacker. Both components A, B lie ^¬ gen in liquid form. Optionally, the two atomizers 31, 32 are heated to increase the viscosity of the two components.

The aerosol printer 40 according to FIG. 4 is constructed essentially analogously to the aerosol printer 30 described above, but comprises only a single atomizer 41, which is coupled to a print head 44 via an aerosol line 42. The atomizer 41 is designed here as an ultrasonic atomizer, and correspondingly comprises an ultrasound generator 45 for generating aerosol. The compressed air L connected to the atomizer 40 via a compressed air connection 46 serves in the present case as a transport gas.

In the atomizer 41 a suspension C is held. The suspension C consists of a mixture of propanol and terpinol in a mixing ratio of about 90:10, in which graphene oxide is suspended at a concentration of at most about 12% by mass. The production of graphene oxide takes place according to the so-called "liquid phase exfoliation process".

As suspension C, the commercially available aqueous suspension of graphene oxide with product number 794341 from Sigma-Aldrich is optionally used ("Graphene oxide - 15-20 sheets, 4-10% edge-oxidized, 1 mg / ml, dispersion in H 2 O"). ,

In the course of the coating process is alternately applied to the surface 10 in each case with the aid of the first aerosol printer 30 a layer of the matrix material and with the aid of the second Ae ^¬ rosol printer 40 has a layer of graphene. To apply the matrix material, the components A, B are pneumatically aerosolized to aerosols A 'and B' and mixed in the print head 33, wherein the two components A and B harden when the aerosol streams A ', B' hit the surface 10 to form the matrix material ,

For applying the analog Graphenoxidschicht the Suspen ^¬ sion C ', where aerosolized ^¬ wherein in the aerosol stream C' is by means of ultrasound to form an aerosol C contained liquid fraction is evaporated onto the surface 10 on impact, so that a Graphenoxidschicht deposited. The use of ultra ^¬ sound in the atomizer 41 has the side effect that forms a stable suspension in the nebulizer 41, so that a discontinuation of the graphene oxide particles is avoided.

Concrete parameters of the printing process, such as a ^¬ Asked compressed air streams can Reiteishöfer S. et al. , "Stacked Dielectric Elastomer Actuators", Conference Paper SPIE, March 2016.

Since the graphene oxide is doped with silicon as described above, peeling of individual graphene oxide layers is surely prevented by, for example, an adhesive tape. The peeling of graphene layers through an adhesive strip is known as "micromechanical cleavage" or "mechanical exfoliation" method or as "scotch tape method".

Alternatively to the above described Ausführungsbei ^¬ play the plastic housing 7 is made directly from a graphenoxid--containing composite material in an alternative embodiment of the CT apparatus 2, that is, the Kunststoffge ^¬ housing 7 is not subsequently coated in this case with the graphical phenoxidhaltigen coating. For the production of the plastic housing 7, a synthetic resin with particulate graphene oxide is mixed as a filler and the plastic housing 7 or its individual parts, such as side walls and covers, made of composite material, for example, in the injection molding ^¬ method. The plastic housing 7 or its individual parts and the support cloth 6 are different embodiments of the medical device according to the invention. In another execution of the invention, approximately form the medical device is formed by a cover, a casing or a cover for one of the following components: a patient table, a wall stand, a control console at a Pati ^¬ ducks lie, a CT or MRI machine, a Switch, a human-machine interface, a button, a Bodenele ^¬ ment, a contrast agent device, a display or Moni ^¬ tor, a storage aid, a coil device for an MRI device, a wall paneling, a C-arm device , and its associated components (such as trolley, cable), an X-ray tube and its associated components (such as tripod, control console), a PET, SPECT, PETMR and their associated compo ^¬ nents, an input device (touchpad) for controlling a me ^¬ Medical device, an irradiation device of Strahlenthera ^¬ pie and afterloading (brachy therapy).

The subject matter of the invention is not limited to the ^exemplary embodiments described above. Rather, other embodiments of the invention may be derived by those skilled in the art from the foregoing description.

Claims

claims

1. Medical device (6, 7) with a potentially kon ^¬ taminierbaren surface (10, 15),

wherein to produce an autodisinfecting effect of the surface (10, 15),

the surface (10, 15) is provided with a coating (11, 16) consisting essentially of graphene oxide or a graphene oxide-containing composite material, or

is made a surface (10) of the complete component Medical Intern ^¬ rule device (7) consists of a graphene oxide comprising composite material.

2. Medical device (6, 7) according to claim 1,

wherein the graphene oxide is doped with silicon (Si) or silicon monoxide (SiO) to enhance its adhesion properties.

3. Medical device (6, 7) according to claim 1 or 2, which is formed as a cover, as a cover or as a coating of a medical device (2), wherein the medical device in particular

as a patient table (3) and / or an associated component,

as an imaging device, in particular an MRT or CT device (2), and / or an associated component, as a device of a medical room, as a wall, floor or ceiling panel of a medical room, and / or

is designed as an input, a display or a control device.

4. Medical device (6, 7) according to claim 1 or 2, which is designed as a medical instrument.

5. Medical device (6) according to claim 1 or 2, which is designed as a support cloth (6) for a patient bed (5).

6. Medical device (6) according to claim 5,

wherein the overlay cloth (6) comprises a first layer (20) of a hydrophobic and liquid-tight material which is connected in a planar manner to a second layer (21) of a liquid-absorbing material, and wherein the liquid-receiving layer (21) is provided with a Coating (16) containing graphene oxide is provided.

7. A method for producing a medical device (6, 7) according to one of claims 1 to 6,

wherein a potentially contaminable surface (10, 15) of the medical device (6, 7) is generated to produce an autodisinfecting effect.

a surface (10) of the complete component Medical Intern ^¬ rule device (7) consists of a graphene oxide comprising composite material is manufactured.

8. The method according to claim 7,

9. The method according to claim 7 or 8,

wherein the coating (11, 16) is applied to the surface (11, 16) by means of an aerosol printer (30, 40) or an ink jet printer.

10. The method according to claim 9,

wherein a first aerosol stream (Α ', Β') is produced from a matrix material (A, B), wherein a second aerosol stream (C) is produced from a graphene oxide-containing suspension (C), and

wherein the two aerosol streams (Α ', B'; C ') for generating ei ^¬ ner graphenoxidhaltigen coating (11, 16) together on the surface (10, 15) of the medical device (6, 7) are applied.

A graphene oxide-containing composite material for use in a medical device (6, 7) according to any one of claims 1 to 6,

wherein graphene oxide is embedded as a filler in a matrix, and

wherein the matrix is in particular a resin, preferably a synthetic resin, or a metal or an alloy.

12. Graphenoxidhaltiger composite material according to claim 11, wherein the graphene oxide is doped to enhance its adhesion properties with silicon (Si) or silicon monoxide (SiO).