WO2018013609A8 - Synthetic melanin nanoparticles and uses thereof - Google Patents

Synthetic melanin nanoparticles and uses thereof Download PDF

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Publication number
WO2018013609A8
WO2018013609A8 PCT/US2017/041596 US2017041596W WO2018013609A8 WO 2018013609 A8 WO2018013609 A8 WO 2018013609A8 US 2017041596 W US2017041596 W US 2017041596W WO 2018013609 A8 WO2018013609 A8 WO 2018013609A8
Authority
WO
WIPO (PCT)
Prior art keywords
synthetic melanin
melanin nanoparticles
nanoparticles
synthetic
melanin
Prior art date
Application number
PCT/US2017/041596
Other languages
French (fr)
Other versions
WO2018013609A2 (en
WO2018013609A3 (en
Inventor
Nathan C. Gianneschi
Yuran HUANG
Yiwen Li
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Priority to US16/317,003 priority Critical patent/US11045493B2/en
Publication of WO2018013609A2 publication Critical patent/WO2018013609A2/en
Publication of WO2018013609A3 publication Critical patent/WO2018013609A3/en
Publication of WO2018013609A8 publication Critical patent/WO2018013609A8/en
Priority to US17/332,704 priority patent/US20210393673A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles

Abstract

Provided, inter alia, are synthetic melanin nanoparticles (MelNPs) useful for protecting keratinocytes from UV-damage and for treating melanin-defective diseases.
PCT/US2017/041596 2016-07-11 2017-07-11 Synthetic melanin nanoparticles uses thereof WO2018013609A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US16/317,003 US11045493B2 (en) 2016-07-11 2017-07-11 Synthetic melanin nanoparticles and uses thereof
US17/332,704 US20210393673A1 (en) 2016-07-11 2021-05-27 Synthetic melanin nanoparticles and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662360821P 2016-07-11 2016-07-11
US62/360,821 2016-07-11

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US16/317,003 A-371-Of-International US11045493B2 (en) 2016-07-11 2017-07-11 Synthetic melanin nanoparticles and uses thereof
US17/332,704 Continuation US20210393673A1 (en) 2016-07-11 2021-05-27 Synthetic melanin nanoparticles and uses thereof

Publications (3)

Publication Number Publication Date
WO2018013609A2 WO2018013609A2 (en) 2018-01-18
WO2018013609A3 WO2018013609A3 (en) 2018-03-08
WO2018013609A8 true WO2018013609A8 (en) 2019-01-31

Family

ID=60953346

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2017/041596 WO2018013609A2 (en) 2016-07-11 2017-07-11 Synthetic melanin nanoparticles uses thereof

Country Status (2)

Country Link
US (2) US11045493B2 (en)
WO (1) WO2018013609A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11072681B2 (en) 2014-07-28 2021-07-27 The Regents Of The University Of California Compositions and methods of making polymerizing nucleic acids
ES2751200A1 (en) * 2018-09-28 2020-03-30 Consejo Superior Investigacion Precursor composition of a polydopamine pigment for the skin and its uses (Machine-translation by Google Translate, not legally binding)
US20220332670A1 (en) * 2019-06-28 2022-10-20 Northwestern University Artificial melanin nanoparticles and methods including porous melanin materials
WO2021096692A1 (en) * 2019-11-15 2021-05-20 Northwestern University Artificial melanin nanoparticles and precursor molecules as hair dyes
WO2022115145A1 (en) * 2020-11-25 2022-06-02 Ali Dhinojwala Stabilization of melanin-based supraparticles using polymeric glue
WO2022232356A1 (en) * 2021-04-28 2022-11-03 Northwestern University Melanin materials for tissue repair
CN115463129A (en) * 2021-06-11 2022-12-13 深圳先进技术研究院 Application of melanin or polydopamine nanoparticles as immune checkpoint Siglec-15 inhibitor in tumor resistance
CN114917192B (en) * 2022-04-22 2023-12-12 上海市第十人民医院 Modified polydopamine nanoparticle and application thereof in treatment of inflammation and cancer

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US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (en) 1985-10-03 1988-12-02 Merck Sharp & Dohme LIQUID-GEL PHASE TRANSITION PHARMACEUTICAL COMPOSITION
DE69212850T2 (en) 1991-01-15 1997-03-06 Alcon Lab Inc Use of carrageenan in topical ophthalmic compositions
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
US5441542A (en) 1991-09-26 1995-08-15 Clairol Incorporated Process and kit for post-oxidative treatment of permanently dyed hair
US5279618A (en) 1991-09-26 1994-01-18 Clairol Incorporated Process and kit for dyeing hair
FR2688136B1 (en) 1992-03-03 1995-06-09 Oreal COSMETIC COMPOSITION CONTAINING MELANIC PIGMENTS IN ASSOCIATION WITH CERTAIN TOCOPHEROLS, AND METHOD FOR PROTECTING THE SKIN, HAIR, MUCOSA AND COSMETIC COMPOSITIONS.
DE602005027463D1 (en) 2004-02-13 2011-05-26 Cognis France Sas USE OF A COSMETIC COMPOSITION CONTAINING EXTRACT OF CASTANEA SATIVA LEAVES
US8586090B2 (en) 2004-10-05 2013-11-19 Albert Einstein College Of Medicine Of Yeshiva University Melanin nanoshells for protection against radiation and electronic pulses
JP4955920B2 (en) 2004-12-08 2012-06-20 花王株式会社 Hair dye composition
KR101507188B1 (en) 2007-06-27 2015-03-30 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 Peptide tyrosinase inhibitors and uses thereof
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Also Published As

Publication number Publication date
US20200113934A1 (en) 2020-04-16
WO2018013609A2 (en) 2018-01-18
WO2018013609A3 (en) 2018-03-08
US11045493B2 (en) 2021-06-29
US20210393673A1 (en) 2021-12-23

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