WO2017178601A1 - Dispositif d'irradiation médicale - Google Patents

Dispositif d'irradiation médicale Download PDF

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Publication number
WO2017178601A1
WO2017178601A1 PCT/EP2017/058960 EP2017058960W WO2017178601A1 WO 2017178601 A1 WO2017178601 A1 WO 2017178601A1 EP 2017058960 W EP2017058960 W EP 2017058960W WO 2017178601 A1 WO2017178601 A1 WO 2017178601A1
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WO
WIPO (PCT)
Prior art keywords
light
luminescent material
comprised
led
oled
Prior art date
Application number
PCT/EP2017/058960
Other languages
English (en)
Inventor
Uwe Berlekamp
Sabine Otto
David ENSLING
Thomas JÜSTEL
Beata MALYSA
Original Assignee
Merz Pharma Gmbh & Co. Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Merz Pharma Gmbh & Co. Kgaa filed Critical Merz Pharma Gmbh & Co. Kgaa
Publication of WO2017178601A1 publication Critical patent/WO2017178601A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0616—Skin treatment other than tanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0653—Organic light emitting diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light
    • A61N2005/0663—Coloured light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0625—Warming the body, e.g. hyperthermia treatment

Definitions

  • the present invention relates to a medical irradiation device, in particular in the form of a medical patch, in which different types of emission spectra can be adjusted by exciting a luminescent material by means of an organic or inorganic light emitting diode such that the emitted light may be optimised for a predetermined application such as a therapeutic application.
  • the therapeutic application may optionally include a cosmetic and / or an aesthetic application or result in such application.
  • OLEDs organic light emitting diodes
  • LEDs inorganic light emitting diodes
  • light sources using LEDs for activating the formation of collagen are commercially available.
  • Patches comprising LEDs such as (ln,Ga)N LEDs emitting blue light for pain relief purposes are also commercially available.
  • EP 2 422 845 A1 relates to an apparatus for directing electromagnetic radiation into a respective pupil of at least one eye of a user.
  • the apparatus comprises first radiation emitting means comprising at least one radiation emitting layer adapted to emit electromagnetic radiation and second radiation emitting means adapted to direct electromagnetic radiation into at least one eye and/or onto at least one eyelid of a user.
  • a light guide is adapted to receive radiation emitted by the first radiation emitting means and to direct at least part of the radiation to the second radiation emitting means, wherein a total surface area of the first emitting radiation means from which radiation is emitted is larger than a total cross sectional area of a beam of radiation entering the or each pupil of the user in use, in a direction transverse to an optical axis of the beam.
  • US 2007/0170842 A1 relates to an illumination device with at least one LED as the light source, the LED emitting primary radiation in the range from 370 to 430 nm of the optical spectral region (peak wavelength), this radiation being partially or completely converted into radiation of a longer wavelength by three phosphors which are exposed to the primary radiation from the LED and which emit in the blue, green and red spectral regions, so that white light is formed.
  • the conversion is achieved at least with the aid of a phosphor which emits blue light with a wavelength maximum at 440 to 485 nm, and with the aid of a phosphor which emits green light with a wavelength maximum at 505 to 550 nm, and with the aid of a phosphor which emits yellow to red light with a wavelength maximum at 550 to 670 nm.
  • WO 201 1 /135502 A1 relates to a phototherapy patch for relieving nociceptive pain of a body part by illumination of at least part of the body part.
  • the patch is formed for conforming to at least part of the body part.
  • the patch comprises a first light source for emitting light.
  • the patch is arranged for illuminating at least a portion of the body part with light from the first light source.
  • the first light source is configured to emit light with a wavelength in the range of 430 nm to 475 run.
  • WO 2013/105007 A1 relates to a light emitting textile device comprising a first textile sheet comprising conductors and at least one light source connected to the conductors and being configured to emit first light at a first wavelength.
  • the device comprises a second textile sheet arranged over at least a portion of the first sheet and being configured to be illuminated by the first light.
  • the second sheet comprises a photoluminescent conversion material configured to convert incident first light at the first wavelength to emitted second light at a second wavelength, different from the first wavelength.
  • the device is configured to illuminate an object with at least a portion of at least the second light.
  • WO 2014/184038 A1 relates to an UV radiation device, comprising an LED comprising a nitride material which is arranged to emit first UV radiation in a wavelength range of 200 nm to 300 nm and a luminescent material doped with at least one of the following activators selected out of the group Eu 2+ , Ce 3+ , Pr 3+ , Nd 3+ , Gd 3+ , Tm 3+ , Sb 3+ , ⁇ , Pb 2+ and Bi 3+ , wherein the luminescent material is configured to convert at least a part of the primary UV radiation into secondary UV radiation, the primary UV radiation and the secondary UV radiation having a different spectral distribution.
  • a light-emitting layer comprises a luminescent compound that has a peak emission of about 620 nm to about 640 nm.
  • WO 20 0/004500 A1 relates to a cosmetic appliance. It has a housing and comprises a light source module arranged to emit light in a predefined first wavelength range through the use of one or more light sources, e.g. LEDs.
  • An optical module is arranged to deliver light emitted by the light source module to a user's body part to achieve a first cosmetic effect.
  • the cosmetic effect targeted may be tanning (using light in the range 400 to 440 nm), acne reduction (400 to 440 nm), or psoriasis reduction (300 to 360 nm).
  • the optical module comprises an adjustable color converting device arranged to convert light of the first wavelength range to light in a predefined second wavelength range to achieve a second cosmetic effect, for instance, skin rejuvenation (580 to 660 nm).
  • WO 201 1/1 17791 A1 relates to a LED-based lighting device comprising a plurality of luminescent materials, wherein the luminescent materials are excitable by light from the LED, and wherein the LED and the luminescent materials are arranged to emit light in the wavelength ranges 440 to 490 nm, 500 to 580 nm, 590 to 680 nm, 690 to 850 nm, 850 to 950 nm and 000 to 1200 nm.
  • Such LED-based lighting device may be used for indoor lighting, for medical treatment of mental diseases, and for mood lighting.
  • WO 2012/127389 A1 discloses a light guide material.
  • the light guide material comprises a carrier material provided with a photoiuminescent material.
  • the carrier material is arranged for receiving and transmitting first light from a light source having a first wavelength.
  • the photoiuminescent material is arranged for converting at least a portion of said received first light into second light having a second wavelength, different from the first wavelength.
  • At least a portion of the carrier material is a silicone material and at least a portion of the photoiuminescent material is an organic photoiuminescent material.
  • US 2013/304162 A1 discloses an apparatus for directing electromagnetic radiation into a respective pupil of at least one eye of a user.
  • the apparatus comprises first radiation emitting means comprising at least one radiation emitting layer adapted to emit electromagnetic radiation and second radiation emitting means adapted to direct electromagnetic radiation into at least one eye and/or onto at least one eyelid of a user.
  • a light guide is adapted to receive radiation emitted by the first radiation emitting means and to direct at least part of the radiation to the second radiation emitting means, wherein a total surface area of the first emitting radiation means from which radiation is emitted is larger than a total cross sectional area of a beam of radiation entering the or each pupil of the user in use, in a direction transverse to an optical axis of the beam.
  • US 2013/344454 A1 discloses an appliance for dermatological or cosmetic treatment of a patient which comprises a base body, which has a radiation source for emitting light in a wavelength range between 350 nm and 1000 nm.
  • An intermediate piece sitting on the base body conveys the light from the radiation source in the direction of a body region of the patient to be treated.
  • US 2012/182758 A1 discloses the optical transmission of a light guide assembly in an optical illumination apparatus achieved by one or more insulation layers which sheath a rigid or flexible light guide rod of the light guide assembly and/or the coupling of light emitted from a radiation source into the light input surface of the light guide rod by an adapter element.
  • US 2012/289885 A1 discloses a phototherapy system for treating a treatment region having a treatment surface.
  • the phototherapy system comprises an optical device.
  • the optical device includes a light source generating source light, an emission surface emitting emitted light, and a sheet waveguide.
  • the light source is coupled to direct the source light into the sheet waveguide.
  • the sheet waveguide has a plurality of light extraction features that direct light out of the sheet waveguide.
  • the phototherapy system may further comprise a treatment patch and a photoactive compound within the treatment region.
  • US 201 1/275978 A1 discloses dressings, such as patches and bandages, and other devices and systems that deliver nitric oxide.
  • An illumination assembly can include at least one solid state light- emitting device, and at least one light guide including a light homogenization region configured to receive light emitted by the solid state light-emitting device and including a light output boundary.
  • the light homogenization region substantially uniformly distributes light outputted over the light output boundary.
  • a wavelength converting material can be disposed within at least a portion of the light homogenization region.
  • US 2013/296976 A1 discloses a light converting device for receiving source light within a source wavelength range, converting the source light into an interim light, and converting the interim light into a converted light.
  • the lighting device may include an enclosure with an application of a wide production conversion coating and a narrow production conversion coating to perform a series of wavelength conversion operations on a source light to produce a converted light.
  • WO 2010/150202 A2 discloses an illumination apparatus which includes a substantially planar waveguide, a plurality of light sources embedded within the in- coupling region of the waveguide, and a film disposed over the out-coupling region of the waveguide.
  • the film has a thickness less than approximately 100 ⁇ and comprises or consists essentially of a photoluminescent material.
  • the photoluminescent material converts a portion of light emitted by at least one of the light sources to a different wavelength.
  • EP 2 383 017 A1 discloses a phototherapy patch for relieving nociceptive pain of a body part by illumination of at least part of the body part.
  • the patch is formed for conforming to at least part of the body part.
  • the patch comprises a first light source for emitting light.
  • the patch is arranged for illuminating at least a portion of the body part with light from the first light source.
  • the first light source is configured to emit light with a wavelength in the range of 430 nm to 475 nm.
  • US 4 907 132 A discloses light emitting panel assemblies and method of making same, and which include one or more layers of woven fiber optic material having disruptions or bends at discrete locations along the length of the fibers to allow light to be emitted therefrom. Only selected areas of the disruptions or bends are coated with a suitable coating material that has a refractive index that changes the attenuation of the light emitted from the selected areas.
  • One object of the present invention is the provision of an irradiation device, which may be used in a therapeutic, cosmetic and / or aesthetic application such that the emitted light may be specifically adjusted in a tailor-made manner to the intended use.
  • an irradiation device in particular in the form of a medical patch, comprising first means comprising at least one OLED or LED which is configured to emit light, and a second means comprising at least one luminescent material which is configured to emit light by converting said light emitted from said at least one OLED or LED to a longer wavelength range.
  • first means comprising at least one OLED or LED which is configured to emit light
  • second means comprising at least one luminescent material which is configured to emit light by converting said light emitted from said at least one OLED or LED to a longer wavelength range.
  • at least one luminescent material emits said light when being excited by the emitted light from said at least one OLED or LED.
  • the first means and the second means are connected by third means, which comprises an optical waveguide.
  • Said waveguide comprised in the third means is beneficial for decoupling the heat emitted from said OLED or LED from the luminescent material. This allows that e.g. only a light therapy or phototherapy, optionally including a cosmetic and /or aesthetic application, may be performed without applying heat.
  • the first means and the second means are connected to one another by means of a waveguide which may be detachable from said first means and / or said second means. This is of particular advantage since - depending on the intended use - via the detachable optical waveguide a specific second means may be substituted by another specific second means while keeping the same excitation source.
  • the invention relates to the following items 1 to 19:
  • Medical patch comprising: a light entry portion (X);
  • a light emitting portion Z
  • first means A
  • second means B
  • third means C
  • the light entry portion (X) being configured to receive light from said third means (C) comprising an optical waveguide
  • the light converting portion (Y) comprising said second means (B) comprising at least one luminescent material being configured to emit light by converting light emitted from said first means (A) comprising at least one OLED or LED;
  • the light emitting portion (Z) being configured to contact and irradiate a skin, a tissue or a muscle, or a combination of two or three thereof; wherein said third means (C) comprising said optical waveguide receives light from said first means (A) comprising at least one OLED or LED being configured to emit said light; said third means (C) comprising said optical waveguide is configured to guide said light emitted by said at least one OLED or LED comprised in said first means
  • said third means (C) connects said first means (A) to said second means (B); and wherein said optical waveguide comprised in said third means (C) is configured to be detachable from said first means (A) or from said second means (B) or from said first means (A) and said second means (B).
  • Medical patch according to item 1 wherein said first means (A) and said second means (B) are not in physical contact with one another.
  • said third means (C) receives the light from said first means (A) and emits the light in a first light direction
  • the second means (B) is configured to emit light in a second light direction, which differs from the first light direction by an angle a, preferably by 0° ⁇ a ⁇ 90°.
  • said at least one LED comprised in the first means (A) comprises (ln,Ga)N or (AI,ln,Ga)N and is configured to emit light in the wavelength range of from 370 to 480 nm; wherein said at least one luminescent material comprised in the second means (B) comprises an inorganic compound selected from the group comprising or consisting of:
  • said at least one luminescent material comprised in the second means (B) comprises a luminescent organic compound or a quantum dot-comprising material; preferably selected from the group comprising or consisting of: a perylene dye, a triphenylene dye, a naphthalimide dye, a xanthene dye, a phenoxazine dye, an acridine dye, an anthracene dye, a phenazine dye, or a coumarin dye
  • said second means (B) comprises cover means (G), wherein the second means (B) has a light emitting surface, and the cover means (G) prevents light being emitted from other surfaces of the second means (B) than said light emitting surface.
  • said optical waveguide comprised in the third means (C) is in the form of a fiber.
  • said at least one optical element (F) comprises or consists of a light distributing structure that distributes the light emitted from said at least one first means (A).
  • Medical patch according to item 10 or 1 1 wherein said at least one optical element (F) comprises or consists of a reflector device, wherein said reflector device is arranged such to at least partially enclose an area of said second means (B) comprising said at least one luminescent material.
  • Medical patch comprising at least one of the following for detachably connecting said waveguide comprised in the third means (C) to said first means (A) or to said a second means (B) or to the first means (A) and the second means (B): a connector system comprising a plug and a socket; a receiving portion for receiving an end portion of said waveguide, wherein said receiving portion comprises a cavity configured to contain an optical gel, and preferably containing said optical gel; and/or a cleavable fusion splice.
  • Medical irradiation device comprising: first means (A) comprising at least one OLED or LED configured to emit light; second means (B) comprising at least one luminescent material configured to emit light by converting said light emitted from said at least one OLED or LED
  • third means (C) comprising an optical waveguide configured to guide said light emitted by said at least one OLED or LED comprised in said first means (A) to said at least one luminescent material comprised in said second means (B); wherein said third means (C) connects the first means (A) to the second means
  • said third means (C) connects the first means (A) to the second means (B); and wherein said optical waveguide comprised in said third means (C) is configured to be detachable from the first means (A) or from the second means (B) or from the first means (A) and the second means (B).
  • Luminescent material for use in a therapeutic application wherein the therapeutic application comprises or consists of the irradiation of a skin, a tissue or a muscle, or a combination of two or three thereof, of a subject, the luminescent material being comprised in a medical patch as defined in item 1 or in a medical device as defined in item 14, wherein said light emitted by said at least one luminescent material comprised in said second means (B) is used for said irradiation of a skin, a tissue or a muscle, or a combination of two or three thereof, of said subject.
  • Luminescent material for use according to any one of items 15 to 16 wherein said therapeutic application comprises a cosmetic application or aesthetic application or a cosmetic and an aesthetic application.
  • Method of performing a therapeutic treatment or a cosmetic treatment or an aesthetic treatment or a combination of two or more thereof of a subject comprising: directing light emitted from said second means (B) of the medical patch as defined in any one of items 1 to 13 onto the subject, wherein said medical patch contacts said subject.
  • Method of performing a therapeutic treatment or a cosmetic treatment or an aesthetic treatment or a combination of two or more thereof of a subject comprising: directing light emitted from said second means (B) of the medical irradiation device as defined in item 14 onto the subject.
  • said therapeutic application is selected from the group consisting of: light therapy, photodynamic therapy, or heat therapy, or a combination of two or three thereof.
  • said irradiation is a therapy of stressed muscles, relaxation of muscles, improvement of perfusion, reduction of viscosity of synovial fluid, improvement of collagen formation, treatment of DNA damages, reduction of inflammatory skin reactions, treatment of atopic dermatitis, and/or treatment of pruritus.
  • said method comprises a cosmetic and / or aesthetic application.
  • said cosmetic and / or aesthetic application is selected from the group consisting of: removal of macula, removal of tattoos, removal of hairs (epilation), reduction of wrinkles, or reduction of scar tissue, treatment of hair loss, treatment or amelioration of cellulite, non-invasive treatment to improve aesthetic impression of under-chin, neck and decolletage.
  • said method is a cosmetic and / or aesthetic application.
  • said cosmetic and / or aesthetic application is selected from the group consisting of: removal of macula, removal of tattoos, removal of hairs (epilation), reduction of wrinkles, or reduction of scar tissue, treatment of hair loss, treatment or amelioration of cellulite, non-invasive treatment to improve aesthetic impression of under-chin, neck and decolletage.
  • Fig. 1 shows an exemplary irradiation device suitable for use in a therapeutic application such as the irradiation of a skin, a tissue or a muscle, or a combination of two or three thereof, of a subject.
  • Fig. 2 shows another exemplary irradiation device suitable for use in a therapeutic application such as the irradiation of a skin, a tissue or a muscle, or a combination of two or three thereof, of a subject.
  • the invention relates to a medical patch.
  • the term "patch" in its broadest meaning encompasses any means that can be attached to a certain part of the skin of a human, or can be located close to a certain part of the skin of a human.
  • said means may be an article of manufacture having a length, a depth and a width by means of which a certain part of the skin of a human can be covered.
  • said luminescent material is comprised in said patch.
  • the invention relates to a medical patch, comprising: a light entry portion (X);
  • Y comprising second means (B) comprising at least one luminescent material configured to emit light by converting light emitted from at least one OLED or
  • (Z) being configured to contact and irradiate a skin, a tissue or a muscle, or a combination of two or three thereof.
  • said third means (C) comprising an optical waveguide receives light from said first means (A) comprising at least one OLED or LED configured to emit said light.
  • said light converting portion (Y) comprises second means (B) comprising at least one luminescent material configured to emit light by converting said light emitted from said at least one OLED or LED (A).
  • said third means (C) comprising said optical waveguide is configured to guide said light emitted by said at least one OLED or LED comprised in said first means (A) to said at least one luminescent material comprised in said second means (B).
  • said third means (C) connects the first means (A) to the second means (B).
  • Second aspect Medical irradiation device
  • the invention further relates to an irradiation device comprising: first means (A) comprising at least one OLED or LED configured to emit light; second means (B) comprising at least one luminescent material configured to emit light by converting said light emitted from said at least one OLED or LED (A); wherein said luminescent material is a luminescent organic compound or a quantum dot- comprising material; third means (C) comprising an optical waveguide configured to guide said light emitted by said at least one OLED or LED comprised in said first means (A) to said at least one luminescent material comprised in said second means (B); wherein said third means (C) connects the first means (A) to the second means (B).
  • said irradiation device is a medical irradiation device. Accordingly, said irradiation device is used in a medical application.
  • Luminescent material for use [0047] The invention further relates to a luminescent material for use in the irradiation of a skin, a tissue or a muscle, or a combination of two or three thereof, of a subject, the luminescent material being comprised in an irradiation device, the irradiation device comprising: first means (A) comprising at least one OLED or LED configured to emit light; second means (B) comprising at least one luminescent material configured to emit light by converting said light emitted from said at least one OLED or LED (A); third means (C) comprising an optical waveguide configured to guide said light emitted by said at least one OLED or LED comprised in said first means (A) to said at least one luminescent material comprised in said second means (B); wherein said third means (C) connects the first means (A) to the second means (B); and
  • said light emitted by said at least one luminescent material comprised in said second means (B) is used for said irradiation of a skin, a tissue or a muscle, or a combination of two or three thereof, of said subject.
  • first means (A) comprising at least one OLED or LED configured or adapted to emit light
  • second means (B) comprising at least one luminescent material configured to emit light by converting said light emitted from said at least one OLED or LED (A)
  • third means (C) comprising an optical waveguide configured to guide said light emitted by said at least one OLED or LED comprised in said first means (A) to said at least one luminescent material comprised in said second means (B).
  • said first means (A) and said second means (B) are not in physical contact with one another, i.e. said first and said second means are physical separated from one another.
  • At least a part of said second means (B) is configured to be attachable to a subject or to the skin of a subject. Attaching may be effected by means of suitable attaching means such as a tape.
  • said second means (B) is configured to emit light wherein the third means (C) receives the light from the first means (A) and emits the light in a first light direction, wherein the second means (B) is configured to emit light in a second light direction, which differs from the first light direction, preferably in an angle of from 0° to 90° or more than 0° and equal or less than 90°.
  • light direction of emitted light is understood to be the direction of the geometrical centre of the direction of the maximum light intensity in case of a non-parallel light beam.
  • OLED encompasses a light emitting diode based on an organic material.
  • LED encompasses a light emitting diode based on an inorganic semiconductor chip.
  • light' is synonymously used with the term “radiation” or “optical radiation”.
  • optical radiation covers a wavelength range of from 100 nm to 1 mm.
  • At least one OLED or LED encompasses an OLED- or LED-array.
  • the term "OLED- or LED-array” encompasses an arrangement of more than one OLED or LED. In one embodiment, said OLEDs or LEDs are arranged in the array in rows or columns or rows and columns.
  • the light emitting diode is based on an inorganic material.
  • said LED is represented by the general formula MZ, wherein M represents at least two of Al, In, or Ga, and Z represents N or P.
  • said irradiation device comprises: first means (A) comprising at least one LED based on a compound of the general formula MZ, wherein M represents at least two of Al, In, or Ga, and Z represents N or
  • second means (B) comprising at least one luminescent material which is configured to emit light in a wavelength range of from 400 to 4,000 nm by converting said light emitted from said at least one LED (A).
  • said LED comprised in the first means (A) comprises at least two of the elements selected from Al, In, and Ga in combination with N.
  • said LED comprised in the first means (A) comprises (ln,Ga)N or (AI,ln,Ga)N.
  • LEDs comprised in the first means (A) based on (ln,Ga)N or (AI,ln,Ga)N are known. Such LEDs may emit blue light in the wavelength range of from 370 to 480 nm.
  • said LED comprised in the first means (A) comprises at least two of the elements selected from Al, In and Ga in combination with P.
  • said LED comprised in the first means (A) comprises (ln,Ga)P or (AI,ln,Ga)P.
  • LEDs comprised in the first means (A) based on (ln,Ga)P or (AI,ln,Ga)P are known. Such LEDs may emit light in the range of from 550 to 800 nm.
  • said medical patch or irradiation device comprises: first means (A) comprising at least one LED based on (ln,Ga)P or (AI,ln,Ga)P configured to emit light in the wavelength range of from 550 to 800 nm; second means (B) comprising at least one luminescent material configured to emit light in a wavelength range of from 600 to 4,000 nm by converting said light emitted from said at least one LED comprised in the first means (A).
  • said irradiation device comprises first means (A) comprising at least one LED based on (ln,Ga)N or (AI,ln,Ga)N or (ln,Ga)P or (AI,ln,Ga)P; second means (B) comprising at least one luminescent material configured to emit light in a wavelength range of from 400 to 4,000 nm by converting said light emitted from said at least one LED comprised in the first means (A).
  • said medical patch or (medical) irradiation device comprises: first means (A) comprising at least one LED based on (in,Ga)N or (AI,ln,Ga)N configured to emit light in the wavelength range of from 370 to 480 nm; second means (B) comprising at least one luminescent material configured to emit light in a wavelength range of from 400 to 4,000 nm by converting said light emitted from said at least one LED (A).
  • said medical patch or (medical) irradiation device comprises: first means (A) comprising at least one LED based on (ln,Ga)P or (AI,ln,Ga)P configured to emit light in the wavelength range of from 550 to 800 nm; second means (B) comprising at least one luminescent material configured to emit light in a wavelength range of from 600 to 4,000 nm by converting said light emitted from said at least one LED comprised in the first means (A).
  • luminescent materia!' relates to any material that is suitable to convert the light emitted by said OLED or LED comprised in the first means (A).
  • luminescent materiaT further encompasses the terms "luminescent substance” and "luminescent composition” .
  • luminescent materia!' is also synonymously used with the term “photocon version materia!', and also encompasses terms such as "fluorescent matena!' or "phosphorescent materia!' or "luminescent converter”. [0078] The term “luminescent materia!' comprises the terms “luminescent substance” or "luminescent compound'.
  • said luminescent material comprised in the second means (B) converts said light to a light having a longer wavelength than the exciting light emitted from the at least one OLED or LED comprised in the first means (A).
  • the luminescent material comprised in the second means (B) converts said emitted light to cyan or green or yellow or amber or red light or light in the NIR region (Near Infrared).
  • said luminescent material comprised in the second means (B) is selected from one or more of compounds emitting light in the color cyan.
  • said luminescent material comprised in second means (B) is selected from one or more of the inorganic compounds listed in Table 1 :
  • the luminescent material comprised in second (B) is selected from one or more compounds emitting light in the color green.
  • said luminescent material comprised in said second means (B) is selected from one or more of the compounds listed in Table 2:
  • the luminescent material comprised in said second means (B) is selected from one or more compounds emitting light in the color yellow.
  • said luminescent material comprised in said second means (B) is selected from one or more of the compounds listed in Table 3:
  • the luminescent material comprised in said second means (B) is selected from one or more compounds emitting light in the color amber.
  • said luminescent material comprised in said second means (B) is selected from one or more of the compounds listed in Table 4:
  • the luminescent material comprised in said second means (B) is selected from one or more compounds emitting light in the color red.
  • said luminescent material comprised in said second means (B) is selected from one or more of the compounds listed in Table 5:
  • the luminescent material comprised in said second means (B) is selected from one or more compounds emitting light in the NIR range.
  • said luminescent material comprised in said second means (B) is selected from one or more of the compounds listed in Table 6:
  • said luminescent material comprised in said second means (B) is selected from the group comprising or consisting of:
  • said luminescent material may be an organic compound, i.e. a luminescent organic dye, or a material comprising a luminescent organic dye, or a quantum dot or a quantum dot-comprising material.
  • Exemplary dyes include the daylight fluorescent-type dyes that belong to the dye families known as rhodamines, fluoresceins, coumarins, naphthalimides, xanthenes including benzoxanthenes, oxazines such as phenoxazines, oxazole such as benzoxazoles, perylenes, pyrenes, acridines, anthracenes, triphenylenes, phthalocyanines, porphyrines, stilbenes, carbocyanines, quinolones, thiazoles such as benzothiazoles, furans, metal complexes of said dyes such as Pt or Ir complexes, or a combination comprising at least two or more thereof.
  • rhodamines fluoresceins, coumarins, naphthalimides
  • xanthenes including benzoxanthenes
  • oxazines such as phenoxazines
  • oxazole such
  • suitable luminescent organic dyes may be selected from the group comprising or consisting of the following dyes: a perylene dye, a triphenylene dye, a naphthalimide dye, a xanthene dye, a phenoxazine dye, an acridine dye, an anthracene dye, a phenazine dye, or a coumarin dye, or two or more thereof.
  • perylene dye etc. means that the dye comprises a perylene moiety.
  • Examples include luminescent dyes such as 7-amino-4-methylcoumarin; 3- (2'-benzothiazolyI)-7-diethylaminocoumarin; 2-(4-biphenylyl)-5-(4-t-butylphenyl)- 1 ,3,4-oxadiazole; 2,5-bis-(4-biphenylyl)-oxazole; 2,2'-dimethyl-p-quaterphenyl; 2,2- dimethyl-p-terphenyl; 3,5,3"", 5""-tetra-t-butyl-p-quinquephenyl; 2,5-diphenylfuran; 2,5-diphenyloxazole; 4,4'-diphenylstilbene; 4-dicyanomethylene-2-methyl-6-(p- dimethylaminostyryl)-4H-pyran; 1 ,1 '-diethyl-2,2'-carbocyanine iodide; 3,3'-diethyl
  • Suitable fluorescent dyes include those available under the following tradenames: Diaresin® dyes from Mitsubishi Chemical (Japan); Lumogen® dyes from BASF (Germany), I rg a lite® and Maxilon® dyes from Ciba Specialty Chemicals (Germany), Macrolex® dyes from Lanxess (Germany), and Hostasol® dyes from Clariant.
  • Typical commercially available fluorescent dyes of the above types include amino phthalate dyes such as Rhodamine BDC (C.I. 45,170), Rhodamine 6GDN extra (C.I.
  • Rhodamine F5G Red 482
  • Rhodamine FB Rhodamine FB
  • Rhodamine F3B Rhodamine F3B
  • naphthalimide derivatives such as Lumogen® F Blue 650
  • perylene derivatives such as Lumogen® F Red 300; Lumogen® F Red 305; Lumogen® F Yellow 083; Lumogen® F Violet 570; Lumogen® F Green 850; Macrolex® Fluorescent Yellow 10GN (C.I.
  • Solvent Yellow 160: 1 Macrolex® Red G; Irgalite® Violet M, Maxilon® Brilliant Flavine 10GFF, Maxilon® Black FBL-01 , Maxilon® Black RM-01 , Maxilon® Blue 5G, Maxilon® Blue 5G-01 , Maxilon® Blue GRL/Pearl, Maxilon® Blue GRL Granulated, Maxilon® Blue GRL E, Maxilon® Blue M-G, Maxilon® Blue TRL Liquid, Maxilon® Golden Yellow GL Pearls, Maxilon® Navy FRL- 02, Maxilon® Red GRL-01 Pearl, Maxilon® Red GRL-E, Maxilon® Red GRL Pearls, Maxilon® Red M-4GL, Maxilon® Yellow M-3RL, and Maxilon® Yellow M-4GL; Hostasol® Red 5B (Vat Red 41 ), Hostasol® Red GG (Solvent Orange 63), and Hostasol® Yellow 3G (Solvent Yellow 98); Fluorescent yellow F6
  • fluorescent dyes useful herein include Lumogen® F Blue 650, Lumogen® Red 305, and Macrolex® Fluorescent Yellow 10GN. It will be understood that numerous fluorescent dyes are available commercially and are useful herein, and that therefore the foregoing list of fluorescent dyes should be considered exemplary and not limiting to the dyes disclosed hereinabove.
  • said luminescent material i.e. that luminescent organic dye or said quantum dot comprised in the second means (B) converts said light to a light having a longer wavelength than the exciting light emitted from the at least one OLED or LED comprised in the first means (A).
  • the luminescent material comprised in the second means (B) converts said emitted light to violet, green or yellow or amber or rose or red light or light in the NIR region (Near Infrared).
  • Rhodamine B red 573 (xanthene dye)
  • Lumogen® F Red 305 red 615 perylene dye; CAS No.
  • a targeted colour light may be generated and which is adjusted such to be suitable for the intended use.
  • the colour may be further adjusted by using a suitable filter or suitable filters.
  • the use of one or more color filters is not necessary. This is advantageous in view of the achievable efficiency of the emitted light.
  • Said luminescent material comprised in said second means (B) is comprised in an organic material.
  • said organic material is a solid polymeric material in which the luminescent material (B) is incorporated.
  • Suitable polymers may be silicone or epoxy resins, acrylates such as poly(methylmethacrylates) (PMMA), polycarbonate (PC) or polystyrenes (PS).
  • said luminescent organic dye is not dissolvable in said solid polymeric material but is rather dispersed therein.
  • said luminescent organic material incorporated in said polymeric material is provided in the form of nanobeads.
  • the particle size of the nanobeads in terms of D 90 is in the range of from 2 to 200 nm, the particle size being measured using light diffraction.
  • the same materials may be used as used for the optical waveguide comprised in the third means (C) as set out in the respective section below.
  • said organic material may be a semisolid polymeric material such as a gel in which the luminescent material comprised in the second means (B) is incorporated.
  • suitable gels are selected out of acrylates, cellulose ethers, xanthan, and carbomers, or mixtures of two or more thereof.
  • the refractive index of the polymeric material e.g. in the form of a gel, ranges from 1 .0 - 1 .5, and the refractive index of the luminescent material ranges from 1.5 - 2.5, preferably 1 .5 - 1.8.
  • said second means (B) is configured to be adapted to a certain shape of a target of a subject to be irradiated, e.g. a portion of the arm or leg or shoulder of a subject.
  • said second means (B) may also include the light emitting portion (Z).
  • the used luminescent material comprised in the second means (B) may be used in a coated form or an uncoated form.
  • coated' encompasses the term "encapsulated' . Suitable coating or encapsulating processes are known in the art.
  • a coating may increase the durability of the luminescent material comprised in the second means (B) or the stability of the emitted light thereof.
  • the concentration of the luminescent material comprised in the second means (B), at the place, where said light emitted by said at least one OLED or LED comprised in said first means (A), is guided via said optical waveguide comprised in said third means (C) to said at least one luminescent material comprised in said second means (B), is lower than in a place adjacent thereto.
  • the luminescent material comprised in said second means (B) is distributed such to form one or more concentration gradients.
  • said at least one luminescent material comprised in the second means (B) comprises at least one optical element (F) which is configured to increase the efficiency of the light output of said at least one luminescent material comprised in the second means (B) when said at least one luminescent material converts light emitted from said at least one OLED or LED comprised in the first means (A).
  • said at least one optical element (F) which is configured to increase the efficiency of the light output of said at least one luminescent material when said at least one luminescent material converts light emitted from said at least one OLED or LED, is selected from the group comprising or consisting of: lens, microlens, reflector, metal film, metallic nanoparticles, glass, or acrylic glass such as an acrylic glass, or a combination of two or more thereof.
  • said at least one optical element (F) which is configured to increase the efficiency of the light output of said at least one luminescent material, comprises or consists of a light distributing structure that distributes the light emitted by and received from said first means (A) comprising at least one OLED or LED across an area of the second means (B) comprising said at least one luminescent material.
  • said area covers at least half of the full area of the portion of the second means (B) comprising said at least one luminescent material. More preferably, said area covers at least 80 % of said full area.
  • said at least one luminescent material in the second means (B) may be excited with a specific pattern as desired by the skilled person.
  • the light received from said first means (A) comprising at least one OLED or LED may be distributed homogeneously over a portion of the second means (B), which comprises said at least one luminescent to material.
  • the light received from said first means (A) comprising at least one OLED or LED may be distributed with a pattern, particularly a light intensity pattern, which is at least essentially equal to that density distribution of said at least one luminescent material.
  • a light distribution matching the distribution of said at least one luminescent material may arise from the fact, that over-excitation and/or under-excitation of said at least one luminescent material may be reduced, thereby increasing the efficiency of the light output of said at least one luminescent material.
  • said light distributing structure may comprise or consist of one or more optical waveguides, in particular in the form of optical fibers.
  • one or more of the optical fibers of said light distributing structure are bent such that a portion of the light guided through said optical fibers escapes through the sidewalls of said optical fibers at the bends.
  • such an optical fiber of said light distributing structure comprises a side glow fiber and/or a portion that is configured to allow a portion of the light guided through said fiber to escape through the sidewalls of said fiber, even when this fiber is not bent.
  • an optical fibers allowing a portion of the guided light to escape through the sidewalls comprises one end for receiving the light emitted by said first means (A) comprising at least one OLED or LED.
  • this optical fiber is preferably configured, to have an increasing relative amount of light escaping through the sidewalls, the further the light has travelled through this fiber from said and for receiving the light emitted by said at least one OLED or LED.
  • the absolute amount of light escaping through a section of the sidewalls may at least essentially be constant, because the further the light travels through said fiber the more it is attenuated, e.g. by absorption and/or a portion of the light escaping through the sidewalls, and therefore a higher relative amount has to escape through the sidewalls to result in an at least essentially constant amount of slide escaping through the sidewalls along said fiber.
  • said light distributing structure may comprise at least one optical fiber.
  • Said optical fiber comprises one end portion for receiving the light emitted by said at least one OLED or LED comprised in the first means (A).
  • said optical fiber meanders across an area of the second means (B) comprising said at least one luminescent material.
  • the radii of the bends of the meander decrease the further the respective bend is distant from said end portion for receiving the light, wherein the distance between the respective bend and said end portion for receiving the light is a respective to the traveling distance the light guided through said optical fiber.
  • said at least one optical element (F), which is configured to increase the efficiency of the light output of said at least one luminescent material comprises or consists of a reflector device.
  • Said reflector device is arranged to at least partially enclose an area of the second means (B) comprising said at least one luminescent material.
  • said reflector device is arranged and/or configured to permit light being emitted through said light emitting surface of the second means (B) and to prevent light being emitted from at least one other surface of the second means (B) by reflecting the light. In this beneficial way, the efficiency of the light output may be increased.
  • said reflector device comprises a first and/or a second reflector surface each facing a side of said area of the second means (B) comprising said at least one luminescent material.
  • said first and second reflector surface are opposite to each other, wherein at least a portion of said area comprising said at least one luminescent material is arranged in between said first and second reflector surface.
  • said first and/or said second reflector surface are reflective for light with wavelengths which said at least one OLED or LED comprised in the first means (A) emits.
  • said first reflector surface is opaque for light with wavelengths which said at least one luminescent material emits.
  • said first reflector surface is arranged at said light emitting surface of the second means (B), in particular such that light emitted by said at least one luminescent material may pass through said first reflector surface and thus said light emitting surface, while light emitted by said at least one OLED or LED is reflected back to said at least one luminescent material.
  • said second means (B) comprises cover means (G), wherein said second means (B) has a light emitting surface, and the cover means (G) prevents light being emitted from other surfaces of the second means (B) than said light emitting surface.
  • Such means may be construed in the form of reflectors or other materials such as textile tissue, which at least partially cover the second means.
  • Such means cover at least a part of said second means (B) such to force light to be emitted from the light emitting portion (Z) of the medical patch.
  • the irradiation device comprises an optical waveguide which is comprised in said third means (C), and which is configured to guide said light emitted by said at least one OLED or LED comprised in the first means (A) to said at least one luminescent material comprised in the second means
  • optical waveguide which is synonymously used with the terms “waveguide” or “lightguide”, encompasses any physical structure that guides electromagnetic waves in the optical spectrum.
  • optical waveguides include optical fiber and rectangular waveguides.
  • the optical waveguide comprised in said third means (C) can be in the form of a planar, strip, or fiber waveguide.
  • said optical waveguide comprised in said third means comprises
  • (C) is a two-dimensional waveguide such as a strip waveguide or a rib waveguide as is known in the field of optical waveguides.
  • said waveguide comprised in said third means (C) is an optical fiber as is known in the art.
  • waveguide and the term “optical fiber” encompass a circular cross-section dielectric waveguide consisting of a dielectric material surrounded by another dielectric material with a lower refractive index. Accordingly, light being guided in said waveguide or optical fiber is subjected to a total internal reflection within the waveguide or optical fiber.
  • a waveguide is distinct e.g. from a layer of e.g. a polymeric material which allows light to transmit said polymeric material.
  • said optical fiber is made from silica glass or plastic optical fiber.
  • said plastic optical fiber is made from a poly(meth)acrylate or a polystyrene as the core material, and fluorinated polymers or silicone are the cladding material.
  • fluorinated polymers or silicone are the cladding material.
  • Other materials such as perfluorinated polymers such as poly(perfluoro butenyl vinyl ether) may be used, too.
  • Poly(methylmethacrylate) (PMMA) or polystyrene may be used as fiber core.
  • said optical fiber comprises or consists of a large core optical fiber.
  • a benefit of such a large core optical fiber in the application of the present invention may arise from the fact, that large core optical fibers typically can transfer a higher amount of light energy and/or intensity.
  • Another benefit may be that coupling large core fibers to each other or to a light source or a light sink typically is technicality easier and less error-prone than coupling with optical fibers with smaller cores, e.g. single mode fibers.
  • said optical fiber comprises or consists of a hollow optical fiber.
  • a benefit from said hollow optical fiber may arise from the fact that the interior of such fiber can be filled with a suitable gas, thereby further improving the transmission of light with relative short wavelength such as UV light.
  • Hollow optical fibers are known in the art.
  • said optical fiber comprises or consists of a photonic- crystal fiber.
  • the use of photonic-crystal fiber may improve the transmission of light with relative short wavelength emitted by said OLED or LED comprised in said first means (A).
  • Photonic-crystal fibers are known in the art.
  • said optical fiber comprises or consists of a hollow photonic-crystal fiber further improving light transmission.
  • Hollow photonic-crystal fibers are known in the art.
  • Hollow optical fibers, photonic-crystal fibers and hollow photonic-crystal fibers may be useful for increasing light output compared to waveguides having a core.
  • said optical fiber is a broadband optical fiber, which permits the transmission of light of a broad spectrum of wavelengths, e.g. light with wavelengths ranging from 200 nm to 2,000 nm or a sub range such as 400 nm to 800 nm.
  • said optical fiber is tuned to permit particularly the transmission of light with wavelengths that is emitted by said at least one OLED or LED comprised in the first means (A).
  • said optical fiber additionally functions as a filter, which filters out light with other wavelengths.
  • light with undesired wavelengths e.g. in particular infrared light or UV light, which does not excite said at least one luminescent material and/or is detrimental for a treated person, may be filtered out.
  • said waveguide comprised in said third means (C) has a planar structure, wherein said luminescent material comprised in said second means
  • At least a part of said optical waveguide comprised in said third means (C) has a planar structure and said at least one luminescent material comprised in said second means (B) is arranged on said planar structure, and at least a further part of said optical waveguide comprised in said third means
  • (C) is in the form of a fiber and connects the at least one OLED or LED (A) to said planar structure.
  • only said planar structure and said at least one luminescent material comprised in said second means (B) are in contact with skin or close to the skin, and the at least one OLED or LED comprised in said first means (A) may be placed at a location which is spaced apart therefrom.
  • said waveguide comprised in said third means (C), preferably in the form of a fiber, respectively the third means (C) comprising said waveguide is detachable from said at least one OLED or LED comprised in said first means (A) or from said second means (B), e.g. detachable from said planar structure.
  • said at least one luminescent material comprised in said second means (B) or the respective medical patch in which said luminescent material is incorporated
  • another luminescent material comprised in said second means (B) (or screen) intended for another particular use avoids the need of providing a complete set of first means (A) and second means (B) when the use changes. This is advantageous in view of economic aspects.
  • said waveguide comprised in said third means (C) is connectable to said first means (A) comprising at least one OLED or LED and/or to said second means (B) by a connector system.
  • said connector system comprises a plug and a socket, wherein the plug or the socket is physically connected to said waveguide, or the plug and the socket are physically connected to said first means (A) or said second means (B), respectively.
  • said waveguide may be, in particular repeatedly, detached from said first means (A) comprising at least OLED or LED or said second means (B).
  • said second means (B) comprises a receiving portion for receiving an end portion of said waveguide, which is configured to, preferably repeatedly, receives and physically connects to said end portion of said waveguide.
  • said receiving section comprises a cavity configured to contain an optical gel, wherein said optical gel forms an optical contact between said waveguide and said second means (B), in particular said at least one luminescent material.
  • the optical gel has an optical index which enables light from the end portion of the waveguide to be emitted, at least essentially without reflection back into the waveguide.
  • the optical index of such an optical gel may be adjusted by an concentrations of ions or molecules dissolved in said optical gel.
  • Optical gels are known in the art.
  • said optical gel is transparent for light with wavelengths emitted by said at least one OLED or LED, and/or with wavelengths for exciting said at least one luminescent material, and/or is filtering light with other wavelengths.
  • said optical index refers to the refractive index, the dispersion or a combination thereof.
  • said waveguide is in form of one or more optical fibers and the second means (B) comprises one or more additional optical fibers. At least one of said optical fibers is connected to one of said additional optical fibers by fusion splicing.
  • said second means (B) may be connected to said waveguide without the need of a connector system, e.g. a plug and a socket, thereby, in particular, reducing the weight and/or simplifying the production of the second means (B) and/or increasing the wear comfort by avoiding hard object near or at the second means (B).
  • said waveguide may also be connected in this way to said first means (A) comprising at least one OLED or LED.
  • said waveguide i.e. the optical fibers of said waveguide, may be cleaved.
  • said waveguide may be fusion spliced again.
  • an optical waveguide comprised in third means (C) is beneficial for decoupling the heat emitted from said OLED or LED from the luminescent material. This allows that e.g. only a light therapy or phototherapy, optionally including a cosmetic application, may be performed without applying heat.
  • the optical waveguide may also comprise an optical filter to remove radiation of undesired spectral ranges.
  • said luminescent material comprised in said second means (B) is located on the waveguide comprised in said third means (C). [00172] In one embodiment, said luminescent material comprised in second means
  • (B) is provided in a screen which in turn is located on an optical waveguide comprised in third means (C).
  • said luminescent material comprised in second means (B) is incorporated in the optical waveguide comprised in third means (C).
  • said first means (A) and said second means (B) are not in physical contact with one another.
  • said third means (C) connects the first means (A) to the second means (B), and thus also connects the second means (B) to the first means (A).
  • the waveguide comprised in third means (C), and thus also third means (C) which physically separates first means (A) and second means (B) from one another is characterized by a certain length.
  • the length is at least 10 cm or at least 50 cm, or at least 100 cm, or at least 100 cm, or at least 150 cm, or at least 200cm.
  • the upper limit of the length is not particularly limited. In one embodiment, the upper limit of the length is in the range of from 300 to 500 cm. [001801 Therapeutic application
  • the irradiation device defined therein is suitable for use in a therapeutic application, wherein the therapeutic application comprises or consists of the irradiation of a skin, a tissue or a muscle, or in a combination of two or three thereof, of a subject.
  • a skin and a tissue, or a skin or a muscle, or a tissue and a muscle, or a skin and a tissue and a muscle may be irradiated.
  • said therapeutic application is selected from the group consisting of: light therapy, photodynamic therapy, or heat therapy, or a combination of two or three thereof. Said terms have a well-accepted meaning in the medical field.
  • the medical patch or medical irradiation device according to the invention is suitable for use in light therapy.
  • the term light therapy encompasses the exposure of a person in need thereof to the light emitted from the luminescent material of the device according to the invention. This light is administered for a prescribed amount of time and, in some cases, at a specific time of day, to a person in need thereof.
  • the medical patch or medical irradiation device or the light therapy is suitable for use in the treatment of skin disorders.
  • skin disorders are selected from psoriasis, vitiligo, acne vulgaris, and skin cancer, reduction of inflammatory skin reactions, treatment of atopic dermatitis, or treatment of pruritus.
  • skin disorders are selected from eczema, atopic dermatitis, polymorphous light eruption or lichen planus.
  • the medical patch or medical irradiation device or the light therapy is suitable for use in wound healing.
  • the luminescent material comprised in the second means (B) of the irradiation device is selected such that it emits light in the wavelength range of from 1 ,400 to 2,000 nm when used in light therapy when being excited by said at least one OLED or LED comprised in said first means (A).
  • the medical patch or medical irradiation device or the light therapy is suitable for use in the treatment of mood and sleep related conditions.
  • mood and sleep related conditions are selected from seasonal affective disorders, non-seasonal depression and other psychiatric disturbances, including major depressive disorder, bipolar disorder and postpartum depression, and circadian rhythm sleep phase disorders.
  • the irradiation device or the light therapy is suitable for use in the treatment of individuals on shift work, and for jet lag.
  • the medical patch or medical irradiation device or the light therapy provided by said irradiation device is suitable for use in the treatment of natal jaundice.
  • the fluorescent material of the irradiation device is selected such that it emits light in the wavelength range of about 450 nm (emission maximum) when used in the treatment of natal jaundice.
  • the medical patch or medical irradiation device is suitable for use in photodynamic therapy.
  • photodynamic therapy encompasses the exposure of a person in need thereof to nontoxic light-sensitive compounds that are exposed selectively to light, whereupon they become toxic to targeted malignant and other diseased cells.
  • photodynamic therapy is synonymously used with the term “photochemotherapy” .
  • the photodynamic therapy involves three key compounds, i.e. a photosensitizer, the irradiation device, and tissue oxygen.
  • a photosensitizer i.e. a photosensitizer
  • the irradiation device i.e. a photoensitizer
  • tissue oxygen i.e. a tissue oxygen
  • the combination of these three components leads to the chemical destruction of any tissues which have either selectively taken up the photosensitizer or have been locally exposed to light.
  • the wavelength of the light source needs to be appropriate for exciting the photosensitizer to produce reactive oxygen species.
  • These reactive oxygen species generated through photodynamic therapy are free radicals (Type I photodynamic therapy) generated through electron abstraction or transfer from a substrate molecule and highly reactive state of oxygen known as singlet oxygen (Type II photodynamic therapy).
  • Suitable photosensitizers are known in the art such as porphyrins, chlorophylls, dyes, aminolevulinic acid, silicon phthalocyanine, m- tetrahydroxyphenylchlo n, and mono-L-aspartyl chlorine e6.
  • the luminescent material comprised in said second means (B) is selected such that it emits light in the wavelength range of red light to near infrared light (NIR) when being excited by said at least one OLED or LED comprised in said first means (A).
  • the medical patch or medical irradiation device or the photodynamic therapy is suitable to be used for treating malignant cancer.
  • the medical patch or medical irradiation device or the photodynamic therapy provided by said patch or irradiation device is suitable to be used to kill microbial cells, including bacteria, fungi and viruses.
  • the medical patch or medical irradiation device or the photodynamic therapy provided by said patch or irradiation device is suitable to be used to treat acne.
  • the medical patch or medical irradiation device or the photodynamic therapy is suitable to be used to treat wet age-related macular degeneration.
  • the medical patch or medical irradiation device is suitable to be used in heat therapy.
  • heat therapy encompasses the application of heat to the body of a subject for pain relief and health.
  • thermalotherap is synonymously used with the term “thermotherap .
  • the luminescent material comprised in said second means (B) of the irradiation device is selected such that it emits light in the wavelength range of from 800 to 2,000 nm when used in heat therapy and when being excited by said at least one OLED or LED comprised in said first means (A).
  • Heat is typically applied by subjecting the relevant body part of a subject to the irradiation device.
  • the medical patch or medical irradiation device or the heat therapy provided by said patch or irradiation device is suitable to be used for the treatment of arthritis, stiff muscles, injuries to the deep tissue of the skin, and rheumatoid arthritis.
  • the medical patch or medical irradiation device or the heat therapy provided by said patch or irradiation device is suitable to be used for rehabilitation purposes.
  • the medical patch or medical irradiation device or the heat therapy provided by patch or said irradiation device is suitable to be used for increasing the extensibility of collagen tissue, decreasing joint stiffness, reducing pain, relieving muscle spasms, myalgia, fibromyalgia, contracture, and bursitis, reducing inflammation, edema, and aids in the post-acute phase of healing; and increasing blood flow.
  • the medical patch or medical irradiation device or the heat therapy is suitable to be used for the treatment of infection and cancers.
  • the medical patch or medical irradiation device or the heat therapy provided by said irradiation device is suitable to be used for the treatment of headaches and migraines.
  • hyperpigmentation e.g. melasma, age spots, freckles, darker skin types, and / or general pigmentation problems are treated.
  • rosacea is treated.
  • the luminescent material comprised in said second means (B) is selected such that it emits light in a wavelength range of approx. 430 nm (emission maximum) when being excited by said at least one OLED or LED comprised in said first means (A). Such irradiation device may be suitable to be used for suppressing melatonin generation.
  • the luminescent material comprised in said second means (B) is selected such that it emits light in a wavelength range of approx. 450 nm (emission maximum) when being excited by said at least one OLED or LED comprised in said first means (A).
  • Such irradiation device may be suitable to be used for treating neonatal jaundice.
  • the luminescent material comprised in said second means (B) is selected such that it emits light in a wavelength range of approx. 453 nm (emission maximum) when being excited by said at least one OLED or LED comprised in said first means (A).
  • Such irradiation device may be suitable to be used for relieving pains. It is believed that by means of such radiation the generation of NO is improved which in turn is responsible for relieving pains.
  • the luminescent material comprised in said second means (B) is selected such that it emits light in a wavelength range of from 580-630 nm when being excited by said at least one OLED or LED comprised in said first means (A).
  • Such irradiation device may be suitable to be used in the light orange ultraviolet therapy. Such therapy may improve the perfusion of heart and circulation, the secretion of kidneys, bowels and the skin, and/or the regulation of the nervous system and glands.
  • the luminescent material comprised in said second means (B) is selected such that it emits light in a wavelength range of approx. 800 - 1 ,400 nm when being excited by said at least one OLED or LED comprised in said first means (A).
  • Such irradiation device may be suitable to be used for treating hypertension.
  • the luminescent material comprised in said second means (B) is selected such that it emits light in a wavelength range of approx. 1 ,400 - 2,000 nm when being excited by said at least one OLED or LED comprised in said first means (A).
  • Such irradiation device may be suitable to be used for wound healing.
  • the treatment comprises post-laser resurfacing or post- aesthetic treatment, e.g. after filler treatment to enhance wound healing.
  • the luminescent material comprised in said second means (B) is selected such that it emits light in the wavelength range of red light or NIR when being excited by said at least one OLED or LED comprised in said first means (A).
  • Such irradiation device may be suitable to be used for treating acne.
  • the luminescent material comprised in said second means (B) is selected such that it emits light in the wavelength range of from 650 nm to 1 ,300 nm when being excited by said at least one OLED or LED comprised in said first means (A). Radiation or light of this wavelength range is capable of penetration up to a depth of 5 mm into irradiated portions of the body of a human or an animal. Accordingly, said irradiation device may be suitable to be used in the therapy of stressed muscles, for muscle relaxation, improvement of perfusion, reduction of viscosity of synovial fluid, and/or the improvement of collagen formation.
  • the luminescent material comprised in said second means (B) is selected such that it emits light in the wavelength range of NIR when being excited by said at least one OLED or LED comprised in said first means (A), wherein the irradiation device further comprises a light source that may emit blue or violet light.
  • a light source that may emit blue or violet light.
  • Such irradiation device may be suitable to be used for repairing DNA damages or is suitable for use in the treatment of DNA damages. It is believed that by means of such irradiation device the activity of enzymes such as photolyases may be increased which in turn may be responsible for the repair of light-induced DNA damages.
  • the luminescent material is selected from the luminescent material comprised in said second means (B) such that said luminescent material emits light in the wavelength range of from 650 to 1 ,300 nm. Radiation or light of this wavelength range is capable of penetration up to a depth of 5 mm into irradiated portions of the body of a subject, i.e. a human or an animal.
  • the irradiation device according to the invention is particularly effective in the therapy of stressed muscles, for muscle relaxation, improvement of perfusion, reduction of viscosity of synovial fluid, and/or the improvement of collagen formation.
  • said irradiation device may be suitable to be used for increasing blood flow (perfusion) of the skin and sub-cutaneous tissue, for supporting the formation of collagen tissue, and for increasing the extensibility of collagen tissue.
  • said therapeutic application comprises a cosmetic and / or aesthetic application or results in an aesthetic improvement of the skin.
  • the term "cosmetic” encompasses the term “aesthetic”.
  • the aesthetic improvement concerns skin problems arising from hyperpigmentation, e.g. melasma, age spots, freckles, darker skin types, and / or general pigmentation problems.
  • the aesthetic improvement concerns amelioration of general facial redness.
  • the aesthetic improvement concerns amelioration of rosacea.
  • the aesthetic improvement concerns post-laser resurfacing or post-aesthetic treatment, e.g. after filler treatment to enhance wound healing.
  • the cosmetic and/or aesthetic application is selected from the group consisting of: removal of macula, removal of tattoos, removal of hairs (epilation), reduction of wrinkles, or reduction of scar tissue, treatment of hair loss, treatment or amelioration of cellulite, non-invasive treatment to improve aesthetic impression of under-chin, neck and decolletage.
  • cellulite also known as orange peel syndrome
  • the luminescent material of the medical patch or irradiation device is selected such that it emits light in the wavelength range of from 680 nm to 1 , 100 nm such as 680 nm to 700 nm (emission maxima) when used for removing macula or tattoos.
  • the luminescent material of the medical patch or irradiation device is selected such that it emits light in the wavelength range of about 800 nm such as 810 nm (emission maximum) when used for removing hairs.
  • the luminescent material of the medical patch or irradiation device is selected such that it emits light in the wavelength range of near infrared radiation (NIR) when used for reducing wrinkles or scar tissue or the treatment of hair loss.
  • NIR near infrared radiation
  • the invention relates to a method of irradiating a skin, a tissue or a muscle, or a combination of two or three thereof, of a subject, the method at least comprising: irradiating said skin, tissue or muscle, or a combination of two or three thereof, of said subject, by means of a medical patch or a medical irradiation device as defined in the first aspect and the second aspect or any embodiment defined therein.
  • said irradiation is a light therapy, photodynamic therapy, or heat therapy, or a combination of two or three thereof.
  • said irradiation is a therapy of stressed muscles, relaxation of muscles, improvement of perfusion, reduction of viscosity of synovial fluid, improvement of collagen formation, treatment of DNA damages, reduction of inflammatory skin reactions, treatment of atopic dermatitis, and/or treatment of pruritus.
  • said method comprises a cosmetic and / or aesthetic application.
  • said cosmetic and / or aesthetic application is selected from the group consisting of: removal of macula, removal of tattoos, removal of hairs (epilation), reduction of wrinkles, or reduction of scar tissue, treatment of hair loss, treatment or amelioration of cellulite, non-invasive treatment to improve aesthetic impression of under-chin, neck and decolletage.
  • said method is a cosmetic and / or aesthetic application.
  • said cosmetic and / or aesthetic application is selected from the group consisting of: removal of macula, removal of tattoos, removal of hairs (epilation), reduction of wrinkles, or reduction of scar tissue, treatment of hair loss, treatment or amelioration of cellulite, non-invasive treatment to improve aesthetic impression of under-chin, neck and decolletage.
  • the light emitted by said second means (B) either of the medical patch according to the invention or the medical device according to the invention may be used for performing a therapeutic treatment or a cosmetic treatment or an aesthetic treatment or two or more thereof of a subject.
  • the medical patch is brought into contact with the subject, i.e. into physical contact, preferably with a portion of the skin of the subject.
  • the treatment is therapeutic and cosmetic or therapeutic and aesthetic or therapeutic and cosmetic and aesthetic. In another embodiment, treatment is cosmetic and aesthetic.
  • the subject may be a human or an animal.
  • the invention relates to a method of performing a therapeutic treatment or a cosmetic treatment or an aesthetic treatment or a combination of two or more thereof of a subject, the method comprising: directing light emitted from said second means (B) of the medical patch according to the invention, onto the subject, wherein said medical patch contacts said subject.
  • the invention relates to a method of performing a therapeutic treatment or a cosmetic treatment or an aesthetic treatment or a combination of two or more thereof of a subject, the method comprising: directing light emitted from said second means (B) of the medical device according to the invention onto the subject.
  • said therapeutic application is selected from the group consisting of: light therapy, photodynamic therapy, or heat therapy, or a combination of two or three thereof.
  • said light emitted from the second means (B) is used in a light therapy, a photodynamic therapy, or a heat therapy, or a combination of two or three thereof.
  • Fig. 1 exemplarily shows one embodiment of an irradiation device suitable for use according to the invention.
  • Medical irradiation device 10 comprises first means 1 , second means 2, and third means 3.
  • First means 1 comprises a blue LED which is accommodated in a housing comprising an electric circuit for switching said LED on and off as indicated in said figure.
  • Means 1 is connected to means 3 which is an optical waveguide. Waveguide 3 may be flexible.
  • Said means 2 is construed in the form of a plate-!ike arrangement.
  • Waveguide 3 is connected to means 2 at an edge thereof.
  • Means 2 includes a luminescent material 2a, which is incorporated in a gel-like polymeric material 2b.
  • Fig. 2 exemplarily shows another embodiment of a medical irradiation device according to the invention.
  • Medical irradiation device 100 comprises first means 1 , second means 2, and third means 3.
  • First means 1 comprises a blue LED which is accommodated in a housing comprising an electric circuit for switching said LED on and off as indicated in said figure.
  • Means 1 is connected to means 3 which is a waveguide.
  • Waveguide 3 may be flexible.
  • Means 2 is construed in the form of a plate-like arrangement.
  • Waveguide 3 is connected to means 2 at the centre thereof. Further, waveguide 3 includes a lens 3a for effectively guiding light to second means 2.
  • Second means 2 includes a luminescent material 2a, which is incorporated in a gel-like polymeric material 2b.
  • Second means 2 is covered by cover means 2c, e.g. in the form of a textile tissue, wherein said second means (B) has a light emitting surface where emitted light leaves said surface (symbolized by arrows), and the cover means (G) prevents light being emitted from other surfaces of the second means (B) than said light emitting surface.
  • the invention relates to the following items 1 to 15:
  • Medical patch comprising: a light entry portion (X);
  • a light emitting portion Z; and further comprising first means (A), second means (B) and third means (C); (X) being configured to receive light from said third means (C) comprising an optical waveguide;
  • Y comprising said second means (B) comprising at least one luminescent material configured to emit light by converting light emitted from at least one OLED or LED (A); in one embodiment, said luminescent material is a luminescent organic compound or a quantum dot-comprising material;
  • (C) third means comprising said optical waveguide is configured to guide said light emitted by said at least one OLED or LED comprised in said first means (A) to said at least one luminescent material comprised in said second means (B).
  • said third means (C) receives the light from said first means (A) and emits the light in a first light direction, wherein the second means (B) is configured to emit light in a second light direction, which differs from the first light direction by an angle a, preferably by 0° ⁇ a ⁇ 90°.
  • said at least one LED comprised in the first means (A) comprises (ln,Ga)N or (AI,ln,Ga)N and is configured to emit light in the wavelength range of from 370 to 480 nm; wherein said at least one luminescent material comprised in the second means
  • (B) comprises a luminescent organic compound or a quantum dot comprising material, preferably selected from the group comprising or consisting of: a perylene dye, a triphenylene dye, a naphthalimide dye, a xanthene dye, a phenoxazine dye, an acridine dye, an anthracene dye, a phenazine dye, or a coumarin dye, or two or more thereof; or wherein said at least one luminescent material comprised in the second means (B) comprises a compound selected from the group comprising or consisting of:
  • said optical waveguide comprised in the third means (C) is in the form of a fiber. Medical patch according to any one of the preceding items, wherein at least a part of said optical waveguide comprised in the third means (C) forms at least a part of the second means (B). Medical patch according to any one of the preceding items, wherein said optical waveguide comprised in said third means (C) is configured to be detachable from the first means (A) or from the second means (B) or from the first means (A) and the second means (B). Medical irradiation device comprising:
  • (B) second means comprising at least one luminescent material configured to emit light by converting said light emitted from said at least one first means
  • (A) comprising at least one OLED or LED; wherein said luminescent material is a luminescent organic compound or a quantum dot-comprising material;
  • (C) third means comprising an optical waveguide configured to guide said light emitted by said at least one OLED or LED comprised in said first means (A) to said at least one luminescent material comprised in said second means
  • Luminescent material for use in the irradiation of a skin, a tissue or a muscle, or a combination of two or three thereof, of a subject, the luminescent material being comprised in an irradiation device, the irradiation device comprising:
  • (B) second means comprising at least one luminescent material configured to emit light by converting said light emitted from said at least one OLED or LED (A); wherein said luminescent material is a luminescent organic compound or a quantum dot-comprising material;
  • (C) third means comprising an optical waveguide configured to guide said light emitted by said at least one OLED or LED comprised in said first means (A) to said at least one luminescent material comprised in said second means
  • said third means (C) connects the first means (A) to the second means (B);
  • said light emitted by said at least one luminescent material comprised in said second means (B) is used for said irradiation of a skin, a tissue or a muscle, or a combination of two or three thereof, of said subject.
  • igns medical irradiation device first means including a blue second means
  • CaS:Eu 2+ [luminescent material comprised in the first means (B)] coated with Si0 2 [coating material (E)] is suspended in a commercial liquid silicone resin precursor. Subsequently, a polymerization catalyst is added to said suspension. Immediately after the addition of the catalyst, a defined portion of the resulting mixture is applied onto a waveguide [waveguide comprised in third means (C)] based on poly(methylmethacrylate).
  • the resulting structure may be defined as a screen containing said luminescent material comprised in the second means (B), wherein said screen is provided on a waveguide comprised in said third means (C). This structure is attached to an LED array based on (ln,Ga)N [LED (A)].
  • the spectrum of said irradiation device shows an emission maximum at 455 nm stemming from said LED comprised in first means (A) and a further emission maximum at 650 nm stemming from said luminescent material comprised in second means (B).
  • the intensity of light emitted by the luminescent material varies in dependence of the thickness of the polymer layer applied to said waveguide.
  • SrGa 2 S 4 :Eu 2+ [luminescent material comprised in second means (B)] coated with Si0 2 [coating material (E)] is suspended in a commercial liquid silicone precursor. Subsequently, a polymerization catalyst is added to said suspension. Immediately after the addition of the catalyst, a defined portion of the resulting mixture is applied onto a waveguide [waveguide vomprised in third means (C)] based on poly(methylmethacrylate).
  • the resulting structure may be defined as a screen containing said luminescent material, wherein said screen is provided on a waveguide comprised in third means (C).
  • the resulting structure is attached to an LED array based on (ln,Ga)N [LED comprised in first means (A)].
  • the spectrum of said irradiation device shows an emission maximum at 455 nm stemming from said LED and a further emission maximum at approx., 535 nm stemming from said luminescent material
  • the intensity of light emitted by the luminescent material varies in dependence of the thickness of the polymer layer applied to the waveguide.
  • SrLi 2 Si0 4 :Eu 2+ [luminescent material comprised in second means (B)] coated with Si0 2 [coating material (E)] is suspended in a commercial liquid silicone resin precursor. Subsequently, a polymerization catalyst is added to said suspension. Immediately after the addition of the catalyst, a defined portion of the resulting mixture is applied onto a waveguide [waveguide comprised in third means (C)] based on poly(methyimethacrylate).
  • the resulting structure may be defined as a screen containing said luminescent material comprised in the second means (B), wherein said screen is provided on a waveguide comprised in third means (C).
  • the resulting structure is attached to an LED array based on (ln,Ga)N [LED (A)].
  • the spectrum of said irradiation device shows an emission maximum at 455 nm stemming from said LED comprised in first means (A) and a further emission maximum at 580 nm stemming from said luminescent material comprised in second means (B).
  • the intensity of light emitted by the luminescent material varies in dependence of the thickness of the polymer layer applied to said waveguide.
  • CaAISiN 3 :Eu 2+ [luminescent material B] coated with Si0 2 [coating material (E)] is suspended in a commercial liquid silicone resin precursor. Subsequently, a polymerization catalyst is added to said suspension. Immediately after the addition of the catalyst, a defined portion of the resulting mixture is applied onto a waveguide [waveguide (C)] based on poly (methylmethacrylate).
  • the resulting structure may be defined as a screen containing said luminescent material (B), wherein said screen is provided on a waveguide (C). The resulting structure is attached to an LED array based on (ln,Ga)N [LED (A)].
  • the spectrum of said irradiation device shows an emission maximum at 455 nm stemming from said LED (A) and a further emission maximum at 650 nm stemming from said luminescent material (B).
  • the intensity of light emitted by the luminescent material (B) varies in dependence of the thickness of the polymer layer applied to waveguide (C).
  • Lumogen® F Red 305 [luminescent material comprised in the second means (B)] is suspended in a commercial liquid silicone resin precursor. Subsequently, a polymerization catalyst is added to said suspension. Immediately after the addition of the catalyst, a defined portion of the resulting mixture is applied onto a waveguide [waveguide comprised in third means (C)] based on poly(methylmethacrylate).
  • the resulting structure may be defined as a screen containing said luminescent material comprised in the second means (B), wherein said screen is provided on a waveguide comprised in said third means (C). This structure is attached to an LED array based on (ln,Ga)N [LED (A)].
  • the spectrum of said irradiation device shows an emission maximum at 470 nm stemming from said LED comprised in first means (A) and a further emission maximum at 670 nm stemming from said luminescent material comprised in second means (B).
  • the intensity of light emitted by the luminescent material varies in dependence of the thickness of the polymer layer applied to said waveguide.
  • Lumogen® F Orange 240 [luminescent material comprised in second means (B)] is suspended in a commercial liquid silicone precursor. Subsequently, a polymerization catalyst is added to said suspension. Immediately after the addition of the catalyst, a defined portion of the resulting mixture is applied onto a waveguide [waveguide comprised in third means (C)] based on poly(methylmethacrylate).
  • the resulting structure may be defined as a screen containing said luminescent material, wherein said screen is provided on a waveguide comprised in third means (C).
  • the resulting structure is attached to an LED array based on (ln,Ga)N [LED comprised in first means (A)].
  • the spectrum of said irradiation device shows an emission maximum at 470 nm stemming from said LED and a further emission maximum at approx., 570 nm accompanied by two further lower emissions at approx. 540 nm and 625 nm stemming from said luminescent material.
  • the intensity of light emitted by the luminescent material varies in dependence of the thickness of the polymer layer applied to the waveguide.
  • a mixture of Lumogen® F Yellow ED 206 and Lumogen® F Red 305 [luminescent material comprised in second means (B)] is suspended in a commercial liquid silicone resin precursor. Subsequently, a polymerization catalyst is added to said suspension. Immediately after the addition of the catalyst, a defined portion of the resulting mixture is applied onto a waveguide [waveguide comprised in third means (C)] based on poly(methylmethacrylate).
  • the resulting structure may be defined as a screen containing said luminescent material comprised in the second means (B), wherein said screen is provided on a waveguide comprised in third means (C).
  • the resulting structure is attached to an LED array based on (ln,Ga)N [LED (A)].
  • the spectrum of said irradiation device shows an emission maximum at 470 nm stemming from said LED comprised in first means (A) and a further emissions at 520 nm, 550 nm and 605 nm nm stemming from said luminescent materials comprised in second means (B).
  • the intensity of light emitted by the luminescent material varies in dependence of the thickness of the polymer layer applied to said waveguide.

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Health & Medical Sciences (AREA)
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Abstract

L'invention concerne un dispositif d'irradiation médicale qui comprend : (A) un premier moyen comprenant au moins une DELO ou une LED conçue pour émettre de la lumière ; (B) un deuxième moyen comprenant au moins un matériau luminescent conçu pour émettre de la lumière par conversion de ladite lumière émise par ledit premier moyen comprenant au moins une DELO ou une DEL (A) ; ledit matériau luminescent étant un composé organique luminescent ou un matériau comprenant un point quantique ; (C) un troisième moyen comprenant un guide d'ondes optique conçu pour guider ladite lumière émise par ladite ou lesdites DELO ou DEL comprise dans ledit premier moyen (A) vers ledit ou lesdits matériaux luminescents compris dans ledit deuxième moyen (B) ; ledit troisième moyen (C) reliant le premier moyen (A) au deuxième moyen (B).
PCT/EP2017/058960 2016-04-15 2017-04-13 Dispositif d'irradiation médicale WO2017178601A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP16165562.6 2016-04-15
EP16165562 2016-04-15
EP16000920.5 2016-04-22
EP16000920 2016-04-22

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WO2017178601A1 true WO2017178601A1 (fr) 2017-10-19

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120182758A1 (en) * 2011-01-17 2012-07-19 Nath Guenther Light guide assembly and optical illumination apparatus
US20120289885A1 (en) * 2011-05-14 2012-11-15 William Jude Cottrell Phototherapy system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120182758A1 (en) * 2011-01-17 2012-07-19 Nath Guenther Light guide assembly and optical illumination apparatus
US20120289885A1 (en) * 2011-05-14 2012-11-15 William Jude Cottrell Phototherapy system

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