WO2017156423A3 - Broadly protective antibody cocktails for treatment of filovirus hemorrhagic fever - Google Patents

Broadly protective antibody cocktails for treatment of filovirus hemorrhagic fever Download PDF

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Publication number
WO2017156423A3
WO2017156423A3 PCT/US2017/021842 US2017021842W WO2017156423A3 WO 2017156423 A3 WO2017156423 A3 WO 2017156423A3 US 2017021842 W US2017021842 W US 2017021842W WO 2017156423 A3 WO2017156423 A3 WO 2017156423A3
Authority
WO
WIPO (PCT)
Prior art keywords
filovirus
treatment
hemorrhagic fever
protective antibody
antibody cocktails
Prior art date
Application number
PCT/US2017/021842
Other languages
French (fr)
Other versions
WO2017156423A2 (en
Inventor
Mohammad Javad Aman
Frederick Wayne Holtsberg
Laurence Mitchell ZEITLIN
Zachary Asa BORNHOLDT
Original Assignee
Integrated Biotherapeutics, Inc.
Mapp Biopharmaceutical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Integrated Biotherapeutics, Inc., Mapp Biopharmaceutical, Inc. filed Critical Integrated Biotherapeutics, Inc.
Publication of WO2017156423A2 publication Critical patent/WO2017156423A2/en
Publication of WO2017156423A3 publication Critical patent/WO2017156423A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

This disclosure provides a method for preventing, treating, or managing a filovirus infection in a subject, where the method includes administering to a subject in need thereof an effective amount of at least two anti-filovirus glycoprotein antibodies or antigen-binding fragments thereof where at least one of the antibodies or fragments binds to its orthologous filovirus glycoprotein epitope on two or more filovirus species or strains.
PCT/US2017/021842 2016-03-11 2017-03-10 Broadly protective antibody cocktails for treatment of filovirus hemorrhagic fever WO2017156423A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662307118P 2016-03-11 2016-03-11
US62/307,118 2016-03-11
US201662368688P 2016-07-29 2016-07-29
US62/368,688 2016-07-29

Publications (2)

Publication Number Publication Date
WO2017156423A2 WO2017156423A2 (en) 2017-09-14
WO2017156423A3 true WO2017156423A3 (en) 2017-10-19

Family

ID=59789746

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2017/021842 WO2017156423A2 (en) 2016-03-11 2017-03-10 Broadly protective antibody cocktails for treatment of filovirus hemorrhagic fever

Country Status (1)

Country Link
WO (1) WO2017156423A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018057916A1 (en) * 2016-09-24 2018-03-29 The Trustees Of The University Of Pennsylvania Novel humanized anti-ebola antibodies useful in preventing ebola infections
AU2018221172A1 (en) * 2017-02-17 2019-09-05 Adimab, Llc Monoclonal antibodies and cocktails for treatment of Ebola infections
EP3583122A4 (en) * 2017-02-17 2020-11-11 Mapp Biopharmaceutical, Inc. Monoclonal antibodies and cocktails for treatment of ebola infections

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120014958A1 (en) * 2008-06-25 2012-01-19 Esbatech, An Alcon Biomedical Research Unit Llc Stable and soluble antibodies inhibiting vegf
US20150232556A1 (en) * 2012-09-19 2015-08-20 Innate Pharma Kir3dl2 binding agents
WO2015200522A2 (en) * 2014-06-25 2015-12-30 Integrated Biotherapeutics, Inc. Monoclonal antibodies directed against envelope glycoproteins from multiple filovirus species
WO2016069627A1 (en) * 2014-10-28 2016-05-06 Integrated Biotherapeutics, Inc. Non-human primate-derived pan-ebola and pan-filovirus monoclonal antibodies directed against envelope glycoproteins
WO2016145385A2 (en) * 2015-03-11 2016-09-15 Integrated Biotherapeutics, Inc. Pan-ebola and pan-filovirus protective epitopes, antibodies, and antibody cocktails
WO2016179511A1 (en) * 2015-05-07 2016-11-10 Mapp Biopharmaceutical, Inc. Monoclonal antibody cocktails for treatment of ebola infections
US20170088606A1 (en) * 2013-06-03 2017-03-30 Albert Einstein College Of Medicine, Inc. Therapy for filovirus infection

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120014958A1 (en) * 2008-06-25 2012-01-19 Esbatech, An Alcon Biomedical Research Unit Llc Stable and soluble antibodies inhibiting vegf
US20150232556A1 (en) * 2012-09-19 2015-08-20 Innate Pharma Kir3dl2 binding agents
US20170088606A1 (en) * 2013-06-03 2017-03-30 Albert Einstein College Of Medicine, Inc. Therapy for filovirus infection
WO2015200522A2 (en) * 2014-06-25 2015-12-30 Integrated Biotherapeutics, Inc. Monoclonal antibodies directed against envelope glycoproteins from multiple filovirus species
WO2016069627A1 (en) * 2014-10-28 2016-05-06 Integrated Biotherapeutics, Inc. Non-human primate-derived pan-ebola and pan-filovirus monoclonal antibodies directed against envelope glycoproteins
WO2016145385A2 (en) * 2015-03-11 2016-09-15 Integrated Biotherapeutics, Inc. Pan-ebola and pan-filovirus protective epitopes, antibodies, and antibody cocktails
WO2016179511A1 (en) * 2015-05-07 2016-11-10 Mapp Biopharmaceutical, Inc. Monoclonal antibody cocktails for treatment of ebola infections

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MURIN, CD ET AL.: "Structures of protective antibodies reveal sites of vulnerability on Ebola virus", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE U.S.A., vol. 111, no. 48, 2 December 2014 (2014-12-02), pages 17182 - 17187, XP055321303 *
SUNDLING, C ET AL.: "Single- cell and deep sequencing of IgG-switched macaque B cells reveal a diverse immunoglobulin repertoire following immunization", JOURNAL OF IMMUNOLOGY, vol. 192, no. 8, 15 April 2015 (2015-04-15), pages 3637 - 3644, XP055432919 *

Also Published As

Publication number Publication date
WO2017156423A2 (en) 2017-09-14

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