WO2017153640A1

WO2017153640A1 - Dressing in the form of a self-adhesive tape

Info

Publication number: WO2017153640A1
Application number: PCT/FR2016/050529
Authority: WO
Inventors: Jean-Marc Pernot
Original assignee: Urgo Recherche Innovation Et Developpement
Priority date: 2016-03-08
Filing date: 2016-03-08
Publication date: 2017-09-14
Also published as: EP3426207A1; FR3048607A1

Abstract

The invention relates to a new dressing in the form of a self-adhesive tape to be used for promoting or activating hemostasis. Said tape consists of a self-adhesive nonwoven fabric obtained from agglomerated short fibers that have been crimped. The fibres are preferably made of polyester. The dressing can also include an additional layer.

Description

Dressing in the form of a self-adhesive band

The occurrence of a vascular wound leads to the establishment of a defense mechanism to prevent blood leakage. A lesion located on capillaries will involve primary haemostasis that can stop the bleeding by forming a "platelet". Primary haemostasis will be enhanced by plasma coagulation, which will come into play to form an insoluble and solid fibrin clot. This clot also serves as a matrix for the migration of cells involved in healing. When the healing of the vessel is complete, the mechanisms of fibrinolysis will allow clot dissolution, which is an obstacle to free vascular circulation. Haemostatic products, which promote or activate hemostasis, can intervene at several levels to help stop bleeding. The use of various haemostatic products has long been known to treat hemostasis.

Haemostatic products act mainly on haemostasis by reproducing the last stage of coagulation. Fibrinogen is transformed into fibrin, under the action of thrombin. Fibrinogen then divides into fibrin and fibrinopeptide monomers. The fibrin monomers aggregate and form a fibrin clot. Physiologically, the activated Factor XIII (FXIIIa) will stabilize the clot by creating internal bonds between the fibrin monomers. During wound healing, the increase in fibrinolytic activity is induced by plasmin, and the degradation of fibrin is initiated. The proteolytic degradation of fibrin can be inhibited by antifibrinolytics (tranexamic acid, aprotinin, etc.).

Hemostatic products with no specific action on the cascade of events occurring during coagulation will, in turn, contribute to stop bleeding, by acting nonspecifically on the different phases of hemostasis and coagulation.

Among these products, there may be mentioned, by way of example, collagen, gelatin, the combination of bovine thrombin with gelatin, alginates, oxidized cellulose, polysaccharides, aldehydes, cyanoacrylates or polyethylene glycols.

Collagen is a tissue protein found in the media of the wall of blood vessels. When vascular breccias appear, circulating platelets are exposed to collagen, adhere to these fibers and initiate their activation process. The contribution of exogenous collagen makes it possible, by increasing the adhesion surface, to promote this step, which results in the formation of the platelet nail and participates in the activation of the coagulation. Gelatin is a collagen breakdown product that, in contact with blood, increases in volume and forms a gelatinous plug that fills the wound and mechanically opposes the flow of blood. Under the effect of the expansion of gelatin, the gel becomes saturated with blood, concentrates blood elements and promotes platelet activation. The physical matrix constituted by the gelatin network helps to stabilize the clot.

The combination of bovine thrombin with the gelatin matrix adds a direct action on the coagulation cascade. The blood circulates between the gelatin granules and is locally exposed to high concentrations of thrombin, which intervenes to transform the fibrinogen of the patient into fibrin.

In contact with biological fluids, the exchange of Ca 2 + ions of the alginates against the Na + ions of the blood and exudate leads to the gradual transformation of the dry dressing into a gel. The release of Ca2 + ions promotes platelet activation and fibrinogenesis. The alginate fibers by their physical absorption capacity and their role of matrix participate in the formation of the clot.

Once saturated with blood, the oxidized cellulose swells and turns into a black or brown gelatinous mass that contributes to clot formation. This action seems to be due to a physical effect by compression and absorption of the blood, rather than a modification of the normal physiological mechanism of coagulation.

The hydrophilic microporous spherical particles of polysaccharides absorb the plasma by osmotic effect, form a gel which fills the wound and act by mechanical blocking of the blood flow.

The aldehydes act by forming an amide bond between two amino functions present on the amino acids of the tissue proteins and the aldehydes. These covalent bonds make it possible to create a stable bridging between the tissue proteins.

Cyanoacrylates are composed of various monomers which, under the action of a freshly mixed catalyst, polymerize and harden to form a tissue-adhering film and prevent bleeding by mechanical occlusion of blood flow.

Polyethylene glycols (PEGs) consist of precursors that, when mixed, polymerize to form a hydrogel. Anchorage of PEG particles to tissue proteins is provided by the formation of covalent bonds and creates a mechanical barrier.

In order to promote or activate hemostasis and particularly to promote or activate wound-related hemostasis, the use of a product according to the present invention has proved its effectiveness in treating and preventing prolonged bleeding. Indeed, it has been demonstrated that the product according to the present invention facilitates the coagulation of blood.

When used to stop bleeding, on a finger, for example, the dressing is in the form of a band is laid and wound with one or more turns depending on the strength of the desired band.

The dressing according to the present invention has the advantage:

- to be easy and quick to ask,

- To be thin, which improves its comfort and conformability,

- do not use latex or adhesive that may come into contact with the skin,

- to be tearable.

This dressing consists of a self-adhesive elastic band consists of a specific nonwoven which was obtained from short conjugated fibers which were crimped.

Nonwovens are generally textile materials that can not be used to make medical bandages or bandages because they are not elastic enough or stretchy. Also, have recently been developed nonwovens of curled fibers which have better properties of extensibility. Such products are described in the patent application WO 2008/015972, for their use as a retaining band or bandage, easily tearable.

Surprisingly, this dressing has remarkable haemostatic properties which make it particularly suitable for use in the activation or the promotion of haemostasis.

The band included in the dressing according to the invention is advantageously self-adhesive.

The fibers constituting the band are advantageously crimped uniformly in the direction of the thickness of the nonwoven, and have a mean radius of curvature preferably between 10 and 200 microns. The number of crimped fibers on the surface of the nonwoven is advantageously greater than 10 crimped fibers / cm.

The nonwoven preferably has a basis weight of between 10 g / m ² and 300 g / m ² .

In a particular embodiment, the subject of the invention is a dressing comprising a strip consisting of a nonwoven of crimped fibers obtained from conjugated short fibers, in which

the nonwoven has a basis weight of between 10 g / m ² and 300 g / m ² , said fibers are uniformly crimped in the direction of the thickness of the nonwovens, and have an average radius of curvature of between 10 and 200 microns, and

the number of crimped fibers on the surface of the nonwoven is greater than 10 crimped fibers / cm ² .

A variant of the present invention relates to a dressing which, in addition to the band, comprises at least one additional layer on one side of the nonwoven.

The nonwoven used in the context of the present invention is described in the patent application WO 2008/015972.

In general, the fibers that have been used to make the nonwoven are preferably conjugated, polymeric in nature, and non-continuous (short).

The conjugate fibers in the sense of the invention are "latching friable" fibers having an asymmetric or laminated structure, which have the property of curling under the effect of heating. They owe this property to the difference of thermal contraction coefficient of the polymers which constitute them.

These fibers advantageously consist of at least two polymers which have a different coefficient of thermal contraction. These polymers usually have softening points or different melting points. They may be chosen from thermoplastic polymers such as, for example: olefinic polymers (especially polymers of polyolefins C ₂ -4 such as low and medium density polyethylenes and polypropylenes), acrylic polymers (especially acrylonitrile polymers with acrylonitrile units) such as acrylonitrile / vinyl chloride copolymers), vinylacetal polymers (especially polyvinyl acetal polymers), chlororovinyl polymers (especially polyvinyl chlorides, vinyl chloride / vinyl acetate copolymers and vinyl chloride / acrylonitrile copolymers) , chlorovinylidene polymers (especially vinylidene chloride / vinyl chloride copolymers and vinylidene chloride / vinyl acetate copolymers), styrenic polymers (especially heat-resistant polystyrenes), polyester polymers (especially polyalkylene polymers C ₂ _ ₄ arylates such as polymers of polyethylene terephthalate, polytrimethylene terephthalate, polybutylene terephthalate and polyethylene naphthalate), polyamide polymers (especially aliphatic polyamide polymers such as polyamides 6, 6-6, 11, 12, 6-10 and 6 -12, semi-aromatic polyamide polymers, aromatic polyamide polymers such as polyphenylene isophthalamide, polyhexamethylene terephthalamide and polyparaphenylene terephthalamide), polycarbonate polymers (especially bisphenol A type polycarbonates), polyparaphenylene benzobisoxazole polymers, phenylene polysulfide polymers, polyurethane polymers, cellulosic polymers (especially cellulose esters), and the like. . These thermoplastic polymers may optionally contain other copolymerizable units.

When the heating of the fibers is carried out with high temperature steam, according to the preferred embodiment of the nonwoven, non-adhesive polymers are preferred in wet heat (or water-resistant hydrophobic or non-water-soluble polymers). softening or melting point greater than or equal to 100 ° C, such as, for example, polypropylene polymers, polyester polymers and polyamide polymers. These polymers make it possible to avoid fiber bonding by melting or softening the fibers. Polyester aromatic polymers and polyamide polymers are particularly preferred for their excellent stability, heat resistance and ability to form fibers.

According to a preferred embodiment of the present invention the fibers used are two-component. The two-component fibers may be composed of polymers of the same chemical family or polymers of different chemical families, provided they have different thermal contraction coefficients.

In one embodiment, the conjugated short fibers are bicomponent, the two components constituting them being polymers which have a softening point of greater than or equal to 100 ° C., said polymers being chosen from polypropylene polymers, polyester polymers and polyesters. or the polyamide polymers, and preferably are two different aromatic polyester polymers.

It is preferred that the two-component fibers consist of two polymers of the same chemical family: for example a homopolymer and a copolymer. It is indeed possible to lower the degree of crystallinity of the homopolymer, or even to make it amorphous, or to lower its melting point or its softening point, by copolymerizing the monomer with another. The difference in melting point or softening point of the two polymers may be for example of the order of 5 to 150 ° C, preferably 50 to 130 ° C, and more preferably 70 to 120 ° C. The proportion of copolymerizable monomer, relative to the total amount of monomers, is for example of the order of 1 to 50 mol%, preferably 2 to 40 mol%, and more preferably 3 to 30 mol% (particularly from 5 to 20 mol%). The weight ratio of the homopolymer and the copolymer can be chosen according to the fiber structure; it is for example, in terms of the homopolymer (A) / copolymer (B) ratio, of the order of 90/10 to 10/90, preferably of 70/30 to 30/70, and more preferably of 60/40 to 40/60. In a preferred embodiment, the bicomponent fibers consist of two aromatic polyester polymers and in particular the combination of a polyalkylene arylate homopolymer (a) and a polyalkylene arylate copolymer (b). The polyalkylene arylate homopolymer (a) may be a homopolymer of an aromatic dicarboxylic acid (especially a symmetrical aromatic dicarboxylic acid such as terephthalic acid or naphthalene-2,6-dicarboxylic acid) and an alkane component diol (especially ethylene glycol or butylene glycol). For example, a polymer of the polyalkylene terephthalate series such as polyethylene terephthalate (PET) or polybutylene terephthalate (PBT) is used, and usually a PET with an intrinsic viscosity of the order of 0.6 to 0.7 used for manufacture of ordinary PET fibers. The polyalkylene arylate copolymer (b) can be obtained from a first monomer for the preparation of the polyalkylene arylate homopolymer (a), and a second monomer selected from a dicarboxylic acid such as a dicarboxylic acid an asymmetric aromatic, an alicyclic dicarboxylic acid, an aliphatic dicarboxylic acid, a longer chain alkane-diol component than the alkane diol of the polyalkylene arylate polymer (a), and / or a diol carrying an ether linkage.

It is possible to use one or to associate several of these second monomers. Among these components, use is preferably made of:

an asymmetric aromatic dicarboxylic acid, in particular isophthalic acid, phthalic acid or sodium 5-sulfoisophthalic acid,

or an aliphatic dicarboxylic acid, in particular a C _1-12 aliphatic dicarboxylic acid such as adipic acid,

an alkane-diol, in particular 1,3-propanediol, 1,4-butanediol, 1,6-hexanediol or neopentylglycol,

a polyoxyalkylene glycol, especially diethylene glycol, triethylene glycol, polyethylene glycol or polytetramethylene glycol.

Among them, there is preferably chosen an asymmetric aromatic dicarboxylic acid such as isophthalic acid, and a polyoxyalkylene glycol such as diethylene glycol. The polyalkylene arylate copolymer (b) may optionally be a hard segment elastomer of alkylene arylate (ethylene terephthalate, butylene terephthalate) and flexible segments for example of (poly) oxyalkylene glycol. In the polyalkylene arylate copolymer (b), the proportion of dicarboxylic acid component intended to lower the melting point or the softening point relative to the total amount of dicarboxylic acid component is for example of the order of 1 to 50 mol%, preferably 5 to 50% by moles, and more preferably from 15 to 40% by moles. The proportion of diol component intended to lower the melting point or the softening point, relative to the total amount of diol component, is, for example, at most 30 mol%, and preferably at most 10 mol%, by example of the order of 0.1 to 10 mol%.

The cross section (perpendicular to the fiber length direction) of two-component fibers is not limited to the round shape (the ordinary form of solid fibers) and the modified shapes (flattened, elliptical, polygonal, 3- to 14-folate , T, H, V, dog bone (i), etc.), but may also be a hollow section. However, the round section is usually chosen.

For the transverse structure of the bicomponent fibers, mention may be made of the phased structures formed by a plurality of polymers, for example the heart-shell, island and sea type structures, mixed, parallel (side-by-side or multilayer laminate), radial (radial laminate), hollow radial, block or random. Among these structures, it is preferred, for a more spontaneous development of thermal crimping, an eccentric heart-bark type structure or parallel type. In the case of two-component fibers of the core-shell type and for example of the eccentric core-bark type, the core may consist of a polymer of the vinyl alcohol family such as an ethylene / vinyl alcohol copolymer or a polyvinyl alcohol, or a thermoplastic polymer having a melting point or a low softening point, for example a polystyrene or a low density polyethylene, provided that it allows crimping by having a thermal contraction coefficient deviation with the polymer constituting the bark.

In a particular embodiment, the two-component fibers have a side-by-side structure and consist of a first polymer which is a polyethylene terephthalate, and a second polymer which is a copolymer of an alkylene arylate with the isophthalic acid and / or diethylene glycol.

The average titer of the conjugated short fibers, in particular two-component, may for example be between 0.1 to 50 dtex, preferably between 0.5 and 10 dtex, and more preferably between 1 and 5 dtex (particularly between 1.5 and 3 dtex). ). If the title is too thin, not only are the fibers difficult to manufacture but they may lack strength. In addition, at the crimping stage, it is difficult to obtain beautiful serpentine crimps. If the title is too big, the fibers become stiff and make it difficult to develop sufficient crimping.

The average length of the conjugated short fibers before crimping may for example be between 10 and 100 mm, preferably between 20 and 80 mm, and more preferably between 25 and 75 mm (particularly between 40 and 60 mm). If the fibers are too short, in addition to the difficulty of forming the fiber web, entanglement of the fibers is insufficient in the crimping step and it is difficult to guarantee good strength and extensibility properties. If the fibers are too long, not only does it become difficult to form a web of uniformly weighted fibers, but the fibers become entangled excessively during the formation of the web, to the point of interfering with each other at the time of crimping and to prevent the development of extensibility. In addition, in the invention, the choice of the length of fiber in the aforesaid range allows some of the crimped fibers on the surface of the nonwoven to emerge moderately from said surface of the nonwoven and thus improve the non-woven self-adhesive which will be discussed later.

In one embodiment, the average titer of the conjugated short fibers is between 1 and 5 dtex, preferably between 1.5 and 3 dtex, and the average length of the conjugated short fibers is between 10 and 100 mm, and preferably between 40 and 60 mm.

The application of a heat treatment to these conjugate fibers has the effect of developing the crimp and printing them embossed crimps in the form of coils (spiral or "coil spring"). The average radius of curvature of the crimped fibers in the sense of the invention corresponds to the average radius of curvature of the circles formed by the loops of the coils of the crimped fibers; it may be between 10 and 200 microns, for example between 10 and 250 microns, preferably between 20 and 200 microns, preferably between 50 and 160 microns, and more preferably between 70 and 130 microns.

The average radius of curvature of the crimped fibers can be determined by electron microscopy according to the following method. A photograph (magnification × 100) of a nonwoven section is taken with a scanning electron microscope (SEM). Among the fibers appearing on the plate, one selects the fibers forming at least 1 spiral turn (serpentine) and one determines their radius of curvature like the radius of the circle traced along the spiral (radius of the circle when one observes the curly fiber in the direction of the axis of the coil). When the fiber draws an elliptical spiral, the radius of curvature is determined as the half-sum of the large and small diameters of the ellipse. To exclude fibers that have developed serpentine crimp insufficient and fibers appearing elliptical because of an oblique observation of the spiral, it was limited to elliptical fibers of ratio between large and small diameters between 0.8 and 1.2. The measurement on the SEM image of an arbitrary nonwoven section is made and the average is determined on a population of fibers n = 100.

When the crimping is carried out by steam at high temperature, the nonwoven according to the invention has the characteristic that the crimping of the conjugate fibers oriented approximately parallel to the planar direction is developed in a substantially uniform manner in the direction of thickness. In a non-woven section taken in the direction of the thickness, among the areas delimited by a partition in three equal parts in the direction of the thickness, the number of fibers forming at least 1 spiral crimped turn is for example, in the central part (inner layer), from 5 to 50 by 5 mm (planar length) and 0.2 mm (thickness), preferably from 10 to 50 by 5 mm (planar) and 0.2 mm (thickness) and more preferably 20 to 50 per 5 mm (planar) and 0.2 mm (thickness).

Since most of the curled fibers have their axis oriented in the planar direction and the number of crimps is uniform in the direction of thickness, the nonwoven exhibits a high extensibility (without containing rubber or elastomer), and good operational resistance (without any adhesives).

In the present description, by "areas delimited by a division into three equal parts in the direction of the thickness" is meant the different areas obtained when cutting the nonwoven into three equal slices oriented perpendicular to the thickness.

In the nonwoven, the uniformity of the crimp in the direction of the thickness can be defined by the ratio of curvature of fiber. By "fiber curl ratio" is meant the ratio L2 / L1 of the length of the bilaterally stretched fiber L2 at the distance L1 of both ends of the fiber in the curled state. This fiber curvature ratio (in particular in the central region in the direction of the thickness) is for example of the order of at least 1.3 (for example from 1.35 to 5), preferably from 1 to , 4 to 4 (for example from 1.5 to 3.5), and more preferably from 1.6 to 3 (particularly from 1.8 to 2.5).

When the fiber curl ratio is measured on the basis of electron micrographs of nonwoven sections, the length of fiber L2 does not correspond to the length of the fiber that would be obtained if the three-dimensional curled fiber was stretched and rectilinearized. She corresponds to the length of fiber on the plate that is obtained when stretching and rectilinearizes the fiber appearing curly bidimensionally on the plate. In other words, the fiber length on the plate that is measured according to the invention is less than the actual fiber length. When the development of the crimp is approximately uniform in the direction of the thickness, the fiber curvature ratio is also uniform in the direction of the thickness. The uniformity of the fiber curvature ratio can be evaluated by comparing, in a section taken in the direction of thickness, the fiber curl ratios obtained in the different layers delimited by a partition in three equal parts in the sense of thickness. Thus, in a section taken in the direction of the thickness, the fiber curvature ratios obtained in the various areas delimited by the division into three equal parts in the direction of the thickness are all within the aforementioned range, and the ratio of the minimum value to the maximum value of the fiber curvature ratio in the various domains (ratio of the area where the fiber curl ratio is minimal to the area where it is maximal) is for example of the order of at least 75% (for example 75 to 100%), preferably 80 to 99%, and more preferably 82 to 98% (particularly 85 to 97%).

According to one embodiment, the nonwoven has in a section taken in the direction of the thickness, a fiber curvature ratio of greater than or equal to 1.3 in each of the areas delimited by a division into three equal parts in the sense of thickness, and the ratio of the minimum value to the maximum value of the fiber curl ratio in the different fields is greater than 75%.

As a concrete method of measuring the fiber curl ratio and its uniformity, the method of taking a photograph of the nonwoven section under the electron microscope and measuring the fiber curl ratio on selected areas within the different areas of sharing in three equal parts in the direction of thickness. The measurement is carried out in each of the upper layers (recto domain), internal (central domain) and lower (backside domain), on domains which, in the direction of the length, are at least 2 mm, and in the direction of thickness, are positioned near the center of each layer and have the same thickness from one area to another. In addition, these measurement domains are parallel in the direction of the thickness, and are defined such that each contains at least 100 fiber fragments allowing the measurement of their curvature ratio (of the order of preferably from minus 300, and more preferably from 500 to 1000). After setting these measurement domains, the fiber curvature ratio of all the fibers in the domain is measured and the average value is calculated on each measurement domain, then the uniformity of the fiber curl ratio is calculated by comparing the domain showing the largest mean value and the domain showing the smallest mean value.

The measurement of the fiber curl ratio and its uniformity can be performed according to the following methodology. Take a photo (magnification × 100) of a section of non-woven fabric under an electron microscope and, in a part where the fibers appeared on the plate, the thickness is divided into three equal areas (front, inner and back layers), and near the center of each domain, measuring domains of at least 2 mm in the length direction and containing at least 500 measurable fiber fragments are defined. On these domains, we measure on the one hand the inter-end distance (the shortest distance) between the two ends of the fiber and on the other hand the fiber length (length of the fiber on the plate).

Specifically, when a fiber end emerges on the surface of the nonwoven, it is retained as such as the measuring end of the inter-end distance; when a fiber end is immersed in the nonwoven, the dive limit portion is held in the nonwoven (end plate) as the measuring end of the inter-end distance.

Among the imaged fibers, we exclude from the measurement those on which we can not isolate a continuity of at least 100 μιη. The fiber curvature ratio is calculated as the L2 / L1 ratio of the fiber length L2 to the inter-end distance L1 of the fibers. Then we calculate the average on each of the front, inner and back layers of the partition in three equal parts in the direction of the thickness. Finally, the uniformity of the fiber curvature ratio in the direction of the thickness is calculated from the ratio of its maximum and minimum values in the different layers.

The principle of the method of measurement of the fiber length is illustrated in FIGS. 4-a and 4-b of the patent application WO 2008/015972.

Fig.4- (a) illustrates the case of a fiber having one end emerging at the surface and the other end dipping into the nonwoven. The inter-end distance L1 is here the distance from one end of the fiber to the dive boundary portion in the nonwoven. On the other hand, the length of fiber L2 is the length obtained when the dimension of the observable fiber (part extending from the end of the fiber to the dive portion in the non-dimensional portion) is stretched bilaterally on the plate. woven). Fig.4- (b) illustrates the case of a fiber whose two ends plunge into the nonwoven. The inter-end distance L1 is here the distance of the two ends of the emerging portion to the surface of the nonwoven (ends on the plate). On the other hand, the length of fiber L2 is the length obtained when two-dimensionally stretched, on the plate, the fiber in the part emerging on the surface of the nonwoven.

For curled fibers in the form of a coil, the average pitch of the coil is for example of the order of 0.03 to 0.5 mm, preferably of 0.03 to 0.3 mm, and more preferably of 0.05 to 0.2 mm.

The nonwoven may also contain fibers that are not bi-component fibers. Among these additional single-component fibers, mention may be made, for example, of the polymer fibers already mentioned above, but also the cellulosic fibers such as, for example, natural fibers (wood wool, sheep's wool, silk, hemp), semi-synthetic fibers. synthetic (especially acetate fibers such as triacetate fibers) or regenerated fibers (rayon, lyocell). The average titre and the average length of the single-component fibers are preferably identical to those of the two-component fibers. A single species can be used or several species of these single-component fibers can be combined. Among these single-component fibers, preference is given in particular to regenerated fibers such as rayon fibers, semi-synthetic fibers such as acetate fibers, polyolefin fibers such as polypropylene or polyethylene fibers, and polyester fibers. and polyamide fibers.

It is preferred to associate with two-component fibers of a chemical family (eg polyester) single-component fibers of the same chemical family.

The weight ratio between the two-component fibers and the single-component fibers is, for example, of the order of 80/20 to 100/0 (for example from 80/20 to 99/1), preferably from 90/10 to 100/0. and more preferably 95/5 to 100/0.

The nonwoven may also contain actives or additives such as stabilizers, UV filters, light stabilizers, antioxidants, antibacterials, deodorants, fragrances, dyes, fillers, antistatic agents, flame, plasticizers, lubricants, or crystallization retarders. One or more of these actives or additives can be used. These additives can be supported on the surface of the fibers as well as inside the fibers.

In general, the assets are chosen from: anti-bacterials such as polymyxin B, penicillins (amoxycillin), clavulanic acid, tetracyclines, minocycline, chlorotetracycline, aminoglycosides, amikacin, gentamicin, neomycin, silver and its salts (Sulfadiazine argentic), probiotics;

antiseptics such as sodium mercurothiolate, eosin, chlorhexidine, phenylmercury borate, hydrogen peroxide, Dakin liquor, triclosan, biguanide, hexamidine, thymol, Lugol, Povidone iodine, Merbromine, Benzalkonium and Benzethonium Chloride, ethanol, isopropanol;

anti-virals such as Acyclovir, Famciclovir, Ritonavir;

anti fungal agents such as polyenes, Nystatin, Amphotericin B,

Natamycin, imidazoles (Miconazole, Ketoconazole, Clotrimazole, Ecconazole, Bifonazole, Butoconazole, Fenticonazole, Isoconazole, Oxiconazole, Sertaconazole, Sulconazole, Thiabendazole, Tioconazole), triazoles (Fluconazole, Itraconazole, Ravuconazole, Posaconazole, Voriconazole), allylamines, Terbinafme, Amorolfine, Naftifine, Butenafme;

Flucytosine (antimetabolite), Griseofulvin, Caspofungin, Micafungin;

anti-pain agents such as paracetamol, codeine, dextropropoxyphene, tramadol, morphine and its derivatives, corticosteroids and derivatives;

anti-inflammatories such as glucocorticoids, nonsteroidal anti-inflammatory drugs, aspirin, ibuprofen, ketoprofen, flurbiprofen, diclofenac, aceclofenac, ketorolac, meloxicam, piroxicam, tenoxicam, Naproxen, Indomethacin, Naproxcinod, Nimesulide, Celecoxib, Etoricoxib, Parecoxib, Rofecoxib, Valdecoxib, Phenylbutazone, Niflumic acid, Mefenamic acid, Beta-18-glycyrrhetinic acid;

- the assets promoting healing such as Retinol, Vitamin A, Vitamin

E, N-acetyl-hydroxyproline, extracts of Centella Asiatica, papain, silicones, essential oils of thyme, niaouli, rosemary and sage, hyaluronic acid, synthetic polysulfated oligosaccharides having 1 to 4 units such as the potassium salt of octasulfated sucrose, the silver salt of octasulfated sucrose or sucralfate, antantoin, metformin;

- restructuring assets (for example rescutants of dander) such as silica derivatives, vitamin E, chamomile, calcium, horsetail extract, silk Lipester; anesthetics such as benzocaine, lidocaine, dibucaine, pramoxine hydrochloride, bupivacaine, mepivacaine, prilocaine and etidocaine.

haemostatics such as fibrinogen, factor XIII, fibronectin, thrombin, bovine aprotinin, tranexamic acid, collagen, aldehydes, cyanoacrylates, polyethylene glycol, alginates, cellulose, polysaccharides.

The other mechanical properties of the nonwoven will preferably be as follows.

The thickness of the nonwoven fabric is advantageously between 0.25 and 5 mm, preferably between 0.4 and 2.5 mm and very particularly between 0.5 and 1.5 mm. The thickness can be measured according to EN 9073-2.

The self-adhesion of the web according to the invention is achieved by the presence of many fibers in the partially free state on the surface of the nonwovens, the surface fibers becoming entangled with each other at the time of the superimposition of the web on it. -even. To obtain this self-adhesion property without altering the properties of tearability and extensibility, the number of crimped fibers, in particular in the form of a coil or a loop, on the surface of the nonwoven is advantageously greater than 10 crimped fibers / cm ^2. and preferably between 10 and 50 crimped fibers / cm ² . For the production of the dressing according to the invention, a number of crimped fibers on the nonwoven surface of between 10 and 35 crimped fibers / cm ^{2 will} be preferred.

The number of crimped fibers on the surface of the nonwoven can be determined as follows.

Take a picture (magnification × 100) of the surface of the nonwoven with the electron microscope, and count the number of crimped fibers (fibers making at least one round of spiral loop or coils formed on the surface of the nonwoven) , on a unit area of 1 cm ² of surface of imaged fibers. The measurement can be made in five arbitrary places, and the average number of looped fibers rounded to the nearest unit is calculated.

The self-adhesion characterization of the band is evaluated visually. A strip of nonwoven having a width of 15 mm is wound by stretching it slightly on the fingertip so as to form three turns and then torn manually. The self-gripping power is then estimated. It follows from this test that the bands remain on the finger for at least 30 minutes.

According to a variant of the present invention, it will be possible to add to the nonwoven one (or more) additional layer (s) chosen (s) from the textile materials, the materials alveolar, films, absorbent materials or their combinations. This additional layer makes it possible to improve, if necessary, the properties of the self-adhesive elastic band, for example by adapting its absorption, damping, conformability, rigidity or occlusivity capacities.

Among the materials, it will be possible to use materials based on synthetic or natural fibers. We can mention woven fabrics, nonwovens, knits, 3D knits, films, foams and their combinations.

The additional layer may optionally contain active agents that contribute to improving the healing of the wound or that can reduce the pain, or antibacterial agents. According to an alternative embodiment, it is possible to introduce into the additional layer antibacterial fibers, for example silver fibers, or to impregnate the latter with an antibacterial agent, for example triclosan.

The aerated structure and the presence of loops confer on the strip of the invention excellent damping and conformability properties.

Example: Dressing according to the invention

The example uses a nonwoven, based on two-component asymmetric crimped fibers, manufactured according to the teaching of the patent application WO 2008/015972. This nonwoven can be reference SR 0046 from Kuraray. This nonwoven is made from the side-by-side fiber, based on polyester copolymers of the company Kuraray whose reference is PN-780.

This nonwoven has the following properties and characteristics:

Nonwoven

Weight (EN 9073-1 standard) 90 g / m ²

Thickness (EN 9073-2 standard) 1.15 mm

Longitudinal elongation (EN 9073-3 standard) 98%

- Number of curly fibers

on the surface of non woven fabric * 19 / cm ²

* measured according to the method previously described 3. Performance of dressings

The performance of dressings consisting of a web of nonwoven according to the invention on the coagulation of blood was evaluated. Whole sheep blood was contacted with a nonwoven web according to the invention at a ratio of 1 cm ² / mL in test tubes incubated at 37 ± 1 ° C. A control tube without tape is tested under the same conditions as a negative control. After blood incorporation, the test tubes are gently inverted every minute until a blood clot is observed. The coagulation time is recorded for the article tested (4 trials). The average coagulation time of the sheep blood in the presence of the nonwoven according to the invention was 13 minutes thirty seconds. The mean clotting time of the sheep blood in the control test tube was about 26 minutes thirty seconds.

Claims

1 CLAIMS

1. Dressing comprising at least one strip consisting of a nonwoven of crimped fibers obtained from conjugated short fibers, in which

the nonwoven has a basis weight of between 10 g / m ² and 300 g / m ² ,

said fibers are uniformly crimped in the direction of the thickness of the nonwovens, and have an average radius of curvature of between 10 and 200 microns, and

the number of crimped fibers on the surface of each of the nonwovens is greater than 10 curled fibers / cm

for use in promoting and / or activating hemostasis

2. Dressing according to claim 1, characterized in that the conjugated short fibers are bicomponent, the two components constituting them being polymers which have a softening point greater than or equal to 100 ° C, said polymers being chosen from polypropylenic polymers, the polyester polymers and / or the polyamide polymers, and preferably are two different aromatic polyester polymers.

3. Dressing according to claim 2, characterized in that the bicomponent fibers have a side-by-side type structure and consist of a first polymer which is a polyethylene terephthalate, and a second polymer which is a copolymer of a alkylene arylate with isophthalic acid and / or diethylene glycol.

4. Dressing according to claim 1, characterized in that the average titer of the conjugated short fibers is between 1 and 5 dtex, preferably between 1.5 and 3 dtex, and the average length of the conjugated short fibers is between 10 to 100 mm, and preferably between 40 and 60 mm.

5. Dressing according to claim 1, characterized in that the crimped fibers have an average radius of curvature of between 50 and 160 microns, and preferably between 70 and 130 microns. 2

6. Dressing according to claim 1, characterized in that the nonwoven has a basis weight between 50 and 150 g / m ² and preferably between 70 and 110 g / m ² .

7. Dressing according to claim 1, characterized in that the number of crimped fibers on the surface of each of the nonwovens is between 10 and 50 crimped fibers / cm ² and preferably between 10 and 35 crimped fibers / cm ² .

8. Dressing according to claim 1, characterized in that the nonwoven has in a section taken in the direction of the thickness, a fiber curvature ratio greater than or equal to 1.3 in each of the areas delimited by a partition in three equal parts in the thickness direction, and the ratio of the minimum value to the maximum value of the fiber curl ratio in the various fields is greater than 75%.

9. Dressing according to claim 1, characterized in that it comprises an additional layer selected from textile materials, cellular materials, films or combinations thereof.

10. Dressing according to claim 1, characterized in that the band contains additives or active ingredients.