WO2017144065A1 - Sustainable and industrial production of guaianolides based on organ tissue culture - Google Patents

Sustainable and industrial production of guaianolides based on organ tissue culture Download PDF

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Publication number
WO2017144065A1
WO2017144065A1 PCT/DK2017/050049 DK2017050049W WO2017144065A1 WO 2017144065 A1 WO2017144065 A1 WO 2017144065A1 DK 2017050049 W DK2017050049 W DK 2017050049W WO 2017144065 A1 WO2017144065 A1 WO 2017144065A1
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WO
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Prior art keywords
basal medium
plant
mg
range
step
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PCT/DK2017/050049
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English (en)
French (fr)
Inventor
Henrik Toft SIMONSEN
Carmen Quinonero LOPEZ
Franck Michoux
Patricia CORRAL
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University Of Copenhagen
Ipalk Sas
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01HNEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H4/00Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
    • A01H4/005Methods for micropropagation; Vegetative plant propagation using cell or tissue culture techniques
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • C12N5/0025Culture media for plant cell or plant tissue culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/04Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
PCT/DK2017/050049 2016-02-26 2017-02-24 Sustainable and industrial production of guaianolides based on organ tissue culture WO2017144065A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DKPA201670113 2016-02-26
DKPA201670113 2016-02-26

Publications (1)

Publication Number Publication Date
WO2017144065A1 true true WO2017144065A1 (en) 2017-08-31

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Family Applications (1)

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PCT/DK2017/050049 WO2017144065A1 (en) 2016-02-26 2017-02-24 Sustainable and industrial production of guaianolides based on organ tissue culture

Country Status (1)

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WO (1) WO2017144065A1 (fi)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8772226B2 (en) 2009-03-17 2014-07-08 The Johns Hopkins University Methods and compositions for the detection of cancer
WO2015082978A1 (en) 2013-12-02 2015-06-11 Phyton Holdings, Llc Production of thapsigargins by thapsia cell suspension culture

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8772226B2 (en) 2009-03-17 2014-07-08 The Johns Hopkins University Methods and compositions for the detection of cancer
WO2015082978A1 (en) 2013-12-02 2015-06-11 Phyton Holdings, Llc Production of thapsigargins by thapsia cell suspension culture

Non-Patent Citations (26)

* Cited by examiner, † Cited by third party
Title
ANDERSEN, T.B. ET AL.: "Thapsigargin-From Thapsia L. to Mipsagargin", MOLECULES, vol. 20, no. 4, 2015, pages 6113 - 6127, XP055380863, DOI: doi:10.3390/molecules20046113
ANDREWS, S.P. ET AL.: "Design and total synthesis of unnatural analogues of the subnanomolar SERCA inhibitor thapsigargin", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 5, no. 9, 2007, pages 1427 - 1436
BALL, M. ET AL.: "Total synthesis of thapsigargin, a potent SERCA pump inhibitor", ORGANIC LETTERS, vol. 9, no. 4, 2007, pages 663 - 666
BHARAT SINGH ET AL: "Plant terpenes: defense responses, phylogenetic analysis, regulation and clinical applications", 3 BIOTECH, vol. 5, no. 2, 29 April 2014 (2014-04-29), DE, pages 129 - 151, XP055380608, ISSN: 2190-572X, DOI: 10.1007/s13205-014-0220-2 *
CHRISTENSEN, S.; A. ANDERSEN; U. SMITT: "Fortschritte der Chemie organischer Naturstoffe/Progress in the Chemistry of Organic Natural Products", 1997, SPRINGER, article "Sesquiterpenoids from Thapsia species and medicinal chemistry of the thapsigargins", pages: 129 - 167
CHU; SMITH; FELDING; BARAN: "Scalable Synthesis of (-)-Thapsigargin", ACS CENT SCI, vol. 3, no. 1, pages 47 - 51
DAMIAN PAUL DREW ET AL: "Guaianolides in apiaceae: perspectives on pharmacology and biosynthesis", PHYTOCHEMISTRY REVIEWS, KLUWER ACADEMIC PUBLISHERS, DO, vol. 8, no. 3, 19 May 2009 (2009-05-19), pages 581 - 599, XP019752726, ISSN: 1572-980X, DOI: 10.1007/S11101-009-9130-Z *
DATABASE PUBCHEM COMPOUND 1 June 2005 (2005-06-01), "Compound Summary for CID 446378: Thapsigargin", accession no. 46378
DATABASE PUBCHEM COMPOUND 28 April 2006 (2006-04-28), "Compound Summary for CID 6439396: AC1O5RL5", accession no. 439396
DOAN NHU THI QUYNH ET AL: "Targeting thapsigargin towards tumors", STEROIDS, vol. 97, 24 July 2014 (2014-07-24), pages 2 - 7, XP029150293, ISSN: 0039-128X, DOI: 10.1016/J.STEROIDS.2014.07.009 *
DOAN, N.T.Q. ET AL.: "Chemo-and Regioselective Functionalization of Nortrilobolide: Application for Semisynthesis of the Natural Product 2-Acetoxytrilobolide", JOURNAL OF NATURAL PRODUCTS, vol. 78, no. 6, 2015, pages 1406 - 1414, XP055213014, DOI: doi:10.1021/acs.jnatprod.5b00333
DOAN, N.T.Q. ET AL.: "Targeting thapsigargin towards tumors", STEROIDS, vol. 97, 2015, pages 2 - 7, XP029150293, DOI: doi:10.1016/j.steroids.2014.07.009
DREW, D.P. ET AL.: "Guaianolides in apiaceae: perspectives on pharmacology and biosynthesis", PHYTOCHEMISTRY REVIEWS, vol. 8, no. 3, 2009, pages 581 - 599, XP019752726, DOI: doi:10.1007/s11101-009-9130-z
DUCOS ET AL., IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - PLANT, vol. 43, 2007, pages 652 - 659
ETIENNE H ET AL: "Temporary immersion systems in plant micropropagation", PLANT CELL, TISSUE AND ORGAN CULTURE, SPRINGER, NL, vol. 69, no. 3, 1 June 2002 (2002-06-01), pages 215 - 231, XP002463450, ISSN: 0167-6857, DOI: 10.1023/A:1015668610465 *
ETIENNE; BERTHOULY, PLANT CELL, TISSUE AND ORGAN CULTURE, vol. 69, 2002, pages 215 - 231
HANHINEVA; KARENLAMPI, BMC BIOTECHNOLOGY, vol. 7, 2007, pages 11 - 23
JAGER, A.K. ET AL.: "Somatic embryogenesis in cell cultures of Thapsia garganica", PLANT CELL REPORTS, vol. 12, no. 9, 1993, pages 517 - 520, XP002737703
MAKUNGA, N.P.; A.K. JAGER; J. VAN STADEN: "An improved system for the in vitro regeneration of Thapsia garganica via direct organogenesis-influence of auxins and cytokinins", PLANT CELL, TISSUE AND ORGAN CULTURE, vol. 82, no. 3, 2005, pages 271 - 280, XP019268616
MAKUNGA, N.P.; A.K. JAGER; J. VAN STADEN: "Improved in vitro rooting and hyperhydricity in regenerating tissues of Thapsia garganica L", PLANT CELL, TISSUE AND ORGAN CULTURE, vol. 86, no. 1, 2006, pages 77 - 86, XP019409361, DOI: doi:10.1007/s11240-006-9100-8
MAKUNGA, N.P.; A.K. JAGER; J. VAN STADEN: "Micropropagation of Thapsia garganica--a medicinal plant", PLANT CELL REP, vol. 21, no. 10, 2003, pages 967 - 73, XP055178818, DOI: doi:10.1007/s00299-003-0623-8
NOKWANDA P MAKUNGA ET AL: "An improved system for the in vitro regeneration of Thapsia garganica via direct organogenesis - influence of auxins and cytokinins", PLANT CELL, TISSUE AND ORGAN CULTURE, KLUWER ACADEMIC PUBLISHERS, DO, vol. 82, no. 3, 1 September 2005 (2005-09-01), pages 271 - 280, XP019268616, ISSN: 1573-5044 *
NOKWANDA P MAKUNGA: "GENETIC TRANSFORMATION AND MICROPROPAGATION OF THAPSIA GARGANICA L.- A MEDICINAL PLANT", 1 November 2003 (2003-11-01), XP055380910, Retrieved from the Internet <URL:http://researchspace.ukzn.ac.za/xmlui/bitstream/ handle/10413/10057/Makunga _Nokwanda_P_2003.pdf? sequence=1> [retrieved on 20170613] *
OLLIVIER, A., J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI., vol. 926, 2013, pages 6 - 20
SMITT, U.W. ET AL.: "Comparative studies in phytochemistry and fruit anatomy of Thapsia garganica and T. transtagana, Apiaceae (Umbelliferae", BOTANICAL JOURNAL OF THE LINNEAN SOCIETY, vol. 117, no. 4, 1995, pages 281 - 292, XP009109771, DOI: doi:10.1006/bojl.1995.0019
TRINE BUNDGAARD ANDERSEN ET AL: "Thapsigargin-From Thapsia L. to Mipsagargin", MOLECULES, vol. 20, no. 4, 8 April 2015 (2015-04-08), pages 6113 - 6127, XP055380863, DOI: 10.3390/molecules20046113 *

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