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WO2017144065A1 - Sustainable and industrial production of guaianolides based on organ tissue culture - Google Patents

Sustainable and industrial production of guaianolides based on organ tissue culture Download PDF

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Publication number
WO2017144065A1
WO2017144065A1 PCT/DK2017/050049 DK2017050049W WO2017144065A1 WO 2017144065 A1 WO2017144065 A1 WO 2017144065A1 DK 2017050049 W DK2017050049 W DK 2017050049W WO 2017144065 A1 WO2017144065 A1 WO 2017144065A1
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WO
WIPO (PCT)
Prior art keywords
basal medium
plant
mg
range
step
Prior art date
Application number
PCT/DK2017/050049
Other languages
English (en)
French (fr)
Inventor
Henrik Toft SIMONSEN
Carmen Quinonero LOPEZ
Franck Michoux
Patricia CORRAL
Original Assignee
University Of Copenhagen
Ipalk Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DKPA201670113 priority Critical
Priority to DKPA201670113 priority
Application filed by University Of Copenhagen, Ipalk Sas filed Critical University Of Copenhagen
Publication of WO2017144065A1 publication Critical patent/WO2017144065A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01HNEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H4/00Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
    • A01H4/005Methods for micropropagation; Vegetative plant propagation using cell or tissue culture techniques
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • C12N5/0025Culture media for plant cell or plant tissue culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/04Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
PCT/DK2017/050049 2016-02-26 2017-02-24 Sustainable and industrial production of guaianolides based on organ tissue culture WO2017144065A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DKPA201670113 2016-02-26
DKPA201670113 2016-02-26

Publications (1)

Publication Number Publication Date
WO2017144065A1 true WO2017144065A1 (en) 2017-08-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2017/050049 WO2017144065A1 (en) 2016-02-26 2017-02-24 Sustainable and industrial production of guaianolides based on organ tissue culture

Country Status (1)

Country Link
WO (1) WO2017144065A1 (fi)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8772226B2 (en) 2009-03-17 2014-07-08 The Johns Hopkins University Methods and compositions for the detection of cancer
WO2015082978A1 (en) 2013-12-02 2015-06-11 Phyton Holdings, Llc Production of thapsigargins by thapsia cell suspension culture

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8772226B2 (en) 2009-03-17 2014-07-08 The Johns Hopkins University Methods and compositions for the detection of cancer
WO2015082978A1 (en) 2013-12-02 2015-06-11 Phyton Holdings, Llc Production of thapsigargins by thapsia cell suspension culture

Non-Patent Citations (26)

* Cited by examiner, † Cited by third party
Title
ANDERSEN, T.B. ET AL.: "Thapsigargin-From Thapsia L. to Mipsagargin", MOLECULES, vol. 20, no. 4, 2015, pages 6113 - 6127, XP055380863, DOI: doi:10.3390/molecules20046113
ANDREWS, S.P. ET AL.: "Design and total synthesis of unnatural analogues of the subnanomolar SERCA inhibitor thapsigargin", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 5, no. 9, 2007, pages 1427 - 1436
BALL, M. ET AL.: "Total synthesis of thapsigargin, a potent SERCA pump inhibitor", ORGANIC LETTERS, vol. 9, no. 4, 2007, pages 663 - 666
BHARAT SINGH ET AL: "Plant terpenes: defense responses, phylogenetic analysis, regulation and clinical applications", 3 BIOTECH, vol. 5, no. 2, 29 April 2014 (2014-04-29), DE, pages 129 - 151, XP055380608, ISSN: 2190-572X, DOI: 10.1007/s13205-014-0220-2 *
CHRISTENSEN, S.; A. ANDERSEN; U. SMITT: "Fortschritte der Chemie organischer Naturstoffe/Progress in the Chemistry of Organic Natural Products", 1997, SPRINGER, article "Sesquiterpenoids from Thapsia species and medicinal chemistry of the thapsigargins", pages: 129 - 167
CHU; SMITH; FELDING; BARAN: "Scalable Synthesis of (-)-Thapsigargin", ACS CENT SCI, vol. 3, no. 1, pages 47 - 51
DAMIAN PAUL DREW ET AL: "Guaianolides in apiaceae: perspectives on pharmacology and biosynthesis", PHYTOCHEMISTRY REVIEWS, KLUWER ACADEMIC PUBLISHERS, DO, vol. 8, no. 3, 19 May 2009 (2009-05-19), pages 581 - 599, XP019752726, ISSN: 1572-980X, DOI: 10.1007/S11101-009-9130-Z *
DATABASE PUBCHEM COMPOUND 1 June 2005 (2005-06-01), "Compound Summary for CID 446378: Thapsigargin", accession no. 46378
DATABASE PUBCHEM COMPOUND 28 April 2006 (2006-04-28), "Compound Summary for CID 6439396: AC1O5RL5", accession no. 439396
DOAN NHU THI QUYNH ET AL: "Targeting thapsigargin towards tumors", STEROIDS, vol. 97, 24 July 2014 (2014-07-24), pages 2 - 7, XP029150293, ISSN: 0039-128X, DOI: 10.1016/J.STEROIDS.2014.07.009 *
DOAN, N.T.Q. ET AL.: "Chemo-and Regioselective Functionalization of Nortrilobolide: Application for Semisynthesis of the Natural Product 2-Acetoxytrilobolide", JOURNAL OF NATURAL PRODUCTS, vol. 78, no. 6, 2015, pages 1406 - 1414, XP055213014, DOI: doi:10.1021/acs.jnatprod.5b00333
DOAN, N.T.Q. ET AL.: "Targeting thapsigargin towards tumors", STEROIDS, vol. 97, 2015, pages 2 - 7, XP029150293, DOI: doi:10.1016/j.steroids.2014.07.009
DREW, D.P. ET AL.: "Guaianolides in apiaceae: perspectives on pharmacology and biosynthesis", PHYTOCHEMISTRY REVIEWS, vol. 8, no. 3, 2009, pages 581 - 599, XP019752726, DOI: doi:10.1007/s11101-009-9130-z
DUCOS ET AL., IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - PLANT, vol. 43, 2007, pages 652 - 659
ETIENNE H ET AL: "Temporary immersion systems in plant micropropagation", PLANT CELL, TISSUE AND ORGAN CULTURE, SPRINGER, NL, vol. 69, no. 3, 1 June 2002 (2002-06-01), pages 215 - 231, XP002463450, ISSN: 0167-6857, DOI: 10.1023/A:1015668610465 *
ETIENNE; BERTHOULY, PLANT CELL, TISSUE AND ORGAN CULTURE, vol. 69, 2002, pages 215 - 231
HANHINEVA; KARENLAMPI, BMC BIOTECHNOLOGY, vol. 7, 2007, pages 11 - 23
JAGER, A.K. ET AL.: "Somatic embryogenesis in cell cultures of Thapsia garganica", PLANT CELL REPORTS, vol. 12, no. 9, 1993, pages 517 - 520, XP002737703
MAKUNGA, N.P.; A.K. JAGER; J. VAN STADEN: "An improved system for the in vitro regeneration of Thapsia garganica via direct organogenesis-influence of auxins and cytokinins", PLANT CELL, TISSUE AND ORGAN CULTURE, vol. 82, no. 3, 2005, pages 271 - 280, XP019268616
MAKUNGA, N.P.; A.K. JAGER; J. VAN STADEN: "Improved in vitro rooting and hyperhydricity in regenerating tissues of Thapsia garganica L", PLANT CELL, TISSUE AND ORGAN CULTURE, vol. 86, no. 1, 2006, pages 77 - 86, XP019409361, DOI: doi:10.1007/s11240-006-9100-8
MAKUNGA, N.P.; A.K. JAGER; J. VAN STADEN: "Micropropagation of Thapsia garganica--a medicinal plant", PLANT CELL REP, vol. 21, no. 10, 2003, pages 967 - 73, XP055178818, DOI: doi:10.1007/s00299-003-0623-8
NOKWANDA P MAKUNGA ET AL: "An improved system for the in vitro regeneration of Thapsia garganica via direct organogenesis - influence of auxins and cytokinins", PLANT CELL, TISSUE AND ORGAN CULTURE, KLUWER ACADEMIC PUBLISHERS, DO, vol. 82, no. 3, 1 September 2005 (2005-09-01), pages 271 - 280, XP019268616, ISSN: 1573-5044 *
NOKWANDA P MAKUNGA: "GENETIC TRANSFORMATION AND MICROPROPAGATION OF THAPSIA GARGANICA L.- A MEDICINAL PLANT", 1 November 2003 (2003-11-01), XP055380910, Retrieved from the Internet <URL:http://researchspace.ukzn.ac.za/xmlui/bitstream/ handle/10413/10057/Makunga _Nokwanda_P_2003.pdf? sequence=1> [retrieved on 20170613] *
OLLIVIER, A., J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI., vol. 926, 2013, pages 6 - 20
SMITT, U.W. ET AL.: "Comparative studies in phytochemistry and fruit anatomy of Thapsia garganica and T. transtagana, Apiaceae (Umbelliferae", BOTANICAL JOURNAL OF THE LINNEAN SOCIETY, vol. 117, no. 4, 1995, pages 281 - 292, XP009109771, DOI: doi:10.1006/bojl.1995.0019
TRINE BUNDGAARD ANDERSEN ET AL: "Thapsigargin-From Thapsia L. to Mipsagargin", MOLECULES, vol. 20, no. 4, 8 April 2015 (2015-04-08), pages 6113 - 6127, XP055380863, DOI: 10.3390/molecules20046113 *

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