WO2017134146A9 - Gpbp inhibitors and uses and scaleable synthesis thereof - Google Patents
Gpbp inhibitors and uses and scaleable synthesis thereof Download PDFInfo
- Publication number
- WO2017134146A9 WO2017134146A9 PCT/EP2017/052220 EP2017052220W WO2017134146A9 WO 2017134146 A9 WO2017134146 A9 WO 2017134146A9 EP 2017052220 W EP2017052220 W EP 2017052220W WO 2017134146 A9 WO2017134146 A9 WO 2017134146A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compounds
- emt
- gpbp inhibitors
- scaleable synthesis
- scaleable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/74—Unsaturated compounds containing —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
Abstract
The present invention provides compounds and compositions thereof that inhibit Goodpasture antigen binding protein. Also disclosed is use of the compounds for the treatment various diseases and disorders, including invasive tumors, for the inhibition of mesenchymal phenotype after epithelial-to- mesenchymal transition (EMT), and for detecting EMT in a tissue. A method of preparing the compounds of the invention and related compounds is also provided.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662290238P | 2016-02-02 | 2016-02-02 | |
US62/290,238 | 2016-02-02 | ||
US201662310395P | 2016-03-18 | 2016-03-18 | |
US62/310,395 | 2016-03-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2017134146A1 WO2017134146A1 (en) | 2017-08-10 |
WO2017134146A9 true WO2017134146A9 (en) | 2019-06-20 |
Family
ID=57984925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2017/052220 WO2017134146A1 (en) | 2016-02-02 | 2017-02-02 | Gpbp inhibitors and uses and scaleable synthesis thereof |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2017134146A1 (en) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8586776B2 (en) * | 2009-11-05 | 2013-11-19 | Fibrostatin, S.L. | GPBP inhibition using Q2 peptidomimetics |
JP2015524385A (en) * | 2012-07-02 | 2015-08-24 | フィブロスタティン,エス.エル. | GPBP-1 inhibition and therapeutic use thereof |
-
2017
- 2017-02-02 WO PCT/EP2017/052220 patent/WO2017134146A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2017134146A1 (en) | 2017-08-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SA519401020B1 (en) | N-(phenylsulfonyl)benzamides and related compounds as b-cell lymphoma-2 protein inhibitors | |
MX2018015853A (en) | Multispecific antibodies against cd40 and cd137. | |
MX2014000518A (en) | Inhibitors of bruton's tyrosine kinase. | |
MX2017016655A (en) | Ophthalmic formulations of tyrosine kinase inhibitors, methods of use thereof, and preparation methods thereof. | |
WO2010009342A3 (en) | Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors | |
EA033689B9 (en) | Inhibitors of kras g12c | |
TW201613644A (en) | Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor, and/or a JAK-2 inhibitor | |
PH12015501868A1 (en) | Inhibitors of histone demethylases | |
PH12015502792A1 (en) | Crystalline bromodomain inhibitors | |
MX2017001656A (en) | Bruton's tyrosine kinase inhibitor combinations and uses thereof. | |
NZ764151A (en) | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof | |
MX2019009501A (en) | Amino pyrimidine compounds useful as ssao inhibitors. | |
EP2576549A4 (en) | Bicyclic heteroaryl kinase inhibitors and methods of use | |
MX2012004258A (en) | Inhibitors of bruton's tyrosine kinase. | |
MX2018011102A (en) | Combinations of lsd1 inhibitors for use in the treatment of solid tumors. | |
WO2010068483A3 (en) | Mlk inhibitors and methods of use | |
EP3873905A4 (en) | Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use as atr kinase inhibitors | |
EA201790085A1 (en) | INHIBITORS OF LYSINE-SPECIFIC DEMETILASE-1 | |
MX336051B (en) | Diarylacetylene hydrazide containing tyrosine kinase inhibitors. | |
WO2016109217A3 (en) | Btk inhibitors | |
TW201625535A (en) | Inhibitors of histone demethylases | |
PH12016502353A1 (en) | Pharmaceutical composition | |
TW201613577A (en) | Pharmaceutical combinations | |
EP2563794A4 (en) | Inhibitors of protein tyrosine kinase activity and use thereof to treat ophthalmic disorders | |
MX2017003466A (en) | Histone demethylase inhibitors. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 17703712 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase in: |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 17703712 Country of ref document: EP Kind code of ref document: A1 |