WO2017124016A3 - Compositions and methods for internalizing pro-labeled molecules into targeted cells and transforming them in situ into labeled molecules - Google Patents
Compositions and methods for internalizing pro-labeled molecules into targeted cells and transforming them in situ into labeled molecules Download PDFInfo
- Publication number
- WO2017124016A3 WO2017124016A3 PCT/US2017/013531 US2017013531W WO2017124016A3 WO 2017124016 A3 WO2017124016 A3 WO 2017124016A3 US 2017013531 W US2017013531 W US 2017013531W WO 2017124016 A3 WO2017124016 A3 WO 2017124016A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- labeled molecules
- compositions
- methods
- internalizing
- transforming
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000011065 in-situ storage Methods 0.000 title 1
- 230000001131 transforming effect Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
- A61K49/0043—Fluorescein, used in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
- C09B11/10—Amino derivatives of triarylmethanes
- C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Disclosed are compositions and methods for assessing the presence of target cell, such as tumor cells amongst normal cells.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/655,664 US20180036312A1 (en) | 2016-08-02 | 2017-07-20 | Novel Scaffolds for Intracellular Compound Delivery for the Detection of Cancer Cells |
PCT/US2017/043141 WO2018026538A1 (en) | 2016-08-02 | 2017-07-20 | Novel scaffolds for intracellular compound delivery for the detection of cancer cells |
EP17837395.7A EP3493851A4 (en) | 2016-08-02 | 2017-07-20 | Novel scaffolds for intracellular compound delivery for the detection of cancer cells |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662279596P | 2016-01-15 | 2016-01-15 | |
US62/279,596 | 2016-01-15 | ||
US15/042,103 | 2016-02-11 | ||
US15/042,103 US20170234878A1 (en) | 2016-02-11 | 2016-02-11 | Compositions for detecting cancer cells on a cellular surface |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/595,920 Continuation-In-Part US10239891B2 (en) | 2016-08-02 | 2017-05-15 | Compositions to detect remnant cancer cells |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2017124016A2 WO2017124016A2 (en) | 2017-07-20 |
WO2017124016A3 true WO2017124016A3 (en) | 2017-10-12 |
Family
ID=59311484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2017/013531 WO2017124016A2 (en) | 2016-01-15 | 2017-01-13 | Compositions and methods for internalizing pro-labeled molecules into targeted cells and transforming them in situ into labeled molecules |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2017124016A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3493851A4 (en) * | 2016-08-02 | 2020-06-24 | ISI Life Sciences, Inc. | Novel scaffolds for intracellular compound delivery for the detection of cancer cells |
WO2018026965A1 (en) * | 2016-08-02 | 2018-02-08 | Isi Life Sciences, Inc. | Compositions and methods for detecting cancer cells in a tissue sample |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6455268B1 (en) * | 1999-11-05 | 2002-09-24 | Iconix Pharmaceuticals Inc. | Hydrolytic enzyme substrates and assay method |
US6875850B2 (en) * | 2000-09-08 | 2005-04-05 | Roche Diagnostics Operations, Inc. | Reagent for labelling nucleic acids |
US20130344002A1 (en) * | 2002-02-07 | 2013-12-26 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
US20140005141A1 (en) * | 2006-03-07 | 2014-01-02 | Bio-Technology General (Israel) Ltd. | Hydrazido derivatives of hyaluronic acid |
US20140227297A1 (en) * | 2013-02-08 | 2014-08-14 | The Regents Of The University Of Michigan | Targeted theranostics |
US20150057433A1 (en) * | 2012-03-26 | 2015-02-26 | The Regents Of The University Of California | Preparation of functionalized polypeptides, peptides, and proteins by alkylation of thioether groups |
-
2017
- 2017-01-13 WO PCT/US2017/013531 patent/WO2017124016A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6455268B1 (en) * | 1999-11-05 | 2002-09-24 | Iconix Pharmaceuticals Inc. | Hydrolytic enzyme substrates and assay method |
US6875850B2 (en) * | 2000-09-08 | 2005-04-05 | Roche Diagnostics Operations, Inc. | Reagent for labelling nucleic acids |
US20130344002A1 (en) * | 2002-02-07 | 2013-12-26 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
US20140005141A1 (en) * | 2006-03-07 | 2014-01-02 | Bio-Technology General (Israel) Ltd. | Hydrazido derivatives of hyaluronic acid |
US20150057433A1 (en) * | 2012-03-26 | 2015-02-26 | The Regents Of The University Of California | Preparation of functionalized polypeptides, peptides, and proteins by alkylation of thioether groups |
US20140227297A1 (en) * | 2013-02-08 | 2014-08-14 | The Regents Of The University Of Michigan | Targeted theranostics |
Non-Patent Citations (7)
Title |
---|
ABBASI ET AL.: "Cationic Albumin Nanoparticles for Enhanced Drug Delivery to Treat Breast Cancer: Preparation and In Vitro Assessment", JOURNAL OF DRUG DELIVER Y, 2012, pages 1 - 8, XP055436901 * |
DATABASE Pubchem [O] 18 December 2015 (2015-12-18), XP055437010, Database accession no. 101839416 * |
DATABASE Pubchem [O] 26 December 2015 (2015-12-26), XP055436903, Database accession no. 102433897 * |
DATABASE Pubchem [O] 8 August 2005 (2005-08-08), XP055437009, Database accession no. 81743 * |
OGAWA ET AL.: "Fluorophore-Quencher Based Activatable Targeted Optical Probes for Detecting in Vivo Cancer Metastases", MOLECULAR PHARACEUTICS., vol. 6, 21 January 2009 (2009-01-21), pages 386 - 395, XP055320621 * |
ROELANTS ET AL.: "Use of fluorescein isothiocyanate-human serum albumin for the intravesical photodiagnosis of non-muscle-invasive bladder cancer: an in vitro study using multicellular spheroids composed of normal human urothelial and urothelial cell carcinoma cell lines", BJU INTERNATIONAL, vol. 108, 13 December 2010 (2010-12-13), pages 455 - 459, XP055436893 * |
URANO ET AL.: "Evolution of Fluorescein as a Platform for Finely Tunable Fluorescence Probes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, 10 March 2005 (2005-03-10), pages 4888 - 4894, XP002481573 * |
Also Published As
Publication number | Publication date |
---|---|
WO2017124016A2 (en) | 2017-07-20 |
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