WO2017109735A1 - Santé buccale pour animaux de compagnie - Google Patents

Santé buccale pour animaux de compagnie Download PDF

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Publication number
WO2017109735A1
WO2017109735A1 PCT/IB2016/057898 IB2016057898W WO2017109735A1 WO 2017109735 A1 WO2017109735 A1 WO 2017109735A1 IB 2016057898 W IB2016057898 W IB 2016057898W WO 2017109735 A1 WO2017109735 A1 WO 2017109735A1
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WO
WIPO (PCT)
Prior art keywords
animal
composition
lactobacillus paracasei
oral health
food
Prior art date
Application number
PCT/IB2016/057898
Other languages
English (en)
Inventor
Julie K SPEARS
Arleigh J Reynolds
George Arthur WELLS
Delphine Tissot-Favre
Original Assignee
Nestec Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of WO2017109735A1 publication Critical patent/WO2017109735A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/92—Oral administration

Definitions

  • This invention relates generally to the oral health for . companion animals.
  • the present invention relates to methods for improving oral health by treating, preventing or improving oral health conditions including plaque, malodor, bacteria, and tooth shade in a companion animal.
  • compositions and methods to promote or improve oral health care for a companion animal there remains a need for compositions and methods to promote or improve oral health care for a companion animal.
  • a method for improving oral health in a companion animal can comprise identifying a companion animal that is suffering from an oral health condition and administering a composition comprising non-replicating Lactobacillus paracasei to the companion animal. Generally, the composition is administered in an amount effective for treating the oral health condition in the animal.
  • the term "companion animal” refers to any domesticated animal, and includes, without limitation, cats, dogs, rabbits, guinea pigs, ferrets, hamsters, mice, gerbils, horses, cows, goats, sheep, donkeys, pigs, and the like.
  • the companion animal can be a dog or cat.
  • RDA Recommended daily requirement
  • IOM Institute of Medicine of the National Academys
  • DAI Dietary Reference Intake
  • FEDIAF European Pet Food Industry Federation
  • AAFCO Association of American Feed control Officials
  • aging means being of advanced age such that the animal has exceeded 50% of the average lifespan for its particular species and/or breed within a species. For example, if the average lifespan for a given breed of dog is 10 years, then a dog within that breed greater than 5 years old would be considered “aging” for purposes herein.
  • Healthy aging animals are those with no known diseases that might confound the results. In studies using healthy aging animals, cohort animals are also healthy aging animals,
  • long-term administration means periods of repeated administration or consumption in excess of one month. Periods of longer than two, three, or four can be used for certain embodiments. Also, more extended periods that include longer than 5, 6, 7, 8, 9, or 10 months can be used. Periods in excess of 11 months or 1 year can also be used. Longer term use extending over 1, 2, 3, or more years can also be included in the invention. For certain aging animals, the animal will continue consuming on a regular basis for the remainder of its life. Sometimes this is referred to as consumption for "extended" periods.
  • the term "regular basis” means at least monthly dosing with the compositions or consumption of the compositions, and in some aspects, weekly dosing. More frequent dosing or consumption, such as twice, three, or seven times weekly, can be used in certain embodiments. Still other embodiments include regimens that comprise at least once daily consumption. The skilled artisan will appreciate that dosing frequency will be a function of the composition that is being consumed or administered, and some compositions may require more or less frequent administration to maintain a desired level of oral health.
  • the term "individual" when referring to an animal means an individual animal of any species or kind.
  • ranges are used herein in shorthand, so as to avoid having to set out at length and describe each and every value within the range. Any appropriate value within the range can be selected, where appropriate, as the upper value, lower value, or the terminus of the range.
  • references “a”, “an”, and “the” are generally inclusive of the plurals of the respective terms.
  • reference to “a dog” or “a method” includes a plurality of such “dogs” or “methods”.
  • Reference herein, for example to “a probiotic” includes a plurality of such probiotics, whereas reference to “B vitamins” includes a single B vitamin.
  • the words “comprise”, “comprises”, and “comprising” are to be interpreted inclusively rather than exclusively.
  • compositions can provide an oral health benefit to a companion animal.
  • the inventors have discovered that the oral cavity of companion animals differ in bacteria and pH than that of humans and that certain non-replicating Lactobacillus paracasei can provide improved oral health in companion animals.
  • the cell walls of the non-replicating Lactobacillus paracasei can bind to the oral microbiota found in companion animals.
  • Lactobacillus paracasei can adhere to and remove pathogenic bacteria such as Streptococcus mutans in the oral cavity of humans
  • the present inventors have discovered that dogs and cats do not have oral Streptococcus mutans and they do not get dental caries.
  • 454 pyrosequencing analysis of dog plaque microbiota receiving a control diet show only 2 Streptococcus species identified (S. minor and S.
  • the Streptococcus genus comprises less than 1% of identified operational taxonomic units (OTUs) in the cat and dog (0.45% of the cat and 0.11% of the dog in V123; 0.05% of the cat and 0.1% of the dog in V456).
  • OTUs operational taxonomic units
  • a method for improving oral health in a companion animal can comprise identifying a companion animal that is suffering from an oral health condition and administering a composition comprising non-replicating Lactobacillus paracasei to the companion animal. Generally, the composition is administered in an amount effective for treating the oral health condition in the animal.
  • oral health conditions can include, without limitation, dental plaque, periodontal infection, breath malodor, porphyrin-producing bacteria, and tooth shade.
  • non-replicating Lactobacillus paracasei can include any strain that has been heat treated such that substantially all of the bacteria are inactive. In one embodiment, at least 90% of the bacteria can be inactive. In other aspects, at least 95% of the bacteria can be inactive, at least 99% of the bacteria can be inactive, or even, at least 99.9% can be inactive. In one embodiment, the Lactobacillus paracasei can be Lactobacillus paracasei DSM 16671 (including those commercially available from BASF (PRO-T-ACTION®) or GenMont Biotech Inc. (ADP-1)).
  • the non-replicating Lactobacillus paracasei can be administered as a composition to the companion animal in an amount effective for promoting, treating, or improving a health condition in the companion animal as discussed herein.
  • the non-replicating Lactobacillus paracasei can be administered in an amount of 0.1 mg to 50 mg per day to the companion animal.
  • the non-replicating Lactobacillus paracasei can be administered in an amount of 1 mg to 10 mg per day to the companion animal.
  • NRMs can be administered to the animal in amounts of from about one to about twenty billion colony forming units (CFUs) per day for a companion animal, and in one aspect, from about 10 million to about 10 billion NRMs per day.
  • CFUs colony forming units
  • the non-replicating Lactobacillus paracasei can be administered in an amount ranging from 10 8 cfu/day to 10 10 cfu/day to the companion animal.
  • Such compositions include any composition that can deliver non-replicating Lactobacillus paracasei.
  • the composition can be a pet food composition.
  • the composition can be a supplement.
  • the composition can be delivered via a sachet.
  • the composition can further comprises a member selected from the group consisting of vitamin, antioxidant, probiotic, prebiotic, and mixtures thereof.
  • the compositions further comprise prebiotics, probiotics, or a combination thereof.
  • Probiotics are live microorganisms that have a beneficial effect in the prevention and treatment of specific medical conditions when ingested. Probiotics are believed to exert biological effects through a phenomenon known as colonization resistance. The probiotics facilitate a process whereby the indigenous anaerobic flora limits the concentration of potentially harmful (mostly aerobic) bacteria in the digestive tract. Other modes of action, such as supplying enzymes or influencing enzyme activity in the gastrointestinal tract, may also account for some of the other functions that have been attributed to probiotics.
  • Prebiotics are nondigestible food ingredients that beneficially affect host health by selectively stimulating the growth and/or activity of bacteria in the colon.
  • Prebiotics include fructooligosaccharides (FOS), xylooligosaccharides (XOS), galactooligosaccharides (GOS), and mannooligosaccharides (typically for non-human foods such as petfoods).
  • FOS fructooligosaccharide
  • XOS xylooligosaccharides
  • GOS galactooligosaccharides
  • mannooligosaccharides typically for non-human foods such as petfoods.
  • the prebiotic, fructooligosaccharide (FOS) can be found naturally in many foods such as wheat, onions, bananas, honey, garlic, and leeks.
  • FOS can also be isolated from chicory root or synthesized enzymatically from sucrose.
  • FOS fermentation in the colon results in a large number of physiologic effects including increasing the numbers of bifidobacteria in the colon, increasing calcium absorption, increasing fecal weight, shortening of gastrointestinal transit time, and possibly lowering blood lipid levels.
  • the increase in bifidobacteria has been assumed to benefit animal health by producing compounds to inhibit potential pathogens, by reducing blood ammonia levels, and by producing vitamins and digestive enzymes.
  • Probiotic bacteria such as Lactobacilli or Bifidobacteria are believed to positively affect the immune response by improving the intestinal microbial balance leading to enhanced antibody production and phagocytic (devouring or killing) activity of white blood cells.
  • Bifidobacterium lactis could be an effective probiotic dietary supplement for enhancing some aspects of cellular immunity in the elderly.
  • Probiotics enhance systemic cellular immune responses and may be useful as a dietary supplement to boost natural immunity in otherwise healthy adults.
  • Probiotics include many types of bacteria but generally are selected from four genera of bacteria: Lactobacillus acidophilus, Bifidobacteria, Lactococcus, and Pediococcus.
  • Beneficial species include Enterococcus and Saccharomyces species.
  • probiotics and prebiotics to be administered to the animal is determined by the skilled artisan based upon the type and nature of the prebiotic and probiotic and the type and nature of the animal, e.g., the age, weight, general health, sex, extent of microbial depletion, presence of harmful bacteria, and diet of the animal.
  • probiotics are administered to the animal in amounts of from about one to about twenty billion colony forming units (CFUs) per day for the healthy maintenance of intestinal microflora, preferably from about 5 billion to about 10 billion live bacteria per day.
  • prebiotics are administered in amounts sufficient to positively stimulate the healthy microflora in the gut and cause these "good" bacteria to reproduce.
  • compositions may further comprise substances such as minerals, vitamins, salts, nutrients, functional additives including, for example, palatants, colorants, emulsifiers, antimicrobial or other preservatives.
  • Minerals that may be useful in such compositions include, for example, calcium, phosphorous, potassium, sodium, iron, chloride, boron, copper, zinc, magnesium, manganese, iodine, selenium and the like.
  • additional vitamins useful herein include vitamin B and such fat soluble vitamins as D and K.
  • Inulin, amino acids, taurine, choline, enzymes, coenzymes, and the like may be useful to include in various embodiments.
  • the B vitamins can be any B vitamin suitable for administration to an animal.
  • B vitamins include vitamin Bl (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin, nicotinic acid, nicotinamide), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine, pyridoxal, pyridoxamine), vitamin B7 (biotin), vitamin B8 (myo-inositol), vitamin B9 (folic acid) vitamin B 12 (cobalamin compounds including methylcobalamin, hydroxocobalamin, and
  • cyanocobalamin or salts, conjugates, or derivatives thereof recognized of found to have B vitamin activity. Combinations of any of the foregoing are also useful herein and are sometimes referred to herein as "mixtures" of B vitamins.
  • the antioxidants can be any antioxidant suitable for administration to an animal.
  • Antioxidants are well known in the art, particularly the art of food technology and food formulation.
  • Natural antioxidant compounds include vitamins (such as A, C and E, and derivative, conjugates, or analogs thereof), as well as plant extracts, including extracts from fruit, vegetables, herbs, seeds, and other types and/or parts of plants.
  • ubiquinols e.g., coenzyme Q10
  • carotenoids e.g., beta-carotene, alpha-carotene, beta-cryptoxanthin, gamma-carotene, lutein, astaxanthin, and zeaxanthin etc.
  • flavonoids e.g., flavonoids, phenolic acids and polyphenols, and pycnogenol
  • plant sources of antioxidants include those from fruits such as berries (cherry, blackberry, strawberry, raspberry, crowberry, blueberry, bilberry/wild blueberry, black currant), pomegranate, grape, orange, plum, pineapple, kiwi fruit, and grapefruit; those from vegetables including kale, chili pepper, red cabbage, peppers, parsley, artichoke, Brussels sprouts, spinach, lemon, ginger, garlic, and red beets; those from dry fruits like apricots, prunes, and dates; from legumes including broad beans, pinto beans, and soybeans.
  • nuts and seeds such as pecans, walnuts, hazelnuts, ground nut, and sunflower seeds; cereals such as barley, millet, oats, and corn.
  • Many natural antioxidants are also available from a wide variety of spices including cloves, cinnamon, rosemary, and oregano. Less widely known sources of antioxidants include Ginkgo biloba, and tropical plants such as uyaku, and carica papaya. Antioxidant properties of various teas and green tea, as well as fermented products such as red wine, have become of great interest in recent years and such would be suitable for use herein.
  • Selenium is an excellent oxygen scavenger and works well, especially with vitamin or related tocopherol compounds.
  • Synthetic dietary antioxidants include butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) which are commonly used in food products. Any of the foregoing, alone or in combination, are suited for use herein, as are combinations of natural and synthetic antioxidants.
  • the antioxidants comprise astaxanthin alone or in combination with other antioxidants.
  • the composition comprises from about 0.1 to 40 times the recommended daily requirement (RDA) of minerals and vitamins and from about 0.0001% to about 25% of antioxidants.
  • RDA recommended daily requirement
  • the minerals and vitamins comprise from about 0.1 to 20 times the RDA, and in one aspect, from about 0.1 to 10 times the RDA
  • antioxidants comprise from about 0.0001% to about 15%, in one aspect, from about 0.001% to about 5%, and in one specific aspect, from about 0.001% to about 2%.
  • the compositions can be pet food compositions.
  • Such compositions include foods intended to supply the necessary dietary requirements for an animal, animal treats ⁇ e.g., biscuits), or dietary supplements.
  • the compositions may be a dry composition (e.g., kibble), semi-moist composition, wet composition, or any mixture thereof.
  • the composition is a dietary supplement such as a gravy, drinking water, beverage, yogurt, powder, granule, paste, suspension, chew, morsel, treat, snack, pellet, pill, capsule, tablet, or any other suitable delivery form.
  • the dietary supplement can comprise a high concentration of the non-replicating Lactobacillus paracasei, probiotics, prebiotics, minerals, vitamins and/or antioxidants. This permits the supplement to be administered to the animal in small amounts, or in the alternative, can be diluted before administration to an animal.
  • the dietary supplement may require admixing, or can be admixed with water or other diluent prior to administration to the animal.
  • the compositions can be refrigerated or frozen compositions.
  • the non-replicating Lactobacillus paracasei can be pre-blended with the other components to provide the beneficial amounts needed.
  • the non- replicating Lactobacillus paracasei can be used to coat a food, snack, pet food composition, or pet treat.
  • the non-replicating Lactobacillus paracasei can be added to the composition just prior to offering it to the animal, e.g., using a sprinkled powder or a mix.
  • Such compositions further comprise probiotics, prebiotics, minerals, vitamins and/or antioxidants.
  • the compositions can optionally comprise one or more supplementary substances that promote or sustain general health. Preferred substances may be associated with improved oral health or may be substances that promote oral health care.
  • pet food or pet treat compositions can comprise from about 15% to about 50% crude protein.
  • the crude protein material may comprise vegetable proteins such as soybean meal, soy protein concentrate, corn gluten meal, wheat gluten, cottonseed, and peanut meal, or animal proteins such as casein, albumin, and meat protein.
  • meat protein useful herein include pork, lamb, equine, poultry, fish, and mixtures thereof.
  • compositions may further comprise from about 5% to about 40% fat.
  • the compositions may further comprise a source of carbohydrate.
  • the compositions may comprise from about 15% to about 60% carbohydrate.
  • examples of such carbohydrates include grains or cereals such as rice, corn, milo, sorghum, alfalfa, barley, soybeans, canola, oats, wheat, and mixtures thereof.
  • the compositions may also optionally comprise other materials such as dried whey and other daily by-products.
  • the ash content of the composition ranges from less than 1% to about 15%, and in one aspect, from about 5% to about 10%.
  • the moisture content can vary depending on the nature of the composition.
  • the composition can be a complete and nutritionally balanced pet food.
  • the pet food may be a "wet food", “dry food”, or food of intermediate moisture content.
  • Wet food describes pet food that is typically sold in cans or foil bags, and has a moisture content typically in the range of about 70% to about 90%.
  • “Dry food” describes pet food which is of a similar composition to wet food, but contains a limited moisture content, typically in the range of about 5% to about 15% or 20%, and therefore is presented, for example, as small biscuit-like kibbles.
  • the compositions have moisture content from about 5% to about 20%.
  • Dry food products include a variety of foods of various moisture contents, such that they are relatively shelf-stable and resistant to microbial or fungal deterioration or contamination. Also included are dry food compositions which are extruded food products, such as pet foods, or snack foods for companion animals.
  • compositions may also comprise one or more fiber sources.
  • fiber includes all sources of “bulk” in the food whether digestible or indigestible, soluble or insoluble, fermentable or nonfermentable. Fibers can be from plant sources such as marine plants but microbial sources of fiber may also be used. A variety of soluble or insoluble fibers may be utilized, as will be known to those of ordinary skill in the art.
  • the fiber source can be beet pulp (from sugar beet), gum arabic, gum talha, psyllium, rice bran, carob bean gum, citrus pulp, fructooligosaccharide, pectin, short chain oligofructose, mannanoligofructose, soy fiber, arabinogalactan, galactooligosaccharide, arabinoxylan, or mixtures thereof.
  • the fiber source can be a fermentable fiber.
  • Fermentable fiber has previously been described to provide a benefit to the immune system of a companion animal.
  • Fermentable fiber or other compositions known to skilled artisans that provide a prebiotic to enhance the growth of probiotics within the intestine may also be incorporated into the composition to aid in the enhancement of the benefit provided by the present invention to the immune system of an animal.
  • compositions and dietaiy supplements may be specially formulated for the intended recipients or consumers, such as for adult animals or for older or young animals.
  • a composition adapted for puppies or kittens or adapted for active, pregnant, lactating, or aging animals can be prepared.
  • specialized compositions will comprise energy and nutritional requirements appropriate for animals at different stages of development or age.
  • compositions comprising the non-replicating Lactobacillus paracasei n probiotics, prebiotics, minerals, vitamins, and/or antioxidants, can be used with a high-quality commercial food.
  • high-quality commercial food refers to a diet manufactured to produce the digestibility of the key nutrients of 80% or more, as set forth in, for example, the recommendations of the National Research Council above for dogs, or in the guidelines set forth by the Association of American Feed Control Officials. Similar high nutrient standards would be used for other animals.
  • the food compositions comprise any of a variety of ingredients or combinations thereof selected for their contributions to the overall composition.
  • a skilled food technologist may choose from among natural (e.g., plant or plant-derived, animal or animal-derived, and microbial or microbially-derived), and synthetic ingredients or components.
  • the ingredients may include any of the cereal grains and/or fractions or components thereof, meat and meat by-products, fish, shellfish, or other seafood, other animal products or by-products, eggs from any source, vitamins, minerals, salts, sweeteners, fiber, flavoring or other palatants, coloring, and functional ingredients such as emulsifiers, stabilizers, softeners, functional coatings, and the like.
  • the source of fat is a plant fat such as corn, soy, or canola oil, including those that are readily available.
  • an animal fat, such as tallow is useful for providing calories from fat, as well as enticing flavor to meat-eating animals.
  • combinations of any of the foregoing ingredients, such as fats are known in the art and useful for optimizing the food compositions based on functional properties as well as price and availability.
  • the formulation may vary slightly, so as to allow consideration by the formulator of the price and/or availability of certain ingredients in the compositions, as well as the batch-to-batch variation in the analysis of certain ingredients.
  • the formulation may vary slightly, so as to allow consideration by the formulator of the price and/or availability of certain ingredients in the compositions, as well as the batch-to-batch variation in the analysis of certain ingredients.
  • composition or formulation may vary slightly from batch to batch, plant to plant, or even season to season depending on such factors. Notwithstanding such variation in specific ingredients selected for manufacturing a particular batch of a food composition, the overall composition (for example, analysis of protein, carbohydrate, fat, fiber, or other component) may be held constant or at least substantially constant, for example, in accordance with a label claim, such as a claim or guarantee of a minimum or maximum percent of a particular component.
  • a label claim such as a claim or guarantee of a minimum or maximum percent of a particular component.
  • the food compositions comprise a macronutrient
  • the food composition suitable for the type of food being designed.
  • the food composition can have about 20 to 32% protein, about 30 to 50% carbohydrate, about 5% to 20% fat, and about 15% to 25% moisture.
  • the food composition can be a pet food composition such as a premium or super-premium pet food composition.
  • the pet food can be formulated for canines and has a protein content of about 20- 30%, in one aspect, about 24-28%, and in one specific aspect, about 25-27%. In one
  • the protein content of a dog food composition can be about 26% by weight.
  • the formulation can be for felines and can have a protein content of about 35-45%, in one aspect, about 37-42%, and in one specific aspect, about 39-41%.
  • the protein content of a cat food composition can be about 40%.
  • the composition can be a food product comprising non-replicating Lactobacillus paracasei n vitamins, and antioxidants, and further comprising about 15% to about 50% protein, about 5% to about 40% fat, about 5% to about 10% ash content, and having a moisture content of about 5% to about 20%.
  • the food composition can be a wet food, such as a canned food, frozen food, or fresh food product.
  • the food composition can be shelf stable. In another, it can be refrigerated. In other embodiments, the food composition can be an intermediate moisture product or a dry food product as described above.
  • the invention provides pharmaceutical compositions comprising a composition of the present invention and one or more pharmaceutically-acceptable carriers, diluents, or excipients.
  • pharmaceutical compositions are prepared by admixing a compound or composition with excipients, buffers, binders, plasticizers, colorants, diluents, compressing agents, lubricants, flavorants, moistening agents, and the like, including other ingredients known to skilled artisans to be useful for producing pharmaceuticals and formulating compositions that are suitable for administration to an animal as pharmaceuticals.
  • Administration in accordance with the methods can be on an as-needed or as- desired basis of varying or regular frequency.
  • a goal of regular ingestion is to provide the animal with a regular and consistent dose of the composition.
  • Such regular and consistent dosing will tend to provide for improved oral health care.
  • administration on a regular basis can be once monthly, once weekly, once daily, or more than once daily.
  • administration can be ever ⁇ ' other day, week, or month, every third day, week, or month, every fourth day, week, or month, and the like.
  • Administration can be multiple times per day.
  • the composition may be administered directly to the animal, e.g., orally, or otherwise.
  • compositions can alternatively be contacted with, or admixed with, daily feed or food, including a fluid, such as drinking water, or an intravenous connection for an animal that is receiving such treatment.
  • a fluid such as drinking water
  • an intravenous connection for an animal that is receiving such treatment.
  • Administration can also be carried out as part of a dietary regimen for the animal.
  • a dietary regimen may comprise causing the regular ingestion by the animal of a composition described herein in an amount effective to promote or improve the oral health care in the animal.
  • administration of the compositions can span a period of time ranging from parturition through the adult life of the animal.
  • the companion animal can be a dog or cat.
  • the animal can be a young or growing animal.
  • the animal can be an aging animal. An animal that has reached about 35% of its projected lifespan can be included.
  • administration begins, for example, on a regular or extended regular basis, when the animal has reached more than about 30%, 40%, or 50% of its projected or anticipated lifespan.
  • the animal can have attained 40, 45, or 50% of its anticipated lifespan.
  • the animal can be older having reached 60, 66, 70, 75, or 80% of its likely lifespan.
  • determination of lifespan may be based on actuarial tables, calculations, estimates, or the like, and may consider past, present, and future influences or factors that are known to positively or negatively affect lifespan. Consideration of species, gender, size, genetic factors, environmental factors and stressors, present and past health status, past and present nutritional status, stressors, and the like may also influence or be taken into consideration when determining lifespan.
  • kits suitable for administering a composition comprising non-replicating Lactobacillus paracasei to a companion animal comprise in separate containers in a single package or in separate containers in a virtual package, as appropriate for the kit component, (a) non-replicating Lactobacillus paracasei, (b) a mineral, (c) a vitamin, and/or (d) an antioxidant; and (1) other ingredients suitable for consumption by an animal, (2) a prebiotic, (3) a probiotic, (4) instructions for how to combine or prepare the non-replicating Lactobacillus paracasei and any other ingredients provided in the kit for administration to an animal; (5) instructions for how to use the combined kit components, prepared kit components, or other kit components for the benefit of an animal; and/or (6) a device for administering the combined or prepared kit components to an animal.
  • kits may comprise the ingredients in various combinations.
  • the kit could comprise a mixture of non-replicating Lactobacillus paracasei, vitamins and antioxidants in one container and one or more other ingredients in one or more other containers.
  • Other such combinations can be produced by the skilled artisan based upon the characteristics of the ingredients and their physical and chemical properties and compatibilities.
  • the invention provides a means for communicating information about or instructions for one or more of (1) using compositions of the present invention for promoting or improving oral health care; (2) admixing the non-replicating Lactobacillus paracasei, vitamins, antioxidants, minerals, or other components of the invention to produce a composition suitable for promoting or improving oral health care; (3) using the kits of the present invention for promoting or improving oral health care; and (4) administering the compositions to an animal.
  • the means comprises one or more of a physical or electronic document, digital storage media, optical storage media, audio presentation, audiovisual display, or visual display containing the information or instructions.
  • the means can be selected from the group consisting of a displayed website, a visual display kiosk, a brochure, a product label, a package insert, an advertisement, a handout, a public announcement, an audiotape, a videotape, a DVD, a CD-ROM, a computer readable chip, a computer readable card, a computer readable disk, a USB device, a Fire Wire device, a computer memory, and any combination thereof.
  • the invention provides methods for manufacturing a food composition comprising non-replicating Lactobacillus paracasei, and one or more other ingredients suitable for consumption by an animal, e.g., protein, fat, carbohydrate, fiber, etc.
  • the methods comprise admixing one or more ingredients suitable for consumption by an animal with non-replicating Lactobacillus paracasei, and possibly other ingredients such as vitamins and/or antioxidants.
  • the methods comprise applying non-replicating Lactobacillus paracasei, and other ingredients if desired, separately or in any combination onto the food composition, e.g., as a coating or topping.
  • the non-replicating Lactobacillus paracasei can be added at any time during the manufacture and/or processing of the food composition. This includes, for example, admixing the non-replicating Lactobacillus paracasei as part of the core formulation of the "body" of the food composition or applying them as a coating, i.e., primarily to the surface of the food composition after its manufacture.
  • the compositions can be made according to any method suitable in the art.
  • the present invention provides a package comprising a composition of the present invention and a label affixed to the package containing a word or words, picture, design, acronym, slogan, phrase, or other device, or combination thereof, that indicates that the contents of the package contains a composition suitable for promoting and/or improving oral health care in an animal.
  • a composition suitable for promoting and/or improving oral health care in an animal Typically, such device comprises the words "improves oral health", or an equivalent expression printed on the package.
  • Any package or packaging material suitable for containing the composition can be useful in the invention, e.g., a bag, box, bottle, can, pouch, and the like manufactured from paper, plastic, foil, metal, and the like.
  • the package can contain a food composition adapted for a particular animal such as a canine or feline, as appropriate for the label, in one aspect, a companion animal food composition.
  • the animal can be a juvenile, adult, senior, or geriatric animal.
  • the animal can be an aging animal.
  • animals can be senior in the last half of their expected lifespan and geriatric in the last fourth of their expected lifespan. Lifespan definitions vary for various animals and are known to skilled artisans.
  • the animal can be considered to be juvenile until 1 year of age.
  • Re gion 123 Bacteria associated with non-replicating Lactobacillus paracasei supplementation
  • Region 456 Bacteria associated with non-replicating Lactobacillus paracasei supplementation
  • Bacteroidetes Bacteroidia Bacteroidales BS1 1 — ⁇
  • Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae ⁇ —
  • Bacteroidetes Bacteroidia Bacteroidales Po hyromo adaceae Tannerella forsythia
  • Bacteroidetes Bacteroidia Bacteroidales Po hyromonadaceae Po hyromonas ⁇
  • Lactobacillus paracasei compared to Baseline, and dogs on the control treatment had an
  • Porphyrin concentration for dogs receiving the non-replicating Lactobacillus paracasei treatment was 10% of the porphyrin concentration in

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Abstract

L'invention concerne des procédés pour favoriser et/ou améliorer la santé buccale chez un animal de compagnie. Dans un mode de réalisation, un procédé pour améliorer la santé buccale chez un animal de compagnie peut consister à identifier un animal de compagnie qui souffre d'un trouble de santé buccale, et à administrer une composition comprenant Lactobacillus paracasei sans réplication à l'animal de compagnie. En général, la composition est administrée dans une quantité efficace pour traiter le trouble de santé buccale chez l'animal.
PCT/IB2016/057898 2015-12-22 2016-12-21 Santé buccale pour animaux de compagnie WO2017109735A1 (fr)

Applications Claiming Priority (2)

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US201562270903P 2015-12-22 2015-12-22
US62/270,903 2015-12-22

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WO2017109735A1 true WO2017109735A1 (fr) 2017-06-29

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050180961A1 (en) * 2002-05-24 2005-08-18 Sophie Pecquet Probiotics and oral tolerance
WO2006027265A1 (fr) * 2004-09-10 2006-03-16 Basf Aktiengesellschaft Moyens et methodes de prevention et/ou de traitement des caries
WO2012100991A1 (fr) * 2011-01-24 2012-08-02 Basf Se Compositions améliorant la santé buccale
US20120230923A1 (en) * 2009-11-10 2012-09-13 Basf Se Health-Beneficial Preparation and Production Method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050180961A1 (en) * 2002-05-24 2005-08-18 Sophie Pecquet Probiotics and oral tolerance
WO2006027265A1 (fr) * 2004-09-10 2006-03-16 Basf Aktiengesellschaft Moyens et methodes de prevention et/ou de traitement des caries
US20120230923A1 (en) * 2009-11-10 2012-09-13 Basf Se Health-Beneficial Preparation and Production Method
WO2012100991A1 (fr) * 2011-01-24 2012-08-02 Basf Se Compositions améliorant la santé buccale

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